1,698 results match your criteria Acta paediatrica Japonica : Overseas edition[Journal]


Frequent detection of TrkA expression in human neuroblastoma cell lines.

Acta Paediatr Jpn 1998 Dec;40(6):644-6

Department of Pediatrics, Miyazaki Medical College, Japan.

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December 1998

Distribution of rotavirus VP4 genotype and VP7 serotype among Chinese children.

Acta Paediatr Jpn 1998 Dec;40(6):641-3

Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, China.

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December 1998

An infant with 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase/isomerase deficiency presenting with typical neonatal hepatitis syndrome: the first Japanese case.

Acta Paediatr Jpn 1998 Dec;40(6):638-40

Division of Pediatrics, Gifu Kouseiren Gihoku General Hospital, Japan.

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December 1998

Pocket Monster incident and low luminance visual stimuli: special reference to deep red flicker stimulation.

Acta Paediatr Jpn 1998 Dec;40(6):631-7

Yaotome Clinic, Tohoku University, Sendai, Japan.

On the evening of 16 December 1997 approximately 700 people around the nation (mostly children) were rushed to hospitals and treated for seizure symptoms. The youngsters had been watching the vastly popular TV animated cartoon series Pocket Monsters (Pokemon). We designated those individuals as a main group, who presumably had simultaneous occurrence of visually induced seizures. Read More

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December 1998

Photosensitive fits elicited by TV animation: an electroencephalographic study.

Acta Paediatr Jpn 1998 Dec;40(6):626-30

Department of Child Neurology, Okayama University Medical School, Japan.

Background: We carried out a clinical and electroencephalographic (EEG) study to reveal the pathophysiology of acute symptoms elicited by a TV animation program.

Methods: Clinical data and EEG were obtained from 20 patients ranging in age from 6 to 30 years. A pattern presentation and an intermittent photic stimulation were performed. Read More

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December 1998
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TV-animation induced seizures.

Authors:
K Iinuma

Acta Paediatr Jpn 1998 Dec;40(6):624-5

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.

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December 1998

Subclinical Sjögren's syndrome: a significant 67gallium accumulation in the orbits and parotid glands.

Acta Paediatr Jpn 1998 Dec;40(6):621-3

Division of Pediatrics, Iwate Prefectural Kitakami Hospital, Japan.

An 8-year-old girl with hypergammaglobulinemia showed an abnormal 67gallium accumulation in the orbits and parotid glands. Although she did not have any subjective siccant complaints, reported typical histopathological and sialographic changes suggesting Sjögren's syndrome (SjS) were observed in the salivary glands. Gallium scintigram might be a valuable and non-invasive diagnostic tool in the diagnosis of children with SjS without sicca symptoms. Read More

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December 1998

Trisomy 6 in a childhood acute mixed lineage leukemia.

Acta Paediatr Jpn 1998 Dec;40(6):616-20

Section of Pediatrics, Iwate Prefectural Kitakami Hospital, Japan.

The patient is a 12-year-old boy with acute mixed lineage leukemia (AMLL) and with a rare karyotype of trisomy 6. He was referred to our hospital with gingival swelling, bleeding at the conjunctiva and huge hepatosplenomegaly. Complete blood count revealed leukocytosis with 79% blasts, anemia and thrombocytopenia. Read More

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December 1998

Hereditary pancreatitis: report of a family from Turkey.

Acta Paediatr Jpn 1998 Dec;40(6):612-5

Department of Pediatrics, School of Medicine, University of Ankara, Turkey.

Chronic pancreatitis is a rare disease in children and is usually secondary to underlying diseases such as hereditary pancreatitis, cystic fibrosis, hyperlipidemia, prolonged malnutrition, gallstones or anomalies of the biliary-pancreatic duct system. Hereditary pancreatitis is a common cause of chronic pancreatitis in children but is often unrecognized until months or years later. We report here a family with hereditary pancreatitis in which four members are affected. Read More

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December 1998

An infant with Costello syndrome complicated with fatal hypertrophic obstructive cardiomyopathy.

Acta Paediatr Jpn 1998 Dec;40(6):608-11

Department of Pediatrics, Sapporo Medical University School of Medicine, Japan.

