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    1785 results match your criteria Acta diabetologica[Journal]

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    Heterogeneity of gestational diabetes (GDM) and long-term risk of diabetes and metabolic syndrome: findings from the RADIEL study follow-up.
    Acta Diabetol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
    Aims: To assess the metabolic health of obese and non-obese women at high GDM risk 5 years postpartum.

    Methods: This is a secondary analysis of the 5-year follow-up of the RADIEL GDM prevention study including 333 women at high GDM risk (BMI ≥ 30 kg/mand/or previous GDM). Five years postpartum metabolic health was assessed including anthropometric measurements, oral glucose tolerance test, lipid metabolism, and body composition as well as medical history questionnaires. Read More

    Work-loss years among people diagnosed with diabetes: a reappraisal from a life course perspective.
    Acta Diabetol 2018 Feb 17. Epub 2018 Feb 17.
    Folkhälsan Research Center, Helsinki, Finland.
    Aims: Early exit from the workforce has been proposed to be one of the unfavorable consequences of diabetes. We examined whether early exit from the workforce differed between persons who were and were not diagnosed with diabetes during their work career.

    Methods: The cohort included 12,726 individuals of the Helsinki Birth Cohort Study, born between 1934 and 1944. Read More

    The risk of type 2 diabetes mellitus according to the categories of body mass index: the Korean Genome and Epidemiology Study (KoGES).
    Acta Diabetol 2018 Feb 17. Epub 2018 Feb 17.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Aims: Obesity is an established risk factor for type 2 diabetes mellitus (T2DM). However, there is limited information on the pattern of relationship between the risk for T2DM and body mass index (BMI) categories including underweight and overweight. Thus, this study was to evaluate the risk of T2DM according to BMI categories defined by Asian-specific cutoff of BMI. Read More

    Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy.
    Acta Diabetol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Yuexiu District, Guangzhou, Guangdong, China.
    Aims: To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA).

    Methods: A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Read More

    The effect of n-3 PUFAs on circulating adiponectin and leptin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.
    Acta Diabetol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
    Aim: N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines. Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes, we conducted a systematic review and meta-analysis study of randomized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes.

    Methods: The electronic databases, without regard to language restrictions including PubMed/Medline, Google Scholar, SCOPUS and ISI Web of Science until August 2017, were used to identify randomized controlled trials that assessed the effect of n-3 PUFAs on serum leptin and adiponectin concentrations in type 2 diabetes. Read More

    Comparative evaluation of pharmacokinetics and pharmacodynamics of insulin glargine (Glaritus) and Lantusin healthy subjects: a double-blind, randomized clamp study.
    Acta Diabetol 2018 Feb 16. Epub 2018 Feb 16.
    Centre for Diabetes and Endocrine Care, Bengaluru, India.
    Aims: The objective of the study was to compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties of an insulin glargine formulation, Glaritus(test) with the innovator's formulation Lantus(reference) using the euglycemic clamp technique in a single-dose, double-blind, randomized, two sequences, four-period replicate crossover study in healthy volunteers (n = 40).

    Methods: Subjects received subcutaneous administration of the insulin glargine (0.4 IU/kg) formulation at two occasions for test and reference and a 20% glucose solution was infused at variable rate to maintain euglycemia for 24 h. Read More

    Two-hour post-challenge glucose is a better predictor of adverse outcome after myocardial infarction than fasting or admission glucose in patients without diabetes.
    Acta Diabetol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, University of Hull, Kingston upon Hull, UK.
    Aims: We evaluate prevalence of new abnormal glucose tolerance (AGT) in post-MI survivors without known diabetes (DM) if guidelines are followed and compare the ability of admission (APG), fasting (FPG) and 2-h post-load plasma glucose (2h-PG) to predict prognosis.

    Methods: A total of 674 patients were followed up for 4 years for incidence of major adverse cardiovascular events (MACE) of cardiovascular death, non-fatal re-infarction or non-haemorrhagic stroke. Ability of models including APG, FPG and 2h-PG to predict MACE was compared. Read More

    Association between IgH enhancer hs1.2 and type 1 diabetes.
    Acta Diabetol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Biology Enrico Calef, Tor Vergata University, Viale della Ricerca Scientifica, 1, 00133, Rome, Italy.
    Aim: To investigate the association of alleles of the 3' immunoglobulin heavy-chain regulatory region 1 (3'RR-1) enhancer hs1.2 in patients with type 1 diabetes (T1D).

