1,770 results match your criteria Acta pharmaceutica Hungarica[Journal]


[Formulation possibilities of self-emulsifying drug deliv- ery systems, microemulsions and nanoemulsions.]

Acta Pharm Hung 2017 ;87(1):27-34

Objective The aim of this review is to introduce the self-emulsifying drug delivery systems which can be used to improved the bioavailability of poorly water soluble drug substances. Methods The review summarizes the most prominent results of the lipid based medicinal preparations, such as microemulsions and nanoemulsions developed in the last two decades. Results The analysis of the references details the lipid based formulation classification systems, the most common excipients, the quality attributes depending on the ingredients, as well as the differences in the characteristics of micro- and nanoemulsions. Read More

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April 2018
2 Reads

[Polyphenolic compounds analysis and antioxidant activity in fruits of Prunus spinosa L.]

Acta Pharm Hung 2017 ;87(1):19-25

Introduction: Prunus spinosa L. (blackthorn, sloe) is a com- mon species in the wild flora of Europe. Marmalade, syrup, and alcoholic beverages have been prepared from fruits. Read More

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April 2018
2 Reads

[Measuring anxiety with behavior analysis software and comparing human observations with EthoVision XT in the elevated plus maze paradigm.]

Acta Pharm Hung 2017 ;87(1):13-18

Introduction: The reproduction of anxiety in laboratory animals is a renewing problem whenever a new drug is to be tested for its anxiolytic effect. Some gold-standard tests, such as the elevated plus maze test, are always considered to be used as reference. However, many controversial results for different anxiolytics were reported in elevated plus maze test. Read More

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In vitro skin models in the optimization of skin formulations.

Acta Pharm Hung 2017 ;87(1):3-12

Background: Transdermal drug delivery is assumed to have a growing importance in drug development recently, thus it is crucial to optimize the penetration properties of drug into through the skin. Most of the current developments rely on the use of appropriate ex vivo animal or artificial models. However, the limited availability of human skin and the increasing restrictions in connection with animal testing encouraged the searchfor suitable artificial skin models. Read More

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April 2018
4 Reads

[Phytopharmacological review of bathurst burr (Xanthium spinosum L.)].

Acta Pharm Hung 2016 ;86(1):35-40

Bathurst burr (Xanthium spinosum L.) is an invasive species that is also known as a medicinal plant. Our goal is to make known the plant and its therapeutic effects in larger scale. Read More

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July 2016
1 Read

[Bisphosphonate use and related pharmaceutical issues II].

Acta Pharm Hung 2016 ;86(1):23-34

Unlabelled: Bisphosphonates have basic role in decreasing progression of malignant bone processes as well as in the prevention and therapy of osteoporosis. Use of bisphosphonates is common in Hungary since 20 years. In the past decade their reimbursement has been changed several times, the use of generics decreased the price of bisphosphonates. Read More

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July 2016
1 Read

[Therapeutic practice of bisphosphonate use and related pharmaceutical issues I].

Acta Pharm Hung 2016 ;86(1):13-22

The therapeutic use of Bisphosphonates was common in Hungary for the past two and a half decades. The main clinical application of Bisphosphonates is the therapy of osteoporosis and bone manifestations of malignant diseases. Patients' quality of life depends on the prevalence of the typical fragility fractures and their complications. Read More

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[Mass spectrometry: past and present].

Acta Pharm Hung 2016 ;86(1):3-11

Mass spectrometry is a highly sensitive high-throughput instrumental analytical technique. It is used to determine the molecular mass, but also gives information on molecular structure amd is used for quantitation as well. Although it was developed over 100 years ago, it continues to evolve, both with respect to figures of merit (like sensitivity) and with respect to applications in various novel fields of science and technology. Read More

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July 2016
3 Reads

Examination of drug safety control during the dispensing of medicines containing metformin. First results of a questionnaire survey.

