2,039 results match your criteria Acta neurobiologiae experimentalis[Journal]


Association between scripture memorization and brain atrophy using magnetic resonance imaging.

Acta Neurobiol Exp (Wars) 2020 ;80(1):90-97

Department of Electrical and Computer Engineering, COMSATS University Islamabad (CUI), Pakistan.

We investigated the association between scripture memorization and brain tissue using magnetic resonance imaging techniques. Participants comprised 63 healthy adults between the ages of 35 and 80 years old with no neurological or psychological disorders. Of these, 19 had completely memorized the Quran, 28 had partially memorized parts of Quran while 16, the control group, had not committed the Quran into their memory. Read More

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January 2020
2.244 Impact Factor

EEG correlates of cognitive load in a multiple choice reaction task.

Acta Neurobiol Exp (Wars) 2020 ;80(1):76-89

Otto von Guericke University of Magdeburg, Germany.

The present study aimed to examine EEG correlates of cognitive load in a task, in which multiple stimulus‑response mappings have to be maintained in working memory (WM) combined with selective inhibition of irrelevant stimulus‑response mappings on every trial. Twenty‑four healthy younger adults had to perform choice reaction tasks differed in the number of S‑R mappings and motor response requirements. Performance was lower in the high load than in the low load condition. Read More

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January 2020

A ten year longitudinal examination of the incidence rate and age of childhood encephalopathy diagnoses in an autism spectrum disorder diagnosed cohort.

Acta Neurobiol Exp (Wars) 2020 ;80(1):66-75

Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA.

Autism spectrum disorder (ASD) is defined by persistent deficits in social communication/interaction and stereotypic behaviors with many diagnosed persons experiencing a developmental regression at >1 year‑old. It was hypothesized that progressive childhood encephalopathy is an important etiological factor in ASD pathogenesis. This hypothesis‑testing study examined the relationship between diagnosed childhood encephalopathy and ASD. Read More

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January 2020

Hindbrain metabolic deficiency regulates ventromedial hypothalamic nucleus glycogen metabolism and glucose‑regulatory signaling.

Acta Neurobiol Exp (Wars) 2020 ;80(1):57-65

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, United States.

The catecholamine norepinephrine (NE) links hindbrain metabolic‑sensory neurons with downstream gluco‑regulatory loci, including the ventromedial hypothalamic nucleus (VMN). Exogenous NE up‑regulates VMN expression of glutamate decarboxylase (GAD), biomarker for the gluco‑inhibitory transmitter γ‑aminobutryic acid (GABA). Brain glycogen phosphorylase (GP)‑muscle (GPmm) and ‑brain (GPbb) variants are stimulated in vitro by NE or energy deficiency, respectively. Read More

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January 2020

Moderate exercise prevents the cell atrophy caused by hypothyroidism in rats.

Acta Neurobiol Exp (Wars) 2020 ;80(1):47-56

Department of Physiology, ENCB, Instituto Politécnico Nacional, Mexico City, Mexico,

Adult‑onset hypothyroidism is associated with an increase in cell atrophy of the hippocampal pyramidal neurons. Physical exercise implies diverse actions on the neural tissue that promote neuron proliferation and survival. The beneficial effects of exercise seem to be inversely linked to its intensity, so that strenuous exercise has reduced protective effects. Read More

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January 2020

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells.

Acta Neurobiol Exp (Wars) 2020 ;80(1):38-46

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Following nerve tissue damage, various events, such as inflammatory responses, microglial activation, endoplasmic reticulum stress, and apoptosis, can occur, which all lead to cell death, prevent axonal growth, and cause axonal circumvolution. So far, several researchers have tended to adopt strategies to reduce the harmful conditions associated with neurological disorders, and stem‑cell‑based therapy is one of those promising strategies. Epidermal neural crest stem cells (EPI‑NCSCs) are a type of stem cell that has widely been employed for the treatment of various neurological disorders. Read More

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January 2020

C60 fullerenes increase the intensity of rotational movements in non‑anesthetized hemiparkinsonic rats.

