672,862 results match your criteria Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH[Journal]


Plasminogen deficiency does not prevent sodium retention in a genetic mouse model of experimental nephrotic syndrome.

Acta Physiol (Oxf) 2020 May 26. Epub 2020 May 26.

Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, University Hospital Tübingen, Germany.

Aim: Sodium retention is the hallmark of nephrotic syndrome (NS) and mediated by the proteolytic activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases. Plasmin is highly abundant in nephrotic urine and has been proposed to be the principal serine protease responsible for ENaC activation in NS. However, a proof of the essential role of plasmin in experimental NS is lacking. Read More

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http://dx.doi.org/10.1111/apha.13512DOI Listing

Primary Synovial Sarcoma of the Thyroid: Challenges in Cytologic Diagnosis and Review of the Literature.

Acta Cytol 2020 May 26:1-9. Epub 2020 May 26.

Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA.

Background: Primary synovial sarcoma (SS) of the thyroid (PSST) is extremely rare. Its differential diagnosis from other neoplasms is essential since it has different management protocols and prognosis.

Case: A 26-year-old man with a 4. Read More

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http://dx.doi.org/10.1159/000507312DOI Listing

COVID-19 and Nasal Cytobrush Cytology.

Acta Cytol 2020 May 26:1-2. Epub 2020 May 26.

Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.

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http://dx.doi.org/10.1159/000508768DOI Listing

A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology: The Sydney System.

Acta Cytol 2020 May 26:1-17. Epub 2020 May 26.

Department of Medicine and Surgery, Università degli Studi di Salerno, Fisciano, Salerno, Italy,

Background: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC.

Methods: The committee members prepared a document that has circulated among them five times; the final text has been approved by all the participants. Read More

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http://dx.doi.org/10.1159/000506497DOI Listing

Sequence matters: Combining Prolonged Exposure and EMDR therapy for PTSD.

Psychiatry Res 2020 May 16;290:113032. Epub 2020 May 16.

Research department PSYTREC, Bilthoven, The Netherlands; Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, The Netherlands; School of Health Sciences, Salford University, Manchester, United Kingdom; Institute of Health and Society, University of Worcester, United Kingdom; School of Psychology, Queen's University, Belfast Northern Ireland. Electronic address:

Objective: Investigating the influence of the sequence in which two evidence-based trauma-focused treatments are offered to PTSD-patients.

Methods: PTSD-patients were treated using an intensive eight-day treatment program, combining Prolonged Exposure (PE) and EMDR therapy. Forty-four patients received a PE session in the morning and an EMDR session in the afternoon, while 62 patients received the reversed sequence (EMDR followed by PE). Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113032DOI Listing

Functional BOD-Ad-Cmyc@BSA complex nanosensor for Cu(II) and the detection of live E. coli.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 14;239:118483. Epub 2020 May 14.

School of the Environment and Safety Engineering, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jingkou District, Xuefu Road, 212013, People's Republic of China. Electronic address:

Escherichia coli (E. coli) is abundantly present in nature. It is generally harmless to humans but some strains have been deemed very dangerous. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118483DOI Listing

Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells.

Biochim Biophys Acta Mol Basis Dis 2020 May 23:165843. Epub 2020 May 23.

R S Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO, Vision Research Foundation, Sankara Nethralaya, College Road, Nungambakkam, Chennai - 6, India. Electronic address:

Age related macular degeneration (AMD) is a multifactorial disease with genetic, biochemical and environmental risk factors. We observed a significant increase in copper levels in choroid-RPE from donor eyeballs with AMD. Adult retinal pigment epithelial cells (ARPE19 cells) exposed to copper in-vitro showed a 2-fold increase in copper influx transporter CTR1 and copper uptake at 50 μM concentration. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165843DOI Listing

Self-assembling Prodrug Nanotherapeutics for Synergistic Tumor Targeted Drug Delivery.

Acta Biomater 2020 May 23. Epub 2020 May 23.

Skaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona, 85721, United States; NCI-designated University of Arizona Comprehensive Cancer Center, Tucson, Arizona, 85721, United States; Southwest Environmental Health Sciences Center, The University of Arizona, Tucson, 85721, United States; BIO5 Institute, The University of Arizona, Tucson, Arizona, 85721, United States. Electronic address:

Self-assembling prodrugs represents a robust and effective nanotherapeutic approach for delivering poorly soluble anticancer drugs. With numerous intrinsic advantages, self-assembling prodrugs possess the maximum drug loading capacity, controlled drug release kinetics, prolonged blood circulation, and preferential tumor accumulation based on the enhanced permeability and retention (EPR) effect. These prodrug conjugates allow for efficient self-assembly into nanodrugs with the potential of encapsulating other therapeutic agents that have different molecular targets, enabling simultaneous temporal-spatial release of drugs for synergistic antitumor efficacy with reduced systemic side effects. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.026DOI Listing

Glycogen synthase kinase-3 signaling in cellular and behavioral responses to psychostimulant drugs.

Biochim Biophys Acta Mol Cell Res 2020 May 23:118746. Epub 2020 May 23.

Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address:

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase implicated in numerous physiological processes and cellular functions through its ability to regulate the function of many proteins, including transcription factors and structural proteins. GSK-3β has been demonstrated to function as a regulator of multiple behavioral processes induced by drugs of abuse, particularly psychostimulant drugs. In this review, we provide an overview of the regulation of GSK-3β activity produced by psychostimulants, and the role of GSK-3β signaling in psychostimulant-induced behaviors including drug reward, associative learning and memory which play a role in the maintenance of drug-seeking. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118746DOI Listing

How well do laboratories adhere to recommended guidelines for dyslipidaemia management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) Study.

Clin Chim Acta 2020 May 23. Epub 2020 May 23.

Department of Clinical Chemistry, HUSLAB, Helsinki University Hospital, Helsinki, Finland.

Background: The CArdiac MARker Guidelines Uptake in Europe Study (CAMARGUE) initiated by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) aims to survey the current use of evidence-based guidelines for dyslipidemia testing in Europe.

Methods: In 2019 a web-based questionnaire was distributed via EFLM National Societies to clinical laboratories in Europe. Questions covered pre-analytics, analytical methods, measurement units, flagging of decision thresholds, and use of decision-enhancing comments. Read More

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http://dx.doi.org/10.1016/j.cca.2020.05.038DOI Listing

An evidence for correlation between the glutathione S-transferase T1 (GSTT1) polymorphism and outcome of COVID-19.

Authors:
Mostafa Saadat

Clin Chim Acta 2020 May 23. Epub 2020 May 23.

Department of Biology, College of Sciences, Shiraz University, Shiraz 71467-13565, Iran.

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http://dx.doi.org/10.1016/j.cca.2020.05.041DOI Listing

Malaria transmission and individual variability of the naturally acquired IgG antibody against the Plasmodium vivax blood-stage antigen in an endemic area in Brazil.

Acta Trop 2020 May 23:105537. Epub 2020 May 23.

Universidade Federal do Pará, Instituto de Ciências Biológicas, CEP: 66075-110, Belém, Pará, Brazil.

Plasmodium vivax remains an important cause of malaria in South America and Asia, and analyses of the antibody immune response are being used to identify biomarker of parasite exposure. The IgG antibody naturally acquired predominantly occurs against targets on blood-stage parasites, including C-terminal of the merozoite surface protein 1 (MSP1-19). Epidemiological and immunological evidence has been showed that antibodies to malaria parasite antigens are lost in the absence of ongoing exposure. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105537DOI Listing

Arbovirus expansion: new species of culicids infected by the Chikungunya virus in an urban park of Brazil.

Acta Trop 2020 May 23:105538. Epub 2020 May 23.

Laboratory of Entomology Research, Department of Microbiology and Parasitology, Universidade Federal do Rio Grande do Norte, 59.078-970, Natal, Rio Grande do Norte, Brazil.

The Dengue, Zika and Chikungunya viruses have been spreading in tropical regions, causing epidemics with high morbidity rates and fatal cases. The aim of this study was to assess the diversity and abundance of culicid species and the presence of arboviruses in mosquitoes, at the epicenter of an epidemic outbreak that occurred in people living near an urban Atlantic Forest park. Mosquitoes were captured with a Shannon trap between 2 and 6 pm in seven months of 2019. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105538DOI Listing

The effect of hydrophobic alkyl sidechains on size and solution behaviors of nanodiscs formed by alternating styrene maleamic copolymer.

Biochim Biophys Acta Biomembr 2020 May 23:183360. Epub 2020 May 23.

Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address:

The development of amphipathic polymers, including various formulations of styrene-maleic acid (SMA) copolymers, has allowed the purification of increasing sizes and complexities of biological membrane protein assemblies in native nanodiscs. However, the factors determining the sizes and shapes of the resulting bio-nano particles remain unclear. Here, we show how grafting on short alkyl amine sidechains onto the polar residues leads to a broad set of nanoparticle sizes with improved solution behavior. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183360DOI Listing

Molecular organization in mixed SOPC and SDPC model membranes: Water permeability studies of polyunsaturated lipid bilayers.

Biochim Biophys Acta Biomembr 2020 May 23:183365. Epub 2020 May 23.

Department of Chemistry, Iona College, 715 North Avenue, New Rochelle, NY 10801, USA. Electronic address:

Polyunsaturated phospholipids in plasma membranes modulate order and dynamics of the lipid bilayer and influence integral membrane protein function. In this study, we investigate the effects of polyunsaturated fatty acid (PUFA) chains in phosphatidylcholine (PC) on osmotic water permeability and packing characteristics, using a droplet interface bilayer (DIB) as a model cell membrane. The lipid bilayer system is composed of mixtures of PC lipids with varying ratio of 1-stearoyl-2-oleoylphosphatidylcholine (SOPC, 18: 0-18:1 PC) to 1-stearoyl-2-docosahexaenoylphosphatidylcholine (SDPC, 18:0-22:6 PC). Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183365DOI Listing

Prevalence of retinitis pigmentosa in Singapore: the Singapore Epidemiology of Eye Diseases Study.

Acta Ophthalmol 2020 May 26. Epub 2020 May 26.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

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http://dx.doi.org/10.1111/aos.14483DOI Listing

Personalized medicine for the embryo and the fetus - Options in modern genetics influence preconception and prenatal choices.

Acta Obstet Gynecol Scand 2020 Jun;99(6):689-691

Center for Fetal Diagnostics, Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1111/aogs.13882DOI Listing

A sepsis risk calculator can decrease antibiotic exposure in neonatal early-onset sepsis screening.

Acta Paediatr 2020 May 26. Epub 2020 May 26.

Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.

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http://dx.doi.org/10.1111/apa.15332DOI Listing

Agreement between three-dimensional planimetry and mitral navigation method in the assessment of mitral valve area in rheumatic severe mitral stenosis.

Acta Cardiol 2020 May 26:1-7. Epub 2020 May 26.

Department of Cardiology, Medipol University Hospital, Istanbul, Turkey.

Rheumatic heart disease predisposes to structural changes in the mitral valve including commissural fusion and calcification with subsequent narrowing of the mitral valve orifice resulting in rheumatic mitral stenosis (RMS). To define the best therapeutic strategy, an accurate measurement of mitral valve area (MVA) for RMS is of paramount importance. The propose of the present study was to assess the agreement between the mitral navigation method (MVN) and three-dimensional (3D) planimetry in the assessment of MVA in patients with RMS. Read More

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http://dx.doi.org/10.1080/00015385.2020.1764208DOI Listing

Predictors of in-hospital mortality in patients with infective endocarditis.

Acta Cardiol 2020 May 26:1-8. Epub 2020 May 26.

Division of Cardiology, Department of Medicine II, Kansai Medical University, Osaka, Japan.

Infective endocarditis is a serious septic disease, and the epidemiological profile has changed over the last decade. However, there is a paucity of data regarding the current outcome and predictor of in-hospital mortality in patients with infective endocarditis. Consecutive patients diagnosed as infective endocarditis based on the modified Duke criteria at Kansai Medical University hospital from January 2006 to June 2019 were prospectively included. Read More

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http://dx.doi.org/10.1080/00015385.2020.1767368DOI Listing

Q fever endocarditis.

Acta Cardiol 2020 May 26:1-2. Epub 2020 May 26.

Department of Cardiovascular Disease, CHU UCL Namur, Université Catholique de Louvain, Yvoir, Belgium.

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http://dx.doi.org/10.1080/00015385.2020.1762028DOI Listing

Impact of plaque burden and composition on coronary slow flow in ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: intravascular ultrasound and virtual histology analysis.

Acta Cardiol 2020 May 26:1-11. Epub 2020 May 26.

Department of Cardiology, Velammal Medical College Hospital and Research Institute, Madurai, India.

