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    1745 results match your criteria Acta diabetologica[Journal]

    1 OF 35

    Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial.
    Acta Diabetol 2017 Nov 18. Epub 2017 Nov 18.
    Department of Clinical Medicine and Surgery, "Federico II" University, 5, Sergio Pansini, 80131, Naples, Italy.
    Aims: Due to their different chemical structures and metabolism, polyphenol subclasses may have specific impact on cardiometabolic risk factors. Our aim was to evaluate whether the intake of different polyphenol subclasses is associated with clinical outcomes beneficially improved by polyphenols in a nutritional trial performed by our group (postprandial lipid response, glucose homeostasis, early insulin secretion and oxidative stress).

    Methods: The present study is a secondary analysis of a nutritional intervention study with a diet naturally rich in polyphenols. Read More

    The potential role of the osteopontin-osteocalcin-osteoprotegerin triad in the pathogenesis of prediabetes in humans.
    Acta Diabetol 2017 Nov 18. Epub 2017 Nov 18.
    Department of Medicine, Division of Diabetes, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.
    Aims: To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes.

    Methods: Individuals (n = 43) with NGT (BMI = 31.1 ± 1. Read More

    Substantial improvement in HbA1c following a treatment and teaching programme for people with type 2 diabetes on conventional insulin therapy in an in- and outpatient setting.
    Acta Diabetol 2017 Nov 17. Epub 2017 Nov 17.
    Endocrinology and Metabolic Diseases, Department of Internal Medicine III, Jena University Hospital, Am Klinikum 1, 07740, Jena, Germany.
    Aims: The aim of the study was to assess the efficacy of a patient education programme (DTTP) for the optimisation of conventional insulin therapy in patients with type 2 diabetes in an in- and outpatient setting.

    Methods: The study was designed as a prospective, longitudinal trial. Thirty-three people with diabetes (females 54. Read More

    Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice.
    Acta Diabetol 2017 Nov 13. Epub 2017 Nov 13.
    Laboratorio di Biochimica Analitica e Proteomica, Centro Scienze dell'Invecchiamento e Medicina Traslazionale - CeSI-MeT, Via Luigi Polacchi 11, 66100, Chieti, Italy.
    Aims: The tissue inhibitor of metalloproteinase TIMP3 is a stromal protein that restrains the activity of both protease and receptor in the extracellular matrix and has been found to be down-regulated in diabetic nephropathy (DN), the leading cause of end-stage renal disease in developed countries.

    Methods: In order to gain deeper insights on the association of loss of TIMP3 and DN, we performed differential proteomic analysis of kidney and blood metabolic profiling of wild-type and Timp3-knockout mice before and after streptozotocin (STZ) treatment, widely used to induce insulin deficiency and hyperglycemia.

    Results: Kidney proteomic data and blood metabolic profiles suggest significant alterations of peroxisomal and mitochondrial fatty acids β-oxidation in Timp3-knockout mice compared to wild-type mice under basal condition. Read More

    Health literacy in type 2 diabetes patients: a systematic review of systematic reviews.
    Acta Diabetol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
    Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, and searching on PubMed, CINAHL, Scopus, and Cochrane. The search covered the period between January 2006 and June 2016. Read More

    Fetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis.
    Acta Diabetol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong Island, Hong Kong.
    Aims: Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. Read More

    Routine resting energy expenditure measurement increases effectiveness of dietary intervention in obesity.
    Acta Diabetol 2017 Nov 3. Epub 2017 Nov 3.
    Endocrinology and Metabolism, Policlinico San Donato Hospital and Scientific Institute, Via Morandi 30, 20097, San Donato Milanese, Italy.
    Aims: Primary outcome of this observational study was to compare weight changes in two groups of overweight and obese individuals: subjects who had a diet prescribed on the base of resting energy expenditure (REE) measured by indirect calorimetry and subjects whose REE was estimated by a predictive equation. In addition, we analyzed differences in weight and metabolic parameter variation in subjects with and without an adequate to predicted REE.