Acta Neurobiol Exp (Wars) 2020 ;80(1):32-37

Department of Movement Physiology, Bogomoletz Institute of Physiology, Kyiv, Ukraine.

The effect of C60 fullerene aqueous colloid solution (C60FAS) on the intensity of long‑lasting (persisting for one hour) rotational movements in non‑anesthetized rats was investigated. For this purpose, an experimental hemiparkinsonic animal model was used in the study. Rotational movements in hemiparkinsonic animals were initiated by the intraperitoneal administration of the dopamine receptor agonist apomorphine. Read More

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January 2020
2.244 Impact Factor

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice.

Acta Neurobiol Exp (Wars) 2020 ;80(1):19-31

Department of Physiology, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla, Thailand;

The efficacy of pseudoephedrine (PSE) as a nasal decongestant has been well‑demonstrated; however, PSE is strictly prescribed as a control substance due to its controversial psychostimulant effects. Although standard stimulatory drugs increase exploratory behavior and stimulate the dopamine system, the exact effects of PSE on locomotion and electrical activity in the striatum have not been determined. This study aimed to examine and compare the locomotor activities, local field potential (LFP) and sleep‑wake patterns produced by PSE and morphine, which is a standard drug used to promote psychomotor activity. Read More

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January 2020

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats.

Acta Neurobiol Exp (Wars) 2020 ;80(1):1-18

Faculty of Medicine, International Medical University, IMU Clinical School, Seremban, Malaysia.

Poly (lactide‑co‑glycolide) (PLGA) nanoparticles (NPs) are biodegradable carriers that participate in the transport of neuroprotective drugs across the blood brain barrier (BBB). Targeted brain‑derived neurotrophic factor (BDNF) delivery across the BBB could provide neuroprotection in brain injury. We tested the neuroprotective effect of PLGA nanoparticle‑bound BDNF in a permanent middle cerebral artery occlusion (pMCAO) model of ischemia in rats. Read More

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January 2020

Roux‑en‑Y gastric bypass surgery triggers rapid DNA fragmentation in vagal afferent neurons in rats.

Acta Neurobiol Exp (Wars) 2019 ;79(4):432-444

Department of Veterinary Biosciences and Diagnostic Imaging, University of Georgia, Athens, USA;

Previous studies have shown that Roux‑en‑Y gastric bypass (RYGB), one of the most effective weight loss treatments for obesity, results in neurodegenerative responses in vagal afferent gut‑brain connection reflected by microglia activation and reduced sensory input to the nucleus tractus solitarius (NTS). However, it is not known whether RYGB‑induced microglia activation is the cause or an effect of the reported neuronal damage. Therefore, the aim of this study was to establish the order of neurodegenerative responses in vagal afferents after RYGB in the nodose ganglia (NG) and NTS in male and female rats. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033620PMC
January 2019

Successful BCI communication via high‑frequency SSVEP or visual, audio or tactile P300 in 30 tested volunteers.

Acta Neurobiol Exp (Wars) 2019 ;79(4):421-431

BrainTech Ltd., Warsaw, Poland.

In the pursuit to clarify the concept of "BCI illiteracy", we investigated the possibilities of attaining basic binary (yes/no) communication via brain‑computer interface (BCI). We tested four BCI paradigms: steady‑state visual evoked potentials (SSVEP), tactile, visual, and auditory evoked potentials (P300). The proposed criterion for assessing for the possibility of communication are based on the number of correct choices obtained in a given BCI paradigm after a short calibration session, without prior training. Read More

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January 2019

Lovastatin alters neurotrophin expression in rat hippocampus‑derived neural stem cells in vitro.

Acta Neurobiol Exp (Wars) 2019 ;79(4):413-420

Food and Drug Research Institute, Iran Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran.

Neural stem/progenitor cells hold valuable potential for the treatment of neurodegenerative disorders. The modulation of intrinsic growth factor expression, such as neurotrophins and their receptors, is a necessary step in achieving neural stem cells (NSCs) therapy. The statins have recently been reported to provide both anti‑inflammatory and neuroprotective effects. Read More

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January 2019

Oppel-Kundt illusion balance.

