790 results match your criteria Acta medica Indonesiana[Journal]


Current Practice of Hepatocellular Carcinoma Surveillance.

Acta Med Indones 2018 Oct;50(4):353-360

Gastroenterology and Hepatology Department, Dharmais National Cancer Center Hospital, Jakarta, Indonesia.

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. This is due to the heterogeneity of the tumor biology and lack of curative treatment options. The most significant prognostic factor is detection at early stage and thus, surveillance strategies are of high importance. Read More

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October 2018

Radiofrequency Ablation versus Resection in Large Single Nodule of Hepatocellular Carcinoma: an Evidence-based Case Report.

Acta Med Indones 2018 Oct;50(4):346-352

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: nowadays, radiofrequency ablation (RFA) is applied widely as an alternative therapy of resection in patient with hepatocellular carcinoma (HCC). Moreover, in single nodule with size of less than 2 cm, RFA can be the primary treatment. Although resection is the main treatment and one of the curative treatments in nodule meeting Milan criteria, it needs consideritation of the surgery risk stratification. Read More

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October 2018
10 Reads

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

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October 2018
12 Reads

Insulin Resistance in Gastroesophageal Reflux Disease.

Acta Med Indones 2018 Oct;50(4):336-342

Faculty of Medicine Universitas Indonesia.

Insulin resistance is the disturbance of glucose regulation characterized by higher insulin level. In clinical context, insulin resistance can manifest as abnormalities that are related with cardiovascular event risk, known as metabolic syndrome. Several studies had reported that insulin resistance was associated with erosive esophagitis in patients with gastroesophageal reflux disease (GERD). Read More

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October 2018
11 Reads

Acute Appendicitis in a Patient with Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):332-335

Department of Internal Medicine, Faculty of Medicine, Airlanggan University - dr. Soetomo Hospital, Surabaya, Indonesia.

Systemic lupus erythematosus (SLE) is a chronic excacerbative autoimmune disease with wide clinical spectrum. Gastrointestinal manifestasion is a frequent clinical manifestasion seen in SLE. Management with glucocorticoid and non-steroid anti-inflammatory drugs (NSAID) can mask the gastrointestinal symptoms in patient with SLE. Read More

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October 2018
8 Reads

Hypertension Despite Dehydration in an Adolescent with Diabetic Ketoacidosis.

Acta Med Indones 2018 Oct;50(4):328-331

Endocrine and Metabolic Unit, Department of Child Health, University of Benin Teaching Hospital, Benin City, Nigeria.

In general, information on blood pressure changes in diabetic ketoacidosis in paediatric population is very scarce. Our aim was to report a case of severe DKA in an adolescent girl who unexpectedly had hypertension rather than hypotension.A 17-year-old girl presented in our Children's Emergency Unit with complaints of excessive eating for 6 weeks, excessive urination for 2 weeks, fever for 1 week, vomiting for 4 days, difficulty with breathing for one day and unresponsiveness to calls for 3 hours. Read More

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October 2018
8 Reads

Association of Periodontitis and Arterial Stiffness in Type 2 Diabetic Patients.

Acta Med Indones 2018 Oct;50(4):320-327

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: periodontitis is a major cause of chronic infection in diabetic patients. Diabetic patients have four-fold risk of having cardiovascular disease. Chronic inflammation caused by periodontitis, a non-traditional cardiovascular risk factor is widely known to play a major role in atherogenesis. Read More

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October 2018
14 Reads

Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population.

Acta Med Indones 2018 Oct;50(4):314-319

Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya - Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia.

Background: diabetic nephropathy (DN) is the leading cause of blood dialysis worldwide and a major etiology of End-Stage Renal Disease cases in Indonesia. Previous studies showed a relevant link between A1166C polymorphism of Angiotensin II Type-1 Receptor (AT1R) gene and glomerular hyper-filtration as a part of pathogenesis of DN. The aim of this study was to elaborate the association between A1166C AT1R polymorphism and susceptibility of individual with type-2 diabetes to DN in Malay Indonesian population. Read More

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October 2018
12 Reads

The Association Between Parents History of Type 2 Diabetes with Metabolic Syndrome Component and Insulin Resistance in Non-Diabetic Young Adult Male.

