228 results match your criteria Acta medica academica[Journal]


Dr. Anna Bayerova: Female Pioneer of Medicine in Bosnia and Herzegovina.

Acta Med Acad 2019 12;48(3):337-338

Department of Neurology, University Clinical Center Tuzla and School of Medicine, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina.

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http://dx.doi.org/10.5644/ama2006-124.277DOI Listing
December 2019

Carl Ferdinand von Arlt, Ritter von Bergschmidt (1812-1887): A Pioneer in Ophthalmology.

Acta Med Acad 2019 Dec;48(3):332-336

First Ophthalmological Department, Medical School, National and Kapodistrian University of Athens, Greece.

Carl Ferdinand von Arlt, Ritter von Bergschmidt (1812-1887) was a pioneer in ophthalmology. The purpose of our paper is to highlight his scientific work. He did not only introduce new surgical techniques and invent new instruments in ocular surgery, but also influenced the development of ophthalmology in the 19th century. Read More

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http://dx.doi.org/10.5644/ama2006-124.276DOI Listing
December 2019

To Save a Corpse from Decomposition - the Purpose of Petrification in the Second Half of the 19th Century.

Acta Med Acad 2019 Dec;48(3):328-331

Section of Forensic Medicine and Bioethics, Department of Health Sciences, University of Genoa, Genoa, Italy.

We present this interesting note on the petrification of corpses, published in 1890 in the Italian Journal of Natural Sciences. After a brief review of the oldest forms of embalming, the author, Michele Martone, presents petrification as the only way to obtain the perfect conservation of the corpse. CONCLUSION: This scientific note presents some considerations regarding the constant search of humanity to arrest, if not the death of a person, the decomposition of their body. Read More

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http://dx.doi.org/10.5644/ama2006-124.275DOI Listing
December 2019

Teodora Krajewska, Official Female Doctor of Tuzla and Sarajevo: Medical Practitioner, Woman of Science, Polish Patriot and Feminist.

Acta Med Acad 2019 Dec;48(3):317-327

Department of Medical Sciences of the Academy of Sciences and Arts of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.

A biographical note on Teodora Krajewska (1854-1935) reveals the details of her life and professional activities as an Austro-Hungarian and Yugoslav health officer (Amtsärztin) in Tuzla (1893-1899) and in Sarajevo (1899-1923). Teodora Krajewska, née Kosmowska was the third of nine official female doctors employed by the Austro-Hungarian administration in occupied Bosnia and Herzegovina (BH: 1878-1918) and charged with the special task of popularising public health and hygiene, particularly among Muslim women. A Polish intellectual and fervent patriot from Warsaw, Krajewska had left Congress Poland as a young widow in 1883 to study medicine in Geneva, Switzerland. Read More

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http://dx.doi.org/10.5644/ama2006-124.274DOI Listing
December 2019

Eccentric Macular Hole Formation Following Successful Macular Hole Surgery.

Acta Med Acad 2019 Dec;48(3):312-316

University Clinical Center Tuzla, Department of Ophthalmology, Tuzla, Bosnia and Herzegovina.

Objective: Postoperative eccentric macular hole formation is a rare complication after vitrectomy with internal limiting membrane peeling for a macular hole. We report a rare case of late eccentric macular hole formation following successful macular hole surgery.

Case Report: A 73-year old woman was referred with a long standing full thickness macular hole in both eyes. Read More

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http://dx.doi.org/10.5644/ama2006-124.273DOI Listing
December 2019

An Unusual Bilateral Duplication of the Suprascapular Vein and Its Relation to the Superior Transverse Scapular Ligament Revealed by Anatomage Table.

Acta Med Acad 2019 Dec;48(3):307-311

Department of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens.

Objective: The aim of our paper is to present a rare variation of the suprascapular vein, its incidence and clinical significance.

Case Report: A rare case of a double suprascapular vein was observed in a digitalized human cadaver on Anatomage Table 5.0. Read More

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http://dx.doi.org/10.5644/ama2006-124.272DOI Listing
December 2019

Degloving Injury of the Lower Extremity: Report of Two Cases.

Acta Med Acad 2019 Dec;48(3):303-306

Department of Orthopedic Surgery, General Hospital of Amfissa, Amfissa, Greece.

Objective: The aim of our article is to highlight the importance of the immediate treatment of lower extremity degloving injuries, in order to prevent complications.

