6,429 results match your criteria Acta tropica[Journal]


Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.

Acta Trop 2020 Jul 4:105619. Epub 2020 Jul 4.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

Chikungunya virus (CHIKV) is a zoonotic arthropod-borne virus that has caused several outbreaks in tropical and subtropical areas worldwide during the last 50 years. The virus is known to target different human cell types throughout the course of infection including epithelial and endothelial cells, fibroblasts, primary monocytes and monocyte-derived macrophages (MDMs). The two latter are phagocytic cell populations of the innate immune system which are involved in some aspects of CHIKV pathogenesis. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105619DOI Listing

Anti-amoebic potential of azole scaffolds and nanoparticles against pathogenic Acanthamoeba.

Acta Trop 2020 Jul 3:105618. Epub 2020 Jul 3.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.

Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105618DOI Listing

Lesions in osteoderms of pampatheres (Mammalia, Xenarthra, Cingulata) possibly caused by fleas.

Acta Trop 2020 Jul 2;211:105614. Epub 2020 Jul 2.

Programa de Pós-Graduação em Ecologia e Recursos Naturais, Laboratório de Paleoecologia e Paleoicnologia, Departamento de Ecologia e Biologia Evolutiva, Universidade Federal de São Carlos, Rod. Washington Luís, km 235, São Carlos, SP, Brasil.

In this study, the first records of lesions in osteoderms of Holmesina, a group of fossil cingulates related to armadillos, possibly caused by the action of penetrating fleas (Siphonaptera) are described. Three individuals of Holmesina cryptae (Pampatheriidae) were collected from Quaternary sediments in Lapinha Cave (Iramaia, Bahia state, Brazil). Their osteoderms were analyzed by stereomicroscope and scanning electron microscopy and alterations on their surfaces were recognized. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105614DOI Listing

Antiviral effect of silymarin against Zika virus in vitro.

Acta Trop 2020 Jul 1;211:105613. Epub 2020 Jul 1.

Programa de Pós-Graduação em Ciências Biológicas, Núcleo de Pesquisas em Ciências Biológicas, NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil. Electronic address:

Zika virus (ZIKV) epidemic and its association with severe neurological syndromes have raised worldwide concern. Despite the great clinical relevance of this infection, no vaccine or specific treatment is available and the search for antiviral compounds against ZIKV is extremely necessary. Several natural compounds, such as silymarin, exhibit antioxidant, hepatoprotective, and antiviral properties; however, the antiviral potential of this compound remains partially investigated. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105613DOI Listing

Description of two new species of Ectinorus (Ectinorus) (Siphonaptera, Rhopalopsyllidae) from Argentina, including a morphometric approach.

Acta Trop 2020 Jul 1:105612. Epub 2020 Jul 1.

Programa de Investigaciones de Biodiversidad Argentina (PIDBA) and Programa de Conservación de los Murciélagos de Argentina (PCMA), Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán, Miguel Lillo 205, San Miguel de Tucumán, CP 4000, Argentina.; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Tucumán, Argentina.

Two new species of fleas of genus Ectinorus (Siphonaptera: Rhopalopsyllidae) are described from sigmodontine rodents (Rodentia: Cricetidae) collected during a survey of small mammals in northwestern Argentina. The new species belong to the subgenus Ectinorus and can be distinguished from all other species of the subgenus by the characteristics of the modified abdominal segments and by the genitalia. Moreover, the male of Ectinorus (Ectinorus) disjugis is described for the first time and the finding of this flea parasitizing the rodent Akodon spegazzinii, constitutes a new flea-host association. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105612DOI Listing

Seasonal population dynamics and a role as natural vector of Leucocytozoon of black fly, Simulium chumpornense Takaoka & Kuvangkadilok.

Acta Trop 2020 Jul 2;211:105617. Epub 2020 Jul 2.

Secondary Educational Service Area Office 26, Maha Sarakham 44000, Thailand.

The black fly, Simulium chumpornense Takaoka & Kuvangkadilok, is suspected to be a natural vector of Leucocytozoon. In this study, seasonal variation in abundance of the adult fly and molecular detection of Leucocytozoon in S. chumpornense and in domestic chicken was investigated in northeastern Thailand. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105617DOI Listing

Growing diversity supports radiation of an Ellipsomyxa lineage into the Amazon freshwater: Description of two novel species parasitizing fish from Tapajós and Amazon rivers.