Acta Pharm Hung 2016;86(2):68-72

The responsibility of pharmacists as medical experts is giving as broad information to their patients as possible to avoid the medicational problem that is endangering both the patient and the efficacy of the drug-treatment. In most cases, the medication error could be avoided by proper attention and co-operation with the patients and their doctors. We need to determine those factors, which have to be eliminated to decrease the side-effects and interactions; consequently to improve the patients' adherence with the therapy. Read More

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June 2018
3 Reads

Application of Mass Spectrometry in Proteomics.

Acta Pharm Hung 2016;86(2):61-67

Mass spectrometry is a high sensitivity, highly selective, high throughput analytical technique. It is well suited to characterize polar, high mass molecules. It is one of the prime analytical techniques to study proteins, to determine their molecular mass, their amino acid sequence and their post-translational modifications. Read More

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June 2018
1 Read

Medical application possibilities of nano- and microfibrous systems.

Acta Pharm Hung 2016;86(2):53-59

The nano- and micro fibrous systems in the textile- and plastics industry have already been used, although the opportunity for using them as medical devices has only come in recent years into view. Since then in medical sciences they have shown promise in different therapeutic purposes. The manuscript summarizes the opportunities for medical use of the nano- and micro fibrous systems. Read More

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Formulation aspects of nanopharmaceuticals and nanotechnology I Introduction, biopharmaceutical aspects.

Acta Pharm Hung 2016;86(2):43-52

Active pharmaceutical ingredients may have unique properties when applied as nanoparticles or in nanostructured carrier systems due to the size and shape, as well as to the high surface to volume ratio. Therefore nanopharmaceuticals are surrounded by huge expectations on the part of nanomedicine and today nanotechnology is crucial for the development of pharmaceutical products. Nanopharmaceuticals have several benefits such as improved dissolution and bioavailability, targeted drug delivery, and they allow the introduction of nanotheranos tics. Read More

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June 2018
1 Read

Safety risks of over-the-counter (OTC) drugs and their management.

Acta Pharm Hung 2016;86(4):151-159

The vast majority of Hungarian patients have self-diagnosed and treated themselves with over the counter medications (OTC) without any medical supervision. Patients typically consider these medications safe and easily accessible without any major potential of adverse reactions. Although, pharmaceuticals must fulfil strict criteria to gain OTC status, they still carry potential risks and safety concerns, such as misuse, abuse or interaction with other drugs or food. Read More

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Analytical Aspects of Biopharmaceuticals and their Study by Mass Spectrometry.

Acta Pharm Hung 2016;86(4):141-150

The use of biopharmaceuticals has increased significantly over the past two decades. Many original biological drugs were registered, that are mainly protein-based pruducts, produced by a biotechological method. Since biologics are heterogeneous mixtures of complex macromolecules, their characterization is an extremely complicated task. Read More

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July 2018
13 Reads

Pharaceutical chemical characterization of ezetimibe.

Acta Pharm Hung 2016;86(4):133-139

Ezetimibe belongs to a new class of lipid-lowering agents that selectively inhibit the intestinal absorption of cholesterol and related plant sterols. The molecular target of ezetimibe is the sterol transporter, Niemann-Pick C1-Like 1 (NPC1L1), which is responsible for the intestinal uptake of cholesterol and phytosterols. Its action is localized at the brush border of the small intestine where it inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. Read More

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July 2018
1 Read

[Pharmaceutical counseling of non-conventional dosage forms concerning the health-literacy and the patient adherence in public medication dispensing -Questionnaire surveys in Hungarian community pharmacies.]

Authors:
O Somogyi R Zelko

Acta Pharm Hung 2016;86(3):113-127

Although the non-conventional dosage forms (e.g. modified release per oral systems or transdermal patches) have more significant advantages than other conventional dosage forms, the pa- tients have to apply them correctly in their home medicine using to reach the effective and safe therapy. Read More

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April 2018
2 Reads

[Formulation and special investigations of innovative intraoral solid dosage forms.]

Acta Pharm Hung 2016;86(3):99-111

During our work, we summarized the types of solid dosage forms which were in the focus of attention in the last years because of their innovative pharmaceutical technology solution and simple use. The biopharmaceutics of solid dosage forms for intraoral use and the advantages of the use of these dosages forms were presented in general. However, these dosage forms cannot always be prepared with conventional pharmaceutical processes, therefore the special pharmaceutical solutions which can be applied for their preparation were presented. Read More

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[The pharmaceutical chemistry of azole antifungals.]