Acta Med Indones 2018 Oct;50(4):309-313

Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: the familial nature of type 2 diabetes is manifested by the presence of insulin resistance in non-diabetic first degree relatives. Most of these studies have been performed in middle-aged and there is only few published studies in young age individuals and adolescents. This study aimed to determine the relationship between parents history of type-2 diabetes with metabolic syndrome component and insulin resistance in adolescent non-diabetic subjects. Read More

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October 2018
10 Reads

Exercise Intervention for Chronic Pain Management, Muscle Strengthening, and Functional Score in Obese Patients with Chronic Musculoskeletal Pain: A Systematic Review and Meta-analysis.

Acta Med Indones 2018 Oct;50(4):299-308

Departement of Physical Medicine and Rehabilitation, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: obesity and osteoarthritis have strong inter-relationship with multi-factorial mechanism that caused pain and leads to decreased quality of life. Exercise has been identified as prevention and management against obesity and joint pain. This systematic review aims to assess the effect between exercises compared to diet group for chronic pain management, physical and mental function in obese patients with chronic musculoskeletal problem. Read More

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October 2018
7 Reads

Non-Small Cell Lung Carcinoma in Women: A Retrospective Cohort Study in Indonesia.

Acta Med Indones 2018 Oct;50(4):291-298

Division of Hematology and Medical Oncology, Dept. of Internal Medicine, Dharmais Cancer Hospital, Jakarta, Indonesia.

Background: the increasing incidence of lung cancer in female patients has been observed in Indonesia. Lung cancer in female might have different biology process than male, but it has never been evaluated in Indonesia. This study aimed to know characteristics and survival of female patients with non-small-cell lung carcinoma (NSCLC) in Dharmais National Cancer Centre Hospital. Read More

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October 2018
9 Reads

Kidney Disease Profiles Among Adolescents In Indonesia.

Acta Med Indones 2018 Oct;50(4):283-290

Department of Child Health, Faculty of Medicine, Universitas Indonesia.

Background: Each kidney injury may develop into chronic kidney disease (CKD) and end stage renal disease (ESRD) that associates with high mortality and socio-economic burden. There is limited data about clinical characteristics of children having CKD in developing countries, espesially in Indonesia.

Objective: To describe clinical profiles and characteristics of kidney diseases in adolescents aged 15-18 years. Read More

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October 2018
10 Reads

Comparison of Survival Prediction with Single versus Combination Use of Microcirculation End Point Resuscitation in Sepsis and Septic Shock.

Acta Med Indones 2018 Oct;50(4):275-282

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.

Background: lactate clearance and central venous oxygen saturation (ScvO2) are two methods for determining tissue oxygenation adequacy. There is a controversy regarding method better associates with and predicts sepsis and septic shock patients' mortality. This study address the association of achieving one or two targets of microcirculatory resuscitation endpoints and early mortality in sepsis and septic shock. Read More

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October 2018
3 Reads

The Emergence of Non-communicable Disease in Indonesia.

Authors:
Dyah Purnamasari

Acta Med Indones 2018 Oct;50(4):273-274

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Based on data from the Indonesian Ministry of Health Information Center, the estimated population of Indonesia in 2016 was approximately 258,704,986 people, consisted of 129,988,690 men and 128,716,296 women. This number of Indonesian population represents young population since the proportion of population aged 0-14 years is more than that aged >14 years. Meanwhile, the proportion of population aged 50 years and above is significantly reduced, which is thought to be due to high mortality rate in the middle-aged population. Read More

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October 2018
19 Reads

Adult Diphtheria Vaccination.

Authors:
Iris Rengganis

Acta Med Indones 2018 Jul;50(3):268-272

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Low adult vaccination coverage in Indonesia may contribute to a recent outbreak of diphtheria in Indonesia. Although well known as a pediatric vaccine, diphtheria vaccination should be administered as booster to adolescence and adults for longer prevention. Adult vaccine differs from pediatric vaccine but have similar protection. Read More

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July 2018
1 Read

Plant-based Diet for HbA1c Reduction in Type 2 Diabetes Mellitus: an Evidence-based Case Report.

Acta Med Indones 2018 Jul;50(3):260-267

Faculty of Medicine Universitas Indonesia, Jakarta Indonesia.