We report a 3-month-old girl with Costello syndrome complicating fatal hypertrophic obstructive cardiomyopathy. She had typical findings of this syndrome, slight dyspnea and persistent wheezing. Doppler echocardiography revealed asymmetric septal hypertrophy and systolic anterior movement of the anterior mitral leaflet. Read More

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December 1998

Infantile hemangioendothelioma of the thymus with massive pleural effusion and Kasabach--Merritt syndrome: histopathological, flow cytometrical analysis of the tumor.

Acta Paediatr Jpn 1998 Dec;40(6):604-7

Department of Pathology, Shizuoka Children's Hospital, Japan.

Infantile hemangioendothelioma of the thymus is a rare disease. We describe a patient who developed a large anterior mediastinal mass, severe thrombocytopenia and massive pleural effusion at 1 month of age. Glucocorticosteroid and irradiation therapy had no effect on either the tumor size or clinical symptoms and the tumor was resected subtotally. Read More

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December 1998

Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis.

Acta Paediatr Jpn 1998 Dec;40(6):600-3

Department of Pediatrics, Kochi Medical School, Japan.

We report the first case of the syndrome of periodic adrenocorticotropin (ACTH) and vasopressin (ADH) discharge associated with focal glomerulosclerosis. Approximately 30 cases of this syndrome have so far been reported in Japan, but no cases associated with renal dysfunction have yet been reported. The patient, a 10-year-old Japanese boy, was referred to our hospital because of recurrent attacks of vomiting. Read More

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December 1998

Hepatic damage in gluten sensitive enteropathy.

Acta Paediatr Jpn 1998 Dec;40(6):597-9

Department of Pediatric Gastroenterology, University of Ankara, Turkey.

Background: Gluten sensitive enteropathy has been reported to occur concomitantly with liver abnormalities, such as primary biliary cirrhosis, chronic active hepatitis and primary sclerosing cholangitis.

Methods: Duodenal biopsy was performed in nine children (all with short stature, five with chronic diarrhea and three with hepatosplenomegaly of unknown etiology) with a possible diagnosis of gluten sensitive enteropathy. All of the patients had different abnormalities in serum aminotransferase levels. Read More

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December 1998

Primary changes in liver damage by aspirin in rats.

Acta Paediatr Jpn 1998 Dec;40(6):593-6

Department of Pediatrics, Kochi Medical School, Japan.

Background: It has been known that acetylsalicylic acid (ASA) causes liver cell damage, however, its mechanisms remain obscure.

Methods And Results: To clarify the earliest change in the course of liver cell damage induced by oral administration of ASA, rats that had received ASA at 50 mg/kg and 150 mg/kg bodyweight orally for 7 days were investigated. Mitochondria were isolated for measurements of mitochondrial respiration, and for electron microscopic observations, small pieces of liver were excised and fixed. Read More

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December 1998

A simple and efficient purification of transduced cells by using green fluorescent protein gene as a selection marker.

Acta Paediatr Jpn 1998 Dec;40(6):586-92

Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.

Background: Simple and efficient method for the selection of transduced cells would greatly facilitate the clinical utilization of retrovirus vectors. We developed a therapeutic bicistronic retrovirus vector for Gaucher disease, MFG-GC-GFP, which contains the human glucocerebrosidase (GC) gene and the green fluorescent protein (GFP) gene of the jellyfish Aequorea victoria as a vital selection marker, and investigated its applicability as gene therapy for Gaucher disease.

Methods And Results: A packaging cell line, GP + envAM12, was transfected with MFG-GC-GFP and, thus, produced a high titer recombinant virus (1. Read More

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December 1998

CD48 expression on leukocytes in infectious diseases: flow cytometric analysis of surface antigen.

Acta Paediatr Jpn 1998 Dec;40(6):580-5

Department of Pediatrics, Yamagata University School of Medicine, Japan.

Background: The function of CD48, one of the pan leukocyte cell surface antigens, is not yet well understood. CD48 was recently shown to enhance the CD40-mediated activating signal to B lymphocytes. As CD48 is one of the activation antigens of monocytes, neutrophils and lymphocytes, a change of its expression on the cells could be expected in infectious diseases. Read More

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December 1998

Prognostic value of proliferating cell nuclear antigen immunostaining in pediatric rhabdomyosarcomas.