Acta Pharm Hung 2016;86(3):85-98

Azole antifungals are a group of compounds that play essential rule in the treatment of surface and deep mycoses. They can be used externally to treat fungal infections of skin, mucous membranes and external genitalia but they are also suitable for oral treatment of systemic mycoses. Structurally they are classified into two groups: imidazoles and triazoles. Read More

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April 2018
1 Read

[Formulation of new generation drug delivery system for dry powder inhalation.]

Acta Pharm Hung 2016;86(3):75-83

Based on the formulation method the dry powder inhalers (DPIs) can be divided in too types: carrier-based and carrier-free drug delivery systems. The newest researches report about several high potency carrier-free formulations, where the active ingredient and the excipients are together formulated to the DPI form. However, in Hungary the commercially available DPIs are carrier-based (e. Read More

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[Introduction of Functional Foods--Types, Manufacturing Methods and Quality Assurance].

Acta Pharm Hung 2015 ;85(3):97-110

Because of the beneficial effects to health functional foods are important elements of health promotion. The positive effect of the functional components should be based on scientific evidence-based. In addition to the traditional food processing technology new technologies have appeared, e. Read More

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January 2016
2 Reads

[Pharmacognosy study of Verbascum species].

Acta Pharm Hung 2015 ;85(3):89-95

The mullein (Verbascum phlomoides L., V thapsus L., V. Read More

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January 2016
81 Reads

[The effect of generic price competition on drug consumption and health insurance pharmaceutical expenditures in Hungary].

Acta Pharm Hung 2015 ;85(3):83-8

Aim: The aim of our study was to analyze the Hungarian montelukast sodium drug market. We examined the effect of the appearance of generic drugs on the price and turnover of the brand-name drug, Singulair.

Data And Methods: Data derived from the nationwide pharmaceutical database of Hungarian National Health Insurance Fund Administration (2007-2014). Read More

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January 2016
11 Reads

[Titanate nanotubes in the therapy].

Acta Pharm Hung 2015 ;85(2):71-9

The demand for revealing the medical advantages offered by nanotechnology is increasing more and more. Titanate nanotubes deserve consideration in many aspects. Their production is easy, cost-effective and environmentally friendly. Read More

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October 2015
1 Read

[Pharmaceutical chemistry of drug-initiated photosensitivity].

Acta Pharm Hung 2015 ;85(2):51-70

The photosensitivity originated from drugs is a common problem in medical and pharmaceutical practice. It is of prominent importance in drug development and in regulatory issues. The photosensitizer effect of drug substances is determined by their chemical structures, and it mainly originates from aromatic chromophore systems and photo-dissociable bonds forming free radicals. Read More

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October 2015
2 Reads

[Theory and practice of electrospray crystallization in particle size reduction].

Acta Pharm Hung 2015 ;85(2):43-50

Nowdays, one of the most challenges for the researchers is the formulation of poorly water soluble drugs. Reduction of particle size of active agents to submicron range could result in a faster dissolution rate and higher bioavailability. Integration as crystallization process is an often used particle size decreasing technique. Read More

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October 2015
8 Reads

[Occurence of diarylheptanoids in Corylus species native to Hungary].

Acta Pharm Hung 2015 ;85(1):29-38

Since the last decade naturally occurring diarylheptanoids have been in the focus of scientific interest due to their various. beneficial biological effects. Besides the outstanding importance of the curcuminoids isolated from members of the Curcuma genus (Zingiberaceae), several different diarylheptanoids identified in Alnus species (Betulaceae) have been proved to possess notable pharmacological effects. Read More

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August 2015
3 Reads

[Investigation of permeability of intranasal formulations using Side-Bi-Side horizontal diffusion cell].

