862 results match your criteria Acta medica Indonesiana[Journal]


Diagnosis and Management of Heatstroke.

Acta Med Indones 2020 Jan;52(1):90-97

Department of Internal Medicine, Faculty of Medicine, University of Mataram - West Nusa Tenggara General Hospital.

Heatstroke is a life-threatening  and the most severe form of heat-related illnesses, characterized by body temperature >40ºC and central nervous system dysfunction. Heatstroke is classified into Non-Exertional Heatstroke (NEHS) and Exertional Heatstroke (EHS). The pathophysiology of heatstroke involves a combination of direct heat effects on the host, the systemic inflammatory and coagulopathic response. Read More

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January 2020

COVID-19 and Indonesia.

Acta Med Indones 2020 Jan;52(1):84-89

Department of Internal Medicine - Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo Hospital - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Coronavirus disease 2019 (COVID-19) pandemic is an ongoing problem in more than 200 countries in the world. Indonesia has been greatly affected by COVID-19 with case fatality rate (CFR) being 8.9% in the end of March 2020. Read More

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January 2020

Clinical Progression of COVID-19 Patient with Extended Incubation Period, Delayed RT-PCR Time-to-positivity, and Potential Role of Chest CT-scan.

Acta Med Indones 2020 Jan;52(1):80-83

Department of Pulmonology, Faculty of Medicine Universitas Indonesia - Persahabatan Hospital, Jakarta, Indonesia.

Coronavirus Disease 2019 (COVID-19), previously called 2019-nCoV, is a novel disease caused by SARS- CoV-2 which was first identified as outbreak of unknown respiratory illness in Wuhan, China. COVID- 19 was declared as global health emergency by WHO on March 11, 2020 and quickly elevated to global pandemic on 11 March 2020. COVID-19 symptom is highly various in each patient, with fever, fatigue, shortness of breath, and cough as the main presenting symptoms. Read More

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January 2020

Hyperkalemia Associated with Angiotensin Converting Enzyme Inhibitor or Angiotensin Receptor Blockers in Chronic Kidney Disease.

Acta Med Indones 2020 Jan;52(1):74-79

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.

Inhibition of the renin-angiotensin-aldosterone system (RAAS) is a key strategy in treating hypertension in cardiovascular and renal diseases. However, RAAS inhibitors (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosterone receptor antagonists, and direct renin inhibitors) increase the risk of hyperkalemia (serum potassium >5.5 mmol/L). Read More

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January 2020

The Importance of Chest CT Scan in COVID-19.

Acta Med Indones 2020 Jan;52(1):68-73

Division of Respirology and Critical Care, Departement of Internal Medicine, Faculty of Medicine Universitas Indonesia. Dr Cipto Mangunkusumo National General Hospital. Imperial College London.

The coronavirus disease 2019 (COVID-19) is a highly transmissible acute respiratory disease that is caused by the Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2), a beta coronavirus first discovered in Wuhan, China, in late 2019. COVID-19 has been spreading swiftly globally, and as of March 2020, has been officially declared a pandemic by the World Health Organization (WHO). One of the challenges in managing COVID-19 is the identification of a swift, accessible, and reliable diagnostic modality that could serve as an alternative to a reverse-transcriptase polymerase chain reaction (RT-PCR). Read More

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January 2020

Gastrointestinal Presentation in COVID-19 in Indonesia: A Case Report.

Acta Med Indones 2020 Jan;52(1):63-67

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently causing a widespread infection in the world. During the pandemic, physicians may need to raise the index of suspicion earlier in at-risk patients presenting with gastrointestinal symptoms, which are uncommon findings in coronavirus disease 2019 (COVID-19) patients. We report a patient in Indonesia with chest pain and gastrointestinal symptoms who was later confirmed to have SARS-CoV-2 infection after spending days of hospitalisation in the standard ward. Read More

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January 2020

Pregnancy Profile and Infant Outcomes Among HIV Infected Women Who Delivered in Cipto Mangunkusumo Hospital.

