8,859 results match your criteria Acta psychiatrica Scandinavica[Journal]


Borderline patients have difficulties describing feelings; bipolar II patients describe difficult feelings. An alexithymia study.

Acta Psychiatr Scand 2020 Jun 27. Epub 2020 Jun 27.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Objective: Apparent similarities between borderline personality disorder (BPD) and bipolar II disorder (BIP-II) contribute to clinical difficulties in distinguishing between the disorders. Here, we aimed to explore how subjective Difficulties with the Identification and Description of Feelings (DIDF), a major constituent of the alexithymia construct and assessed as a part of the Toronto Alexithymia Scale (TAS), are related to relationship problems and health complaints in these groups.

Methods: Twenty-two patients with BPD; 22 patients with BIP-II; and 23 healthy controls (HC) completed TAS. Read More

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http://dx.doi.org/10.1111/acps.13204DOI Listing

Risk of psychiatric diagnoses in children and adolescents of parents with torture and war-trauma.

Acta Psychiatr Scand 2020 Jun 21. Epub 2020 Jun 21.

NCRR - National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.

Objective: Evidence point to intergenerational effects of trauma in refugee populations. This study estimates the risk of psychiatric diagnoses in children of severely traumatised refugees. The unique clinical sample consisted of refugee parents treated for torture and war-trauma, and outcomes were investigated using population-level data. Read More

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http://dx.doi.org/10.1111/acps.13203DOI Listing

When and how to use Lithium.

Acta Psychiatr Scand 2020 Jun 11. Epub 2020 Jun 11.

Professor of Psychiatry, Tufts University School of Medicine, Boston, MA, USA.

Background: Lithium is an old proven medication, but it is infrequently used in current practice. This review examines evidence for its benefits and risks, and provides clinical guidance to its use.

Methods: Narrative review. Read More

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http://dx.doi.org/10.1111/acps.13202DOI Listing

Efficacy, acceptability, and tolerability of all available treatments for insomnia in the elderly: a systematic review and network meta-analysis.

Acta Psychiatr Scand 2020 Jun 10. Epub 2020 Jun 10.

Department of Psychiatry and Psychotherapy, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Objectives: Symptoms of insomnia are highly prevalent in the elderly. A significant number of pharmacological and non-pharmacological interventions exist, but, up-to-date, their comparative efficacy and safety has not been sufficiently assessed.

Methods: We integrated the randomized evidence from every available treatment for insomnia in the elderly (>65 years) by performing a network meta-analysis. Read More

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http://dx.doi.org/10.1111/acps.13201DOI Listing

Mental health and gender dysphoria - why does it matter?

Authors:
A Giraldi

Acta Psychiatr Scand 2020 Jun;141(6):483-485

Sexological Clinic, Psychiatric Center Copenhagen, Rigshospitalet & Department of Clinical Medicine, Univeristy of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/acps.13182DOI Listing

Randomized controlled trial of multi-modular motion-assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder.

Acta Psychiatr Scand 2020 Jun 3. Epub 2020 Jun 3.

Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To explore the potential efficacy of multi-modular motion-assisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment-resistant service-related PTSD.

Methods: Exploratory single-blind, randomized, parallel arm, cross-over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome.

Results: A total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. Read More

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http://dx.doi.org/10.1111/acps.13200DOI Listing

Potential language bias in systematic reviews on the use of coercion in psychiatry.

Authors:
Tilman Steinert

Acta Psychiatr Scand 2020 Jun 3. Epub 2020 Jun 3.

Clinic for Psychiatry and Psychotherapy I, Ulm University, Centers for Psychiatry Suedwuerttemberg, Ravensburg, Germany.

Gooding and colleagues (1) present an international scoping review on studies that examined measures to reduce coercion in mental health services. The topic is of high interest and they conducted a wide search in a reasonable set of databases, yielding eventually 121 empirical research papers. 65 out of these papers, more than the half, stem from countries where English is spoken as native or official language (the latter applies to countries such as India or Ghana). Read More

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http://dx.doi.org/10.1111/acps.13199DOI Listing

Evaluation of the proposed anti-N-methyl-d-aspartate receptor encephalitis clinical diagnostic criteria in psychiatric patients.