Coronary slow flow (SF) is an important complication of percutaneous coronary intervention (PCI) associated with poor prognosis. The aim was to assess grey-scale intravascular ultrasound (IVUS) and virtual histology (VH-IVUS) characteristics of culprit lesion in ST-elevation myocardial infarction (STEMI). A total of 295 consecutive patients with STEMI underwent coronary angiogram and IVUS. Read More

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http://dx.doi.org/10.1080/00015385.2020.1767842DOI Listing

18F-FDG micro-PET/CT for intra-operative margin assessment during breast-conserving surgery.

Acta Chir Belg 2020 May 26:1-22. Epub 2020 May 26.

Department of Gynecology, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.

Positive surgical margins for invasive breast cancer (BC) treated with breast-conserving surgery (BCS) are defined as ink on tumor. The rate of positive margins are approximately 20%, since a time- and cost-effective method for margin assessment is lacking. In this study, we investigated margin status by intra-operative imaging using high-resolution F-fluoro-deoxyglucose (FDG) positron emission tomography (PET) and X-ray computed tomography (CT). Read More

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A new standard radiographic reference for proximal fibular height in children.

Acta Orthop 2020 May 26:1-6. Epub 2020 May 26.

Children's Orthopedics, Deformity Reconstruction and Foot Surgery, University Hospital of Muenster.

Background and purpose - To date there is a lack of studies defining the anatomical position of the proximal fibula. This is especially relevant when planning surgical interventions affecting the knee joint such as permanent or temporary epiphysiodesis to correct leg length discrepancies or angular deformities in growing patients. The goal of this study is to establish a standardized measurement technique and radiological reference values for the position of the proximal fibula in children. Read More

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http://dx.doi.org/10.1080/17453674.2020.1769378DOI Listing

Implant migration and bone mineral density measured simultaneously by low-dose CT scans: a 2-year study on 17 acetabular revisions with impaction bone grafting.

Acta Orthop 2020 May 26:1-5. Epub 2020 May 26.

Department of Orthopedics Gävle Hospital, Center for Research & Development, Uppsala University/County Council of Gävleborg, Sweden.

Background and purpose - Early postoperative implant migration predicts failure of joint replacements. Bone mineral density reflects bone quality and bone-graft incorporation. Implant migration and bone densitometry analysis usually require special equipment. Read More

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http://dx.doi.org/10.1080/17453674.2020.1769295DOI Listing

Effective radiation dose in radiostereometric analysis of the hip.

Acta Orthop 2020 May 26:1-9. Epub 2020 May 26.

Department of Orthopaedic Surgery, Reinier de Graaf Groep, Delft, The Netherlands.

Background and purpose - Radiostereometric analysis (RSA) is the gold standard to study micromotion of joint replacements. RSA requires the acquisition of additional radiographs increasing the radiation dose of patients included in RSA studies. It is important to keep this dose as low as possible. Read More

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http://dx.doi.org/10.1080/17453674.2020.1767443DOI Listing

Aggressive fibromatosis of the upper arm: an unusual cause of radial nerve paresis.

Acta Neurol Belg 2020 May 25. Epub 2020 May 25.

Department of Radiology, AZ Sint-Maarten Mechelen, Liersesteenweg 435, 2800, Mechelen, Belgium.

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http://dx.doi.org/10.1007/s13760-020-01386-3DOI Listing

Author's response to letter from Drs. Vetrano, Devigili, and Nazzi.

Acta Neurochir (Wien) 2020 May 25. Epub 2020 May 25.

Friendly Foot Care, PC, 50 W. 94th Place, Crown Point, IN, 46307, USA.

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http://dx.doi.org/10.1007/s00701-020-04411-9DOI Listing

Drinking water temperature affects cognitive function and progression of Alzheimer's disease in a mouse model.

Acta Pharmacol Sin 2020 May 25. Epub 2020 May 25.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Lifestyle factors may affect mental health and play a critical role in the development of neurodegenerative diseases including Alzheimer's disease (AD). However, whether the temperatures of daily beverages have any impact on cognitive function and AD development has never been studied. In this study, we investigated the effects of daily drinking water temperatures on cognitive function and AD development and progression in mice and the underlying mechanisms. Read More

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http://dx.doi.org/10.1038/s41401-020-0407-5DOI Listing

Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.

Acta Pharmacol Sin 2020 May 25. Epub 2020 May 25.

The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.

Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, but there is no effective drug available for GBM. Avasimibe is a potent inhibitor of acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1), which was used to treat atherosclerosis. Experimental evidence and bioinformatics have shown that avasimibe has anticancer activity. Read More

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http://dx.doi.org/10.1038/s41401-020-0404-8DOI Listing

Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.