    Methods: Eighty-one patients with T1D [among which 12 had concomitant coeliac disease (CD) and 25 an autoimmune thyroid disease (AITD)] were compared to 248 healthy individuals. Read More

    Comparative safety and efficacy of insulin degludec with insulin glargine in type 2 and type 1 diabetes: a meta-analysis of randomized controlled trials.
    Acta Diabetol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Cardiology, Affiliated Drum Tower Hospital, Nanjing University School of Medicine, 321 Zhongshan Road, Nanjing, 210008, Jiangsu Province, China.
    Aims: To determine the safety and efficacy of insulin degludec versus glargine in patients with type 1 (T1D) and type 2 (T2D) diabetes mellitus.

    Methods: Databases were searched until July 5, 2017. We included randomized controlled trials comparing degludec with glargine in diabetic patients, each with a minimum of 16 weeks of follow-up. Read More

    Identification of megakaryocytes as a target of advanced glycation end products in diabetic complications in bone marrow.
    Acta Diabetol 2018 Feb 8. Epub 2018 Feb 8.
    MOH Key Lab of Thrombosis and Hemostasis, Collaborative Innovation Center of Hematology-Thrombosis and Hemostasis Group, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, 708 Renmin Road, Suzhou, 215007, China.
    Aims: To define the possible effect of diabetic conditions on megakaryocytes, the long-know precursors of platelets and lately characterized modulator of hematopoietic stem quiescence-activation transition.

    Methods: Megakaryoblastic MEG-01 cell culture and TPO/SCF/IL-3-induced differentiation of human umbilical blood mononuclear cells toward megakaryocytes were used to test effects of glycated bovine serum albumin (BSA-AGEs). The ob/ob mice and streptozotocin-treated mice were used as models of hyperglycemia. Read More

    Does ancestry influence health-related quality of life in type 1 diabetes patients? A nationwide study in Brazil.
    Acta Diabetol 2018 Feb 3. Epub 2018 Feb 3.
    Diabetes Unit, Department of Internal Medicine, State University of Rio de Janeiro (UERJ), Boulevard 28 de Setembro, 77- 3º andar - Vila Isabel, Rio de Janeiro, RJ, CEP 20551-030, Brazil.
    Aims: The aim of the present study was to evaluate the relationship between self-reported color/race and genomic ancestry with HRQoL of patients with type 1 diabetes in a highly admixed population.

    Methods: This was a nationwide, cross-sectional study conducted with 1760 patients with type 1 diabetes from 2011 to 2014 at public clinics in all five Brazilian geographical regions. Information on HRQoL was obtained from two self-completed questionnaires: Short Form-6 Dimensions (SF-6D) and EuroQol-5 Dimensions (EQ-5D) with a visual analogue scale (EQ-VAS). Read More

    Bisphenol A is not associated with a 5-year incidence of type 2 diabetes: a prospective nested case-control study.
    Acta Diabetol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Youyi Street Yuanjiagang, Yuzhong District, Chongqing, China.
    Aims: The relationship between bisphenol A (BPA) and diabetes remains controversial. This study aims to investigate whether serum BPA level could predict the 5-year incidence of type 2 diabetes (T2D).

