674,854 results match your criteria Acta radiologica Stockholm Sweden : 1987[Journal]


Cu-selective NIR fluorescence sensor based on heptamethine cyanine in aqueous media and its application.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;240:118606. Epub 2020 Jun 19.

Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address:

A near-infrared (NIR) colorimetric fluorescence sensor, Cy7C3, based on heptamethine cyanine dye was synthesized for determining the presence of Cu ions. The sensor showed highly sensitive fluorescence quenching toward Cu ions in acetonitrile/buffer solution at physiological pH with long emission wavelength of 718 nm. Cy7C3 also provided an excellent selectivity to Cu ions over other competing metal ions, with a low detection limit of 9 ppb, which was lower than the maximum concentration of Cu ions in drinking water of U. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118606DOI Listing

A FRET-based ratiometric fluorescent probe for highly selective detection of hydrogen polysulfides based on a coumarin-rhodol derivative.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 29;241:118650. Epub 2020 Jun 29.

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.

In modern biology, hydrogen polysulfides (HS, n > 1) are members of reactive sulfur species (RSS), with anti-oxidation, cell protection and redox signals in tissues and organs. Therefore, it is crucial to develop a method to monitor the changes of HS level in organisms. We designed and synthesized a ratiometric fluorescent probe for highly selective detection of HS based on the fluorescence resonance energy transfer (FRET) process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118650DOI Listing

Platinum (II)-doped graphitic carbon nitride with enhanced peroxidase-like activity for detection of glucose and HO.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 26;241:118649. Epub 2020 Jun 26.

Institute of Pharmacy and Pharmacology, University of South China, HengYang 421000, Hunan, China. Electronic address:

A platinum (II)-doped graphitic carbon nitride (Pt@g-CN) nanozyme was prepared in this work. Compared to g-CN, Pt@g-CN shows enhanced peroxidase-like activity. According to DFT calculations and ESR measurements, the Pt on the surface of g-CN accelerates the decomposition of HO into OH and consequently accelerates TMB oxidation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118649DOI Listing

Synthesis, structural, spectral and antimicrobial activity studies of copper-nalidixic acid complex with 1,10-phenanthroline: DFT and molecular docking.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 25;241:118639. Epub 2020 Jun 25.

Ondokuz Mayıs University, Faculty of Arts and Sciences, Physics Department, Samsun, Turkey.

The mix-ligand coordination compound, [Cu(Nal)(Phen)(HO)].(Phen).ClO. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2020.118639DOI Listing

Cognitive capacity in self-directed learning: Evidence of middle school students' executive attention to resist distraction.

Acta Psychol (Amst) 2020 Jul 3;209:103089. Epub 2020 Jul 3.

School of Educational Sciences, Tallinn University, Narva road 25, 10120 Tallinn, Estonia. Electronic address:

Self-directed learning (SDL) is a rapidly developing trend in schools, although its prerequisites, such as children's skills and abilities to plan and monitor their own learning, have not been investigated in detail. Due to additional cognitive load it induces, SDL has been in some cases found to be detrimental for learning, especially for students with a lower cognitive capacity. With this study, we explored some of the causes for the variability in learning gains. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actpsy.2020.103089DOI Listing

Improvement of organisms by biomimetic mineralization: a material incorporation strategy for biological modification.

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, 310027 China; Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, 310027 China. Electronic address:

Biomineralization, a bio-organism controlled mineral formation process, plays an important role in linking biological organisms and mineral materials in nature. Inspired by biomineralization, biomimetic mineralization is used as a bridge tool to integrate biological organisms and functional materials together, which can be beneficial for the development of diversified functional organism-material hybrids. In this review, recent progresses on the techniques of biomimetic mineralization for organism-material combinations are summarized and discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.06.038DOI Listing

X-ray and NIR Light Dual-triggered Mesoporous Upconversion Nanophosphor/Bi Heterojunction Radiosensitizer for Highly Efficient Tumor Ablation.

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Institute of Bismuth Science, College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

Developing a multi-functional radiosensitizer with high efficiency and low toxicity remains challenging. Herein, we report a mesoporous heterostructure radiosensitizer (UCNP@NBOF-FePc-PFA) containing Lu-based upconversion nanophosphor (UCNP) and Bi-based nanomaterial loaded with iron phthalocyanine for X-ray and NIR light dual-triggered tri-modal tumor therapy. NaLuF:Yb,Tm, a Lu-based UCNP, offers radiosensitization and upconversion luminescence for optical bio-imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.06.044DOI Listing

Engineering the Cellular Mechanical Microenvironment to Regulate Stem Cell Chondrogenesis: Insights from a Microgel Model.