Background: diabetes has become a major public health concern with an estimated 180 million cases worldwide. Nutritional changes are one of the key aspects in the management of type 2 diabetes mellitus. Previous studies have suggested an association between vegetarian diets and improvements in glycemic control in type 2 diabetes mellitus, however the relationship is not well established. Read More

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An Interesting Case of Hepatic Adrenocortical Carcinoma.

Acta Med Indones 2018 Jul;50(3):257-259

Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia.

Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1. Read More

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July 2018
13 Reads

Effect of Uric Acid on Blood Glucose Levels.

Acta Med Indones 2018 Jul;50(3):253-256

Department of Internal Medicine, Faculty of Medicine, Brawijaya University - Saiful Anwar Hospital, Malang, Indonesia.

Uric acid as the final result of purine bases metabolism. In high level condition, uric acid enters the cell and act as oxidant, and acts as independent risk factor and predicts the incident of type 2 diabetes mellitus (T2DM). It may directly inactivate or through oxidative reaction that lower the nitric oxide (NO) level. Read More

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July 2018
2 Reads

Catheter-related Blood Stream Infection in a Patient with Hemodialysis.

Acta Med Indones 2018 Jul;50(3):244-252

Department of Clinical Pathology, Infectious Diseases Subdivision, Fatmawati Central General Hospital, Jakarta, Indonesia.

A 31-year-old patient came to visit the outpatient clinic at the hospital for his routine twice-weekly hemodialyis (HD) session. During HD, the patient suddenly developed a fever with shivering. At that time, a diagnosis of catheter-related blood stream infection (CR-BSI) was developed, HD catheter or the catheter double lumen (CDL) was uninstalled and the patient was hospitalized. Read More

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July 2018
1 Read

Intravenous Rituximab in Severe Refractory Primary Focal Segmental Glomerulosclerosis.

Acta Med Indones 2018 Jul;50(3):237-243

Department of Medicine,Universiti Kebangsaan Malaysia Medical Centre, Malaysia.

Managing primary or even secondary glomerulonephritis remains a challenge to many nephrologists. In primary focal segmental glomerulosclerosis (FSGS) with heavy proteinuria, renin aldosterone system blockade and high dose of oral prednisolone is the mainstay of treatment. Other immunosuppressive medications like Cyclophosphamide, Cyclosporine A and Mycophenolate Mofetil (MMF) are warranted if a complete remission is not achieved. Read More

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July 2018
15 Reads

Evaluation of Iron Overload Between Age Groups Using Magnetic Resonance Imaging and Its Correlation with Iron Profile in Transfusion-dependent Thalassemia.

Acta Med Indones 2018 Jul;50(3):230-236

Pediatric Hematology-Oncology Division, Department of Child Health, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: routine blood transfusion in transfusion-dependent-thalassemia (TDT) causes iron accumulation in various organ. Serum markers of iron overload, serum ferritin and transferrin saturation, are sensitive but not specific. MRI T2-star (T2*) is valuable for detecting iron level in organs. Read More

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July 2018
5 Reads

Comparison of Quality of Life between Patients Undergoing Chronic Hemodialysis with Reusable Dialyzer and Single-Use Dialyzer: A Retrospective Cohort Study.

Acta Med Indones 2018 Jul;50(3):222-229

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: in Indonesia, majority of hemodialysis centers use reusable dialyzer for cost efficiency reason. Currently, there is no available data regarding the quality of life of the end stage-renal disease patient'who use reusable dialyzer measured by a standardized questionnaire, as it was stated that at molecular level, reusable dialyzer could worsen leukocyte activity and could affect patients' complaints and symptoms.

Methods: this was a retrospective cohort study which involved 39 subjects. Read More

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July 2018
2 Reads

Effect of Alfacalcidol on Inflammatory markers and T Cell Subsets in Elderly with Frailty Syndrome: a Double Blind Randomized Controlled Trial.