Acta Pharm Hung 2015 ;85(1):19-28

Nowadays the nasal route has received a great attention as a reliable administration for the systemic administration. In the Department of Pharmaceutical Technology, University of Szeged, the main research work is the design and development of innovative nasal formulations, which can open new possibilities for some well-known agents and may also help some drug-candidates delivery problems. The aim of this work was to present some reliable models for investigation of permeability, such as Spectra/Por Dialisys Membran, ZelluTrans/Roth Mini Dialyzer, μFLUX diffusion Cell, Navicyte Vertical and Horizontal Diffusion Chamber System and In-line Cell. Read More

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August 2015
11 Reads

[The pharmacotherapy of obesity].

Acta Pharm Hung 2015 ;85(1):3-17

Obesity is considered the most concerning and blatantly visible--yet most neglected--public health problem by the WHO. The steadily increasing number of overweight and obese people has reached 2.3 billion and 700 million worldwide, respectively. Read More

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August 2015
1 Read

[Development of new magistral method for the preparation of artificial tears].

Acta Pharm Hung 2015 ;85(4):139-43

Nowadays, large part of the population in Hungary is affected by the dry eye disease or symptom. Most of these magistral pharmaceuticals (FoNo VI) compared to the industrial products have disadvantages. They are not compatible with contact lenses, because of the preservatives and after opening they can be used only for seven days. Read More

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April 2016
40 Reads

[Development possibilities of hormone-containing implants for gynecological applications: A review].

Acta Pharm Hung 2015 ;85(4):131-8

Implantable gynecological drug delivery devices are applied for contraceptive, hormone replacement purposes and for the treatments of other gynecological diseases, e.g. endometriosis. Read More

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April 2016
3 Reads

[Resveratrol in Pharmaceutical Chemistry].

Acta Pharm Hung 2015 ;85(4):123-9

Resveratrol is a polyphenol that can be found in various plants, including grapes. Wines therefore also contain this compound. The famous phenomenon, named "French paradox" is considered to be an effect of resveratrol: the regular, modest consumption of red wine causes low incidence of cardiovascular diseases. Read More

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April 2016
8 Reads

[Use of a novel polymer, the in-situ gelling mucoadhesive thiolated poly(aspartic acid) in ophthalmic drug delivery].

Acta Pharm Hung 2015 ;85(4):115-21

The bioavailability of drugs used on mucosal surfaces can be increased by the use of mucoadhesive polymers. A new type of mucoadhesive polymers is the group of thiolated polymers with thiol group containing side chains. These polymers are able to form covalent bonds (disulphide linkages) with the mucin glycoproteins. Read More

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April 2016
30 Reads

[The effect of R(+) limonene on β - adrenerg signaling: the significance of oxidative stress index].

Acta Pharm Hung 2014 ;84(3):111-9

Reactive oxygen intermediers (ROI) play a role in the signal transduction of beta-adrenergic receptors. We investigated whether an antioxidant (limonene) can reduce the beta-mimetic effect of terbutaline in beta-2-adrenergic receptor (β2-AR)-regulated smooth muscles. Tissue samples were collected from nonpregnant (trachea) and 22-day-pregnant (myometrium and cervix) rats. Read More

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July 2018
1 Read

[The effect of R(+) limonene on β-adrenergic signaling in smooth muscles: the significance of oxidative stress index].

Acta Pharm Hung 2014 ;84(3):111-9

Reactive oxygen intermediers (ROI) play a role in the signal transduction of beta-adrenergic receptors. We investigated whether an antioxidant (limonene) can reduce the beta-mimetic effect of terbutaline in beta-2-adrenergic receptor (β2-AR)-regulated smooth muscles. Tissue samples were collected from nonpregnant (trachea) and 22-day-pregnant (myometrium and cervix) rats. Read More

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January 2015
5 Reads

[Phytochemical and antimicrobial investigation of Epilobium angustifolium L].