Acta Pharmacol Sin 2020 May 25. Epub 2020 May 25.

Department of Pharmacology and Biochemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.

High infiltration of M2-polarized macrophages in the primary tumor indicates unfavorable prognosis and poor overall survival in the patients with triple-negative breast cancer (TNBC). Thus, reversing M2-polarized tumor-associated macrophages in the tumors has been considered as a potential therapeutic strategy for TNBC. Sphingomyelin synthase 2 (SMS2) is the key enzyme for sphingomyelin production, which plays an important role in plasma membrane integrity and function. Read More

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http://dx.doi.org/10.1038/s41401-020-0419-1DOI Listing

Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism.

Acta Pharmacol Sin 2020 May 25. Epub 2020 May 25.

Department of Chemistry, Washington State University, Pullman, WA, 99164, USA.

We have recently developed an enzyme-directed immunostimulant (EDI) prodrug motif, which is metabolized to active immunostimulant by cancer cells and, following drug efflux, activates nearby immune cells, resulting in immunogenicity. In this study, we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod (a Toll-like receptor 7/8 agonist) covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase, α-mannosidase, or β-galactosidase. We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase. Read More

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http://dx.doi.org/10.1038/s41401-020-0432-4DOI Listing

Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics.

Acta Pharmacol Sin 2020 May 25. Epub 2020 May 25.

Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.

The advent of immunotherapy is a game changer in cancer therapy with monoclonal antibody- and T cell-based therapeutics being the current flagships. Small molecule immunotherapeutics might offer advantages over the biological drugs in terms of complexity, tissue penetration, manufacturing cost, stability, and shelf life. However, small molecule drugs are prone to rapid systemic distribution, which might induce severe off-target side effects. Read More

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http://dx.doi.org/10.1038/s41401-020-0425-3DOI Listing

The discovery of the lymphatic system in the seventeenth century. Part VI: The microscopic discovery of the subtle anatomy.

Acta Chir Belg 2020 May 26:1-14. Epub 2020 May 26.

Department of Cardiovascular Sciences, Research group of Vascular Surgery, KU Leuven, Leuven, Belgium.

The discovery of chyle and lymph vessels had furthered the dream of understanding the body's structure and functions. Initially it was thought that chyle was sucked from the intestines through the open mouths of chyle vessels, and that lymph vessels were side branches of arterial end branches. In the second half of the 17 century, microscopy became an adjuvant for research into the subtle anatomy of the lymphatic system. Read More

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Prospective Comparison of Intraoperative Touch Imprint Cytology and Frozen Section Histology on Axillary Sentinel Lymph Nodes in Early Breast Cancer Patients.

Acta Cytol 2020 May 25:1-6. Epub 2020 May 25.

Department of Pathology, Tajimi City Hospital, Tajimi, Japan.

Introduction: Since the late 1970s, sentinel lymph node biopsy (SLNB) has been used for several solid malignancies to identify lymph node metastases. This procedure is associated with less surgical morbidity than complete lymphadenectomy. Recent evidence suggests that axillary lymphadenectomy is not required for breast sentinel nodes with micrometastases (≤2 mm). Read More

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http://dx.doi.org/10.1159/000508016DOI Listing

Highly selective rapid colorimetric sensing of Pb ion in water samples and paint based on metal induced aggregation of N-decanoyltromethamine capped gold nanoparticles.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 15;239:118485. Epub 2020 May 15.

Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613 401, Tamil Nadu, India. Electronic address:

Lead is highly toxic. The detection of lead in the environmental bodies is difficult, because it is colourless and odourless. Herein, we report the synthesis of gold nanoparticles (AuNPs) using the interdigitized vesicles formed by N-decanoyltromethamine (NDTM). Read More

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http://dx.doi.org/10.1016/j.saa.2020.118485DOI Listing

One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 14;239:118474. Epub 2020 May 14.

Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Asenapine maleate was approved by the FDA for the treatment of schizophrenia and mania or mixed episodes with bipolar I disorder. In the present article, two spectroscopic methods were developed and validated for the determination of asenapine. Both methods depend on association complex formation between xanthine based dye (eosin Y) and the cited drug in acetate buffer pH = 3. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118474DOI Listing

Absorption and fluorescence properties of non-symmetric benzo-, furo-, and thieno-fused structures at the b bonds in the BODIPY frame.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 13;239:118472. Epub 2020 May 13.