Acta Med Indones 2018 Jul;50(3):215-221

1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia 2. Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: Alphacalcidol, a vitamin D analog, shows immune regulatory potency as it works on the macrophage and T cell to control inflammation and T cell dysregulation in elderly. None has been known about its effect on elderly with various states of frailty syndrome, which have different level of chronic low grade inflammation. This study aimed to determine the effect of alphacalcidol on inflammatory cytokines (IL-6, IL-10, g-IFN ) and T cell subsets (CD4/CD8 ratio and CD8+ CD28-) of elderly with various stages of frailty syndrome. Read More

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July 2018
12 Reads

A Clinical Trial on Biological Half Life of Bioactive Protein from Lumbricus rubellus, DLBS1033 in Healthy Volunteers.

Acta Med Indones 2018 Jul;50(3):208-214

Department of Pharmacology and Therapeutic, Medical Faculty Universitas Indonesia, Jakarta, Indonesia.

Background: DLBS1033 is a bioactive protein fraction extracted from Lumbricus rubellus, with fibrinogenolytic, fibrinolytic and anti-aggregation activities reported in an in vitro study. Plasma half-life is an important parameter to calculate its dose. This study was conducted to evaluate the biological half-life of DLBS1033 by measuring serial plasmin-antiplasmin (PAP) complex. Read More

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July 2018
16 Reads

Efficacy of Additional Solifenacin Succinate Therapy for Storage Symptoms in Females with Uncomplicated Lower Urinary Tract Infection: The SOLUTION Randomized Controlled Trial.

Acta Med Indones 2018 Jul;50(3):200-207

Department of Urology Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: urinary tract infection (UTI) is often treated in daily practice as overactive bladder (OAB) by giving anticholinergic, the recommended treatment options of OAB. However, anticholinergic application for UTI symptoms relief has never been investigated. To our knowledge, this study was the first randomized trial which investigate anticholinergic use for UTI treatment. Read More

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July 2018
2 Reads

Gallbladder Wall Thickening for Early Detection of Plasma Leakage in Dengue Infected Adult Patients.

Acta Med Indones 2018 Jul;50(3):193-199

Departement of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: plasma leakage is defined as ≥20% elevation of hematocrit from baseline or decrease in convalescence or evidence of plasma leakage such as pleural effusion, ascites or hypoproteinaemia/hypoalbuminaemia. These signs of plasma leakage, in the early phase, are usually difficult to ascertain by physical examination and laboratory tests where the patient is only reflecting a mild degree of plasma leakage. This study aimed to investigate whether gallbladder wall thickening (GBWT) in the early phase of the disease can be used to detect the occurrence of plasma leakage in dengue patients. Read More

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July 2018
1 Read

Diagnostic Accuracy of Platelet/Lymphocyte Ratio for Screening Complex Coronary Lesion in Different Age Group of Patients with Acute Coronary Syndrome.

Acta Med Indones 2018 Jul;50(3):185-192

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: with the increasing number of patients with acute coronary syndrome (ACS) with complex coronary lesion and the increasing needs of coronary artery bypass grafting (CABG) procedures, there is an increasing need for a tool to perform early stratification in high-risk patients, which can be used in daily clinical practice, even at first-line health care facilities setting in Indonesia. It is expected that early stratification of high-risk patients can reduce morbidity and mortality rate in patients with ACS. This study aimed to identify diagnostic accuracy of platelet/lymphocyte ratio (PLR) and the optimum cut-off point of PLR as a screening tool for identifying a complex coronary lesion in patients ≤45 and >45 years old. Read More

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Early Detection of Plasma Leakage in Dengue Hemorrhagic Fever.

Authors:
Erni J Nelwan

Acta Med Indones 2018 Jul;50(3):183-184

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Dengue viral infection remains a major public health problem. As many as 400 million people are infected yearly. Even though the vaccine is available, the use of dengue vaccine is still limited due to some concerns. Read More

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July 2018
4 Reads

Current Diagnosis and Management of Graves' Disease.

Acta Med Indones 2018 Apr;50(2):177-182

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia..

Graves' disease is an autoimmune disorder which affect thyroid gland. Graves' disease is the most common cause of hyperthyroidism and thyrotoxicosis. Understanding of disease pathophysiology, diagnostic and treatment strategies, and prevention of disease relapse are important for all clinicians especially internal medicine specialist to give optimal and comprehensive management for Graves' disease patients. Read More

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April 2018
13 Reads

Comparison of Deferiprone to Deferasirox and Deferoxamine to Cardiac and Hepatic T2* MRI in Thalassemia Patients: Evidence-based Case Report.