Acta Med Indones 2020 Jan;52(1):55-62

Departement of Obstetric and Gynecology Universitas Indonesia.

Background: HIV infection in pregnancy is a big concern for the future of our nation. The virus can be transmitted to the baby through pregnancy, childbirth and during breastfeeding which rendering to early detection and intervention. The aim of this study was to describe the transmission prevention cascade among our patient. Read More

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January 2020

Global Longitudinal Strain (GLS) in Elderly and Its Associated Factors.

Acta Med Indones 2020 Jan;52(1):47-54

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: cardiovascular disease is very common and can be fatal in elderly patients. It is often preceded by asymptomatic or subclinical left ventricular systolic dysfunction (LVSD). Early detection of LVSD can reduce morbidity and mortality due to cardiovascular disease. Read More

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January 2020

Three Years Survival of Elderly Cancer Patients in Indonesia: Do We Need a Different Approach?

Acta Med Indones 2020 Jan;52(1):39-46

Division of Hematology and Medical Oncology, Dept. of Internal Medicine, Dharmais Cancer Hospital, Jakarta, Indonesia.

Background: the number of elderly people in Indonesia is increasing. Additionally, cancer prevalence among older patients is also increasing. However, studies assessing clinical factors associated with the survival of elderly patients with cancer are still lacking. Read More

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January 2020

Six-month Survival of Patients with Malignant Distal Biliary Stricture Following Endoscopic Biliary Stent Procedure and Its Associated Factors.

Acta Med Indones 2020 Jan;52(1):31-38

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: unresectable malignant distal biliary stricture patients require endoscopic biliary stent placement procedure. The survival rate and its associated factors in Indonesia are unknown.

Objectives: To identify 6-month survival of patients with malignant distal biliary stricture following endoscopic biliary stent procedure and its associated factors. Read More

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January 2020

Comparative Effectiveness of Tuberculosis Treatment Daily versus Intermittent Regimen in Indonesian TB-DM Patients: Real World Patient Database Study.

Acta Med Indones 2020 Jan;52(1):25-30

Clinical Pharmacology Specialist Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: diabetes mellitus (DM) increases the risk of active TB by three times; there is no specific treatment strategy for tuberculosis-DM (TB-DM) patients. The 2017 WHO guidelines no longer recommended an intermittent regimen in the advanced phase of TB treatment due to higher risk of failure, relapse, and drug resistance compared to the daily regimen. This study aims to compare the effectiveness of treatment, in terms of clinical response and sputum conversion, of TB-DM patients in the advanced phase between the two-treatment delivery schedules. Read More

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January 2020

IDENTIA Registry: Incidence of Deep Vein Thrombosis in Medically Ill Subjects at High Risk in Indonesia: A Prospective Study.

Acta Med Indones 2020 Jan;52(1):14-24

Department of Internal Medicine, Cikini Hospital and Universitas Indonesia, Jakarta, Indonesia.

Background: medically ill hospitalized patients are at risk of deep vein thrombosis (DVT) and consequentially have high chances of mortality. In Indonesia, there is disparity in healthcare facility and data on incidence of DVT in this multi-ethnic, geographically unique country with large population are limited. Hence, we determined the incidence of DVT and evaluated mean Wells score among medically ill hospitalized persons at increased risk. Read More

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January 2020

Sarcopenia and Frailty Profile in the Elderly Community of Surabaya: A Descriptive Study.

Acta Med Indones 2020 Jan;52(1):5-13

Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia.

Background: sarcopenia and frailty cause immobility, disability, neuromuscular disorders, and homeostatic balance failure syndrome, characterized by gait and balance abnormalities in the elderly, and an increasing prevalence worldwide. This further contributes to the elevated incidence of falls and fractures, hospitalization, immobilization, and even mortality, hence, a national-level study was conducted on the prevalence rates of sarcopenia and frailty in the elderly.