Acta Trop 2020 Jul 1;211:105616. Epub 2020 Jul 1.

Department of Ecology and Evolutionary Biology, Federal University of São Paulo - UNIFESP, Diadema, SP, Brazil; Department of Animal Biology, Institute of Biology, State University of Campinas - UNICAMP, Campinas, SP, Brazil.

Species of the genus Ellipsomyxa Køie, 2003, parasitize mostly marine and brackish fish around the world. In the present study, we describe two novel species of Ellipsomyxa: Ellipsomyxa plagioscioni n. sp. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105616DOI Listing

Spatiotemporal patterns and integrated approach to prioritize areas for surveillance and control of visceral leishmaniasis in a large metropolitan area in Brazil.

Acta Trop 2020 Jul 2;211:105615. Epub 2020 Jul 2.

Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Presidente Antônio Carlos 6627, 31270-901, Belo Horizonte, Minas Gerais, Brazil; London School of Hygiene and Tropical Medicine, University of London, Keppel St, Bloomsbury, WC1E 7HT, London, United Kingdom. Electronic address:

Visceral leishmaniasis (VL) is a neglected disease with worldwide distribution. Brazil is the country with the largest number of cases in the Americas, and the state of Minas Gerais presents a high VL-related burden and a high case fatality rate. We aimed to analyse the spatial and spatiotemporal patterns of VL occurrence and to identify priority risk areas for surveillance and control in the metropolitan region of Belo Horizonte-MG, the third largest metropolitan area in Brazil. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105615DOI Listing

The congenital toxoplasmosis burden in Brazil: Systematic review and meta-analysis.

Acta Trop 2020 Jun 29;211:105608. Epub 2020 Jun 29.

Pathology Laboratory, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil.

Congenital toxoplasmosis is a zoonosis caused by the intracellular Apicomplexa protozoan Toxoplasma gondii. This infection causes subclinical or clinical lesions, such as retinochoroiditis and central nervous system lesions. The severity of fetal infection is related to the stage of pregnancy and the efficacy of the gestational treatment on fetal infection, whether it is achieved, or if it starts early. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105608DOI Listing

A preliminary evaluation of a locally produced biotinylated polyclonal anti-rabies antibody for direct rapid immunohistochemical test (DRIT) in the Philippines.

Acta Trop 2020 Jun 28;211:105610. Epub 2020 Jun 28.

Department of Veterinary Science, National Institute for Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan.

Rabies is a fatal zoonotic disease endemic in developing countries of Asia and Africa. Recently, the direct rapid immunohistochemical test (DRIT) was recommended by the World Health Organization (WHO) and the World Organization for Animal Health (OIE) as a diagnostic test for rabies. Therefore, a biotinylated polyclonal antibody (pAb) against the rabies lyssavirus (RABV) nucleoprotein was developed using a plasmid cDNA vaccine derived from a challenge virus standard 11 strain. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105610DOI Listing

Niche divergence and paleo-distributions of Lutzomyia longipalpis mitochondrial haplogroups (Diptera: Psychodidae).

Acta Trop 2020 Jun 27;211:105607. Epub 2020 Jun 27.

Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública (INSP), Tapachula, Chiapas, México.

Lutzomyia longipalpis is a complex of species which has a wide but discontinuous distribution from southeastern Mexico to northern Argentina and Uruguay. To date, eight mitochondrial haplogroups have been identified along its distribution although key environmental tolerances and ecological niche models have been analyzed only at the complex level. The aim of the present study was to analyze whether genetic diversification using three mitochondrial genes of the Lu. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105607DOI Listing

In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models.

Acta Trop 2020 Jun 27;211:105606. Epub 2020 Jun 27.

Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños "Dr. Ricardo Gutiérrez". Ministerio de Salud. GCBA, Buenos Aires, Argentina; Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP), CONICET-GCBA, Buenos Aires, Argentina; Division of Pediatric Clinical Pharmacology, Department of Pediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, Canada. Electronic address:

Combination therapy has been proposed as an ideal strategy to reduce drug toxicity and improve treatment efficacy in Chagas disease. Previously, we demonstrated potent in vivo anti-Trypanosoma cruzi activity of voriconazole. In this work, we aimed to study the synergistic effect of voriconazole (VCZ) and benznidazole (BZ) both in vitro and in vivo models of T. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105606DOI Listing

One year of African swine fever outbreak in China.

Acta Trop 2020 Jun 26;211:105602. Epub 2020 Jun 26.

Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, PR China. Electronic address:

African swine fever (ASF) is a major threat to domestic pigs and wild boars. Since 2018, ASF outbreaks have been ongoing in China. As of August 3, 2019, a total of 151 ASF clusters of outbreaks reported in China have caused severe economic losses for the industry, the pig farmers and pork producers, due to the lack of an efficacious vaccine. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105602DOI Listing
June 2020
2.270 Impact Factor

VectorInfo: A web resource for medically important Indian arthropod disease vectors.

Acta Trop 2020 Jun 26;211:105601. Epub 2020 Jun 26.

Biomedical Informatics Centre, Vector Control Research Center, Indian Council of Medical Research, Pondicherry, 605006, India; Department of Biostatistics and Data Science, University of Kansas Medical Center, Kansas City, KS, 66160, USA. Electronic address:

VectorInfo is a freely accessible web resource, emphasised on medically important Indian arthropods funded by Indian Council of Medical Research (ICMR) and maintained by one of its premier institute, Vector Control Research Centre (VCRC). VectorInfo elucidates and curates medically important Indian arthropod's biological, omics technologies to adopt a holistic view of the molecules that make up an organism, aimed at the detection of genomics, transcriptomics, proteomics, enzymes & pathways and immune specific genes. The nitty-gritty of VectorInfo is aimed at scrutinizing all the possible information on Indian disease vectors in a single window for the scientific community. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105601DOI Listing

Effect of nitazoxanide on diarrhea: A systematic review and network meta-analysis of randomized controlled trials.

Acta Trop 2020 Jun 26:105603. Epub 2020 Jun 26.

Evidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, 70000, Vietnam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, 70000, Vietnam. Electronic address:

We aimed to systematically review evidence pertaining to the safety and efficacy of nitazoxanide in treating infectious diarrhea. On September 21, 2017, we identified relevant studies using 12 databases. The estimates of the included studies were pooled as a risk ratio (RR). Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105603DOI Listing

Detection of circulating cell-free DNA to diagnose Schistosoma japonicum infection.

Acta Trop 2020 Jun 26;211:105604. Epub 2020 Jun 26.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affairs, 518 Ziyue Road, Shanghai 200241, China.

Schistosomiasis occurs in 240 million people worldwide and is a major public health concern. Thus, early diagnosis and monitoring of schistosomiasis progression are needed to treat patients. Cell-free DNA (cfDNA) is present as fragments of parasite-derived DNA in host body fluids. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105604DOI Listing

Sand fly typing: a simple and morphologically-supported method based on polymorphism of 18S rRNA gene in a Leishmaniasis endemic area of Argentina.

Acta Trop 2020 Jun 27;211:105609. Epub 2020 Jun 27.

Instituto de Investigaciones de Enfermedades Tropicales, Universidad Nacional de Salta, Orán, Argentina; Instituto de Patología Experimental-CONICET, Facultad de Ciencias de la Salud, Universidad Nacional de Salta, Salta, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

Leishmaniases are vector-borne diseases that in the Americas are distributed from southern United States to northern Argentina. The vectors for this disease are small dipterans known as sand flies that are usually identified morphologically by observing structures with taxonomic value; but it is time-consuming, laborious, and requires entomological expertise. Then, this work was aimed at identifying sand flies with molecular techniques, using the morphological identification as a reference technique, in an endemic area of American Tegumentary Leishmaniasis (ATL) located in northern Argentina. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105609DOI Listing

Genetic polymorphism in IL17RA induces susceptibility to Toxoplasma gondii infection in Brazilian pregnant women.

Acta Trop 2020 Jun 26;211:105594. Epub 2020 Jun 26.

Laboratory of Malaria and Toxoplasmosis Biology/LABMAT, Department of Microbiology and Parasitology, Bioscience Center, Federal University of the Rio Grande do Norte. Natal, Rio Grande do Norte, Brazil.

Congenital toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, an obligate intracellular parasite which can cause fetal death/abortion and can induce damage in the brain and eyes of the infected babies. The environmental and genetic factors associated with T. gondii and the maternal immune response, drive part of the pathogenesis of congenital toxoplasmosis. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105594DOI Listing

Molecular detection and characterization of tick-borne haemoparasites among cattle on Zanzibar Island, Tanzania.

