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    5437 results match your criteria Acta tropica[Journal]

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    Development of an empirical model to predict malaria outbreaks based on monthly case reports and climate variables in Hefei, China, 1990-2011.
    Acta Trop 2017 Nov 11. Epub 2017 Nov 11.
    Department of Endemic Disease Control, Hefei Municipal Center Disease Control and Prevention, Hefei, 230061, People's Republic of China.
    Malaria remains a significant public health concern in developing countries. Drivers of malaria transmission vary across different geographical regions. Climatic variables are major risk factor in seasonal and secular patterns of P. Read More

    The epidemic typhus and trench fever are risk for public health due to increased migration in southeast of Turkey.
    Acta Trop 2017 Nov 7. Epub 2017 Nov 7.
    Cukurova University, Medical Faculty, Medical Parasitology, Adana, Turkey.
    Pediculus humanus capitis is a small ectoparasitic insect that has lived and feds on human beings for thousands of years. Molecular techniques have been used for Pediculus species identification and evolutionary, phylogenic, and ecological studies. A total of 23 adults of P. Read More

    The effect of reinfection and mixed Trypanosoma cruzi infections on disease progression in mice.
    Acta Trop 2017 Nov 4;178:107-114. Epub 2017 Nov 4.
    School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch 6150, Australia; Freshwater Fish Group and Fish Health Unit, Murdoch University,South Street, Murdoch 6150, Australia. Electronic address:
    The progression of Chagas disease (CD) varies significantly from host to host and is affected by multiple factors. In particular, mixed strain infections and reinfections have the potential to exacerbate disease progression subsequently affecting clinical management of patients with CD. Consequently, an associated reduction in therapeutic intervention and poor prognosis may occur due to this exacerbated disease state. Read More

    Genomics and molecular epidemiology of Cryptosporidium species.
    Acta Trop 2017 Oct 27. Epub 2017 Oct 27.
    Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
    Cryptosporidium is one of the most widespread protozoan parasites that infects domestic and wild animals and is considered the second major cause of diarrhea and death in children after rotavirus. So far, around 20 distinct species are known to cause severe to moderate infections in humans, of which Cryptosporidium hominis and Cryptosporidium parvum are the major causative agents. Currently, ssurRNA and gp60 are used as the optimal markers for differentiating species and subtypes respectively. Read More

    Seroprevalence of Schmallenberg virus in dairy cattle in Ethiopia.
    Acta Trop 2017 Oct 27;178:61-67. Epub 2017 Oct 27.
    School of Veterinary Medicine, Hawassa University, P.O. Box 05, Hawassa, Ethiopia. Electronic address:
    Schmallenberg virus (SBV) is a recently identified member of the genus Orthobunyavirus of the family Bunyaviridae. It is an arbovirus transmitted by different members of Culicoides spp of biting midges. The virus is more recognized for its effect on reproductive disorders in ruminants characterised by abortion, stillbirth and birth of congenitally defective newborns with hydranencephaly-arthrogryposis syndrome. Read More

    KIR-like activating natural killer cell receptors and their association with complicated malaria in north India.
    Acta Trop 2017 Oct 27;178:55-60. Epub 2017 Oct 27.
    Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India. Electronic address:
    Killer immunoglobulin-like receptors (KIRs) genomic regions have been suggested to influence malaria pathogenesis and infection susceptibility. KIRs are known as activating natural killer (NK) cell receptors, which upon binding to their corresponding human leukocyte antigen (HLA) ligands cause lysis of any infected cell. We have examined the potential association of KIR genes with complicated malaria (CM) among north Indians in this study and further evaluated the KIR receptor-HLA ligand association on the severity of the disease considering the uncomplicated malaria (UCM) subjects as control. Read More

    Biogenic silver nanoparticles inducing Leishmania amazonensis promastigote and amastigote death in vitro.
    Acta Trop 2017 Oct 27;178:46-54. Epub 2017 Oct 27.
    Laboratory of Experimental Protozoology, Department of Pathological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, Paraná, Brazil.
    American Cutaneous Leishmaniasis (ACL) is a zoonosis caused by Leishmania protozoa. The ACL chemotherapy available is unsatisfactory motivating researches to seek alternative treatments. In this study, we investigated the action of biogenic silver nanoparticle (AgNp-bio) obtained from Fusarium oxysporium, against Leishmania amazonensis promastigote and amastigote forms. Read More

    A rapid high-resolution melting method for differentiation of Leishmania species targeting lack gene.
    Acta Trop 2017 Oct 28;178:103-106. Epub 2017 Oct 28.
    Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:
    Objectives: The aim of this research is to verify that if lack gene can be used for differentiation of Leishmania under HRM assay.

