1,990 results match your criteria Acta neurobiologiae experimentalis[Journal]


Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats.

Acta Neurobiol Exp (Wars) 2018 ;78(4):358-374

Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague, Czech Republic;

Spinal cord injury leads to a robust inflammatory response that is an unfavorable environment for stem cell implantation. In this study, we evaluated the effect of combined therapy of curcumin and mesenchymal stem cells (MSC) on behavioral recovery and tissue sparing, glial scar formation, axonal sprouting and inflammatory responses in a rat experimental model of spinal cord injury (SCI). Balloon-induced compression lesion was performed at thoracic (Th8-9) spinal level. Read More

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January 2018
22 Reads

Neurological improvement in patients with chronic spinal cord injury treated with leuprolide acetate, an agonist of GnRH.

Acta Neurobiol Exp (Wars) 2018 ;78(4):352-357

Laboratory of Neurophysiology, Department of Physiology and Pharmacology, Universidad Autónoma de Aguascalientes, Aguascalientes, México.

It has been reported that gonadotropin‑releasing hormone (GnRH), and its analogue leuprolide acetate (LA), have neurotrophic properties; particularly in the regeneration of injured spinal cord in animal models and in the case of a patient with spinal cord injury (SCI). The aim of this study was to establish whether treatment with LA improves sensitivity, motor activity and independence in patients with chronic SCI. Patients were treated LA once a month for six months. Read More

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January 2018
10 Reads

Calcium release from intracellular stores is involved in mitochondria depolarization after lowering extracellular pH in rat brain synaptosomes.

Acta Neurobiol Exp (Wars) 2018 ;78(4):343-351

Laboratory of Biophysics and Engineering of Cell, Institute of Biophysics and Cell Engineering, Minsk, Belarus;

In the brain, pH can be lowered in both healthy and disease states. Previously, we showed that moderate extracellular acidification (down to pHo 7.0), but not intracellular acidification, leads to mitochondrial depolarization in synaptosomes. Read More

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January 2018
9 Reads

Dopamine D2 receptor blockade differentially affects the light‑adapted turtle and frog electroretinogram.

Acta Neurobiol Exp (Wars) 2018 ;78(4):332-342

Department of Physiology, Medical University of Sofia, Sofia, Bulgaria.

The effects of dopamine D2-class receptor blockade by sulpiride on the electroretinographic (ERG) b-wave (ON response) and d-wave (OFF response) were investigated in light-adapted turtle (Trachemys scripta elegans) and frog (Rana ridibunda) eyecups. For turtle ERG, sulpiride (240 μM) produced an amplitude increase of the b- and d-waves, while the 40 μM and 120 μM of sulpiride were ineffective. Alternatively, for frog ERG, a well-developed and dose-dependent b- and d-wave amplitude decrease was obtained with 40 μM and 240 μM sulpiride. Read More

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January 2018

Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride‑induced experimental Alzheimer's disease.

Acta Neurobiol Exp (Wars) 2018 ;78(4):322-331

Department of Physiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.

Polyphenols and omega‑3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum‑induced Alzheimer's disease model in rats. Read More

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January 2018
14 Reads

Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline.

Acta Neurobiol Exp (Wars) 2018 ;78(4):315-321

Department of Pharmacodynamics, Chair of Pharmacodynamics, Jagiellonian University, Medical College, Cracow, Poland;

Oxaliplatin is a third-generation, platinum-based antitumor drug used to treat colorectal cancer. Since its main adverse effect is neuropathic pain resulting from chemotherapy‑induced peripheral neuropathy (CIPN), this drug is used to study the neurobiology of CIPN in rodents and to search for analgesics that could attenuate neuropathic pain symptoms - cold and tactile allodynia that develop in most of the oxaliplatin‑treated subjects. In this research, testing across various temperatures, we assessed the cold reactivity threshold of albino Swiss mice treated with oxaliplatin. Read More

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January 2018
4 Reads

A relationship between brainstem auditory evoked potential and vagal control of heart rate in adult women.

