1,397 results match your criteria Acta medica Iranica[Journal]


"Eye of the Tiger" in a Non-Responsive Neuropsychiatric Patient: A Case Report.

Acta Med Iran 2018 Jan;56(1):71-73

Student's Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Hallervorden-Spatz syndrome is a rare neurodegenerative disorder with hereditary properties. It usually occurs in young adolescents with extrapyramidal symptoms besides disturbed mental function. In this study, we present a 23-year-old neuropsychiatric patient who primarily misdiagnosed to have conversion disorder. Read More

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January 2018
7 Reads

A Road to the Heart From Uterine Closet: A Case Report.

Acta Med Iran 2018 Jan;56(1):67-70

Department of Cardiac Surgery, Kermanshah University of Sciences, Imam Ali Hospital, Kermanshah, Iran.

Angiosarcomas of the uterine is a malignant and poor prognostic tumor and can either be a primary sarcoma or arising secondary to radiotherapy of a more complex tumor. Primary uterine angiosarcomas are exceptional and probably arise from embryonic vascular remnants, teratoma or from the rich uterine vasculature. We reported a rare case of primary angiosarcoma of uterine that at the time of diagnosis presented with sign and symptom of local and distant metastasis. Read More

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January 2018
6 Reads

A Case of Kleine-Levin Syndrome: Diagnostic and Therapeutic Challenge.

Acta Med Iran 2018 Jan;56(1):62-66

Department of Neurology, Clinical Hospital Center Split, Split, Croatia.

Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hyper sexuality. Etiology is unknown, and there is no specific clinical or imaging test for this syndrome even though the illness has well-defined clinical features. Also, there is no effective treatment for KLS. Read More

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January 2018
3 Reads

Predictive Value of Braden Risk Factors in Pressure Ulcers of Outpatients With Spinal Cord Injury.

Acta Med Iran 2018 Jan;56(1):56-61

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Pressure Ulcers (PUs) remain among the most common complications after traumatic spinal cord Injuries (SCIs). The main goal of risk factor assessment with different tools has been to provisionally estimate the chance of developing pressure ulcers in patients with Spinal Cord Injury (SCI). Braden tool has been of good predictive value and most commonly employed in hospital communities for risk assessment of pressure sore development. Read More

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January 2018
2 Reads

Assessing the Phenylketonuria Screening Program in Newborns, Iran 2015-2016.

Acta Med Iran 2018 Jan;56(1):49-55

Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. AND Department of Community Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Phenylketonuria is one of the most important congenital disorders and an autosomal recessive metabolic disease that can cause irreversible brain damages, mental retardation, and cognitive disorders if left untreated. In order to reduce the genetic abnormalities caused by this metabolic disease, screening programs are implemented. The quality of the program must be properly assessed to achieve the objectives of this program if promoting children's health is of concern. Read More

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January 2018
2 Reads

The Follow-Up Role of the Vestibular Evoked Myogenic Potential Test in Meniere's Disease.

Acta Med Iran 2018 Jan;56(1):43-48

Department of Otorhinolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Despite some proposed roles for the diagnostic impact of the cervical vestibular evoked myogenic potential test in the patients with Meniere's disease, the role of this test as an objective instrument in following up the patients with Meniere's disease who underwent. Intratympanic steroid injection is not cleared. In a prospective study, thirty-one adult patients with definite one-sided Meniere's disease with vertigo as main complaint refractory to medical treatments for three months, were selected. Read More

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January 2018
5 Reads

Gonadotropin Regulation of Retinoic Acid Activity in the Testis.

Acta Med Iran 2018 Jan;56(1):34-42

Institute for Family Health, Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Initiation of spermatogenesis in primates is triggered at puberty by an increase in gonadotropins; i.e., follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Read More

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January 2018
1 Read

Wharton's Jelly Derived-Mesenchymal Stem Cells: Isolation and Characterization.