Acta Psychiatr Scand 2020 May 30. Epub 2020 May 30.

Metro South Addiction and Mental Health, Brisbane, Australia.

Objective: The gold standard for diagnosing anti-NMDAR encephalitis is demonstration of the antibody in CSF. Clinical diagnostic criteria have been proposed for when this is not available in a timely manner which is evaluated, in this study, for a psychiatric population.

Methods: This study retrospectively assessed the proposed criteria in patients presenting to psychiatric services for the first time with known anti-NMDAR antibody status. Read More

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http://dx.doi.org/10.1111/acps.13197DOI Listing

Understanding electroconvulsive therapy-related anxiety: a prospective study.

Acta Psychiatr Scand 2020 May 31. Epub 2020 May 31.

Academic Center for ECT and Neuromodulation (AcCENT), KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg, Belgium.

Aims Of Study: Although electroconvulsive therapy (ECT)-related anxiety is experienced by a significant proportion of patients, it remains understudied. Our aim was to study the course of ECT-related anxiety during ECT.

Methods: Seventy-four patients with unipolar or bipolar depression, referred for ECT, were included. Read More

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http://dx.doi.org/10.1111/acps.13198DOI Listing

Pneumonia risk: approximately one-third is due to clozapine and two-thirds is due to treatment-ressistant schizophrenia.

Acta Psychiatr Scand 2020 May 16. Epub 2020 May 16.

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA.

A recent umbrella review suggested that pneumonia is the most robust of the life-threatening medical events associated with antipsychotic use. More importantly, the literature suggests that clozapine appears to be more strongly associated with pneumonia than are other antipsychotics. However, clozapine is mainly prescribed in patients with treatment-resistant schizophrenia (TRS); therefore, the risk of pneumonia in clozapine patients is likely to be the result of the combined effects of TRS and clozapine. Read More

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http://dx.doi.org/10.1111/acps.13184DOI Listing

Comparison of the efficacy of electroconvulsive therapy (ECT) plus agomelatine to ECT plus placebo in treatment-resistant depression.

Acta Psychiatr Scand 2020 May 15. Epub 2020 May 15.

Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.

Objective: Electroconvulsive therapy (ECT) is commonly used to treat patients with treatment-resistant depression. We aimed to investigate whether combining an antidepressant agent with ECT might enhance therapeutic efficacy and prevent early relapse.

Method: During the acute ECT phase, patients (N = 97) with treatment-resistant depression were randomized to receive ECT plus agomelatine 50 mg/day (n = 48) or ECT plus placebo (n = 49). Read More

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http://dx.doi.org/10.1111/acps.13183DOI Listing

Increased maternal new-onset psychiatric disorders after delivering a child with a major anomaly: a cohort study.

Acta Psychiatr Scand 2020 May 14. Epub 2020 May 14.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: The birth of a child with a major congenital anomaly may create chronic caregiving stress for mothers, yet little is known about their psychiatric outcomes.

Aims: To evaluate the association of the birth of a child with a major congenital anomaly with subsequent maternal psychiatric risk.

Methods: This Danish nationwide cohort study included mothers who gave birth to an infant with a major congenital anomaly (n = 19 220) between 1997 and 2015. Read More

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http://dx.doi.org/10.1111/acps.13181DOI Listing

Cognitive and Emotional Empathy in Individuals at Clinical High Risk of Psychosis.

Acta Psychiatr Scand 2020 Apr 27. Epub 2020 Apr 27.

Department of Psychiatry and Psychotherapy, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Background: Impairments of social cognition are considered core features of schizophrenia and are established predictors of social functioning. However, affective aspects of social cognition including empathy have far less been studied than its cognitive dimensions. The role of empathy in the development of schizophrenia remains largely elusive. Read More

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http://dx.doi.org/10.1111/acps.13178DOI Listing

Association between Preeclampsia and Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: An Intergenerational Analysis.

