2,206 results match your criteria Acta diabetologica[Journal]


Correction to: Association of co-accumulation of arsenic and organophosphate insecticides with diabetes and atherosclerosis in a rural agricultural community: KMCH-NNCD-I study.

Acta Diabetol 2020 May 23. Epub 2020 May 23.

DST Unit of Nanoscience and Thematic Unit of Excellence in Water Research, Department of Chemistry, Indian Institute of Technology, Chennai, Tamil Nadu, 600 036, India.

Authors would like to correct the error in the online publication, which is mentioned below. Read More

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http://dx.doi.org/10.1007/s00592-020-01549-xDOI Listing

Long non-coding RNA VIM Antisense RNA 1 (VIM-AS1) sponges microRNA-29 to participate in diabetic retinopathy.

Acta Diabetol 2020 May 23. Epub 2020 May 23.

Department of Ophthalmology, Qingyuan People's Hospital, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan City, 511500, Guangdong Province, People's Republic of China.

Aims: Long non-coding RNA (lncRNA) VIM Antisense RNA 1 (VIM-AS1) has been reported to be correlated with type 2 diabetes (T2D) susceptibility, while the roles of this lncRNA in T2D and its complications remain unclear. This study aimed to explore the role of VIM-AS1 in diabetic retinopathy (DR).

Methods: Gene expression levels in both human specimens and in vitro cultivated cells were determined by qPCR and western blot. Read More

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http://dx.doi.org/10.1007/s00592-020-01536-2DOI Listing

Correction to: Fundamental principles of an effective diabetic retinopathy screening program.

Acta Diabetol 2020 May 18. Epub 2020 May 18.

Department of Ophthalmology Tel Aviv Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Authors would like to correct few errors in their publication which are listed below. Read More

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http://dx.doi.org/10.1007/s00592-020-01541-5DOI Listing

Association between retinol binding protein 4 and diabetic retinopathy among type 2 diabetic patients: a meta-analysis.

Acta Diabetol 2020 May 13. Epub 2020 May 13.

Department of Medical Informatics, Medical School of Nantong University, Nantong, 226001, People's Republic of China.

Aims: The aim of this study was to investigate the association between retinol-binding protein 4 (RBP4) and diabetic retinopathy (DR) among patients with type 2 diabetes mellitus (T2DM).

Methods: Databases PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, VIP, and Wangfang were searched to July 30, 2019. The Newcastle-Ottawa Scale was applied to assess the quality of all identified studies, and those qualified were included in the meta-analysis. Read More

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http://dx.doi.org/10.1007/s00592-020-01535-3DOI Listing

Cataract surgery with combined versus deferred intravitreal dexamethasone implant for diabetic macular edema: long-term outcomes from a real-world setting.

Acta Diabetol 2020 May 4. Epub 2020 May 4.

Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.

Aims: To compare the long-term functional and anatomical outcomes of cataract surgery with combined versus 1-month deferred intravitreal dexamethasone implant (DEX) in eyes with pre-existing diabetic macular edema (DME).

Methods: Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were retrospectively evaluated in both groups before treatments, then 1, 4, 12 and 24 months after DEX.

Results: Forty eyes were analyzed, 20 in each group. Read More

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http://dx.doi.org/10.1007/s00592-020-01509-5DOI Listing

Dipeptidyl peptidase-4 inhibitors and the risks of autoimmune diseases in type 2 diabetes mellitus patients in Taiwan: a nationwide population-based cohort study.

Acta Diabetol 2020 Apr 21. Epub 2020 Apr 21.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Aims: Dipeptidyl peptidase-4, a transmembrane glycoprotein expressed in various cell types, serves as a co-stimulator molecule to influence immune response. This study aimed to investigate associations between DPP-4 inhibitors and risk of autoimmune disorders in patients with type 2 diabetes mellitus in Taiwan.

Methods: This retrospective cohort study used the nationwide data from the diabetes subsection of Taiwan National Health Insurance Research Database between January 1, 2009, and December 31, 2013. Read More

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http://dx.doi.org/10.1007/s00592-020-01533-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173685PMC

Type 1 diabetes and periodontitis: prevalence and periodontal destruction-a systematic review.

Acta Diabetol 2020 Apr 21. Epub 2020 Apr 21.

Diabetes Unit, Careggi Teaching Hospital, Largo Brambilla 3, 50127, Florence, Italy.