Acta Med Iran 2018 Jan;56(1):28-33

School of Traditional Medicine, Iran University of Medical Sciences, Tehran, Iran. AND Department of Molecular Medicine, Sapienza University, Rome, Italy.

Wharton`s jelly-derived mesenchymal stem cells (WJ-MSCs), have a high proliferation valency and they do not produce teratogen or carcinogen after subsequent transplantation. They are known as regenerative medicine. Thus more research is needed on the isolation and characterization of mesenchymal stem cells. Read More

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January 2018
12 Reads

Promoter Hypermethylation of the Eyes Absent 4 Gene is a Tumor-Specific Epigenetic Biomarker in Iranian Colorectal Cancer Patients.

Acta Med Iran 2018 Jan;56(1):21-27

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AND Cancer Genetics Research Unit, Reza Radiotherapy and Oncology Center, Mashhad, Iran.

The aim of this study was to investigate whether hypermethylation of Eyes Absent 4 (EYA4) is also implicated in Iranian Colorectal Cancer (CRC) patients or not. From fresh frozen tissues, samples from 38 paired (cancer and normal) CRC tissue specimens were used in this study, the DNA was isolated, sodium bisulfite treated and analyzed by methylation-specific polymerase (MSP) chain reaction using primers specific for unmethylated or methylated promoter sequences of the EYA4 gene. We also analyzed EYA4 mRNA expression using real time RT-PCR. Read More

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January 2018
1 Read

Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice.

Acta Med Iran 2018 Jan;56(1):14-20

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies. In the present experiment, the possible effect of cromakalim on the convulsion and death induced by OPs and carbamates was studied in mice. Read More

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January 2018
6 Reads

Evaluation of Chronic Losartan Treatment Effect on Cardiac Chronotropic Dysfunction in Biliary Cirrhotic Rats.

Acta Med Iran 2018 Jan;56(1):4-13

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Cirrhosis is associated with cardiac chronotropic and inotropic dysfunction which is known as cirrhotic cardiomyopathy. Cardiac responsiveness to adrenergic stimulation is impaired in cirrhosis. Moreover, there is vagal nerve dysfunction which is related to neuromodulatory dysfunction of the angiotensin II in the cirrhosis. Read More

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January 2018
2 Reads

Universal Scientific Education and Research Network (USERN): Twinkling Stars Unite to Make the World Glow.

Authors:
Nima Rezaei

Acta Med Iran 2018 Jan;56(1):1-3

Universal Scientific Education and Research Network (USERN), Tehran, Iran. AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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January 2018

Paraplegia After Off-Pump Coronary Artery By-Pass Grafting.

Acta Med Iran 2017 Dec;55(12):807-811

Department of Cardiovasculary Surgery, Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Paraplegia is an exceedingly rare neurologic complication after off-pump coronary artery bypass graft (OPCAB) surgery commonly caused by spinal cord ischemia (SCI). SCI is not a well unknown clinical phenomenon in the postoperative course. SCI has been reported after noncardiac surgery in otherwise healthy subjects in whom only one risks factor i. Read More

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December 2017
1 Read

Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews.

Acta Med Iran 2017 Dec;55(12):800-806

Department of Pathology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.

A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i. Read More

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December 2017
2 Reads

Chondrosarcoma in Metachondromatosis: A Rare Case Report.

Acta Med Iran 2017 Dec;55(12):793-799

Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

Metachondromatosis which was first described in 1971 by Maroteaux is a rare genetic disease consisting of osteochondromas and enchondromas, caused by loss of function of the PTPN11 gene. It is distinct from other cartilaginous tumors such as multiple osteochondromas and hereditary multiple exostosis by the distribution and orientation of lesions, and pattern of inheritance. In Metachondromatosis osteochondromas typically occur in hands, feet, femur, and tibia while enchondromas commonly affect the pelvic bones and femurs. Read More

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December 2017
6 Reads

The Neuroprotective Effects of Flaxseed Oil Supplementation on Functional Motor Recovery in a Model of Ischemic Brain Stroke: Upregulation of BDNF and GDNF.

