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    1723 results match your criteria Acta diabetologica[Journal]

    1 OF 35

    Erratum to: Microvascular effects of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled trials.
    Acta Diabetol 2017 Sep 19. Epub 2017 Sep 19.
    Diabetology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Via delle Oblate 4, 50141, Florence, Italy.
    In the manuscript, the events of nephropathy and retinopathy recorded for the LEADER trial (Marso et al. 2016) were erroneously imputed; the numbers reported in Table 1 for that trial refer to serious adverse events, and not to total events, as stated in Methods. The correct figures are 268 and 416 cases of nephropathy, and 106 and 92 cases of retinopathy in liraglutide and control arms, respectively. Read More

    Decreased plasma neuregulin 4 concentration is associated with increased high-sensitivity C-reactive protein in newly diagnosed type 2 diabetes mellitus patients: a cross-sectional study.
    Acta Diabetol 2017 Sep 16. Epub 2017 Sep 16.
    Department of General Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
    Aims: Inflammation has been reported to be involved in the pathogenesis of atherosclerosis. This principal objective of this study was to investigate if the secretion of neuregulin 4 (Nrg4), a soluble protein associated with metabolic syndrome and subclinical cardiovascular disease, is correlated with the inflammation marker high-sensitivity C-reactive protein (hs-CRP) in patients with newly diagnosed type 2 diabetes mellitus (nT2DM).

    Methods: A study group of 311 nT2DM patients was divided into three subgroups based on hs-CRP tertiles. Read More

    Development of a new scoring system to predict 5-year incident diabetes risk in middle-aged and older Chinese.
    Acta Diabetol 2017 Sep 16. Epub 2017 Sep 16.
    Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd., Wuhan, 430030, Hubei, China.
    Aims: The aim of this study was to develop a new risk score system to predict 5-year incident diabetes risk among middle-aged and older Chinese population.

    Methods: This prospective study included 17,690 individuals derived from the Dongfeng-Tongji cohort. Participants were recruited in 2008 and were followed until October 2013. Read More

    Does diabetes mellitus comorbidity affect in-hospital mortality and length of stay? Analysis of administrative data in an Italian Academic Hospital.
    Acta Diabetol 2017 Sep 15. Epub 2017 Sep 15.
    Endocrinology, Diabetes, Metabolism and Clinical Nutrition, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.
    Aims: Hospitalized patients with comorbid diabetes mellitus may have worse outcomes than the others. We conducted a study to assess whether comorbid diabetes affects in-hospital mortality and length of stay.

    Methods: For this population-based study, we analyzed the administrative databases of the Regional Health Information System of the Region Friuli Venezia Giulia, where the Hospital of Udine is located. Read More

    Unhealthy lifestyle habits and diabetes-specific health-related quality of life in youths with type 1 diabetes.
    Acta Diabetol 2017 Sep 15. Epub 2017 Sep 15.
    Department of Movement Sciences and Wellbeing, University of Naples Parthenope, via Medina 40, 80133, Naples, Italy.
    Aims: Management of type 1 diabetes mellitus (T1DM) influences several aspects of life, such as adherence to healthy lifestyle habits and health-related quality of life (HRQoL). Our aim was to evaluate the association between unhealthy lifestyle habits and HRQoL in adolescents and young adults with T1DM.

    Methods: Two hundred and forty-two Caucasian patients (13-19 years) consecutively enrolled over a 12-month period in three Regional Pediatric Diabetes Centers in Italy. Read More

    Decreased serum extracellular superoxide dismutase activity is associated with albuminuria in Chinese patients with type 2 diabetes mellitus.
    Acta Diabetol 2017 Sep 12. Epub 2017 Sep 12.
    Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, 241001, Anhui, China.
    Aims: The aim of this study was to determine the activity of serum extracellular superoxide dismutase (ecSOD) in patients with type 2 diabetes mellitus (T2DM) and healthy subjects, and to determine the prospective association between baseline serum ecSOD activity and the subsequent risk of albuminuria progression in a cohort of Chinese T2DM patients.