Aims: Data about the association between periodontal disease or periodontitis (PD), diabetes and hyperglycemia have been reported mostly in patients with type 2 diabetes. Conversely, information about PD in type 1 diabetes (T1DM) is relatively scarce. The aim of this meta-analysis is therefore: (1) to assess the prevalence and severity of PD in patients affected by T1DM in comparison with the general population and (2) to verify the association between severity of PD and glycemic control in type 1 diabetics. Read More

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http://dx.doi.org/10.1007/s00592-020-01531-7DOI Listing

Association of co-accumulation of arsenic and organophosphate insecticides with diabetes and atherosclerosis in a rural agricultural community: KMCH-NNCD-I study.

Acta Diabetol 2020 Apr 20. Epub 2020 Apr 20.

DST Unit of Nanoscience and Thematic Unit of Excellence in Water Research, Department of Chemistry, Indian Institute of Technology, Chennai, Tamil Nadu, 600 036, India.

Aims: In last few decades, the prevalence of diabetes and vascular diseases has intensified concurrently with increased use of synthetic chemicals in agriculture. This study is aimed to evaluate the association of co-accumulation of arsenic and organophosphate (OP) insecticides with diabetes and atherosclerosis prevalence in a rural Indian population.

Methods: This study included observations from KMCH-NNCD-I (2015) cross-sectional study (n = 865) from an Indian farming village. Read More

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http://dx.doi.org/10.1007/s00592-020-01516-6DOI Listing
April 2020
2.399 Impact Factor

Effects of plant protein and animal protein on lipid profile, body weight and body mass index on patients with hypercholesterolemia: a systematic review and meta-analysis.

Acta Diabetol 2020 Apr 20. Epub 2020 Apr 20.

Endocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, 050051, Hebei, China.

Objective: We conducted a meta-analysis on the effect of plant protein or animal protein on body weight (BW), body mass index (BMI) and blood lipid profiles in patients with hypercholesterolemia.

Materials And Methods: We used subject and free words to search PubMed, Embase and Cochrane Library databases. The risk-of-bias evaluation tool was used to assess literature quality. Read More

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http://dx.doi.org/10.1007/s00592-020-01534-4DOI Listing

The effects of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide 1 receptor agonists on cognitive functions in adults with type 2 diabetes mellitus: a systematic review and meta-analysis.

Acta Diabetol 2020 Apr 16. Epub 2020 Apr 16.

Department of Internal Medicine, Hebei Medical University, Shijiazhuang, 050017, Hebei, People's Republic of China.

Aims: The effects of dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors/DPP-4I) and glucagon-like peptide 1 receptor agonists (GLP-1 RA) on cognition in patients with type 2 diabetes mellitus (T2DM) remain controversial. We aimed to explore this clinical issue through a systematic review and meta-analysis.

Methods: PubMed, EMBASE and the Cochrane Library were searched, and data were expressed as mean difference (MD) or hazard ratio (HR)/odds ratio (OR) with a 95% confidence interval (CI). Read More

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http://dx.doi.org/10.1007/s00592-020-01529-1DOI Listing

Results in comparison between 30 gauge ultrathin wall and 27 gauge needle in sutureless intraocular lens flanged technique in diabetic patients: 24-month follow-up study.

Acta Diabetol 2020 Apr 16. Epub 2020 Apr 16.

Ophthalmology Department, University of Leipzig, Leipzig, Germany.

Aims: Intraoperative complications in cataract surgery are more common in diabetic patients. Solving aphakia in these circumstances remains a challenge, as the scleral structure has been shown to be different in diabetes. This study aims to analyze the role of a secondary sutureless scleral intraocular lens (IOL) flanged fixation in diabetic patients without capsular support and to compare the anatomical and functional outcomes using a 30 gauge (G) ultrathin wall needle vs. Read More

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http://dx.doi.org/10.1007/s00592-020-01530-8DOI Listing

Glycemic emergencies in Albania: glycated hemoglobin as a predictor of length of hospital stay.

Acta Diabetol 2020 Apr 15. Epub 2020 Apr 15.

Catholic University Our Lady of Good Counsel, Tirana, Albania.

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http://dx.doi.org/10.1007/s00592-020-01514-8DOI Listing

Diabetic cardiomyopathy: How can cardiac magnetic resonance help?

Acta Diabetol 2020 Apr 13. Epub 2020 Apr 13.

University of Milan-Bicocca, Milan, Italy.

Diabetes cardiomyopathy is a specific form of cardiac disease characteristic for diabetic patients. Development of echocardiography enabled diagnosis of diabetic cardiomyopathy significantly before the occurrence of heart failure. Previously was believed that left ventricular (LV) diastolic dysfunction represents the first detectable stage of diabetic cardiomyopathy. Read More

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http://dx.doi.org/10.1007/s00592-020-01528-2DOI Listing

TNFR1 is associated with short-term mortality in patients with diabetes and acute dyspnea seeking care at the emergency department.