Methods: this descriptive study used primary data of elderly people (n = 308) in Surabaya, Indonesia. Read More

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January 2020

Diagnosing COVID-19: Did We Miss Anything?

Acta Med Indones 2020 Jan;52(1):1-4

Division of Respirology and Critical Care, Departement of Internal Medicine, Universitas Indonesia. Dr. Cipto Mangunkusumo National General Hospital. Imperial College London.

In late 2019, a mass of patients showing symptoms of a pneumonia-like disease of unknown origin emerged in Wuhan, China. Little did the world know it was the prelude of what would be a devastating pandemic. Samples were collected from these patients and the use of unbiased sequencing, and subsequent isolation of the pathogen using human airway epithelial cells led to the discovery of a novel coronavirus, named 2019-nCoV by the World Health Organization (WHO) and Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses. Read More

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January 2020

Practical Guidelines Management of Graves Ophthalmopathy.

Acta Med Indones 2019 Oct;51(4):364-371

Division of Endocrinology and Metabolism, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta.

Graves' ophthalmopathy is the most common extra-thyroid manifestation in patients with Graves' disease, based on inflammatory and autoimmune conditions in orbital tissue. This practical guideline was formed by a multidiciplinary team, and is intended to provide guidance for diagnosis and management of Graves' ophthalmopathy in daily clinical practice to improve quality of care and treatment outcome. Read More

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October 2019

Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report.

Acta Med Indones 2019 Oct;51(4):356-363

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: liver cancer is currently the second deadliest cancer in the world with hepatocelullar carcinoma (HCC) being the commonest form-accounting 90% of all its cases. With the current global alarming increase of obesity, there is hence an increase of fatty liver disease cases, which is one of the major non-viral etiology of cirrhosis in the world. The objective of this study is to evaluate whether obese HCC patients have worse survival outcome. Read More

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October 2019

Renal Tuberculosis: The Masquerader.

Acta Med Indones 2019 Oct;51(4):353-355

Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran Hasan Sadikin General Hospital, Bandung, Indonesia.

Tuberculosis (TB) remains a worldwide scourge and the most common cause of mortality from infectious disease. Around 95% of cases occur in developing country. Renal TB is a rare cases that complicates 3-4% of pulmonary TB patients and commonly overlooked in clinical practice due to its symptoms may mimic other diseases. Read More

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October 2019

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.

Acta Med Indones 2019 Oct;51(4):348-352

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Chronic myeloid leukemia (CML) is a clonal haemopoietic stem cell disorders with reciprocal translocation in chromosome 9 (ch9) and 22 (ch22) which cause the fusion of Break cluster region-Abelson murine leukemia (BCR-ABL) oncogene. This fusion will activate tyrosine kinase. Imatinib mesylate is the first tyrosine kinase inhibitor (TKI), which could change the prognosis of CML patients. Read More

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October 2019

A Case Report on Cholestatic Jaundice Secondary to Adverse Effect of Phaleria macrocarpa (Mahkota Dewa).

Acta Med Indones 2019 Oct;51(4):344-347

Department of Internal Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.

Drug induced cholestatic liver injury can posed a great diagnostic difficulty as a result of its long non-exhaustive list of potential offending causes which can be either prescribed or over-the-counter medications, such as medicinal herbs and remedies. Phaleria macrocarpa, or more commonly known as the 'God's crown' by the local people of South East Asia, is not listed as one of the causes. This medicinal plant extract has been increasingly used for traditional treatment for various ailments. Read More

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October 2019

"Fleshy" Skin Cellulitis: A Triggering Factor for ANCA Associated Vasculitis.

Acta Med Indones 2019 Oct;51(4):338-343

Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC).

