8,754 results match your criteria Acta neurologica Scandinavica[Journal]


Interaction between SNCA gene polymorphisms and T2DM with Parkinson's Disease.

Acta Neurol Scand 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, PLA 960 Hospital, Zibo, Shandong, 255300, China.

Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within alpha-synuclein (SNCA) gene, and additional gene- environment interaction with Parkinson's disease (PD) risk.

Methods: Hardy-Weinberg equilibrium (HWE) is tested for controls using SNPstats (http://bioinfo.iconcologia. Read More

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http://dx.doi.org/10.1111/ane.13292DOI Listing

Efficacy and safety of rituximab in autoimmune encephalitis: a meta-analysis.

Acta Neurol Scand 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine, Kathmandu, Nepal.

Background: Autoimmune Encephalitis (AE) is a rare but debilitating neurological disease where the body develops antibodies against neuronal cell surface/synaptic proteins. Rituximab is an anti-CD20 chimeric monoclonal antibody which shows promise in AE treatment observational studies. To our knowledge, there has been no previous meta-analysis providing robust evidence on the effectiveness and safety of rituximab as second-line therapy for the treatment for AE. Read More

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http://dx.doi.org/10.1111/ane.13291DOI Listing

Non-motor symptoms are associated with midline tremor in essential tremor.

Acta Neurol Scand 2020 Jun 1. Epub 2020 Jun 1.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P.R. China.

Objectives: Essential tremor (ET) patients presenting tremor in the midline structures may be a distinct subtype of the syndrome. Therefore, we sought to explore the clinical manifestations, especially non-motor symptoms (NMS) of Chinese ET patients with midline tremor (MT).

Methods: In the cross-sectional study, we grouped 290 definite or probable ET patients based on their MT conditions. Read More

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http://dx.doi.org/10.1111/ane.13290DOI Listing

Neurophysiological impairments in multiple sclerosis - central and peripheral motor pathways.

Acta Neurol Scand 2020 May 31. Epub 2020 May 31.

Exercise Biology, Department of Public Health, Aarhus University, 8000, Aarhus C, Denmark.

A systematic review of literature was conducted comparing neurophysiological outcomes in persons with multiple sclerosis (PwMS) to healthy controls (HC), with studies of central nervous system (CNS) function comprising motor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS), and studies of peripheral nervous system (PNS) function comprising electroneuronography (ENG) outcomes elicited by peripheral nerve stimulation. Studies comparing neuromuscular function, assessed during maximal voluntary contraction (MVC) of muscle, were included if they reported muscle strength along with muscle activation by use of electromyography (EMG) and/or interpolated twitch technique (ITT). Studies of CNS function showed prolonged central motor conduction times, asymmetry of nerve conduction motor pathways and prolonged latencies in PwMS when compared to HC. Read More

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http://dx.doi.org/10.1111/ane.13289DOI Listing

Subjective postural vertical in Parkinson's disease with lateral trunk flexion.

Acta Neurol Scand 2020 May 21. Epub 2020 May 21.

Department of Neurology, Noborito Neurology Clinic, Kawasaki, Kanagawa, Japan.

Background: Patients with Parkinson's disease (PD) and associated lateral trunk flexion (LTF) cannot accurately perceive their own verticality.

Objective: We measured the subjective postural vertical in coronal plane (SPVc) angle on patients' ipsilateral, contralateral sides and combined to clarify the effects of SPVc on LTF. We also investigated effects of the SPVc angle on LTF severity. Read More

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http://dx.doi.org/10.1111/ane.13285DOI Listing

Associations between MRI and EMG findings in myopathies.

Acta Neurol Scand 2020 May 20. Epub 2020 May 20.

Department of Diagnostic and Interventional Radiology, University of Magdeburg, Magdeburg, Germany.

Objectives: Magnetic resonance imaging (MRI) is a cornerstone in diagnosis of myopathies. The present study sought to elucidate possible associations between electromyography (EMG) findings and histogram parameters derived from clinical MRI in myositis and other myopathies.