Acta Diabetol 2020 Apr 12. Epub 2020 Apr 12.

Department of Emergency and Internal Medicine, Skånes University Hospital, Malmö, Sweden.

Background: Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function.

Aim: To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea.

Population And Methods: Patients aged ≥ 18 years seeking at emergency department (ED) during daytime on weekdays between December 2013 and July 2018, with diabetes and acute dyspnea, identified at the triage process, were included. Read More

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http://dx.doi.org/10.1007/s00592-020-01527-3DOI Listing

CXXC4 mediates glucose-induced β-cell proliferation.

Acta Diabetol 2020 Apr 12. Epub 2020 Apr 12.

Department of Endocrinology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou, 350001, Fujian, China.

Aims: CXXC finger protein 4 (CXXC4) is an identified negative regulator of the Wnt/β-catenin pathway, and it is involved in cancer cell proliferation. In this study, we sought to clarify whether CXXC4 is involved in glucose-stimulated β-cell proliferation.

Materials And Methods: We investigated the biological function of CXXC4 in glucose-induced β-cell proliferation, and we investigated the underlying mechanism of this activity. Read More

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http://dx.doi.org/10.1007/s00592-020-01525-5DOI Listing

Associations of food addiction with metabolic control, medical complications and depression among patients with type 2 diabetes.

Acta Diabetol 2020 Apr 10. Epub 2020 Apr 10.

Endocrinology and Nutrition Department, Hospital Son Llàtzer, University Institute of Health Science Research (IUNICS) and Health Research Institute of Balearic Islands (IdISBA), Ctra Manacor km 4, 07198, Palma de Mallorca, Baleares, Spain.

Aims: Food addiction (FA) is conceptualized as a behavioral pattern that is similar in some ways to addictions to alcohol and other substances. This disorder has not been well studied among patients with type 2 diabetes (T2DM). We aimed to analyze if there is any relationship between FA and clinical or psychological variables among patients with T2DM. Read More

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http://dx.doi.org/10.1007/s00592-020-01519-3DOI Listing

Expectations and fears of patients with diabetes and macular edema treated by intravitreal injections.

Acta Diabetol 2020 Apr 9. Epub 2020 Apr 9.

Ophthalmology Department, Hôpital Avicenne and University Paris 13, Bobigny, Paris, France.

Aims: Clinical outcomes of diabetic macular edema (DME) have been widely described, but data on diabetic retinopathy perceptions by diabetes patients are limited. The aim of this survey was to explore the lived experience, knowledge, fears and expectations about disease, and treatment in patients with diabetes and macular edema treated with intravitreal injections (IVTI) and to characterize patient profiles.

Methods: Cross-sectional survey including a preliminary qualitative phase (20 patients with DME, treated or treatment-naive, 5 female and 15 male, age 36-74 years) followed by a quantitative survey (116 patients treated with IVTI for DME). Read More

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http://dx.doi.org/10.1007/s00592-020-01513-9DOI Listing

Lois Jovanovič: a giant in the field of diabetes and pregnancy.

Acta Diabetol 2020 Apr 8. Epub 2020 Apr 8.

Fundación DIABEM, Barcelona, Spain.

Lois Jovanovič (1947-2018) was a trailblazing and relentless clinical endocrinologist and researcher whose innovative approaches to diabetes and pregnancy changed the lives of thousands of women and their babies. Of her many accomplishments, she is best known for devising the diabetes and pregnancy protocols of intensive insulin delivery and glucose control that have made it possible for thousands of women with diabetes to deliver healthy babies and for pioneering the use of insulin analogues in pregnancy. Her research also paved the way for the development of the artificial pancreas. Read More

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http://dx.doi.org/10.1007/s00592-020-01521-9DOI Listing

Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus.

Acta Diabetol 2020 Apr 7. Epub 2020 Apr 7.

Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Whitefield, Bangalore, Karnataka, 560066, India.

Aim: The present study aimed to evaluate the combined effect of both dose and duration of metformin therapy on vitamin B12 levels in patients with type 2 diabetes mellitus (T2D).

Methods: We recruited 2887 patients with T2D between January 2018 and November 2019 and categorized them into two groups (metformin and non-metformin users) matched for age, mean duration of diabetes, and BMI. We calculated the "Metformin Usage Index" (MUI) which was defined as the product of the dose of metformin (mg) used and its duration divided by 1000. Read More

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http://dx.doi.org/10.1007/s00592-020-01526-4DOI Listing

Type 2 diabetes prevalence among Andean immigrants and natives in a Southern European City.