Acta Med Iran 2017 Dec;55(12):785-792

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Cerebral ischemic stroke is a common leading cause of disability. Flaxseed is a richest plant-based source of antioxidants. In this study, the effects of flaxseed oil (FSO) pretreatment on functional motor recovery and gene expression and protein content of neurotrophic factors in motor cortex area in rat model of brain ischemia/reperfusion (I/R) were assessed. Read More

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December 2017
8 Reads

The Effect of Rosa Damascena Extract on Expression of Neurotrophic Factors in the CA1 Neurons of Adult Rat Hippocampus Following Ischemia.

Acta Med Iran 2017 Dec;55(12):779-784

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Ischemic stroke is an important cause of death and disability in the world. Brain ischemia causes damage to brain cell, and among brain neurons, pyramidal neurons of the hippocampal CA1 region are more susceptive to ischemic injury. Recent findings suggest that neurotrophic factors protect against ischemic cell death. Read More

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December 2017
13 Reads

Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes.

Acta Med Iran 2017 Dec;55(12):772-778

Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Preterm premature rupture of membranes (PPROM) is a condition leading to an increased risk of maternal and neonatal morbidity and mortality in pregnant women. To prevent this complication, some studies have proposed using prophylactic progesterone. However, due to lack of sufficient relevant data, there is still need for further studies in this regard. Read More

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December 2017
10 Reads

The Relation of Carotid Arteries' Intima-Media Thickness With Snoring and Obstructive Sleep Apnea in Type 2 Diabetes Patients.

Acta Med Iran 2017 Dec;55(12):765-771

Department of Radiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

In recent decades, the relation of carotid artery intima-media thickness (IMT) as a marker of atherosclerosis with snoring and sleep disorders has been drawing attention. The aim of this study was to evaluate the relation of carotid arteries IMT with snoring in type 2 diabetic patients. This cross-sectional study was performed on type 2 diabetes patients referring to Mashhad University of Medical Sciences' clinics. Read More

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December 2017
8 Reads

The Association Between Bisphenol A and Polycystic Ovarian Syndrome: A Case-Control Study.

Acta Med Iran 2017 Dec;55(12):759-764

Breast Diseases Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.

Polycystic ovarian syndrome (PCOS) is an endocrine metabolic disorder with unclear etiopathogenesis among reproductive age women. Evidences show genetic susceptibility and environmental factors were associated with PCOS. The aim of this study was to find the association between urinary concentrations of Bisphenol-A as an endocrine disrupting chemical (EDC) and PCOS. Read More

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December 2017
1 Read

The Impact of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Genotypes on Sensitivity to 5-Fluorouracil Treatment in Colorectal Cancer Cells.

Acta Med Iran 2017 Dec;55(12):751-758

Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

5-fluorouracil (5-FU) is one of the major components of many standard regimens for chemotherapy of colorectal cancer (CRC) and some other malignancies. Given the known relationship between thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) activity and 5-FU metabolism, this study investigated the impact of selected functional polymorphisms of the TS and MTHFR genes on chemotherapy resistance in 5 human CRC cell lines. HCT116, SW1116, HT29/219, LS180, and Caco-2 CRC cells were cultured as monolayer and their chemosensitivity to 5-FU, oxaliplatin, and irinotecan was determined by MTT assay. Read More

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December 2017
3 Reads

The Effect of Recombinant HopH Protein of Helicobacter pylori on the VEGF Expression in Metastatic Breast Cancer Model.

Acta Med Iran 2017 Dec;55(12):744-750

Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Breast cancer imposes a considerable amount of cancer-related mortality and morbidity among women worldwide. Many efforts are in progress to reduce the disease burden and amongst the bacterial-based products received considerable attention as potential anti-cancer drugs. In the present study, the effect of recombinant pro-inflammatory outer membrane protein (HopH) of Helicobacter pylori on the angiogenic factor and tumor development in metastatic breast cancer model was evaluated. Read More

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December 2017
11 Reads

Ghrelin Alleviates MDMA-Induced Disturbance of Serum Glucose and Lipids Levels in the Rat.