    Methods: A total of 458 T2DM patients and 100 healthy subjects were assessed. After a median follow-up of 7. Read More

    Species differences in pancreatic binding of DO3A-VS-Cys(40)-Exendin4.
    Acta Diabetol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, SE-751 83, Uppsala, Sweden.
    Aims: Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were observed.

    Methods: In vitro and ex vivo autoradiography studies of pancreas were performed using [(177)Lu]Lu-DO3A-VS-Cys(40)-Exendin4, in order to investigate the mechanism of uptake as well as the islet uptake contrast in mouse, rat, pig, and non-human primate. Read More

    Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin.
    Acta Diabetol 2017 Sep 2. Epub 2017 Sep 2.
    Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.
    Aims: Inverse relationships have been described between the largely genetically determined levels of serum/plasma lipoprotein(a) [Lp(a)], type 2 diabetes (T2D) and fasting insulin. Here, we aimed to evaluate the nature of these relationships with respect to causality.

    Methods: We tested whether we could replicate the recent negative findings on causality between Lp(a) and T2D by employing the Mendelian randomization (MR) approach using cross-sectional data from three independent cohorts, Berlin Aging Study II (BASE-II; n = 2012), LIFE-Adult (n = 3281) and LIFE-Heart (n = 2816). Read More

    Enteroviruses in blood of patients with type 1 diabetes detected by integrated cell culture and reverse transcription quantitative real-time PCR.
    Acta Diabetol 2017 Aug 31. Epub 2017 Aug 31.
    Laboratoire de Virologie EA3610, Univ Lille, Faculté de Médecine, CHU Lille, 59000, Lille, France.
    Aims: Enteroviruses (EV) have been associated with type 1 diabetes (T1D), but EV RNA detection has been reported in only a small proportion of T1D patients. We studied whether integrated cell culture and reverse transcription real-time PCR could improve EV detection in blood samples from patients with T1D.

    Methods: Blood was collected from 13 patients with T1D. Read More

    Retinal thickness as a marker of disease progression in longitudinal observation of patients with Wolfram syndrome.
    Acta Diabetol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Sporna Str. 36/50, 91-738, Lodz, Poland.
    Aims: Wolfram syndrome (WFS) is a recessively inherited monogenic form of diabetes coexisting with optic atrophy and neurodegenerative disorders with no currently recognized markers of disease progression. The aim of the study was to evaluate retinal parameters by using optical coherence tomography (OCT) in WFS patients after 2 years of follow-up and analysis of the parameters in relation to visual acuity.

    Methods: OCT parameters and visual acuity were measured in 12 WFS patients and 31 individuals with type 1 diabetes. Read More

    Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study.
    Acta Diabetol 2017 Aug 30. Epub 2017 Aug 30.
    Institute of Diabetes Research, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
    Aims: The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical models. Read More

    Self-care, quality of life and clinical outcomes of type 2 diabetes patients: an observational cross-sectional study.
    Acta Diabetol 2017 Aug 29. Epub 2017 Aug 29.
    Unit of Endocrinology, Diabetology and Metabolic Diseases, IRCCS MultiMedica, Sesto San Giovanni, Italy.
    Aims: To describe self-care of T2DM patients and to evaluate outcomes associated with self-care in T2DM patients.

    Methods: A multicentre cross-sectional study was conducted on a sample of 302 randomly selected T2DM patients. Clinical and socio-demographic data were collected by medical records. Read More

    Clinical characteristics and risk factors for retinal diabetic neurodegeneration in type 2 diabetes.
    Acta Diabetol 2017 Aug 24. Epub 2017 Aug 24.
    Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University Hospital, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea.
    Aims: To identify clinical characteristics and risk factors of retinal neurodegeneration represented by macular ganglion cell/inner plexiform layer (mGCIPL) thinning in patients with long-standing type 2 diabetes mellitus (T2DM).