    Methods: We retrospectively analyzed data of 355 overweight and obese patients: 215 on a diet based on REE measured by indirect calorimetry and 140 following a diet based on REE estimated by the Harris-Benedict equation. Read More

    Fetal sex influences maternal fasting plasma glucose levels and basal β-cell function in pregnant women with normal glucose tolerance.
    Acta Diabetol 2017 Dec 2;54(12):1131-1138. Epub 2017 Nov 2.
    Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, People's Republic of China.
    Aims: Fetal sex has recently emerged as a new factor that is related to maternal glucose homeostasis during pregnancy. The present study aimed to investigate the effect of fetal sex on maternal glucose metabolism in women with normal glucose tolerance (NGT) during pregnancy in the Chinese population.

    Methods: A total of 877 pregnant women with NGT were recruited at 24-28 weeks of gestation and underwent a 75-g oral glucose tolerance test (OGTT). Read More

    Errors in insulin treatment management and risk of lipohypertrophy.
    Acta Diabetol 2017 Nov 2. Epub 2017 Nov 2.
    Università degli Studi Della Campania: L. Vanvitelli. Corso di Laurea in Infermieristica. ASL CE, via Napoli, 81024, Maddaloni, Italy.
    Aims: Lipohypertrophy (LH) represents the most common skin-related complication associated with insulin therapy. Our aim is to estimate the prevalence of LH among insulin-treated patients, to identify its association with errors in insulin injection technique and storage, and the correlation between LH, risk of hypoglycemia, and glycemic control.

    Methods: Consecutive patients with T1DM or T2DM, attending a diabetes clinic for a routine visit, were administered an anonymous questionnaire investigating the modalities of insulin injection, the correct use of pen device, insulin storage, and reported frequency of hypoglycemic episodes. Read More

    New equations to estimate resting energy expenditure in obese adults from body composition.
    Acta Diabetol 2017 Oct 30. Epub 2017 Oct 30.
    CNR, IBFM UOS of Germaneto, University "Magna Graecia" of Catanzaro, Campus "Salvatore Venuta", 88100, Germaneto, Catanzaro, Italy.
    Aims: The aims of this study were: to develop new equations for predicting resting energy expenditure (REE) in obese Italian subjects according to body composition parameters; to compare them with predicted values estimated by other REE prediction equations; and to cross-validate our equations using a validation set cohort.

    Methods: Four hundred patients were enrolled and divided into three groups. Besides anthropometry and REE (indirect calorimetry), total body fat and lean were evaluated by dual X-ray absorptiometry, and fat mass and fat-free mass by bioelectrical impedance analysis. Read More

    Pancreatic imaging using an antibody fragment targeting the zinc transporter type 8: a direct comparison with radio-iodinated Exendin-4.
    Acta Diabetol 2017 Oct 24. Epub 2017 Oct 24.
    Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.
    Aim: The zinc transporter 8 (ZnT8) has been suggested as a suitable target for non-invasive visualization of the functional pancreatic beta cell mass, due to both its pancreatic beta cell restricted expression and tight involvement in insulin secretion.

    Methods: In order to examine the potential of ZnT8 as a surrogate target for beta cell mass, we performed mRNA transcription analysis in pancreatic compartments. A novel ZnT8 targeting antibody fragment Ab31 was radiolabeled with iodine-125, and evaluated by in vitro autoradiography in insulinoma and pancreas as well as by in vivo biodistribution. Read More

    HLA, infections and inflammation in early stages of atherosclerosis in children with type 1 diabetes.
    Acta Diabetol 2017 Oct 24. Epub 2017 Oct 24.
    Department of Paediatric Cardiology, Paediatric Heart Center, Lund University and Skåne University Hospital, 22185, Lund, Sweden.
    Aims: This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D).