    Methods: Two specific primers were designed targeting polymorphic sites on the lack gene sequence. DNA from promastigotes of six species of Leishmania based on reference strains were tested following a HRM protocol. Read More

    Triatoma infestans relies on salivary lysophosphatidylcholine to enhance Trypanosoma cruzi transmission.
    Acta Trop 2017 Oct 28;178:68-72. Epub 2017 Oct 28.
    Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, CEP 21940-590, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular - INCT - EM, Universidade Federal do Rio de Janeiro, CEP 21940-590, Rio de Janeiro, RJ, Brazil. Electronic address:
    Triatoma infestans is a mandatory haematophagous vector of Chagas disease in Brazil. Despite a large number of studies on the anti-haemostatic molecules present in its saliva, the role of its salivary components on parasite transmission is poorly understood. Here, we show that the bioactive lipid molecule, lysophosphatidylcholine (LPC), is present in the salivary gland of T. Read More

    A multiplex microfluidic loop-mediated isothermal amplification array for detection of malaria-related parasites and vectors.
    Acta Trop 2017 Nov 2;178:86-92. Epub 2017 Nov 2.
    Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA and State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address:
    Malaria infection poses a great threaten to public health even nowadays. The conventional diagnosis tools of malaria parasites and vectors require systematic training for the observers accompanied by the low throughput. In this study, a new detection system, i. Read More

    Seasonal distribution of Phlebotomine sandfly in a vulnerable area for tegumentary leishmaniasis transmission in Córdoba, Argentina.
    Acta Trop 2017 Nov 1;178:81-85. Epub 2017 Nov 1.
    Instituto de Investigaciones Biológicas y Tecnológicas (IIByT) CONICET-UNC, Centro de Investigaciones Entomológicas de Córdoba (CIEC), Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Avenida Vélez Sarsfield 1611, X5016GCA, Argentina.
    Thirty-seven sandfly species are listed for Argentina distributed in 14 provinces and Leishmaniasis cases extend from the north of the country to Unquillo City (Córdoba Province), but potential vectors are found further to the south. This is the first study on diversity, spatial and temporal distribution of sandflies on the outskirts of the temperate Córdoba City, and the factors that influence their presence. Migonemyia migonei, record here for Córdoba City for the first time, and the Evandromyia cortelezzii-sallesi Complex was found, also Ev. Read More

    Laboratory assessment of divaricatic acid against Biomphalaria glabrata and Schistosoma mansoni cercariae.
    Acta Trop 2017 Oct 31;178:97-102. Epub 2017 Oct 31.
    Laboratório de Produtos Naturais, Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, Brazil.
    In this study, the molluscicidal and antiparasitic activities of divaricatic acid was evaluated, targeting the mollusc Biomphalaria glabrata and cercariae of the helminth Schistosoma mansoni. In addition, the environmental toxicity of divaricatic acid was assessed by bioassay using the microcrustacean Artemia salina. Divaricatic acid showed high toxicity against both adult snails (5μg/mL) and embryos (20μg/mL after 6h of exposure). Read More

    Molecular detection of Toxoplasma gondii and Neospora caninum in birds from South Africa.
    Acta Trop 2017 Oct 29;178:93-96. Epub 2017 Oct 29.
    Department of Biodiversity, University of Limpopo, Sovenga 0727, South Africa.
    There are not any records on the detection of Toxoplasma gondii and Neospora caninum in tissues of wild birds in the African continent. The aim of the study was to investigate the occurrence of DNA from these protozoan parasites in brain tissue samples collected in years 2014-2015 from 110 wild and domestic birds of 15 orders. Birds came mainly from the province of Limpopo (n=103); the other seven birds came from other five provinces of South Africa. Read More