Acta Trop 2020 Jun 24;211:105598. Epub 2020 Jun 24.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. Electronic address:

Tick-borne diseases (TBDs) are serious constraints to livestock production in Tanzania and other tropical and subtropical countries and impact the livelihoods of resource-poor farming communities in the region. In Tanzania, detailed studies on tick-borne pathogens (TBPs) in cattle using sensitive molecular detection methods are scarce. The objective of this study was to investigate the occurrence and species composition of bovine TBPs in cattle kept in Zanzibar Island. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105598DOI Listing

Chagas bugs and trypanosoma cruzi: Puppets and puppeteer?

Acta Trop 2020 Jun 24;211:105600. Epub 2020 Jun 24.

Departamento de Ecología Evolutiva, Instituto de Ecología, Universidad Nacional Autónoma de México, Apdo. P. 70-275, Circuito Exterior, Ciudad Universitaria, 04510, Coyoacán, Distrito Federal, México. Electronic address:

A widely accepted idea in parasite-host relationships is that the former manipulates the latter so that it increases its own success. In the case of complex life cycles, this means that the parasite is able to manipulate the first host which allows its transmission to the second host. In this paper, I formalize the idea that this may be the case for the Trypanosoma cruzi parasite and its vectors, bugs of the subfamily Triatominae. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105600DOI Listing

Risk-free point-of-care visceral leishmaniasis diagnostics: combining buffy coat microscopy and immunoassay in tertiary rural hospitals in Sudan.

Acta Trop 2020 Jun 25;211:105599. Epub 2020 Jun 25.

Department of Parasitology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Egypt; Department of Microbiology-Medical Parasitology section, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, KSA. Electronic address:

Visceral Leishmaniasis (VL), a life-threating disease in Sudan and Eastern Africa, is usually diagnosed by a painful and invasive tissue aspirate microscopy. This study assessed the diagnostic effectiveness of buffy coat (BC) microscopy and the rK39 immunoassay test separately and combined as an easy non-invasive method applied to peripheral blood sample for field diagnosis of VL. 151 VL suspected patients were recruited from tertiary rural hospitals in Bazura, Gedaref state, from 2014-2015. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105599DOI Listing

Blending studies with selected waterbuck odor constituents or analogues in the development of a potent repellent blend against savannah tsetse.

Acta Trop 2020 Jun 25;211:105597. Epub 2020 Jun 25.

Department of Chemistry, School of Pure and Applied Sciences, Kenyatta University, P.O. Box 43844-00100, Nairobi, Kenya.

Previous comparison of the body odors of tsetse-refractory waterbuck and those of tsetse-attractive ox and buffalo showed that a blend of 15 EAG-active compounds specific to waterbuck, including C5-C10 straight chain carboxylic acid homologues, methyl ketones (C8-C12 straight chain homologues and geranyl acetone), phenols (guaiacol and carvacrol) and δ-octalactone, was repellent to tsetse. A blend of four components selected from each class of compounds (δ-octalactone, pentanoic acid, guaiacol, and geranylacetone) showed repellence that is comparable to that of the 15 components blend and can provide substantial protection to cattle (more than 80%) from tsetse bites and trypanosome infections. Structure-activity studies with the lactone and phenol analogues showed that δ-nonalactone and 4-methylguaiacol are significantly more repellent than δ-octalactone and guaiacol, respectively. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105597DOI Listing
June 2020
2.270 Impact Factor

Natural Plasmodium infection in wild macaques of three states in peninsular Malaysia.

Acta Trop 2020 Jun 23;211:105596. Epub 2020 Jun 23.

Department of Parasitology Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address:

Zoonotic cases of Plasmodium knowlesi account for most malaria cases in Malaysia, and humans infected with P. cynomolgi, another parasite of macaques have recently been reported in Sarawak. To date the epidemiology of malaria in its natural Macaca reservoir hosts remains little investigated. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105596DOI Listing

Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake.

Acta Trop 2020 Jun 23;211:105595. Epub 2020 Jun 23.

Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada, Universidade de Pernambuco (UPE), Rua Arnóbio Marques, 310, 50100-130, Recife/PE, Brazil; Instituto Aggeu Magalhães, Fundação Oswaldo Cruz (FIOCRUZ), Av. Prof. Moraes Rego, s/n, Cidade Universitária, 50670-420, Recife/PE, Brazil. Electronic address:

17-N-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) is an inhibitor of heat shock protein 90 (Hsp90), which has been studied in the treatment of cancer such as leukemia or solid tumors. Alternatively, 17-AAG may represent a promising therapeutic agent against leishmaniasis. However, the delivery of 17-AAG is difficult due to its poor aqueous solubility. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105595DOI Listing

Wing geometric morphometrics for identification of mosquito species (Diptera: Culicidae) of neglected epidemiological importance.

