1,845 results match your criteria Acta diabetologica[Journal]


Glial acetate metabolism is increased following a 72-h fast in metabolically healthy men and correlates with susceptibility to hypoglycemia.

Acta Diabetol 2018 Jun 22. Epub 2018 Jun 22.

Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.

Aims: Prior exposure to insulin-induced hypoglycemia was shown to increase glial acetate metabolism (GAM) during subsequent exposure to hypoglycemia in diabetic individuals. However, it remained unclear whether this effect was dependent on the disease state or the antecedent cause of hypoglycemia. We aimed to establish whether exposure to fasting-induced hypoglycemia was sufficient to produce alterations in GAM in non-diabetic individuals. Read More

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The effects of probiotics and synbiotic supplementation on glucose and insulin metabolism in adults with prediabetes: a double-blind randomized clinical trial.

Acta Diabetol 2018 Jun 22. Epub 2018 Jun 22.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Sedighe Tahere Research Complex, Khoram St., Isfahan, Iran.

Aims: Probiotics and/or prebiotics could be a promising approach to improve metabolic disorders by favorably modifying the gut microbial composition.

Objectives: To assess the effects of probiotics and synbiotic on glycemic indices in prediabetic individuals who are at risk of type 2 diabetes and its complications.

Methods: In a double-blind, randomized, placebo-controlled parallel-group clinical trial, 120 prediabetic adults participated and were randomly allocated to receive either probiotics or synbiotic or placebo supplements for 24 weeks. Read More

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Assessment of glucose effectiveness from short IVGTT in individuals with different degrees of glucose tolerance.

Acta Diabetol 2018 Jun 21. Epub 2018 Jun 21.

Metabolic Unit, CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127, Padova, Italy.

Aims: Minimal model analysis of intravenous glucose tolerance test (IVGTT) data represents the reference method to assess insulin sensitivity (S) and glucose effectiveness (S) that quantify the insulin-dependent and insulin-independent processes of glucose disappearance, respectively. However, test duration (3 h) and need for modeling expertise limit the applicability of this method. Aim of this study was providing a simple predictor of S applicable to short test (1 h), as previously done with S. Read More

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Diabetes, myometrium, and mitochondria in pregnant women at term.

Acta Diabetol 2018 Jun 21. Epub 2018 Jun 21.

Cellular and Metabolic Research Section, Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Blegdamsvej 3, Bygning 6.5, 2200, Copenhagen N, Denmark.

Aims: Poor myometrial contractility has been demonstrated in women at term with diabetes and decreased muscular mitochondrial content and/or function has been extensively implicated in the progression of type 2 diabetes. Alterations of the uterine mitochondrial phenotype in pregnant women with diabetes have yet to be investigated as a causal link to decreased myometrial contractility.

Methods: Observational study of 18 women with diabetes (type 2 and gestational) scheduled for an elective Caesarean section at term with matching controls. Read More

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Relationship between sleep disturbance and self-care in adults with type 2 diabetes.

Acta Diabetol 2018 Jun 21. Epub 2018 Jun 21.

Department of Biobehavioral Health Science, College of Nursing, University of Illinois at Chicago, 845 S. Damen Ave. (M/C 802), Chicago, IL, 60612, USA.

Aims: Type 2 diabetes (T2D) is a metabolic disorder requiring intensive self-care to maintain optimal glycemic control. Sleep disturbance is common in T2D patients and likely impairs glycemic control. Our aim was to examine the relationship between sleep disturbance and self-care in adults with T2D. Read More

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Correction to: The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial.

Acta Diabetol 2018 Jun 16. Epub 2018 Jun 16.

Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Oxidative stress plays a pivotal role in the pathogenesis of type 2 diabetes (T2D). In vitro and animal studies have shown that resveratrol exerts an antioxidant effect, but clinical trials addressing this effect in patients with T2D are limited. The aim of this study was to determine whether resveratrol supplementation affects oxidative stress markers in a randomized, placebo-controlled, double-blind clinical trial. Read More

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Sudden onset of immune-mediated type 1 diabetes mellitus in a 93-year-old woman: a case report.