Acta Diabetol 2020 Apr 6. Epub 2020 Apr 6.

Social and Cardiovascular Epidemiology Research Group, School of Medicine, University of Alcala, Alcala de Henares, Madrid, Spain.

Aims: Inequalities in diabetes prevalence among immigrants from Andean countries remain unknown. Andean populations are one of the largest groups of immigrants in Madrid city. We examined the association between country of birth and type 2 diabetes mellitus (T2DM) prevalence in Andean immigrant population relative to Spanish-natives; and whether this association varied by age, sex and length of residence. Read More

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http://dx.doi.org/10.1007/s00592-020-01515-7DOI Listing

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic.

Acta Diabetol 2020 Jun 5;57(6):759-764. Epub 2020 Apr 5.

Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, Italy.

Aims: Analyze the relationship between obesity and influenza.

Methods: Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic. Read More

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http://dx.doi.org/10.1007/s00592-020-01522-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7130453PMC

Comparison and analyses of therapeutic effects between metabolic management center (MMC) and conventional management modes.

Acta Diabetol 2020 Apr 4. Epub 2020 Apr 4.

Beijing Key Laboratory of Diabetes Mellitus Prevention and Research, Department of Endocrinology, Beijing Luhe Hospital, Capital Medical University, 113 Xinhua South Road, Tongzhou District, Beijing City, 101100, China.

Aims: The past 3 decades witnessed the rapid growth of diabetes in China. To better serve large numbers of patients, the Chinese Medical Doctor Association launched metabolic management center (MMC) program which is featured with a one-stop and comprehensive diabetes management mode in 2016. It is worth exploring whether MMC model is better than conventional models in management. Read More

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http://dx.doi.org/10.1007/s00592-020-01518-4DOI Listing

Longitudinal association of type 2 diabetes and insulin therapy with muscle parameters in the KORA-Age study.

Acta Diabetol 2020 Apr 4. Epub 2020 Apr 4.

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

Aims: The aim of the current study was to investigate the association of type 2 diabetes (T2D) and insulin treatment with changes in muscle mass, muscle strength, and physical performance in older adults.

Methods: In 731 participants of the population-based KORA-Age study aged 74.6 ± 6. Read More

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http://dx.doi.org/10.1007/s00592-020-01523-7DOI Listing

Nonmydriatic widefield retinal imaging with an automatic white LED confocal imaging system compared with dilated ophthalmoscopy in screening for diabetic retinopathy.

Acta Diabetol 2020 Apr 3. Epub 2020 Apr 3.

Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute, Via Olgettina 60, Milan, Italy.

Purpose: To compare nonmydriatic montage widefield images with dilated fundus ophthalmoscopy for determining diabetic retinopathy (DR) severity.

Materials And Methods: In this prospective, observational, cross-sectional study, patients with a previous diagnosis of diabetes and without history of diabetes-associated ocular disease were screened for DR. Montage widefield imaging was obtained with a system that combines confocal technology with white-light emitting diode (LED) illumination (DRSplus, Centervue, Padua, Italy). Read More

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http://dx.doi.org/10.1007/s00592-020-01520-wDOI Listing

The impact of educational attainment on the occurrence of gestational diabetes mellitus in two successive pregnancies of Finnish primiparous women: a population-based cohort study.

Acta Diabetol 2020 Apr 2. Epub 2020 Apr 2.

Folkhälsan Research Center, Helsinki, Finland.

Aims: To assess the impact of educational attainment on the occurrence and recurrence of gestational diabetes mellitus (GDM) in two successive pregnancies in primiparous women.

Methods: This is a population-based observational cohort study including all 2347 Finnish women without previously diagnosed diabetes, aged ≥ 20 years from the city of Vantaa, Finland, who gave birth to their first and second child between 2009 and 2015. National registries provided data on study participants. Read More

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http://dx.doi.org/10.1007/s00592-020-01517-5DOI Listing

Fundamental principles of an effective diabetic retinopathy screening program.

Acta Diabetol 2020 Mar 28. Epub 2020 Mar 28.

Department of Ophthalmology Tel Aviv Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Diabetic retinopathy (DR) is the leading cause of blindness among working-age adults worldwide. Early detection and treatment are necessary to forestall vision loss from DR.

Methods: A working group of ophthalmic and diabetes experts was established to develop a consensus on the key principles of an effective DR screening program. Read More

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http://dx.doi.org/10.1007/s00592-020-01506-8DOI Listing
March 2020
2.399 Impact Factor

Darbepoetin-α increases the blood volume flow in transplanted pancreatic islets in mice.