Materials & Methods: 26 patients with myopathies were included in this retrospective study. Read More

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http://dx.doi.org/10.1111/ane.13284DOI Listing

Up-regulated serum miR-128-3p in progressive and relapse-free multiple sclerosis patients.

Acta Neurol Scand 2020 May 20. Epub 2020 May 20.

Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona - Neurology Section, Verona, Italy.

Background: Circulating microRNAs have emerged as novel multiple sclerosis (MS) biomarkers.

Aims: To assess the association between candidate miRs expression in serum samples of patients with MS and the disease course.

Methods: Serum levels of ten microRNAs (i. Read More

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http://dx.doi.org/10.1111/ane.13288DOI Listing

Time course of 75%-100% efficacy response of adjunctive brivaracetam.

Acta Neurol Scand 2020 May 20. Epub 2020 May 20.

UCB Pharma, Smyrna, GA, USA.

Background: Time to sustained seizure frequency reduction can provide clinically meaningful epilepsy outcomes.

Aims Of The Study: Examine the time course of brivaracetam (BRV) efficacy in adults with focal seizures and focal to bilateral tonic-clonic seizures (FBTCS).

Methods: Post hoc analysis of data pooled from three randomized controlled trials of oral adjunctive BRV in adults with epilepsy. Read More

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http://dx.doi.org/10.1111/ane.13287DOI Listing

Changes in perampanel levels during de-induction: Simulations following carbamazepine discontinuation.

Acta Neurol Scand 2020 May 20. Epub 2020 May 20.

Eisai Ltd, Hatfield, Hertfordshire, UK.

Objective: To evaluate the time course of changes in perampanel levels when co-administered with carbamazepine, and following carbamazepine discontinuation, using a physiologically based pharmacokinetic (PBPK) model.

Methods: The PBPK model was developed, verified using clinical PK data, and used to simulate the effect of abrupt discontinuation and down-titration (75 mg twice daily [bid]/week) of co-administered carbamazepine 300 mg bid on the PK of perampanel once daily (qd). Perampanel dose tapering (8-4 mg) and up-titration (2-6 mg) was simulated during abrupt carbamazepine 300 mg bid discontinuation to identify a titration schedule that minimizes changes in perampanel plasma concentrations. Read More

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http://dx.doi.org/10.1111/ane.13286DOI Listing

Retinal thinning and brain atrophy in early MS and CIS.

Acta Neurol Scand 2020 May 16. Epub 2020 May 16.

Division of Neurology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.

Background: Optical coherence tomography (OCT) could be complementary to magnetic resonance imaging (MRI) of the brain in monitoring course of multiple sclerosis (MS) and clinically isolated syndrome (CIS). Thinning of neurons in ganglion cell-inner plexiform layer (GCIPL) measured by OCT is assumed to be associated with brain atrophy.

Objectives: To evaluate association of GCIPL with brain parameters detected by quantitative MRI (qMRI) and MR-spectroscopy (MRS) in early MS and CIS. Read More

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http://dx.doi.org/10.1111/ane.13282DOI Listing

Clinical characteristics of GAD 65 associated autoimmune encephalitis.

Acta Neurol Scand 2020 May 16. Epub 2020 May 16.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, P.R. China.

Objectives: To examine the clinical characteristics of autoimmune encephalitis associated with the glutamate decarboxylase 65 (GAD 65) antibody.

Materials And Methods: Medical records of all patients that diagnosed with GAD65 antibody-associated encephalitis were retrospectively analyzed. Data regarding demographics and symptoms, neurological signs, laboratory and imaging results, treatment and prognosis were collected. Read More

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http://dx.doi.org/10.1111/ane.13281DOI Listing

Intrathecal immunoreactivity in people with or without previous infectious mononucleosis.

Acta Neurol Scand 2020 May 16. Epub 2020 May 16.

Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: The risk of developing multiple sclerosis (MS) increases (OR: 3.1) after infectious mononucleosis (IM). However, the nature of this link is obscure. Read More

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http://dx.doi.org/10.1111/ane.13280DOI Listing

DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients.

Acta Neurol Scand 2020 May 16. Epub 2020 May 16.

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, Rome, Italy.

