8,593 results match your criteria Acta neurologica Scandinavica[Journal]


Parental stress in a sample of children with epilepsy.

Acta Neurol Scand 2019 Apr 19. Epub 2019 Apr 19.

Child and Adolescent Neuropsychiatry, Medical School, University of Salerno, Via Giovanni Paolo II, 132, Fisciano (SA), Italy.

To assess maternal and paternal stress in 2 groups of children with different types of epilepsy, at the time of diagnosis and after one year of follow-up. We investigated parental stress in a sample of 85 children aged between 2-14 years, divided into two groups based on the diagnosis: Group 1 (50 patients) with Childhood Absence Epilepsy or Idiopathic Focal Epilepsy with Rolandic discharges; Group 2 (35 patients) with different forms of drug-resistant Epilepsy. Parents independently completed the Parental Stress Index-Short Form at Time 0, when they received the diagnosis and patients started therapy, and at Time 1, after 1 year of follow-up. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13106
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http://dx.doi.org/10.1111/ane.13106DOI Listing
April 2019
1 Read

Aspirin reduced recurrent stroke risk in patients with lacunar stroke.

Acta Neurol Scand 2019 Apr 19. Epub 2019 Apr 19.

Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100037, China.

Objectives: Lacunar stroke had an unfavorable prognosis in the long term with a high risk of recurrent stroke, aspirin has been widely used to prevent ischemic stroke, but data on the effect of antiplatelet therapy on lacunar infarction are limited. We investigated the long-term effect of aspirin treatment on stroke recurrence risk in patients with lacunar stroke in a multicenter prospective cohort.

Methods: Between November 2000 and November 2001, 2000 consecutive stroke patients (age 35-74 years) were recruited from seven clinical centers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13105
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http://dx.doi.org/10.1111/ane.13105DOI Listing
April 2019
1 Read

Buccally Absorbed vs Intravenous Prochlorperazine for Treatment of Migraines Headaches.

Acta Neurol Scand 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Los Angeles, US.

Objective: To compare the efficacy of buccally absorbed prochlorperazine (BAP) to intravenous prochlorperazine (IVP) for the abortive treatment of migraine headaches.

Methods: Randomized double-blind trial. Eighty subjects aged 18-65 presenting with migraines to the ED of a safety-net, urban hospital. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13104
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http://dx.doi.org/10.1111/ane.13104DOI Listing
April 2019
1 Read

Cycle ergometer training versus resistance training in ICU-acquired weakness.

Acta Neurol Scand 2019 Apr 12. Epub 2019 Apr 12.

HELIOS Klinik Kipfenberg, Kipfenberg, Germany.

Objectives: We investigated the effectiveness of cycle ergometer training and resistance training to enhance the efficiency of standard care to improve walking ability, muscular strength of the lower limbs, cardiovascular endurance and health-related quality of life during in-patient rehabilitation in intensive care unit acquired weakness.

Materials & Methods: Thirty-nine patients with severe to moderate walking disability were enrolled in one of three experimental groups: a) ergometer training group, b) resistance training group and c) control group (standard care only). Intervention was applied five days a week over a 4-week period during in-patient neurological rehabilitation. Read More

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http://dx.doi.org/10.1111/ane.13102DOI Listing
April 2019
12 Reads

Neuroimaging and neuropathological findings in essential tremor.

Acta Neurol Scand 2019 Apr 11. Epub 2019 Apr 11.

Third Department of Neurology, Aristotle University of Thessaloniki, Greece.

Essential Tremor is a chronic neurological syndrome of heterogenous clinical phenotypes and multiple aetiologies. Numerous studies have been done in order to investigate the pathological, neuroimaging, physiological and clinical features of essential tremor; however a clear pathyphysiological mechanism has not been identified. One of the brain structures that has been extensively investigated at the macroscopic and the microscopic level in the cerebellum. Read More

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http://dx.doi.org/10.1111/ane.13101DOI Listing
April 2019
2 Reads

U-shaped relationship between hemoglobin level and severity of ischemic stroke.

Acta Neurol Scand 2019 Apr 10. Epub 2019 Apr 10.

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Background And Aim: We aimed to explore the relation between hemoglobin level and ischemic stroke severity and short-term improvement in patients admitted to hospital within 3 hours of stroke onset.