    Gold nanoparticles - against parasites and insect vectors.
    Acta Trop 2017 Oct 29;178:73-80. Epub 2017 Oct 29.
    Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy; The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy. Electronic address:
    Nanomaterials are currently considered for many biological, biomedical and environmental purposes, due to their outstanding physical and chemical properties. The synthesis of gold nanoparticles (Au NPs) is of high interest for research in parasitology and entomology, since these nanomaterials showed promising applications, ranging from detection techniques to drug development, against a rather wide range of parasites of public health relevance, as well as on insect vectors. Here, I reviewed current knowledge about the bioactivity of Au NPs on selected insect species of public health relevance, including major mosquito vectors, such as Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus. Read More

    Investigating the association between African spontaneously fermented dairy products, faecal carriage of Streptococcus infantarius subsp. infantarius and colorectal adenocarcinoma in Kenya.
    Acta Trop 2017 Oct 25;178:10-18. Epub 2017 Oct 25.
    Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland. Electronic address:
    Consumption of traditional fermented dairy products (tFDP) in Africa leads to the ingestion of up to 10(8)Streptococcus infantarius subspecies infantarius (Sii) per millilitre of spontaneously fermented milk. Sii is a member of the Streptococcus bovis/Streptococcus equinus complex (SBSEC) for which some members are associated particularly with colorectal cancer or endocarditis. The extent of health risks to tFDP consumers is largely unknown. Read More

    Potential exposure of humans to Rickettsia felis in Greece.
    Acta Trop 2017 Oct 24;178:40-45. Epub 2017 Oct 24.
    Laboratory of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, School of Medicine, University of Crete, Greece; Regional Laboratory of Public Health of Crete, School of Medicine, University of Crete, Greece. Electronic address:
    Rickettsia felis is a flea-transmitted pathogen however, in Greece, much work has been done on another flea-borne pathogen, R. typhi; human cases have been described and high-risk areas have been characterized. Nevertheless, little is known about human infections caused by R. Read More

    Scorpion envenoming in Morona Santiago, Amazonian Ecuador: Molecular phylogenetics confirms involvement of the Tityus obscurus group.
    Acta Trop 2017 Oct 25;178:1-9. Epub 2017 Oct 25.
    Carrera de Biotecnología, Facultad de Ingenierías y Ciencias Agropecuarias, Universidad de Las Américas, Quito, Ecuador; Laboratorio de Biología Molecular de Toxinas y Receptores, Instituto de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Caracas 1051, Venezuela. Electronic address:
    Scorpion envenoming by species in the genus Tityus is hereby reported from rural locations in the Amazonian province of Morona Santiago, southeastern Ecuador. Twenty envenoming cases (18 patients under 15 years of age) including one death (a 4-year-old male) were recorded at the Macas General Hospital, Morona Santiago, between January 2015 and December 2016 from the counties of Taisha (n=17), Huamboyo (n=1), Palora (n=1), and Logroño (n=1). An additional fatality from 2014 (a 3-year-old female from Nayantza, Taisha county) is also reported. Read More

    Production and evaluation of recombinant Burkholderia pseudomallei GroEL and OmpA proteins for serodiagnosis of melioidosis.
    Acta Trop 2017 Oct 23. Epub 2017 Oct 23.
    Faculty of Medical Technology, Rangsit University, MuangAke, Pathumthani, 12000, Thailand.
    Melioidosis is a bacterial infectious disease caused by Burkholderia pseudomallei (B. pseudomallei). The variable clinical manifestations of this disease make its diagnosis difficult. Read More

    Associations of DC-SIGN (CD209) promoter -336G/A polymorphism (rs4804803) with dengue infection: A systematic review and meta-analysis.
    Acta Trop 2018 Jan 18;177:186-193. Epub 2017 Oct 18.
    Division of Infectious Diseases, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
    Background And Aim: Dengue virus entry into a host is associated with a cell surface protein, DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin). A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF). However, the reported associations of these two outcomes and CD-209 have been inconsistent, which prompted a meta-analysis to obtain more precise estimates. Read More

    Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia.
    Acta Trop 2018 Jan 17;177:179-185. Epub 2017 Oct 17.
    Division of Infectious Diseases, Duke Global Health Institute, Duke University, Durham, NC, USA; Division of Infectious Diseases, School of Medicine, Duke University, Durham, NC, USA. Electronic address:
    Background: To better understand the epidemiology of tick-borne disease in Mongolia, a comprehensive seroprevalence study was conducted investigating exposure to Anaplasma spp. and spotted fever group (SFG) Rickettsia spp. in nomadic herders and their livestock across three provinces from 2014 to 2015. Read More

    Modeling and comparative study of the spread of zoonotic visceral leishmaniasis from Northern to Central Tunisia.
    Acta Trop 2017 Oct 16;178:19-26. Epub 2017 Oct 16.
    Institut Pasteur de Tunis, Tunis, Tunisia. Electronic address:
    During the last twenty years, zoonotic visceral leishmaniasis (ZVL) spread from the north characterized by humid, sub-humid, and semi-arid bio-climates to the arid areas located in Central Tunisia. In order to understand the eco-epidemiological factors involved in the distribution of ZVL, both a sero-epidemiological and an entomological investigation were performed in two governorates situated in two different bio-geographical areas: Bizerte in the north and Kairouan in the center. A mathematical model for transmission of ZVL was built, describing the disease dynamic in these areas. Read More

    High frequency of trypanosomatids in gallery forest bats of a Neotropical savanna.
    Acta Trop 2018 Jan 16;177:200-206. Epub 2017 Oct 16.
    Laboratório de Parasitologia Médica e Biologia de Vetores, Faculdade de Medicina, Universidade de Brasília, Brazil. Electronic address:
    Bats are well-known hosts of trypanosomatids, though information about their role as reservoirs of these protozoans in the Brazilian savanna is poorly known. We aimed to analyze the occurrence of trypanosomatid species in bats occurring in remnants of gallery forests of Brasília, Federal District of Brazil. We sampled bats using mist nets in six sites, and we collected blood, wing fragments and oral swab samples from all captured individuals. Read More

    Molecular epidemiology and in vitro evidence suggest that Leishmania braziliensis strain helps determine antimony response among American tegumenary leishmaniasis patients.
    Acta Trop 2017 Oct 16;178:34-39. Epub 2017 Oct 16.
    Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Brazil; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Brazil; Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Brazil. Electronic address:
    Antimony is the first line drug for treating American tegumentary leishmaniasis (ATL) in Brazil. In this country, Leishmania braziliensis causes at least three distinct forms of disease: localized cutaneous (CL), mucosal (ML) and disseminated leishmaniasis (DL). All forms can be found in Corte de Pedra, Northeast Brazil. Read More

    Biology of the introduced species Triatoma lecticularia (Hemiptera: Reduviidae) to northwestern Mexico, under laboratory conditions.
    Acta Trop 2018 Jan 16;177:194-199. Epub 2017 Oct 16.
    Laboratorio de Entomología Médica, Centro Universitario del Sur, Universidad de Guadalajara, Av. Enrique Arreola Silva 883, 49000, Ciudad Guzmán, Jalisco, Mexico. Electronic address:
    The first record of Triatoma lecticularia out of its reported distribution area together with the brief description of the said area is provided in this paper. In addition, some biological parameters related to hatching of eggs, life cycle and feeding and defecation behaviors for each instar of one population of T. lecticularia from its previously reported distribution area (PR) and for each instar of that introduced recently found population (IS) of this species were evaluated and compared. Read More

    Immunization with LJM11 salivary protein protects against infection with Leishmania braziliensis in the presence of Lutzomyia longipalpis saliva.
    Acta Trop 2018 Jan 14;177:164-170. Epub 2017 Oct 14.
    Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BA, Brazil; Instituto Nacional de Ciência e Tecnologia (INCT) de Investigação em Imunologia, Salvador, BA, Brazil. Electronic address:
    Leishmania is transmitted in the presence of sand fly saliva. Protective immunity generated by saliva has encouraged identification of a vector salivary-based vaccine. Previous studies have shown that immunization with LJM11, a salivary protein from Lutzomyia longipalpis, is able to induce a Th1 immune response and protect mice against bites of Leishmania major-infected Lutzomyia longipalpis. Read More