Acta Diabetol 2018 Jun 6. Epub 2018 Jun 6.

Diabetes Research Center/Clinical Biology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.

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Choroidal thickness changes in non-treated eyes of patients with diabetes: swept-source optical coherence tomography study.

Acta Diabetol 2018 Jun 6. Epub 2018 Jun 6.

Department of Ophthalmology, Semmelweis University, Mária 39, Budapest, 1085, Hungary.

Aims: To measure choroidal thickness (CT) in diabetic eyes and its correlation with metabolic status and the severity of diabetic retinopathy (DR).

Materials And Methods: Prospective cross-sectional study using swept-source optical coherence tomography. CT maps of 96 treatment naïve eyes of 48 patients with diabetes were compared to 46 eyes of 23 healthy controls. Read More

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The relationship between sleep and cognitive function in patients with prediabetes and type 2 diabetes.

Acta Diabetol 2018 Jun 6. Epub 2018 Jun 6.

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Ratchathewi, Bangkok, 10400, Thailand.

Aims: Diabetes is linked to cognitive impairment. Sleep plays a role in memory consolidation. Sleep disturbances, commonly found in patients with diabetes, were shown to be related to cognitive dysfunction. Read More

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June 2018
4 Reads

Association analysis of copy number variations in type 2 diabetes-related susceptible genes in a Chinese population.

Acta Diabetol 2018 Jun 1. Epub 2018 Jun 1.

Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You An Men, Beijing, 100069, People's Republic of China.

Aims: Copy number variations (CNVs) have been implicated as an important genetic marker of common disease. In this study, we explored genetic effects of common CNVs in Type 2 diabetes (T2D) related susceptible genes in Chinese population.

Methods: Seven common CNV loci were selected from genes enclosing the susceptible single nucleotide polymorphisms (SNPs) of T2D confirmed by genome-wide association studies (GWAS) and replication studies conducted in east Asia population. Read More

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DPP-4 inhibitors for the treatment of type 2 diabetes: a methodology overview of systematic reviews.

Acta Diabetol 2018 Jun 1. Epub 2018 Jun 1.

School of Basic Medical Sciences, Evidence-Based Medicine Center, Lanzhou University, Lanzhou, China.

Aims: To evaluate the methodological quality of systematic reviews (SRs), and summarize evidence of important outcomes from dipeptidyl peptidase-4 inhibitors (DPP4-I) in treating type 2 diabetes mellitus (T2DM).

Methods: We included SRs of DPP4-I for the treatment of T2DM until January, 2018 by searching the Cochrane Library, PubMed, EMBASE and three Chinese databases. We evaluated the methodological qualities with the AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool and the GRADE (The Grading of Recommendations Assessment, Development and Evaluation) approach. Read More

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Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese.

Acta Diabetol 2018 May 31. Epub 2018 May 31.

State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aims: Previous genome-wide association studies reported rs1440581 was significantly associated with circulating branched chain amino acids (BCAAs) levels in Europeans. We aimed to investigate association of BCAAs related variant rs1440581 with incident T2D risk and longitudinal changes in glucose-related metabolic traits in a community-based prospective cohort of Chinese.

Methods: 6043 non-diabetic participants aged ≥ 40 years from a community-based population at baseline were included and followed-up for 5 years. Read More

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May 2018
2 Reads

Aerobic training improves platelet function in type 2 diabetic patients: role of microRNA-130a and GPIIb.

Acta Diabetol 2018 May 31. Epub 2018 May 31.

Cell-Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Aims: MicroRNAs (miRs) that are mediators of gene expression have been implicated in type 2 diabetes mellitus (T2DM). Platelet hyper-reactivity is one of the most important disorders in T2DM patients. In this study, we explored the effects of aerobic training (AT) on platelet aggregation and Glycoprotein IIb (GPIIb) receptor and miR-130a expression. Read More

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The role of sex hormone-binding globulin (SHBG), testosterone, and other sex steroids, on the development of type 2 diabetes in a cohort of community-dwelling middle-aged to elderly men.