    Methods: A nested case-control study was performed among Chinese who participated in the environment, inflammation and metabolic diseases study (2008-2013). Read More

    Claimed effects, outcome variables and methods of measurement for health claims proposed under European Community Regulation 1924/2006 in the area of blood glucose and insulin concentrations.
    Acta Diabetol 2018 Jan 30. Epub 2018 Jan 30.
    The Laboratory of Phytochemicals in Physiology, Department of Food and Drug, University of Parma, Medical School, Building A, Via Volturno 39, 43125, Parma, Italy.
    Most requests for authorization to bear health claims under Articles 13(5) and 14 related to blood glucose and insulin concentration/regulation presented to the European Food Safety Authority (EFSA) receive a negative opinion. Reasons for such decisions are mainly ascribable to poor substantiation of the claimed effects. In this scenario, a project was carried out aiming at critically analysing the outcome variables (OVs) and methods of measurement (MMs) to be used to substantiate health claims, with the final purpose to improve the quality of applications provided by stakeholders to EFSA. Read More

    The 1-h post-load plasma glucose as a novel biomarker for diagnosing dysglycemia.
    Acta Diabetol 2018 Jan 30. Epub 2018 Jan 30.
    NYU Langone Diabetes Prevention Program, Division of Endocrinology and Metabolism, Department of Medicine, NYU School of Medicine, 530 First Avenue, Schwartz East, Suite 5E, New York, NY, 10016, USA.
    Identifying the earliest moment for intervention to avert progression to prediabetes and diabetes in high-risk individuals is a substantial challenge. As β-cell function is already compromised in prediabetes, attention should therefore be focused on identifying high-risk individuals earlier in the so-called pre-prediabetes stage. Biomarkers to monitor progression and identify the time point at which β-cell dysfunction occurs are therefore critically needed. Read More

    No selection, but higher satisfaction of people participating in the disease management programme diabetes type 2 in Germany.
    Acta Diabetol 2018 Jan 30. Epub 2018 Jan 30.
    Division of Endocrinology and Metabolic Diseases, Department of Internal Medicine III, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
    Aims: We analysed metabolic control, complications and satisfaction in people with and without DMP participation.

    Methods: We retrospectively analysed the German data of the GUIDANCE study. The general practices included (n = 38) were selected from the physicians' register of the Thuringian Association of Statutory Health Insurance Physicians. Read More

    Prevalence and management of diabetes in immigrants resident in the Lombardy Region: the importance of ethnicity and duration of stay.
    Acta Diabetol 2018 Jan 22. Epub 2018 Jan 22.
    Laboratory of Cardiovascular Prevention, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Via Giuseppe La Masa 19, 20156, Milan, Italy.
    Aims: To describe the prevalence and management of diabetes among immigrants according to ethnic group and duration of stay, compared to Italian citizens.

    Methods: Diabetic immigrant and Italian residents aged 20-69 years in the administrative database of the Lombardy Region. Immigrants were classified by region of origin and as long-term residents (LTR) and short-term residents (STR). Read More

    The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial.
    Acta Diabetol 2018 Jan 22. Epub 2018 Jan 22.
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
    Aims: Oxidative stress plays a pivotal role in the pathogenesis of type 2 diabetes (T2D). In vitro and animal studies have shown that resveratrol exerts an antioxidant effect, but clinical trials addressing this effect in patients with T2D are limited. The aim of this study was to determine whether resveratrol supplementation affects oxidative stress markers in a randomized, placebo-controlled, double-blind clinical trial. Read More

    Insulin resistance and bone: a biological partnership.
    Acta Diabetol 2018 Jan 15. Epub 2018 Jan 15.
    Division of Endocrinology and Diabetes, Università Campus Bio-Medico di Roma, Rome, Italy.
    Despite a clear association between type 2 diabetes (T2D) and fracture risk, the pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is the primary defect in T2D. Insulin signalling regulates both bone formation and bone resorption, but whether insulin resistance can affect bone has not been established. Read More

    Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation.
    Acta Diabetol 2018 Jan 12. Epub 2018 Jan 12.
    Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
    Aims: Sirtuin-1 (SIRT-1) down-regulation in type 2 diabetes mellitus (T2DM) has been associated with epigenetic markers of oxidative stress. We herein aim to evaluate whether an increase in SIRT-1 expression affects histone 3 acetylation at the 56 lysine residue (H3K56ac) in T2DM patients randomly selected to receive either resveratrol (40 mg or 500 mg) or a placebo for 6 months. The primary outcome is changes in the H3K56ac level by variation in SIRT-1 expression and the secondary outcome is the evidence of association between SIRT-1 level, antioxidant markers (TAS), and metabolic variables. Read More