Cases Presentation: Here we present two cases of degloving injury of the lower extremity, both resulting from motorway accidents. The first one concerned a 65-year-old man suffering from multiple limb fractures and a degloving injury of the right thigh, which was immediately treated with extensive debridement and primary full-thickness skin graft re-approximation. Read More

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http://dx.doi.org/10.5644/ama2006-124.271DOI Listing
December 2019

Maternal Dental Health Knowledge and Its Relation to the Dental Caries Experience of Their Children in Mamyzawa Camp of Refugees in Erbil, Iraq.

Acta Med Acad 2019 Dec;48(3):294-302

Tishk International University, Dentistry Faculty, Conservative Department, Erbil, Iraq.

Objectives: This study aimed to evaluate the mothers' dental health knowledge and its relation to their children's oral health behavior and practice in a camp of refugees.

Method: This descriptive cross-sectional observational study was conducted in Mamyzawa refugee camp in Erbil City, Iraq, in November 2017. Seventy-nine preschoolers (43 aged 4 years and 36 aged 5 years) and their mothers (79) were chosen for this study. Read More

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http://dx.doi.org/10.5644/ama2006-124.270DOI Listing
December 2019

Neuroenhancing Substances Use, Exam Anxiety and Academic Performance in Bosnian-Herzegovinian First-Year University Students.

Acta Med Acad 2019 Dec;48(3):286-293

Department of Pharmacology, Clinical pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Objective: The aim of this study was to assess the relationship between the use of neuroenhancing substances, exam anxiety and academic performance among first-year Bosnian-Herzegovinian (BH) university students.

Methods: In a cross-sectional study, an ad hoc questionnaire was delivered to a sample of BH first-year university students. The following data were collected: socio-demographic features, consumption of neuroenchancing substances, the Westside Test Anxiety Scale (WTAS) and academic performance. Read More

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http://dx.doi.org/10.5644/ama2006-124.269DOI Listing
December 2019

The Effects of a Workplace Health Promotion Program to Decrease Cadmium Exposure Levels in Nickel-Cadmium Battery Workers.

Acta Med Acad 2019 Dec;48(3):278-285

Department of Public Health, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovak Republic.

Objective: Cadmium exposure is a common problem in the production of nickel-cadmium batteries. However, keeping the respective legislative occupational and safety policies is essential, but there are problems with compliance. We analysed the effect of strategies to increase compliance with precautions during 20132015 on 59 workers at a nickel-cadmium battery factory. Read More

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http://dx.doi.org/10.5644/ama2006-124.268DOI Listing
December 2019

Effects of Treating an Overactive Urinary Bladder in Patients with Multiple Sclerosis.

Acta Med Acad 2019 Dec;48(3):271-277

Medical Faculty, Univerity of Tuzla, Bosnia and Herzegovina.

Objective: The purpose of this study was to evaluate the efficiency of the anticholinergic therapy with oxybutynin and the effects of daily transcutaneous tibial nerve stimulation (TTNS) on the quality of life of patients with an overactive bladder (OAB) and multiple sclerosis (MS).

Patients And Methods: The study was designed as a randomized controlled trial. The patients who suffer from MS underwent urodynamic tests which showed that they had an OAB. Read More

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http://dx.doi.org/10.5644/ama2006-124.267DOI Listing
December 2019

Qualitative Evaluation of the Bracket-Adhesive-Enamel Junction of Metal Orthodontic Brackets: A Preliminary Report.

Acta Med Acad 2019 Dec;48(3):262-270

Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.

Objectives: The purpose of this in vitro investigation was to evaluate qualitatively the surface topography at the bracket-adhesive-enamel junction, bonded to the buccal and lingual surfaces of premolars with composite resin and resin-modified glass-ionomer orthodontic adhesives, using two methods of adhesive removal: a dental explorer and a micro brush.

Methods: Forty premolar surfaces were allocated to four groups of 10/ each, 20/buccal and 20/lingual surfaces. The brackets were bonded to the surface of the enamel and any extra adhesive was removed with a dental explorer or a micro brush. Read More

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http://dx.doi.org/10.5644/ama2006-124.266DOI Listing
December 2019

Occlusal Stress Distribution on the Mandibular First Premolar - FEM Analysis.

Acta Med Acad 2019 Dec;48(3):255-261

Department of Oral Surgery, Faculty of Dentistry, University of Sarajevo.