Acta Trop 2020 Jun 19:105593. Epub 2020 Jun 19.

Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.. Electronic address:

Culicidae comprises more than 3,500 species, some of which are responsible for the spread of various human diseases, causing millions of deaths worldwide. Correct identification of these species is essential for the development of surveillance and control strategies. The most common method of mosquito identification is based on specific traits of the external morphology of species. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105593DOI Listing

Binding of elastase-1 and enterocytes facilitates Trichinella spiralis larval intrusion of the host's intestinal epithelium.

Acta Trop 2020 Jun 18;211:105592. Epub 2020 Jun 18.

Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, PR China. Electronic address:

Elastase-1 is one member of serine protease family, distributes in organisms widely and plays a crucial role in the invasion and development of Trichinella spiralis. In order to identify the binding of T. spiralis elastase-1 (TsEla) with host's intestinal epithelial cells (IECs) and its role in Trichinella larval intrusion, TsEla gene was cloned and expressed in our previous study. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105592DOI Listing

Effect of recombinant serine protease from newborn larval stage of Trichinella spiralis on 2,4,6-trinitrobenzene sulfonic acid-induced experimental colitis in mice.

Acta Trop 2020 Jun 17;211:105553. Epub 2020 Jun 17.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China. Electronic address:

Inflammatory bowel disease (IBD) is a complex immune-mediated disease of gastrointestinal tract that is mainly driven by Th1/Th17 immune response. "Helminth therapy" has emerged, and helminth-derived immunoregulatory molecules are being used as safe and new therapeutic antigens for IBD. Recombinant serine protease (SP) from newborn Trichinella spiralis (T. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105553DOI Listing

Low genetic diversity and strong immunogenicity within the apical membrane antigen-1 of plasmodium ovale spp. imported from africa to china.

Acta Trop 2020 Jun 17;210:105591. Epub 2020 Jun 17.

Laboratory of Pathogen Infection and Immunity, Department of Public Health and Preventive Medicine; Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. Electronic address:

Malaria is still an important challenge for global public health because of its extensive mortality and morbidity. Plasmodium ovale is mainly distributed in tropical regions of Africa and Asia. it includes two distinct ovale malaria species, which are P. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105591DOI Listing

Human myiasis cases originating and reported in africa for the last two decades (1998-2018): A review.

Acta Trop 2020 Jun 16;210:105590. Epub 2020 Jun 16.

Department of Chemical and Physical Sciences, Walter Sisulu University, P/Bag X1, Mthatha 5117, South Africa. Electronic address:

The article reviews literature on myiasis in Africa and cases that originated in Africa over the last two decades (1998-2018). The relevant literature was obtained by using several databases (Science-Direct, JSTOR, Google Scholar, Ebscohost and PubMed). We searched for the following words or their combination myiasis, maggots, fly species responsible for myiasis found in Africa, and the different types of myiasis. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105590DOI Listing

Molecular detection of rickettsial bacteria in ticks of the genus Ixodes from the Southern Cone of America.

Acta Trop 2020 Jun 15;210:105588. Epub 2020 Jun 15.

Instituto Nacional de Tecnología Agropecuaria, Estación Experimental Agropecuaria Rafaela, and Consejo Nacional de Investigaciones Científicas y Técnicas, CC 22, CP 2300, Rafaela, Santa Fe, Argentina.

To obtain information about rickettsial bacteria in ticks of the genus Ixodes from Argentina and Uruguay, specimens of I. fuscipes (previously named as I. aragaoi), Ixodes pararicinus, Ixodes sp. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105588DOI Listing

Comparative transcriptome analysis of normal and CD44-deleted mouse brain under chronic infection with Toxoplasma gondii.

Acta Trop 2020 Jun 13;210:105589. Epub 2020 Jun 13.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, No.1, Shizishan Street, Wuhan, Hubei Province 430070, PR China. Electronic address:

Toxoplasma gondii is a globally-distributed intracellular parasitic protozoon with wide host range. Chronic infection is the most prevalent form of T. gondii infection, which can lead to significant damage. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105589DOI Listing
June 2020
2.270 Impact Factor

The immunotherapy with hMASP-2 DNA nanolipoplexes against echinococcosis in experimentally protoscolex-infected mice.