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P. R. China; Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510641, China. Electronic address:

Biophysical cues (especially mechanical cues) embedded in cellular microenvironments show a critical impact on stem cell fate. Despite the capability of traditional hydrogels to mimic the feature of extracellular matrix (ECM) and tune their physicochemical properties via diverse approaches, their relatively large size not only induces biased results, but also hinders high-throughput screening and analysis. In this paper, a microgel model is proposed to recapitulate the role of 3D mechanical microenvironment on stem cell behaviors especially chondrogenesis in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actbio.2020.06.046DOI Listing

Altered expressions and splicing profiles of Acin1 transcripts differentially modulate brown adipogenesis through an alternative splicing mechanism.

Biochim Biophys Acta Gene Regul Mech 2020 Jul 3:194601. Epub 2020 Jul 3.

School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; PhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:

Apoptotic chromatin condensation inducer in the nucleus (also referred as Acin1) was first characterized as an RNA-binding protein involved in apoptosis. In later reports, Acin1 was identified as an auxiliary component of the exon junction complex (EJC) which is assembled throughout pre-messenger RNA splicing. In this study, results of whole-transcriptome analyses revealed reduced expressions and reprogrammed splicing profiles of Acin1 transcripts throughout development of brown adipose tissues (BATs) that execute non-shivering thermogenesis in small rodents and infants by consuming lipids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagrm.2020.194601DOI Listing

Identification of human glycerophosphodiesterase 3 as an ecto phospholipase C that converts the G protein-coupled receptor 55 agonist lysophosphatidylinositol to bioactive monoacylglycerols in cultured mammalian cells.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 3:158761. Epub 2020 Jul 3.

Graduate School of Biomedical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan; Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan. Electronic address:

A family of glycerol-based lysolipid mediators comprises lysophosphatidic acid as a representative phospholipidic member but also a monoacylglycerol as a non-phosphorus-containing member. These critical lysolipid mediators are known to be produced from different lysophospholipids by actions of lysophospholipases C and D in mammals. Some members of the glycerophosphodiesterase (GDE) family have attracted recent attention due to their phospholipid-metabolizing activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2020.158761DOI Listing

Gene expression of endocannabinoid system in HIV-1-related neuropathic pain model.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 3:165891. Epub 2020 Jul 3.

Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2020.165891DOI Listing

Biotin Sulfoxide is an Interferent in Several Roche cobas e411 Immunoassays.

Clin Chim Acta 2020 Jul 3. Epub 2020 Jul 3.

Department of Pathology, University of Virginia School of Medicine, Charlottesville VA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2020.06.050DOI Listing

Miltefosine inhibits the membrane remodeling caused by phospholipase action by changing membrane physical properties.

Biochim Biophys Acta Biomembr 2020 Jul 3:183407. Epub 2020 Jul 3.

Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address:

Miltefosine (hexadecylphosphocholine or HePC) is an alkylphosphocholine approved for the treatment of visceral and cutaneous Leishmaniasis. HePC exerts its effect by interacting with lipid membranes and affecting membrane-dependent processes. The molecular geometry of HePC suggests that the pharmacological function of HePC is to alter membrane curvature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamem.2020.183407DOI Listing

Anti-amoebic potential of azole scaffolds and nanoparticles against pathogenic Acanthamoeba.

Acta Trop 2020 Jul 3:105618. Epub 2020 Jul 3.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.

Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2020.105618DOI Listing

Severity of retinopathy of prematurity was associated with a higher risk of cerebral dysfunction in young adults born extremely preterm.

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Women´s and Children`s Health, Karolinska Institute, Stockholm, Sweden.

Aim: This Swedish study evaluated whether the severity of retinopathy of prematurity (ROP) in extremely preterm infants was related to their overall outcome in young adulthood.

Methods: We followed 39 individuals born 1988-93 at less than 28 gestational weeks, included in the Stockholm Neonatal Project. 19 were treated for severe ROP and 20 had no or mild ROP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15461DOI Listing

Setting realistic goals for feeding infants when their mothers have suspected or confirmed COVID-19.