Acta Med Indones 2018 Apr;50(2):168-176

Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital..

Background: there are currently three iron chelator readily available for patients Indonesia; deferiprone/DFP (branded as Ferriprox), deferasirox/DFX (branded as Exjade) and deferoxamine/DFO (branded as Desferal). This study aims to determine which iron chelator is the most efficient in reducing cardiac and hepatic iron overload (measured by means of T2* MRI).

Methods: journal search with determined MeSH term was done in PubMed and Scopus. Read More

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April 2018
21 Reads

Double Culprits in a Patient with ST Elevation Myocardial Infarction: A Challenging But Rewarding Case.

Acta Med Indones 2018 Apr;50(2):165-167

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Myocardial infarction simultaneously involving two or more culprit lesions is extremely rare and usually has a poor clinical outcomes including mortality. Management of this complicated condition is challenging and limited time. Nevertheless, autopsy studies revealed that thrombotic occlusion of more than one major epicardium coronary artery is not uncommon. Read More

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April 2018
7 Reads

Obesity as the Sequel of Childhood Stunting: Ghrelin and GHSR Gene Polymorphism Explained.

Acta Med Indones 2018 Apr;50(2):159-164

Department of Nutrition and Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Stunting or short stature in children is a significant nutritional problem in developing and underdeveloped countries. Stunting during childhood might affect brain development and impair development cognitive function. Additionally, this condition associated with the increased risk for obesity during adulthood. Read More

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April 2018
18 Reads

A Chronic Lymphocytic Leukemia Patient with Progressive Multifocal Leukoencephalopathy Caused by John Cunningham Virus.

Acta Med Indones 2018 Apr;50(2):151-158

Department of Internal Medicine, Faculty of Medicine Airlangga University - dr. Soetomo Hospital, Surabaya, Indonesia.

Progressive multifocal leukoencephalopathy (PML) is a rare but fatal disease leading to severe neurological impairments. PML is a clinical manifestation, which is usually associated with John Cunningham virus (JCV) infection. It is also correlated to malignancies that mainly include hematologic malignancies such as chronic lymphocytic leukemia (CLL). Read More

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April 2018
6 Reads

The Coexistence of Systemic Lupus Erythematosus and Psoriasis: Is It Possible?

Acta Med Indones 2018 Apr;50(2):144-150

Department of Internal Medicine, Faculty of Medicine, Airlanggan University - dr. Soetomo Hospital, Surabaya, Indonesia.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with various clinical disorders and frequent exacerbations. Psoriasis vulgaris is a common skin disorder which affect 1-3% of general populations. The pathophysiology regarding the coexistence of these diseases is not fully understood. Read More

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April 2018
4 Reads

The Benefit of Interferon-Gamma Release Assay for Diagnosis of Extrapulmonary Tuberculosis.

Acta Med Indones 2018 Apr;50(2):138-143

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: there are many researches about IGRA in extrapulmonary Tuberculosis (TB), but there only few data from developing countries. This was the first research about the utility of IGRA in extrapulmonary TB performed in Indonesia as developing country with the 2nd most frequent of TB cases in the world. This study aimed to identify the advantage of IGRA examination in diagnosing extrapulmonary TB. Read More

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Correlation Between Vitreous Advanced Glycation End Products, and D-dimer with Blood HbA1c Levels in Proliferative Diabetic Retinopathy.

Acta Med Indones 2018 Apr;50(2):132-137

Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta.

Background: proliferative diabetic retinopathy (DR) is an advanced form of DR that eventually could lead to blindness. Levels of vitreous advanced glycation end products (AGEs) and D-dimer may reflect the pathological changes in the retina, but only few studies have assessed their correlation with blood hemoglobin A1C (HbA1c) levels. This study aimed to find the association between blood HbA1c levels with vitreous AGEs and D-dimer levels in patients with proliferative DR. Read More

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April 2018
22 Reads

Comparison of Specific Immunoglobulin E with the Skin Prick Test in the Diagnosis of House Dust Mites and Cockroach Sensitization in Patients with Asthma and/or Allergic Rhinitis.