A 59-year-old lady with underlying hypothyroidism presented with acute contact dermatitis progressed to cellulitis with superimposed bacterial infection and acute kidney injury. She responded to initial management with antibiotics, but a week later, she had cutaneous and systemic vasculitis. Her skin biopsy consistent with immune-mediated leuko-cytoclastic vasculitis and her blood test was positive for cytoplasmic-anti-neutrophil cytoplasmic antibody (c-ANCA). Read More

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October 2019

Intact Glycocalyx of Intestinal Mucosa in Intraabdominal Infection: an Investigation Using Blood Group Antigen.

Acta Med Indones 2019 Oct;51(4):331-337

Department of Surgery, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: intestinal glycocalyx plays a role in bacterial translocation as the pathogenesis sepsis derived from intra-abdominal infections that vulnerable in certain blood types. However, the link between intestinal glycocalyx in specific types of blood groups and abdominal infections remains unknown. This study aims to find out the condition of intestinal glycocalyx in certain blood types with intraabdominal sepsis. Read More

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October 2019

Factors Associated with Mortality of Intensive Care Unit Patients with Acute Kidney Injury at Cipto Mangunkusumo National Central General Hospital.

Acta Med Indones 2019 Oct;51(4):324-330

Division of Renal and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: the incidence of acute kidney injury (AKI) in intensive care units is associated with increased mortality, post AKI morbidity and high treatment costs. Research on factors related to mortality of AKI patients in intensive care units in Indonesia, especially Cipto Mangungkusumo General Hospital has never been done. This study aims to determine the prevalence of AKI, mortality rate of AKI patients, and the factors associated with increased mortality of AKI patients in intensive care units in ICU Cipto Mangunkusumo General Hospital. Read More

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October 2019

Validity and Reliability of the Indonesian Version of Kidney Disease Quality of Life (KDQOL-36) Questionnaire in Hemodialysis Patients at Hasan Sadikin Hospital, Bandung, Indonesia.

Acta Med Indones 2019 Oct;51(4):318-323

Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia.

Background: the prevalence of chronic kidney disease (CKD) and dialysis patients is increasing every year in Indonesia. The impact of CKD and dialysis on patient quality of life (QOL) has been recognized as an important outcome measure in the management of CKD. The Kidney Disease Quality of Life (KDQOL-36) has been validated and is widely used as a measure of QOL for CKD and dialysis patients in many countries, but not in Indonesia. Read More

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October 2019

Effect of Oral N-Acetylcysteine Supplementation on the Immunity System in Patients with Acute Myocardial Infarction.

Acta Med Indones 2019 Oct;51(4):311-317

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University - Dr. Moewardi Hospital, Surakarta, Indonesia.

Background: inflammation, oxidative stress, and fibrosis play important roles after an acute myocardial infarction (AMI) event. The most studied inflammatory biomarker in cardiovascular disease is C-reactive protein (CRP). It has been demonstrated that myeloperoxidase (MPO) and Galectin-3 (Gal-3) have some essential roles on immune system when an AMI event occurs. Read More

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October 2019

A Double-blind, Randomized Controlled Trial of Ciplukan (Physalis angulata Linn) Extract on Skin Fibrosis, Inflammatory, Immunology, and Fibrosis Biomarkers in Scleroderma Patients.

Acta Med Indones 2019 Oct;51(4):303-310

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University - Hasan Sadikin Hospital, Bandung, Indonesia.

Background: scleroderma is an autoimmune disease characterized by organ fibrosis, resistant to standard treatment. It is suspected the addition of Physalis angulata Linn. (Ciplukan) extract as adjuvant therapy can improve the scleroderma skin fibrosis. Read More

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October 2019

Factors Associated with Pain in Palliative Patients and the Role of Spiritual Services in Pain Management.