Acta Neurobiol Exp (Wars) 2019 ;79(4):399-412

Institute of Research of Biological Systems and Genetics, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Perceptual estimates of spatial dimensions of visual objects depend on their shape and surface attributes. The present psychophysical study emphasizes two main contributors to the Oppel‑Kundt illusion: the outline of the filled space and the mode of filling. In past experiments, both factors have been considered significant. Read More

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January 2019

When is the brain ready for mental actions? Readiness potential for mental calculations.

Acta Neurobiol Exp (Wars) 2019 ;79(4):386-398

Action and Cognition Laboratory, Institute of Psychology, Faculty of Social Sciences, Adam Mickiewicz University in Poznan, Poznan, Poland,

While the preparatory neural mechanisms of real and imagined body movements have been extensively studied, the underpinnings of self‑initiated, voluntary mental acts are largely unknown. Therefore, using electroencephalography (EEG), we studied the time course and patterns of changes in brain activity associated with purely mental processes which start on their own, without an external or interoceptive stimulation. We compared EEG recordings for decisions to perform mental operations on numbers, imagined finger movements, and actual finger movements. Read More

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January 2019

Physical activity and environmental enrichment: Behavioural effects of exposure to different housing conditions in mice.

Acta Neurobiol Exp (Wars) 2019 ;79(4):374-385

Department of Psychobiology, Faculty of Psychology, University of Valencia, Spain;

Enriched environments and exercise provide complex environmental stimulation that can induce emotional and cognitive changes; however, few studies have evaluated the effects of these two components on other behaviours, such as novelty seeking or pain sensitivity. The aim of the present study was to investigate the influence of voluntary physical activity provided through different housing conditions on anxiety, locomotor activity, pain sensitivity, and exploration. Male mice at postnatal day (PND) 21 and were randomly assigned to one of four different conditions on PND 28: Marlau cages (MC), a standardized cage designed to provide a complex environment; physical exercise in large groups (PE‑8); physical exercise in small groups (PE‑4); or a standard environment (SE). Read More

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January 2019

Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure.

Acta Neurobiol Exp (Wars) 2019 ;79(4):367-373

Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, USA;

The national incidence of neonatal abstinence syndrome has dramatically increased over the last decade due to an increase in antenatal opioid exposure. Recent human and animal studies suggest that antenatal opioid exposure impacts the developing brain. The purpose of this study is to evaluate the effects of perinatal methadone exposure on myelination in multiple regions in the developing rat brain. Read More

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January 2019

Crocin acts as a neuroprotective mediator against methylphenidate‑induced neurobehavioral and neurochemical sequelae: Possible role of the CREB-BDNF signaling pathway.

Acta Neurobiol Exp (Wars) 2019 ;79(4):352-366

Department of Cellular and Molecular biology, Faculity of Science, Isalamic Azad University of Karaj, Karaj, Iran.

Methylphenidate (MPH) abuse causes adverse neurobehavioral and neurochemical effects. Some herbal components such as crocin have shown neuroprotective properties. The current study evaluates the potential role of the cyclic AMP response element binding protein (CREB)‑brain‑derived neurotrophic factor (BDNF) signaling pathway in mediating the neuroprotective effects of crocin against MPH‑induced neurotoxicity in rats. Read More

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January 2019

Chondroitin sulfate metabolism in the brain.

Acta Neurobiol Exp (Wars) 2019 ;79(4):338-351

Laboratory of Epileptogenesis, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.

Over the last twenty years chondroitin sulfate (CS) has become a focus of interest of neuroscience due to its indubitable role in shaping axonal growth, synaptic plasticity and glial scar forming. Various patterns of sulfation give rise to various CS molecules with different properties that are capable of interactions with a plethora of molecules, including growth factors, receptors and guidance molecules. The involvement of CS chains has been implicated in visual critical period regulation, memory formation, spinal cord regeneration. Read More

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January 2019

Updating the picture of layer 2/3 VIP-expressing interneuron function in the mouse cerebral cortex.