Acta Neurobiol Exp (Wars) 2018 ;78(4):305-314

Center for the Study of the Autonomic Nervous System (CESNA), Department of Speech-Language Pathology, UNESP, Marília, Brazil;

Numerous studies have investigated the connection between autonomic control of heart rate (HR) and auditory stimulus. Yet, the literature lacks evidence of a close association between auditory brainstem processing and HR autonomic control. We aimed to evaluate and verify the relationship between auditory brainstem response (ABR) and HR variability (HRV) in healthy women. Read More

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January 2018
10 Reads

Lin28 overexpression inhibits neurite outgrowth of primary cortical neurons in vitro.

Acta Neurobiol Exp (Wars) 2018 ;78(4):297-304

Department of Pharmacology, Department of Biomedicine and Health Sciences, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea;

Lin28 has been shown to promote proliferation of progenitors and survival of neurons during cortical neurogenesis. However, the role of Lin28 in the terminal maturation of neurons remains obscured. In this study, we investigated the developmental impact of Lin28 overexpression on neurite outgrowth. Read More

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January 2018
1 Read

c-Fos and neuronal plasticity: the aftermath of Kaczmarek's theory.

Acta Neurobiol Exp (Wars) 2018 ;78(4):287-296

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

The development of molecular biology methods in the early 1980s led to a better understanding of the role of transcription factors in mammalian cells. The discovery that some transcription factors are critically important for cells to switch between different functional states was fundamental for modern molecular neurobiology. In the 1980s Leszek Kaczmarek proposed that, analogically to the cell cycle or to cell differentiation, long‑term synaptic plasticity, learning, and memory should also require the activity of transcription factors. Read More

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January 2018
19 Reads

MMP‑3 deficiency does not influence the length and number of CA1 dendrites of hippocampus of adult mice.

Acta Neurobiol Exp (Wars) 2018 ;78(3):281-286

Laboratory of Cellular Neurobiology, Department of Physiology and Molecular Neurobiology, Wroclaw University, Poland, Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Poland;

Over the past two decades, metalloproteinases (MMPs), including MMP‑2, MMP‑3, and MMP‑9, have been implicated as important players in mechanisms underlying various forms of neuroplasticity. In particular, MMP‑3 was found to be involved in both cognitive functions and in plasticity phenomena, but the underlying molecular mechanisms remain largely elusive. In general, it is believed that functional plasticity of neurons is associated with morphological alterations. Read More

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January 2019
1 Read

The use of MR‑less MNI based neuronavigation for 10 Hz rTMS depression therapy: electrophysiological and clinical implications.

Acta Neurobiol Exp (Wars) 2018 ;78(3):271-280

Republican Vilnius Psychiatric Hospital, Vilnius, Lithuania, Vilnius University, Psychiatry Clinic, Vilnius, Lithuania.

Repetitive transcranial magnetic stimulation (rTMS) is a popular and effective treatment for drug resistant depression. However, there is considerable variability in clinical outcomes, in previous studies and between patients. Because of high requirements for the use of fMRI based neuronavigation, many practitioners of rTMS still choose to use a standard 5 cm rule for rTMS coil placement which leads to large variations in which brain regions are being stimulated. Read More

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January 2019
3 Reads

Testosterone enhancement during pregnancy influences social coping and gene expression of oxytocin and vasopressin in the brain of adult rats.

Acta Neurobiol Exp (Wars) 2018 ;78(3):264-270

Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia.

Steroid hormones are important mediators of prenatal maternal effects and play an important role in fetal programming. The aim of our study was to investigate how testosterone enhancement during pregnancy influences neurobehavioral aspects of social coping of rat offspring in adulthood. Pregnant rat dams were exposed to depot form of testosterone during the last third of pregnancy (i. Read More

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January 2019

Afferent projections of the subthalamic nucleus in the rat: emphasis on bilateral and interhemispheric connections.

Acta Neurobiol Exp (Wars) 2018 ;78(3):251-263

Department of Anatomy, School of Medicine, Koç University, Sarıyer, Istanbul, Turkey.