    Methods: Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. Read More

    Implication of decreased serum complement 3 in patients with diabetic nephropathy.
    Acta Diabetol 2017 Oct 17. Epub 2017 Oct 17.
    Division of Nephrology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.
    Aims: The serum complement 3 (C3) level was reduced in many patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). However, the clinical implications of such change are still less understood. This study was aimed to explore the association between C3 level and the baseline clinicopathological characteristics and the prognosis of T2DM patients with DN. Read More

    Arterial-ventricular coupling in type 1 diabetes: arterial stiffness is associated with impaired global longitudinal strain in type 1 diabetes patients-the Thousand & 1 Study.
    Acta Diabetol 2017 Oct 16. Epub 2017 Oct 16.
    Steno Diabetes Center Copenhagen, Niels Steensens Vej 1, 2820, Gentofte, Denmark.
    Aims: Diabetes is associated with higher arterial stiffness-an early marker of cardiovascular disease. The coupling between arterial stiffness and myocardial function is still unresolved. We investigate associations between arterial stiffness and early myocardial impairment assessed with advanced echocardiography. Read More

    Evaluation of the value of plasma concentration of copeptin in the first prenatal visit to diagnose gestational diabetes mellitus.
    Acta Diabetol 2017 Dec 4;54(12):1123-1129. Epub 2017 Oct 4.
    The First Obstetrical Department, Cangzhou Central Hospital, No. 201, Xinhuazhong Street, Cangzhou, 061001, Hebei Province, People's Republic of China.
    Aims: Gestational diabetes mellitus (GDM) is increasing worldwide. The aim of this study was to investigate whether copeptin concentrations, measured at the first prenatal visit, are associated with risk of GDM.

    Methods: From July 2015 to June 2016, consecutive women who admitted to the obstetrics center of our hospital were included. Read More

    Determinants of preeclampsia in women with type 1 diabetes.
    Acta Diabetol 2017 Dec 3;54(12):1115-1121. Epub 2017 Oct 3.
    Division of Reproduction, Department of Obstetrics, Gynecology and Gynecological Oncology, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland.
    Aims: Despite improvement in diabetic care over the years, the incidence of hypertensive disorders of pregnancy is still very high. Therefore, the aim of our study was to determine risk factors for PE in women with T1DM.

    Methods: This study was a prospective, nested case-control study on a population of 165 women with T1DM. Read More

    Predictors of response to glucagon-like peptide-1 receptor agonists: a meta-analysis and systematic review of randomized controlled trials.
    Acta Diabetol 2017 Dec 20;54(12):1101-1114. Epub 2017 Sep 20.
    Diabetology, Careggi Teaching Hospital, Azienda Ospedaliero-Universitaria Careggi, Via delle Oblate 4, 50141, Florence, Italy.
    Aims: The aim of the present meta-analysis is the identification of the characteristics of patients, which predict the efficacy on HbA1c of glucagon-like peptide-1 receptor agonists (GLP-1 RA).

    Methods: A Medline and Embase search for "exenatide" OR "liraglutide" OR "albiglutide" OR "dulaglutide" OR "lixisenatide" was performed, collecting randomized clinical trials (duration > 12 weeks) up to September 2016, comparing GLP-1 RA at the maximal approved dose with placebo or active drugs. Furthermore, unpublished studies were searched in the www. Read More

    Erratum to: Microvascular effects of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled trials.
    Acta Diabetol 2017 Nov;54(11):1069-1071
    Diabetology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Via delle Oblate 4, 50141, Florence, Italy.
    In the manuscript, the events of nephropathy and retinopathy recorded for the LEADER trial (Marso et al. 2016) were erroneously imputed; the numbers reported in Table 1 for that trial refer to serious adverse events, and not to total events, as stated in Methods. The correct figures are 268 and 416 cases of nephropathy, and 106 and 92 cases of retinopathy in liraglutide and control arms, respectively. Read More

    Decreased plasma neuregulin 4 concentration is associated with increased high-sensitivity C-reactive protein in newly diagnosed type 2 diabetes mellitus patients: a cross-sectional study.
    Acta Diabetol 2017 Dec 16;54(12):1091-1099. Epub 2017 Sep 16.
    Department of General Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
    Aims: Inflammation has been reported to be involved in the pathogenesis of atherosclerosis. This principal objective of this study was to investigate if the secretion of neuregulin 4 (Nrg4), a soluble protein associated with metabolic syndrome and subclinical cardiovascular disease, is correlated with the inflammation marker high-sensitivity C-reactive protein (hs-CRP) in patients with newly diagnosed type 2 diabetes mellitus (nT2DM).