Objectives: The involvement of epigenetics mechanisms in the transcriptional regulation of key genes has been investigated in the initiation and progression of neurodegenerative disorders, including Parkinson's disease (PD). Among others, we here focused the attention on the dopamine transporter (DAT) gene playing a critical role in maintaining the integrity of dopaminergic neurons.

Materials And Methods: We performed bisulfite pyrosequencing to examine DNA methylation levels of six CpG sites in the 5'-UTR of DAT1 gene in human peripheral blood mononuclear cells (PBMCs) obtained from 101 sporadic PD patients and 59 healthy controls. Read More

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http://dx.doi.org/10.1111/ane.13279DOI Listing

Neurological Manifestations of COVID-19: A systematic review and current update.

Acta Neurol Scand 2020 May 15. Epub 2020 May 15.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest, Liverpool, UK.

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in December of 2019 in the city of Wuhan, China. Since the outbreak, various reports detail its symptoms and outcomes, primarily focusing on respiratory complications. However, reports are emerging of the virus' effects systemically, including that of the nervous system. Read More

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http://dx.doi.org/10.1111/ane.13266DOI Listing

EEG patterns associated with present cortical SSEP after cardiac arrest.

Acta Neurol Scand 2020 May 11. Epub 2020 May 11.

Department of Neurology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.

Background: After cardiac arrest (CA), present cortical somatosensory evoked potentials (N20 response of SSEPs) have low predictive value for good outcome and might be redundant with EEG.

Aims: To determine whether specific features, or rather global, standardized EEG assessments, are reliably associated with cortical SSEP occurrence after cardiac arrest (CA).

Methods: In a prospective CA registry, EEGs recorded within 72 hours were scored according to the ACNS nomenclature, and also categorized into "benign," "malignant," and "highly malignant. Read More

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http://dx.doi.org/10.1111/ane.13264DOI Listing

Subjective health complaints and exposure to tick-borne infections in southern Norway.

Acta Neurol Scand 2020 May 11. Epub 2020 May 11.

Department of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway.

Objectives: Whether tick-borne infections can cause chronic subjective health complaints is heavily debated. If such a causal connection exists, one would expect to find more health complaints among individuals exposed to tick-borne infections than among non-exposed. In this study, we aimed to assess if exposure to tick-borne infections earlier in life, evaluated by examination of serum for IgG antibodies to tick-borne microbes, was associated with self-reported somatic symptom load. Read More

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http://dx.doi.org/10.1111/ane.13263DOI Listing

Epidemiology of multiple sclerosis in Santiago de Compostela (Spain).

Acta Neurol Scand 2020 May 11. Epub 2020 May 11.

Neurology Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.

Objectives: To analyze the frequency and demographic characteristics of multiple sclerosis (MS) in the Council of Santiago de Compostela (SPAIN).

Material And Methods: The patients diagnosed with MS according to the McDonald 2010 diagnostic criteria were identified within the population of the District of Santiago de Compostela. Several sources were used (records and databases from Hospital, General Practitioners, Private Clinics, and the MS Patients Association). Read More

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http://dx.doi.org/10.1111/ane.13265DOI Listing

Personality disorders in temporal lobe epilepsy: What do they signify?

Acta Neurol Scand 2020 May 9. Epub 2020 May 9.

R.Madhavan Nayar Center for Comprehensive Epilepsy Care, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.

Objectives: To estimate the prevalence of personality disorders in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and compare it with general population and analyze their implications on treatment outcome.

Materials And Methods: TLE was diagnosed based on clinical history, MRI, and Video EEG data. IPDE-ICD10 screening questionnaire was applied to investigate personality disorder in 120 subjects, 60 cases, and 60 normal controls. Read More

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http://dx.doi.org/10.1111/ane.13259DOI Listing

European perspective of perampanel response in people with Intellectual Disability.

Acta Neurol Scand 2020 May 8. Epub 2020 May 8.

Cornwall Partnership NHS Foundation Trust, Redruth, UK.