The subthalamic nucleus (STN) is important for normal movement as well as in movement disorders. The STN is a target nuclei in patients with advanced Parkinson's disease (PD). Deep brain stimulation (DBS) is a standard surgical treatment for PD. Read More

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January 2019
3 Reads

Effects of extensive amygdaloid lesions on conditioned taste aversion in rats.

Acta Neurobiol Exp (Wars) 2018 ;78(3):242-250

Department of Psychobiology, University of Granada, Spain ;

The role of the amygdala in the acquisition of conditioned taste aversion (CTA) is unclear. The lesion studies that have explored specific nuclei of the amygdala point to a probable involvement of the basolateral amygdala, but it remains unclear whether the function of the amygdala in CTA is limited to the activity of the basolateral amygdala. In the current study, extensive bilateral lesions of the amygdala were performed in Wistar rats to explore if the destruction of the amygdala affects the acquisition of CTA, as has been reported with selective lesions of the basolateral amygdala. Read More

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January 2019
2 Reads

Effects of PINK1 mutation on synapses and behavior in the brain of Drosophila melanogaster.

Acta Neurobiol Exp (Wars) 2018 ;78(3):231-241

Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Jagiellonian University, Kraków, Poland;

Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson's disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) and decreased the total locomotor activity during 24 h, in addition to a decrease in climbing ability and a reduced lifespan. Read More

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January 2019
15 Reads

Hindlimb suspension‑induced cell apoptosis in the posterior parietal cortex and lateral geniculate nucleus: corresponding changes in c‑Fos protein and the PI3K/Akt signaling pathway.

Acta Neurobiol Exp (Wars) 2018 ;78(3):220-230

Department of Military Medical Psychology, Fourth Military Medical University, Xian, Shaanxi Provence, China;

Recent physiological studies indicate that weightlessness reliably alters ocular structure and function, as well as the ability to process visual‑spatial information. The posterior parietal cortex (PPC) and lateral geniculate nucleus (LGN) are two key brain areas implicated in the processing of visual‑spatial information. Here, we used the modified tail‑suspension rat model to simulate the physiological effects of microgravity. Read More

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January 2019
4 Reads

The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders.

Acta Neurobiol Exp (Wars) 2018 ;78(3):210-219

Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland;

Synaptic plasticity simply put, is the activity‑dependent modification of the strength or efficacy of synaptic transmission in the network of synapses in the brain. The role of synaptic plasticity in disease is an active area of research. Changes in plasticity translate to the release of neurotransmitters at the synapse and subsequently, the way humans see the world. Read More

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January 2019
1 Read

Charcot‑Marie‑Tooth type 1A drug therapies: role of adenylyl cyclase activity and G‑protein coupled receptors in disease pathomechanism.

Acta Neurobiol Exp (Wars) 2018 ;78(3):198-209

Neuromuscular Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

Charcot‑Marie‑Tooth type 1A (CMT1A) is a dysmyelinating disease of the peripheral nervous system that results in a slow progressive weakening and wasting of the distal muscles of the upper and lower limbs. Despite extensive research and clinical trials there is still no treatment for CMT1A that results in complete neurological improvement. Recent studies investigating various pharmacological modulators of adenylyl cyclase activity, including ascorbic acid and ligands of G protein‑coupled receptors (GPCRs), provide hope for future treatments of this type of hereditary motor and sensory neuropathy. Read More

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January 2019
3 Reads

Role of food‑drug interactions in neurological and psychological diseases.

Acta Neurobiol Exp (Wars) 2018 ;78(3):187-197

Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara,Turkey.

Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food‑drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food‑drug interaction in the treatment of neurological and psychological diseases. Read More

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January 2019
6 Reads

Changes in neurogenesis with post‑hatching age in the male Japanese quail (Cortunix japonica) brain.

Acta Neurobiol Exp (Wars) 2018 ;78(2):173-186

School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South Africa;

Most avian neurogenesis studies have previously focused on the song control system and little attention has been given to non‑song birds. The objective of this study was to assess changes in neurogenesis associated with post‑hatching age (3‑12 weeks) in the Japanese quail brain using proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry. PCNA‑immunoreactive (ir) cells were observed mainly in the olfactory bulb ventricular zone, telencephalic ventricular zones and cerebellum. Read More

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November 2018
3 Reads

The influence of mood on visual perception of neutral material.