Acta Pharm Hung 2014 ;84(3):105-10

Phytochemical studies of Epilobium angustifolii herba aimed the determination of the active ingredients; antimicrobial activity of the aqueous and ethanolic extracts against human pathogenic bacteria and fungi was also examined. Six flavonoid and 4 phytosterol fractions were identified by thin layer chromatography, while tannins were present in low concentration. It has been shown that not only the ethanolic but also the aqueous extracts had inhibitory effect on certain pathogenic microorganisms, therefore E. Read More

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January 2015
2 Reads

[Pyrido[2,3-b]pyrazines inhibiting both erlotinib-sensitive and erlotinib-resistant cell lines, and their preparation via regioselective condensation reaction].

Acta Pharm Hung 2014 ;84(3):91-104

The EGFR inhibitor erlotinib possesses high anti-tumor effect but despite the good clinical responses in most of the cases recrudescence occures. This can be attributed to a secondary, acquired mutation causing resistance to tyrosine kinase inhibitors. In our work we were looking for small-molecule inhibitors, which simultaneously affect on the proliferation of erlotinib-sensitive PC9 cells and PC9-ER erlotinib-resistant cells. Read More

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January 2015
10 Reads

[Experiences with price competition of biosimilar drugs in Hungary].

Acta Pharm Hung 2014 ;84(2):83-7

Aim: The aim of our study is to analyse the biosimilar bids of the Hungarian National Health Insurance Fund Administration in case of colony-stimulating factor and erythropoietin products.

Data And Methods: Data derived from the nationwide pharmaceutical database of Hungarian National Health Insurance Fund Administration. We analysed how the number of patients treated by colony-stimulating factor and erythropoietin products changed before (01. Read More

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October 2014
13 Reads

[Investigation of gestagenic effect of raw drone milk in rats].

Acta Pharm Hung 2014 ;84(2):77-81

Numerous honeybee products are used in traditional medicine. The best-known honeybee products are the honey, the propolis and the royal jelly. Drone milk is a relatively little-known honeybee product. Read More

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October 2014
12 Reads

[Formulation and characetization of self-microemulsifying drug delivery systems according to their cytotoxic attributes].

Acta Pharm Hung 2014 ;84(2):69-76

The aim of this study was to develop and examine novel drug delivery systems upon the cytotoxic behaviour of their tenside components. Different self-emulsifying combinations have been formulated by water dilution and oil dilution method with various previously tested tensides and co-tensides. The visual properties registered against the increment of the applied tenside component in Ternary triangular diagrams. Read More

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October 2014
2 Reads

[Use of Xanthii spinosi herba in treatment of benign prostate hypertrophia].

Acta Pharm Hung 2014 ;84(2):63-7

The aim of our study was to asses the efficacy of Xanthii spinosi herba in the treatment of rats with benign prostate hypertrophia induced under experimental conditions. Benign prostate hypertrophia (BPH) was induced by per oral (p.o. Read More

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October 2014
1 Read

[Stability testing of meloxicam-containing microcomposites for inhalation].

Acta Pharm Hung 2014 ;84(2):55-62

The formulation of inhalation agents is a major challenge for the pharmaceutical technologist. The innovative inhalation formulations mean a new area of indication for active pharmaceutical ingredients. Among pulmonary preparations, dry powder inhalers (DPIs) can ensure stability, a high payload and patient convenience. Read More

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October 2014
5 Reads

[The receptorial responsiveness method (RRM): a new possibility to estimate the concentration of pharmacologic agonists at their receptors].

Acta Pharm Hung 2014 ;84(1):38-52

Cardiovascular disease is the biggest challenge in terms of life expectancy in developed countries. Adenosine contributes to the adaptation of the heart to ischemia and hypoxia, because adenosine, in addition to its metabolite role in the nucleic acid metabolism, is the endogenous agonist of the ubiquitous adenosine receptor family. Adenosine receptor activation is beneficial in most cases, it improves the balance between energy supply and consumption, reduces injury caused by stressors and inhibits the unfavorable tissue remodeling. Read More

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June 2014
5 Reads

[Thyroid hormones and their precursors. II. Species-specific properties].