Authors:
Anna Posłuszny

Acta Neurobiol Exp (Wars) 2019 ;79(4):328-337

Laboratory of Visual Neurobiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland;

For years, interneurons expressing vasoactive intestinal peptide (VIP) interneurons and their function within the neocortex have been shrouded in mystery. Their relatively small size and minimal representation in the cortex have made investigation difficult. Due to their service role performed in co‑operation with glia and blood vessels to supply energy during neuronal activation in the brain, the contribution of VIP interneurons to local neuronal circuit function was not appreciated. Read More

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January 2019

Spinal cord regeneration using dental stem cell-based therapies.

Acta Neurobiol Exp (Wars) 2019 ;79(4):319-327

Department of Orthopaedics, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, P.R. China;

Spinal cord injury (SCI) is traumatic central nervous system damage resulting in a motor and sensory dysfunction that usually causes a severe and permanent paralysis. Today, the treatment of SCI principally includes surgical treatment, pharmacological treatments and rehabilitation therapies, which target secondary events determining only some clinical improvements in patients. SCI is still a worldwide problem in the clinic and remains a big challenge for neuroscientists and neurologists throughout the world. Read More

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January 2019

Stimulus-seeking in rats is accompanied by increased c‑Fos expression in hippocampal CA1 as well as short 22 kHz and flat 50 kHz calls.

Acta Neurobiol Exp (Wars) 2019 ;79(3):309-317

Behavior and Metabolism Research Laboratory, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland;

We determined CA1 hippocampal field to be involved in self-exposure, a type of novelty‑seeking behaviour that has also been associated with short 22 kHz and flat 50 kHz ultrasonic vocalizations (USV) in adult male Long-Evans rats. Rats were habituated for three days to a self-exposure cage with two nose-poke holes. On day four, the animals from the experimental group were allowed to turn the cage light off for 5 s with a nose‑poke (test/self‑exposure session), while rats from control-yoked group had changing light conditions coupled and identical to the experimental animals. Read More

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February 2020
2 Reads

Cell-based immunofluorescence assay for screening the neurogenesis potential of new drugs in adult hippocampal neural progenitor cells.

Acta Neurobiol Exp (Wars) 2019 ;79(3):302-308

Department of Neurology, The Second Hospital of Hebei Medical University, Hebei, China,

Preclinical studies have suggested that increased adult neurogenesis in the hippocampus might have potential therapeutic effects for Alzheimer's disease and depression; therefore, it is a target for the treatment of some brain diseases. In this technical communication, we propose a cell-based fluorescence assay to study the neurogenesis of adult hippocampal progenitor cells that can be used for high-throughput screening of drugs promoting neurogenesis. Three fluorescent dyes (DAPI, Alexa Fluor 488, and Alexa Fluor 594) and a fluorescence spectrophotometry reader were used, which confirmed that the mutual interference of the three fluorescent dyes is very low. Read More

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February 2020
1 Read

Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter-hemispheric coherence.

Acta Neurobiol Exp (Wars) 2019 ;79(3):290-301

Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Canada,

Post-stroke neurological deficits, such as sensorimotor impairments, are often permanent and a leading cause of disability. Stroke is also associated with changes in neuronal synchrony among different brain areas. Multiple studies demonstrated that non-invasive brain stimulation, such as transcranial direct current stimulation (tDCS), enhances the efficacy of existing rehabilitative therapies. Read More

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February 2020
1 Read

The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.

Acta Neurobiol Exp (Wars) 2019 ;79(3):276-289

Department of Cellular Signaling, M. Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

Parkin and alpha-synuclein (α-syn) are two key proteins involved in the pathophysiology of Parkinson's disease (PD). Oligomerization/aggregation and excessive secretion of α-syn contributes to PD through free radical stress, mitochondrial impairment, and synaptic dysfunction. Parkin, an E3 ubiquitin ligase, is considered to be a pleiotropic, neuroprotective protein that modulates metabolic turnover and the accumulation of α-syn. Read More

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February 2020
3 Reads

Effects of maternal thyroid hormone deficiency on differentiation of mesenchymal stem cells in CSF-exposed neonatal Wistar rats.