Acta Diabetol 2020 Mar 28. Epub 2020 Mar 28.

Institute for Clinical and Experimental Surgery, Saarland University, 66421, Homburg, Saar, Germany.

Aims: The minimal-invasive transplantation of pancreatic islets is a promising approach to treat diabetes mellitus type 1. However, islet transplantation is still hampered by the insufficient process of graft revascularization, leading to a poor clinical outcome. Accordingly, the identification of novel compounds, which accelerate and improve the revascularization of transplanted islets, is of great clinical interest. Read More

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http://dx.doi.org/10.1007/s00592-020-01512-wDOI Listing

The fellow eye effect of unilateral intravitreal conbercept injections in eyes with diabetic macular edema.

Acta Diabetol 2020 Mar 25. Epub 2020 Mar 25.

Tianjin Medical University Eye Hospital, Tianjin, 300384, China.

Aims: To investigate whether intravitreal conbercept injection affects contralateral untreated eyes in bilateral diabetic macular edema (DME) patients.

Methods: In this retrospective study, 15 patients (30 eyes) with type 2 diabetes were followed after bilateral DME diagnosis in the Department of Ophthalmology, Peking Union Medical College Hospital from 2015 to 2018. Patients underwent examinations including best corrected visual acuity (BCVA), slit-lamp microscopy, indirect ophthalmoscope, color fundus photography, fundus fluorescein angiography, optical coherence tomography, and glycated hemoglobin (HbA1c). Read More

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http://dx.doi.org/10.1007/s00592-020-01511-xDOI Listing

Efficacy and safety of generic exenatide injection in Chinese patients with type 2 diabetes: a multicenter, randomized, controlled, non-inferiority trial.

Acta Diabetol 2020 Mar 23. Epub 2020 Mar 23.

Department of Endocrinology and Metabolism, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, People's Republic of China.

Aims: This study aimed to compare the efficacy and safety of generic exenatide with branded exenatide Byetta in Chinese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on monotherapy or combination therapy of metformin and insulin secretagogues.

Methods: A multicenter, randomized, controlled, non-inferiority trial was performed. A total of 240 patients with T2DM and glycated hemoglobin (HbA1c) ≥ 7% (53 mmol/mol) to ≤ 9. Read More

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http://dx.doi.org/10.1007/s00592-020-01510-yDOI Listing
March 2020
2.399 Impact Factor

Functional correlation between choroidal and retinal vascularity in low-grade diabetic retinopathy.

Acta Diabetol 2020 Mar 23. Epub 2020 Mar 23.

Department of Surgical and Biomedical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, 06156, Perugia, Italy.

Aims: To perform an automated functional assessment of retinal and choroidal microvasculature in eyes with low-grade diabetic retinopathy (DR) using optical coherence tomography angiography (OCT-A) and to identify potential perfusion changes in case of early vascular damage.

Methods: This is an observational, case-control study of consecutive diabetic patients with level 20 DR severity scale score and age-matched healthy subjects. A prototypal OCT-angiography was used to obtain the OCT-angiograms of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) layer. Read More

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http://dx.doi.org/10.1007/s00592-020-01507-7DOI Listing

Changes in corneal biomechanics in patients with diabetes mellitus: a systematic review and meta-analysis.

Acta Diabetol 2020 Mar 22. Epub 2020 Mar 22.

Department of Ophthalmology Center, Huizhou Municipal Central Hospital, Huizhou, Guangdong Province, People's Republic of China.

Aims: To determine the changes in corneal biomechanical parameters in patients with diabetes mellitus (DM) in comparison with controls.

Methods: Pertinent studies were identified by comprehensively search of PubMed, Embase, the Web of Science, the Cochrane Library, Scopus, the China National Knowledge Infrastructure and the Chinese biomedical disc (CBM) databases. Pooling analyses by random models using the D-L method were performed for corneal hysteresis (CH), the corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc) and Goldmann-correlated intraocular pressure (IOPg). Read More

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http://dx.doi.org/10.1007/s00592-020-01481-0DOI Listing

Risk of hypoglycaemia associated with professional, recreational, and traffic-related activities in patients with type 2 diabetes: a cross-sectional study by questionnaire.

Acta Diabetol 2020 Mar 12. Epub 2020 Mar 12.

Diabeteszentrum Bad Lauterberg, Bad Lauterberg im Harz, Germany.

Aims: We aimed to quantify the exposure to physical exercise associated with professional, recreational, or traffic-related activities in patients with type 2 diabetes, which may provoke or aggravate hypoglycaemic episodes, and to assess whether such risks determine the choice of medications minimizing the risk of hypoglycaemia.