Acta Med Indones 2018 Apr;50(2):125-131

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: nowadays, specific IgE measurement has been conducted in Indonesia, however there is still lack of data regarding diagnostic test to detect inhalant allergen in patients with respiratory allergies.This study aimed to determine the accuracy of specific IgE test in diagnosing specific sensitization of inhalant allergen in patients with respiratory allergies.

Methods: this was a cross sectional study in patients with respiratory allergies and part of epidemiology study regarding to specific IgE sensitization in Allergy-Immunollogy Division, Cipto Mangunkusumo Hospital, Jakarta within November-December 2016. Read More

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April 2018
2 Reads

7 Years Experience of Living Donor Kidney Transplantation in Indonesia: A Retrospective Cohort Study.

Acta Med Indones 2018 Apr;50(2):119-124

Universitas Indonesia.

Background: kidney transplantation has been developing rapidly in Indonesia in recent years, yet data on transplants' characteristics and survival is still unavailable. In Indonesia, only living donors are permitted. Living donor are advantageous, but challenging to recruit. Read More

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April 2018
17 Reads

Diagnostic Determinants of Proliferative Lupus Nephritis Based on Clinical and Laboratory Parameters: A Diagnostic Study.

Acta Med Indones 2018 Apr;50(2):110-118

Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: proliferative lupus nephritis (LN) has higher prevalence and worse prognosis than non-proliferative LN. Renal biopsy plays an important role in diagnosis and therapy of LN, but there are some obstacles in its implementation. A diagnostic scoring system for proliferative LN is necessary, especially for cases in which renal biopsy cannot be performed. Read More

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CD30, CD15, CD50, and PAX5 Expressions as Diagnostic Markers for Hodgkin Lymphoma (HL) and Systemic Anaplastic Large Cell Lymphoma (sALCL).

Acta Med Indones 2018 Apr;50(2):104-109

Division of Hematology and Medical Oncology, Dharmais Hospital National Cancer Center, Jakarta, Indonesia.

Background: the expression of CD30, CD15, CD50, and PAX5 are used to help in confirming diagnosis of HL and sALCL; however data on the proportion of these markers have not been available. The study was aimed to identify the proportion of CD30, CD15, CD50 and PAX5 expressions and characteristics of patients with HL and sALCL at Dharmais National Cancer Center Hospital between 2005 and 2015.

Methods: a retrospective observational study was conducted using data from medical records and histopathological results of HL and sALCL adult patients who sought treatment at the hospital between 2005 and 2015. Read More

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April 2018
4 Reads

Cardiovascular Disease Risk Factors Among Blue and White-collar Workers in Indonesia.

Acta Med Indones 2018 Apr;50(2):96-103

Department of Epidemiology, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia.

Background: cardiovascular diseases (CVD) is the most common cause of death in Indonesia. We aimed to examine risks of CVD in workers aged 40 to 69 year related to their occupational status.

Methods: a cross-sectional study in all provinces of Indonesia. Read More

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The Role of Reed-Sternberg CD30 Receptor and Lymphocytes in Pathogenesis of Disease and Its Implication for Treatment.

Authors:
Ikhwan Rinaldi

Acta Med Indones 2018 Apr;50(2):93-95

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Hodgkin lymphoma is a cancer that can be cured using standard chemotherapy with or without radiation. Although it accounts for only 0.6% of all malignancy worldwide, but it usually affects young adults with median age of 38 years. Read More

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April 2018
3 Reads

Measurement of Health-Related Quality of Life in Patients with Functional Dyspepsia.

Acta Med Indones 2018 Jan;50(1):88-92

Departement of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

In up to 80% of dyspepsia patients who consult a physician in the hospital, dyspepsia is considered to be functional dyspepsia. Although not associated with increased mortality, functional dyspepsia is a burden at both the community and national levels because it can cause physical, mental, and social distress that can affect a patient's quality of life. Health-related quality of life (HRQOL) is a multidimensional construct comprising at least three broad domains-physical, psychological, and social functioning-which can all be affected by a disease and its treatment. Read More

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January 2018

The Effectiveness of Aerobic Exercise in Improving Peripheral Nerve Functions in Type 2 Diabetes Mellitus: An Evidence Based Case Report.