    Levels of serum uric acid at admission for hypoglycaemia predict 1-year mortality.
    Acta Diabetol 2018 Jan 11. Epub 2018 Jan 11.
    Diabetology Unit, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, 16132, Genoa, Italy.
    Aims: Hypoglycaemia represents a critical burden with clinical and social consequences in the management of diabetes. Serum uric acid (SUA) has been associated with cardiovascular diseases (CVD), but no conclusive findings are available nowadays in patients suffering from hypoglycaemia. We investigated whether SUA levels at the time of hypoglycaemia could predict all-cause mortality after 1-year follow-up. Read More

    Gestational diabetes and risk of cardiovascular disease up to 25 years after pregnancy: a retrospective cohort study.
    Acta Diabetol 2018 Jan 11. Epub 2018 Jan 11.
    University of Montreal Hospital Research Centre, Montreal, QC, Canada.
    Aims: The risk of cardiovascular disease in women with gestational diabetes is poorly understood. We sought to determine whether gestational diabetes increases the risk of cardiovascular disease more than two decades after pregnancy.

    Methods: We carried out a retrospective cohort study of 1,070,667 women who delivered infants in hospitals within Quebec, Canada, between 1989 and 2013. Read More

    Autoantibodies against zinc transporter 8 are related to age and metabolic state in patients with newly diagnosed autoimmune diabetes.
    Acta Diabetol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Mickiewicza Street 2, 60-101, Poznan, Poland.
    Aims: To assess the prevalence of ZnT8-ab and its correlation to other autoimmune markers and diabetic ketoacidosis occurrence in children and adults with T1DM onset.

    Methods: The study included 367 patients (218 children; 149 adults) at the T1DM onset. Selected diabetes-related autoantibodies such as GAD-ab, IA2-ab, ZnT8-ab were tested before the initiation of insulin therapy. Read More

    The metabolism and transport of 1,5-anhydroglucitol in cells.
    Acta Diabetol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai, 200233, China.
    Aims: Our previous studies demonstrated that serum 1,5-anhydroglucitol (1,5-AG) levels increased slightly rather than declined after an acute glucose load. Therefore, the current study aims at exploring the transport and metabolic characteristics of 1,5-AG, as well as the effect of glucose on 1,5-AG transport.

    Methods: Kand Vwere determined to measure the affinity of glucose oxidase (GOD) and hexokinase (HK) for 1,5-AG and glucose. Read More

    Age affects the prognostic impact of diabetes in chronic heart failure.
    Acta Diabetol 2018 Jan 8. Epub 2018 Jan 8.
    Serviço de Medicina Interna, Centro Hospitalar São João, Porto, Portugal.
    Aims: Increasing age is an established prognostic determinant in chronic heart failure (HF). Diabetes often complicates HF in its course and appears to worsen HF prognosis. A differential impact of diabetes depending on patients' age was not yet studied. Read More

    A novel LIPS assay for insulin autoantibodies.
    Acta Diabetol 2018 Jan 5. Epub 2018 Jan 5.
    Human Pathology Genomic Diagnostics Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
    Aims: Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobinding micro-assay (RBA) for measuring IAA. Our aim was to replace RBA with a novel non-radioactive IAA Luciferase Immuno Precipitation System (LIPS) assay with improved performance. Read More

    Diabetes and number of years of life lost with and without cardiovascular disease: a multi-state homogeneous semi-Markov model.
    Acta Diabetol 2018 Jan 3. Epub 2018 Jan 3.
    Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Floor 3th, Number 24, Yemen Street, Shahid Chamran Highway, P.O. Box: 19395-4763, Tehran, Iran.
    Aims: We quantified the impact of type 2 diabetes on incidence of non-fatal cardiovascular disease (CVD) and mortality, considering CVD as a continuum from occurrence of diabetes to the end point, and estimated the 15-year life expectancy with and without CVD.