Acta Diabetol 2018 May 29. Epub 2018 May 29.

Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Aims: Contrasting findings exist regarding the association between circulating sex hormone-binding globulin (SHBG) and testosterone levels and type 2 diabetes (T2D) in men. We examined prospective associations of SHBG and sex steroids with incident T2D in a cohort of community-dwelling men.

Methods: Participants were from a cohort study of community-dwelling (n = 2563), middle-aged to elderly men (35-80 years) from Adelaide, Australia (the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study). Read More

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Accelerometer-derived physical activity in those with cardio-metabolic disease compared to healthy adults: a UK Biobank study of 52,556 participants.

Acta Diabetol 2018 May 28. Epub 2018 May 28.

NIHR Innovation Observatory, Newcastle University, Newcastle Upon Tyne, UK.

Aim: Cardio-metabolic disease and physical activity are closely related but large-scale objective studies which measure physical activity are lacking. Using the largest accelerometer cohort to date, we aimed to investigate whether there is an association between disease status and accelerometer variables after a 5-year follow-up.

Methods: 106,053 UK Biobank participants wore a wrist-worn GENEactiv monitor. Read More

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Effect of resveratrol in type 2 diabetes oxidative stress markers: a reassessment.

Acta Diabetol 2018 Jul 23;55(7):757. Epub 2018 May 23.

National Institute of Management Studies, 201 Nirman Estate, Link Road, Malad West, Mumbai, Maharashtra, 400064, India.

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Reply to Letter to the Editor "The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial".

Acta Diabetol 2018 Jul 23;55(7):755-756. Epub 2018 May 23.

Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

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The association between age at menarche and later risk of gestational diabetes is mediated by insulin resistance.

Acta Diabetol 2018 May 22. Epub 2018 May 22.

Department of Paediatrics, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Box 116, Cambridge, CB2 0QQ, UK.

Aims: Associations have been reported between age at menarche and the later risk of gestational diabetes. However, it is not known whether these associations reflect differences in insulin sensitivity and/or pancreatic β-cell function in pregnancy.

Methods: We examined this question in women enrolled in the prospective Cambridge Baby Growth Study who recalled their age at menarche in questionnaires during pregnancy. Read More

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Adherence to special diets and its association with meeting the nutrient recommendations in individuals with type 1 diabetes.

Acta Diabetol 2018 May 18. Epub 2018 May 18.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Biomedicum Helsinki C318b, PO Box 63, 00014, Helsinki, Finland.

Aims: Not much is known about adherence to special diets in type 1 diabetes, characteristics of individuals with special diets, and whether such practices should raise concerns with respect to meeting the dietary recommendations. In this study, we assessed the frequencies of adherence to special diets, in a population of individuals with type 1 diabetes, and investigated the association between special diet adherence and dietary intake, measured as dietary patterns and nutrient intakes.

Methods: During the Finnish Diabetic Nephropathy Study visit, participants with type 1 diabetes (n = 1429) were instructed to complete a diet questionnaire inquiring about the adherence to special diets. Read More

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Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals.

Acta Diabetol 2018 May 17. Epub 2018 May 17.

Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.

Aims: Decreased insulin clearance has been reported to be associated with insulin resistance-related disorders and incident type 2 diabetes. The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance.

Methods: 440 non-diabetic individuals were stratified in tertiles according to serum UA levels. Read More

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May 2018
3 Reads

Salivary anti-coxsackievirus-B4 neutralizing activity and pattern of immune parameters in patients with type 1 diabetes: a pilot study.

Acta Diabetol 2018 May 17. Epub 2018 May 17.

Université de Lille, Faculté de Médecine, CHU de Lille, Laboratoire de Virologie EA3610, 59000, Lille, France.

Aims: Enteroviruses, especially coxsackieviruses B (CV-B), have been associated with the pathogenesis of type 1 diabetes (T1D). An anti-CV-B4 neutralizing activity in saliva of T1D patients was previously reported. Our aim was to study the association between the saliva anti-CV-B4 neutralizing activity and immune parameters in T1D patients in comparison with non-diabetic individuals. Read More

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Recent diabetes-related mortality trends in Romania.