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics (Neonatal Division), McMaster University, Hamilton, Ontario, Canada.

The pandemic is a stressful time for everyone, including mothers and healthcare providers who are concerned about the best and safest way to feed babies born to mothers with suspected or confirmed COVID-19. There is lack of consensus regarding mother-infant contact, unless the mother definitely has COVID-19 and even then there is a distinct lack of data to devise protocols for everyday clinical practice.. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15459DOI Listing

Involvement of clinical characteristics and HLA-DQ2 genotypes in paediatric patients with coeliac disease suffering from allergies.

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Immunology Section, Ciudad Real University General Hospital, Ciudad Real, Spain.

The first description on the association of coeliac disease (CD) with allergic conditions dates in the 1970s, when was found the co-occurrence of asthma, eczema and rhinitis in adult patients with CD. Later, this likely connection was screened both in paediatric and adult populations, although with conflicting results (1,2). Hence, the relationship between CD and allergy is scarcely known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15460DOI Listing

Neuromuscular responses to fatiguing locomotor exercise.

Acta Physiol (Oxf) 2020 Jul 6:e13533. Epub 2020 Jul 6.

Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Over the last two decades, an abundance of research has explored the impact of fatiguing locomotor exercise on the neuromuscular system. Neurostimulation techniques have been implemented prior to and following locomotor exercise tasks of a wide variety of intensities, durations, and modes. These techniques have allowed for the assessment of alterations occurring within the central nervous system and the muscle, while techniques such as transcranial magnetic stimulation and spinal electrical stimulation have permitted further segmentalisation of locomotor exercise-induced changes along the motor pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13533DOI Listing

Evidence-based Anti-seizure Monotherapy in Newly Diagnosed Epilepsy: a New Approach.

Acta Neurol Scand 2020 Jul 6. Epub 2020 Jul 6.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Clinical Sciences Helsingborg, Sweden.

Objectives: To describe the process and results of the updated Swedish practice guidelines for monotherapy in epilepsy.

Materials And Methods: The Swedish Medical Products Agency led the process together with medical experts. Evidence rating in accordance with the International League Against Epilepsy (ILAE) template was linked to the Cochrane group's Grade system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13312DOI Listing

Proline/alanine-rich sequence (PAS) polypeptides as an alternative to PEG precipitants for protein crystallization.

Acta Crystallogr F Struct Biol Commun 2020 Jul 1;76(Pt 7):320-325. Epub 2020 Jul 1.

Lehrstuhl für Biologische Chemie, Technische Universität München, 85354 Freising, Germany.

Proline/alanine-rich sequence (PAS) polypeptides represent a novel class of biosynthetic polymers comprising repetitive sequences of the small proteinogenic amino acids L-proline, L-alanine and/or L-serine. PAS polymers are strongly hydrophilic and highly soluble in water, where they exhibit a natively disordered conformation without any detectable secondary or tertiary structure, similar to polyethylene glycol (PEG), which constitutes the most widely applied precipitant for protein crystallization to date. To investigate the potential of PAS polymers for structural studies by X-ray crystallography, two proteins that were successfully crystallized using PEG in the past, hen egg-white lysozyme and the Fragaria × ananassa O-methyltransferase, were subjected to crystallization screens with a 200-residue PAS polypeptide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X20008328DOI Listing

A proposed carbon-utilization and virulence protein A, CuvA (Rv1422), from Mycobacterium tuberculosis H37Rv: crystallization, X-ray diffraction analysis and ligand binding.

Acta Crystallogr F Struct Biol Commun 2020 Jul 1;76(Pt 7):314-319. Epub 2020 Jul 1.

Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Republic of Korea.

Mycobacterium tuberculosis possesses the ability to undergo physiological adaptations in order to persist during the prolonged course of infection despite the active immune response of the host and in order to overcome multiple environmental changes. Previous studies have proposed that M. tuberculosis CuvA (Rv1422; MtCuvA) might play a critical role in the adaptation of the bacterium to environmental changes, such as nutrient utilization and alteration of the growth rate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X20008626DOI Listing

Structural characterization of borneol dehydrogenase from Pseudomonas sp. TCU-HL1.

Acta Crystallogr F Struct Biol Commun 2020 Jul 1;76(Pt 7):309-313. Epub 2020 Jul 1.

Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.

During the microbial degradation of borneol, a bicyclic plant monoterpene, it is first converted into camphor by borneol dehydrogenase (BDH) and then enters a known camphor-degradation pathway. Previously, a recombinant Pseudomonas BDH was found in inclusion bodies when expressed in Escherichia coli. After refolding, it was still unstable and was difficult to concentrate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X20008584DOI Listing

Tartryl-CoA inhibits succinyl-CoA synthetase.

Acta Crystallogr F Struct Biol Commun 2020 Jul 1;76(Pt 7):302-308. Epub 2020 Jul 1.

Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.

Succinyl-CoA synthetase (SCS) catalyzes the only substrate-level phosphorylation step in the tricarboxylic acid cycle. Human GTP-specific SCS (GTPSCS), an αβ-heterodimer, was produced in Escherichia coli. The purified protein crystallized from a solution containing tartrate, CoA and magnesium chloride, and a crystal diffracted to 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X20008201DOI Listing

Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase.

Acta Crystallogr F Struct Biol Commun 2020 Jul 1;76(Pt 7):292-301. Epub 2020 Jul 1.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.

Mammalian pyruvate dehydrogenase (PDH) activity is tightly regulated by phosphorylation and dephosphorylation, which is catalyzed by PDH kinase isomers and PDH phosphatase isomers, respectively. PDH phosphatase isomer 1 (PDP1) is a heterodimer consisting of a catalytic subunit (PDP1c) and a regulatory subunit (PDP1r). Here, the crystal structure of bovine PDP1c determined at 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X20007943DOI Listing

Innovation versus practice in biological crystallization.

Acta Crystallogr F Struct Biol Commun 2020 Jul 2;76(Pt 7):290-291. Epub 2020 Jul 2.

Department of Molecular Structure, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, E-28049, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053230X20008869DOI Listing

Rosalind Franklin 1920-1958.

Authors:
Elspeth F Garman

Acta Crystallogr D Struct Biol 2020 Jul 2;76(Pt 7):698-701. Epub 2020 Jul 2.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320008827DOI Listing

Structure of apo flavin-dependent halogenase Xcc4156 hints at a reason for cofactor-soaking difficulties.

Acta Crystallogr D Struct Biol 2020 Jul 30;76(Pt 7):687-697. Epub 2020 Jun 30.

Structural Biochemistry (BCIV), Department of Chemistry, Bielefeld University, Universitaetsstrasse 25, 33615 Bielefeld, Germany.

Flavin-dependent halogenases regioselectively introduce halide substituents into electron-rich substrates under mild reaction conditions. For the enzyme Xcc4156 from Xanthomonas campestris, the structure of a complex with the cofactor flavin adenine dinucleotide (FAD) and a bromide ion would be of particular interest as this enzyme exclusively brominates model substrates in vitro. Apo Xcc4156 crystals diffracted to 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320007731DOI Listing

Structural and biochemical characterization of novel carbonic anhydrases from Phaeodactylum tricornutum.

Acta Crystallogr D Struct Biol 2020 Jul 30;76(Pt 7):676-686. Epub 2020 Jun 30.

School of Biological Science, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

Carbonic anhydrases (CAs) are a well characterized family of metalloenzymes that are highly efficient in facilitating the interconversion between carbon dioxide and bicarbonate. Recently, CA activity has been associated with the LCIB (limiting CO-inducible protein B) protein family, which has been an interesting target in aquatic photosynthetic microorganisms. To gain further insight into the catalytic mechanism of this new group of CAs, the X-ray structure of a highly active LCIB homolog (PtLCIB3) from the diatom Phaeodactylum tricornutum was determined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320007202DOI Listing

Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel.

Acta Crystallogr D Struct Biol 2020 Jul 30;76(Pt 7):668-675. Epub 2020 Jun 30.

Unité Dynamique Structurale des Macromolécules, Institut Pasteur, 25 Rue du Docteur Roux, F-75015 Paris, France.

GLIC is a bacterial homologue of the pentameric ligand-gated ion channels (pLGICs) that mediate the fast chemical neurotransmission of nerve signalling in eukaryotes. Because the activation and allosteric modulation features are conserved among prokaryotic and eukaryotic pLGICs, GLIC is commonly used as a model to study the allosteric transition and structural pharmacology of pLGICs. It has previously been shown that GLIC is inhibited by some carboxylic acid derivatives. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S205979832000772XDOI Listing

A new modulated crystal structure of the ANS complex of the St John's wort Hyp-1 protein with 36 protein molecules in the asymmetric unit of the supercell.