Acta Neurobiol Exp (Wars) 2019 ;79(3):270-275

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Cerebrospinal fluid (CSF) contains growth and neurotrophic factors which regulate proliferation, differentiation, and neurogenesis. Thyroid hormones play a crucial role in the development of the nervous system and hypothyroidism during development of embryos leads to defects in the nervous system. This study aimed to survey the effects of rat neonatal CSF collected from induced hypothyroid mothers on differentiation of bone marrow mesenchymal stem cells (BM-MSCs). Read More

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February 2020
2 Reads

Isolation and characterization of human amniotic fluid and SH-SY5Y/ BE(2)-M17 cell derived exosomes.

Acta Neurobiol Exp (Wars) 2019 ;79(3):261-269

Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

The application of stem cells as a therapy for degenerative disease holds great promise. Substantial evidence suggests that stem cell derived exosomes are a novel cell-free therapy for the corresponding cells. Exosomes are less complex as compared to their parental cells, due to the fewer number of membrane proteins. Read More

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February 2020
1 Read

Dexamethasone induces alterations of slow wave oscillation, rapid eye movement sleep and high-voltage spindle in rats.

Acta Neurobiol Exp (Wars) 2019 ;79(3):251-260

Department of Biology, Faculty of Science, Prince of Songkla University, Songkhla, Thailand.

Glucocorticoids arising from chronic stress and long-term inflammatory treatment with corticosteroids are both associated with neuropathology and cognitive impairments. Many previous studies have focused on changes in brain morphology and deficits in learning behavior. However, effects of long-term exposure to stress hormones on electrical brain signaling and sleep-wake patterns have remained largely unexplored. Read More

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February 2020
6 Reads

Differential expression of the c-fos protein and synaptophysin in zebrin II positive and zebrin II negative cerebellar cortical areas in 4-aminopyridine seizures.

Acta Neurobiol Exp (Wars) 2019 ;79(3):238-250

Department of Anatomy, Faculty of Medicine, University of Szeged, Szeged, Hungary.

The present study examined temporal activation patterns of rat cerebellar cortical neurons in 4-aminopyridine induced seizures, using c-fos protein as a marker of neuronal activity. C-fos-containing cells were counted in each cerebellar cortical layer, and cell count was compared between zebrin II positive and zebrin II negative bands of the lobules of the vermis and cerebellar hemispheres. We found significant activation of granule cells and interneurons of the molecular layer in zebrin II positive bands. Read More

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February 2020
1 Read

Alteration of oxidative stress markers and behavior of rats in a novel model of depression.

Acta Neurobiol Exp (Wars) 2019 ;79(3):232-237

Serbsky National Medical Research Center of Psychiatry and Narcology, Department of Fundamental and Applied Neurobiology, Moscow, Russia.

Emotional stress is considered a serious pathogenetic factor of depression. In this study an ultrasound model of emotional stress developed in our laboratory was applied. It is characterized by the use of ultrasound as the stressor agent. Read More

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February 2020
1 Read

Influence of rhythmic light stimulation on orientation signal within visual cortex columns in the cat.

Acta Neurobiol Exp (Wars) 2019 ;79(3):225-231

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia.

The present study used optical imaging to investigate the development of the optical signal within orientational columns in primary visual cortex of cats reared under conditions of rhythmic light stimulation. Results showed that, although inter-columnar spacing was unchanged, a 3-5-fold decrement in optical signal from orientation columns and a drastic decline in contrast sensitivity was observed in both areas 18 and 17. These data suggest the modification of cortical columnar functioning under artificially correlated synchronization of retinal input. Read More

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February 2020

The effect of bupropion augmentation of minocycline in the treatment of depression.

Acta Neurobiol Exp (Wars) 2019 ;79(2):217-224

Department of Pharmacology, SVKM'S Dr. Bhanuben Nanavati College of Pharmacy, Mithibai Campus, Mumbai, India.