Acta Diabetol 2018 May 17. Epub 2018 May 17.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Aims: As there are no published articles on country-level diabetes-related mortality in Romania, we aimed to investigate this aspect for the 1998-2015 period.

Methods: Anonymized demographic and diabetes-related mortality data (underlying or first secondary cause of death) were retrospectively obtained from the National Institute of Statistics/Eurostat microdata. Age-standardized mortality rates (ASMR) and their annual percentage change (APC) were analysed. Read More

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Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian.

Acta Diabetol 2018 May 17. Epub 2018 May 17.

Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Aims: To investigate whether PDCD1 gene polymorphisms are functional, and their associations with T1D risk and related clinical characteristics.

Methods: A total of 3060 Chinese Han individuals (1019 T1D patients and 2041 healthy controls) were genotyped for 4 tag single nucleotide polymorphisms (SNPs) within the PDCD1 region (rs2227982, rs7421861, rs10204525, and rs6710479) and another most studied synonymous SNP, rs2227981. In addition, 251 healthy individuals underwent an oral glucose tolerance test (OGTT); measures of insulin release and sensitivity were estimated from insulinogenic, BIGTT, Matsuda. Read More

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May 2018
3 Reads

Effect of inositol stereoisomers at different dosages in gestational diabetes: an open-label, parallel, randomized controlled trial.

Acta Diabetol 2018 May 17. Epub 2018 May 17.

Department of Medicine and Aging, School of Medicine and Health Sciences, "G. d'Annunzio" University Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy.

Aims: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women.

Methods: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27. Read More

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May 2018
1 Read

Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study.

Acta Diabetol 2018 May 12. Epub 2018 May 12.

Unit for Pediatric Endocrinology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Aims: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study.

Methods: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis. Read More

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Glucose control during kidney transplantation in type 1 diabetes patient on sensor augmented pump: a case report.

Acta Diabetol 2018 May 10. Epub 2018 May 10.

Center for Insulin Pump and Sensor, University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Vodnjanska 17, 1000, Skopje, Macedonia.

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Novel insights into the regulation of miRNA transcriptional control: implications for T2D and related complications.

Acta Diabetol 2018 May 7. Epub 2018 May 7.

Department of Cardiovascular and Dysmetabolic Diseases, IRCCS MultiMedica, Via Fantoli 16/15, 20138, Milan, MI, Italy.

In recent years, epigenetics has emerged as an important form of biological regulation involving chromatin control of gene expression. The mechanisms of this fine-tuned regulation are susceptible to changes forced by environmental stimuli and nutritional factors and may be potentially reversible. Dysregulation of epigenetic processes has important consequences for the pathogenesis of complex and multifactorial diseases such as type 2 diabetes (T2D) and vascular complications. Read More

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Shall we stay, or shall we switch? Continued anti-VEGF therapy versus early switch to dexamethasone implant in refractory diabetic macular edema.

Acta Diabetol 2018 May 5. Epub 2018 May 5.

Department of Ophthalmology, University Hospital Leipzig, Liebigstr. 10-14, 04103, Leipzig, Germany.

Aims: To compare functional and anatomical outcomes of continued anti-vascular endothelial growth factor (VEGF) therapy versus dexamethasone (DEX) implant in eyes with refractory diabetic macular edema (DME) after three initial anti-VEGF injections in a real-world setting.

Methods: To be included in this retrospective multicenter, case-control study, eyes were required: (1) to present with early refractory DME, as defined by visual acuity (VA) gain ≤ 5 letters or reduction in central subfield thickness (CST) ≤ 20%, after a loading phase of anti-VEGF therapy (three monthly injections) and (2) to treat further with (a) anti-VEGF therapy or (b) DEX implant. Main outcome measures were change in visual acuity (VA) and central subfield thickness (CST) at 12 months. Read More

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The post-HAPO situation with gestational diabetes: the bright and dark sides.