Objective: The aim of this paper was to analyze the distribution of stress and deformation on the mandibular first premolar under two types of loading (axial and para-axial load of 200 N) using the FEM computer method.

Materials And Method: For this research a µCT scan of the first mandibular premolar was used, and the method used in this research was FEM analysis under two types of loading.

Results: The values of the von Mises stress measured in the cervical part of an intact tooth under axial load were up to 12 MPa, and under paraaxial load over 50 MPa. Read More

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http://dx.doi.org/10.5644/ama2006-124.265DOI Listing
December 2019

Adrianus Spigelius' (1578 - 1625) Ocular Anatomy.

Acta Med Acad 2019 Aug;48(2):250-254

Department of Anatomy, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

The aim was to study Adriaan van den Spiegel's ideas on ocular anatomy. He is better known by his Latinized name as Adrianus Spigelius (1578 - 1625). He was a Flemish physician and anatomist who lived and worked in Padua, where in 1605 he was elected to be Professor of Anatomy and Surgery. Read More

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http://dx.doi.org/10.5644/ama2006-124.264DOI Listing

Bogusławą Keckova: An Official Female Doctor in Bosnia and Herzegovina, 1893-1911.

Acta Med Acad 2019 Aug;48(2):232-249

Department of Cultural and Social Anthropology at the University of Vienna, Vienna, Austria.

The purpose of this paper is to bring to light the biographical details, the professional work and the publishing activities of Bogusławą Keckovą (Bohuslava Kecková in Czech and Keck in German), who functioned as an Austro-Hungarian health officer in Mostar from 1893 to 1911 during the period of the Austro-Hungarian occupation of Bosnia and Herzegovina (BH). Keckovą, who came from Prague, was the second of nine female physicians to be employed by the Austro-Hungarian authorities between 1892 and 1918. Keckovą contributed significantly to the improvement of public health and hygiene in BH, especially by organising the medical treatment of Muslim women. Read More

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http://dx.doi.org/10.5644/ama2006-124.263DOI Listing

A Case of with an Incidental Penetrating Foreign Body in Lumbar 2 Vertebra.

Acta Med Acad 2019 Aug;48(2):230-231

Department of Neurosurgery, Saglik Bilimleri University, Tepecik Research and Training Hospital, Izmir, Turkey.

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http://dx.doi.org/10.5644/ama2006-124.262DOI Listing

MR Imaging of the Hypermobile Lateral Meniscus of the Knee: A Case Report.

Acta Med Acad 2019 Aug;48(2):225-229

Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore.

Objective: The hypermobile lateral meniscus of the knee is a rarely described entity. In this case report we aim to draw attention to the clinical presentation and MR imaging findings of this pathology.

Case Report: We review the clinical and imaging findings that led to the diagnosis of hypermobile lateral meniscus with transient subluxation causing intermittent locking, and which subsequently led to successful surgical treatment. Read More

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http://dx.doi.org/10.5644/ama2006-124.261DOI Listing

A Case of Early FAP Diagnosis with Extraintestinal Manifestations on the Face.

Acta Med Acad 2019 Aug;48(2):217-224

Anatomy Department, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

Objective: Gardner's syndrome is a variant of familial adenomatous polyposis, characterized by gastrointestinal polyps, multiple osteomas, and skin and soft tissue lesions. Diagnosis by means of an understanding of its various symptoms is of great importance.

Case Reposrt: This report presents the case of a 32-year-old man with obvious asymmetry and disfigurement on his face, due to multiple osteomas and soft tissue lesions. Read More

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http://dx.doi.org/10.5644/ama2006-124.260DOI Listing

Subscapularis Myotendinous Junction Tears Presenting with Posterior Shoulder Pain in Overhead Throwing Athletes.

Acta Med Acad 2019 Aug;48(2):205-216

Northwestern University Feinberg School of Medicine, Department of Orthopaedics, Chicago, Illinois, USA.

Objective: Acute inferior subscapularis myotendinous junction injuries are occasionally seen in overhead throwing athletes, and can present with posterior shoulder pain.

Case Reports: Four professional baseball pitchers presented with acute onset of posterior shoulder pain while pitching. After thorough, routine physical examination of the shoulder by the referring orthopaedic surgeon magnetic resonance imaging (MRI) was performed within 7-10 days of the onset of presenting symptoms and interpreted in consensus by 2 fellowshiptrained musculoskeletal radiologists with 9 and 5 years of experience and a musculoskeletal radiology fellow. Read More

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http://dx.doi.org/10.5644/ama2006-124.259DOI Listing

The Incidence of Smoking Habits and the Degree of Nicotine Dependence in Education Workers.