Acta Paediatr Jpn 1998 Dec;40(6):573-9

Institute of Oncology, Department of Pediatric Oncology, University of Istanbul, Turkey.

Background: The levels of proliferating cell nuclear antigen (PCNA) are almost negligible in long-term quiescent cells and increase dramatically during the cell cycle. Recently, the monoclonal antibodies to PCNA have been used to demonstrate the proliferative component of paraffin-embedded tumor tissues. It has been shown to be available as a simple histological marker of proliferative activity and the PCNA labeling index has been correlated with the prognosis of several malignant neoplasms. Read More

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December 1998

Effectiveness and safety of intravenous amiodarone in drug-resistant tachyarrhythmias of children.

Acta Paediatr Jpn 1998 Dec;40(6):567-72

Department of Pediatrics, Hacettepe University, Faculty of Medicine, Ankara, Turkey.

Background: Experience with pediatric use of intravenous amiodarone is limited. In this study, our experiences with intravenous amiodarone in children with acute life-threatening or chronic tachyarrhythmias are reviewed.

Methods And Results: Twelve patients, with a mean age of 3. Read More

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December 1998

Immunoglobulin G subclasses in wheezing infants.

Acta Paediatr Jpn 1998 Dec;40(6):564-6

Dokuz Eylül University Medical Faculty, Department of Pediatrics, Izmir, Turkey.

Background: The wheezing infant is a common but difficult patient to approach diagnostically. The prevalence of immunoglobulin (Ig) G subclass deficiency in wheezing infants is still controversial.

Methods: We studied the serum concentration of IgG subclasses in 38 wheezing infants (aged 6-24 months) who had not received systemic steroids before investigation and in 30 healthy age matched controls (aged 6-24 months). Read More

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December 1998

Juvenile chronic arthritis profile in Greek children.

Acta Paediatr Jpn 1998 Dec;40(6):558-63

1st Department of Paediatrics, Aghia Sophia Children's Hospital, Athens, Greece.

Background: Juvenile chronic arthritis (JCA) is the commonest autoimmune rheumatic disease in childhood and presents different clinical subtypes. Juvenile chronic arthritis is considered to be of a polygenic nature and its genetic background is still under investigation. The clinical profile of JCA in the Greek population has not been studied completely. Read More

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December 1998

Effect of body position on tidal volume and minute ventilation in very low birthweight infants.

Authors:
Y Itakura Y Ogawa

Acta Paediatr Jpn 1998 Dec;40(6):555-7

Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Japan.

Background: To progress the clinical treatment of neonates, especially in the management of respiration, we have to be able to measure their pulmonary function appropriately. Various methods have been developed, but little is known about the pulmonary function of very low birthweight infants (VLBWI) because of the difficulty in taking their measurements with existing equipment. We have developed a very low dead space pneumotachograph to measure lung function in VLBWI. Read More

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December 1998

Patient background of the Pokemon phenomenon: questionnaire studies in multiple pediatric clinics.

Acta Paediatr Jpn 1998 Dec;40(6):550-4

Department of Pediatrics, School of Medicine, Showa University, Tokyo, Japan.

Many children in Japan developed various neuropsychological problems, including seizures, while watching the program Pocket Monster, televised on 16 December 1997. To examine the basis for this incident, we have performed a survey of volunteering children and their parents who visited our pediatric clinics for other reasons from 8 January to 28 February 1998. Children and their parents filled out questionnaires. Read More

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December 1998

Clinical electroencephalographic study of nine pediatric patients with convulsion induced by the TV animation, Pocket Monster.

Acta Paediatr Jpn 1998 Dec;40(6):544-9

Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.

Background: To determine the usefulness of a few types of photic stimulation in patients with photo-convulsive response.

Methods: A clinical electroencephalographic study was conducted in nine children who developed convulsions and other symptoms while they watched the TV animation and were subsequently treated at the hospital. Photic stimulation was applied with their eyes open or closed. Read More

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December 1998

Constructing the human cerebral cortex during infancy and childhood: types and numbers of cortical columns and numbers of neurons in such columns at different age-points.

Acta Paediatr Jpn 1998 Dec;40(6):530-43

Department of Pathology and of Pediatrics, University of Southern California School of Medicine, USA.