Acta Neurobiol Exp (Wars) 2018 ;78(2):163-172

Institute of Psychology, Jagiellonian University, Kraków, Poland.

In the study we investigated how current mood affects spontaneous perceptual processes of neutral stimuli of low‑arousal, unrelated to any specific task. Two separate but similar procedures were carried out: one using functional magnetic resonance imaging (fMRI), the other using electroencephalography based source localization. In both experiments, sessions of passive viewing of neutral pictures were preceded by either a negative or positive mood induction. Read More

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November 2018
1 Read

Summation of two illusions of extent.

Acta Neurobiol Exp (Wars) 2018 ;78(2):148-162

Institute of Research of Biological Systems and Genetics, Lithuanian University of Health Sciences, Kaunas, Lithuania.

In the present visual psychophysical study, the Oppel‑Kundt and and Müller‑Lyer illusion magnitudes were measured separately (by single figures) and in combination (by two patterns superposed spatially). Data for 30 subjects revealed extensive variability both for the separate and combined illusion strength. Nevertheless, the effect of addition of the perceived length distortions was established. Read More

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November 2018
2 Reads

Influence of age on speech intelligibility in babble noise.

Acta Neurobiol Exp (Wars) 2018 ;78(2):140-147

Department of Phoniatrics, First Faculty of Medicine, Charles University and the General University Hospital in Prague, the Czech Republic.

Problems with hearing aids, particularly with regard to speech intelligibility in the presence of noise, are commonly reported by older individuals in everyday practice. The main goal of this study was to measure differences in speech intelligibility between older and younger people and to establish how speech intelligibility in competitive noise differs between younger and older populations with similar hearing status. More than 400 persons were tested using the Czech Test of Sentence Intelligibility in Babble Noise and divided into younger (40-65 years) and older (66-85 years) age groups. Read More

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November 2018
10 Reads

Administration of muscarinic antagonists induce changes in passive avoidance learning and in synaptic transmission in the CA1 area of the hippocampus.

Acta Neurobiol Exp (Wars) 2018 ;78(2):132-139

Neurophysiology of Learning Lab, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Science, Moscow, Russia.

Muscarinic acetylcholine receptors (mAChR) are known to be related to learning and memory processes. Inactivation of mAChR by cholinergic antagonists have been shown to produce amnesia in a variety of behavioral tasks. In this study, we investigated the role of M1 and M2 AChR on passive avoidance learning and plasticity of synapses formed by Schaffer collaterals in freely moving rats. Read More

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November 2018
6 Reads

Face processing in a case of high functioning autism with developmental prosopagnosia.

Acta Neurobiol Exp (Wars) 2018 ;78(2):114-131

Laboratory of Psychophysiology, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Science, Warsaw, Poland.

The ability to "read" the information about facial identity, expressed emotions, and intentions is crucial for non‑verbal social interaction. Neuroimaging and clinical studies consequently link face perception with fusiform gyrus (FG) and occipital face area (OFA) activity. Here we investigated face processing in an adult, patient PK, diagnosed with both high functioning autism spectrum disorder (ASD) and developmental prosopagnosia (DP). Read More

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November 2018
20 Reads

The relationship between alpha burst activity and the default mode network.

Acta Neurobiol Exp (Wars) 2018 ;78(2):92-113

Bioimaging Research Center, World Hearing Center of the Institute of Physiology and Pathology of Hearing, Warsaw/Kajetany, Poland.

Alpha rhythm, described by Hans Berger, is mainly recorded from the occipital cortex (OCC) of relaxed subjects with their eyes closed.Early studies indicated the thalamo‑cortical circuit as the origin of alpha rhythm. Recent works suggest an additional relationship between alpha rhythm and the Default Mode Network (DMN). Read More

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November 2018
1 Read

Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor.

Acta Neurobiol Exp (Wars) 2018 ;78(2):82-91

Department of Movement Physiology, Bogomoletz Institute of Physiology, Kyiv, Ukraine.