Methods: The relation between stroke severity and hemoglobin was explored by locally weighted scatterplot smoothing (lowess smoother) curves. The effect of hemoglobin on short-term outcome was determined by means of linear regression analyses with NIHSS score day 7 as dependent variable after adjusting for confounders including NIHSS score on admission. Read More

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http://dx.doi.org/10.1111/ane.13100DOI Listing
April 2019
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Rasagiline and safinamide as a dopamine-sparing therapy for parkinson's disease.

Acta Neurol Scand 2019 Apr 8. Epub 2019 Apr 8.

Department of Psychiatry Hospital, Sant Joan Despí Moisès Broggi and Hospital General de l'Hospitalet. Consorci Sanitari Integral, Barcelona, Spain.

Objectives: To evaluate whether the prescription of monoamine oxidase B inhibitors (MAOB-I), rasagiline and safinamide, contribute to the reduction of levodopa and/or dopamine agonists (DA) dose in order to minimize adverse effects.

Materials And Methods: A total of 724 patients with Parkinson's disease (PD) have been prospectively included in our database since the year 2000, representing a total of 5,124 visits. For each patient and visit, antiparkinsonian treatment was recorded. Read More

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http://dx.doi.org/10.1111/ane.13096DOI Listing

Challenges in epilepsy - the perspective of Norwegian epilepsy patients.

Acta Neurol Scand 2019 Apr 8. Epub 2019 Apr 8.

The National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital, Norway.

Objectives: For most people with epilepsy (PWE), problems that are not directly related to seizures may constitute major challenges in everyday life. The purpose of this study was to determine the extent of these challenges and any risk factors for their occurrence among PWE in Norway, based on the patients' own perspective.

Materials And Methods: We used a web-based survey to ask PWE visiting the homepage of the Norwegian Epilepsy Association about different everyday challenges. Read More

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http://dx.doi.org/10.1111/ane.13098DOI Listing

Real life use of oral disease modifying treatments in Austria.

Acta Neurol Scand 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurology, Medical University of Vienna, Vienna, Austria.

Objectives: To compare the efficacy, frequencies and reasons for treatment interruption of fingolimod, dimethyl fumarate (DMF) or teriflunomide in a nationwide observational cohort using prospectively collected data.

Materials And Methods: Two cohorts of patients with relapsing-remitting multiple sclerosis (RRMS) starting treatment with fingolimod, dimethyl fumarate or teriflunomide documented in the Austrian MS Treatment Registry (AMSTR) since 2014 and either staying on therapy for at least 12 months (12m cohort) or having at least one follow-up visit (total cohort). The 12m cohort included 664 RRMS patients: 315 in the fingolimod, 232 in the DMF and 117 in the teriflunomide group. Read More

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http://dx.doi.org/10.1111/ane.13097DOI Listing

Levels of anger in epilepsy patients treated with eslicarbazepine acetate.

Acta Neurol Scand 2019 Apr 6. Epub 2019 Apr 6.

Epilepsy Unit. Neurology Department. Vall d'Hebron Hospital. Passeig Vall d'Hebron, 119-129. 08035, Barcelona. Spain.

Introduction: Aggressive behavior is commonly associated with epilepsy and, can be influenced by the antiepileptic drugs (AEDs) taken. Sodium channel blockers, specifically the carboxamides derivatives carbamazepine and oxcarbazepine, are some of the AEDs considered to have a favorable psychiatric effect profile.

Objectives: We aimed to assess whether the carboxamide analogue eslicarbazepine acetate (ESL) has any effect on the levels of anger in patients with epilepsy. Read More

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http://dx.doi.org/10.1111/ane.13099DOI Listing
April 2019
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Quality of life in Parkinson's disease: A gender specific perspective.

Acta Neurol Scand 2019 Apr 6. Epub 2019 Apr 6.

Movement Disorders Unit, Tel-Aviv Sourasky Medical Center.

Objectives: The epidemiology, manifestations and course of Parkinson's disease (PD) may differ in men and women. Assessments of severity of the illness and quality of life (QoL), and the burden on their caregivers (CG) may change as the disease advances. We determined gender differences in assessment by PD patients themselves and by their CGs. Read More

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http://dx.doi.org/10.1111/ane.13095DOI Listing
April 2019
2 Reads

Intrathecal inflammation in young stroke.

Acta Neurol Scand 2019 Apr 2. Epub 2019 Apr 2.

Departement of Neurology, University Medicine Greifswald, Greifswald, Germany.