Acta Med Indones 2019 Oct;51(4):296-302

Division of Psychosomatic and Palliative Care. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: pain is one of the most often symptoms experienced by patients with advanced or chronic diseases which can cause a decrease in the quality of life of palliative patients. Pain in palliative patients has not yet received enough attention, especially factors associated with pain and its management. This study aimed to determine the factors associated with pain in palliative patients and also assess whether there is a two-way relationship between psychological factors and pain. Read More

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October 2019

Plasma Concentrations of Adiponectin in Patients with Coronary Artery Disease and Coronary Slow Flow.

Acta Med Indones 2019 Oct;51(4):290-295

Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Background: Adiponectin, an adipocyte-secreted hormone involved in energy homeostasis, has broad anti-inflammatory, antioxidant, and endothelium- and myocardial-protective effects, together with a potentially positive regulatory function in coronary microcirculation. Although the physiological role of adiponectin has not yet been fully elucidated, it may well be involved in the regulation of many of the inflammatory processes or lipid metabolisms that contribute to atherosclerosis. In this study we investigate the plasma concentration of adiponectin in patients with coronary artery disease (CAD), those with coronary slow flow (CSF) and in healthy subjects. Read More

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October 2019

Targeting Inflammation and Immune System in Acute Myocardial Infarction.

Authors:
Idrus Alwi

Acta Med Indones 2019 Oct;51(4):287-289

Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Over more than two decades, the concept of atherosclerosis has developed and lead to inflammatory hypothesis. Inflammation plays an important role on pathogenesis of atherothrombosis and coronary heart disease (CHD), including acute coronary syndrome (ACS). Although the management of ACS has been demonstrated to be beneficial for secondary prevention of coronary heart disease (such as using statin and aspirin) and also seemed to have positive effect on inflammation, the identification of effective management, specifically targeting inflammation, has been not been comprehensively understood. Read More

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October 2019

Aspirin vs. P2Y12 Inhibitor Rivalry: Which One Can be Continued During Gastrointestinal Bleeding.

Acta Med Indones 2019 Jul;51(3):282-286

Division of Gastroenterohepatology Department of Internal Medicine Faculty of Medicine - University of Padjadjaran Hasan Sadikin General Hospital Bandung - Indonesia.

Dual antiplatelet therapy (DAPT) is the mainstay of secondary prevention treatment for acute coronary syndrome (ACS) and ischemic stroke, especially after coronary intervention. DAPT consists of aspirin and P2Y12 receptor inhibitor (e.g. Read More

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Tadalafil Once a Day for Men with Erectile Dysfunction: Is It Superior than On-Demand Administration?

Acta Med Indones 2019 Jul;51(3):275-281

Department of Urology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Tadalafil is a PDE5I which has been licensed for the treatment of erectile dysfunction (ED) since 2003, is effective from 30 minutes after administration and its efficacy is maintained for up to 36 hours. More recently, it is also given OAD in a lower dose to allow spontaneous sexual activities. However, whether OAD administration is more effective than PRN administration in improving the EF is yet to be established. Read More

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Late Diagnosis of Congenital Hypothyroidism in Young Adult.

Acta Med Indones 2019 Jul;51(3):272-274

Department of Internal Medicine, Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Atma Jaya University Hospital, Jakarta, Indonesia.

Congenital hypothyroidism is the most treatable cause of mental retardation. It is also the most prevalent congenital endocrine disorder in childhood. A dramatic improvement can be made by early detection, diagnosis, and adequate treatment of levothyroxine in patients with congenital hypothyroidism. Read More

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July 2019
3 Reads

Diabetic Gastroenteropathy: A Complication of Diabetes Mellitus.

Acta Med Indones 2019 Jul;51(3):263-271

Faculty of Medicine, Airlangga University, Surabaya-Indonesia; Dr Soetomo General Hospital, Surabaya-Indonesia.