Acta Med Iran 2017 Dec;55(12):736-743

Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Hepatotoxicity is one of the clinically adverse effects of ecstasy (3, 4-methylenedioxymethamphetamine; MDMA) consumption. The detoxification tissue, liver, plays a central role in maintaining circulating levels of glucose and lipid. Hypoglycemia and hypotriglyceridemia have been reported due to ecstasy abuse. Read More

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December 2017
24 Reads

Brain-Derived Neurotrophic Factor Role in Autism Remains Elusive: A Flashback on the Route That Has Brought Us Here.

Acta Med Iran 2017 Dec;55(12):733-735

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Boston, MA, USA.

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December 2017

Hiatal Hernia From Misdiagnosis to Diagnosis.

Acta Med Iran 2017 Nov;55(11):730-732

Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Complications of hiatal hernia are potentially lethal, and surgical intervention is necessary. This matter is more important in cases that have ambiguous symptoms and are diagnosed with a delay. Such patients may experience life-threatening course and events. Read More

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November 2017
5 Reads

Primary Disseminated Hydatid Cysts in a 14-Year-Old Girl: A Case Report.

Acta Med Iran 2017 Nov;55(11):726-729

Department of Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Hydatid cysts in humans usually located in the liver or lungs primarily and some case in the other organs. Sometimes, because the trauma or medical manipulating, the cyst may be rupture and protoscoleces spillage resulted in secondary hydatid cyst. Primary dissemination of cyst to multiple organs is a rare phenomenon. Read More

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November 2017
3 Reads

Isolated Right Atrial Mass in a Candidate of Coronary Bypass Grafting.

Acta Med Iran 2017 Nov;55(11):722-725

Kermanshah Cardiovascular Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Hepatocellular carcinoma (HCC) is not uncommon neoplasm, and its occurrences with coronary artery disease (CAD) is more confronted by cardiac surgeon today. In most cases, when the HCC is detected, it has invaded to regional or distant sites. The most frequent location of HCC metastasis includes pulmonary system, musculoskeletal, lymphatic system, and central nervous system. Read More

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November 2017
3 Reads

Whole Cerebral Blood Flow Originating From Vertebral Arteries After Bilateral Internal Carotid Arteries Occlusion: A Case Report.

Acta Med Iran 2017 Nov;55(11):718-721

Brain and Spinal Cord Injury Research Center (BASIR), Tehran University of Medical Sciences, Tehran, Iran.

Bilateral occlusion of internal carotid arteries is a rare condition usually associated with severe neurological symptoms. It is very uncommon finding among patients with ischemic stroke. In this article, we report a rare case of bilateral occlusion of internal carotid artery who presented with mild reversible neurological symptoms. Read More

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November 2017
7 Reads

The Prevalence of Allergic Rhinitis and It's Relationship With Second-Hand Tobacco Smoke Among Adults in Iran.

Acta Med Iran 2017 Nov;55(11):712-717

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

To determine the prevalence of allergic rhinitis (AR) among adult residents and investigate whether second-hand tobacco smoke (SHS) is correlated with AR as one of the global health problems and one of the most common respiratory disorders reducing the quality of life. A telephone interview survey was conducted by calling 16500 randomly selected telephone numbers from 22 regional telecommunications of Tehran (capital city of Iran) in 2010. A modified European Community Respiratory Health Survey (ECRHS) questionnaire was completed for adults aged between 20 to 44-year-old. Read More

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November 2017
6 Reads

Evaluation of Patients Visiting the Dermatology Emergency Unit of a University Dermatology Hospital in Tehran, Iran.