Objectives: Correct identification of inflammatory etiologies of stroke is of outmost importance as they require treatment of the underlying disease. Aim of this study was to determine the prevalence of inflammatory changes in cerebrospinal fluid (CSF) observed in young cryptogenic stroke patients.

Materials And Methods: Of 6476 records of patients diagnosed with ischemic stroke, 278 had confirmed ischemia in brain imaging and received lumbar puncture. Read More

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http://dx.doi.org/10.1111/ane.13094DOI Listing
April 2019
3 Reads

A unicenter, prospective study of Guillain-Barré syndrome in Spain.

Acta Neurol Scand 2019 Mar 31. Epub 2019 Mar 31.

Service of Neurology, University Hospital "Marqués de Valdecilla (IDIVAL)", University of Cantabria, and "Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)", Santander, Spain.

Objective: We report a prospective study analysing clinical characteristics, subtyping and prognosis in Guillain-Barré syndrome (GBS).

Method: The study was based on consecutive GBS patients admitted between 2009 and 2017. Disability was serially assessed using the GBS disability scale. Read More

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http://dx.doi.org/10.1111/ane.13092DOI Listing
March 2019
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Recurrent ischemic stroke: Incidence, predictors, and impact on mortality.

Acta Neurol Scand 2019 Mar 31. Epub 2019 Mar 31.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Background And Purpose: Recurrent ischemic stroke (IS) or TIA is frequent with a considerable variation in incidence and mortality across populations. Current data on stroke recurrence and mortality are useful to examine trends, risk factors, and treatment effects. In this study, we calculated the incidence of recurrent IS or TIA in a hospital-based stroke population in Western Norway, investigated recurrence factors, and estimated the effect of recurrence on all-cause mortality. Read More

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http://dx.doi.org/10.1111/ane.13093DOI Listing
March 2019
2 Reads

What is the meaning of PASAT rejection in multiple sclerosis?

Acta Neurol Scand 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurology, San Carlos Institute for Health Research (IdISSC), Universidad Complutense de Madrid, Madrid, Spain.

Background: Paced Auditory Serial Addition Test (PASAT) is one of the most used neuropsychological tests in multiple sclerosis (MS), specially for screening. However, the applicability of the test is limited because of the rejection of the test completion in a proportion of patients. We aimed to investigate the clinical, neuropsychological, and MRI findings associated to PASAT rejection. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13090
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http://dx.doi.org/10.1111/ane.13090DOI Listing
March 2019
3 Reads

Interaction among GRIK2 gene on epilepsy susceptibility in Chinese children.

Acta Neurol Scand 2019 Mar 25. Epub 2019 Mar 25.

Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China.

Aims: The association of single nucleotide polymorphisms (SNPs) of glutamate receptor 2 (GRIK2) gene, as well as gene-gene interaction with the risk of early-onset epilepsy susceptibility, was studied in Chinese children.

Methods: Generalized multi-factor dimension reduction (GMDR) is used to identify the optimal linkage between interaction among four SNPs and early-onset epilepsy susceptibility. Logistic regression was performed to assess association between four SNPs within GRIK2 gene and the risk of epilepsy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13089
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http://dx.doi.org/10.1111/ane.13089DOI Listing
March 2019
3 Reads

Serum insulin-like growth factor-1 levels in neurodegenerative diseases.

Acta Neurol Scand 2019 Mar 23. Epub 2019 Mar 23.

Department of Neurology, Dokkyo Medical University, Mibu, Japan.

Background: We investigated serum insulin-like growth factor (IGF)-1 levels in patients with neurodegenerative diseases and correlated these levels with clinical parameters.

Methods: One hundred and fifty-six patients with neurodegenerative diseases were included in this study, and serum IGF-1 levels were determined.

Results: Serum IGF-1 levels (mean ± standard error) were not significantly different among the patients with different neurodegenerative diseases: Parkinson's disease (PD; n = 73), 112. Read More

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http://dx.doi.org/10.1111/ane.13091DOI Listing
March 2019
1 Read

Patient-reported outcomes in Friedreich's ataxia after withdrawal from idebenone.

Acta Neurol Scand 2019 Mar 18. Epub 2019 Mar 18.

Department of Molecular Neuroscience, Ataxia Centre, UCL Institute of Neurology, Queen Square, London, UK.