Acta Med Acad 2019 Aug;48(2):193-204

Institute of Public Health, Central Bosnia Canton, Travnik, Bosnia and Herzegovina.

Objective: The aim of this research was to establish the incidence of smoking habits and the level of nicotine dependence in education workers in the Central Bosnia Canton (CBC).

Materials And Methods: The research was conducted in the 2017/2018 school year. It covered education workers in all elementary (N=53) and high schools (N=23), in the area of the CBC. Read More

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http://dx.doi.org/10.5644/ama2006-124.258DOI Listing
August 2019
4 Reads

Ultrasound Evaluation of Radial Nerve Palsy Associated with Humeral Shaft Fractures to Guide Operative Versus Non-Operative Treatment.

Acta Med Acad 2019 Aug;48(2):183-192

University of Arizona/Banner University Medical Center, Tucson, AZ, USA. Departments of Orthopaedics (ME, LMT, JRW, KMM) and Department of Medical Imaging (MST).

Objective: To determine the effectiveness of diagnostic ultrasound (US) at evaluating the condition of the radial nerve in the setting of humeral shaft fractures.

Materials And Methods: An observational study was performed of 18 patients with radial nerve palsy associated with humeral shaft fractures who underwent US examination to assess the condition of the radial nerve.

Results: Six patients with humeral shaft fractures treated nonoperatively in a functional brace had US findings consistent with contusion or stretch radial nerve injury. Read More

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http://dx.doi.org/10.5644/ama2006-124.257DOI Listing

Retrospective Evaluation of the Diagnostic Accuracy of the Modified Alvarado Scoring System (MASS) in a Croatian Hospital.

Acta Med Acad 2019 Aug;48(2):177-182

Department of Medical Laboratory Diagnostics, University Hospital "Sveti Duh", Zagreb, Croatia.

Objective: Diagnosing acute appendicitis (AA) is challenging and this has stimulated surgeons to develop scoring systems that could potentially decrease the rate of misdiagnosis in patients with suspected appendicitis. One of the most widely used today is the Modified Alvarado scoring system (MASS), however its sensitivity and specificity varies a great deal between studies. As a result, we wanted to assess the diagnostic accuracy of MASS retrospectively at our institution to achieve the highest possible value of sensitivity and decrease the number of false negative patients. Read More

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http://dx.doi.org/10.5644/ama2006-124.256DOI Listing

Screening for Carpal Tunnel Syndrome in Patients on Chronic Hemodialysis.

Acta Med Acad 2019 Aug;48(2):167-176

Department for Nephrology, Internal Clinic, University Hospital Centre Osijek.

Objectives: To determine the prevalence of carpal tunnel syndrome risk in patients on chronic hemodialysis (HD) using Levine questionnaire for assessment of carpal tunnel syndrome - related symptoms severity and patients' functional status and to examine the relation of the determined risk with the participants' demographic, anthropometric and laboratory data.

Participants And Methods: This crosssectional study included 78 chronic HD patients at Department for Nephrology in University Hospital Osijek. All participants filled out the Levine questionnaire to examine the severity of carpal tunnel syndrome - related symptoms and their functional state. Read More

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http://dx.doi.org/10.5644/ama2006-124.255DOI Listing

The Presence of Stress, Burnout Syndrome and the Most Important Causes of Working Stress Among Physicians in Primary Health Care - an Observational Study from Banja Luka, Bosnia and Herzegovina.

Acta Med Acad 2019 Aug;48(2):159-166

Department of Cardiology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina; Medical faculty, University of Banja Luka, Bosnia and Herzegovina.

Objective: To investigate the level and causes of stress and the risk of onset of burnout syndrome among physicians employed at the Primary Health Care Centre, Banja Luka.

Subjects And Methods: Between March 1, 2018, and May 31, 2018 all physicians from the Primary Health Care Centre, Banja Luka were offered the following questionnaires to fill in: a socio-demographic questionnaire, a questionnaire for self-assessment of the level of stress and the Maslach Burnout Inventory for assessment of the risk of burnout syndrome.

Results: Out of 211 physicians, 85. Read More

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http://dx.doi.org/10.5644/ama2006-124.254DOI Listing

Knowledge and Attitudes of Sexually Transmitted Infections Among High School Students in Sarajevo.