    The Akt-like kinase of Leishmania panamensis: As a new molecular target for drug discovery.
    Acta Trop 2018 Jan 14;177:171-178. Epub 2017 Oct 14.
    PECET, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 # 52-21, Medellín, Colombia; Facultad de Ciencias Básicas, Grupo (QUIBIO), Universidad Santiago de Cali, Cali, Colombia. Electronic address:
    The Akt-like kinase of Leishmania spp. is a cytoplasmic orthologous protein of the serine/threonine kinase B-PKB/human-Akt group, which is involved in the cellular survival of these parasites. By the application of a computational strategy we obtained two specific inhibitors of the Akt-like protein of L. Read More

    Quality of anthelminthic medicines available in Jimma Ethiopia.
    Acta Trop 2018 Jan 13;177:157-163. Epub 2017 Oct 13.
    Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. Electronic address:
    Soil-transmitted helminthiasis and schistosomiasis are major public health problems in Ethiopia. Mass deworming of at-risk population using a single dose administration of 400mg albendazole (ABZ) or 500mg mebendazole (MBZ) for treatment of common intestinal worms and 40mg of praziquantel (PZQ) per kg body weight for treatment of schistosomiasis is one of the strategies recommended by World Health Organization (WHO) in order to control the morbidity of soil-transmitted helminthiasis and schistosomiasis. Since storage condition, climate, way of transportation and distribution route could all affect the quality of medicines, regular assessment by surveys is very critical to ensure the therapeutic outcome, to minimize risk of toxicity to the patient and resistance of parasites. Read More

    Genetic variability and transcontinental sharing of Giardia duodenalis infrapopulations determined by glutamate dehydrogenase gene.
    Acta Trop 2018 Jan 13;177:146-156. Epub 2017 Oct 13.
    Department of Medical Parasitology and Mycology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
    Microevolutionary data of Giardia duodenalis sub-assemblages is a prerequisite for determining the invasion zoonotic patterns of the parasite. To infer transmission patterns that could not be differentiated by the phenotypic features, a population genetic investigation is crucial for the elucidation of the genetic structure of G. duodenalis among the continents. Read More

    Investigation of infectious reproductive pathogens of large ruminants: Are neosporosis, brucellosis, leptospirosis and BVDV of relevance in Lao PDR?
    Acta Trop 2018 Jan 9;177:118-126. Epub 2017 Oct 9.
    The University of Sydney, Sydney School of Veterinary Science, 425 Werombi Road, Camden, NSW 2570, Australia.
    N. caninum, bovine viral diarrhoea virus, Brucella abortus and Leptospira interrogans serovar Hardjo are globally significant reproductive pathogens that cause abortion and reproductive loss in large ruminants. Prevalence information is lacking in Lao People's Democratic Republic (Laos) despite the poor reproductive performance of cattle and buffalo. Read More

    Molecular confirmation of Hepatozoon canis in Mauritius.
    Acta Trop 2018 Jan 9;177:116-117. Epub 2017 Oct 9.
    Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăștur nr. 3-5, 400372, Cluj-Napoca, Romania. Electronic address:
    In this study, Hepatozoon species was molecularly identified and characterized for the first time on the Indian Ocean island of Mauritius. Partial sequences of the 18S rRNA gene of the Hepatozoon isolates were analysed from three naturally infected dogs. The sequences of H. Read More

    Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador: the causative Leishmania parasites and clinico-epidemiological features.
    Acta Trop 2018 Jan 7;177:135-145. Epub 2017 Oct 7.
    Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
    This study provides comprehensive information on the past and current status of the Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador, mainly focusing on the causative Leishmania parasites and clinico-epidemiological features. Available information and data including our unpublished works were analyzed thoroughly. Endemic regions of the Andean-CL (uta) in Peru run from the north Piura/Cajamarca to the south Ayacucho at a wide range of the Pacific watersheds of the Andes through several departments, while in Ecuador those exist at limited and spotted areas in the country's mid-southwestern two provinces, Azuay and Chimborazo. Read More

    Therapeutic efficacy of artesunate - amiodaquine for treating uncomplicated falciparum malaria at Ghindae Zonal Referral Hospital, Eritrea.
    Acta Trop 2018 Jan 7;177:94-96. Epub 2017 Oct 7.
    Asmara College of Health Sciences, Asmara, Eritrea.
    Introduction: The aim of this study was to assess the efficacy of artesunate-amodiaquine (AS+AQ) which is the first-line treatment for uncomplicated falciparum malaria in Eritrea.