Acta Crystallogr D Struct Biol 2020 Jul 17;76(Pt 7):653-667. Epub 2020 Jun 17.

Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.

Superstructure modulation, with violation of the strict short-range periodic order of consecutive crystal unit cells, is well known in small-molecule crystallography but is rarely reported for macromolecular crystals. To date, one modulated macromolecular crystal structure has been successfully determined and refined for a pathogenesis-related class 10 protein from Hypericum perforatum (Hyp-1) crystallized as a complex with 8-anilinonaphthalene-1-sulfonate (ANS) [Sliwiak et al. (2015), Acta Cryst. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320006841DOI Listing

Making a difference in multi-data-set crystallography: simple and deterministic data-scaling/selection methods.

Acta Crystallogr D Struct Biol 2020 Jul 17;76(Pt 7):636-652. Epub 2020 Jun 17.

Department of Biology, University of Konstanz, Box 647, D-78457 Konstanz, Germany.

Phasing by single-wavelength anomalous diffraction (SAD) from multiple crystallographic data sets can be particularly demanding because of the weak anomalous signal and possible non-isomorphism. The identification and exclusion of non-isomorphous data sets by suitable indicators is therefore indispensable. Here, simple and robust data-selection methods are described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320006348DOI Listing

Macromolecular crystallography beamlines at the Canadian Light Source: building on success.

Acta Crystallogr D Struct Biol 2020 Jul 19;76(Pt 7):630-635. Epub 2020 Jun 19.

Canadian Macromolecular Crystallography Facility, Canadian Light Source, 44 Innovation Boulevard, Saskatoon, SK S7N 2V3, Canada.

The Canadian Macromolecular Crystallography Facility (CMCF) consists of two beamlines dedicated to macromolecular crystallography: CMCF-ID and CMCF-BM. After the first experiments were conducted in 2006, the facility has seen a sharp increase in usage and has produced a significant amount of data for the Canadian crystallographic community. Upgrades aimed at increasing throughput and flux to support the next generation of more demanding experiments are currently under way or have recently been completed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320007603DOI Listing

Targeting the innate immune receptor TLR8 using small-molecule agents.

Acta Crystallogr D Struct Biol 2020 Jul 17;76(Pt 7):621-629. Epub 2020 Jun 17.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atomic insights into structures of TLR8 complexed with various agonists or antagonists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320006518DOI Listing

Two particle-picking procedures for filamentous proteins: SPHIRE-crYOLO filament mode and SPHIRE-STRIPER.

Acta Crystallogr D Struct Biol 2020 Jul 17;76(Pt 7):613-620. Epub 2020 Jun 17.

Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

Structure determination of filamentous molecular complexes involves the selection of filaments from cryo-EM micrographs. The automatic selection of helical specimens is particularly difficult, and thus many challenging samples with issues such as contamination or aggregation are still manually picked. Here, two approaches for selecting filamentous complexes are presented: one uses a trained deep neural network to identify the filaments and is integrated in SPHIRE-crYOLO, while the other, called SPHIRE-STRIPER, is based on a classical line-detection approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320007342DOI Listing

Three new Co-editors appointed to Acta Crystallographica Section D, Structural Biology.

Acta Crystallogr D Struct Biol 2020 Jul 2;76(Pt 7):612. Epub 2020 Jul 2.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2059798320008815DOI Listing

-associated myocarditis mimicking acute myocardial infarction.

Acta Clin Belg 2020 Jul 4:1-6. Epub 2020 Jul 4.

Department of Cardiology, Brugmann University Hospital , Brussels, Belgium.

Background Trichinellosis is a parasitic infection caused by nematodes of the genus , and its principal mode of transmission is the consumption of raw or undercooked contaminated meat. Cardiac involvement in trichinellosis is unusual, yet it represents the most frequent cause of death. Here, we report a case in which -associated myocarditis simulated a myocardial infarction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17843286.2020.1790867DOI Listing

Bibliometrics for 2019: For the third year in row, the impact factor is between five and six.

Authors:
Pontus B Persson

Acta Physiol (Oxf) 2020 Jul 5:e13534. Epub 2020 Jul 5.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.