Acta Trop 2020 Jun 12;210:105579. Epub 2020 Jun 12.

Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; Key Lab of Preclinical Study for New Drugs of Gansu Province, Lanzhou, 730000, China. Electronic address:

Cystic echinococcosis (CE), a complex and neglected zoonotic infectious disease, is mainly caused by larval tapeworm Echinococcus granulosus with a worldwide distribution. For CE, an effective drug treatment is not yet available. The present study was conducted to evaluate the efficacy of hMASP-2-based immunotherapy against hydatid cysts by using murine model. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105579DOI Listing

Population structure of leishmania major in southeastern morocco.

Acta Trop 2020 Jun 11;210:105587. Epub 2020 Jun 11.

Laboratory of Parasitology and Vector-Borne-Diseases, Institut Pasteur du Maroc, Casablanca, Morocco. Electronic address:

Cutaneous leishmaniasis (CL) is an infectious disease caused by various Leishmania species. It is among the most neglected tropical diseases and has been considered a major health threat over the past decades in the country. Its zoonotic form caused by Leishmania (L) major is the most prevalent in Morocco. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105587DOI Listing

Cutaneous leishmaniasis in male schoolchildren in the upper and lower Dir districts of Khyber Pakhtunkhwa, and a review of previous record in Pakistan.

Acta Trop 2020 Jun 10;209:105578. Epub 2020 Jun 10.

Institute of Environmental and Occupational Health Sciences, Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.

Documented reports are limited, showing cutaneous leishmaniasis (CL) as a severe threat to schoolchildren in Pakistan. The present study aimed to investigate the clinico-epidemiology and associated risk factors of CL in local and Afghan male schoolchildren between 6 and 16 years of age. The experimental strategy involved a questionnaire for the collection of information and clinical diagnosis (microscopy and semi-nested PCR) of 113 CL symptomatic schoolchildren out of 8,833 schoolchildren (7,175 local and 1,658 Afghan refugees) studying in nineteen schools of the Upper and Lower Dir Districts, Khyber Pakhtunkhwa, Pakistan. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105578DOI Listing

Metabolic profiles of Oncomelania hupensis after molluscicidal treatment: Carbohydrate metabolism targeted and energy deficiency.

Acta Trop 2020 Jun 10;210:105580. Epub 2020 Jun 10.

Department of Parasitology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei Province, China. Electronic address:

Oncomelania hupensis is the intermediate host of Schistosoma japonicum, one of the Schistosoma species that can cause human schistosomiasis. Molluscicidal treatment remains the primary means to control snail. Niclosamide is the only molluscicide recommended by the World Health Organization, and it has been used throughout schistosomiasis-endemic areas in China for almost 30 years. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105580DOI Listing
June 2020
2.270 Impact Factor

Shelter dogs as indicators for Trypanosoma cruzi infection in an urban area of Aracaju, Brazil.

Acta Trop 2020 Jun 9;210:105577. Epub 2020 Jun 9.

Postgraduate Program in Health and Environment, Tiradentes University-UNIT, Av. Murilo Dantas, 300, Aracaju, Sergipe, 49032-490, Brazil; Institute of Technology and Research - ITP, Av. Murilo Dantas, 300, Aracaju, Sergipe, 49032-490, Brazil. Electronic address:

Shelters are places that receive certain species of domestic animals, mostly dogs and cats, that are normally abandoned. These animals are easy to handle because they are crowded and have limited movement. Dogs, due to the close relationship with humans, are considered the main domestic reservoirs in the peridomiciliary cycle of American trypanosomiasis infection in humans. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105577DOI Listing

Trypanosomes of vectors and domestic dogs in Trypanosoma cruzi transmission areas from Brazilian southwestern amazon: New mammalian host for Trypanosoma janseni.

Acta Trop 2020 Jun 8;210:105504. Epub 2020 Jun 8.

Laboratório de Biologia de Tripanosomatídeos, Intituto Oswaldo Cruz, Fiocruz, Av. Brasil, instead of biologia de tripanosomatídeos, instituto oswaldo cruz, fiocruz, Av. Brasil. Electronic address:

Trypanosoma cruzi is a widespread protozoan in Latin America causing Chagas disease in humans and able to infect several other mammal species. The objective of this study was to investigate the T. cruzi infection in triatomine fauna as well as in dogs from distinct areas of Acre, western Brazilian Amazonia, which recently reported acute cases of human CD as well as an area that have not notify this disease recently. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105504DOI Listing

Landscape effects on the abundance of Lutzomyia longipalpis and Migonemyia migonei (Diptera: Psychodidae: Phlebotominae) in Corrientes city, northern Argentina.