Acta Psychiatr Scand 2020 Apr 26. Epub 2020 Apr 26.

INFANT Research Centre, Cork, Ireland.

Using a large Swedish-based registry cohort, we estimated that preeclampsia is associated with a 25% increase in the likelihood of autism spectrum disorder (ASD), and a 15% increase in the likelihood of attention deficit hyperactivity disorder (ADHD) (n=2,842,230 and 2,047,619 respectively)(1, 2). Evidence suggests that certain non-communicable diseases may have an effect across several generations(3, 4). However, whether there is any intergenerational link between preeclampsia exposure and ASD or ADHD outcome in the child is unknown. Read More

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http://dx.doi.org/10.1111/acps.13180DOI Listing

Evening chronotype, disordered eating behavior, and poor dietary habits in bipolar disorder.

Acta Psychiatr Scand 2020 Apr 26. Epub 2020 Apr 26.

Lindner Center of HOPE, Mason, OH, USA.

Objective: Our aim was to evaluate the relationship between evening chronotype, a proxy marker of circadian system dysfunction, and disordered eating behavior and poor dietary habits in individuals with bipolar disorder (BD).

Methods: In this cross-sectional study, we evaluated 783 adults with BD. Chronotype was determined using item 5 from the reduced Morningness-Eveningness Questionnaire. Read More

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http://dx.doi.org/10.1111/acps.13179DOI Listing
April 2020
5.605 Impact Factor

Lifestyle behaviours during the COVID-19 - time to connect.

Acta Psychiatr Scand 2020 05;141(5):399-400

Instituto de Comunicação e Informação Cientifica e Tecnológica em Saúde / Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1111/acps.13177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264786PMC

Optimizing psychiatric care during the COVID-19 pandemic.

Acta Psychiatr Scand 2020 Apr 22. Epub 2020 Apr 22.

Department of Clinical Medicine, Aarhus University, Denmark.

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http://dx.doi.org/10.1111/acps.13176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264740PMC

Electroconvulsive therapy: we are hesitant to use the most effective treatment for severe depression.

Acta Psychiatr Scand 2020 Apr;141(4):301-303

Department of Biomedical Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1111/acps.13171DOI Listing

The gut microbiome and inflammation in obsessive-compulsive disorder patients compared to age- and sex-matched controls: a pilot study.

Acta Psychiatr Scand 2020 Apr 20. Epub 2020 Apr 20.

MacAnxiety Research Centre, Hamilton, ON, Canada.

Objective: To compare the gut microbiome profile (by way of taxon analysis and indices of β- and α-diversity) and inflammatory markers (C-reactive protein [CRP], interleukin-6[IL-6] and tumour necrosis factor-α [TNF-α]) of obsessive-compulsive disorder (OCD) outpatients and non-psychiatric community controls.

Methods: We collected morning stool and blood samples from 21 non-depressed, medication-free OCD patients and 22 age- and sex-matched non-psychiatric community controls. Microbiota analysis was performed using Illumina sequencing of the V3 region of 16S rRNA; serum CRP samples were analysed using immunoturbidimetry and plasma IL-6/TNF-α were examined by high-sensitivity ELISA. Read More

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http://dx.doi.org/10.1111/acps.13175DOI Listing
April 2020
5.605 Impact Factor

Reporting trigger factors for (hypo)manic episodes in bipolar disorder: association with personality and prognosis.

Acta Psychiatr Scand 2020 Jun 7;141(6):534-540. Epub 2020 May 7.

Department of Psychiatry and Neurochemistry at Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Objective: To investigate external factors that trigger manic and hypomanic relapses and how this is associated with personality and clinical outcome measured as number of affective episodes over a 7-year period.

Method: This is a prospective cohort study of 204 meticulously characterized Swedish bipolar disorder patients. Personality was evaluated at baseline using the Swedish universities Scales of Personality in 170 patients, and 90 patients were followed up after approximately 7 years in order to evaluate clinical outcomes. Read More

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http://dx.doi.org/10.1111/acps.13174DOI Listing

Educational needs and psychoeducation interventions in clozapine users: a narrative review.