Background: Epilepsy prevalence is over 20% for those with ID. It is difficult to diagnose and treat and more likely to be treatment resistant. The evidence informing prescribing is sparse, particularly for new drugs such as perampanel (PMP). Read More

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http://dx.doi.org/10.1111/ane.13261DOI Listing
May 2020
2.395 Impact Factor

Levodopa infusion in Parkinson's disease: Individual quality of life.

Acta Neurol Scand 2020 May 7. Epub 2020 May 7.

Department of Neurology, Hospital Bremerhaven Reinkenheide, Bremerhaven, Germany.

Objectives: Parkinson's disease (PD) features both motor and non-motor symptoms that substantially impact quality of life (QoL). Levodopa-carbidopa intestinal gel (LCIG) reduces motor complications and improves some non-motor symptoms in advanced PD (APD). Change in patients' health-related quality of life (hrQoL) is a common endpoint in PD trials and has become an important factor in judging overall effect of LCIG. Read More

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http://dx.doi.org/10.1111/ane.13260DOI Listing

Self-limited focal epilepsy decreased regional brain activity in sensorimotor areas.

Acta Neurol Scand 2020 May 3. Epub 2020 May 3.

Department of radiology, the second affiliated hospital of Bengbu Medical College, Bengbu, 233030, Anhui province, China.

Objective: The fractional amplitude of low-frequency fluctuation (fALFF) method was used to identify the regional brain activity deficits of Self-limited focal epilepsy with centrotemporal spikes (SLFECS) relative to normal controls (NCs).

Methods: Total of twenty-one SLFECS (10 females, 11 males; mean age, 8.57 ± 1. Read More

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http://dx.doi.org/10.1111/ane.13258DOI Listing

Physical activity and cognition in young-onset Parkinson's disease.

Acta Neurol Scand 2020 Apr 30. Epub 2020 Apr 30.

School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia.

Background: A relationship has been observed between physical activity and cognition in older-onset Parkinson's disease, as well as improvements in cognition after a physical activity intervention. To date, this has not been investigated in young-onset Parkinson's disease (YOPD).

Objectives: To examine the baseline relationship between physical activity and cognition in YOPD; and to examine whether a physical activity intervention can improve cognition in YOPD. Read More

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http://dx.doi.org/10.1111/ane.13256DOI Listing

Seizure freedom as an outcome in epilepsy treatment clinical trials.

Acta Neurol Scand 2020 Apr 30. Epub 2020 Apr 30.

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

Seizure freedom is recognized as the goal of epilepsy treatment by patients, families, and in treatment guidelines and is associated with notably improved quality of life. However, many studies of epilepsy treatments (including antiseizure medications/antiepileptic drugs, neurostimulation, and dietary therapies) fail to report data on seizure freedom. Even among studies that include this outcome, methods for defining and analyzing seizure freedom vary considerably. Read More

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http://dx.doi.org/10.1111/ane.13257DOI Listing

A meta-analysis of collateral status and outcomes of mechanical thrombectomy.

Acta Neurol Scand 2020 Apr 28. Epub 2020 Apr 28.

Department of Neurology, Cerebrovascular Disease Center, People's Hospital, China Medical University, Shenyang, China.

Objectives: To perform a systematic review and meta-analysis to investigate pretreatment collaterals and outcomes of mechanical thrombectomy in patients with acute ischemic stroke of large-vessel occlusion in anterior circulation.

Methods: We systematically searched Embase, PubMed, and the Cochrane Library from their dates of inception to March 5, 2020, and also manually searched reference lists of relevant articles. Pooled relative risk with 95% confidence interval on the association between good collaterals and functional independence (in terms of mRS 0-2), symptomatic intracranial hemorrhage, mortality, and successful reperfusion were synthesized using a random-effects model. Read More

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http://dx.doi.org/10.1111/ane.13255DOI Listing

Prevalence and risk of thyroid diseases in myasthenia gravis.

Acta Neurol Scand 2020 Apr 23. Epub 2020 Apr 23.

Division of Paediatric Neurology, Chang Gung Memorial Hospital and Chang Gung Children's Hospital, Linko Branch, Taoyuan, Taiwan.

Objectives: To estimate the prevalence of thyroid diseases and the cumulative risk of thyroid diseases during a follow-up period after myasthenia gravis (MG) diagnosis compared with non-MG controls.