We investigated neuronal activation of the rat intermediolateral (IML) nucleus of the thoracolumbar spinal cord, initiated by Achilles tendon vibration, after intramuscular (m. triceps surae) administration of 7‑nitroindazole (7‑NI) or L‑arginine (LA). The spindle afferent response to vibratory stimuli induced a distinct bilateral increase in the activation of c‑Fos immunoreactivity in the spinal neurons in three groups of rats (tendon‑vibrated, tendon‑vibrated + 7‑NI and tendon‑vibrated + LA). Read More

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November 2018
13 Reads
2.244 Impact Factor

The gut microbiota in neuropsychiatric disorders.

Acta Neurobiol Exp (Wars) 2018 ;78(2):69-81

Department of Immunopathology of Infectious and Parasitic Diseases, Medical University of Warsaw, Warsaw, Poland.

The purpose of this review is to summarize current knowledge about the gut microbiota in neuropsychiatric disorders. It is estimated that the human gut is colonized by up to 1018 microorganisms, mostly anaerobic bacteria. The gut microbiome is responsible for multiple functions, e. Read More

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November 2018
1 Read

Effects of postural and cognitive difficulty levels on the standing of healthy young males on an unstable platform.

Acta Neurobiol Exp (Wars) 2018 ;78(1):60-68

Faculty of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran.

Standing on an unstable platform requires continuous effort of the neuro‑musculoskeletal system. The aim of the present study is to evaluate the ability to remain standing on an unstable platform at different levels of postural and cognitive difficulty. Healthy young males stood in the sagittal plane on an unstable platform supported by a pair of springs with modifiable stiffness. Read More

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September 2018
1 Read

Long‑term behavioral, histological, biochemical and hematological evaluations of amyloid beta‑induced Alzheimer's disease in rat.

Acta Neurobiol Exp (Wars) 2018 ;78(1):51-59

Cancer Biology Research Center, Cancer research Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.

Alzheimer's disease (AD) is a mental impairment and neural degeneration which causes progressive loss of memory and cognitive functions. This age‑dependent illness is associated with extracellular amyloid plaques accumulation and twisted neurofibrillary tangles. Amyloid plaques are experimentally generated in animal models in order to investigate the disease process. Read More

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September 2018
1 Read

Possible role of hippocampal GPR55 in spatial learning and memory in rats.

Acta Neurobiol Exp (Wars) 2018 ;78(1):41-50

Grupo de Neurociencias, Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.

Endocannabinoids (eCBs) are involved in the hippocampal mechanisms of spatial learning and memory in rats. Although eCBs exert many of their actions on spatial learning and memory via CB1 receptors, the putative cannabinoid receptor GPR55 (expressed in the hippocampus, cortex, forebrain, cerebellum and striatum) seems to be also involved. To investigate the potential role of GPR55 in spatial learning and memory, Wistar rats received bilateral infusions of lysophosphatidylinositol (LPI, GPR55‑agonist) into the hippocampus 5‑minutes before training‑phase in the Barnes‑maze (BM). Read More

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September 2018

MeCP2 in central nervous system glial cells: current updates.

Acta Neurobiol Exp (Wars) 2018 ;78(1):30-40

Division of Neurobiology, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Gujarat, India.

avMethyl‑CpG binding protein 2 (MeCP2) is an epigenetic regulator, which preferentially binds to methylated CpG dinucleotides in DNA. MeCP2 mutations have been linked to Rett syndrome, a neurodevelopmental disorder characterized by severe intellectual disability in females. Earlier studies indicated that loss of MeCP2 function in neuronal cells was the sole cause of Rett syndrome. Read More

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September 2018
1 Read

Cerebral hypoperfusion in autism spectrum disorder.

Acta Neurobiol Exp (Wars) 2018 ;78(1):21-29

Faculty of Public Health, Inland Norway University of Applied Sciences, Elverum, Norway; Department of Research, Innlandet Hospital Trust, Brumunddal, Norway.