The aim of the current study was to analyse the augmentation of minocycline with bupropion in treating depression. 'Saline' (10 ml/kg), 'minocycline per se' (25 mg/kg), 'minocycline per se' (50 mg/kg), 'bupropion per se' (5 mg/kg), 'bupropion per se' (10 mg/kg) and 'bupropion + minocycline' (5 mg/kg + 25 mg/kg each) were administered to mice via the intraperitoneal route. In the forced swim and tail suspension test, the immobility period was analysed after 30 min of the treatment. Read More

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January 2020
1 Read

miRNA-223-3p and let-7b-3p as potential blood biomarkers associated with the ischemic penumbra in rats.

Acta Neurobiol Exp (Wars) 2019 ;79(2):205-216

Department of Neurology, The First Affiliated Hospital of Guangxi Medical University in Nanning, China,

The present study aimed to identify commonalities in the microRNA (miRNA) expression profiles of the brain ischemic penumbra and the blood after hyperacute ischemic stroke and then to address whether the miRNA profile of blood has potential usefulness as a diagnostic biomarker of hyperacute ischemic stroke. Blood was collected from the jugular vein 4 h after permanent middle cerebral artery occlusion (pMCAO). After venous blood was collected, the rats were decapitated immediately, and brain ischemic penumbra samples were collected. Read More

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January 2020
3 Reads

N1-P2: Neural markers of temporal expectation and response discrimination in interval timing.

Acta Neurobiol Exp (Wars) 2019 ;79(2):193-204

Department of Cognitive Science, Graduate School of Informatics, METU, Ankara, Turkey.

Humans use temporal regularities in their daily life to act in accordance with future events in the most efficient way. To achieve this, humans build temporal expectations and determine a template action that is in line with those expectations. In this temporal trisection study, we aimed to study the neurophysiological counterparts of temporal expectation and response discrimination. Read More

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January 2020
2 Reads

Modulation of catalase, copper and zinc in the hippocampus and the prefrontal cortex in social isolation-induced depression in male rats.

Acta Neurobiol Exp (Wars) 2019 ;79(2):184-192

Physiology Department, Tehran University of Medical Science, Tehran, Iran,

Depression is a chronic illness of unknown etiology. Trace elements, such as copper and zinc, and defense antioxidants, such as catalase, are important factors that determine the clinical course of brain diseases. Furthermore, altered glucose metabolism in hippocampus and prefrontal cortex has been associated with depression. Read More

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January 2020
1 Read

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts.

Acta Neurobiol Exp (Wars) 2019 ;79(2):169-183

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan.

Cadmium, a heavy metal with no physiological function in the human body, is considered a bio-hazard. It is also considered to be a potent neurotoxin. The primary sources of cadmium exposure are diet and cigarette smoke. Read More

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January 2020
2 Reads

Short-term exposure to high‑intensity sound induces hearing loss and apoptosis in guinea pigs.

Acta Neurobiol Exp (Wars) 2019 ;79(2):155-168

Institute of Disaster Medicine, Tianjin University, Tianjin, China,

The aim of this study was to investigate the effect and underlying mechanisms of short-term high-intensity sound exposure on guinea pigs to mimic the effects of non-lethal anti-riot weapons. A total of 92 male adult guinea pigs were exposed to high-intensity sound at 0 dB, 110 dB and 130 dB for 5 min. Basic clinical observation, repellent behaviour detection, peripheral blood routine examination, serum cortisol detection and hearing ability assessment were performed to analyse the functional changes after high intensity sound exposure. Read More

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January 2020
2 Reads

The effects of moderate running exercise and L-tyrosine on penicillin-induced epileptiform activity in rats.

Acta Neurobiol Exp (Wars) 2019 ;79(2):148-154

Department of Physiology of Medicine, Ondokuz Mayıs University, Samsun, Turkey.

Regular exercise and amino acid supplementation, popular approaches toward the reduction of epileptic seizures, have been extensively researched. This study was conducted to evaluate the effects of treadmill exercise and L-tyrosine treatment on the frequency and amplitude of epileptiform activity in rats. A total of 32 male albino Wistar rats were randomly divided into four groups: control, exercise, L-tyrosine, and exercise + L-tyrosine. Read More

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January 2020
3 Reads

Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus.