Objectives: Friedreich's ataxia is the most common inherited ataxia, and pathogenesis is known to involve mitochondrial oxidative stress. Idebenone is a potent antioxidant which has already been evaluated in several clinical trials in FRDA, with reports of symptomatic benefit but inconclusive objective results. Following patient consultation on design, we have completed a treatment-withdrawal study to establish whether patients could correctly determine their treatment allocation to placebo or idebenone. Read More

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http://dx.doi.org/10.1111/ane.13088DOI Listing
March 2019
2 Reads

Prestige of neurological disorders among future neurologists in Norway.

Acta Neurol Scand 2019 Mar 9. Epub 2019 Mar 9.

Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

Background: Neurology has increasing subspecialization. Some disorders, such as cerebrovascular diseases, dementia and headache, are highly prevalent in the general population, while others, such as movement disorders and multiple sclerosis, are rarer. Thus, there may be a mismatch between neurologists' interests and the population needs. Read More

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http://doi.wiley.com/10.1111/ane.13087
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http://dx.doi.org/10.1111/ane.13087DOI Listing
March 2019
6 Reads

Uncovering health and social care needs among myotonic dystrophy patients: Utility of the Needs and Provisions Complexity Scale.

Acta Neurol Scand 2019 Mar 8. Epub 2019 Mar 8.

Department of Neurohabilitation, Oslo University Hospital Ullevål, Oslo, Norway.

Objectives: Myotonic dystrophy type 1 (DM1) is a slowly progressive multisystem disorder. Guidelines recommend multidisciplinary follow-up. We aimed to investigate the presence of unmet health and social care needs among patients with DM1 and whether unmet needs correlated with motor function, cognitive impairments, or quality of life. Read More

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http://dx.doi.org/10.1111/ane.13086DOI Listing
March 2019
2.395 Impact Factor

Mood, anxiety, and perceived quality of life in adults with epilepsy and intellectual disability.

Acta Neurol Scand 2019 Feb 28. Epub 2019 Feb 28.

Department of Behavioral Sciences, Kempenhaeghe Epilepsy Center, Heeze, The Netherlands.

Objective: Depression and anxiety symptoms are common among patients with epilepsy, but are relatively under-researched in patients with both epilepsy and intellectual disability (ID). The aim was to investigate whether epilepsy and ID characteristics are associated with mood, anxiety, and quality of life.

Materials And Methods: Adult patients with epilepsy and ID who rely on tertiary epilepsy care were included (N = 189). Read More

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http://dx.doi.org/10.1111/ane.13085DOI Listing
February 2019
3 Reads

Dyskinesia and FAB score predict future falling in Parkinson's disease.

Acta Neurol Scand 2019 Mar 1. Epub 2019 Mar 1.

Department of Health Sciences, Lund University, Lund, Sweden.

A growing body of research highlights the importance of cognition for prediction of falls in Parkinson's disease (PD). However, a previously proposed prediction model for future near falls and falls in PD, which includes history of near falls, tandem gait, and retropulsion, was developed without considering cognitive impairment. Therefore, by using a sample of 64 individuals with relatively mild PD and not excluding those with impaired cognition we aimed to externally validate the previously proposed model as well as to explore the value of additional predictors that also consider cognitive impairment. Read More

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http://dx.doi.org/10.1111/ane.13084DOI Listing

Adult dyskinetic cerebral palsy: Upper limb movement and muscle function.

Acta Neurol Scand 2019 Feb 27. Epub 2019 Feb 27.

Human Motion Analysis Laboratory, Department of Rehabilitation Science, Universidade Nove de Julho, São Paulo, Brazil.

Aim: The aim of this study was to characterize upper limb motor function during a comparative analysis of electromyographic and upper limb movement analysis during drinking between healthy adults and individuals with DCP.

Method: Fifteen healthy individuals (CG) and fifteen individuals with DCP (DG) participated in the study. Upper limb function was analyzed during drinking and consisted of a task divided into three phases: the going, the adjustment, and the return. Read More

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http://dx.doi.org/10.1111/ane.13083DOI Listing
February 2019
1 Read

Emotions towards magnetic resonance imaging in people with multiple sclerosis.

Acta Neurol Scand 2019 Feb 25. Epub 2019 Feb 25.