Cerebral hypoperfusion, or insufficient blood flow in the brain, occurs in many areas of the brain in patients diagnosed with autism spectrum disorder (ASD). Hypoperfusion was demonstrated in the brains of individuals with ASD when compared to normal healthy control brains either using positron emission tomography (PET) or single‑photon emission computed tomography (SPECT). The affected areas include, but are not limited to the: prefrontal, frontal, temporal, occipital, and parietal cortices; thalami; basal ganglia; cingulate cortex; caudate nucleus; the limbic system including the hippocampal area; putamen; substantia nigra; cerebellum; and associative cortices. Read More

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September 2018
9 Reads
1 Citation
2.244 Impact Factor

Experimental cerebral hemispherectomy in rodent models. A systematic review of current literature.

Acta Neurobiol Exp (Wars) 2018 ;78(1):14-20

Department of Neurosurgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.

Cerebral hemispherectomy is a neurosurgical procedure that involves surgically removing one hemisphere of the brain, used as a therapeutic option in severe cases of intractable epilepsy. Several animal models have contributed to our understanding of the underlying neuromechanisms. The review was based on a PubMed search using the terms "hemispherectomy" and "mouse" or "rat" or "rodent", with no limitation of year of study or language. Read More

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September 2018
1 Read

A role for the GDAP1 gene in the molecular pathogenesis of Charcot‑Marie‑Tooth disease.

Acta Neurobiol Exp (Wars) 2018 ;78(1):1-13

Neuromuscular Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.

In 2002 a series of mutations in the GDAP1 gene were reported in patients suffering from Charcot‑Marie‑Tooth disease manifesting as early-onset, progressive distal‑muscle wasting and weakness. The molecular etiology of Charcot‑Marie‑Tooth ‑GDAP1 disease has been elucidated but its pathogenesis remains unclear, especially given the seemingly contradictory function of the GDAP1 protein. Expression of GDAP1 is observed almost exclusively in neuronal cells, however, the GDAP1 protein is present in mitochondria, where it plays a role in fission, a ubiquitous process occurring in all cells. Read More

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September 2018
1 Read

Antimuscarinic-induced convulsions in fasted mice after food intake: No evidence of spontaneous seizures, behavioral changes or neuronal damage.

Acta Neurobiol Exp (Wars) 2017 ;77(4):373-381

Department of Physiology, Faculty of Medicine, Istanbul Yeni Yuzyil University, Istanbul, Turkey.

Prolonged or repeated seizures have been shown to cause spontaneous recurrent seizures, increased anxiety‑related behavior, locomotor hyperactivity, impaired functions of learning and memory, and neuronal damage in the hippocampus and other brain regions in animals. Mice and rats treated with antimuscarinic drugs after fasting for two days or less develop convulsions after being allowed to eat ad libitum. To address whether such behavioral and neuroanatomic changes occur following these convulsions, mice treated i. Read More

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August 2018
4 Reads

Effects of ascorbic acid on anxiety state and affect in a non-clinical sample.

Acta Neurobiol Exp (Wars) 2017 ;77(4):362-372

Department of Internal Medicine, Federal University of Santa Catarina, Florianópolis, Brazil.

Objective Given that the literature data indicates that ascorbic acid may have an anxiolytic effect, we hypothesized that a single oral administration of ascorbic acid could acutely affect emotional states. Methods The effects of acid ascorbic supplementation on anxiety and other emotional states were evaluated by the State‑Trait Anxiety Inventory (STAI), and Visual Analogue Mood Scale (VAMS). Immediately before, and 2 hours after receiving a single ascorbic acid dose (1000 mg) or placebo, 142 graduate students were evaluated by the STAI and VAMS in a randomized, double‑blind, placebo‑controlled trial. Read More

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August 2018
4 Reads

Interaction between the serotoninergic and GABAergic systems in frog retina as revealed by electroretinogram.

Acta Neurobiol Exp (Wars) 2017 ;77(4):351-361

Department of Physiology, Medical University of Sofia, Department of Physiology, Medical University of Sofia.