Acta Med Acad 2019 Aug;48(2):147-158

Department of Forensic Medicine, School of Medicine University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Objective: The aim of the study was to evaluate knowledge and behavioural risks related to sexually transmitted infection (STIs) among high school students.

Methods: The cross sectional study was conducted among students aged 15-18 years old from two high schools in the Sarajevo Canton in the period from October 2017 to March 2018. An anonymous self-administered questionnaire was used. Read More

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http://dx.doi.org/10.5644/ama2006-124.253DOI Listing

Comparative Study of the Efficacy of the Lysozyme, Benzydamine and Chlorhexidine Oral Spray in the Treatment of Acute Tonsillopharyngitis - Results of a Pilot Study.

Acta Med Acad 2019 Aug;48(2):140-146

Bosnalijek JSC, Sarajevo, Bosnia and Herzegovina.

Objective: Lysozyme is a natural antimicrobial and immunomodulatory enzyme, which is produced as a host response to infectious agents. The objective of this study was to compare the efficacy and safety of lysozyme-based versus benzydamine and chlorhexidinebased oral spray in patients with an acute tonsillopharyngitis associated with a common cold.

Patients And Methods: A prospective twoarm pilot study (lysozyme/cetylpyridinium/lidocaine spray versus: benzydamine spray-arm 1; chlorhexidine/lidocaine spray-arm 2) was conducted in the primary health care unit. Read More

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http://dx.doi.org/10.5644/ama2006-124.252DOI Listing

Quantitative Analysis of CCL5 and ep300 in Periapical Inflammatory Lesions.

Acta Med Acad 2019 Aug;48(2):129-139

Center for Craniofacial Research, Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX 77054, USA.

Objectives: In silico bioinformatical analysis suggested that the expression of two genes, CCL5 (C-C Motif Chemokine Receptor 5) and ep300 (Histone acetyltransferase p300), could be used as potential new biomarkers in differentiation between periapical granulomas and radicular cysts. Thus, we hypothesized that gene expression of CCL5 and ep300 in periapical lesions would classify the lesions as either granuloma or cyst.

Materials: Patient samples (n=122) included 46 periapical granulomas, 38 radicular cysts and 38 healthy gingival samples as controls. Read More

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http://dx.doi.org/10.5644/ama2006-124.251DOI Listing

Dr. Anna Bayerová: The First Official Female Doctor in Bosnia and Herzegovina.

Acta Med Acad 2019 Apr;48(1):121-126

Department of Medical Sciences of the Academy of Sciences and Arts of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.

This biographical note details Anna Bayerová's (1853-1924) activities as the first female Austro-Hungarian health officer in 1878 to1918 occupied Bosnia and Herzegovina (BH). Anna Bayerová is known as a heroine of Czech feminism and the 'first Czech female physician', though she only practised in the Czech lands from 1913 to 1916. In 1891, Bayerová was enrolled as the first Austro-Hungarian female health officer and assigned to treat Muslim women in the district of Tuzla, Bosnia. Read More

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http://dx.doi.org/10.5644/ama2006-124.249DOI Listing
April 2019
4 Reads

TNS1-ALK Fusion in a Recurrent, Metastatic Uterine Mesenchymal Tumor Originally Diagnosed as Leiomyosarcoma.

Acta Med Acad 2019 Apr;48(1):116-120

The Angeles Clinic and Research Institute, Los Angeles, CA, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Objective: We report a female patient diagnosed with a leiomyosarcoma and who harbored a druggable target as identified by comprehensive genomic profiling in the course of clinical care.

Case Report: The patient progressed five years after curative intent surgery and adjuvant treatment. After failure of multiple lines of chemotherapy,she was enrolled in a trial of an ALK inhibitor based on comprehensive genomic profiling (CGP) identifying an TNS1-ALK fusion. Read More

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http://dx.doi.org/10.5644/ama2006-124.248DOI Listing
April 2019
2 Reads

Implementation and Outcomes of a Molecular Tumor Board at Herbert-Herman Cancer Center, Sparrow Hospital.

Acta Med Acad 2019 Apr;48(1):105-115

Herbert-Herman Cancer Center, Sparrow Hospital.

Objective: This paper describes our experience and outcomes from 54 cases presented to the (Molecular tumor board) MTB.