    Materials And Methods: The study was conducted from December 2014 to March 2015 in Ghindae Zonal Referral Hospital in Northern Red Sea Zone. Out of 481 patients screened, 103 were enrolled in the study. Read More

    Animal and human tungiasis-related knowledge and treatment practices among animal keeping households in Bugiri District, South-Eastern Uganda.
    Acta Trop 2018 Jan 7;177:81-88. Epub 2017 Oct 7.
    Institute of Microbiology and Hygiene, Charité University Medicine, Berlin Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
    Background: Zoonotic tungiasis caused by Tunga penetrans remains a serious public and animal health problem among endemic villages in Uganda and many sub Saharan African countries. Studies on human and animal tungiasis-related knowledge and treatment practices in endemic communities have never been undertaken, a limitation to development of sustainable control measures.

    Methods: A cross sectional study using semi-structured questionnaires (Supplementary file S1) was conducted among 236 animal rearing households in 10 endemic villages in Bugiri District, South-Eastern Uganda. Read More

    Hierarchical dynamics influence the distribution of immature black flies (Diptera: Simuliidae).
    Acta Trop 2018 Jan 7;177:105-115. Epub 2017 Oct 7.
    Department of Biochemistry, School of Life Sciences, Central University of Rajasthan, Ajmer, 305817, Rajasthan, India.
    Adult black flies (Simuliidae) are medically important insects and they are the sole vector of Onchocerca volvulus. Immature black flies are major components of aquatic macroinvertebrate assemblages in streams and play a vital role in nutrient dynamics. In this study, we examined effect of hierarchical dynamics (spatio-temporal pattern) on the distribution of immature black flies in South Indian streams. Read More

    Spatial and temporal distribution of Pfmsp1 and Pfmsp2 alleles and genetic profile change of Plasmodium falciparum populations in Gabon.
    Acta Trop 2017 Oct 7;178:27-33. Epub 2017 Oct 7.
    Faculty of Medicine, Department of Parasitology and Mycology, University des Sciences de la Santé, BP 4009, Libreville, Gabon. Electronic address:
    Plasmodium population dynamics analysis may help to assess the impact of malaria control strategies deployment. In Gabon, new strategies have been introduced, but malaria is still a public health problem marked by a rebound of the prevalence in 2011. The aim of the study was to investigate the spatial and temporal distribution of P. Read More

    Presence of Borrelia spp. DNA in ticks, but absence of Borrelia spp. and of Leptospira spp. DNA in blood of fever patients in Madagascar.
    Acta Trop 2018 Jan 3;177:127-134. Epub 2017 Oct 3.
    University Medical Center, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany. Electronic address:
    The occurrence of tick-borne relapsing fever and leptospirosis in humans in Madagascar remains unclear despite the presence of their potential vectors and reservoir hosts. We screened 255 Amblyomma variegatum ticks and 148 Rhipicephalus microplus ticks from Zebu cattle in Madagascar for Borrelia-specific DNA. Borrelia spp. Read More

    The roles of galectins in parasitic infections.
    Acta Trop 2018 Jan 3;177:97-104. Epub 2017 Oct 3.
    Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China; Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, Guangdong, China; Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou 510080, Guangdong, China. Electronic address:
    Galectins is a family of multifunctional lectins. Fifteen galectins have been identified from a variety of cells and tissues of vertebrates and invertebrates. Galectins have been shown to play pivotal roles in host-pathogen interaction such as adhesion of pathogens to host cells and activation of host innate and adaptive immunity. Read More