Acta Med Indones 2018 Jan;50(1):82-87

Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: peripheral neuropathy is known as one of most common complication in diabetes mellitus type 2 patient. This complication is caused by uncontrolled condition of blood glucose level in long periode. Regular physical activity in moderate to high intensity is beneficial in management of diabetes mellitus. Read More

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January 2018

Chromobacterium violaceum: The Deadly Sepsis.

Acta Med Indones 2018 Jan;50(1):80-81

Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran-Hasan Sadikin Hospita, Bandung, Indonesia.

Chromobacterium violaceum is a Gram-negative facultatively anaerobic, oxidase-positive bacterium producing a dark violet antioxidant pigment called violacein. It is an opportunistic pathogen and has an ubiquitous distribution, mainly resides in water and soil of tropical and subtropical regions.An-18-year-old man referred to the emergency room with a 5-day history of progressively worsening swelling of the right cheek. Read More

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January 2018
1 Read

The Autoimmune Mechanism in Dengue Hemorrhagic Fever.

Acta Med Indones 2018 Jan;50(1):70-79

Department of Internal Medicine, Gatot Soebroto Central Army Hospital-Jakarta, Indonesia.

The immune response of dengue fever/dengue hemorrhagic fever is a series of immunopathogenesis processes starting from viral infection to the target on monocytes and macrophages. It may consequently cause a cascade of viremia in the circulation that stimulates the afferent, efferent, and effector mechanism by the interaction of the humoral and complement system. The cascade results in inflammatory substance that will affect capillary permeability and activate coagulation factors leading to further effects on endothelial level. Read More

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January 2018
1 Read

Ectopic Infra Orbital Nerves: Case Series of a Dangerous Normal Variant.

Acta Med Indones 2018 Jan;50(1):66-69

Rajiv Gandhi Medical College and Chatrapati Shivaji Maharaj Hospital, Kalwa, Thane, Maharashtra, India.

Normal variations in the paranasal sinus region are well documented in literature. We present five cases of a little known normal variant, which can have serious implications for the patient as well as the operating surgeon. An ectopic infra orbital nerve canal coursing through the maxillary sinus has rarely been described in imaging literature. Read More

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January 2018

Bilateral Giant Renal Angiomyolipoma in a Patient with Tuberous Sclerosis Complex: A Case Report.

Acta Med Indones 2018 Jan;50(1):61-65

Department of Surgery, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.

Tuberous sclerosis complex (TSC) has several renal manifestations including angiomyolipomas (AML) and renal epithelial neoplasms. A bilateral giant renal AML is extremely rare. We report a case of giant bilateral AML and discuss the diagnosis and treatment of it. Read More

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January 2018
7 Reads

Association Between Arg753Gln and Arg677Trp Polymorphisms of TLR2 Gene with Active Pulmonary Tuberculosis in an Indonesian Population.

Acta Med Indones 2018 Jan;50(1):53-60

Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia.

Background: Toll-like receptor is a pattern recognition receptor (PRR) that recognize pathogen-associated molecular pattern (PAMP) in a microorganism. Macrophages recognize the presence of mycobacteria through Toll-Like Receptor 2 (TLR2) and signaling further lead to the production of cytokines, both proinflammatory TNF-α, IL-1β, IL-6, IL-12, IL-15, IL-18 and IFN-γ, as well as anti-inflammatory IL4, IL-10 and TGF-β. TLR2 gene polymorphism is strongly determined by ethnicity and geography. Read More

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January 2018
9 Reads

Diabetic Ketoacidosis in Adolescents and Children: A Prospective Study of Blood versus Urine Ketones in Monitoring Therapeutic Response.

Acta Med Indones 2018 Jan;50(1):46-52

Endocrinology Division, Department of Child Health, Faculty of Medicine, University of Indonesia-Cipto Mangunkusumo Hospital.

Background: diabetic ketoacidosis (DKA) is a potentially lethal complication of diabetes mellitus (DM). There is no study in Indonesia that compares the much-preferred capillary beta hydroxybutirate (β-OHB) measurement to urine acetoacetate in monitoring therapeutic response of DKA in adolescents.

Methods: a prospective study of 37 adolescents and children with DKA in Cipto Mangunkusumo Hospital was done between June 2006 and March 2011. Read More

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January 2018
6 Reads