2,393 results match your criteria Acta medica Okayama[Journal]


Erratum.

Authors:

Acta Med Okayama 2019 02;73(1):93

Erratum to"The Incidence of Desaturation during Anesthesia in Adult and Pediatric Patients: A Retrospective Study", which appeared in the October 2018 issue, Vol.72,No.5, pp467-478. Read More

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http://dx.doi.org/10.18926/AMO/56466DOI Listing
February 2019
1 Read

Erratum.

Authors:

Acta Med Okayama 2019 02;73(1):91

Erratum to "High-dose Dexamethasone Therapy as the Initial Treatment for Idiopathic Thrombocytopenic Purpura: Protocol for a Multicenter, Open-label, Single Arm Trial" Vol.72, No.2, pp197-201. Read More

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http://dx.doi.org/10.18926/AMO/56465DOI Listing
February 2019
1 Read

Conventional-dose Versus Half-dose Sulfamethoxazole-trimethoprim for the Prophylaxis of Pneumocystis Pneumonia in Patients with Systemic Rheumatic Disease: A Non-blind, Randomized Controlled Trial.

Acta Med Okayama 2019 Feb;73(1):85-89

Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.

Pneumocystis pneumonia (PCP) due to Pneumocystis jirovecii infection is the leading cause of fatal opportunistic infections in immunocompromised patients. We will determine whether a daily sulfamethoxazole-trimethoprim (SMX/TMP) dose of 200/40 mg was non-inferior to 400/80 mg for PCP prevention in patients with systemic rheumatic disease under immunosuppressive therapy. This is a randomized, open-label, multicenter controlled trial. Read More

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http://dx.doi.org/10.18926/AMO/56464DOI Listing
February 2019
1 Read

Comparison of Two Electrosurgical Modes for Endoscopic Submucosal Dissection of Superficial Colorectal Neoplasms: A Prospective Randomized Study.

Acta Med Okayama 2019 Feb;73(1):81-84

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,

Endoscopic submucosal dissection (ESD) is reportedly one of the standard treatment strategies for large superficial colorectal neoplasms in Japan because of its high en bloc resection rate. A few technical issues regarding ESD should be considered, one of which is the selection of the Endo-cut I mode versus the Swift-coagulation mode as the electrosurgical unit mode setting during submucosal dissection. We seek to determine which of these two modes is more suitable for submucosal dissections of colorectal tumors with regard to procedure time and safety. Read More

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http://dx.doi.org/10.18926/AMO/56463DOI Listing
February 2019

Flap Reconstruction for Esophageal Perforation Following Anterior Cervical Plate Fixation.

Acta Med Okayama 2019 Feb;73(1):77-80

Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. Read More

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http://dx.doi.org/10.18926/AMO/56462DOI Listing
February 2019
1 Read

Efficacy of Oral Care Provided by Interprofessional Collaboration for a Patient with Esophageal Cancer Associated with Post-polio Syndrome during Neoadjuvant Chemotherapy.

Acta Med Okayama 2019 Feb;73(1):71-76

Dental Hygienist Team, Division of Medical Technology, Okayama University Hospital, Okayama 700-8558, Japan.

Preoperative oral care is helpful to prevent postoperative complications in patients who are undergoing esophagectomy. Here, we report the case of an 81-year-old Japanese man with an upper limb disability caused by post-polio syndrome who was receiving neoadjuvant chemotherapy for esophageal cancer. He had poor oral health status and developed oral complications as a side effect of chemotherapy. Read More

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http://dx.doi.org/10.18926/AMO/56461DOI Listing
February 2019

Congenital Multiple Ocular Motor Nerve Palsy Complicated by Splitting of the Lateral Rectus Muscle.

Acta Med Okayama 2019 Feb;73(1):67-70

Okayama University Hospital, Okayama 700-8558,

We report a case of congenital multiple ocular motor nerve palsy combined with splitting of the lateral rectus muscle (LR). A 59-year-old Japanese female was investigated for worsening esotropia after corrective surgery. She presented with left hypertropia (35Δ) and esotropia (45-50Δ). Read More

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http://dx.doi.org/10.18926/AMO/56460DOI Listing
February 2019

Remission of Congenital Multi-system Type Langerhans Cell Histiocytosis with Chemotherapy.