AE Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky st., 664033 Irkutsk, Russia.

The influence of furo-, thieno-, and benzo-fused structures at the b bonds in the BODIPY frame on the optical properties is investigated by TD-CAM-B3LYP and RI-CC2 calculations. The most important result is that substituents at the b bond of the BODIPY core affect strongly the S-S gaps. In contrast to the S (local excited (LE-type)) state, energy of which is nearly the same for all the substituents at the b bond, energy of the S (charge transfer (CT-type)) state depends strongly on the nature of the substituent and decreases in the following order: furo-fused > thieno-fused > benzo-fused. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118472DOI Listing

A natural cyanobacterial protein C-phycoerythrin as an HS selective optical probe in aqueous systems.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 12;239:118469. Epub 2020 May 12.

Applied Phycology and Biotechnology Division, CSIR - Central Salt and Marine Chemicals Research Institute, Gijubhai Badheka Marg, Bhavnagar 364002, Gujarat, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India. Electronic address:

A naturally fluorescent cyanobacterial protein C-phycoerythrin (CPE) was investigated as a fluorescent probe for biologically and environmentally important hydrosulphide (HS) ion. It was selective for HS amongst a large anion screen and the optical response was rapid. Sequential UV-visible titration showed considerable peak shift and attenuation with increasing [HS] while fluorescence titration proved that HS quenched CPE fluorescence in a concentration dependent manner. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118469DOI Listing

Green synthesis of fluorescent N,S-carbon dots from bamboo leaf and the interaction with nitrophenol compounds.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 12;239:118462. Epub 2020 May 12.

Exposure and Biomonitoring Division, Health Canada, 50 Colombine Driveway, Ottawa K1A 0K9, Canada. Electronic address:

A simple and green approach for the synthesis of photoluminescent N,S-carbon dots (N,S-CDs) has been proposed using a single natural source precursor (bamboo leaf) as raw materials. The as-synthesized N,S-CDs exhibited a highly stable, excitation wavelength-dependent emission, excellent photobleaching, alkali, and salt tolerance. Here, the mechanism of N,S-CDs luminescence was studied via the UV-vis absorption spectrum and photoluminescence spectroscopy. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118462DOI Listing

Chromogenic detection of hydrogen sulfide using squarylium-based chemosensors.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 8;239:118457. Epub 2020 May 8.

Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Republic of Korea. Electronic address:

Squarylium-based colorimetric hydrogen sulfide (HS) chemosensors (SQ1, SQ2, and SQ3) were developed, and their detection properties were systematically characterized. SQ1 exhibited rapid and high resolution HS sensing properties through significant color changes detectable by naked-eye with limit of detection as low as 7.2 ppb. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118457DOI Listing

Strategy for optical data encryption and decryption using a D-A type stimuli-responsive AIE material.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 14;239:118486. Epub 2020 May 14.

Department of Chemistry, Capital Normal University, Beijing 100048, China. Electronic address:

In this study, we report a new donor-acceptor (D-A) type stimuli-responsive material, (E)-4-(((9-ethyl-9H-carbazol-2-yl)methylene)amino)benzoic acid (C1), which possesses both aggregation-induced emission (AIE) and intramolecular charge transfer (ICT) natures. It glows green photoluminescence which changes into yellow color in response to mechanical stimuli, and fumigation in volatile organic compounds (VOCs) can switch the emission back to the initial state with high reversibility. In addition, the C1 film glows yellow-orange light, but turns into blue emission under continuous fumigation in ethyl acetate vapor. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118486DOI Listing

Control of neuronal excitability by GSK-3beta: epilepsy and beyond.

Authors:
Tomasz Jaworski

Biochim Biophys Acta Mol Cell Res 2020 May 22:118745. Epub 2020 May 22.

Laboratory of Animal Models, Nencki Institute of Experimental Biology, Warsaw, Poland. Electronic address:

Glycogen synthase kinase 3beta (GSK-3β) is an enzyme with a variety of cellular functions in addition to the regulation of glycogen metabolism. In the central nervous system, different intracellular signaling pathways converge on GSK-3β through a cascade of phosphorylation events that ultimately control a broad range of neuronal functions in the development and adulthood. In mice, genetically removing or increasing GSK-3β cause distinct functional and structural neuronal phenotypes and consequently affect cognition. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118745DOI Listing

Cap-independent translation initiation of the unspliced RNA of retroviruses.