Methods: In total, 203 patients with type 2 diabetes (98 women, 105 men, age 65 [56;72; median, inter-quartile range] years, diabetes duration 10 [5;15] years) were recruited from a German diabetes practice. A questionnaire assessed their engagement in professional, recreational, or traffic-related activities. Read More

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http://dx.doi.org/10.1007/s00592-020-01502-yDOI Listing

Cardiac autonomic modulation in type 1 diabetes during exercise-heat stress.

Acta Diabetol 2020 Mar 6. Epub 2020 Mar 6.

Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, 125 University, Room 367, Montpetit Hall, Ottawa, ON, K1N 6N5, Canada.

Aims: Cardiac autonomic modulation, as assessed by heart rate variability (HRV), is independently attenuated by both type 1 diabetes (T1D) and exercise-heat stress, although their combined effects remain unclear. We therefore assessed HRV during exercise-heat stress in young individuals (18-37 years) with (n = 14) and without type 1 diabetes (n = 14).

Methods: Participants completed 30-min seated rest and three, 30-min bouts of semi-recumbent cycling at light, moderate, and vigorous metabolic heat productions (200, 250, 300 W/m, respectively), each followed by 30-min recovery. Read More

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http://dx.doi.org/10.1007/s00592-020-01505-9DOI Listing

High glucose concentration produces a short-term increase in pERK1/2 and p85 proteins, having a direct angiogenetic effect by an action similar to VEGF.

Acta Diabetol 2020 Mar 4. Epub 2020 Mar 4.

Department of Medicine and Health Science "V. Tiberio", University of Molise, Campobasso, Italy.

Aims: Excessive glucose serum concentration, endothelial dysfunction and microangiopathy are key features of diabetes mellitus, being both diagnostic parameters and pathogenetic mechanisms. Vascular endothelial growth factor (VEGF) is importantly implicated in the physiology and pathology of blood vessels, including diabetic vascular damage.

Methods: These factors certainly affect endothelial cells, and to evaluate mechanisms involved, we took advantage of telomerase-immortalized human microvascular endothelial (TIME) cells. Read More

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http://dx.doi.org/10.1007/s00592-020-01501-zDOI Listing

The prognostic role of peak glycemia and glucose variability in trauma: a single-center investigation.

Acta Diabetol 2020 Mar 3. Epub 2020 Mar 3.

Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 1, 50134, Florence, Italy.

Aim: Admission hyperglycemia and glucose variability were associated with mortality in critically ill patients, but data on trauma patients are to date scarce and heterogeneous.

Methods: We assessed the prognostic role of ICU death of admission and peak glycemia and glucose variability (indicated by the standard deviation of mean glucose levels and the coefficient of variation of glucose) in 252 patients consecutively admitted for trauma in our ICU (January 1, 2016-December 31, 2018).

Results: The in-ICU mortality rate was 17% (43/252). Read More

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http://dx.doi.org/10.1007/s00592-020-01493-wDOI Listing

Genomic ancestry as a risk factor for diabetic retinopathy in patients with type 1 diabetes from an admixed population: a nested case-control study in Brazil.

Acta Diabetol 2020 Mar 3. Epub 2020 Mar 3.

Department of Internal Medicine, Diabetes Unit, Rio de Janeiro State University (UERJ), Boulevard 28 de Setembro, 77- 3º andar - Vila Isabel, Rio de Janeiro, Rio de Janeiro, CEP 20551-030, Brazil.

Aims: The influence of genetic factors on the development and progression of diabetic retinopathy is still unclear. Previous studies showed controversial results. We aimed to characterize the relationship between genomic ancestry and self-reported color/race with severe diabetic retinopathy in patients with type 1 diabetes belonging to a highly admixed population. Read More

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http://dx.doi.org/10.1007/s00592-020-01498-5DOI Listing

Availability of and access to continuous subcutaneous insulin infusion therapy for adults with type 1 diabetes in Ireland.

Acta Diabetol 2020 Mar 2. Epub 2020 Mar 2.

3U Diabetes, RCSI: University of Medicine and Health Sciences, Dublin, Ireland.

Aims: The uptake of continuous subcutaneous insulin infusion (CSII) is low in adults with type 1 diabetes mellitus (T1DM) in Ireland, compared to other countries where CSII is reimbursed. To explore the reasons for the low uptake, this study aims to investigate the availability of CSII in adult diabetes clinics in Ireland.