Methods: 54 Cases presented between July 2017 and April 2018 were included in this analysis. These patients had different types of cancers that had either failed standard therapy or were expected to fail and physicians were looking for future options for anticipated progression. Read More

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http://dx.doi.org/10.5644/ama2006-124.247DOI Listing
April 2019
2 Reads

Precision Medicine in Oncology Pharmacy Practice.

Acta Med Acad 2019 Apr;48(1):90-104

Ferris State University College of Pharmacy, PharmD Candidate.

The objective of this review is to provide an overview of the components, process and resources available to apply precision medicine strategies to drug therapy in cancer medicine, with an emphasis on oncology pharmacy practice. Precision medicine initiatives in oncology take into account individual variability in genes, environment and lifestyle factors. Genomic assays of patient tumors is now the standard of care in oncology and recommendations for targeted drug therapies are often formulated by interprofessional teams. Read More

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http://dx.doi.org/10.5644/ama2006-124.246DOI Listing
April 2019
3 Reads

Genomic-Based Therapy of Gynecologic Malignancies.

Authors:
Maurie Markman

Acta Med Acad 2019 Apr;48(1):84-89

Cancer Treatment Centers of America, Philadelphia, PA; Drexel University, College of Medicine, Philadelphia, PA.

This paper will review the current status of genomic-based therapy of gynecologic malignancies. The routine "standard-of-care" delivery of targeted therapeutics based on the presence of specific molecular biomarkers in the management of the gynecologic malignancies has been delayed compared to the substantial progress made in several other tumor types. However, relatively recently reported and rather robust phase 3 trial data have confirmed a potentially major role for PARP inhibitors as both active treatment and maintenance therapy of advanced ovarian cancer. Read More

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http://dx.doi.org/10.5644/ama2006-124.245DOI Listing
April 2019
2 Reads

Lung Cancer Genomics.

Authors:
Ankur R Parikh

Acta Med Acad 2019 Apr;48(1):78-83

Cancer Treatment Centers of America, Philadelphia, PA, USA.

The landscape of lung cancer treatment is rapidly evolving with the use of genomic testing which helps identify specific mutations or resistance mutations for these heterogenous tumors. Advanced lung cancer has a very poor prognosis but identifying other treatment options based on genomic profiling of the tumor can lead to improved outcomes. Evidence of benefit for genomic testing in lung cancer has now resulted in this test becoming part of national guidelines. Read More

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http://dx.doi.org/10.5644/ama2006-124.244DOI Listing
April 2019
9 Reads

Evolving Role of Genomics in Genitourinary Neoplasms.

Acta Med Acad 2019 Apr;48(1):68-77

Department of Medicine, Division of Hematology/Oncology, University of Virginia School of Medicine.

The aim of this article is to review the current role of genomic testing in the risk, prognosis, and treatment of genitourinary malignancies. The authors selected guidelines, publications, and abstracts relevant to the current and emerging role of genomics in genitourinary cancers. The risk of developing genitourinary cancer can be stratified based on genomic data. Read More

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http://dx.doi.org/10.5644/ama2006-124.243DOI Listing
April 2019
3 Reads

Multiple Myeloma Genomics - A Concise Review.

Acta Med Acad 2019 Apr;48(1):57-67

Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

The aim of this review is to summarize the current knowledge of genomic information in multiple myeloma. Multiple myeloma is a genetically complex plasma cell neoplasm that evolves from pre-malignant stages following genomic evolution leading to the proliferation of malignant plasma cells and the production of monoclonal immunoglobulin. The outcomes of patients with myeloma have dramatically improved over the past decade with the introduction of novel agents. Read More

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http://dx.doi.org/10.5644/ama2006-124.242DOI Listing
April 2019
4 Reads

Laboratory Work-Up of Chronic B-Cell Lymphoid Malignancies - A Value-Based Approach.

Acta Med Acad 2019 Apr;48(1):45-56

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester MN.

The aim of study was to summarize recent developments in laboratory work-up of lymphomas and discuss their clinical relevance. Diagnosis of lymphoma requires tissue biopsy with adequate work-up by pathologists. Recent developments in laboratory testing have raised the bar for establishing the diagnosis: more and more testing seems to be required, while the lines between research and clinical practice are being blurred. Read More

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http://dx.doi.org/10.5644/ama2006-124.241DOI Listing
April 2019
3 Reads

Advances in Acute Myeloid Leukemia Genomics, Where Do We Stand in 2018?

Acta Med Acad 2019 Apr;48(1):35-44

Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.