Acta Med Okayama 2019 Feb;73(1):61-65

Department of Pediatrics, Okayama University Hospital, Okayama 700-8558, Japan.

Patients with multi-system (MS)-type langerhans cell histiocytosis (LCH) show poor outcomes, especially congenital MS LCH cases were shown in high mortality rate. We experienced a congenital case of MS LCH with high risk organs, who needed intensive respiratory support after birth. Even though intensive chemotherapy was discontinued, this patient's lung LCH lesions gradually became reduced and his respiratory condition recovered; therefore, we restarted and completed maintenance chemotherapy. Read More

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http://dx.doi.org/10.18926/AMO/56459DOI Listing
February 2019
2 Reads

Impact of Body Mass Index of Japanese Gallbladder Cancer Patients on their Postoperative Outcomes.

Acta Med Okayama 2019 Feb;73(1):51-59

Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama 700-8511,

 We investigated the relationship between body mass index (BMI) and postoperative outcomes in 450 gallbladder cancer patients in Japan. We collected patient information, including sex, age, underlying disease, BMI, stage, surgery method, postoperative time to discharge, and postoperative Medicare fees, from the Japanese administrative database associated with the Diagnosis Procedure Combination system. We classified patient BMIs as underweight (BMI<18. Read More

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http://dx.doi.org/10.18926/AMO/56458DOI Listing
February 2019
1 Read

Predictive Factors for Successful Vaccination Against Hepatitis B Surface Antigen in Patients Who Have Undergone Orthotopic Liver Transplantation.

Acta Med Okayama 2019 Feb;73(1):41-50

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. Read More

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http://dx.doi.org/10.18926/AMO/56457DOI Listing
February 2019
2 Reads

Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage.

Acta Med Okayama 2019 Feb;73(1):29-39

Department of Neurological Surgery, Kagawa University Faculty of Medicine, Miki, Kagawa 761-0793, Japan.

Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53. Read More

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http://dx.doi.org/10.18926/AMO/56456DOI Listing
February 2019

Clitoral Blood Flow Changes after Surgery with Tension-Free Vaginal Mesh for Pelvic Organ Prolapse.

Acta Med Okayama 2019 Feb;73(1):21-27

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. Read More

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http://dx.doi.org/10.18926/AMO/56455DOI Listing
February 2019
2 Reads

High-flow Nasal Cannula Versus Noninvasive ventilation for Postextubation Acute Respiratory Failure after Pediatric Cardiac Surgery.

Acta Med Okayama 2019 Feb;73(1):15-20

Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama 700-8558, Japan.

We compared the reintubation rate in children who received high-flow nasal cannula (HFNC) therapy to the rate in children who received noninvasive ventilation (NIV) therapy for acute respiratory failure (ARF) after cardiac surgery. This was a retrospective analysis of 35 children who received HFNC therapy for ARF after cardiac surgery in 2014-2015 (the HFNC group). We selected 35 children who had received NIV therapy for ARF after cardiac surgery in 2009-2012 as a control group. Read More

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http://dx.doi.org/10.18926/AMO/56454DOI Listing
February 2019
4 Reads

Reduction of Postoperative Pain by Addition of Intravenous Acetaminophen after Total Hip Arthroplasty: A Retrospective Cohort Study.

Acta Med Okayama 2019 Feb;73(1):7-14

Community Medical Support Institute, Faculty of Medicine, Saga University, Faculty of Medicine, Saga University, Saga 849-8501, Japan.

We evaluated the analgesic effects of multimodal pain control in which intravenous acetaminophen (IV APAP) was added to the standard protocol for Japanese patients who had undergone a total hip arthroplasty (THA). We performed a retrospective cohort study of 180 patients aged 66.4±10. Read More

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http://dx.doi.org/10.18926/AMO/56453DOI Listing
February 2019

The Role of Kallikrein-Related Peptidases in Atopic Dermatitis.