Citations to Acta Physiologica increase dramatically, reflecting the quality of the studies published. The buildup of citations to Acta Physiologica since 2008 is seen in Figure 1. The 2019 ranking of Acta Physiologica remains constant, topping the list of those journals that publish articles from the entire field of physiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13534DOI Listing

Ranibizumab-The jury is still out.

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Neonatal Medicine, Women's and Children's Hospital, North Adelaide, SA, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15256DOI Listing

Pills to think about in allergic rhinitis children during COVID-19 era.

Acta Paediatr 2020 Jul 5. Epub 2020 Jul 5.

Department of Pediatrics, Sapienza University of Rome, Rome, 00161, Italy.

Allergic rhinitis (AR) is a common pediatric disease, that involves up to the 25% of children worldwide. Environmental pollution, passive smoke, and many viruses are actively involved in the chronic inflammation of the nasal mucosa. As described previously in the literature, novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children is uncommon and often asymptomatic or mild. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.15462DOI Listing

Corrigendum.

Authors:

Acta Neurol Scand 2020 Aug;142(2):187

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13262DOI Listing

Prenatal tobacco exposure and psychiatric outcomes in adolescence: is the effect mediated through birth weight?

Acta Psychiatr Scand 2020 Jul 6. Epub 2020 Jul 6.

Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland.

Objective: This study aims to examine the associations between prenatal exposure to maternal smoking, birthweight and persistent offspring psychiatric symptoms. Additionally we aim to examine whether the relationship between prenatal maternal smoking and persistent offspring psychiatric symptoms is mediated by offspring birthweight.

Methods: This study used the Growing Up in Ireland (GUI) longitudinal cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acps.13210DOI Listing

Adherence to Clozapine vs. Other Antipsychotics in Schizophrenia.

Acta Psychiatr Scand 2020 Jul 6. Epub 2020 Jul 6.

Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Canada, Ontario.

Background: To date, there have been no studies evaluating adherence to clozapine with electronic adherence monitoring (EAM) such as the Medication Event Monitoring System (MEMS®).

Methods: In outpatients with schizophrenia, we conducted a 3-month prospective study investigating antipsychotic adherence with EAM (eCAP®). Participants were treated with different oral antipsychotics, including clozapine, and blind to EAM monitoring; all were on antipsychotic monotherapy administered once daily. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acps.13208DOI Listing

Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis.

Scand J Work Environ Health 2020 Jul 6. Epub 2020 Jul 6.

Health Sciences, Exponent, Inc., 149 Commonwealth Drive, Menlo Park, California, 94025, USA.

As the first case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis (mTVT), the paper by Marinaccio et al (1) is potentially an important epidemiologic contribution. A careful review of the paper, however, raises a number of methodological issues. Any case-control study can be viewed as being nested within a conceptual cohort, with controls being sampled from the at-risk cohort as cases arise over time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5271/sjweh.3909DOI Listing

Immunohistochemical Pharmacokinetics of the Anti-diabetes Drug Alogliptin in Rat Kidney and Liver.

Acta Histochem Cytochem 2020 Jun 29;53(3):55-60. Epub 2020 May 29.

Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.

Alogliptin is one of a new class of therapeutic agents for type 2 diabetes called dipeptidyl peptidase-4 inhibitors. Here, we used immunohistochemistry to investigate the pharmacokinetics of alogliptin at the cell and tissue levels in the rat kidney and liver. One hour after alogliptin administration, the most noticeable immunoreactivity in the kidney was a moderate-to-strong staining in proximal tubule S3 segment epithelial cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1267/ahc.19036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322161PMC

Differential Localization and Invasion of Tumor Cells in Mouse Models of Human and Murine Leukemias.

Acta Histochem Cytochem 2020 Jun 29;53(3):43-53. Epub 2020 Apr 29.

Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Leukemias are refractory hematopoietic malignancies, for which the development of new therapeutic agents requires studies using tumor-bearing mouse models. Although several organs are commonly examined in such studies to evaluate the disease course, the effectiveness of interventions and the localization of tumor cells in the affected organs are still unclear. In this study, we histologically examined the distribution of leukemia cells in several organs using two leukemic mouse models produced by the administration of two cell lines (THP-1, a human myelomonocytic leukemia, and A20, a mouse B cell leukemia/lymphoma) to severe immunodeficient mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1267/ahc.19035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322163PMC

Vitamin D and the Host-Gut Microbiome: A Brief Overview.