Acta Diabetol 2018 May 4. Epub 2018 May 4.

Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA.

Aim: In 2010, in light of the data coming from the HAPO study, the International Association of Diabetes and Pregnancy Study Groups (IADPSG) proposed a new detection strategy and diagnostic criteria for gestational diabetes based on a one-step approach with a 75 g OGTT. This review analyzes and discusses the bright and dark sides of their application.

Methods: The assessment of these recommendations by the international organizations involved in the care of gestational diabetes and a series of observational, retrospective and prospective studies that have been published since 2010 regarding the use of the IADPSG recommendations have been evaluated. Read More

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Transcutaneous oxygen pressure as a predictor for short-term survival in patients with type 2 diabetes and foot ulcers: a comparison with ankle-brachial index and toe blood pressure.

Acta Diabetol 2018 Apr 30. Epub 2018 Apr 30.

Clinical Sciences in Lund, Lund University, Lund, Sweden.

Aims: Ankle-brachial index (ABI) is the most commonly used test when diagnosing peripheral vascular disease and is considered a marker for cardiovascular risk. Transcutaneous oxygen pressure (TcPO), a test associated with microvascular function, has in several studies shown better correlation with diabetic foot ulcer (DFU) healing. Whether a low TcPO could be a marker for mortality in the high-risk population of DFU patients has not been evaluated before. Read More

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An increased waist-to-hip ratio is a key determinant of atherosclerotic burden in overweight subjects.

Acta Diabetol 2018 Jul 21;55(7):741-749. Epub 2018 Apr 21.

Cardiovascular Prevention Unit, of Metabolism and Endocrinology Service; Paris Hospital Public Assistance, Pitié-Salpêtrière Hospital Group - Pierre et Marie Curie University, Paris, France.

Aims: The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR).

Methods: We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25-29. Read More

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Ten-year comparative analysis of incidence, prognosis, and associated factors for dialysis and renal transplantation in type 1 and type 2 diabetes versus non-diabetes.

Acta Diabetol 2018 Jul 20;55(7):733-740. Epub 2018 Apr 20.

Epidemiology Unit, ASL TO3, Regione Piemonte, Grugliasco, TO, Italy.

Aims: To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM).

Methods: Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative database (Piedmont, Italy), and the crude (cumulative) incidence of dialysis was calculated. Overall cumulative survival was estimated using the Kaplan-Meier method and compared using the log-rank test. Read More

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July 2018
1 Read

Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis.

Acta Diabetol 2018 Jul 16;55(7):723-731. Epub 2018 Apr 16.

Division of Endocrinology and Diabetology, Medical Faculty, c/o German Diabetes Center, Heinrich-Heine University, Düsseldorf, Auf dem Hennekamp 65, 40225, Düsseldorf, Germany.

Aims: Infiltration of pancreatic islets with different leukocyte subtypes likely contributes to deterioration of glycemia in diabetes mellitus. Different subsets of leukocytes have been previously associated with type 1 or type 2 diabetes. This study aimed at examining these subsets at different stages of diabetes progression and possible relationships with metabolic parameters. Read More

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July 2018
1 Read

Insulin-mimetic effects of short-term rapamycin in type 1 diabetic patients prior to islet transplantation.

Acta Diabetol 2018 Jul 13;55(7):715-722. Epub 2018 Apr 13.

Endocrinology and Metabolism, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese (Milan), Italy.

Background: The immunosuppressive drug rapamycin may influence insulin sensitivity in insulin-responsive tissues.

Aims: This study aimed at evaluating the effectiveness of rapamycin pre-treatment before pancreatic islet allotransplantation (ITx) in patients with type 1 diabetes mellitus (T1DM).

Methods: Forty-one T1DM patients were studied. Read More

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July 2018
1 Read

GlyCulator2: an update on a web application for calculation of glycemic variability indices.

Acta Diabetol 2018 Apr 13. Epub 2018 Apr 13.

Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.

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April 2018
1 Read

Higher admission fasting plasma glucose levels are associated with a poorer short-term neurologic outcome in acute ischemic stroke patients with good collateral circulation.