Methods: A national survey of all adult diabetes clinics (public and private) in Ireland was conducted and completed anonymously by the lead physician/diabetes nurse specialist in each clinic. Read More

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http://dx.doi.org/10.1007/s00592-020-01497-6DOI Listing

Embryonic stem cell extracts improve wound healing in diabetic mice.

Acta Diabetol 2020 Mar 2. Epub 2020 Mar 2.

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, DIBIC L. Sacco, Università degli Studi di Milano, Milan, Italy.

Aims/hypothesis: Impaired wound healing significantly impacts morbidity and mortality in diabetic patients, necessitating the development of novel treatments to improve the wound healing process. We here investigated the topical use of acellular embryonic stem cell extracts (EXTs) in wound healing in diabetic db/db mice.

Methods: Wounds were induced in diabetic db/db mice, which were subsequently treated with EXTs, with 3T3 fibroblast cell line protein extracts (3T3XTs) or with saline as a control. Read More

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http://dx.doi.org/10.1007/s00592-020-01500-0DOI Listing

Low brain-derived neurotrophic factor protein levels and single-nucleotide polymorphism Val66Met are associated with peripheral neuropathy in type II diabetic patients.

Acta Diabetol 2020 Mar 2. Epub 2020 Mar 2.

Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Background: Studies by our group demonstrated brain-derived neurotrophic factor (BDNF) levels in blood and BDNF-Val66met-SNP as potential biomarkers in chemotherapy-induced peripheral neuropathy. Here, we evaluate symptoms of peripheral neuropathy (PN) and depression in patients with type II diabetes mellitus in search of an association with serum BDNF levels and the Val66Met-SNP.

Methods: In total, 90 patients enrolled in the study; 23 (25. Read More

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http://dx.doi.org/10.1007/s00592-020-01508-6DOI Listing

Baseline SD-OCT characteristics of diabetic macular oedema patterns can predict morphological features and timing of recurrence in patients treated with dexamethasone intravitreal implants.

Acta Diabetol 2020 Feb 29. Epub 2020 Feb 29.

IRCCS - Fondazione Bietti, Rome, Italy.

Aims: To evaluate the timing and spectral-domain optical coherence tomography (SD-OCT) features of diabetic macular oedema (DME) recurrence according to baseline OCT patterns in patients treated with dexamethasone implant (DEX-I).

Methods: This is a retrospective observational study (72 eyes/65 patients). Best-corrected visual acuity, timing of DME recurrence, and SD-OCT pattern [intraretinal cysts (IRC), IRC plus subretinal fluid (mixed), external limiting membrane (ELM), ellipsoid (IS/OS) layer integrity] were assessed at baseline and monthly until first DME recurrence. Read More

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http://dx.doi.org/10.1007/s00592-020-01504-wDOI Listing
February 2020

Profile of non-responder and late responder patients treated for diabetic macular edema: systemic and ocular factors.

Acta Diabetol 2020 Feb 29. Epub 2020 Feb 29.

Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.

Diabetic macular edema (DME) treatment represents a challenge for the ophthalmologists, and several aspects of real treatment expectancy are still being discussed and not yet fully elucidated. A univocal definition of responsiveness to treatment has not been reached. How the clinicians can evaluate the therapeutic success? The evaluation of systemic and ocular factors should help in this complex management. Read More

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http://dx.doi.org/10.1007/s00592-020-01496-7DOI Listing
February 2020

Diets naturally rich in polyphenols and/or long-chain n-3 polyunsaturated fatty acids differently affect microbiota composition in high-cardiometabolic-risk individuals.

Acta Diabetol 2020 Feb 29. Epub 2020 Feb 29.

Department of Clinical Medicine and Surgery, University of Naples "Federico II", 5, Sergio Pansini, 80131, Naples, Italy.

Aims: Gut microbiota significantly impacts human health and is influenced by dietary changes. We evaluated the effects of diets naturally rich in polyphenols (PP) and/or long-chain n-3 polyunsaturated fatty acids (LCn3) on microbiota composition in an ancillary analysis of a randomized controlled trial in individuals at high cardiometabolic risk.

Methods: Seventy-eight individuals with high waist circumference and at least one additional component of the metabolic syndrome were randomized to an isoenergetic 8-week diet: (a) low LCn3 and PP; (b) high LCn3; (c) high PP; or (d) high LCn3 and PP. Read More

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http://dx.doi.org/10.1007/s00592-020-01494-9DOI Listing
February 2020
2.399 Impact Factor

Hyperreflective foci in diabetic macular edema with serous retinal detachment: association with dyslipidemia.

Acta Diabetol 2020 Feb 29. Epub 2020 Feb 29.

Department of Ophthalmology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon, 16499, Korea.