    Methods: A study group of 311 nT2DM patients was divided into three subgroups based on hs-CRP tertiles. Read More

    Development of a new scoring system to predict 5-year incident diabetes risk in middle-aged and older Chinese.
    Acta Diabetol 2017 Sep 16. Epub 2017 Sep 16.
    Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd., Wuhan, 430030, Hubei, China.
    Aims: The aim of this study was to develop a new risk score system to predict 5-year incident diabetes risk among middle-aged and older Chinese population.

    Methods: This prospective study included 17,690 individuals derived from the Dongfeng-Tongji cohort. Participants were recruited in 2008 and were followed until October 2013. Read More

    Does diabetes mellitus comorbidity affect in-hospital mortality and length of stay? Analysis of administrative data in an Italian Academic Hospital.
    Acta Diabetol 2017 Dec 15;54(12):1081-1090. Epub 2017 Sep 15.
    Endocrinology, Diabetes, Metabolism and Clinical Nutrition, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.
    Aims: Hospitalized patients with comorbid diabetes mellitus may have worse outcomes than the others. We conducted a study to assess whether comorbid diabetes affects in-hospital mortality and length of stay.

    Methods: For this population-based study, we analyzed the administrative databases of the Regional Health Information System of the Region Friuli Venezia Giulia, where the Hospital of Udine is located. Read More

    Unhealthy lifestyle habits and diabetes-specific health-related quality of life in youths with type 1 diabetes.
    Acta Diabetol 2017 Dec 15;54(12):1073-1080. Epub 2017 Sep 15.
    Department of Movement Sciences and Wellbeing, University of Naples Parthenope, via Medina 40, 80133, Naples, Italy.
    Aims: Management of type 1 diabetes mellitus (T1DM) influences several aspects of life, such as adherence to healthy lifestyle habits and health-related quality of life (HRQoL). Our aim was to evaluate the association between unhealthy lifestyle habits and HRQoL in adolescents and young adults with T1DM.

    Methods: Two hundred and forty-two Caucasian patients (13-19 years) consecutively enrolled over a 12-month period in three Regional Pediatric Diabetes Centers in Italy. Read More

    Decreased serum extracellular superoxide dismutase activity is associated with albuminuria in Chinese patients with type 2 diabetes mellitus.
    Acta Diabetol 2017 Nov 12;54(11):1047-1055. Epub 2017 Sep 12.
    Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, 241001, Anhui, China.
    Aims: The aim of this study was to determine the activity of serum extracellular superoxide dismutase (ecSOD) in patients with type 2 diabetes mellitus (T2DM) and healthy subjects, and to determine the prospective association between baseline serum ecSOD activity and the subsequent risk of albuminuria progression in a cohort of Chinese T2DM patients.

    Methods: A total of 458 T2DM patients and 100 healthy subjects were assessed. After a median follow-up of 7. Read More

    Species differences in pancreatic binding of DO3A-VS-Cys(40)-Exendin4.
    Acta Diabetol 2017 Nov 11;54(11):1039-1045. Epub 2017 Sep 11.
    Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, SE-751 83, Uppsala, Sweden.
    Aims: Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were observed.

    Methods: In vitro and ex vivo autoradiography studies of pancreas were performed using [(177)Lu]Lu-DO3A-VS-Cys(40)-Exendin4, in order to investigate the mechanism of uptake as well as the islet uptake contrast in mouse, rat, pig, and non-human primate. Read More

    Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin.
    Acta Diabetol 2017 Nov 2;54(11):1031-1038. Epub 2017 Sep 2.
    Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany.
    Aims: Inverse relationships have been described between the largely genetically determined levels of serum/plasma lipoprotein(a) [Lp(a)], type 2 diabetes (T2D) and fasting insulin. Here, we aimed to evaluate the nature of these relationships with respect to causality.