Functional interactions between serotoninergic and GABAergic systems in the vertebrate retina are largely unknown. In this study, the effects of isolated or combined stimulation of the serotonin receptors (with 100 μM serotonin) and ionotropic GABAA and GABAC receptors (with 5 mM TACA) on the electroretinographic (ERG) ON (b‑wave) and OFF (d‑wave) responses were investigated in frog eyecup preparations. It was found that serotonin alone produced a significant enhancement of the b‑ and d‑wave amplitude, while TACA alone caused its marked diminution. Read More

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August 2018
1 Read

Axonal outgrowth stimulation after alginate/mesenchymal stem cell therapy in injured rat spinal cord.

Acta Neurobiol Exp (Wars) 2017 ;77(4):337-350

Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.

Despite strong efforts in the field, spinal cord trauma still belongs among the untreatable neurological conditions at present. Given the complexity of the nervous system, an effective therapy leading to complete recovery has still not been found. One of the potential tools for supporting tissue regeneration may be found in mesenchymal stem cells, which possess anti‑inflammatory and trophic factor‑producing properties. Read More

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August 2018
3 Reads

Effects of different delayed exercise regimens on cognitive performance in fimbria‑fornix transected rats.

Acta Neurobiol Exp (Wars) 2017 ;77(4):323-336

The Unit for Cognitive Neuroscience, Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Studies have shown that exercise can positively influence cognitive performance after brain injury. This study investigated the effects of different exercise regimens on allocentric place learning after fimbria‑fornix (FF) transection. One hundred and sixteen pre‑shaped rats were subjected either to a mechanical transection of the FF or control sham surgery and divided into following groups: i) no exercise (NE), ii) voluntary exercise in a running wheel (RW), iii) forced swimming exercise administered as interval training of short (3x5 min) duration (FS‑SI), iv) forced swimming exercise administered as interval training of long (3x15 min) duration (FS‑LI), v) forced swimming exercise administered as one session of short (5 min) duration (FS‑SS), and vi) forced swimming exercise administered as one session of long (15 min) duration (FS‑LS). Read More

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August 2018
1 Read

Antiallodynic effect of intrathecal resiniferatoxin on neuropathic pain model of chronic constriction injury.

Acta Neurobiol Exp (Wars) 2017 ;77(4):317-322

Department of Physiotherapy, College of Nursing of the Federal University of Alfenas - UNIFAL, Alfenas, Brazil.

Introduction: Injuries and/or dysfunctions in the somatosensory system can lead to neuropathic pain. Transient receptor potential vanilloid sub‑type 1 (TRPV1) play an important role in the development of allodynia and hyperalgesia following injury and the ensuing inflammatory conditions. Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 agonist and many different administration routes are available for different mechanisms and different effects. Read More

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August 2018
2 Reads

Top-down and bottom-up competition in visual stimuli processing.

Acta Neurobiol Exp (Wars) 2017 ;77(4):305-316

Psychophysiology Laboratory, Institute of Psychology Jagiellonian University, Kraków, Poland.

Limited attention capacity results that not all the stimuli present in the visual field are equally processed. While processing of salient stimuli is automatically boosted by bottom‑up attention, processing of task‑relevant stimuli can be boosted volitionally by top‑down attention. Usually, both top‑down and bottom‑up influences are present simultaneously, which creates a competition between these two types of attention. Read More

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Omitted Stimulus Potential Depends on the Sensory Modality.

Acta Neurobiol Exp (Wars) 2017 ;77(4):297-304

Facultad de Medicina, Universidad Autónoma de Campeche, Colonia Buenavista, San Francisco de Campeche, Campeche, México.

Determining the characteristics of Omitted Stimulus Potential (OSP) parameters using different sensory modalities is important because they reflect timing processes and have a substantial influence on time perception. At the same time, the central mechanisms of time perception associated with sensory processing can modulate cortical brain waves related to cognition. This experiment tested the relationship between parameters of the whole OSP brain wave when trains of auditory, visual or somatosensory stimuli were applied. Read More

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Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males.

Acta Neurobiol Exp (Wars) 2017 ;77(4):269-296

Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA; CoMeD, Inc., Silver Spring, MD, USA; CoMeD, Inc., Silver Spring, MD, USA.