Acta Neurobiol Exp (Wars) 2019 ;79(2):133-147

Department of Biological Sciences, Faculty of Science and Arts, Middle East Technical University, Ankara, Turkey.

It is well known that the fetal ethanol exposure and prenatal stress may have adverse effects on brain development. Interestingly, some morphological and functional recovery from their teratogenic effects that take place during brain maturation. However, mechanisms that underlie this recovery are not fully elucidated. Read More

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January 2020

Coumarins as potential supportive medication for the treatment of epilepsy.

Acta Neurobiol Exp (Wars) 2019 ;79(2):126-132

Isobolographic Analysis Laboratory, Institute of Rural Health, Lublin, Poland;

Epilepsy, one of the most common neurological disorders, is a chronic disease of the brain manifested by seizures due to sudden, spontaneous bioelectrical discharges in nerve cells. An estimated 50 million people worldwide suffer from epilepsy. Antiepileptic drugs are the mainstream treatment for epilepsy; however, the drug resistance occurring in 20-30% of patients and side effects of available medications have resulted in a search for natural remedies that can support disease therapy. Read More

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January 2020
1 Read

Autism spectrum disorder and mercury toxicity: use of genomic and epigenetic methods to solve the etiologic puzzle.

Authors:
Mark E McCaulley

Acta Neurobiol Exp (Wars) 2019 ;79(2):113-125

Yampa Valley Medical Associates, Steamboat Springs, USA;

Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental condition of unknown etiology. Mercury is a common, highly neurotoxic heavy metal. The similarities of neurologic manifestations of mercury exposure and ASD raise an intriguing hypothetical question: Is ASD, at least partially, a manifestation of mercury toxicity? The fetus is particularly vulnerable to mercury exposure from the "double jeopardy" combination of the genetics of his mother and his own genetics, as relates to mercury toxicity. Read More

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January 2020
4 Reads

Increased short‑term food intake after external lateral parabrachial subnucleus lesions in rats.

Acta Neurobiol Exp (Wars) 2019 ;79(1):101-111

Department of Psychobiology and Mind, Brain and Behaviour Research Center (CIMCYC), Campus of Cartuja, University of Granada, Spain.

The vagus nerve and several brainstem nuclei to which it projects have been closely associated with food intake. The aim of this study was to determine the degree to which the same or different information on food intake is processed by this nerve and by one of these nuclei, the external lateral parabrachial subnucleus (LPbNe). For this purpose, we analyzed the solid and liquid food intake of Wistar rats subjected to vagal deafferentation with capsaicin or lesions of the LPbNe. Read More

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September 2019
1 Read

Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression.

Acta Neurobiol Exp (Wars) 2019 ;79(1):92-100

Department of Anatomy, Histology and Embryology, Semmelweis University, Faculty of Medicine, Budapest, Hungary;

In a previous study, methylenedioxypyrovalerone (MDPV), a designer drug of the cathinone family, caused selective enhancement of Caspase3 immunoreactive (Casp3+) apoptotic cells in the nucleus accumbens (NAc) of 7‑day‑old mice. To further elaborate on the mechanism underlying MDPV‑elicited apoptosis, here, we investigated the appearance of Casp3+ cells in developing neural tube explants of E12.5 mice, following MDPV treatment in vitro. Read More

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September 2019
2 Reads

Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures.

Acta Neurobiol Exp (Wars) 2019 ;79(1):86-91

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;

Epilepsy is a life‑threatening disorder that is marked by recurrent seizures. Febrile seizure is a common neurological disorder observed in neonates. In many cases, reducing body temperature can prevent febrile seizure. Read More

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September 2019
6 Reads

Neuroprotective effects of lipopolysaccharide and naltrexone co‑preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat.