This study examines JL Conel's data on neuron numbers in 35 human cortical areas for eight age points from 0 (birth) to 72 months, to analyze cortical columns, the presumed functional units of the cortex. For each cortical area at each age point, cortical surface divided by the square root of the area's neuron number gives cross-sectional areas with radii ranging from 180 microns at birth to 250 microns at 72 months. For the prefrontal cortex at birth and 48 months, these radii are approximately 2. Read More

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December 1998

Pediatric liver transplantation.

Authors:
A Dhawan P Muiesan

Acta Paediatr Jpn 1998 Dec;40(6):525-9

Department of Child Health, King's College Hospital, Denmark Hill, London, UK.

Liver transplantation in children has become a treatment of choice for end-stage liver disease. Both graft and patient survival has significantly improved over the last two decades. The major factor contributing towards improved survival is availability of cyclosporin. Read More

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December 1998

Encephalopathy and cytomegalovirus colitis in an AIDS child.

Acta Paediatr Jpn 1998 Oct;40(5):515-22

Department of Pediatrics, Osaka City General Hospital, Japan.

A 2-year-old girl, who had prolonged thrush and spastic diplegia, was found to have a mother-to-child vertical transmission of human immunodeficiency virus type-1 (HIV). A brain computed tomography scan revealed a symmetrical calcification on the bilateral basal ganglia and periventricular white matter. She had an acquired immune deficiency syndrome (AIDS) encephalopathy of pure dominant pyramidal tract disorder without an intellectual deficit. Read More

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October 1998

Vertical infection of human immunodeficiency virus as an imported infectious disease.

Acta Paediatr Jpn 1998 Oct;40(5):510-4

Department of Pediatrics, Tokyo Metropolitan Komagome Hospital, Japan.

Background And Methods: In Japan, 26 children who vertically acquired human immunodeficiency virus (HIV) infection had been reported as at February 1997. Little information was published about their epidemiological backgrounds and the rate of perinatal HIV transmission in Japan remains unknown. To learn the epidemiological features of perinatal HIV infection in Japan, we examined the medical records of five perinatally infected children. Read More

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October 1998

Vertical transmission of human immunodeficiency virus type 1 in Japan, 1989-1997: presence of two subtypes B and E with subtype E predominance. National Cooperative Study Investigators on Vertical Transmission of HIV-1.

Acta Paediatr Jpn 1998 Oct;40(5):503-9

National Cooperative Study Group on Vertical Transmission of HIV-1, Tokyo, Japan.

A collaborative group for studying vertical transmission of human immunodeficiency virus (HIV)-1 in pregnant women and their babies was established in Japan in 1989. Forty-two infants, including 13 HIV-1-infected, 25 uninfected and four of undetermined status and 15 control children born to HIV-1 negative mothers were diagnosed and followed from birth to 1.5 years. Read More

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October 1998

Epidemiology, clinical characteristics and natural history of vertically transmitted human immunodeficiency virus-1 infection in Japan.

Authors:
K Akagi

Acta Paediatr Jpn 1998 Oct;40(5):496-502

Division of Infection, Immunology and Rheumatology, Kanagawa Children's Medical Center, Yokohama, Japan.

Background: According to the Ministry of Health and Welfare AIDS Surveillance Committee's report on vertically transmitted human immunodeficiency virus (HIV) infection, there have been eight children with acquired immune deficiency syndrome (AIDS) and 18 children with HIV infection in Japan, totalling 26 in all as of February 1997. A search of the literature fails to reveal any report that deals with many cases of vertically transmitted HIV infection in Japan.

Methods: A primary questionnaire survey was taken of the main medical institutions across the country, followed by a secondary questionnaire survey of physicians and pediatricians who treated the disease. Read More

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October 1998
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Type III D mucopolysaccharidosis (Sanfilippo D): clinical course and symptoms.

Acta Paediatr Jpn 1998 Oct;40(5):492-4

Department of Metabolic Diseases, Children's Memorial Health Institute, Warsaw, Poland.