Authors:
H Verdoux C Quiles

Acta Psychiatr Scand 2020 Apr 8. Epub 2020 Apr 8.

Centre Hospitalier Charles Perrens, Bordeaux, France.

Objective: Increasing users' knowledge about the expected benefits and risks of clozapine may contribute to the initiation and maintenance of clozapine in persons with treatment-resistant schizophrenia (TRS). The objective was to identify the educational needs of clozapine users and the interventions aimed at addressing these needs.

Method: We systematically searched multiple electronic databases for articles: (i) exploring educational needs of clozapine users and of their relatives; and (ii) reporting educational interventions aimed at addressing these needs. Read More

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http://dx.doi.org/10.1111/acps.13172DOI Listing

Blood biomarker levels of methylation capacity in autism spectrum disorder: a systematic review and meta-analysis.

Acta Psychiatr Scand 2020 Jun 6;141(6):492-509. Epub 2020 Apr 6.

Department of Child and Adolescent Health, School of Public Health, Xinxiang Medical University, Xinxiang, Henan, China.

Objective: To compare the peripheral blood levels of methionine (Met), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and the SAM/SAH ratio (the most core and predictive indices of cellular methylation ability) between patients with autism spectrum disorder (ASD) and control subjects.

Methods: PubMed, Embase, PsycINFO, Web of Science, and Cochrane Library were searched from inception to August 2, 2019, without language restriction. The random-effects model was used to summarize effect sizes. Read More

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http://dx.doi.org/10.1111/acps.13170DOI Listing

Identifying the cognitive underpinnings of voice-hearing by comparing never, past and current voice-hearers.

Acta Psychiatr Scand 2020 Jun 23;141(6):553-562. Epub 2020 Mar 23.

Faculty of Health, Arts & Design, Centre for Mental Health, Swinburne University of Technology, Melbourne, Vic., Australia.

Objective: The current study aimed to compare specific cognitive profiles corresponding to auditory verbal hallucinations (AVH) status and elucidate which pattern of cognitive deficits may predict voice-hearing status.

Method: Clinical participants with schizophrenia spectrum disorders were partitioned into: (i) current voice-hearers (n = 46), (ii) past voice-hearers (n = 37) and (iii) never voice-hearers (n = 40), and compared with 319 non-clinical controls. Cognitive assessment employed the MATRICS Consensus Cognitive Battery (MCCB), supplemented by the Delis-Kaplan Executive Function System (D-KEFS) Colour-Word Interference Test (Stroop) as a robust measure of executive function. Read More

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http://dx.doi.org/10.1111/acps.13169DOI Listing

Paradigms lost, gained and retained.

Authors:
G Parker

Acta Psychiatr Scand 2020 Jun 20;141(6):565-566. Epub 2020 Mar 20.

School of Psychiatry, University of NSW, Kensington, NSW, Australia.

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http://dx.doi.org/10.1111/acps.13168DOI Listing

Clozapine: a fine balance.

Authors:
D Siskind J Nielsen

Acta Psychiatr Scand 2020 Mar;141(3):175-177

Mental Health Centre Glostrup, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/acps.13159DOI Listing

Validity of the personality disorder diagnosis in the Swedish National Patient Register.

Acta Psychiatr Scand 2020 May 20;141(5):432-438. Epub 2020 Mar 20.

Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.

Aims: The Swedish National Patient Register (NPR) is an exceptional source of information in clinical epidemiological research. The register is, however, not validated for the diagnosis of personality disorder (PD). We therefore assessed its validity in this patient group, and the group with emotionally unstable PD (EUPD)/borderline personality disorder (BPD). Read More

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http://dx.doi.org/10.1111/acps.13166DOI Listing

Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls.

Acta Psychiatr Scand 2020 May 18;141(5):452-464. Epub 2020 Mar 18.

NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Objective: Apathy is a central predictor of a poor functional outcome in schizophrenia. Schizophrenia polygenic risk scores (PRSs) are used to detect genetic associations to key clinical phenotypes in schizophrenia. We explored the associations between schizophrenia PRS and apathy levels in schizophrenia spectrum disorders (n = 281) and matched healthy controls (n = 298), and further how schizophrenia PRS contributed in predicting apathy when added to premorbid and clinical factors in the patient sample. Read More

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http://dx.doi.org/10.1111/acps.13167DOI Listing

Can network analysis shed light on predictors of lithium response in bipolar I disorder?

Acta Psychiatr Scand 2020 Jun 15;141(6):522-533. Epub 2020 Mar 15.

Université Paris Diderot and INSERM UMRS1144, Paris, France.

Objective: To undertake a large-scale clinical study of predictors of lithium (Li) response in bipolar I disorder (BD-I) and apply contemporary multivariate approaches to account for inter-relationships between putative predictors.

Methods: We used network analysis to estimate the number and strength of connections between potential predictors of good Li response (measured by a new scoring algorithm for the Retrospective Assessment of Response to Lithium Scale) in 900 individuals with BD-I recruited to the Consortium of Lithium Genetics.

Results: After accounting for co-associations between potential predictors, the most important factors associated with the good Li response phenotype were panic disorder, manic predominant polarity, manic first episode, age at onset between 15-32 years and family history of BD. Read More

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http://dx.doi.org/10.1111/acps.13163DOI Listing

Association between preeclampsia and attention-deficit hyperactivity disorder: a population-based and sibling-matched cohort study.

Acta Psychiatr Scand 2020 Feb 13. Epub 2020 Feb 13.

INFANT Research Centre, Cork, Ireland.

Objective: To examine the association between preeclampsia and attention-deficit hyperactivity disorder (ADHD), using a large Swedish-based registry cohort.

Methods: This study comprised 2 047 619 children, with 114 934 (5.6%) cases of ADHD. Read More

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http://dx.doi.org/10.1111/acps.13162DOI Listing
February 2020

Traumatic experiences, ICD-11 PTSD, ICD-11 complex PTSD, and the overlap with ICD-10 diagnoses.

Acta Psychiatr Scand 2020 May 29;141(5):421-431. Epub 2020 Feb 29.

Psychiatric Research Unit, Region Zealand, Slagelse, Denmark.

Objectives: This study investigated the frequency of traumatic experiences, prevalence rates of ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD), and overlap with ICD-10 classified disorders in outpatient psychiatry.

Method: Overall, 165 Danish psychiatric outpatients answered the International Trauma Questionnaire, the Life Event Checklist, and the World Health Organization Well-being Index. ICD-10 diagnoses were extracted from the hospital record. Read More

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http://dx.doi.org/10.1111/acps.13161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317379PMC

Psychiatry needs a new paradigm.

Authors:
T Steinert

Acta Psychiatr Scand 2020 Jun 29;141(6):563-564. Epub 2020 Feb 29.

Clinic for Psychiatry and Psychotherapy I, Centers for Psychiatry Suedwuerttemberg, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1111/acps.13160DOI Listing

Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness.

Acta Psychiatr Scand 2020 May 21;141(5):465-475. Epub 2020 Feb 21.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.

Objective: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.

Methods: The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Read More

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http://dx.doi.org/10.1111/acps.13158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318228PMC

Diagnostic tests and treatment procedures performed prior to cardiovascular death in individuals with severe mental illness.

Acta Psychiatr Scand 2020 May 29;141(5):439-451. Epub 2020 Feb 29.

Center for Clinical Documentation and Evaluation (SKDE), Tromsø, Norway.

Objective: To examine whether severe mental illnesses (i.e., schizophrenia or bipolar disorder) affected diagnostic testing and treatment for cardiovascular diseases in primary and specialized health care. Read More

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http://dx.doi.org/10.1111/acps.13157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317477PMC

Multivariate classification of earthquake survivors with post-traumatic stress disorder based on large-scale brain networks.