Acta Histochem Cytochem 2020 Jun 16;53(3):33-42. Epub 2020 Jun 16.

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.

There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords "vitamin D," "intestines," "gut microflora," "bowel inflammation". Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1267/ahc.20011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322162PMC

Crystal structures of two isostructural compounds: a second polymorph of dipotassium hydrogen citrate, KHCHO, and potassium rubidium hydrogen citrate, KRbHCHO.

Acta Crystallogr C Struct Chem 2020 Jul 30;76(Pt 7):706-715. Epub 2020 Jun 30.

Department of Chemistry, North Central College, 131 S. Loomis St., Naperville, IL 60540, USA.

The crystal structures of a new polymorph of dipotassium hydrogen citrate, 2K·HCHO, and potassium rubidium hydrogen citrate, K·Rb·HCHO, have been solved and refined using laboratory powder X-ray diffraction and optimized using density functional techniques. In the new polymorph of the dipotassium salt, KO and KO coordination polyhedra share corners and edges to form a three-dimensional framework with channels parallel to the a axis and [111]. The hydrophobic methylene groups face each other in the channels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053229620008281DOI Listing

Chiral anionic layers in tartramide spiroborate salts and variable solvation for [NR][B(TarNH)] (R = Et, Pr or Bu).

Acta Crystallogr C Struct Chem 2020 Jul 30;76(Pt 7):695-705. Epub 2020 Jun 30.

Department of Chemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, People's Republic of China.

The spiroborate anion, namely, 2,3,7,8-tetracarboxamido-1,4,6,9-tetraoxa-5λ-boraspiro[4.4]nonane, [B(TarNH)], derived from the diol L-tartramide TarNH, [CH(O)(CONH)], shows a novel self-assembly into two-dimensional (2D) layer structures in its salts with alkylammonium cations, [NR] (R = Et, Pr and Bu), and sparteinium, [HSpa], in which the cations and anions are segregated. The structures of four such salts are reported, namely, the tetrapropylazanium salt, CHN·CHBNO, the tetraethylazanium salt hydrate, CHN·CHBNO·6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053229620008384DOI Listing

Synthesis, structure and magnetism of a new ionic pentanuclear iron cluster.

Acta Crystallogr C Struct Chem 2020 Jul 29;76(Pt 7):690-694. Epub 2020 Jun 29.

College of Chemistry and Bioengineering (Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials), Guilin University of Technology, Guilin 541004, People's Republic of China.

A new ionic pentanuclear Fe cluster, namely, triethylazanium tetrakis(μ-5-amino-1,2,3,4-tetrazolido)tetrakis(μ-4-chloro-2-{[(1H-tetrazol-1-id-5-yl)imino]methyl}phenolato)di-μ-oxido-pentairon(III) acetonitrile monosolvate monohydrate, (CHN)[Fe(CHClNO)(CHN)O]·CHCN·HO, was synthesized using microvial synthesis methods and characterized by elemental analysis, FT-IR spectroscopy, single-crystal X-ray diffraction and thermogravimetric analysis. Magnetic studies reveal that the complex displays dominant antiferromagnetic intracluster interactions between the Fe ions through the μ-oxide bridges. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S205322962000861XDOI Listing

The conformational analyses of 2-amino-N-[2-(dimethylphenoxy)ethyl]propan-1-ol derivatives in different environments.

Acta Crystallogr C Struct Chem 2020 07 27;76(Pt 7):681-689. Epub 2020 Jun 27.

Pedagogical University, Institute of Biology, Podchorążych 2, 30-084 Kraków, Poland.

Four crystal structures of 2-amino-N-(dimethylphenoxyethyl)propan-1-ol derivatives, characterized by X-ray diffraction analysis, are reported. The free base (R,S)-2-amino-N-[2-(2,3-dimethylphenoxy)ethyl]propan-1-ol, CHNO, 1, crystallizes in the space group P2/n, with two independent molecules in the asymmetric unit. The hydrochloride, (S)-N-[2-(2,6-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium chloride, CHNO·Cl, 2c, crystallizes in the space group P2, with one cation and one chloride anion in the asymmetric unit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053229620008244DOI Listing
  • Page 1 of 13498