Diabetic gastroenteropathy is a common complication in prolonged diabetic patients, particularly patients with poor glycemic control or other complications, including all form of diabetic complication on the gastrointestinal tract, which prompts various symptoms of heartburn, abdominal pain, nausea, vomiting, even constipation, diarrhea, and fecal incontinence. The underlying pathophysiology of this complication manifestations are different on each organ or symptom, but may include autonomic nervous system neuropathy, loss of Interstitial Cell of Cajal as gastric muscle pacemaker leading to dysmotility, impair of liquid transportation and motoric function, as well as hyperglycemia causing oxidative stress, and other factors like Insulin-Growth Factor I inducing smooth muscle atrophy. Diabetic gastroenteropathy is one of major morbidity on diabetes mellitus patients. Read More

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Acquired Hemophilia A Associated with NSAID: A Case Report.

Acta Med Indones 2019 Jul;51(3):258-262

Department of Clinical Pathology, Faculty of Medicine Universitas Airlangga - Dr. Soetomo Teaching Hospital, Surabaya, Indonesia..

Acquired hemophilia A (AHA) is a blood clotting disorder caused by the presence of autoantibodies (inhibitors) against factor VIII. The typical symptom of this disorder is bleeding under the skin and soft tissue (rarely in the joints), with no family or personal previous history of bleeding. This case reports is tended to build up awareness for better diagnosis and therapy. Read More

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July 2019
5 Reads

HIV Drug Resistance after Failure of 6 Month First-line Therapy in a Hospital: A Case Series.

Acta Med Indones 2019 Jul;51(3):253-257

Department of Microbiology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

This is the first report of HIV drug resistance in RSUPN Dr. Cipto Mangunkusumo. We tested We reviewed eleven new cases of HIV patients who had virologic failure after 6 months first-line antiretroviral therapy. Read More

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The Role of Serum Expression Levels of Microrna-21 on Bone Mineral Density in Hypostrogenic Postmenopausal Women with Osteoporosis: Study on Level of RANKL, OPG, TGFβ-1, Sclerostin, RANKL/OPG Ratio, and Physical Activity.

Acta Med Indones 2019 Jul;51(3):245-252

Departement of Internal Medicine, Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan.

Background: MiR-21 is known to play a role in osteoclast proliferation and differentiation, but the role of serum miR-21 expression in osteoporosis remains unclear. Previous research found that serum miR-21 expression was positively correlated with bone mineral density in postmenopausal osteoporosis patients, but other factors involved in postmenopausal osteoporosis still unknown. This study aimed to determine the role of serum miR-21 expression, concentration of RANKL, OPG, TGF-β1, sclerostin and serum calcium, RANKL/OPG ratio, and physical activity on bone mineral density of spine in hypoestrogenic postmenopausal women with osteoporosis (PMOP) compared with no osteoporosis (PMNOP), with point of interest on the expression of serum miR-21. Read More

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Predictors of 30-day Mortality in ST-Elevation Myocardial Infarction (STEMI) Patients.

Acta Med Indones 2019 Jul;51(3):238-244

Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital.

Background: to identify other factors other than the TIMI scores that can be used as predictors of 30-day mortality in STEMI patients by including variables of left ventricle ejection fraction (LVEF) and glomerulus filtration rate (GFR) at Cipto Mangunkusumo National Central General Hospital.

Methods: a retrospective cohort study was conducted in 487 STEMI patients who were hospitalized at RSUPN Cipto Mangunkusumo between 2004 and 2013. Sample size was calculated using the rule of thumbs formula. Read More

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Clinical Comparison of Renogen, a Biosimilar Epoetin-a, with the Originator, Eprex, in Chronic Kidney Disease Anemia in Indonesia: A Preliminary Study.

Acta Med Indones 2019 Jul;51(3):230-237

Universitas Indonesia.

Background: treatment of erythropoietin (EPO) is essential in chronic kidney disease (CKD) patients to maintain optimal hemoglobin (Hb) level. Renogen is a biosimilar epoetin-α, and Eprex is the originator epoetin-α. This study aimed to compare the efficacy and tolerance of Renogen with Eprex in CKD anemia. Read More

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Factors Associated with Physical Frailty in Elderly Women with Low Socioeconomic Status in Urban Communities: A Cross-Sectional Study.