Materials And Methods: We used the Taiwan National Health Insurance Database linked to Registry of Catastrophic Illness database to identify patients with MG. The controls were composed of those who did not have MG and were matched with the MG patients by sex, age, and the index date. Read More

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http://dx.doi.org/10.1111/ane.13254DOI Listing

Plantar stimulation alters brain connectivity in idiopathic Parkinson's disease.

Acta Neurol Scand 2020 Apr 16. Epub 2020 Apr 16.

Department of Physiotherapy, Universidade Federal de São Carlos (UFSCAR), São Carlos, Brazil.

Objective: Individuals with Parkinson's disease (PD) and freezing of gait (FOG) present peripheral and central sensitivity disturbances that impair motor performance. This study aimed to investigate long-term effects of plantar sensory stimulation on brain activity, brain connectivity, and gait velocity of individuals with PD and FOG.

Methods: Twenty-five participants were enrolled in this clinical trial (NCT02594540). Read More

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http://dx.doi.org/10.1111/ane.13253DOI Listing

Endovascular thrombectomy at low-volume centres: A Bayesian solution.

Acta Neurol Scand 2020 Apr 13. Epub 2020 Apr 13.

Department of Neurology, Stavanger University Hospital, Stavanger, Norway.

Purpose: Endovascular treatment (EVT) is traditionally performed by neurointerventional radiologists at tertiary medical centres imposing long transport ways to large vessel occlusion (LVO) stroke patients in rural areas. The purpose of this study is to evaluate the technical and clinical results over time at Stavanger University Hospital, a hospital without neurointerventional expertise, where trained general interventional radiologist performs EVT.

Methods: All patients with LVO stroke treated with EVT from May 2009 to December 2018 were included in the analysis. Read More

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http://dx.doi.org/10.1111/ane.13252DOI Listing

Pyridoxine, folate and cobalamin for migraine: A systematic review.

Acta Neurol Scand 2020 Apr 12. Epub 2020 Apr 12.

Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.

There is a possible relationship between migraine and hypercoagulability inducing factors, such as hyperhomocysteinemia. In this context, homocysteine (Hcy)-lowering vitamins (B6-folate-B12) may prove beneficial in the management-prophylaxis of migraine. We performed a systematic literature search in order to retrieve studies assessing the supplementation of B6, folate and B12 (alone or as adjunctive therapies) to migraine patients, as well as patients suffering from other primary headache disorders. Read More

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http://dx.doi.org/10.1111/ane.13251DOI Listing

Drug treatments in patients with cardiac diseases and epilepsy.

Acta Neurol Scand 2020 Apr 7. Epub 2020 Apr 7.

Science of Health Department, School of Medicine, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.

Objective: Comorbidity between epilepsy and heart diseases is frequent.

Methods: All drugs classified within the group of drugs for cardiovascular system according to the Anatomical Therapeutic Chemical (ATC) classification system were reviewed for their effects on seizures or epilepsy.

Results: Several agents showed antiseizure properties in animal models of seizures and/or in patients with epilepsy and only few were proconvulsant. Read More

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http://dx.doi.org/10.1111/ane.13249DOI Listing

Step-rate threshold for physical activity intensity in Parkinson's disease.

Acta Neurol Scand 2020 Apr 7. Epub 2020 Apr 7.

Department of Physical Therapy, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.

Objectives: To examine the relationship between step-rate and energy expenditure during treadmill walking in persons with PD and then further develop a step-rate cut-point for moderate-to-vigorous physical activity (MVPA) for persons with PD.

Materials And Methods: The sample consisted of 30 persons with mild-to-moderate PD and 30 controls matched by age and sex. Participants performed a 6-minute bout of over-ground walking at comfortable speed, and then completed three, 6-minute bouts of treadmill walking at 13. Read More

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http://dx.doi.org/10.1111/ane.13250DOI Listing

The evidence for switching dibenzazepines in people with epilepsy.

Acta Neurol Scand 2020 Apr 6. Epub 2020 Apr 6.