Acta Diabetol 2018 Jul 12;55(7):703-714. Epub 2018 Apr 12.

Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3050, Australia.

Aims: In this retrospective study, we sought to delineate the collateral circulation status of acute ischemic stroke patients by CT perfusion and evaluate 90-day modified Rankin Scale (mRS) scores of patients with good or poor collaterals and its correlation with admission fasting plasma glucose (FPG).

Methods: We enrolled acute ischemic stroke patients who presented to our hospital 4.5 h within an onset of the first episode between January 2009 and December 2015. Read More

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July 2018
1 Read

Socio-demographic and clinical determinants of self-care in adults with type 2 diabetes: a multicentre observational study.

Acta Diabetol 2018 Jul 5;55(7):691-702. Epub 2018 Apr 5.

Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20099, Monza, Italy.

Aims: To describe self-care as defined by the Middle Range Theory of Self-Care of Chronic Illness and to identify clinical and socio-demographic determinants in a T2DM population.

Methods: A multicentre observational cross-sectional study was conducted involving 540 adults with a confirmed diagnosis of T2DM from six outpatient diabetes services in Italy. Socio-demographic and clinical data were collected from medical records. Read More

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July 2018
1 Read

Relationship between serum apolipoproteins levels and retinopathy risk in subjects with type 2 diabetes mellitus.

Acta Diabetol 2018 Jul 5;55(7):681-689. Epub 2018 Apr 5.

Department of Endocrinology, Shuyang People's Hospital, No. 9, Yingbin Road, Shucheng Town, Shuyang County, Suqian City, 223600, Jiangsu Province, China.

Aims: Prognostic significance of apolipoproteins in diabetic retinopathy risk has not been well investigated. The aim of this study was to reveal the relationship between the risk of diabetic retinopathy and the levels of several apolipoproteins and their ratios in a 10-year prospective cohort.

Methods: A total of 1023 diabetic patients without retinopathy were selected from a 10-year hospital-based diabetic cohort. Read More

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July 2018
3 Reads

Post-transplantation diabetes in kidney transplant recipients: an update on management and prevention.

Acta Diabetol 2018 Apr 4. Epub 2018 Apr 4.

I.R.C.C.S. Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy.

Post-transplantation diabetes mellitus (PTDM) may severely impact both short- and long-term outcomes of kidney transplant recipients in terms of graft and patient survival. However, PTDM often goes undiagnosed is underestimated or poorly managed. A diagnosis of PTDM should be delayed until the patient is on stable maintenance doses of immunosuppressive drugs, with stable kidney graft function and in the absence of acute infections. Read More

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April 2018
1 Read

The relationship between the thickness of glomerular basement membrane and renal outcomes in patients with diabetic nephropathy.

Acta Diabetol 2018 Jul 2;55(7):669-679. Epub 2018 Apr 2.

Division of Nephrology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan Province, China.

Aims: Glomerular basement membrane (GBM) thickening is considered as one of the earliest detectable pathological features of diabetic nephropathy (DN). However, whether the thickness of GBM will impact the prognosis of DN remains largely unknown. Our aim was to explore the relationship between thickness of GBM and DN progression in patients with type 2 diabetes mellitus (T2DM). Read More

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July 2018
3 Reads

Empagliflozin, metformin and insulin degludec, during pregnancy: a case report.

Acta Diabetol 2018 Jul 29;55(7):759-761. Epub 2018 Mar 29.

Department of Medicine and Aging Sciences, Aging and Translational Medicine Research Center (CeSI-Met), G. d'Annunzio University, Edificio CeSi, Room 271, Via Colle dell'Ara 1, 66100, Chieti, Italy.

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July 2018
1 Read

Sex differences in the association of psychological status with measures of physical activity and sedentary behaviour in adults with type 2 diabetes.

Acta Diabetol 2018 Jun 26;55(6):627-635. Epub 2018 Mar 26.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona and Hospital Trust of Verona, Piazzale Stefani, 1, 37126, Verona, Italy.