A case of a rare form of Sanfilippo disease, mucopolysaccharidosis type III D is presented. The cause of the disease is a deficit of N-acetylglycosamine-6-sulfate sulfatase. Differences in clinical course and symptoms with type A and B Sanfilippo disease are shown (later presentation of symptoms, milder course, lack of distinct psychomotor regression and differences in characteristic phenotypic traits, such as facial features, joint contracture, tall height). Read More

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October 1998

Henoch Schönlein purpura and amebiasis.

Acta Paediatr Jpn 1998 Oct;40(5):489-91

Department of Nephrology, Dr Sami Ulus Children's Hospital, Ankara, Turkey.

The pathogenesis of Henoch Schönlein purpura (HSP) is unknown but is believed to result from an immune complex reaction to various antigenic stimuli, such as infectious agents. However, its association with Entamoeba histolytica has not been reported before. We present an 11-year-old boy with HSP, confirmed by the demonstration of leukocytoclastic vasculitis from skin and diffuse endocapillary proliferative glomerulonephritis, together with immunoglobulin A and complement component C3 deposition from renal biopsies. Read More

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October 1998

Human parvovirus B19-associated thrombocytopenic purpura.

Acta Paediatr Jpn 1998 Oct;40(5):486-8

Department of Paediatrics, Showa Hospital, Aichi, Japan.

We report two patients who presented with thrombocytopenic purpura (TP) associated with primary human parvovirus B19 (B19) infection. One patient also had transient liver dysfunction. In both cases, B19-DNA was detected in serum and bone marrow by polymerase chain reaction. Read More

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October 1998

Prolonged suppressed thyroid-stimulating hormone levels in hyperthyroidism in a neonate born to a mother with Graves' disease.

Acta Paediatr Jpn 1998 Oct;40(5):483-5

Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan.

We report here a case of neonatal hyperthyroidism born to a mother, whose pregnancy was complicated by poorly controlled Graves' disease. The patient demonstrated exophthalmos and marked goiter at birth, indicating the existence of thyrotoxicosis in utero. The mother's Graves' disease was well controlled in the third trimester, resulting in a slightly lower level of free thyroxine (FT4) in the umbilical cord blood serum; however, thyroid-stimulating hormone (TSH) was undetectable. Read More

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October 1998

Transient extreme spindles in a case of subacute Mycoplasma pneumoniae encephalitis.

Acta Paediatr Jpn 1998 Oct;40(5):479-82

Division of Child Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.

We describe a 4-year-old boy with delirium including somnolence, irritability, agitation and visual hallucination, associated with Mycoplasma pneumoniae (MP) encephalitis. The MP encephalitis was diagnosed from increased MP-antibody (> 1:1280). Electroencephalography during sleep revealed continuous 9 Hz fast wave activity over the bilateral frontocentral regions, which was thought to represent extreme spindles. Read More

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October 1998

Long survivors with Ki-1 lymphoma having t(2;5) (p23;q35). Does the presence or absence of t(2;5) influence the prognosis of patients with Ki-1 lymphoma?

Acta Paediatr Jpn 1998 Oct;40(5):474-8

Department of Pediatrics, Kohnan Hospital, Sapporo, Japan.

We experienced three patients with CD30+ diffuse large cell lymphoma having chromosomal abnormalities. The first patient was an 8-year-old girl with bilateral cervical lymphadenopathy. A biopsy of a cervical lymph node revealed diffuse large cell lymphoma (stage III), positive for CD30 and a chromosomal abnormality, t(2;5). Read More

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October 1998

Pseudosarcomatous myofibroblastic tumor of the urinary bladder with massive intraperitoneal hemorrhage in a child.

Acta Paediatr Jpn 1998 Oct;40(5):470-3

Division of Pediatrics, Komatsushima Red Cross Hospital, Tokushima, Japan.

A 3-year-old boy presented with persistent abdominal pain, hematuria and facial pallor with progressive anemia. A computed tomography scan showed a massive intraperitoneal hemorrhage and tumor mass in the bladder. Histological examinations of the resected tumor revealed findings of pseudosarcomatous myofibroblastic tumor (PMT). Read More

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October 1998

Yolk sac tumor with a unique uniform hepatoid pattern histology.

Acta Paediatr Jpn 1998 Oct;40(5):466-9

Department of Pediatrics, Kanazawa University School of Medicine, Ishikawa, Japan.