The prevalence of neurodevelopmental disorders (NDs), including autism spectrum disorder, attention‑deficit/hyperactivity disorder, tic disorder, obsessive‑compulsive disorder, and emotional disturbances, has increased notably in the past few decades. To date, debate continues as to the origins of NDs. Increases in widespread exposure to and bioaccumulation of chemical neurotoxicants have paralleled the upsurge in NDs, and are suggested to be causal agents for NDs. Read More

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August 2018
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In vivo stimulation of locus coeruleus: effects on amygdala subnuclei.

Acta Neurobiol Exp (Wars) 2017 ;77(3):261-268

Departamento de Enfermería, Fisioterapia y Medicina, Universidad de Almería, Spain. Ctra. Sacramento s/n, Almeria, Spain.

The locus coeruleus (LC) is the major noradrenergic nucleus and sends projections to almost all brain areas. A marked increase in norepinephrine release has been demonstrated in several brain areas in response to exposure to acute stressful stimuli, especially those innervated by LC projections. One of the brain areas innervated by LC neurons is the amygdala, a structure highly involved in emotional processes and memory formation. Read More

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July 2018
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Marble burying as compulsive behaviors in male and female mice.

Acta Neurobiol Exp (Wars) 2017 ;77(3):254-260

UInterfaculty Biomedical Research Facility (IBF), Heidelberg Universität, Heidelberg, Germany.

Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g. Read More

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July 2018
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Effects of individual stressors used in a battery of "chronic unpredictable stress" on long-term plasticity in the hippocampus of juvenile rats.

Acta Neurobiol Exp (Wars) 2017 ;77(3):244-253

Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia;

We have studied alterations in the properties of long-term potentiation (LTP) in hippocampal slices of juvenile rats induced by the exposure of animals to different individual stressors usually used in batteries of chronic unpredictable stress (CUS), a widely used model of depression. Social isolation for 16 h did substantially affect neither the magnitude and nor the development of LTP. The effects of stroboscopic illumination and water deprivation appeared most severe, though opposite: the first stressor had activating effect, whereas the second one inhibited the development of LTP. Read More

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July 2018
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Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task.

Acta Neurobiol Exp (Wars) 2017 ;77(3):236-243

Department of Psychobiology & Mind, Brain and Behavior Research Center (CIMCYC). University of Granada, Spain;

The parabrachial complex has been related to the processing of both rewarding and aversive signals. This pontine area is activated after the gastrointestinal administration of rewarding nutrients, in taste aversion learning, and in response to the reinforcing and aversive effects of some drugs of abuse. Electrical stimulation of this region can induce, in different animals, preference or aversion behaviors towards a place in a rectangular three-chamber maze task. Read More

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July 2018
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Assessment of type 1 and type 3 deiodinase expression levels in depressive disorders.

Acta Neurobiol Exp (Wars) 2017 ;77(3):225-235

Department of Medical Biochemistry, Medical University of Lodz, Poland.

A depressive disorder is a disease characterized by a heterogenous background. The important processes observed and diagnosed in depressed patients indicate that the etiology of depression may include disturbances in thyroid hormone (TH) levels and the occurrence of immune-inflammatory activation. Type 1 (DIO1) and type 3 (DIO3) iodothyronine deiodinases are the enzymes which determine the peripheral and tissue levels of TH, but also interfere with immunological cells and inflammatory processes. Read More

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July 2018
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Nucleus accumbens local field potential power spectrums, phase-amplitude couplings and coherences following morphine treatment.

Acta Neurobiol Exp (Wars) 2017 ;77(3):214-224

Department of Physiology, Faculty of Science, Prince of Songkla University (PSU), Hat Yai, Songkhla, Thailand; Research Unit for EEG Biomarkers of Neuronal diseases, Faculty of Science, Prince of Songkla University (PSU), Hat Yai, Songkhla, Thailand.

In the past decade, neural processing has been extensively studied in cognitive neuroscience. However, neural signaling in the nucleus accumbens (NAc) that might clarify reward process remained to be investigated. Male Swiss albino ICR mice implanted with intracranial electrodes into the NAc and the ventral tegmental area (VTA) were used for morphine administration and local field potential (LFP) recording. Read More

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July 2018
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