    Methods: We tested whether we could replicate the recent negative findings on causality between Lp(a) and T2D by employing the Mendelian randomization (MR) approach using cross-sectional data from three independent cohorts, Berlin Aging Study II (BASE-II; n = 2012), LIFE-Adult (n = 3281) and LIFE-Heart (n = 2816). Read More

    Enteroviruses in blood of patients with type 1 diabetes detected by integrated cell culture and reverse transcription quantitative real-time PCR.
    Acta Diabetol 2017 Nov 31;54(11):1025-1029. Epub 2017 Aug 31.
    Laboratoire de Virologie EA3610, Univ Lille, Faculté de Médecine, CHU Lille, 59000, Lille, France.
    Aims: Enteroviruses (EV) have been associated with type 1 diabetes (T1D), but EV RNA detection has been reported in only a small proportion of T1D patients. We studied whether integrated cell culture and reverse transcription real-time PCR could improve EV detection in blood samples from patients with T1D.

    Methods: Blood was collected from 13 patients with T1D. Read More

    Retinal thickness as a marker of disease progression in longitudinal observation of patients with Wolfram syndrome.
    Acta Diabetol 2017 Nov 30;54(11):1019-1024. Epub 2017 Aug 30.
    Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Sporna Str. 36/50, 91-738, Lodz, Poland.
    Aims: Wolfram syndrome (WFS) is a recessively inherited monogenic form of diabetes coexisting with optic atrophy and neurodegenerative disorders with no currently recognized markers of disease progression. The aim of the study was to evaluate retinal parameters by using optical coherence tomography (OCT) in WFS patients after 2 years of follow-up and analysis of the parameters in relation to visual acuity.

    Methods: OCT parameters and visual acuity were measured in 12 WFS patients and 31 individuals with type 1 diabetes. Read More

    Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study.
    Acta Diabetol 2017 Nov 30;54(11):1009-1017. Epub 2017 Aug 30.
    Institute of Diabetes Research, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
    Aims: The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical models. Read More

    Self-care, quality of life and clinical outcomes of type 2 diabetes patients: an observational cross-sectional study.
    Acta Diabetol 2017 Nov 29;54(11):1001-1008. Epub 2017 Aug 29.
    Unit of Endocrinology, Diabetology and Metabolic Diseases, IRCCS MultiMedica, Sesto San Giovanni, Italy.
    Aims: To describe self-care of T2DM patients and to evaluate outcomes associated with self-care in T2DM patients.

    Methods: A multicentre cross-sectional study was conducted on a sample of 302 randomly selected T2DM patients. Clinical and socio-demographic data were collected by medical records. Read More

    Clinical characteristics and risk factors for retinal diabetic neurodegeneration in type 2 diabetes.
    Acta Diabetol 2017 Nov 24;54(11):993-999. Epub 2017 Aug 24.
    Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University Hospital, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea.
    Aims: To identify clinical characteristics and risk factors of retinal neurodegeneration represented by macular ganglion cell/inner plexiform layer (mGCIPL) thinning in patients with long-standing type 2 diabetes mellitus (T2DM).

    Methods: Patients who had T2DM for >15 years were prospectively recruited from September 2014 to July 2015. Clinical data and samples were collected according to the Common Data Element and Standards of Procedure developed by the Korean Diabetes Association research council. Read More

    Physical activity and change in fasting glucose and HbA1c: a quantitative meta-analysis of randomized trials.
    Acta Diabetol 2017 Nov 24;54(11):983-991. Epub 2017 Aug 24.
    Strathclyde Institute of Global Public Health at iPRI, Espace Européen d'Ecully, Bâtiment G, Allée Claude Debussy, 69130, Ecully Ouest Lyon, France.
    Aims: A systematic review was conducted of randomized trials which evaluated the impact of physical activity on the change in fasting glucose and HbA1c.