    Methods: Patients who had T2DM for >15 years were prospectively recruited from September 2014 to July 2015. Clinical data and samples were collected according to the Common Data Element and Standards of Procedure developed by the Korean Diabetes Association research council. Read More

    Physical activity and change in fasting glucose and HbA1c: a quantitative meta-analysis of randomized trials.
    Acta Diabetol 2017 Aug 24. Epub 2017 Aug 24.
    Strathclyde Institute of Global Public Health at iPRI, Espace Européen d'Ecully, Bâtiment G, Allée Claude Debussy, 69130, Ecully Ouest Lyon, France.
    Aims: A systematic review was conducted of randomized trials which evaluated the impact of physical activity on the change in fasting glucose and HbA1c.

    Methods: A literature search was conducted in PubMed until December 2015. Studies reporting glucose or HbA1c at baseline and at the end of study were included, and the change and its variance were estimated from studies with complete data. Read More

    Hyperglycemia induces attention and gait deficits in diabetic mellitus patients.
    Acta Diabetol 2017 Aug 23. Epub 2017 Aug 23.
    Department of Internal Medicine, Cliniques Universitaires Erasme (ULB), 808 Route de Lennik, 1070, Brussels, Belgium.
    Aims: Patients with diabetes mellitus experience a large number of falls and bone fractures that are not related solely to complications of the disease. The purpose of our study was to determine whether transient hyperglycemia affects attentional functions and gait.

    Methods: This was a case-control study. Read More

    Circulating IL-8 levels are increased in patients with type 2 diabetes and associated with worse inflammatory and cardiometabolic profile.
    Acta Diabetol 2017 Aug 23. Epub 2017 Aug 23.
    Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
    Aims: Interleukin-8 (IL-8) is a chemokine involved in systemic immunity, macrophages infiltration and activation in adipose tissue and may play a significant role in the pathogenesis of type 2 diabetes (T2D) and atherosclerosis. Aims of this study were to evaluate circulating IL-8 levels in adult patients with T2D in comparison with non-diabetic subjects and to describe clinical and biochemical correlates of IL-8 concentration.

    Methods: For this cross-sectional study, we enrolled 79 consecutive T2D individuals referring to our diabetes outpatient clinics at Sapienza University of Rome, and 37 sex, age and BMI comparable non-diabetic subjects as a control group. Read More

    Metformin attenuates the TLR4 inflammatory pathway in skeletal muscle of diabetic rats.
    Acta Diabetol 2017 Aug 9. Epub 2017 Aug 9.
    Institute of Genetics and Biochemistry (INGEB), Federal University of Uberlandia, Rua Acre, S/N, Bloco 2E, Sala 237, Campus Umuruama, Uberlândia, MG, CEP 38400-902, Brazil.
    Aims: Inflammation induced by hyperglycemia triggers the toll-like receptor (TLR) pathway into cells. Our hypothesis was that metformin treatment attenuates the TLR signaling pathways triggered by inflammation in skeletal muscle of hypoinsulinemic/hyperglycemic STZ-induced rats. Thus, we examined TLR signaling under hypoinsulinemia and hyperglycemia conditions and its correlation with insulin resistance in muscle of diabetic rats treated with metformin. Read More

    Erratum to: HBV and HCV infection in type 2 diabetes mellitus: a survey in three diabetes units in different Italian areas.
    Acta Diabetol 2017 Sep;54(9):887
    Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, 40138, Bologna, Italy.

    Microvascular effects of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled trials.
    Acta Diabetol 2017 Jul 27. Epub 2017 Jul 27.
    Diabetology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Via delle Oblate 4, 50141, Florence, Italy.
    Aims: Results with GLP1-receptor agonists (GLP-1RA) on microvascular complications of diabetes are contrasting. In trials designed for cardiovascular outcomes, both liraglutide and semaglutide were associated with a relevant reduction in the incidence and progression of nephropathy. On the other hand, in the same trials, semaglutide was associated with an increased progression of retinopathy, and a similar trend was observed for liraglutide. Read More

    Anemia: an independent risk factor of diabetic peripheral neuropathy in type 2 diabetic patients.
    Acta Diabetol 2017 Jul 21. Epub 2017 Jul 21.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road No. 1, Yuzhong District, Chongqing, 400016, China.
    Aims: Recently, the association between anemia and diabetic microvascular complications has been studied. Diabetic peripheral neuropathy (DPN) is also a common complication of type 2 diabetes mellitus (T2DM), while the relationship between anemia and DPN is rarely investigated. The aim of this study is to evaluate the association between anemia and DPN in T2DM. Read More