Background: Yolk sac tumors (YST) exhibit several different histological subtypes and the mechanisms of cellular differentiation and prognosis of each subtype remain unknown.

Results: We report two infants with sacrococcygeal YST; one represented a typical histological subtype and the other showed a hepatoid subtype with uniform histology. The isoform of alpha-fetoprotein (AFP) in the patient with the hepatoid pattern was examined by lectin-affinity immunoelectrophoresis and represented as a YST, but not hepatocellular, subtype. Read More

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October 1998

Microfocal radiography in the diagnosis of childhood renal osteodystrophy.

Acta Paediatr Jpn 1998 Oct;40(5):461-5

Dr Sami Ulus Children's Hospital, Department of Nephrology, Ankara, Turkey.

Background: Renal osteodystrophy is common in children with chronic renal failure (CRF) and X-ray is an intensive method in the diagnosis of the disease. In this study we compared microfocal radiography with conventional method for the diagnosis of renal osteodystrophy.

Methods: The X-rays of left wrists of 21 children with CRF and chronic renal insufficiency were taken by conventional and microfocal methods. Read More

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October 1998

Celiac disease in Turkish short-statured children and the value of antigliadin antibody in diagnosis.

Acta Paediatr Jpn 1998 Oct;40(5):457-60

Department of Pediatric Gastroenterology, Ankara University Faculty of Medicine, Turkey.

Background: It is generally accepted that celiac disease (CD) must always be taken into consideration when dealing with children manifesting growth failure. It is, therefore, important to have laboratory tests capable of detecting patients who should undergo intestinal biopsy. In this study, we have prospectively evaluated clinical characteristics, gliadin antibody measurements and duodenal biopsies in 47 children with short stature and without gastrointestinal symptoms, in order to determine the incidence of CD and the diagnostic value of immunoglobulin (Ig)A and IgG antigliadin antibodies (AGA) for CD. Read More

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October 1998

Stretched minimal diameter of the ductus and coil occlusion.

Acta Paediatr Jpn 1998 Oct;40(5):453-6

Department of Pediatrics, Sapporo Medical University, School of Medicine, Japan.

Background: Stretching of the ductus was supposed to determine the size mismatch of the coil with the ductus in coil occlusion that results in residual leak or migration.

Methods: We measured the minimal diameter (D) and the stretched minimal diameter (S) of the ductus in 12 patients with patent ductus arteriosus (PDA). The stretch index (SI) was calculated as S divided by D. Read More

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October 1998

Characterization of developmental changes in EEG-gamma band activity during childhood using the autoregressive model.

Authors:
T Takano T Ogawa

Acta Paediatr Jpn 1998 Oct;40(5):446-52

Department of Pediatrics, Oita Medical University School of Medicine, Hasama, Japan.

Background: We characterized developmental changes in the EEG-gamma band during childhood using the autoregressive (AR) model, which was previously developed and described in our laboratory.

Methods: The subjects comprised 707 healthy children ranging in age from 3 to 12 years. Electroencephalographs (EEG) were recorded from Fp1, Fp2, C3, C4, O1 and O2, monopolar leads referenced to the ear during quiet wakefulness (eyes closed). Read More

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October 1998

Community-acquired severe staphylococcal septicemia in children: the relationship with blunt trauma.

Acta Paediatr Jpn 1998 Oct;40(5):441-5

Department of Pediatric Infectious Diseases, Clinical Immunology and Allergy, Faculty of Medicine, Istanbul University, Turkey.

Background: With the aim of establishing the role of blunt trauma, a trauma without any fracture or obvious wound, as a risk factor in children who were admitted for community-acquired severe staphylococcal septicemia with various organ involvement, 63 patients were investigated during a seven-year study period. All children were previously healthy.

Results: Blunt trauma was present in 12 (46%) of 26 septicemic patients in whom skeletal infections were diagnosed and the relative risk of trauma was high (odds ratio 15. Read More

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October 1998

Serotypes and antibacterial susceptibility of pneumococci isolated from children with infections in Ankara in relation to proposed pneumococcal vaccine coverage.

Acta Paediatr Jpn 1998 Oct;40(5):437-40

Department of Pediatric Infectious Diseases, Hacettepe University, School of Medicine, Ankara, Turkey.