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Objectives: People with multiple sclerosis (pwMS) often have magnetic resonance imaging (MRI) examinations. While MRI can help guide MS management, it may be a source of anxiety for pwMS. We aimed to develop and validate a questionnaire on the "EMotions and Attitudes towards MRI" (MRI-EMA). Read More

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http://dx.doi.org/10.1111/ane.13082DOI Listing
February 2019
1 Read

MUL1 gene polymorphisms and Parkinson's disease risk.

Acta Neurol Scand 2019 May 14;139(5):483-487. Epub 2019 Mar 14.

Neurology Department of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.

Objectives: Parkinson's disease (PD) is afflicting millions of patients worldwide, and gene therapy may be a hope for cure. Recent researches have shown that MUL1 may play a key role in PD pathogenesis, but no specific genetic variants have been identified. This study was aimed to verify the hypothesis that variants in MUL1 gene were associated with PD risk in a Chinese cohort. Read More

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http://dx.doi.org/10.1111/ane.13081DOI Listing
May 2019
1 Read

Investigative practice into sudden death in epilepsy: A global survey.

Acta Neurol Scand 2019 May 4;139(5):476-482. Epub 2019 Mar 4.

Department of Intellectual Disability Neuropsychiatry, Cornwall Partnership NHS Foundation Trust, Truro, UK.

Objectives: Sudden death is a recognized consequence of epilepsy. Little is known about the practice of confirming the cause of sudden death from most nations. We sought to determine how often autopsy is undertaken, clinician confidence in cause of death and identify the factors which may influence autopsy utilization. Read More

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http://dx.doi.org/10.1111/ane.13080DOI Listing
May 2019
3 Reads
2.395 Impact Factor

Structural and functional connectivity in newly diagnosed juvenile myoclonic epilepsy.

Acta Neurol Scand 2019 May 27;139(5):469-475. Epub 2019 Feb 27.

Department of Neurology, Haeundae Paik Hospital, Busan, Korea.

Objectives: We aimed to evaluate structural and functional connectivity of patients with newly diagnosed juvenile myoclonic epilepsy (JME) compared to healthy subjects.

Methods: We enrolled 36 patients with a diagnosis of JME, who were newly diagnosed and drug-naïve. They underwent T1-weighted imaging, and structural volumes were calculated using FreeSurfer software. Read More

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http://dx.doi.org/10.1111/ane.13079DOI Listing
May 2019
1 Read

Statins and the risk of bleeding in patients taking dabigatran.

Acta Neurol Scand 2019 May 4;139(5):455-461. Epub 2019 Mar 4.

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Objectives: Dabigatran etexilate is a direct thrombin inhibitor that clinicians increasingly prescribe to prevent stroke in patients with non-valvular atrial fibrillation (NVAF). Clinicians also commonly prescribe statins for primary and secondary prevention of cardiovascular diseases. Little is known about the bleeding risk in patients taking a statin and dabigatran together. Read More

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http://dx.doi.org/10.1111/ane.13077DOI Listing
May 2019
5 Reads

Comparison of plasma and cerebrospinal fluid neurofilament light in a multiple sclerosis trial.

Acta Neurol Scand 2019 May 5;139(5):462-468. Epub 2019 Mar 5.

Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden.

Objective: The main objective of this study was to evaluate the axonal component neurofilament light protein (NFL) in plasma and cerebrospinal fluid (CSF) as an outcome measure in a clinical trial on disease-modifying treatments in multiple sclerosis.

Materials And Methods: Seventy-five patients with clinically stable relapsing-remitting multiple sclerosis (RRMS) participating in the clinical trial "Switch-To RItuXimab in MS" (STRIX-MS) were switched to rituximab from first-line injectable therapy and then followed up for 2 years. Thirty patients from the extension trial (STRIX-MS extension), accepting repeated lumbar punctures, were followed up for an additional 3 years. Read More

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http://dx.doi.org/10.1111/ane.13078DOI Listing
May 2019
11 Reads

Corrigendum.

Authors:

Acta Neurol Scand 2019 Mar 8;139(3):313. Epub 2019 Feb 8.

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http://dx.doi.org/10.1111/ane.13066DOI Listing

Optic nerve ultrasound measurement in multiple sclerosis.

Acta Neurol Scand 2019 Apr 18;139(4):399-400. Epub 2019 Feb 18.

Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1111/ane.13072DOI Listing
April 2019
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Depression and risk of cognitive dysfunctions in amyotrophic lateral sclerosis.

Acta Neurol Scand 2019 May 28;139(5):438-445. Epub 2019 Feb 28.