    Methods: A total of 7239 Iranian adults (3246 men), aged ≥ 30 years, were followed from 1999 to 2014. We applied a multi-state semi-Markov model with three transitions including CVD-free to non-fatal CVD, CVD-free to death and non-fatal CVD to death, and studied the influence of diabetes on each transition rate, stratifying by sex and adjusting for confounders. Read More

    Maternal educational level and the risk of persistent post-partum glucose metabolism disorders in women with gestational diabetes mellitus.
    Acta Diabetol 2017 Dec 29. Epub 2017 Dec 29.
    Unit of Population Epidemiology, Department of Community Medicine, Primary Care, and Emergency Medicine, Geneva University Hospitals, Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.
    Aims: Gestational diabetes mellitus (GDM) occurs in 5-15% of pregnancies, and lower maternal educational attainment has been associated with higher risk of GDM. We aimed to determine if maternal education level is associated with persistent post-partum glucose metabolism disorders in women with GDM.

    Methods: Retrospective cohort study of women with GDM followed in 25 Portuguese health institutions between 2008 and 2012. Read More

    Family history of diabetes and its relationship with insulin secretion and insulin sensitivity in Iraqi immigrants and native Swedes: a population-based cohort study.
    Acta Diabetol 2017 Dec 22. Epub 2017 Dec 22.
    Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
    Aims: Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described.

    Methods: Citizens of Malmö, Sweden, aged 30-75 years born in Iraq or Sweden were invited to participate in this population-based study. Read More

    Advances in micro- and nanotechnologies for the GLP-1-based therapy and imaging of pancreatic beta-cells.
    Acta Diabetol 2017 Dec 20. Epub 2017 Dec 20.
    Barnstable Brown Kentucky Diabetes Center, University of Kentucky, 900 S. Limestone, CTW 469, Lexington, KY, 40536, USA.
    Therapies to prevent diabetes in particular the progressive loss of β-cell mass and function and/or to improve the dysregulated metabolism associated with diabetes are highly sought. The incretin-based therapy comprising GLP-1R agonists and DPP-4 inhibitors have represented a major focus of pharmaceutical R&D over the last decade. The incretin hormone GLP-1 has powerful antihyperglycemic effect through direct stimulation of insulin biosynthesis and secretion within the β-cells; it normalizes β-cell sensitivity to glucose, has an antiapoptotic role, stimulates β-cell proliferation and differentiation, and inhibits glucagon secretion. Read More

    New treatment options for lipid-lowering therapy in subjects with type 2 diabetes.
    Acta Diabetol 2017 Dec 19. Epub 2017 Dec 19.
    Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
    Dyslipidemias represent a variety of quantitative and/or qualitative lipoprotein abnormalities. According to etiology, we distinguish primary dyslipidemias with strictly genetic background and secondary ones with their origin in other disease or pathological states. Diabetic dyslipidemia is a type of secondary dyslipidemia and plays an important role in determining the cardiovascular risk of subjects with type 2 diabetes. Read More

    Treatment of mild-to-moderate hypoglycemia in patients with type 1 diabetes treated with insulin pump therapy: are current recommendations effective?
    Acta Diabetol 2017 Dec 9. Epub 2017 Dec 9.
    Institut de recherches cliniques de Montréal (IRCM), 110 avenue des Pins Ouest, Montreal, QC, H2W 1R7, Canada.
    Aims: Mild-to-moderate hypoglycemia (blood glucose < 4.0 mmol/L) is recommended to be treated with 15 g of carbohydrates and to repeat the treatment if hypoglycemia persists after 15 min. This recommendation was established before intensive insulin therapy and based on studies using insulin with different pharmacokinetic profiles from actual insulin analogs showing that 15 g of glucose increases blood glucose by ~ 1. Read More

    Intensive dietary intervention promoting the Mediterranean diet in people with high cardiometabolic risk: a non-randomized study.
    Acta Diabetol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Clinical Medicine and Surgery, Federico II University Hospital, Via Pansini 5, 80131, Naples, Italy.
    Aims: Mediterranean diet (MD) is acknowledged to exert a number of beneficial health effects. We assessed the efficacy and the durability of a 3-month intensive dietary intervention aimed at implementing the MD on body weight and cardiometabolic risk factors in subjects at high risk.