    Glucokinase mutations in pediatric patients with impaired fasting glucose.
    Acta Diabetol 2017 Jul 19. Epub 2017 Jul 19.
    Pediatric Clinic, Regional Center of Diabetes, Istituto Giannina Gaslini, Via G. Gaslini, 5, 16147, Genoa, Italy.
    Aims: Our aim was to detect the frequency of glucokinase (GCK) gene mutations in a cohort of patients with impaired fasting glucose and to describe the clinical manifestations of identified variants. We also aimed at predicting the effect of the novel missense mutations by computational approach.

    Methods: Overall 100 unrelated Italian families with impaired fasting glucose were enrolled and subdivided into two cohorts according to strict and to mild criteria for diagnosis of maturity-onset diabetes of the young (MODY). Read More

    The ZJU index is a powerful index for identifying NAFLD in the general Chinese population.
    Acta Diabetol 2017 Jul 12. Epub 2017 Jul 12.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
    Aims: The ZJU index is a novel model for detecting non-alcoholic fatty liver disease (NAFLD) that it is calculated based on combination of the body mass index, fasting plasma glucose, triglycerides, and the serum alanine aminotransferase-to-aspartate transaminase ratio. We aimed to evaluate the diagnostic accuracy of the ZJU index in detecting NAFLD in the Chinese population.

    Methods: This was a cross-sectional study. Read More

    Aquatic exercise for adults with type 2 diabetes: a meta-analysis.
    Acta Diabetol 2017 Jul 10. Epub 2017 Jul 10.
    Faculty of Physical Education and Recreation, 1-052 Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
    Aims: The purpose of this systematic review and meta-analysis was to examine the effects of aquatic exercise (AquaEx) on indicators of glycemic control (i.e., glycated hemoglobin [A1c] and fasting plasma glucose) in adults with type 2 diabetes mellitus (T2DM). Read More

    Epicardial adipose tissue: at the heart of the obesity complications.
    Acta Diabetol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Systems Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133, Rome, Italy.
    In recent years, the anatomic and functional contiguity of epicardial adipose tissue (EAT) to myocardium and coronary arteries has gained increasing interest for its potential pathogenetic role in obesity-related cardiac diseases. Besides its known and attributed biochemical cardioprotective properties, it is becoming evident that, in metabolic disease states, EAT-secreted bioactive molecules may play an important role in the pathogenesis of coronary artery disease and cardiac arrhythmias. EAT-derived inflammatory cytokines and reactive oxidative species may, indeed, play a part in the development of a local proatherogenic milieu by paracrine and vasocrine mechanisms of interaction. Read More

    Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease.
    Acta Diabetol 2017 Jun 21. Epub 2017 Jun 21.
    Pediatric Clinic, Insubria University, Varese, Italy.
    Aims: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes. Read More

    Incidence of prolonged QTc and severe hypoglycemia in type 1 diabetes: the EURODIAB Prospective Complications Study.
    Acta Diabetol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
    Aims: To assess the independent role of severe hypoglycemia on 7-year cumulative incidence of prolonged QTc in a large cohort of patients with type 1 diabetes.

    Methods: People with type 1 diabetes recruited by the EURODIAB Prospective Complications Study who had normal QTc were examined at baseline and after 7 years with standardized methods (n = 1415; mean age ± SD 32.1 ± 9. Read More

    Diabetes mellitus: a risk factor for seizures in the elderly-a population-based study.
    Acta Diabetol 2017 Jun 19. Epub 2017 Jun 19.
    Laboratory of Neurological Disorders, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
    Aims: To evaluate the association between diabetes mellitus (DM) and risk of seizures in a well-defined elderly population.