Department of Neurology, Maggiore della Carità Hospital, University of Piemonte Orientale, Novara, Italy.

Objectives: Amyotrophic lateral sclerosis (ALS) is not only a motor disorder: More than 50% of patients have cognitive dysfunctions over the course of the disease. At the same time, mood disorders may also occur in ALS patients following diagnosis due to the fatal prognosis; however, little data are available on any depression beforehand. Starting from these considerations, the aim of our study was to investigate the occurrence of depression in Italian ALS patients prior to diagnosis, evaluating its prevalence in the subjects who have developed cognitive dysfunctions and in those who did not. Read More

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http://doi.wiley.com/10.1111/ane.13073
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http://dx.doi.org/10.1111/ane.13073DOI Listing
May 2019
15 Reads

Therapeutic drug monitoring of gabapentin in various indications.

Acta Neurol Scand 2019 May 19;139(5):446-454. Epub 2019 Feb 19.

Department of Pharmacology, Oslo University Hospital, Oslo, Norway.

Objectives: Gabapentin has been increasingly used in various indications in recent years. Despite variable pharmacokinetics, therapeutic drug monitoring (TDM) is scarcely described in other indications than epilepsy. The aim of the study was to investigate the use and pharmacokinetic variability of gabapentin in epilepsy and non-epilepsy indications and to further evaluate the use of TDM in patients with restless legs syndrome (RLS). Read More

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http://dx.doi.org/10.1111/ane.13075DOI Listing
May 2019
2 Reads

Treatment of medication overuse headache-A review.

Acta Neurol Scand 2019 May 8;139(5):405-414. Epub 2019 Mar 8.

Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Glostrup, Denmark.

Medication overuse headache (MOH) is the most prevalent chronic headache disorder with a prevalence between 1% and 2% worldwide. The disease has been acknowledged for almost 30 years, yet experts still disagree on how best to treat MOH. By performing a search in PubMed on the terms "medication overuse headache," "analgesics abuse headache," "rebound headache," "drug induced headache," and "headache AND drug misuse" limited to human studies published in English between January 1, 2004, and November 1, 2017, we aimed to evaluate current literature concerning predictors of treatment outcome, inpatient and outpatient treatment programs, initial versus latent administration of prophylactic medications, and to review the effect of prophylactic medications. Read More

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http://dx.doi.org/10.1111/ane.13074DOI Listing

Autoantibodies in acquired myasthenia gravis: Clinical phenotype and immunological correlation.

Acta Neurol Scand 2019 May 19;139(5):428-437. Epub 2019 Feb 19.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.

Background: Data on antibody profile in myasthenia gravis (MG) from India are limited.

Objectives: To investigate antibody profile in patients with MG and their clinical correlates.

Patients And Methods: Patients of MG (n = 85, M:F::1. Read More

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http://doi.wiley.com/10.1111/ane.13071
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http://dx.doi.org/10.1111/ane.13071DOI Listing
May 2019
7 Reads

A prospective study on gait dominant normal pressure hydrocephalus.

Acta Neurol Scand 2019 Apr 19;139(4):389-394. Epub 2019 Feb 19.

Barrow Neurological Institute, Dignity Health Organization, St. Joseph Hospital and Medical Center, Phoenix, Arizona.

Object: We characterize idiopathic normal pressure hydrocephalus (NPH) following treatment with lumbar puncture (LP) and shunt placement through clinical evaluation and quantitative ProtoKinetics Zeno walkway assessments. We evaluate the symptomology by determining gait characteristics altered by treatment.

Methods: Patients at Barrow Neurological Institute (BNI) who underwent a LP, removing 30-32 mL cerebrospinal fluid) followed by ventriculoperitoneal shunt placement in February 2015 to February 2017 were analyzed for gait impairments. Read More

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http://dx.doi.org/10.1111/ane.13064DOI Listing
April 2019
2 Reads

Work-related predictors for return to work after stroke.

Acta Neurol Scand 2019 Apr 6;139(4):382-388. Epub 2019 Feb 6.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: Disability due to stroke imposes a large burden on individuals, and on society, in terms of impaired work ability and sick leave. The reported return to work (RTW) rate after stroke varies globally and is influenced by a range of different aspects. The aim of this study was to investigate the influence of work-related factors on time to RTW after stroke, and possible differences between the sexes. Read More

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http://dx.doi.org/10.1111/ane.13067DOI Listing

Prognosis for intracerebral hemorrhage during ongoing oral anticoagulant treatment.