Aims: Hyperreflective foci (HF), detected in the retina of diabetic patients, suggest the presence of microglial activation and migration, while controversies still remain for the origin of HF to be precursors of hard exudates. We investigated the presence of HF and their association with dyslipidemia in serous retinal detachment (SRD)-type diabetic macular edema (DME).

Methods: Forty-two eyes in 42 patients with diabetic retinopathy (DR) and 22 eyes in 22 patients with branch retinal vascular occlusion (BRVO) showing macular edema were included in this study. Read More

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http://dx.doi.org/10.1007/s00592-020-01495-8DOI Listing
February 2020

Genetic determinants of gestational diabetes mellitus: a case-control study in two independent populations.

Acta Diabetol 2020 Feb 29. Epub 2020 Feb 29.

Shanghai Key Laboratory for Molecular Imaging, University of Medicine and Health Sciences, Shanghai, People's Republic of China.

Background: Genetic risk score (GRS) is more informative to identify the complicated associations between variants of genes and disease. Considering similar pathogenesis and shared genetic predispositions between gestational diabetes mellitus (GDM) and type 2 diabetes/obesity, we conducted this study to explore whether the GRS model integrating variants related to type 2 diabetes/obesity is also associated with GDM risk.

Methods: A population-based case-control study that included 1429 subjects was conducted to investigate the association between the GRS model and GDM risk, which were analyzed employing stratified logistic regression analysis with the adjustment for age, BMI, parity and family history of diabetes. Read More

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http://dx.doi.org/10.1007/s00592-020-01485-wDOI Listing
February 2020
2.399 Impact Factor

Nurse-managed basal-bolus versus sliding-scale insulin regimen in subjects with hyperglycemia at admission for orthopedic surgery: a propensity score approach.

Acta Diabetol 2020 Feb 25. Epub 2020 Feb 25.

Department of Medical and Surgical Sciences (DIMEC), "Alma Mater" University, 9, Via Massarenti, 40138, Bologna, Italy.

Aims: A sliding-scale (SS) regimen is discouraged to correct hyperglycemia in hospital patients, but there is resistance to adoption of basal-bolus (BB) treatment in surgical units. We tested the feasibility and the effects of a nurse-based BB regimen in orthopedic surgery.

Methods: Following an intense training to implement a protocol amenable by nurses, a group of patients admitted with hyperglycemia in an orthopedic institute were prospectively followed according to a basal-bolus insulin regimen (BB, n = 80). Read More

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http://dx.doi.org/10.1007/s00592-020-01503-xDOI Listing
February 2020

Differential unfolded protein response in skeletal muscle from non-diabetic glucose tolerant or intolerant patients with obesity before and after bariatric surgery.

Acta Diabetol 2020 Feb 21. Epub 2020 Feb 21.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France.

Aims: Not all people with obesity become glucose intolerant, suggesting differential activation of cellular pathways. The unfolded protein response (UPR) may contribute to the development of insulin resistance in several organs, but its role in skeletal muscle remains debated. Therefore, we explored the UPR activation in muscle from non-diabetic glucose tolerant or intolerant patients with obesity and the impact of bariatric procedures. Read More

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http://dx.doi.org/10.1007/s00592-020-01490-zDOI Listing
February 2020

Analysis via Markov decision process to evaluate glycemic control strategies of a large retrospective cohort with type 2 diabetes: the ameliorate study.

Acta Diabetol 2020 Feb 21. Epub 2020 Feb 21.

Cardiovascular and Metabolic Disorders Programme, Duke-NUS Medical School, Singapore, Singapore.

Aims: Our aim was to explore optimal treatment decisions for HbA control for type 2 diabetes mellitus patients and assess the impact on potential improvements in quality of life compared with current guidelines.

Methods: We analyzed a large dataset of HbA levels, diabetes-related key risk factors and medication dispensed to 70,069 patients with type 2 diabetes from polyclinics and a large public hospital in Singapore during January 1, 2008, to December 31, 2015. A Markov decision process (MDP) model was developed to determine the optimal treatment policy concerning medication management for glycemic control over a long-term treatment period. Read More

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http://dx.doi.org/10.1007/s00592-020-01492-xDOI Listing
February 2020
2.399 Impact Factor

Fulminant type 1 diabetes in Caucasians: a new Spanish case and the first related to thiazides.

Acta Diabetol 2020 Feb 21. Epub 2020 Feb 21.

Department of Endocrinology, Hospital Universitario del Tajo, 28300, Aranjuez, Spain.

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http://dx.doi.org/10.1007/s00592-020-01491-yDOI Listing
February 2020