Acta Med Indones 2019 Jul;51(3):220-229

Department of Internal Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Background: there are differences in factors associated with frailty syndrome in elderly population. The aim of this research was to determine frailty status (fit, pre-frail and frail) and to identify factors associated with physical frailty in urban community-dwelling elderly women.

Methods: a cross-sectional study of community-dwelling women aged 60 years and older was conducted in West and Central Jakarta regions, Indonesia, from July until September 2017. Read More

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Low Body Mass Index as a Risk Factor for Antiretroviral Drug-Related Liver Injury Among HIV Patients.

Acta Med Indones 2019 Jul;51(3):214-219

Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran.

Background: antiretroviral drug-related liver injury (ARLI) is a drug-induced hepatotoxicity due to antiretroviral medication (ARV). It commonly disrupts compliance to treatment and causes treatment discontinuation in HIV-infected patients. Several studies have been conducted on predisposing factors for ARLI including studies on body mass index (BMI) and cluster of differentiation 4 (CD4). Read More

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Diphtheria Epidemiology in Indonesia during 2010-2017.

Acta Med Indones 2019 Jul;51(3):205-213

Department of Child Health Faculty of Medicine University of Indonesia Jakarta.

Background: in recent years, diphtheria has reemerged in several countries including Venezuela, Yemen, Bangladesh, and Haiti. Similarly, Indonesia also showed an increased number of diphtheria cases in 2010-2017 despite the Diphteria, Tetanus, Pertussis (DTP) immunization program applied in Indonesia for children. This study aimed to evaluate the epidemiology of diphtheria cases which occurred in Indonesia during 2010-2017. Read More

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The Emergence of HIV-1 Transmitted Drug Resistance Mutations Among Antiretroviral Therapy-naive Individuals in Buleleng, Bali, Indonesia.

Acta Med Indones 2019 Jul;51(3):197-204

Universitas Airlangga.

Background: the global scale-up of antiretroviral therapy (ART) is the primary factor contributing to the decline in deaths from acquired immune deficiency syndrome (AIDS)-related illnesses. However, the emergence of transmitted drug resistance (TDR) compromises the effects of ART in treatment-naïve individuals, which may hinder treatment success. The present study aimed to identify the presence of TDR among treatment-naive individuals in Buleleng, Bali, which is currently ranked sixth among Indonesian provinces with the highest cumulative human immunodeficiency virus type 1 (HIV-1) infection cases. Read More

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The Threat of Emerging and Re-emerging Infections in Indonesia.

Acta Med Indones 2019 Jul;51(3):195-196

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Human immunodeficiency virus (HIV) is one example of an emerging infection with total of 386 district of all province in Indonesia reported having such infection; with cumulative number of HIV infected patient from the year 1987 to 2014 is 150,296 while AIDS is 55,799 patients. The access to care only available for 153,887 patients among all HIV/AIDS patients of whom 70% are eligible for anti-retroviral (ARV) treatment and of these only half adhered to ARV treatment. In addition to that, there is an increased risk of other emerging diseases such as Zika virus, Monkey pox or Hanta pulmonary syndrome since a sporadic cases were reported around the region. Read More

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Diagnostic Approach for Thyroid Nodules.

Acta Med Indones 2019 Apr;51(2):189-193

Department of Internal Medicine, Cipto Mangunkusumo Hospital - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Thyroid nodule is a health problem which commonly found in daily practice, therefore clinical guidance is needed. This guideline was compiled by a multidisciplinary team and expected to be a guideline in diagnosing thyroid nodules on daily clinical practice. Read More

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April 2019
3 Reads

The Risk of Developing Non-Alcoholic Fatty Liver Disease in Adult Patients with Subclinical Hypothyroidism Compared to Euthyroid: An Evidence-based Case Report.