Acta Med Iran 2017 Nov;55(11):705-711

Department of Dermatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Published studies on dermatological emergencies are limited in the literature. To our knowledge, no study has previously explored this subject in Iran. Our aim was to ascertain the characteristics of patients visiting the dermatologic emergency (DE) unit of a university skin hospital in Tehran, Iran. Read More

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November 2017
4 Reads

Calculation of Mitral Valve Area in Mitral Stenosis: Comparison of Continuity Equation and Pressure Half Time With Two-Dimensional Planimetry in Patients With and Without Associated Aortic or Mitral Regurgitation or Atrial Fibrillation.

Acta Med Iran 2017 Nov;55(11):696-704

Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Accurate measurement of Mitral Valve Area (MVA) is essential to determining the Mitral Stenosis (MS) severity and to achieving the best management strategies for this disease. The goal of the present study is to compare mitral valve area (MVA) measurement by Continuity Equation (CE) and Pressure Half-Time (PHT) methods with that of 2D-Planimetry (PL) in patients with moderate to severe mitral stenosis (MS). This comparison also was performed in subgroups of patients with significant Aortic Insufficiency (AI), Mitral Regurgitation (MR) and Atrial Fibrillation (AF). Read More

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November 2017
11 Reads

Relationship Between Sleep Quality, Obstructive Sleep Apnea and Sleepiness During Day With Related Factors in Professional Drivers.

Acta Med Iran 2017 Nov;55(11):690-695

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

One of the important reasons for accidents is sleepiness.With this description, the sleep disorders are associated with health and mortality, and not only affect the person but also the family and the whole society. Aim of this study was assessing of relationship between Sleep Quality, Obstructive sleep Apnea and Sleepiness during day with related factors in professional drivers. Read More

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November 2017
11 Reads

The Effect of Vestibular Rehabilitation Therapy Program on Sensory Organization of Deaf Children With Bilateral Vestibular Dysfunction.

Acta Med Iran 2017 Nov;55(11):683-689

Department of Occupational Therapy, University of Social Welfare and Rehabilitation, Tehran, Iran.

The purpose of this study was to determine the effect of vestibular rehabilitation therapy program on the sensory organization of deaf children with bilateral vestibular dysfunction. This cross-sectional and analytic study was conducted on 24 students between the age of 7 and 12 years (6 girls and 18 boys) with the profound sensorineural hearing loss (PTA>90 dB). They were assessed through the balance subtest in Bruininks-Oseretsky test of motor proficiency (BOTMP). Read More

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November 2017
4 Reads

PDCD1 Single Nucleotide Polymorphisms in Iranian Patients With Juvenile Idiopathic Arthritis.

Acta Med Iran 2017 Nov;55(11):676-682

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Juvenile idiopathic arthritis (JIA) is a clinically heterogeneous cluster of complex diseases, in which both the genetic and environmental factors seem to play a role in the development of the disease. The current study aims to assess the association of programmed cell death 1 (PDCD1, also called PD-1) gene variants with JIA vulnerability in Iranian population. In this case-control association study, we investigated a group of 50 Iranian patients with JIA in comparison with 202 healthy controls and evaluated the frequency of alleles, genotypes, and haplotypes of PDCD1 single-nucleotide polymorphisms (SNPs), comprising PD-1. Read More

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November 2017
5 Reads

Association of Transforming Growth Factor-Beta Gene Polymorphisms in Recurrent Aphthous Stomatitis.

Acta Med Iran 2017 Nov;55(11):672-675

Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

This study has been conducted to evaluate the allele, genotype and haplotype frequencies of the polymorphic gene coding TGF-β in recurrent aphthous stomatitis (RAS). TGF-β gene typing was done by polymerase chain reaction with sequence-specific primers (PCR-SSP) assay. Allele frequencies were estimated by direct gene counting. Read More

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November 2017
3 Reads

Association Between IL6-174 G/C Polymorphism and Graves' Disease: A Systematic Review and Meta-Analysis.