Acta Psychiatr Scand 2020 Mar 7;141(3):285-298. Epub 2020 Feb 7.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Objective: The identification of post-traumatic stress disorder (PTSD) among natural disaster survivors is remarkably challenging, and there are no reliable objective signatures that can be used to assist clinical diagnosis and optimize treatment. The current study aimed to establish a neurobiological signature of PTSD from the connectivity of large-scale brain networks and clarify the brain network mechanisms of PTSD.

Methods: We examined fifty-seven unmedicated survivors with chronic PTSD and 59 matched trauma-exposed healthy controls (TEHCs) using resting-state functional magnetic resonance imaging (rs-fMRI). Read More

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http://dx.doi.org/10.1111/acps.13150DOI Listing

Thyroid hormone treatment in the management of treatment-resistant unipolar depression: a systematic review and meta-analysis.

Acta Psychiatr Scand 2020 Apr 12;141(4):316-326. Epub 2020 Feb 12.

Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.

Background: Treatment with thyroid hormones is occasionally used in the management of treatment-resistant depression. However, the evidence supporting this treatment is not fully established. The aim of this study was to systematically review the literature on the effect of adjunctive thyroid hormone in the management of treatment-resistant unipolar depression and to provide a pooled estimate of its efficacy. Read More

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http://dx.doi.org/10.1111/acps.13154DOI Listing

Effect of age on the relative efficacy of clozapine in schizophrenia.

Acta Psychiatr Scand 2020 Jan 24. Epub 2020 Jan 24.

Institute for Mental Health, University of Birmingham, Birmingham, UK.

Objective: Early treatment of schizophrenia improves outcomes. Clozapine appears to have unique benefit when other antipsychotic medication has failed. This systematic review and meta-analysis aims to assess clozapine's superiority over alternative antipsychotic medication and examine whether earlier use is associated with additional benefit. Read More

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http://dx.doi.org/10.1111/acps.13156DOI Listing
January 2020

Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster.

Acta Psychiatr Scand 2020 May;141(5):476-478

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1111/acps.13155DOI Listing

Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta-analyses.

Acta Psychiatr Scand 2020 Jun 11;141(6):510-521. Epub 2020 Feb 11.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.

Objectives: To assess whether bipolar disorder (BD) increases the rate of dementia and whether lithium is related to a lower risk of dementia in BD.

Methods: A total of 10 studies (6859 BD; 487 966 controls) were included in the meta-analysis to test whether BD is a risk factor for dementia. In addition, five studies (6483 lithium; 43 496 non-lithium) were included in the meta-analysis about the potential protective effect of lithium in BD. Read More

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http://dx.doi.org/10.1111/acps.13153DOI Listing

Trajectory of cognitive functions in bipolar disorder: for better or worse?

Acta Psychiatr Scand 2020 02;141(2):95-97

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/acps.13144DOI Listing
February 2020

Aksel Brockhusen Bertelsen *25 July 1936 †9 October 2019.

Acta Psychiatr Scand 2020 02;141(2):172

Psychiatric Centre Copenhagen, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/acps.13135DOI Listing
February 2020

Preventing and reducing 'coercion' in mental health services: an international scoping review of English-language studies.

Acta Psychiatr Scand 2020 Jan 17. Epub 2020 Jan 17.

University of Melbourne, Parkville, Vic, Australia.

This article discusses initiatives aimed at preventing and reducing 'coercive practices' in mental health and community settings worldwide, including in hospitals in high-income countries, and in family homes and rural communities in low- and middle-income countries. The article provides a scoping review of the current state of English-language empirical research. It identifies several promising opportunities for improving responses that promote support based on individuals' rights, will and preferences. Read More

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http://dx.doi.org/10.1111/acps.13152DOI Listing
January 2020

Digital navigators to implement smartphone and digital tools in care.

Acta Psychiatr Scand 2020 Apr 26;141(4):350-355. Epub 2020 Jan 26.