Acta Neurobiol Exp (Wars) 2019 ;79(1):73-85

Department of Pharmacology and Toxicology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Preconditioning with lipopolysaccharide (LPS) or opioid antagonists has a neuroprotective effect in ischemic insults. However, the co‑preconditioning effect of toll‑like receptor ligands and opioid antagonists has not been investigated. In this study we examined the neuroprotective effect of LPS and naltrexone (NTX) preconditioning and co‑preconditioning in unilateral selective hippocampal ischemia in rats to assess for possible synergistic protective effects. Read More

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September 2019
1 Read

Pain catastrophizing is associated with altered EEG effective connectivity during pain‑related mental imagery.

Acta Neurobiol Exp (Wars) 2019 ;79(1):53-72

Institute of Psychology, Jagiellonian University, Krakow, Poland.

Pain catastrophizing - defined as a tendency to exaggerate the threat value or seriousness of experienced pain ‑ has been shown to be a risk factor for pain chronification. However, the neural basis of pain catastrophizing remains unclear and requires thorough investigation. This study aimed to explore the relationship between pain catastrophizing and effective connectivity of the pain systems in healthy participants. Read More

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September 2019
3 Reads

The filled-space illusion induced by a single-dot distractor.

Acta Neurobiol Exp (Wars) 2019 ;79(1):39-52

Institute of Biological Systems and Genetics Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.

In the present study, we tested the ability of our computational model of the filled‑space illusion to account for data collected in experiments with stimuli comprising single‑dot distractors. In three sets of experiments, we investigated this illusory effect as a function of distance between the distractor and lateral terminator of the reference spatial interval of the three‑dot stimulus. We found that the model calculations properly predicted all of the observed changes in magnitude of the illusion for stimuli with a single distracting dot placed both within and outside the interval, as well as, for stimuli with two distractors arranged symmetrically relative to the lateral terminator. Read More

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September 2019
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Differences in spatio‑temporal distribution of the visual P3b event-related potential between young men and women.

Acta Neurobiol Exp (Wars) 2019 ;79(1):25-38

Department of Medical Physics, Institute of Physics, University of Silesia, Silesian Center for Education and Interdisciplinary Research, Chorzow, Poland.

Here, we evaluated the P3b potential evoked in a visual two-stimulus oddball paradigm. The experiment was conducted in 20 healthy students (23.1±1. Read More

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September 2019
3 Reads

Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats.

Acta Neurobiol Exp (Wars) 2019 ;79(1):13-24

Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.

Depression is a highly prevalent social disease. Despite significant medical progress, therapeutic solutions for optimising treatment of this disease are still being sought. The aim of this study was to assess, using the forced swimming test, locomotor activity test and two compartment exploratory test, for a reduction in immobility time (a measure of anti-depressant efficacy), locomotor activity and anxiolytic effectiveness after single, repeated, and combined administration of vortioxetine (2. Read More

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September 2019
9 Reads

Distinct classes of low frequency ultrasonic vocalizations in rats during sexual interactions relate to different emotional states.

Acta Neurobiol Exp (Wars) 2019 ;79(1):1-12

Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Poland; Department of Psychiatry, Harvard Medical School, Boston MA, USA.

This study examined low-frequency ultrasonic vocalizations (lUSVs) in rats during two types of sexual interactions; postejaculatory interval (PEI) and barrier - noncontact (NC) test. We report distinct classes of lUSVs that can be assigned to different emotional states; relaxation vs. frustration. Read More

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September 2019
2 Reads

Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats.

Acta Neurobiol Exp (Wars) 2018 ;78(4):358-374

Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Department of Neuroscience, Charles University, Second Faculty of Medicine, Prague, Czech Republic;

Spinal cord injury leads to a robust inflammatory response that is an unfavorable environment for stem cell implantation. In this study, we evaluated the effect of combined therapy of curcumin and mesenchymal stem cells (MSC) on behavioral recovery and tissue sparing, glial scar formation, axonal sprouting and inflammatory responses in a rat experimental model of spinal cord injury (SCI). Balloon-induced compression lesion was performed at thoracic (Th8-9) spinal level. Read More

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May 2019
60 Reads