Acta Med Iran 2017 Nov;55(11):665-671

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Rheumatology Expert Group (REG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Several studies have evaluated the association between interleukin-6 (IL-6) -174 G/C polymorphism and Graves' disease (GD); however, the results have been inconsistent. In the current study, a meta-analysis was performed to assess the association of IL6 -174 G/C polymorphism with Graves' disease. Medline, EMBASE, and Web of Science databases were searched to identify all eligible studies published before August 2016. Read More

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November 2017
4 Reads

The Role of PIEZO2 in Human Mechanosensation.

Acta Med Iran 2017 Oct;55(10):664

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Systematic Review and Meta-Analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

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October 2017
2 Reads

A Case With Short Stature, Growth Hormone Deficiency and 46, XX, Xq27-qter Deletion.

Acta Med Iran 2017 Oct;55(10):661-663

Department of Medical Genetics, School of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.

We report a case of 11-year-old girl with growth retardation and 46, XX, Xq27-qter deletion. The endocrinologic evaluation revealed growth hormone deficiency. In karyotype analysis  46, XX, Xq27-qter deletion was determined. Read More

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October 2017
7 Reads

Denosumab Treatment of Severe Disuse Osteoporosis in a Boy With Spinal Muscular Atrophy.

Authors:
Stepan Kutilek

Acta Med Iran 2017 Oct;55(10):658-660

Department of Pediatrics, Pardubice Hospital, Pardubice, Czech Republic.

Denosumab is a fully human recombinant monoclonal antibody to the receptor activator of nuclear factor-κB ligand. Denosumab is used in the treatment of postmenopausal osteoporosis and cancer-related bone disorders. There are only very scarce data on denosumab treatment in children. Read More

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October 2017
7 Reads

Pericentric Inversion of Chromosome 9 in an Infant With Ambiguous Genitalia.

Acta Med Iran 2017 Oct;55(10):655-657

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Pericentric inversion of Chromosome 9 is one of the most common chromosomal abnormalities, which could be associated with various manifestations in some cases. Herein, a patient is presented with ambiguous genitalia that karyotyping revealed pericentric inversion of Chromosome 9 (p12,q13). Pericentric inversion of Chromosome 9 could be considered in the list of differential diagnosis of those with ambiguous genitalia, while chromosomal karyotype and culture could be recommended in children with ambiguous genitalia. Read More

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October 2017
11 Reads

Kleefstra Syndrome: The First Case Report From Iran.

Acta Med Iran 2017 Oct;55(10):650-654

Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Kleefstra Syndrome is characterized by severe mental retardation, brachycephaly, microcephaly, epileptic seizures, distinct facial features, and infantile weak muscle tone and heart defects. Deletion of EHMT1 is the main player in 75% of cases. Because of blurriness in genotype-phenotype correlation through clinical and molecular features of both 9q34. Read More

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October 2017
5 Reads

Electronic Health Record Implementation: A SWOT Analysis.

Acta Med Iran 2017 Oct;55(10):642-649

Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Electronic Health Record (EHR) is one of the most important achievements of information technology in healthcare domain, and if deployed effectively, it can yield predominant results. The aim of this study was a SWOT (strengths, weaknesses, opportunities, and threats) analysis in electronic health record implementation. This is a descriptive, analytical study conducted with the participation of a 90-member work force from Hospitals affiliated to Tehran University of Medical Sciences (TUMS). Read More

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October 2017
3 Reads

Efficacy of Bronchial Washing and Brushing Cytology in the Diagnosis of Non-Neoplastic Lung Diseases.

Acta Med Iran 2017 Oct;55(10):636-641

Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Flexible fiberoptic bronchoscopy is often the initial technique for diagnosis of lung and bronchial tumors. Many studies have shown the high accuracy rate of bronchial washing and brushing cytology in the evaluation of neoplastic and non-neoplastic bronchopulmonary lesions. The aim of this study is to emphasize the value of the bronchial cytologic findings for diagnosis of non-neoplastic bronchopulmonary lesions. Read More

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October 2017
10 Reads

The Dilemma of Irrational Antibiotic and Corticosteroid Prescription in Iran: How Much It Can Affect the Medicine Expenditures?