Acta Neurol Scand 2019 May 14;139(5):415-421. Epub 2019 Feb 14.

Department of Neurology, Skane University Hospital, Lund University, Lund, Sweden.

Background: Intracerebral hemorrhage (ICH) is the most serious adverse effect of treatment with oral anticoagulants. Prognostic data after ICH associated with non-vitamin K antagonist oral anticoagulants (NOAC) compared to vitamin K antagonists (VKA) are sparse. We compared 90-day survival and functional outcome following NOAC-ICH versus VKA-ICH using data from the Swedish Stroke Register (Riksstroke). Read More

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http://dx.doi.org/10.1111/ane.13068DOI Listing

Cerebrospinal fluid NCAM levels are modulated by disease-modifying therapies.

Acta Neurol Scand 2019 May 5;139(5):422-427. Epub 2019 Mar 5.

Department of Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK.

Background: Little is known about what leads to recovery between relapses in multiple sclerosis (MS), particularly following treatment. In the past, it has been demonstrated that soluble neural cell adhesion molecule (sNCAM), a putative biomarker of neuroplasticity, increased following steroid treatment in the Cerebrospinal fluid (CSF) of MS subjects undergoing acute relapses. Taking this a step further, we have evaluated the effect of disease-modifying treatment (DMTs) on CSF sNCAM levels in various subtypes of MS. Read More

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http://dx.doi.org/10.1111/ane.13069DOI Listing
May 2019
9 Reads

Distribution of migraine attacks over the days of the week: Preliminary results from a web-based questionnaire.

Acta Neurol Scand 2019 Apr 28;139(4):340-345. Epub 2019 Jan 28.

Institute of Information Systems, University of Applied Sciences Hof, Hof, Germany.

Objectives: The purpose of this work is the analysis of migraine attack reports collected online within the project Migraine Radar in respect to the distribution of the migraine attacks over the week on a single-participant level.

Materials & Methods: Recording data using a web app as well as smartphone apps made it possible to collect data of 44 639 migraine attacks of 1085 participants who reported seven or more attacks over a participation period of at least 90 days. This allows the investigation of attack distributions on a single-participant level. Read More

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http://dx.doi.org/10.1111/ane.13065DOI Listing
April 2019
2 Reads

Intravenous metoclopramide in the treatment of acute migraines: A randomized, placebo-controlled trial.

Acta Neurol Scand 2019 Apr 28;139(4):334-339. Epub 2019 Jan 28.

Department of Emergency Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.

Objectives: The present study aimed to evaluate the efficacy and safety of intravenous metoclopramide for acute migraine treatment.

Materials And Methods: A double-blind, randomized, parallel-group, placebo-controlled trial was carried out in an academic emergency department. After the patients were assessed for eligibility via the International Headache Society criteria for migraines, they were randomized into 10 mg intravenous metoclopramide and normal saline groups. Read More

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http://doi.wiley.com/10.1111/ane.13063
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http://dx.doi.org/10.1111/ane.13063DOI Listing
April 2019
2 Reads

Perampanel for treatment of status epilepticus in Austria, Finland, Germany, and Spain.

Acta Neurol Scand 2019 Apr 20;139(4):369-376. Epub 2019 Jan 20.

Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, Goethe University, Frankfurt am Main, Germany.

Objective: Novel treatments are needed to control treatment-resistant status epilepticus (SE). We report a summary of clinical cases where perampanel was used in established SE, refractory SE (RSE), or super-refractory SE (SRSE).

Methods: Medical records were retrospectively reviewed for perampanel administration in SE at five European hospitals between 2011 and 2015. Read More

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http://dx.doi.org/10.1111/ane.13061DOI Listing
April 2019
10 Reads

Carotid artery stenting: Current state of evidence and future directions.

Acta Neurol Scand 2019 Apr 6;139(4):318-333. Epub 2019 Feb 6.

Interventional Radiology Service, Department of Radiology, Austin Hospital, Melbourne, Victoria, Australia.

Both carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for carotid artery stenosis. Several randomized controlled trials (RCTs) have compared CEA to CAS in the treatment of carotid artery stenosis. These studies have suggested that CAS is more strongly associated with periprocedural stroke; however, CEA is more strongly associated with myocardial infarction. Read More

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http://doi.wiley.com/10.1111/ane.13062
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http://dx.doi.org/10.1111/ane.13062DOI Listing
April 2019
6 Reads
2.395 Impact Factor

Hemofiltration for neuroprotection in acute ischemic stroke: A prospective, pilot study.