Authors:
Shin Morizane

Acta Med Okayama 2019 Feb;73(1):1-6

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,

Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Read More

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http://dx.doi.org/10.18926/AMO/56452DOI Listing
February 2019

Development of an Oropharyngeal Scope with an Integrated Tongue Depressor: NTOP2013 Study.

Acta Med Okayama 2018 Dec;72(6):611-614

Department of Artificial Organs Medical Device Creation, Tokyo Medical Center, Tokyo 152-8902,

The oropharynx is examined with a light source such as an electric light, a penlight, or a forehead mirror based on an acquired visual field using a tongue depressor. However, it is extremely difficult to obtain objective and reproducible images of tissue within the pharynx required in recent years with these methods, and insufficient progress in the examination tools has been made. There is an increasing need to develop a method for display during oropharyngeal examination. Read More

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http://dx.doi.org/10.18926/AMO/56381DOI Listing
December 2018
15 Reads

Burned-out Prostate Cancer ? Primary Metastatic Cancer Not Detected on Repeat Biopsy.

Acta Med Okayama 2018 Dec;72(6):605-609

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Read More

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http://dx.doi.org/10.18926/AMO/56380DOI Listing
December 2018
9 Reads

Salmonella Osteomyelitis of the Distal Tibia in a Healthy Woman.

Acta Med Okayama 2018 Dec;72(6):601-604

Department of Orthopedic Surgery, Kindai University Hospital, Osaka-Sayama, Osaka 589-8511,

Salmonella osteomyelitis is extremely rare; only a few cases have been reported in healthy adults. We describe a case of salmonella osteomyelitis in an otherwise healthy 20-year-old Japanese woman who presented with distal tibial pain. X-ray and magnetic resonance imaging showed a lesion suspected to be a bone cyst. Read More

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http://dx.doi.org/10.18926/AMO/56379DOI Listing
December 2018
7 Reads

A Case of Diffuse Esophageal Spasm Treated with Peroral Endoscopic Myotomy.

Acta Med Okayama 2018 Dec;72(6):595-600

Department of Gastroenterology and Hepatology, Okayama University Hospital, Okayama 700-8558,

The indications for peroral endoscopic myotomy (POEM) have been expanded to include diffuse esophageal spasm (DES). A 67-year-old Japanese man presented with a 4-year history of dysphagia. Endoscopy and upper gastrography revealed abnormal peristaltic movements involving interruption of normal peristalsis, and a diverticulum located at the 2 o'clock esophageal position. Read More

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http://dx.doi.org/10.18926/AMO/56378DOI Listing
December 2018
16 Reads

The Neutrophil to Lymphocyte Ratio Is Superior to Other Inflammation-Based Prognostic Scores in Predicting the Mortality of Patients with Pneumonia.

Acta Med Okayama 2018 Dec;72(6):591-593

Department of Anesthesiology, Osaka Medical College, Takatsuki, Osaka 569-8686,

A neutrophil-to-lymphocyte ratio (NLR) > 7 is reportedly an independent marker of mortality in patients with bacteremia. However, no studies have shown an association between inflammation-based prognostic scores (including the Glasgow Prognostic Score, the NLR, the platelet-to-lymphocyte ratio, the Prognostic Nutritional Index, and the Prognostic Index) and mortality in patients with pneumonia. We retrospectively examined the cases of 33 patients diagnosed with pneumonia who were treated in the ICU of Osaka Medical College Hospital between January 2014 and June 2016. Read More

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http://dx.doi.org/10.18926/AMO/56377DOI Listing
December 2018

Rotational and Varus Instability in Chronic Lateral Ankle Instability: In Vivo 3D Biomechanical Analysis.

Acta Med Okayama 2018 Dec;72(6):583-589

Department of Orthopedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.