Acta Med Indones 2019 Apr;51(2):179-188

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: hypothyroidism is a common concomitant disease of non-alcoholic fatty liver disease (NAFLD). Previous studies regarding the relationship between subclinical hypothyroidism and NAFLD showed conflicting results, ranging from a strong association to not significant one. This case report aimed to investigate the risk of developing NAFLD in subclinical hypothyroidism patients. Read More

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Human Tapeworm from Simalungun, Indonesia.

Acta Med Indones 2019 Apr;51(2):177-178

Faculty of Medicine, Islamic University of Sumatera Utara, Medan, Indonesia. Dr. Umar Zein Tropical Disease and Infection Clinic, Medan, Indonesia.

A 46-years-old man from Indonesia, resides in Nagori Dolok Village, Silau Kahaean Subdistrict, Simalungun District, Sumatra Utara Province, had of spontaneous discharge of tapeworm segments (proglottids) from anus almost every day for ten years. There were 1-5 segments which can move actively discharge per day. Although he feels embarrassed about the condition, no significant symptoms were found, and physical examination was within normal limits. Read More

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April 2019
1 Read

Subclinical Atherosclerosis in Young Adult Population with First Degree Relatives of Type 2 Diabetes Mellitus.

Acta Med Indones 2019 Apr;51(2):169-176

Faculty of Medicine, Universitas Indonesia.

Cardiovascular disease (CVD) remain a leading cause of death globally. The concept of acute myocardial infarction in young adults was uncommon. Atherosclerosis is the leading cause of CVD, including myocardial infarction, stroke, heart failure and peripheral artery disease. Read More

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An 18-Year-Old Man with Idiopathic Non-cirrhotic Portal Hypertension.

Acta Med Indones 2019 Apr;51(2):165-168

Department of Internal Medicine, Faculty of Medicine, University of Brawijaya - Saiful Anwar Hospital, Malang, Indonesia..

Non-Cirrhotic Portal Hypertension (NCPH) is a rare cause of hematemesis and melena. Like in cirrhotic patient, hematemesis in NCPH patient was caused by rupture of esophageal varices. But unlike in cirrhotic patient, in NCPH there are no sign of liver failure, because liver physiology is still normal. Read More

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April 2019
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Adult-onset Still's Disease as a Differential Diagnosis in Prolonged Fever: Diagnosis and Treatment Experience.

Acta Med Indones 2019 Apr;51(2):158-164

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Adult onset Still's disease is a rare systemic disease that may involve many organs and may mimick many disease such as infection, autoimmune disease, and also malignancy. The diagnostic approach and treatment strategies have not been well established due to its rarity; however, there are some diagnostic criteria that may help. We present a case of 36-year old man who experienced high prolonged fever which firstly thought as infection. Read More

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April 2019
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Characteristics of Palliative Patients, Insights of Patients and Families, and the Impact of Estimated Survival Time on Therapy Decisions.

Acta Med Indones 2019 Apr;51(2):151-157

Division of Psychosomatic and Paliative Medicine. Departement of Internal Medicine. Universitas Indonesia.

Background: chronic and terminal diseases require holistic therapy that covers the biopsychosocial aspect, and it can be found in palliative therapy. Patients who receive palliative therapy exhibit very diverse profiles. As such, researchers are keen to study the general characteristics of palliative patients. Read More

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Survival Rate of Cervical Cancer in National Referral Hospital in 2012 - 2014.

Acta Med Indones 2019 Apr;51(2):145-150

Department of Obstetrics and Gynaecology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia..

Background: cervical cancer is the third leading cause of female deaths worldwide, and it is the leading cause of female deaths in developing countries. A routine survival evaluation is required to imply the result of the treatment. The aim of this study was to determine the cervical cancer patient survival rate at the Cipto Mangunkusumo hospital as national referral hospital in Indonesia. Read More

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