Division of Digital Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

While smartphone apps and other digital health tools have the clear potential to increase both quality of and access to care, actual successful implementation remains limited. Challenges often encountered in seeking to use apps in care include selecting safe/effective tools, spending clinical time troubleshooting technology instead of discussing health matters, and lack of time to check and review constant streams of data these digital tools can produce. In this 'From Research to Clinical Practice' piece, we focus on how a new care team member, the digital navigator, can help overcome these barriers through conducting evidence-based app evaluation to help in selecting the right apps, troubleshooting technology outside of visits to improve the therapeutic alliance during, and finally summarizing digital data to facilitate clinical care that focus on actionable data. Read More

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http://dx.doi.org/10.1111/acps.13149DOI Listing

Actigraphic patterns, impulsivity and mood instability in bipolar disorder, borderline personality disorder and healthy controls.

Acta Psychiatr Scand 2020 Apr 20;141(4):374-384. Epub 2020 Jan 20.

Department of Psychiatry, University of Oxford, Oxford, UK.

Objectives: To differentiate the relation between the structure and timing of rest-activity patterns and symptoms of impulsivity and mood instability in bipolar disorder (BD), borderline personality disorder (BPD) and healthy controls (HC).

Methods: Eighty-seven participants (31 BD, 21 BPD and 35 HC) underwent actigraph monitoring for 28 days as part of the Automated Monitoring of Symptom Severity (AMoSS) study. Impulsivity was assessed at study entry using the BIS-11. Read More

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http://dx.doi.org/10.1111/acps.13148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216871PMC

Age at migration and the risk of psychotic disorders: a systematic review and meta-analysis.

Acta Psychiatr Scand 2020 May 20;141(5):410-420. Epub 2020 Jan 20.

Department of Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada.

Objective: To conduct a systematic review and meta-analysis of the existing evidence on the association between age at migration and the risk of psychotic disorders.

Methods: Observational studies were eligible for inclusion if they presented data on the association between age at migration and the risk of psychotic disorders among first-generation migrant groups. We used two random effects meta-analyses to pool effect estimates for each stratum of age at migration relative to (i) a native-born reference category and (ii) the youngest age stratum (0 to 2 years). Read More

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http://dx.doi.org/10.1111/acps.13147DOI Listing

Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study.

Acta Psychiatr Scand 2020 Apr 9;141(4):327-339. Epub 2020 Feb 9.

Harvard Medical School, Boston, MA, USA.

Objective: Anxiety disorders (AD) are known for its comorbidity and negative impact on the course of adult bipolar disorder (BD). However, there is limited research on AD comorbidity in pediatric BD (PBD). Here, we aimed to conduct a meta-analysis and meta-regression study about the comorbidity and covariates of AD and PBD. Read More

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http://dx.doi.org/10.1111/acps.13146DOI Listing

No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review.

Acta Psychiatr Scand 2020 May 17;141(5):401-409. Epub 2020 Jan 17.

Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.

Background: In fixed-dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side-effects permit provides additional benefits is unknown.

Methods: We did a systematic review of placebo-controlled randomized trials that examined selective serotonin reuptake inhibitors (SSRIs), venlafaxine or mirtazapine in the acute treatment of major depression. Read More

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http://dx.doi.org/10.1111/acps.13145DOI Listing

Concordance between health administrative data and survey-derived diagnoses for mood and anxiety disorders.

Acta Psychiatr Scand 2020 Apr 26;141(4):385-395. Epub 2020 Jan 26.

Department of Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada.

Objective: To assess whether estimates of survey structured interview diagnoses of mood and anxiety disorders were concordant with diagnoses of these disorders obtained from health administrative data.

Methods: All Ontario respondents to the 2012 Canadian Community Health Survey-Mental Health (CCHS-MH) were linked to health administrative databases at ICES (formerly known as the Institute for Clinical Evaluative Sciences). Survey structured interview diagnoses were compared with health administrative data diagnoses obtained using a standardized algorithm. Read More

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http://dx.doi.org/10.1111/acps.13143DOI Listing