We retrospectively evaluated the altered biomechanics of the talus in 15 adult patients (7 males, 8 females) with chronic lateral ankle instability when the ankle joint moved actively from full dorsiflexion to full plantarflexion under a non-weight bearing condition. CT images were taken for the unstable ankle and the contralateral normal (control) ankle. Three-dimensional surface models of both ankle joints were reconstructed from the CT data, and we used a computer simulation program to compare both ankle motions of inversion/eversion in the coronal plane, plantarflexion/dorsiflexion in the sagittal plane, and internal rotation/external rotation in the axial plane. Read More

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http://dx.doi.org/10.18926/AMO/56376DOI Listing
December 2018
18 Reads

Computed Tomography Findings for Diagnosing Follicular Thyroid Neoplasms.

Acta Med Okayama 2018 Dec;72(6):577-581

Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,

Since no diagnostic method has been established to distinguish follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA), surgery has been the only way to reach a diagnosis of follicular neoplasm. Here we investigated the computed tomography (CT) features of follicular neoplasms, toward the goal of being able to identify specific CT features allowing the preoperative differentiation of FTC from FTA. We retrospectively analyzed the cases of 205 patients who underwent preoperative CT of the neck and were histopathologically diagnosed with FTC (n=31) or FTA (n=174) after surgery between January 2002 and June 2016 at several hospitals in Japan. Read More

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http://dx.doi.org/10.18926/AMO/56375DOI Listing
December 2018
2 Reads

Prognostic Factors for Pediatric Living Donor Liver Transplantation: Impact of Zero-mortality Transplant for Cholestatic Diseases.

Acta Med Okayama 2018 Dec;72(6):567-576

Hepato-Biliary and Pancreatic Surgery, Okayama University Hospital, Okayama 700-8558,

Living donor liver transplantation (LDLT) is the final therapeutic arm for pediatric end-stage liver diseases. Toward the goal of achieving further improvement in LDLT survival, we investigated factors affecting recipient survival. We evaluated the prognostic factors of 60 pediatric recipients (< 16 years old) who underwent LDLT between 1997 and 2015. Read More

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http://dx.doi.org/10.18926/AMO/56374DOI Listing
December 2018
1 Read

Difference between the Right and Left Phrenic Nerve Conduction Times, Latency, and Amplitude.

Acta Med Okayama 2018 Dec;72(6):563-566

Department of Rehabilitation Medicine, Okayama University Hospital, Okayama 700-8558,

We studied phrenic nerve conduction times in 90 phrenic nerves of 45 normal subjects. The phrenic nerve was stimulated at the posterior border of the sternomastoid muscle in the supraclavicular fossa, just above the clavicle, with bipolar surface electrodes. For recording, positive and negative electrodes were placed on the xiphoid process and at the eighth intercostal bone-cartilage transition, respectively. Read More

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http://dx.doi.org/10.18926/AMO/56373DOI Listing
December 2018

Changes in Serum Biochemical Markers in Relation to Chief Complaints and Aging in General Medicine.

Acta Med Okayama 2018 Dec;72(6):553-562

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

To clarify potential relationships between chief complaints of patients and laboratory data with a focus on aging-related changes, we retrospectively analyzed the data of 843 patients who visited a general medicine department for the first time. Their chief complaints were classified into 8 major symptoms: visceral pain, somatic pain, fever, cough, dizziness, fatigue, appetite loss, and edema. We compared the laboratory data obtained from the patients with complaints with the data of symptom-free (control) patients. Read More

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http://dx.doi.org/10.18926/AMO/56372DOI Listing
December 2018

Association between the Critical Shoulder Angle and Rotator Cuff Tears in Japan.

Acta Med Okayama 2018 Dec;72(6):547-551

Department of Rehabilitation, Machida Orthopaedics, Ino, Kochi 781-2123,

Distinct anatomic variants of the scapula such as the critical shoulder angle (CSA) were found to be associated with rotator cuff tears (RCTs), but it is unclear whether the CSA is a risk factor in Japanese. Here we sought to determine whether the CSA is associated with RCTs in a Japanese population, and whether the CSA is a more useful parameter than the conventionally used parameters. Our RCT group and non-RCT group each consisted of 54 consecutive cases. Read More

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http://dx.doi.org/10.18926/AMO/56371DOI Listing
December 2018
2 Reads

Zerobot®: A Remote-controlled Robot for Needle Insertion in CT-guided Interventional Radiology Developed at Okayama University.