    Methods: A literature search was conducted in PubMed until December 2015. Studies reporting glucose or HbA1c at baseline and at the end of study were included, and the change and its variance were estimated from studies with complete data. Read More

    Hyperglycemia induces attention and gait deficits in diabetic mellitus patients.
    Acta Diabetol 2017 Oct 23;54(10):953-959. Epub 2017 Aug 23.
    Department of Internal Medicine, Cliniques Universitaires Erasme (ULB), 808 Route de Lennik, 1070, Brussels, Belgium.
    Aims: Patients with diabetes mellitus experience a large number of falls and bone fractures that are not related solely to complications of the disease. The purpose of our study was to determine whether transient hyperglycemia affects attentional functions and gait.

    Methods: This was a case-control study. Read More

    Circulating IL-8 levels are increased in patients with type 2 diabetes and associated with worse inflammatory and cardiometabolic profile.
    Acta Diabetol 2017 Oct 23;54(10):961-967. Epub 2017 Aug 23.
    Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
    Aims: Interleukin-8 (IL-8) is a chemokine involved in systemic immunity, macrophages infiltration and activation in adipose tissue and may play a significant role in the pathogenesis of type 2 diabetes (T2D) and atherosclerosis. Aims of this study were to evaluate circulating IL-8 levels in adult patients with T2D in comparison with non-diabetic subjects and to describe clinical and biochemical correlates of IL-8 concentration.

    Methods: For this cross-sectional study, we enrolled 79 consecutive T2D individuals referring to our diabetes outpatient clinics at Sapienza University of Rome, and 37 sex, age and BMI comparable non-diabetic subjects as a control group. Read More

    Metformin attenuates the TLR4 inflammatory pathway in skeletal muscle of diabetic rats.
    Acta Diabetol 2017 Oct 9;54(10):943-951. Epub 2017 Aug 9.
    Institute of Genetics and Biochemistry (INGEB), Federal University of Uberlandia, Rua Acre, S/N, Bloco 2E, Sala 237, Campus Umuruama, Uberlândia, MG, CEP 38400-902, Brazil.
    Aims: Inflammation induced by hyperglycemia triggers the toll-like receptor (TLR) pathway into cells. Our hypothesis was that metformin treatment attenuates the TLR signaling pathways triggered by inflammation in skeletal muscle of hypoinsulinemic/hyperglycemic STZ-induced rats. Thus, we examined TLR signaling under hypoinsulinemia and hyperglycemia conditions and its correlation with insulin resistance in muscle of diabetic rats treated with metformin. Read More

    Erratum to: HBV and HCV infection in type 2 diabetes mellitus: a survey in three diabetes units in different Italian areas.
    Acta Diabetol 2017 Sep;54(9):887
    Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, 40138, Bologna, Italy.

    Microvascular effects of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled trials.
    Acta Diabetol 2017 Oct 27;54(10):933-941. Epub 2017 Jul 27.
    Diabetology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Via delle Oblate 4, 50141, Florence, Italy.
    Aims: Results with GLP1-receptor agonists (GLP-1RA) on microvascular complications of diabetes are contrasting. In trials designed for cardiovascular outcomes, both liraglutide and semaglutide were associated with a relevant reduction in the incidence and progression of nephropathy. On the other hand, in the same trials, semaglutide was associated with an increased progression of retinopathy, and a similar trend was observed for liraglutide. Read More

    Anemia: an independent risk factor of diabetic peripheral neuropathy in type 2 diabetic patients.
    Acta Diabetol 2017 Oct 21;54(10):925-931. Epub 2017 Jul 21.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road No. 1, Yuzhong District, Chongqing, 400016, China.
    Aims: Recently, the association between anemia and diabetic microvascular complications has been studied. Diabetic peripheral neuropathy (DPN) is also a common complication of type 2 diabetes mellitus (T2DM), while the relationship between anemia and DPN is rarely investigated. The aim of this study is to evaluate the association between anemia and DPN in T2DM. Read More

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