Acta Trop 2020 Jun 5;210:105576. Epub 2020 Jun 5.

Instituto de Investigaciones Biológicas y Tecnológicas (IIBYT), Universidad Nacional, de Córdoba, CONICET, Centro de Investigaciones Entomológicas de Córdoba (CIEC), FCEFyN. Córdoba, Córdoba, Argentina; CONICET-CCT Nordeste-Córdoba, Argentina. Electronic address:

We analyses the relationship between landscape and environmental variables estimated from high-resolution satellite images with the temporal variation of the abundance of Lutzomyia longipalpis and Migonemyia migonei, vectors of leishmaniasis, in Corrientes city. At 8 collection sites, 14 samples were conducted between March 2012 to February 2014. Proportion of land cover classes derived from high resolution satellite images as: water, bare soil, urban areas, low vegetation and high vegetation, as well as average, maximum and minimum values of Normalized Difference Vegetation Index and Normalized Difference Water Index) in buffer areas of 50 m, 100 m and 150 m were used to characterize and identify suitable environmental conditions for the development of sand flies through Generalized Linear Mixed Models. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105576DOI Listing

Fasciola hepatica-derived molecules as potential immunomodulators.

Acta Trop 2020 Jun 4;210:105548. Epub 2020 Jun 4.

Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala, s/n, 11340 Ciudad de México, México. Electronic address:

Through the years, helminths have co-existed with many species. This process has allowed parasites to live within them for long periods and, in some cases, to generate offspring. In particular, this ability has allowed Fasciola hepatica to survive the diverse immunological responses faced within its wide range of hosts. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105548DOI Listing
June 2020
2.270 Impact Factor

Salivary gland transcriptome of the Asiatic Triatoma rubrofasciata.

Acta Trop 2020 Jun 5;210:105473. Epub 2020 Jun 5.

Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan. Electronic address:

Salivary gland transcriptome analysis of the Asiatic Triatoma rubrofasciata was performed by high-throughput RNA sequencing. This analysis showed that the majority of reads accounting for 85.38% FPKM (fragments per kilobase of exon per million mapped fragments) were mapped with a secreted class. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105473DOI Listing

Design, development and assessment of an essential oil based slow release vaporizer against mosquitoes.

Acta Trop 2020 Jun 4;210:105573. Epub 2020 Jun 4.

Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur-784001, Assam, India. Electronic address:

Mosquitoes (Diptera; Culicidae) are a biting nuisance and are of economic and health importance, especially for people living in tropical countries like India. Given the environmental concerns and health hazards of synthetic insecticides, development of natural products for the control of mosquito and mosquito-borne diseases are needed. In view of this, an essential oil based novel liquid vaporizer formulation with citronella and eucalyptus oils has been developed using a computer aided Artificial Neural Network and Particle Swarm Optimization (ANN-PSO) algorithm approach, aiming to predict the best optimized formulation (OF). Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105573DOI Listing
June 2020
2.270 Impact Factor

Epidemiology and risk factors of Strongyloides stercoralis infection in Papua, Indonesia: a molecular diagnostic study.

Acta Trop 2020 Jun 4;209:105575. Epub 2020 Jun 4.

Postgraduate Programme in Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Center for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. Electronic address:

Strongyloides stercoralis is a parasitic worm that is of considerable clinical relevance. Indeed, it may persist asymptomatically for many years, but can lead to potentially fatal dissemination when the host's immune status is impaired. As commonly employed stool microscopy techniques (e. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105575DOI Listing

Prevalence and genetic diversity of avian haemosporidian parasites at an intersection point of bird migration routes: Sultan Marshes National Park, Turkey.

Acta Trop 2020 Jun 3;210:105465. Epub 2020 Jun 3.

Department of Parasitology, Faculty of Veterinary Medicine, Erciyes University, 38039, Kayseri, Turkey; Vectors and Vector-Borne Diseases Implementation and Research Center, Erciyes University, 38039, Kayseri, Turkey.