    Methods: One hundred and sixteen subjects participated in the study (71 assigned to the intensive intervention and 45 to the conventional intervention). Read More

    Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy: the AMD-Annals initiative.
    Acta Diabetol 2018 Feb 5;55(2):193-199. Epub 2017 Dec 5.
    Diabetes Research Institute, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
    Aim: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age.

    Methods: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8. Read More

    Teleconsultation in type 1 diabetes mellitus (TELEDIABE).
    Acta Diabetol 2018 Feb 5;55(2):185-192. Epub 2017 Dec 5.
    Medicine Department, Legnano ASST Ovest Milanese, Legnano, Italy.
    Aims: The growing incidence of diabetes and the need to contain healthcare costs empower the necessity to identify new models of care. Telemedicine offers an acknowledged instrument to provide clinical health care at a distance, increasing patient compliance and the achievement of therapeutical goals. The objective was to test the feasibility and the efficacy in the improvement of the glycemic control of the teleconsultation for patients with type 1 diabetes mellitus. Read More

    Association between multimorbidity and mean platelet volume in diabetic patients with acute myocardial infarction.
    Acta Diabetol 2018 Feb 30;55(2):175-183. Epub 2017 Nov 30.
    Third Department of Cardiology, Silesian Center for Heart Disease, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
    Aims: Diabetes mellitus (DM) is one of the most frequently detected conditions in multimorbid disease clusters. Platelet activation is one of the key mechanisms underlying atherothrombosis in acute myocardial infarction. Available data link mean platelet volume (MPV) to poor prognosis not only in cardiovascular and non-cardiovascular disease. Read More

    The shifting paradigm of a "cure" for type 1 diabetes: is technology replacing immune-based therapies?
    Acta Diabetol 2018 Feb 29;55(2):117-120. Epub 2017 Nov 29.
    Type 1 Diabetes Center, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.
    Nearly 50 years after the autoimmune nature of type 1 diabetes was discovered, no therapy has been approved to alter the course of the disease at any stage. However, during that same period, technology has been delivering tools to help patients achieve better glycemic control and reduce the burden of the disease. With the imminent arrival of fully automated artificial pancreas systems that will continue to improve control and quality of life, it appears that we are on the verge of a major technological breakthrough that will significantly impact diabetes care. Read More

    Association of diabetes therapy-related quality of life and physical activity levels in patients with type 2 diabetes receiving medication therapy: the Diabetes Distress and Care Registry at Tenri (DDCRT 17).
    Acta Diabetol 2018 Feb 29;55(2):165-173. Epub 2017 Nov 29.
    Department of Diabetology, Nara Medical University, Kashihara, Nara, 634-8521, Japan.
    Aim: To examine the association between diabetes therapy-related quality of life (DTR-QOL) and physical activity levels, and identify factors associated with high diabetes therapy-related quality of life.

    Methods: Cross-sectional data from 2970 patients with type 2 diabetes in a Japanese diabetes registry were assessed for independent correlations between DTR-QOL (domains 1-4) and high physical activity levels. Data collected by the International Physical Activity Questionnaire were analyzed by logistic regression and adjusted for potential confounders. Read More

    Functional status mediates the association between peripheral neuropathy and health-related quality of life in individuals with diabetes.
    Acta Diabetol 2018 Feb 28;55(2):155-164. Epub 2017 Nov 28.
    Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, Singapore, 117549, Singapore.
    Aims: To examine differences in health-related quality of life (HRQoL) between patients with and without diabetic peripheral neuropathy (DPN), and whether these differences can be explained by functional deficits.

    Methods: This was a cross-sectional study of 160 patients with type 2 diabetes mellitus, 80 with DPN and 80 without. Assessments included HRQoL (health utility score derived from EQ-5D-5L), functional status measurements [muscle strength, timed up and go (TUG), five times sit-to-stand (FTSTS), functional reach, body sway velocity] and self-reported balance confidence [Activities-specific Balance Confidence (ABC) scale]. Read More

    Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial.
    Acta Diabetol 2018 Feb 18;55(2):149-153. Epub 2017 Nov 18.
    Department of Clinical Medicine and Surgery, "Federico II" University, 5, Sergio Pansini, 80131, Naples, Italy.
    Aims: Due to their different chemical structures and metabolism, polyphenol subclasses may have specific impact on cardiometabolic risk factors. Our aim was to evaluate whether the intake of different polyphenol subclasses is associated with clinical outcomes beneficially improved by polyphenols in a nutritional trial performed by our group (postprandial lipid response, glucose homeostasis, early insulin secretion and oxidative stress).