The aim of this review is to summarize the data on commonly mutated genes and genomic pathways in acute myeloid leukemia (AML) with a focus on recently approved targeted therapies. AML is a heterogeneous disease with recurrent cytogenetic and genomic abnormalities that define the disease biology and pathogenesis. Classification of the disease categories and their prognostication was updated in the past 2 years to reflect the most recent advances in understanding the complex disease biology of AML. Read More

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http://dx.doi.org/10.5644/ama2006-124.240DOI Listing
April 2019
2 Reads

Prospective Validation of a Genomic Assay in Breast Cancer: The 70-gene MammaPrint Assay and the MINDACT Trial.

Acta Med Acad 2019 Apr;48(1):18-34

Herbert-Herman Cancer Center, Lansing, MI.

MammaPrint was the first genomic assay in breast cancer to be validated with a prospective randomized trial, the MINDACT trial. The 70 gene MammaPrint assay was developed to determine the risk of distant metastasis in early stage breast cancer through gene expression analysis and was the first FDA cleared genomic assay for breast cancer. The assay identifies primary breast cancers likely to metastasize within the first five years of diagnosis and has clinical utility for helping to determine the expected benefit from adjuvant chemotherapy. Read More

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http://dx.doi.org/10.5644/ama2006-124.239DOI Listing
April 2019
2 Reads

Changing Landscape of Clinical-Genomic Oncology Practice.

Acta Med Acad 2019 Apr;48(1):6-17

Clinical Trials and Precision Medicine Dept., Herbert Herman Cancer Center, Sparrow Hospital, Lansing System, MI, USA.

The current paper discusses the use of genomics in the context of the changing landscape of clinical practice and modern medicine. Medical practice has shifted considerably over the past few decades, from empirical to evidence-based to personalized medicine, and the transition from reliance on observation to measureable parameters. Scientific innovation is required to collect an ever-increasing number and variety of data points and sophisticated analyses capable of distilling vast datasets into meaningful information. Read More

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http://dx.doi.org/10.5644/ama2006-124.238DOI Listing
April 2019
2 Reads

Genomics in Hematology and Oncology Practice.

Authors:
Gordan Srkalovic

Acta Med Acad 2019 Apr;48(1):1-5

Herbert-Herman Cancer Center, Sparrow Hospital System, Lansing, MI, USA.

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http://dx.doi.org/10.5644/ama2006-124.237DOI Listing
April 2019
1 Read

Why Hippocrates? A Clash Between Avarice and Morality in Ancient Greek Medical Ethics that Still Resounds.

Acta Med Acad 2018 Nov;47(2):211-212

History of Medicine, Anatomy Department, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

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http://dx.doi.org/10.5644/ama2006-124.235DOI Listing
November 2018
2 Reads

Looking Forward to the New Medical School in Croatia.

Authors:
Tomislav Franić

Acta Med Acad 2018 Nov;47(2):209-210

Medical School University of Split, Croatia.

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http://dx.doi.org/10.5644/ama2006-124.234DOI Listing
November 2018
2 Reads

Multiple Abnormalities in the Skull of a Prostitute. An Autopsy Report (1900).

Acta Med Acad 2018 Nov;47(2):204-208

Department of Molecular Medicine, Unit of History of Medicine, Sapienza University of Rome, Italy.

Objective: The study presents and comments on the publication of an autopsy report.

Case Report: In 1900 De Blasio published an article entitled "Multiple abnormalities in a prostitute's skull" in the "Journal of Psychiatry, Criminal Anthropology and related sciences". In this work De Blasio related anomalies at the cranial level to the presence of mental pathologies. Read More

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http://dx.doi.org/10.5644/ama2006-124.233DOI Listing
November 2018
4 Reads

A Rare Branching Pattern of a Middle Mesenteric Artery Supplying the Head of the Pancreas and the Transverse Colon.

Acta Med Acad 2018 Nov;47(2):199-203

Department of Anatomy, Medical School, National and Kapodistrian University of Athens, Greece.

Objective: The appearance of a middle mesenteric artery is a rare branching variation, with an incidence lower than 0.1%. Our case reports such an anatomical artery pattern which was discovered in a male Caucasian cadaver during routine educational dissection. Read More

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http://dx.doi.org/10.5644/ama2006-124.232DOI Listing
November 2018
3 Reads

Relapsing Tumefactive Demyelination: A Case Report.