    The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic.
    Acta Trop 2018 Jan 3;177:58-65. Epub 2017 Oct 3.
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 301 University Boulevard Galveston, TX 77555-0609, United States. Electronic address:
    The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and -3 were predominant. Read More

    Sero-epidemiology and hemato-biochemical study of bovine leptospirosis in flood affected zone of Pakistan.
    Acta Trop 2018 Jan 2;177:51-57. Epub 2017 Oct 2.
    Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, 54600, Pakistan.
    The bovine leptospirosis is an economically important zoonotic disease of flood affected areas worldwide, but scarce information is available about its epidemiology in Pakistan. This is a first study on sero-epidemiology of bovine leptospirosis in Pakistan. The objectives of this study were to investigate the sero-prevalence and associated risk factors of bovine leptospirosis in flood affected zone of Punjab, Pakistan. Read More

    Zika and Chikungunya virus detection in naturally infected Aedes aegypti in Ecuador.
    Acta Trop 2018 Jan 2;177:74-80. Epub 2017 Oct 2.
    Instituto Nacional de Investigación en Salud Pública, Centro de Investigación y Referencia Nacional en Vectores, Quito, Ecuador.
    The wide and rapid spread of Chikungunya (CHIKV) and Zika (ZIKV) viruses represent a global public health problem, especially for tropical and subtropical environments. The early detection of CHIKV and ZIKV in mosquitoes may help to understand the dynamics of the diseases in high-risk areas, and to design data based epidemiological surveillance to activate the preparedness and response of the public health system and vector control programs. This study was done to detect ZIKV and CHIKV viruses in naturally infected fed female Aedes aegypti (L. Read More

    Evaluating the anti-leishmania activity of Lucilia sericata and Sarconesiopsis magellanica blowfly larval excretions/secretions in an in vitro model.
    Acta Trop 2018 Jan 2;177:44-50. Epub 2017 Oct 2.
    Medical and Forensic Entomology Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá DC, Colombia; Medicine Faculty, Universidad Antonio Nariño, Bogotá DC, Colombia; Faculty of Agricultural and Livestock Sciences, Universidad de La Salle, Bogotá DC, Colombia. Electronic address:
    Leishmaniasis is a vector-borne disease caused by infection by parasites from the genus Leishmania. Clinical manifestations can be visceral or cutaneous, the latter mainly being chronic ulcers. This work was aimed at evaluating Calliphoridae Lucilia sericata- and Sarconesiopsis magellanica-derived larval excretions and secretions' (ES) in vitro anti-leishmanial activity against Leishmania panamensis. Read More

    The applicability of real-time PCR in the diagnostic of cutaneous leishmaniasis and parasite quantification for clinical management: Current status and perspectives.
    Acta Trop 2017 Sep 29. Epub 2017 Sep 29.
    Laboratório de Pesquisas em Leishmanioses, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil. Electronic address:
    Cutaneous leishmaniasis (CL) is spread worldwide and is the most common manifestation of leishmaniasis. Diagnosis is performed by combining clinical and epidemiological features, and through the detection of Leishmania parasites (or DNA) in tissue specimens or trough parasite isolation in culture medium. Diagnosis of CL is challenging, reflecting the pleomorphic clinical manifestations of this disease. Read More

    Advantages of bioconjugated silica-coated nanoparticles as an innovative diagnosis for human toxoplasmosis.
    Acta Trop 2018 Jan 28;177:19-24. Epub 2017 Sep 28.
    Hydrobiology Department, National Research Centre, Dokki, Giza, Egypt; Biology Dept., Girls Science College, Imam Abdulrahman Bin Faisal University, Saudi Arabia. Electronic address:
    Nanotechnology is a promising arena for generating new applications in Medicine. To successfully functionalised nanoparticles for a given biomedical application, a wide range of chemical, physical and biological factors have to be taken into account. Silica-coated nanoparticles, (SiO2NP) exhibit substantial diagnostic activity owing to their large surface to volume ratios and crystallographic surface structure. Read More