Acta Pharm Hung 2014 ;84(1):21-37

This paper surveys the species-specific physico-chemical parameters (basicity and lipophilicity) and related biological functions of thyroid hormones (thyroxine, liothyronine and reverse liothyronine) and their biological precursors (tyrosine, monoiodotyrosine and diiodotyrosine). The protonation macroconstants were determined by 1H NMR-pH titrations while the microconstants were determined by a multimodal spectroscopic-deductive methodology using auxiliary derivatives of reduced complexity. Our results show that the different number and/or position of iodine are the key factors to influence the phenolate basicity. Read More

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[New facts about the molecular background of isovanilline-type sweeteners].

Acta Pharm Hung 2014 ;84(1):15-9

As a continuation of our studies on the relationship between structure and sweet taste of isovanilline-type sweeteners, (3-hydroxy-4-methoxy)benzyl-benzoate (17) and -salicylate (17c), analogues of dihydrochalcone-type sweetener analogues of (+)-phyllodulcin [(+)-5] and CH-401 (14c) have been synthesized. Surprisingly, 17c has been found to be tastless, while 17e was slightly sweet. These observations could be explained by the current hypothesis on the receptor model for isovanilline-type sweet derivatives. Read More

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[Investigation of the recrystallization of trehalose as a good glass-former excipient].

Acta Pharm Hung 2014 ;84(1):7-14

An amorphous form of trehalose is easy to prepare by using a solvent method. The recrystallization kinetics can be followed well, which is important because of the occurrence of polymorphic forms of trehalose. This is especially significant in the case of dry powder inhalers. Read More

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June 2014
3 Reads

[Dr. Laszlovszky József (1923-2014)].

Authors:
Béla Noszál

Acta Pharm Hung 2014 ;84(1):5-6

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June 2014
1 Read

[Dr. Tóth Klára (1930-2013)].

Authors:
Béla Noszál

Acta Pharm Hung 2014 ;84(1):3-4

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June 2014
3 Reads

[Application of Kohonen Self-Organizing Feature Maps in QSAR of human ADMET and kinase data sets].

Acta Pharm Hung 2013 ;83(4):143-8

Vichem Chemie Kutató Kft., Herman Ottó utca 15. 1022 Budapest.

QSAR predictions have been proven very useful in a large number of studies for drug design, such as kinase inhibitor design as targets for cancer therapy, however the overall predictability often remains unsatisfactory. To improve predictability of ADMET features and kinase inhibitory data, we present a new method using Kohonen's Self-Organizing Feature Map (SOFM) to cluster molecules based on explanatory variables (X) and separate dissimilar ones. We calculated SOFM clusters for a large number of molecules with human ADMET and kinase inhibitory data, and we showed that chemically similar molecules were in the same SOFM cluster, and within such clusters the QSAR models had significantly better predictability. Read More

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April 2014
1 Read
1 Citation

[Formulation of multiparticular drug delivery systems by compressing pellets into tablets].

Acta Pharm Hung 2013 ;83(4):134-42

Semmelweis Egyetem, Gyógyszerészi Intézet, 1092 Budapest, Hogyes Endre utca 7-9.

The use of multiparticulate drug delivery systems can contribute to more efficient and safe therapy while stability and incompatibility problems can be avoided as well. The aim of the present work was to review the possible ways of production of pellets containing multiparticulate units and studying the most important factors influencing the product quality attributes after tablet compression. The relationship between the formulation variables (compression pressures, different amounts of tableting excipients) and the dissolution profile of the gastroresistant coated beads were investigated. Read More

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[Development and biochemical characterization of EGFR/c-Met dual inhibitors].

Acta Pharm Hung 2013 ;83(4):121-33

Vichem Chemie Kutató Kft.

The epidermal growth factor receptor (EGFR) family has been well-known for more than ten years as the target of non-small lung carcinoma (NSCLC) which is one of the leading cause of mortality among the cancer types. The receptor tyrosine kinase inhibitors (gefitinib, erlotinib, lapatinib) which have been applied in the therapy, are not able to inhibit the progression of this disease perfectly because of resistance. It has been demonstrated that the amplification of mesenchymal-epithelial transition factor (c-Met) or secondary mutation of EGFR kinase causes the resistance against EGFR inhibitors in 18-20 percent of the cases. Read More

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April 2014
10 Reads