Cornwall Partnership NHS Foundation Trust, Threemilestone Industrial Estate, Truro, UK.

The dibenzazepines particularly carbamazepine are associated with known adverse effects (AEs) and drug to drug interactions. Eslicarbazepine acetate (ESL) is structurally distinct from other members of the dibenzazepine family and has the advantage of once daily dosing. Observational and trial data report successful switching from older dibenzazepines to ESL. Read More

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http://dx.doi.org/10.1111/ane.13248DOI Listing
April 2020
2.395 Impact Factor

Epilepsy treatment gap in Sub-Saharan Africa: Meta-analysis of community-based studies.

Acta Neurol Scand 2020 Mar 27. Epub 2020 Mar 27.

Departments of Medicine, Bayero University, Kano, Nigeria.

Objective: To evaluate the prevalence, highlight the variation and determine the trend over time, of epilepsy treatment gap (ETG) in Sub-Saharan Africa (SSA).

Methods: We systematically searched PubMed, MEDLINE, Embase, ISI databases, and African Journal Online (AJOL). We determined the pooled prevalence estimate of ETG and the degree of heterogeneity in the region. Read More

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http://dx.doi.org/10.1111/ane.13246DOI Listing

EEG and Coma Recovery Scale-Revised prediction of neurological outcome in Disorder of Consciousness patients.

Acta Neurol Scand 2020 Mar 27. Epub 2020 Mar 27.

IRCCS Fondazione Don Carlo Gnocchi, Firenze, Italy.

Objective: According to electroencephalogram (EEG) descriptors included in the American Clinical Neurophysiology Society (ACNS) terminology, we generated a score, and we compared it to the EEG scores previously proposed in order to identify the one with the best prognostic power for neurological outcome at post-acute stages in patients with severe disorders of consciousness (DoC).

Materials And Methods: Patients included in the analysis were clinically evaluated with the Coma Recovery Scale-Revised (CRS-R). An EEG was performed within the first week after admission to Intensive Rehabilitation Unit (IRU). Read More

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http://dx.doi.org/10.1111/ane.13247DOI Listing

Phenomenology of glioma resection in the dorsal medial frontal cortex.

Acta Neurol Scand 2020 Mar 21. Epub 2020 Mar 21.

Department of Clinical Sciences: Neuroscience, Umeå University, Umeå, Sweden.

Background: During the latest decades, the hypothesis that the subjective experience of free will is determined by preconscious activity in the dominant dorsal medial frontal cortex (dMFC) has repeatedly challenged our commonly held concepts of moral responsibility.

Aims Of The Study: To investigate whether dMFC activity determines the sense of free will and to investigate the effects of resections in this area on quality of life (QoL).

Methods: A cohort of nine patients affected by transient declines in speech and movement skills after surgery involving the left dMFC answered questions about their post-operative, subjective experiences of volition in relation to symptoms. Read More

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http://dx.doi.org/10.1111/ane.13245DOI Listing

The impact of social capital on patients with multiple sclerosis.

Acta Neurol Scand 2020 Mar 18. Epub 2020 Mar 18.

Barts and The London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK.

Objective: To evaluate the association between social capital (SC) and the physical and psychological impact of multiple sclerosis (MS).

Materials & Methods: A cross-sectional study was conducted among people with MS (pwMS) at The Royal London Hospital, London, UK. Participants completed a survey including the Multiple Sclerosis Impact Scale-29 (MSIS-29), the Hospital Anxiety and Depression Scale (HADS), the self-reported EDSS and a SC questionnaire (SCQ). Read More

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http://dx.doi.org/10.1111/ane.13244DOI Listing

Trigeminal neuralgia in multiple sclerosis: Prevalence and association with demyelination.

Acta Neurol Scand 2020 Mar 18. Epub 2020 Mar 18.

Department of Neurosciences, University of Helsinki, Helsinki, Finland.

Objectives: The association of trigeminal neuralgia (TN) with multiple sclerosis (MS) is still widely unaddressed in larger, systematical clinical series. In this study, a cohort of Finnish MS patients was assessed regarding the incidence and prevalence of TN, as well as the presence of demyelinating lesions near the trigeminal ganglion, thus searching for a causative role of MS plaques in TN onset.