Acta Med Okayama 2018 Dec;72(6):539-546

Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,

Since 2012, we have been developing a remote-controlled robotic system (Zerobot®) for needle insertion during computed tomography (CT)-guided interventional procedures, such as ablation, biopsy, and drainage. The system was designed via a collaboration between the medical and engineering departments at Okayama University, including various risk control features. It consists of a robot with 6 degrees of freedom that is manipulated using an operation interface to perform needle insertions under CT-guidance. Read More

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http://dx.doi.org/10.18926/AMO/56370DOI Listing
December 2018

Effect of Zinc Acetate Dihydrate (NobelzinR) Treatment on Anemia and Taste Disorders in Patients with Chronic Kidney Disease with Hypozincemia.

Acta Med Okayama 2018 Oct;72(5):535-538

Department of Nephrology, Juntendo University Faculty of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.

Some patients with chronic kidney disease (CKD) receiving hemodialysis develop erythropoietin-resistant anemia, possibly due to zinc deficiency. The frequency of zinc deficiency in CKD (stages 1-5 and 5D) and CKD improvement via zinc supplementation are not completely verified. Here 500 CKD patients (Stage 1/2, n=100; Stage 3, n=100; Stage 4, n=100, Stage n=5, 100; Stage 5D, n=100) will be recruited to determine the frequency of serum zinc deficiency at each CKD stage. Read More

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http://dx.doi.org/10.18926/AMO/56254DOI Listing
October 2018
4 Reads

Sacral Stress Fracture Complicated by L5 Radiculopathy in a Patient with Rheumatoid Arthritis.

Acta Med Okayama 2018 Oct;72(5):531-534

Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

A 60-year-old Japanese woman with severe osteoporosis presented with a history of right buttock pain and right lateral lower leg pain in an L5 distribution. She had been treated with methotrexate and methylprednisolone for rheumatoid arthritis (RA) and interstitial pneumonia. Computed tomography demonstrated a sacral stress fracture in the right sacral ala. Read More

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http://ousar.lib.okayama-u.ac.jp/56253
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http://dx.doi.org/10.18926/AMO/56253DOI Listing
October 2018
15 Reads

Rapidly Destructive Arthrosis of Bilateral Humeral Heads Caused by Subchondral Insufficiency Fracture.

Acta Med Okayama 2018 Oct;72(5):525-530

Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

The bilateral shoulder pain of an 81-year-old Japanese woman due to falls persisted despite celecoxib treatment, and plain X-rays later showed bilateral collapsed humeral heads. After ruling out osteoarthritis, infectious arthritis, crystal-induced arthritis, neuropathic arthropathy, and osteonecrosis, we diagnosed bilateral shoulder joint rapidly destructive arthrosis (RDA). Lumbar bone mineral density showed very low T-score (-4. Read More

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http://dx.doi.org/10.18926/AMO/56252DOI Listing
October 2018
17 Reads

Recurrent Meningitis in an 11-year-old Girl with a Petrous Apex Cystic Lesion.

Acta Med Okayama 2018 Oct;72(5):519-523

Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Cases of recurrent meningitis in elderly patients with a spontaneous cerebrospinal fistula have been reported, and in some of these patients, cystic lesions were thought to be the underlying cause. We report a case of recurrent meningitis in an 11-year-old Japanese girl with an arachnoid cyst in the petrous apex. Pulsation of the cystic lesion was thought to cause bone erosion, leading to the formation of a fistula. Read More

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http://ousar.lib.okayama-u.ac.jp/56251
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http://dx.doi.org/10.18926/AMO/56251DOI Listing
October 2018
19 Reads

Long-term Remission of Hepatitis-associated Aplastic Anemia Possibly due to Immunosuppressive Therapy after Liver Transplantation.