Avian haemosporidians (Haemosporida) represent a globally distributed, species-rich multiparasite-multihost host-parasite system. Each year, many of these parasite lineages are carried between temperate and tropical regions by migratory birds. While several factors can limit the transmission of avian haemosporidians to new areas, recent studies have shown that some abundant parasites can sometimes disperse and be transmitted in new areas to become emerging infectious diseases. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105465DOI Listing
June 2020
2.270 Impact Factor

Toxoplasma gondii infection in patients with lung diseases in Shandong province, eastern China.

Acta Trop 2020 Jun 3;211:105554. Epub 2020 Jun 3.

Department of Urinary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China. Electronic address:

Toxoplasma gondii, an intracellular protozoan parasite, can induce various clinical symptoms. T. gondii has been considered to play an important role in the pathogenesis of lung diseases. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105554DOI Listing

Leptospira interrogans in wild Boa constrictor snakes from Northeast Brazil peri‑urban rainforest fragments.

Acta Trop 2020 Jun 3;209:105572. Epub 2020 Jun 3.

Laboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia State, 40110-100, Brazil. Electronic address:

Leptospirosis, a disease that occurs worldwide, especially in tropical regions, is caused by bacteria of the genus Leptospira and affects mammals, amphibians, and reptiles. Boa constrictor snakes are commonly found in Atlantic rainforest fragments in peri‑urban areas, which indicates a greater possibility of the contact of these animals with humans residing there. Therefore, the aim of this work was to detect Leptospira spp infection through molecular assays in wild B. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105572DOI Listing

Foot and mouth disease in a wide range of wild hosts: a potential constraint in disease control efforts worldwide particularly in disease-endemic settings.

Acta Trop 2020 Jun 3;210:105567. Epub 2020 Jun 3.

University of Veterinary and Animal Sciences, Lahore 54600, Pakistan.

Foot and mouth disease (FMD) is a viral disease that affects predominantly cloven-footed animal species within the order Artiodactyla. The potential of the virus to transmit, maintain and circulate itself across a wide range of susceptible hosts, including both domestic and wild ungulates, remains a single major obstacle in an effective eradication of disease worldwide, particularly in disease-endemic settings. Hence, a better understanding of virus transmission dynamics is very much crucial for an efficient control of the disease, particularly at places or regions where wildlife and livestock rearing co-exists. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105567DOI Listing

Trypanosoma cruzi could affect wild triatomine approaching behaviour to humans by altering vector nutritional status: A field test.

Acta Trop 2020 Jun 3;210:105574. Epub 2020 Jun 3.

Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

Hematophagous insects exhibit complex behaviour when searching for blood-meals, responding to several host stimuli. The hematophagous insect Mepraia spinolai is a wild vector of Trypanosoma cruzi, causative agent of Chagas disease in humans, in the semiarid-Mediterranean ecosystem of Chile. In this study, we evaluated the association between the approaching behaviour to a human host, with T. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105574DOI Listing

Molecular Phylogeny and taxonomy of a new Myxobolus species from the endangered ornamental fish, Otocinclus cocama endemic to Peru: A host-parasite coextinction approach.

Acta Trop 2020 Jun 2;210:105545. Epub 2020 Jun 2.

Department of Zoology, Institute of Biosciences, University of São Paulo, 05508-090, São Paulo, Brazil.

A new Myxobolus species is described infecting gill filaments of the endangered ornamental fish Otocinclus cocama from Peruvian Amazon. In a total of 35 fish examined, five (14.3%) had myxozoan plasmodia. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105545DOI Listing

New records and DNA barcoding of deer flies, Chrysops (Diptera: Tabanidae) in Thailand.

Acta Trop 2020 Jun 1;210:105532. Epub 2020 Jun 1.

Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok, 10900, Thailand.

Chrysops spp. or deer flies (Diptera: Tabanidae) are hematophagous flies of medical and veterinary importance and some species are important vectors of Trypanosoma evansi, the causative agent of surra in Thailand. However, data regarding deer fly species and their molecular identification are limited. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105532DOI Listing
June 2020
2.270 Impact Factor

Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.

Acta Trop 2020 May 31;210:105560. Epub 2020 May 31.

Anhui Provincial Laboratory of Microbiology and Parasitology, Anhui Medical University, Hefei, China. Electronic address:

Toxoplasma gondii (T. gondii) is a neurophilic and intracellular parasite that can affect plenty of vertebrate animals, including humans. Recent researches indicate that T. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105560DOI Listing
May 2020
2.270 Impact Factor