Acta Neurol Scand 2019 Apr 27;139(4):377-381. Epub 2018 Dec 27.

National Research Oncology and Transplantation Center, Astana, Kazakhstan.

Background: Hemofiltration reduces blood levels of cytokines, glutamate, and other substances that increase the risk of stroke-associated neurodegeneration. This study aimed to assess the safety and efficacy of hemofiltration in acute ischemic stroke patients.

Methods: A total of 37 patients (mean age 56 ± 16 years) who had an ischemic stroke within the previous 12 hours were randomized to receive hemofiltration for 36 hours (n = 19) or standard treatment (n = 18). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13060
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http://dx.doi.org/10.1111/ane.13060DOI Listing
April 2019
8 Reads

BRIVA-LIFE-A multicenter retrospective study of the long-term use of brivaracetam in clinical practice.

Acta Neurol Scand 2019 Apr 27;139(4):360-368. Epub 2018 Dec 27.

Infanta Leonor Hospital, Madrid, Spain.

Objectives: Evaluate long-term effectiveness and tolerability of brivaracetam in clinical practice in patients with focal epilepsy.

Materials And Methods: This was a multicenter retrospective study. Patients aged ≥16 years were started on brivaracetam from November 2016 to June 2017 and followed over 1 year. Read More

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http://dx.doi.org/10.1111/ane.13059DOI Listing
April 2019
6 Reads

Comparison of new-onset and persistent epilepsy in the elderly.

Acta Neurol Scand 2019 Apr 4;139(4):395-398. Epub 2019 Jan 4.

Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.

Background: Previous studies on elderly epilepsy included only patients with new-onset disease, but there are many patients who developed epilepsy earlier and aged.

Aim: We compared the characteristics of new-onset and persistent epilepsy in the elderly.

Methods: We performed a 10-year retrospective analysis of elderly patients with epilepsy divided into two groups according to the onset of seizure: new-onset epilepsy (onset age ≥65) and persistent epilepsy (onset age<65). Read More

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http://dx.doi.org/10.1111/ane.13058DOI Listing
April 2019
5 Reads
2.395 Impact Factor

Multiple sclerosis epidemiology in Finland: Regional differences and high incidence.

Acta Neurol Scand 2019 Apr 3;139(4):353-359. Epub 2019 Jan 3.

Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.

Objectives: Studies on the east-west gradient of multiple sclerosis (MS) are scarce. In Finland, epidemiological differences have been only partially elucidated, but the MS risk is high, and it has been claimed that the occurrence follows a longitudinal gradient. In this register-based study, we updated the MS epidemiology in southwest Finland (SwF) and compared it to the easternmost hospital district, North Karelia (NK), for which no previous data exist. Read More

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http://doi.wiley.com/10.1111/ane.13057
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http://dx.doi.org/10.1111/ane.13057DOI Listing
April 2019
10 Reads

Circulating nociceptin and CGRP in medication-overuse headache.

Acta Neurol Scand 2019 Mar 11;139(3):269-275. Epub 2018 Dec 11.

Department of Neurology, Rigshospitalet-Glostrup, Danish Headache Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Previous studies found low serum levels of nociceptin in migraine patients but high serum levels of calcitonin gene-related peptide (CGRP). CGRP can elicit migraine-like headache. Medication-Overuse Headache (MOH) often has migraine features and can mimic chronic migraine. Read More

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http://doi.wiley.com/10.1111/ane.13053
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http://dx.doi.org/10.1111/ane.13053DOI Listing
March 2019
17 Reads

Predictors to quality of life improvements after subthalamic stimulation in Parkinson's disease.

Acta Neurol Scand 2019 Apr 13;139(4):346-352. Epub 2018 Dec 13.

Department of Neurology & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Introduction: Subthalamic deep brain stimulation (STN DBS) has been reported to improve the quality of life (QoL) related to Parkinson's disease (PD). However, not all subjects are satisfied with the postsurgical QoL outcome. We aimed to detect the related factors and possible predictors to QoL improvement for those PD patients one year after STN DBS. Read More

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http://dx.doi.org/10.1111/ane.13056DOI Listing