Aim: To assess the association of psychological variables on leisure-time physical activity and sedentary time in men and women with type 2 diabetes mellitus (T2D).

Methods: In this cross-sectional study, we evaluated 163 patients with T2D, consecutively recruited at the Diabetes Centre of the Verona General Hospital. Scores on depression and anxiety symptoms, psychosocial factors (including self-efficacy, perceived interference, perceived severity, social support, misguided support behaviour, spouse's positive behaviour), physical activity and time spent sitting were ascertained using questionnaires responses to the Beck Depression Inventory-II, Beck Anxiety Inventory, Multidimensional Diabetes Questionnaire, International Physical Activity Questionnaire. Read More

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June 2018
1 Read

Screening and diagnosis of gestational diabetes in India: a systematic review and meta-analysis.

Acta Diabetol 2018 Jun 26;55(6):613-625. Epub 2018 Mar 26.

Departments of Medicine and OB-GYN, Weill Cornell Medicine, New York, NY, USA.

Aims: Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic methods for gestational diabetes in India.

Methods: We searched MEDLINE, Embase, and POPLINE for studies on screening for GDM in India. Read More

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June 2018
2 Reads

Defining the contribution of chronic kidney disease to all-cause mortality in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study.

Acta Diabetol 2018 Jun 24;55(6):603-612. Epub 2018 Mar 24.

Department of Clinical and Molecular Medicine, "La Sapienza" University, Via di Grottarossa, 1035-1039, 00189, Rome, Italy.

Aims: To define the contribution of chronic kidney disease (CKD) to excess mortality in patients with type 2 diabetes and identify the baseline variables associated with all-cause death in those with and without CKD using the RECursive Partitioning and Amalgamation (RECPAM) method.

Methods: This observational, longitudinal, cohort study enrolled 15,773 consecutive non-dialytic patients with type 2 diabetes in 19 Diabetes Clinics throughout Italy in 2006-2008. Based on the presence of albuminuria ≥ 30 mg day and/or estimated glomerular filtration rate (eGFR) < 60 mL min·1. Read More

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June 2018
3 Reads

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo.

Acta Diabetol 2018 Jun 15;55(6):593-601. Epub 2018 Mar 15.

Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.

Aims: Diabetes is associated with an excess release of neutrophil extracellular traps (NETs) and an enhanced NETosis, a neutrophil cell death programme instrumental to anti-microbial defences, but also involved in tissue damage. We herein investigated whether the antidiabetic drug metformin protects against NETosis.

Methods: We measured NET components in the plasma of patients with pre-diabetes who were randomized to receive metformin or placebo for 2 months. Read More

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June 2018
8 Reads

Postpartum resolution of obstructive sleep apnea in women with gestational diabetes and the relationship with glucose metabolism.

Acta Diabetol 2018 Jul 15;55(7):751-754. Epub 2018 Mar 15.

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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July 2018
3 Reads

Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.

Acta Diabetol 2018 Jun 15;55(6):585-592. Epub 2018 Mar 15.

Dietmar-Hopp Metabolic Center, Center for Child and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.

Aims: 5-Aminoimidazole-4-carboxamide riboside (AICAR) is an endogenous activator of AMPK, a central regulator of energy homeostasis. Loss and/or reduction of AMPK signaling plays an important role in the development of insulin resistance in type 2 diabetes. The loss of AMPK in diabetes could be due to a loss of AICAR. Read More

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June 2018
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History of spontaneous miscarriage and the risk of diabetes mellitus among middle-aged and older Chinese women.

Acta Diabetol 2018 Jun 15;55(6):579-584. Epub 2018 Mar 15.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China.

Aims: Epidemiological studies of the long-term maternal health outcomes of spontaneous miscarriages have been sparse and inconsistent. The objective of our study is to examine the association between spontaneous miscarriages and diabetes among middle-aged and older Chinese women.

Methods: A total of 19,539 women from the Dongfeng-Tongji cohort study who completed a questionnaire and had medical examinations performed on were included in the analysis. Read More

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June 2018
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