Materials & Methods: All consecutive patients treated and followed up for MS (ICD-code G35) in Helsinki University Hospital during 2004-2017 were identified from the Finnish MS register. Read More

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http://dx.doi.org/10.1111/ane.13243DOI Listing

Distinct non-motor features of essential tremor with head tremor patients.

Acta Neurol Scand 2020 Mar 16. Epub 2020 Mar 16.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Background: There have been few comprehensive scale studies on the non-motor symptoms (NMS) of patients with essential tremor (ET) with head tremor (ETh) and those with ET without head tremor (ETol). We aimed to explore the motor symptoms and NMS of these two subgroups.

Methods: We enrolled 199 patients with ET (125, ETol; 74 ETh) and 132 healthy controls. Read More

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http://dx.doi.org/10.1111/ane.13242DOI Listing

Clinical features and outcomes of benign recurrent vertigo.

Acta Neurol Scand 2020 Mar 13. Epub 2020 Mar 13.

Department of ORL, Gelre Hospital Apeldoorn, Apeldoorn, The Netherlands.

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http://dx.doi.org/10.1111/ane.13241DOI Listing

Reply to: "Clinical features and outcomes of benign recurrent vertigo".

Acta Neurol Scand 2020 Mar 13. Epub 2020 Mar 13.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

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http://dx.doi.org/10.1111/ane.13240DOI Listing

Incidence of AChR Ab-positive myasthenia gravis in Israel: A population-based study.

Acta Neurol Scand 2020 Mar 7. Epub 2020 Mar 7.

Department of Neurology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.

Background: The incidence of myasthenia gravis (MG) has traditionally been low, ranging between 2-6/10 . Several recent epidemiological studies have reported a higher incidence. We, therefore, aimed to assess and characterize the incidence of MG in Israel. Read More

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http://dx.doi.org/10.1111/ane.13239DOI Listing

Reply to: Amyotrophic Lateral Sclerosis with depression, cognitive impairment and mortality.

Acta Neurol Scand 2020 Mar 2. Epub 2020 Mar 2.

Department of Neurology and ALS Centre, University of Piemonte Orientale, Maggiore della Carità Hospital, Novara, Italy.

First, we read with interest and we thank Dr. Tomoyuki Kawada for his thoughtful letter (1) about our recent paper titled "Depression and risk of Cognitive Dysfunctions in Amyotrophic Lateral Sclerosis". Read More

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http://dx.doi.org/10.1111/ane.13238DOI Listing

Amyotrophic lateral sclerosis with depression, cognitive impairment, and mortality.

Authors:
Tomoyuki Kawada

Acta Neurol Scand 2020 Mar 3. Epub 2020 Mar 3.

Department of Hygiene and Public Health, Nippon Medical School, Bunkyo-Ku, Japan.

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http://dx.doi.org/10.1111/ane.13237DOI Listing

Psychological factors associated with self-management in multiple sclerosis.

Acta Neurol Scand 2020 Mar 2. Epub 2020 Mar 2.

Department of Adapted Physical Activity, Poznań University of Physical Education, Poznan, Poland.

Objective: Patient's engagement in their own treatment has been shown to improve clinical outcomes. A better understanding of the association between self-management in multiple sclerosis (MS) and potentially modifiable psychological factors may provide clinicians with strategies to design and stimulate better patient activation for self-managing health. Therefore, in this study, we examined whether cognitive factors, namely self-efficacy, acceptance of illness, optimism, and health locus of control (HLC), are associated with self-management in MS. Read More

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http://dx.doi.org/10.1111/ane.13236DOI Listing

Air pollution, a risk factor for multiple sclerosis?

Acta Neurol Scand 2020 Feb 25. Epub 2020 Feb 25.

Department of Political and Social Sciences, University of Trieste, Trieste, Italy.

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http://dx.doi.org/10.1111/ane.13235DOI Listing
February 2020

Lifetime risk of stroke in the general male population.