Acta Med Okayama 2018 Oct;72(5):515-518

Department of Pediatrics, Okayama University Hospital, Okayama 700-8558, Japan.

Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living-donor liver transplantation for fulminant hepatitis. Read More

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http://dx.doi.org/10.18926/AMO/56250DOI Listing
October 2018
1 Read

Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer.

Acta Med Okayama 2018 Oct;72(5):507-513

Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

To clarify the relationship between dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) after surgery in cases of non-small cell lung cancer (NSCLC) treated with induction concurrent chemoradiotherapy (CCRT). Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 2.0 Gy fractions once daily for a total of 46 Gy) before surgery were reviewed. Read More

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http://dx.doi.org/10.18926/AMO/56249DOI Listing
October 2018
15 Reads

Composition of Cell Clusters in Torn Menisci and Their Extracellular Matrix Components.

Acta Med Okayama 2018 Oct;72(5):499-506

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Cell clusters, or groups of cells sharing a single chondron-like structure, are frequently found in degenerated areas of the osteoarthritic (OA) meniscus. However, little is known about these meniscal clusters in humans. The aim of our study was to determine the composition of the extracellular matrix deposition around cell clusters in human OA menisci. Read More

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http://dx.doi.org/10.18926/AMO/56248DOI Listing
October 2018
3 Reads

Pullout Repair of the Medial Meniscus Posterior Root Tear Reduces Proton Density-Weighted Imaging Signal Intensity of the Medial Meniscus.

Acta Med Okayama 2018 Oct;72(5):493-498

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Medial meniscus (MM) posterior root tear (PRT) results in joint overloading and degenerative changes in the knee. MM root repair is recommended to prevent subsequent cartilage degeneration following MMPRT. Favorable clinical outcomes have been reported after transtibial pullout repair of MMPRT. Read More

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http://dx.doi.org/10.18926/AMO/56247DOI Listing
October 2018
2 Reads

Differences in the Stability and Amount of Postoperative Exodrift with Age after Unilateral Lateral Rectus Muscle Recession and Medial Rectus Muscle Resection of Intermittent Exotropia.

Acta Med Okayama 2018 Oct;72(5):487-492

Department of Ophthalmology, Okayama University Hospital, Okayama 700-8558, Japan.

We investigated variances in the stability and amount of postoperative exodrift among age groups of intermittent exotropia (XPT) patients who underwent unilateral lateral rectus muscle recession and medial rectus muscle resection. We analyzed the cases of 110 consecutive patients who underwent the surgery in 2004-2011, dividing the patients into groups by their age at surgery: <10, 10-19, and ≥20 years. We performed a regression analysis (dependent variable: postoperative exodrift (°); independent variable: number of days post-surgery) using the formula of curve lines. Read More

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http://dx.doi.org/10.18926/AMO/56246DOI Listing
October 2018

Application of Single Prolonged Stress Induces Post-traumatic Stress Disorder-like Characteristics in Mice.

Acta Med Okayama 2018 Oct;72(5):479-485

Physiology and Pharmacology, School of Health and Social Services, Saitama Prefectural University, Koshigaya, Saitama 343-8540, Japan.

We tried to clarify the applicability of a single prolonged stress (SPS) protocol as post-traumatic stress disorder (PTSD) model in mice. To investigate PTSD pathophysiology, we conducted hypothalamo-pituitary-adrenal (HPA) negative feedback testing at 1, 4, 8 and 12 weeks after the SPS by administrating a dexamethasone (DEX) suppression test. The SPS induced over-suppression of the HPA system by DEX treatment at 8 and 12 weeks. Read More

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http://dx.doi.org/10.18926/AMO/56245DOI Listing
October 2018
2 Reads

The Incidence of Desaturation during Anesthesia in Adult and Pediatric Patients: A Retrospective Study.