Biochim Biophys Acta Gene Regul Mech 2020 May 22:194583. Epub 2020 May 22.

Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, Santiago, Chile. Electronic address:

Retroviruses are a unique family of RNA viruses that utilize a virally encoded reverse transcriptase (RT) to replicate their genomic RNA (gRNA) through a proviral DNA intermediate. The provirus is permanently integrated into the host cell chromosome and is expressed by the host cell transcription, RNA processing, and translation machinery. Retroviral messenger RNAs (mRNAs) entirely resemble a cellular mRNA as they have a 5'cap structure, 5'untranslated region (UTR), an open reading frame (ORF), 3'UTR, and a 3'poly(A) tail. Read More

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http://dx.doi.org/10.1016/j.bbagrm.2020.194583DOI Listing

Type IV collagen conforms to the organization of polylaminin adsorbed on planar substrata.

Acta Biomater 2020 May 22. Epub 2020 May 22.

ICREA and Institute for Bioengineering of Catalonia (IBEC) Barcelona, Spain. Electronic address:

Tissue engineering demands the development of scaffolds that mimic natural extracellular matrices (ECM). Despite the success in obtaining synthetic interstitial ECM, the production of an artificial basement membrane (BM), the specialized thin sheet of ECM that is pivotal for the functional organization of most tissues and internal organs, is still not achieved. With the long-term aim of developing a flat BM-like structure here we investigated the behavior of acid-soluble Col IV during simultaneous assembly with laminin (LM) in acidic conditions. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.021DOI Listing

Amifostine-loaded armored dissolving microneedles for long-term prevention of ionizing radiation-induced injury.

Acta Biomater 2020 May 22. Epub 2020 May 22.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China. Electronic address:

Amifostine is a cytoprotective agent against the hematopoietic damage induced by ionizing radiation, although the intravenous injection of amifostine is a unique administration method with strict dosing time limitation. Hence, the fields of application of amifostine are greatly limited. Here, we have developed an amifostine-loaded armored microneedle (AAMN) with long-term prevention of hematopoietic injury induced by ionizing radiation. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.025DOI Listing

Continuous microfluidic encapsulation of single mesenchymal stem cells using alginate microgels as injectable fillers for bone regeneration.

Acta Biomater 2020 May 22. Epub 2020 May 22.

State key laboratory of fine chemicals, School of Bioengineering, Dalian University of Technology, Dalian 116023, P. R. China. Electronic address:

The encapsulation of cells in microscale hydrogels can provide a mimic of a three-dimensional (3D) microenvironment to support cell viability and functions and to protect cells from the environmental stress, which have been widely used in tissue regeneration and cell therapies. Here, a microfluidics-based approach is developed for continuous encapsulation of mesenchymal stem cells (MSCs) at the single-cell level using alginate microgels. This microfluidic technique integrated on-chip encapsulation, gelation, and de-emulsification into a one-step fabrication process, which enables scalable cell encapsulation while retaining the viability and functionality of loaded cells. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.024DOI Listing

Utility of d-serine monitoring in kidney disease.

Biochim Biophys Acta Proteins Proteom 2020 May 22:140449. Epub 2020 May 22.

Department of Nephrology, Osaka University Graduate School of Medicine, Japan.

d-Serine, a long-term undetected enantiomer of serine, is now showing its potential as a biomarker for kidney diseases. The intra-body dynamics of d-serine, currently defined by blood levels and urinary excretion dynamics, are useful for a comprehensive assessment of kidney function and disease activity. Thus, widespread adoption of d-serine as a biomarker can resolve the long-standing clinical challenge of the early detection and prognostic prediction of kidney diseases. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140449DOI Listing

Central residues of the amphipathic β-hairpin loop control the properties of Clostridium perfringens epsilon-toxin channel.

Biochim Biophys Acta Biomembr 2020 May 22:183364. Epub 2020 May 22.

Institut Pasteur, Bacterial Toxins, 28 rue du Dr Roux, 75724 Paris cedex 15, France. Electronic address:

Clostridium perfringens epsilon toxin (ETX) is a heptameric pore-forming toxin of the aerolysin toxin family. ETX is the most potent toxin of this toxin family and the third most potent bacterial toxin with high cytotoxic and lethal activities in animals. In addition, ETX shows a demyelinating activity in nervous tissue leading to devastating multifocal central nervous system white matter disease in ruminant animals. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183364DOI Listing
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