Acta Med Acad 2018 Nov;47(2):193-198

Neurology Clinic, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.

Objective: We present a case of relapsing tumefactive demyelination in a young female patient, that posed a real diagnostic challenge, with a heterogeneous clinical picture, atypical for multiple sclerosis (MS) presentation, and neuroradiological manifestations with a high suspicion of neoplastic diseases.

Case Report: An 18-year old female patient presented to our Neurosurgical Out-patients' Clinic with symptoms atypical for multiple sclerosis, unremarkable neurological deficit, one tumefactive lesion on MRI, followed by relapse and another two lesions within a period of six months. We decided to perform biopsy of the tumefactive lesion with compressive effect. Read More

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http://dx.doi.org/10.5644/ama2006-124.231DOI Listing
November 2018
5 Reads

Non-Recurrent Laryngeal Nerve and Concurrent Vascular Variants: A Review.

Acta Med Acad 2018 Nov;47(2):186-192

Department of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Objective: The purpose of this paper is to review the current data on the coexistence of non-recurrent laryngeal nerve (RLN) and vascular variations.

Methods: A systematic literature search was conducted on MEDLINE for case reports, original articles and reviews regarding the presence of non-RLN and coexisting vascular variants.

Results: From the literature search, 104 cases of non-RLN with confirmed vascular variants were reported. Read More

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http://dx.doi.org/10.5644/ama2006-124.230DOI Listing
November 2018
4 Reads

Evaluation of Physical Parameters of Novel Licorice Varnish Versus Fluoride and Combination Varnish: An In-Vitro Study.

Acta Med Acad 2018 Nov;47(2):176-185

KLE Dr Prabhakar Kore Basic Science Research Centre, KLE Academy of Higher Education and Research, Belgaum, Karnataka, India.

Objectives: The aim of this study was to evaluate the physical properties of locally prepared Licorice varnish (LV), commercially available Fluoride varnish (FV) and a Combination of both Varnishes (CV).

Material And Methods: LV was prepared using authenticated licorice roots. Commercially available FV (Bifluorid 12) was used as a positive control and CV was prepared in six different concentrations of both varnishes. Read More

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http://dx.doi.org/10.5644/ama2006-124.229DOI Listing
November 2018
28 Reads

The Veil of Obscuration: Additional Radiographic Sign of Posterior Shoulder Dislocation.

Acta Med Acad 2018 Nov;47(2):165-175

Department of Radiology, University of Arizona Health Sciences Center, Tucson, Arizona, USA.

Objective: To describe a new radiographic sign, "veil of obscuration", associated with posterior glenohumeral joint (shoulder) dislocations and determine its incidence and validity compared to other known classic radiographic signs.

Methods: Four-year retrospective study identified 30 acute posterior shoulder dislocation patients. Radiographs reviewed in consensus by 2 musculoskeletal radiologists for the "veil of obscuration", seen on AP shoulder radiographs and representing a comminuted fracture of the lesser tuberosity projecting over the humeral head or glenohumeral joint. Read More

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http://dx.doi.org/10.5644/ama2006-124.228DOI Listing
November 2018
39 Reads

Depressive Symptoms Among Sarajevo University Students: Prevalence and Socio-Demographic Correlations.

Acta Med Acad 2018 Nov;47(2):155-164

Department of Public Health, Faculty of Medicine, University of Sarajevo.

Objectives: The aim of this research was to detect the presence of depressive symptoms among the student population at a Faculty of Medicine, as well to determine the correlation between the socio-demographic characteristics and students' lifestyle and depressive symptoms.

Subjects And Methods: Of 800 students enrolled and asked to participate, 412 responded to the survey. The study included students from all 6 years of studies. Read More

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http://dx.doi.org/10.5644/ama2006-124.227DOI Listing
November 2018
3 Reads

The Influence of Gender on the Cortical Width of the Lower Border of the Mandible and the Mandibular Cortical Index.

Acta Med Acad 2018 Nov;47(2):149-154

Prosthetic Department of the School of Dental Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Objective: To evaluate the influence of gender on the mental index (MI) and the mandibular cortical index (MCI).

Methods: In this study, there were 120 subjects (43 male and 77 female subjects), who had undergone a dental panoramic radiograph examination for the needs of diagnosis and future treatment planning. MI and MCI were determined by orthopantomograph. Read More

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http://dx.doi.org/10.5644/ama2006-124.226DOI Listing
November 2018
7 Reads