    Aspects on the ecology of phlebotomine sand flies and natural infection by Leishmania hertigi in the Southeastern Amazon Basin of Brazil.
    Acta Trop 2018 Jan 28;177:37-43. Epub 2017 Sep 28.
    Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil.
    The medical and veterinary importance of sand flies (Diptera: Psychodidae) follow as a result of some species ability to transmit the zoonotic protozoa of the genus Leishmania. Of all municipalities in the state of Mato Grosso, Sinop ranks first in reported cases of American Cutaneous Leishmaniasis (ACL). Sinop urban zone encompasses three permanent forest preservation areas (APPs) that provide refuge for insects and other vertebrate hosts. Read More

    Clinical, laboratory, and demographic determinants of hospitalization due to dengue in 7613 patients: A retrospective study based on hierarchical models.
    Acta Trop 2018 Jan 28;177:25-31. Epub 2017 Sep 28.
    Laboratório de Pesquisa em Virologia, Faculdade de Medicina de São José do Rio Preto, Brigadeiro Faria Lima Avenue, 5416. Vila São Pedro, 15090-000, São José do Rio Preto, SP, Brazil. Electronic address:
    In Brazil, the incidence of hospitalization due to dengue, as an indicator of severity, has drastically increased since 1998. The objective of our study was to identify risk factors associated with subsequent hospitalization related to dengue. We analyzed 7613 dengue confirmed via serology (ELISA), non-structural protein 1, or polymerase chain reaction amplification. Read More

    Natural infection of Ctenodactylus gundi by Leishmania major in Tunisia.
    Acta Trop 2018 Jan 28;177:89-93. Epub 2017 Sep 28.
    Department of Medical Epidemiology, Institut Pasteur de Tunis, 13, Place Pasteur, BP 74 1002, Tunis-Belvédère, Tunisia; Laboratory of Transmission, Control and Immunobiology of Infections (LR11IPT02), Institut Pasteur de Tunis, 13, Place Pasteur, BP 74 1002, Tunis-Belvédère, Tunisia; Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia; Department of Family and Community Medicine, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama, Bahrain. Electronic address:
    Incriminating new rodent species, as reservoir hosts of Leishmania parasites is crucial for understanding the transmission cycle of cutaneous leishmaniasis in Tunisia. Ctenodactylus (C.) gundi was previously described as extremely abundant in all Tunisian Leishmania (L. Read More

    Regional and seasonal effects on the gastrointestinal parasitism of captive forest musk deer.
    Acta Trop 2018 Jan 28;177:1-8. Epub 2017 Sep 28.
    Laboratory of Non-invasive Research Technology for Endangered Species, College of Nature Conservation, Beijing Forestry University, No. 35 Tsinghua East Road, Haidian District, Beijing 100083, China. Electronic address:
    Parasite infections can cause adverse effects on health, survival and welfare of forest musk deer. However, few studies have quantified the parasite infection status and evaluated the parasite temporal dynamics and differences between breeding centers for captive forest musk deer. The purpose of this study was to assess seasonal and regional effects on the parasite prevalence, shedding capacity, diversity, aggregation and infracommunity to establish baseline data on captive forest musk deer. Read More

    Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity.
    Acta Trop 2017 Sep 21. Epub 2017 Sep 21.
    Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Avenida Professor Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil. Electronic address:
    The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs), TcI-TcVI and Tcbat. Read More

    Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil.
    Acta Trop 2017 Dec 21;176:455-462. Epub 2017 Sep 21.
    Division of Dermatology, Department of Clinical Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:
    Background: Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil.

    Purpose: To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases in the northeastern region of São Paulo State, and to assess the humoral immune response against salivary gland extracts (SGEs) from biting flies in PF patients, relatives, and neighbours.

    Methods: PF patients' medical information recorded between 1965 and 2014 were obtained from the database of the University Hospital. Read More

    3D modelling of the pathogenic Leptospira protein LipL32: A bioinformatics approach.
    Acta Trop 2017 Dec 21;176:433-439. Epub 2017 Sep 21.
    Department of Medical Microbiology and Parasitology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. Electronic address:
    Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species (Leptospiraceae). LipL32 is an abundant lipoprotein from the outer membrane proteins (OMPs) group, highly conserved among pathogenic and intermediate Leptospira species. Several studies used LipL32 as a specific gene to identify the presence of leptospires. Read More

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