    Methods: The present study is a secondary analysis of a nutritional intervention study with a diet naturally rich in polyphenols. Read More

    The potential role of the osteopontin-osteocalcin-osteoprotegerin triad in the pathogenesis of prediabetes in humans.
    Acta Diabetol 2018 Feb 18;55(2):139-148. Epub 2017 Nov 18.
    Department of Medicine, Division of Diabetes, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.
    Aims: To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes.

    Methods: Individuals (n = 43) with NGT (BMI = 31.1 ± 1. Read More

    Substantial improvement in HbA1c following a treatment and teaching programme for people with type 2 diabetes on conventional insulin therapy in an in- and outpatient setting.
    Acta Diabetol 2018 Feb 17;55(2):131-137. Epub 2017 Nov 17.
    Endocrinology and Metabolic Diseases, Department of Internal Medicine III, Jena University Hospital, Am Klinikum 1, 07740, Jena, Germany.
    Aims: The aim of the study was to assess the efficacy of a patient education programme (DTTP) for the optimisation of conventional insulin therapy in patients with type 2 diabetes in an in- and outpatient setting.

    Methods: The study was designed as a prospective, longitudinal trial. Thirty-three people with diabetes (females 54. Read More


    Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice.
    Acta Diabetol 2018 Feb 13;55(2):121-129. Epub 2017 Nov 13.
    Laboratorio di Biochimica Analitica e Proteomica, Centro Scienze dell'Invecchiamento e Medicina Traslazionale - CeSI-MeT, Via Luigi Polacchi 11, 66100, Chieti, Italy.
    Aims: The tissue inhibitor of metalloproteinase TIMP3 is a stromal protein that restrains the activity of both protease and receptor in the extracellular matrix and has been found to be down-regulated in diabetic nephropathy (DN), the leading cause of end-stage renal disease in developed countries.

    Methods: In order to gain deeper insights on the association of loss of TIMP3 and DN, we performed differential proteomic analysis of kidney and blood metabolic profiling of wild-type and Timp3-knockout mice before and after streptozotocin (STZ) treatment, widely used to induce insulin deficiency and hyperglycemia.

    Results: Kidney proteomic data and blood metabolic profiles suggest significant alterations of peroxisomal and mitochondrial fatty acids β-oxidation in Timp3-knockout mice compared to wild-type mice under basal condition. Read More

    Health literacy in type 2 diabetes patients: a systematic review of systematic reviews.
    Acta Diabetol 2018 Jan 11;55(1):1-12. Epub 2017 Nov 11.
    Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
    Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, and searching on PubMed, CINAHL, Scopus, and Cochrane. The search covered the period between January 2006 and June 2016. Read More

    Fetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis.
    Acta Diabetol 2018 Jan 11;55(1):87-98. Epub 2017 Nov 11.
    Department of Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong Island, Hong Kong.
    Aims: Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. Read More

    Routine resting energy expenditure measurement increases effectiveness of dietary intervention in obesity.
    Acta Diabetol 2018 Jan 3;55(1):75-85. Epub 2017 Nov 3.
    Endocrinology and Metabolism, Policlinico San Donato Hospital and Scientific Institute, Via Morandi 30, 20097, San Donato Milanese, Italy.
    Aims: Primary outcome of this observational study was to compare weight changes in two groups of overweight and obese individuals: subjects who had a diet prescribed on the base of resting energy expenditure (REE) measured by indirect calorimetry and subjects whose REE was estimated by a predictive equation. In addition, we analyzed differences in weight and metabolic parameter variation in subjects with and without an adequate to predicted REE.

    Methods: We retrospectively analyzed data of 355 overweight and obese patients: 215 on a diet based on REE measured by indirect calorimetry and 140 following a diet based on REE estimated by the Harris-Benedict equation. Read More

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