    Methods: The administrative databases of the Lombardy region (a 10 million population area in Northern Italy) were used to identify persons aged 65 years or older with DM (defined by prescription of antidiabetic drugs and/or through ICD-9 CM code and/or exemption code for diabetes) during the year 2002. Seizure-free DM subjects were followed until 2012 in search of individuals with incident seizures (identified through ICD-9 CM codes for epilepsy/seizures or ATC codes for antiepileptic drugs associated with the prescription of an electroencephalogram). Read More

    Improving diabetes care at primary care level with a multistrategic approach: results of the DIAPREM programme.
    Acta Diabetol 2017 Jun 17. Epub 2017 Jun 17.
    CENEXA Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET), Facultad de Ciencias Médicas (UNLP), 60 y 120, 1900, La Plata, Argentina.
    Aim: To present results, 1 year postimplementation at primary care level, of an integrated diabetes care programme including systemic changes, education, registry (clinical, metabolic, and therapeutic indicators), and disease management (DIAPREM).

    Methods: We randomly selected and trained 15 physicians and 15 nurses from primary care units of La Matanza County (intervention-IG) and another 15 physicians/nurses to participate as controls (control-CG). Each physician-nurse team controlled and followed up 10 patients with type 2 diabetes for 1 year; both groups used structured medical records. Read More

    Effect of lifestyle improvement program on the biomarkers of adiposity, inflammation and gut hormones in overweight/obese Asian Indians with prediabetes.
    Acta Diabetol 2017 Jun 15. Epub 2017 Jun 15.
    Department of Research Biochemistry, Madras Diabetes Research Foundation (MDRF), 4, Conran Smith Road, Gopalapuram, Chennai, 600 086, India.
    Aims: While lifestyle modification is known to offer several metabolic benefits, there is paucity of comprehensive data on changes in biomarkers of adiposity, inflammation as well as gut hormones. We investigated these biomarkers in overweight/obese individuals with prediabetes randomized to either 4 months of a lifestyle improvement program or standard care and followed them up for a year.

    Methods: Participants [standard care and intervention arm (n = 75 each)] were randomly selected from the Diabetes Community Lifestyle Improvement Program trial. Read More

    Poly(ADP-ribosylated) proteins in mononuclear cells from patients with type 2 diabetes identified by proteomic studies.
    Acta Diabetol 2017 Jun 12. Epub 2017 Jun 12.
    Departments of Biochemical Sciences and of Experimental Medicine, Sapienza University of Roma, Rome, Italy.
    Aims: In diabetes, hyperglycemia increases reactive oxygen species that induce DNA damage and poly(ADP-ribose)polymerase activation. The aim of this study is to characterize the proteomic profile and the role of poly(ADP-ribosylation) in patients with type 2 diabetes.

    Methods: A proteomic platform based on 2DE and MALDI-ToF spectrometry was applied to peripheral blood mononuclear cells obtained from two different cohorts in which diabetic (n = 14) and normoglycemic patients (n = 11) were enrolled. Read More

    Relationship between hyperbaric oxygen therapy and quality of life in participants with chronic diabetic foot ulcers: data from a randomized controlled trial.
    Acta Diabetol 2017 Jun 12. Epub 2017 Jun 12.
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
    Aims: To investigate the effect of hyperbaric oxygen therapy on health-related quality of life (HRQoL) in participants with diabetes and chronic foot ulcers.

    Methods: Using data from a randomized controlled trial, we included 103 participants (49 in hyperbaric oxygen therapy group and 54 in sham group) for analyses. The primary outcome was HRQoL as measured by the EQ-5D-3L instrument, while secondary outcomes included quality of life evaluated by the Short Form 36 (SF-36) and Diabetic Foot Ulcers Scale-Short Form (DFS-SF). Read More

    Psychological outcomes of injection port therapy in children and adolescents with type 1 diabetes and their primary caregivers.
    Acta Diabetol 2017 Jun 8. Epub 2017 Jun 8.
    Department of the Woman, of the Child and of the General and Specialistic Surgery, University of Campania "Luigi Vanvitelli", Regional Centre of Paediatric Diabetology "G.Stoppoloni", Via Luigi De Crecchio, 2, Naples, Italy.

    GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus.
    Acta Diabetol 2017 Jun 9. Epub 2017 Jun 9.
    Endocrine Division, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, Prédio 12, 4º andar, Zip Code: 90035-003, Porto Alegre, Rio Grande do Sul, Brazil.
    Aims: The transcription factor Gli-similar 3 (GLIS3) plays a key role in the development and maintenance of pancreatic beta cells as well as in the regulation of Insulin gene expression in adults. Accordingly, genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 diabetes mellitus (T1DM) and glucose metabolism traits. Therefore, the aim of this study was to replicate the association of the rs10758593 and rs7020673 single nucleotide polymorphisms (SNPs) in the GLIS3 gene with T1DM in a Brazilian population. Read More

    Hepatocyte nuclear factor 1β maturity-onset diabetes of the young in a Chinese child presenting with hyperglycemic hyperosmolar state.
    Acta Diabetol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, 325000, Zhejiang, People's Republic of China.

    Lifestyle-tailored interventions for South Asians with type 2 diabetes living in high-income countries: a systematic review.
    Acta Diabetol 2017 Aug 6;54(8):785-794. Epub 2017 Jun 6.
    Epidemiology Unit, Local Health Authority of Reggio Emilia, Reggio Emilia, Italy.
    Aim: To summarize evidence on the effectiveness of educational interventions for type 2 diabetes control in South Asians living in high-income countries.

    Methods: We systematically searched PubMed, EMBASE, Cinahl and the Cochrane Library, using Medical Subject Heading and free-text terms. The considered outcomes were: mortality, morbidity, glycaemic control, blood pressure, practice (diet, physical activity and self-care), attitudes/awareness and knowledge. Read More

    Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity.
    Acta Diabetol 2017 Aug 2;54(8):775-784. Epub 2017 Jun 2.
    Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
    Aim: It has been suggested that glucose levels ≥155 mg/dl at 1-h during an oral glucose tolerance test (OGTT) may predict development of type 2 diabetes and cardiovascular events among adults with normal glucose tolerance (NGT 1 h-high). Studies showed a link between increased blood viscosity and type 2 diabetes. However, whether blood viscosity is associated with dysglycemic conditions such as NGT 1 h-high, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) is unsettled. Read More

    Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra-widefield fluorescein angiography: a pilot study.
    Acta Diabetol 2017 Aug 2;54(8):769-773. Epub 2017 Jun 2.
    Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina 60, Milan, 20132, Italy.
    Aims: To investigate the effect of dexamethasone intravitreal implant on peripheral ischemia in patients affected by diabetic macular edema (DME).

    Methods: Patients with treatment-naïve diabetic retinopathy (DR) undergoing intravitreal dexamethasone implant for DME between October 2015 and March 2017 were enrolled. Patients underwent a comprehensive ocular examination at baseline (<2 weeks before treatment) and 10 ± 2 weeks after dexamethasone implant including best-corrected visual acuity (BCVA), intraocular pressure, optical coherence tomography, ultra-widefield (UWF) retinography and UWF fluorescein angiography (UWFA). Read More

    Genome-wide gene expression profiling reveals that CD274 is up-regulated new-onset type 1 diabetes mellitus.
    Acta Diabetol 2017 Aug 2;54(8):757-767. Epub 2017 Jun 2.
    Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, China.
    Aims: Early studies have identified type 1 diabetes mellitus (T1DM) as a disease that is caused by the autoimmune destruction of the insulin-producing pancreatic β-cells. Genetics, environment and the immune pathogenesis of T1DM are three major pillars of T1DM research. We try to understand the changes in the gene expression profile during the pathogenesis of T1DM. Read More

    The affective and somatic side of depression: subtypes of depressive symptoms show diametrically opposed associations with glycemic control in people with type 1 diabetes.
    Acta Diabetol 2017 Aug 29;54(8):749-756. Epub 2017 May 29.
    Research Institute of the Diabetes Academy Mergentheim (FIDAM), Johann-Hammer-Str. 24, 97980, Bad Mergentheim, Germany.
    Aims: While depression has been linked to serious adverse outcomes in diabetes, associations with glycemic control are not conclusive. Inconsistencies could be due to the complex symptomatology of depression. Aim of this study was to analyze the associations of depressive subtypes with glycemic control in people with type 1 and type 2 diabetes. Read More

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