Acta Med Okayama 2018 10;72(5):467-478

Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

We investigated the incidence of desaturation during general anesthesia in preoperatively hypoxic (< 92%), and nonhypoxic (≥ 92%) pediatric (n=1,090) and adult (n=5,138) patients. We plotted the patients' SpO2 value time-courses and assessed desaturation in 6,228 patients. The crude overall incidence (95%CI) for desaturation was 11. Read More

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http://dx.doi.org/10.18926/AMO/56244DOI Listing
October 2018

Quercetin Attenuates Neuropathic Pain in Rats with Spared Nerve Injury.

Acta Med Okayama 2018 Oct;72(5):457-465

Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Quercetin is a flavonoid widely found in plants and marketed to the public as a supplement. Several studies have reported its effect on glial cells. This study aimed to examine the effect of quercetin on the development of neuropathic pain and the underlying mechanism in a spared nerve injury (SNI) rat model. Read More

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http://ousar.lib.okayama-u.ac.jp/56243
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http://dx.doi.org/10.18926/AMO/56243DOI Listing
October 2018
8 Reads

Clinical Characteristics of Febrile Outpatients : Possible Involvement of Thyroid Dysfunction in Febrile Tachycardia.

Acta Med Okayama 2018 Oct;72(5):447-456

Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Read More

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http://ousar.lib.okayama-u.ac.jp/56242
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http://dx.doi.org/10.18926/AMO/56242DOI Listing
October 2018
18 Reads

An Open-label Single-arm Trial of a Novel Extramedullary Guide Coordinated with 3D Surgical Assistive Software for Total Knee Arthroplasty.

Acta Med Okayama 2018 Aug;72(4):441-445

Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Nagoya 460-0001,

There is no assistive device for extramedullary surgery coordinated with 3D surgical assistive software for the total knee arthroplasty (TKA). We developed a novel extramedullary universal guide coordinated with 3D surgical assistive software and a novel extramedullary patient-specific assistive guide for the placement of femoral components by referring to an area not affected by cartilage or bone spurs, and filed a patent application. In this study, we visualize and reconstruct the total alignment of the lower extremity in TKA using these surgical devices, and validate their precision. Read More

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http://ousar.lib.okayama-u.ac.jp/56186
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http://dx.doi.org/10.18926/AMO/56186DOI Listing
August 2018
8 Reads

The Effect of Interim FDG-PET-guided Response-Adapted Therapy in Pediatric Patients with Hodgkin's Lymphoma (HL-14) : Protocol for a Phase II Study.

Acta Med Okayama 2018 Aug;72(4):437-440

Department of Pediatrics, Graduate School of Medical Sciences Kyushu University, Fukuoka 812-8582,

This trial enrolls patients with untreated Hodgkin's lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates. Read More

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http://dx.doi.org/10.18926/AMO/56185DOI Listing
August 2018
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A Phase I/II Study of Crizotinib for Recurrent or Refractory Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma and a Phase I Study of Crizotinib for Recurrent or Refractory Neuroblastoma : Study Protocol for a Multicenter Single-arm Open-label Trial.

Acta Med Okayama 2018 Aug;72(4):431-436

Department of Pediatrics, Nagoya Medical Center, Nagoya 460-0001,

Crizotinib is an inhibitor of multiple tyrosine kinases, including the anaplastic lymphoma kinase (ALK). Responses to crizotinib have also been reported in patients with ALK-positive anaplastic large-cell lymphoma (ALCL) and solid tumors with ALK-mutation, including neuroblastoma. Optimal treatment for patients with recurrent or refractory ALK-positive ALCL and neuroblastoma has not been established. Read More

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http://dx.doi.org/10.18926/AMO/56184DOI Listing
August 2018
15 Reads

Phase II Clinical Trial for Newly Diagnosed Children and Adolescents with Localized Lymphoblastic Lymphoma (Japanese Leukemia/Lymphoma Study Group Trial LLB-NHL03) : Study Protocol for Nationwide Multicenter Trial.