Background: Streptococcus pneumoniae is an important pathogen for both children and adults. Although there is an effective vaccine, it is not protective under 2 years of age and common serotypes differ from one location to another.

Methods: A total of 44 Streptococcus pneumoniae isolates were recovered from clinical specimens of children in various hospitals in Ankara, Turkey. Read More

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October 1998

Clinical survey of congenital cytomegalovirus infection in Japan.

Acta Paediatr Jpn 1998 Oct;40(5):432-6

Department of Pediatrics, Nagoya University School of Medicine, Japan.

Background: The clinical features of congenital cytomegalovirus (CMV) infection in countries with a higher percentage of maternal seropositivity for CMV has rarely been reported. We conducted a national survey for the first time in Japan to investigate the prevalence of congenital CMV infection.

Methods: Questionnaires were sent in 1994 to pediatricians and obstetricians of 3398 hospitals with either more than 100 beds or a neonatal intensive care unit (NICU). Read More

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October 1998

Plasma platelet-activating factor levels in newborn infants with and without perinatal asphyxia: is it an additional marker of perinatal asphyxia?

Acta Paediatr Jpn 1998 Oct;40(5):427-31

Ege University Medical Faculty, Department of Pediatrics, Izmir, Turkey.

Background: Hypoxic-ischemic encephalopathy (HIE) is still a very important cause of neonatal mortality and morbidity. Recently platelet-activating factor (PAF) has been accused of being responsible for the neuronal damage in hypoxic-ischemic brain.

Methods: Therefore, we conducted a study in newborns with perinatal asphyxia to try to show the relationship between the clinical severity and plasma PAF levels. Read More

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October 1998

Values for urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase in normal healthy infants.

Acta Paediatr Jpn 1998 Oct;40(5):424-6

Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.

Background: Measuring urinary beta 2 microglobin (B2M) and N-acetyl-beta-D-glucosaminidase (NAG) excretion is widely used as a valuable clinical tool in assessing renal tubular lesions. However, few data are available on normal values for urinary excretion of B2M and NAG in infancy.

Methods: Urinary B2M and NAG were measured in healthy infants. Read More

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October 1998

Mortality among patients with a history of Kawasaki disease: the third look. The Kawasaki Disease Follow-up Group.

Acta Paediatr Jpn 1998 Oct;40(5):419-23

Department of Public Health, Jichi Medical School, Minamikawachi, Japan.

Background: Long-term prognosis of Kawasaki disease is still unclear.

Methods: In a cohort study, 6576 patients with Kawasaki disease were observed from their first medical encounter because of the disease through the end of 1994, or until death. Standardized mortality ratios (SMR) with 95% confidence intervals (CI) were calculated with vital statistics data of Japan used for the control. Read More

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October 1998

Quantitative microscopic anatomy, illustrated by its potential role in furthering understanding of the processes of structuring the developing human cerebral cortex.

Acta Paediatr Jpn 1998 Oct;40(5):400-18

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, California, USA.

In this study, we searched for patterns in selected, quantitative microscopic features of the developing postnatal human cortex for 35 cytoarchitectural areas at eight age points from birth to 72 months. These data come from the largest extant survey of the microscopic features of the developing postnatal human cerebral cortex (JL Conel, 1939-67). In contrast to Jacobson's proposal that cortical surface area increases in proportion to brain weight, Conel's data show that surface area increases as brain weight2/3, with the maximal rate of increase in both brain weight and cortical surface area occurring from 1 to 3 months. Read More

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October 1998

Prevalence of GBV-C/HGV infection in pregnant Japanese women.

Acta Paediatr Jpn 1998 Aug;40(4):385-6

Department of Pediatrics, Nagoya City University Medical School, Japan.

Recently, a novel viral agent, hepatitis G virus, was identified by independent researchers from the serum of patients with liver disease, and termed GBV-C or HGV. At present, GBV-C and HGV are considered to be separate isolates of the same virus; however, the role of this virus in acute and chronic liver disease remains uncertain. Although vertical transmission is known to be one of the routes of transmission, the prevalence of GBV-C/HGV viremia in pregnant Japanese women is unknown. Read More

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