Acta Med Iran 2017 Oct;55(10):628-635

Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.

In recent years the high cost of medicines and the lack of it were one of the major problems in developing countries that despite numerous efforts to solve the root causes of this problem, the issue remains, unfortunately. Therefore, this study aimed to assess the impact of antibiotics and corticosteroids prescription on the medicines expenditures. This was descriptive-analytical study that conducted to assess the function of medical expenditures through prescription letters and analysis the factors affecting medicine expenditures. Read More

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October 2017
6 Reads

Synergistic Effects of Resistin and Visfatin as Adipocyte Derived Hormones on Telomerase Gene Expression in AGS Gastric Cancer Cell Line.

Acta Med Iran 2017 Oct;55(10):621-627

Cellular and Molecular Endocrine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Department of Clinical Biochemistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Recently suggested that adipocytokines may play a role in pathogenesis and progression of certain cancers, especially in gastric cancer. The previous study showed Resistin and Visfatin, as adipocyte derived hormones, separately increases telomerase (hTERT) gene, the aim of this study is investigating synergic effects of Resistin and Visfatin on telomerase gene expression, in AGS gastric cancer cell line. In this study, human gastric cancer AGS cell line was selected. Read More

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October 2017
8 Reads

Study of Serum Malondialdehyde Level in Opioid and Methamphetamine Dependent Patients.

Acta Med Iran 2017 Oct;55(10):616-620

Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Kermanshah, Iran.

Opioid compound and methamphetamine are commonly used in drug abuse; these can disrupt the normal function of cellular and molecular systems, leading to several events such as oxidative stress, aging, apoptosis, and necrosis. Malondialdehyde (MDA) is the most important biomarker for evaluation of oxidative stress and determination of lipid peroxidation. In this study, 42 drug abusers and 22 healthy persons participated as case and control groups, respectively. Read More

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October 2017
14 Reads

Sleep Apnea and Idiopathic Leg Edema: A Case Control Study.

Acta Med Iran 2017 Oct;55(10):612-615

Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Amir A'alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Idiopathic leg edema is subject to a lot of debates among physicians. Recently sleep apnea was stated to be the cause. We sought to investigate this matter in a sample of Iranian patients with idiopathic leg edema. Read More

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October 2017
6 Reads

Evaluation of Antibody and Cytokines Responses in Intranasally and Intramuscularly Administrated BALB/C Mice With Influenza Virus-Like Particle.

Acta Med Iran 2017 Oct;55(10):604-611

Department of Virology, School of Public Health, National Influenza Center, Tehran University of Medical Sciences, Tehran, Iran.

We previously developed an influenza virus like particle with HA, M, and NA proteins using Bac-to-Bac expression system and SF9 cell line. To evaluate the immunogenicity of our construct, we assessed the humoral, cytokine induced by H1N1-VLP in BALB/c mice immunized intranasally and intramuscularly. Enzyme-linked immunosorbent assay and Relative quantitative real-time PCR were used to evaluate the antibody (IgG and IgA) and mRNA levels of IL-6, IL-4, IL-10 and IFN-g in PBMCs. Read More

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October 2017
10 Reads

A Rare Reason of Abnormal Uterine Bleeding.

Acta Med Iran 2017 Sep;55(9):602-603

Department of Obstetrics and Gynecology, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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September 2017
5 Reads

Drug-Induced by Systemic Lupus Erythematosus Presenting as Recurrent Pericardial Effusion After Mitral Valve Repair.

Acta Med Iran 2017 Sep;55(9):597-601

Department of Cardiac Surgery, Imam Ali Hospital, Kermanshah University of Medicine, Kermanshah, Iran.

We report a patient presented with recurrent pericardial effusion caused by drug-induced systemic lupus Erythematosus (SLE) following mitral valve repair. The surgery was complicated by hemiparesis and convulsion in early postoperative period. The patient had been received carbamazepine for a paroxysmal seizure that occurred following mitral valve repair. Read More

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September 2017
6 Reads