Acta Med Okayama 2018 Aug;72(4):427-430

Department of Pediatrics, Nagoya Medical Center, Nagoya 460-0001,

Pediatric patients with lymphoblastic lymphoma are generally treated using the Berlin-Frankfurt-Munster (BFM) 90 protocol, which is the standard treatment strategy for pediatric acute lymphoblastic leukemia, and have a favorable outcome. However, this intense regimen includes high total doses of anthracycline and alkylating agents, and is known to cause late complications. We therefore planned a clinical trial to examine the efficacy and safety of a modified BFM regimen. Read More

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http://ousar.lib.okayama-u.ac.jp/56183
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http://dx.doi.org/10.18926/AMO/56183DOI Listing
August 2018
10 Reads

Study Design of a Phase II Clinical Trial to Assess the Efficacy and Safety of Eperisone in Japanese Type 2 Diabetes Patients with Risk and Non-risk Alleles of CDKAL1.

Acta Med Okayama 2018 Aug;72(4):423-426

Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.

Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. Read More

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http://dx.doi.org/10.18926/AMO/56182DOI Listing
August 2018
1 Read

Microseizures Induced by Topiramate.

Acta Med Okayama 2018 Aug;72(4):419-422

Department of Pediatrics, Tokiwa-Kure Facilities for Persons with Severe Motor and Intellectual Disabilities, Kure, Hiroshima 737-0024,

A 22-year-old Japanese male with trisomy 21 was diagnosed with West syndrome at 4 months old. After the suppression of epileptic spasms using adrenocorticotropic hormone therapy, he had complex partial seizures and bilateral frontal epileptic discharges on EEG. Although the introduction of topiramate (TPM) decreased the seizures during wakefulness, frequent episodes of brief eye-opening appeared during sleep while the patient was taking TPM (400 mg/day). Read More

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http://dx.doi.org/10.18926/AMO/56181DOI Listing
August 2018
18 Reads

Development of Gait Rehabilitation System Capable of Assisting Pelvic Movement of Normal Walking.

Acta Med Okayama 2018 Aug;72(4):407-417

Gait rehabilitation training with robotic exoskeleton is drawing attention as a method for more advanced gait rehabilitation training. However, most of the rehabilitation robots are mainly focused on locomotion training in the sagittal plane. This study introduces a novel gait rehabilitation system with actuated pelvic motion to generate natural gait motion. Read More

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http://dx.doi.org/10.18926/AMO/56180DOI Listing
August 2018
3 Reads

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy.

Acta Med Okayama 2018 Aug;72(4):401-406

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. Read More

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http://ousar.lib.okayama-u.ac.jp/56178
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http://dx.doi.org/10.18926/AMO/56178DOI Listing
August 2018
20 Reads

Relationship between Sedentary Behavior and Health-Related Quality of Life in Patients on Chronic Hemodialysis.

Acta Med Okayama 2018 Aug;72(4):395-400

Department of Hygiene, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793,

We explored the relationship between sedentary behavior and the health-related quality of life (HRQOL) in patients on chronic hemodialysis. A total of 60 outpatients, aged 71.1±12. Read More

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http://dx.doi.org/10.18926/AMO/56177DOI Listing
August 2018
1 Read

Women with Recurrent Pregnancy Loss : Their Psychology During Late Pregnancy and the Supportive Behavior of Their Partners.

Acta Med Okayama 2018 Aug;72(4):387-394

Department of Nursing, Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193,

To elucidate the psychiatric characteristics of mothers and the supportive behavior of their partners during late pregnancy, 131 mothers who gave birth at 2 general hospitals in City A between August 2009 and September 2010 (control group: n=90; recurrent pregnancy loss (RPL) group: n=41) completed a self-administered questionnaire on four separate occasions: during late pregnancy, during hospitalization, at 1-month postpartum, and at 3-months postpartum. The RPL group had significantly (p=0.03) lower anxiety regarding potential change in their appearance than the controls, but were more likely to worry about losing their baby (58% vs. Read More

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http://dx.doi.org/10.18926/AMO/56176DOI Listing
August 2018
15 Reads