Acta Neurol Scand 2020 Feb 23. Epub 2020 Feb 23.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: Most previous studies of incidence rates of stroke are from register studies, while data from prospective cohort studies are limited. The aim of the present study was to describe hazard rates, prevalence and cumulative proportion free from stroke during a lifelong follow-up of a representative sample of middle-aged men sampled from the general population.

Methods: A population-based sample of 855 men, all born in 1913, was investigated at 50 years of age and followed up with repeated medical examinations at age 54, 60, 67, 75 and 80. Read More

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http://dx.doi.org/10.1111/ane.13234DOI Listing
February 2020

Vision-related quality of life in patients with occipital stroke.

Acta Neurol Scand 2020 Jun 18;141(6):509-518. Epub 2020 Mar 18.

Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Objectives: The aim of this study was to detect visual field defects (VFDs) after occipital infarction, investigate the rate of recovery and the impact of VFD upon vision-related quality of life (QoL).

Materials And Methods: Multicenter, prospective study including patients with MRI verified acute occipital infarction (NOR-OCCIP project). Ophthalmological examination including perimetry was performed within 2 weeks and after 6 months. Read More

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http://dx.doi.org/10.1111/ane.13232DOI Listing

Direct visual targeting versus preset coordinates for ANT-DBS in epilepsy.

Acta Neurol Scand 2020 Feb 20. Epub 2020 Feb 20.

Department of Neurology, Oslo University Hospital, Oslo, Norway.

Objectives: Deep brain stimulation (DBS) of the anterior thalamic nucleus (ANT) may be used against refractory focal epilepsy, but only two randomized double-blinded trials have been performed. The Oslo study was discontinued prematurely since reduction in seizure frequency was less than expected. The aim of the present study was to review the targeting used in the Oslo study and to identify the actual positions of the contacts used for stimulation. Read More

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http://dx.doi.org/10.1111/ane.13233DOI Listing
February 2020

Valproate risk form-Surveying 215 clinicians involving 4775 encounters.

Acta Neurol Scand 2020 Jun 10;141(6):483-490. Epub 2020 Mar 10.

Cornwall Partnership NHS Foundation Trust, Truro, UK.

Objectives: Annual completion of a Valproate Risk Acknowledgement Form (RAF) is mandated in the United Kingdom due to neurodevelopmental risks of in utero valproate exposure. The number of women of childbearing potential taking valproate, the uptake of the RAF within this population and their clinical outcomes is not known or monitored. This study surveyed responses of clinicians administering the RAF to women of childbearing potential taking valproate medications. Read More

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http://dx.doi.org/10.1111/ane.13231DOI Listing
June 2020
2.395 Impact Factor

Lacosamide in patients with epilepsy of cerebrovascular etiology.

Acta Neurol Scand 2020 Jun 13;141(6):473-482. Epub 2020 Mar 13.

University of Eastern Finland and Kuopio Epilepsy Centre, Kuopio University Hospital, Kuopio, Finland.

Objectives: To assess tolerability and efficacy of lacosamide in adults with cerebrovascular epilepsy etiology (CVEE).

Materials And Methods: Exploratory post hoc analyses of a double-blind, initial monotherapy trial of lacosamide vs carbamazepine-controlled release (carbamazepine-CR) (SP0993; NCT01243177); a double-blind conversion to lacosamide monotherapy trial (SP0902; NCT00520741); and an observational study of adjunctive lacosamide added to one antiepileptic drug (SP0973 VITOBA; NCT01098162). Patients with CVEE were identified based on epilepsy etiology recorded at baseline. Read More

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http://dx.doi.org/10.1111/ane.13230DOI Listing

Outcomes of stereoelectroencephalography exploration at an epilepsy surgery center.

Acta Neurol Scand 2020 Jun 9;141(6):463-472. Epub 2020 Mar 9.

Calgary Comprehensive Epilepsy Program, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.

Objectives: Epilepsy surgery is offered in resistant focal epilepsy. Non-invasive investigations like scalp video EEG monitoring (SVEM) help delineate epileptogenic zone. Complex cases may require intracranial video EEG monitoring (IVEM). Read More

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http://dx.doi.org/10.1111/ane.13229DOI Listing
June 2020
2.395 Impact Factor