2,013 results match your criteria Acta diabetologica[Journal]


Serum levels of immunoglobulin G and complement 3 differentiate non-diabetic renal disease from diabetic nephropathy in patients with type 2 diabetes mellitus.

Acta Diabetol 2019 Apr 19. Epub 2019 Apr 19.

Division of Nephrology, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China.

Aims: Heavy proteinuria caused by non-diabetic renal disease (NDRD) is common in type 2 diabetes mellitus (T2DM). The aim of this study was to investigate specific predictors for NDRD in addition to traditional indicators in T2DM.

Methods: A total of 341 patients with T2DM who underwent renal biopsy were retrospectively included. Read More

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http://link.springer.com/10.1007/s00592-019-01339-0
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http://dx.doi.org/10.1007/s00592-019-01339-0DOI Listing
April 2019
1 Read

Baseline neutrophil-to-lymphocyte ratio is associated with long-term T2D remission after metabolic surgery.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132, Genoa, Italy.

Aims: Metabolic surgery is considered as a therapeutic option for obese patients with type 2 diabetes (T2D). In order to identify novel laboratory variables that could improve the selection of patients who might greatly benefit from a surgical approach, we focused on the neutrophil-to-lymphocyte ratio (NLR) as a predictor of long-term T2D remission following metabolic surgery.

Methods: Thirty-one obese patients with T2D included in this pilot study underwent Roux-en-Y gastric bypass or biliopancreatic diversion (BPD) at the Surgical Department of Genoa University, IRCCS Ospedale Policlinico San Martino in Genoa (Italy). Read More

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http://dx.doi.org/10.1007/s00592-019-01345-2DOI Listing

High level of clinical inertia in insulin initiation in type 2 diabetes across Central and South-Eastern Europe: insights from SITIP study.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia.

Aims: Little is known regarding initiation of insulin therapy in type 2 diabetes (T2D) in Central and South-Eastern European countries. Therefore, we conducted a survey to characterise the prescribing practices of specialist diabetes healthcare professionals in this region and assessed factors that influence clinical decision-making regarding insulin initiation in T2D.

Methods: A cross-sectional survey sampled 211 specialist diabetes healthcare prescribers from five Central and South-Eastern European countries (Bulgaria, Croatia, Greece, Hungary, and Slovenia). Read More

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http://dx.doi.org/10.1007/s00592-019-01346-1DOI Listing
April 2019
1 Read

Effects of exenatide long-acting release on cardiovascular events and mortality in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.

Aims: Patients with type 2 diabetes (T2D) have an increased risk of cardiovascular disease. Recent cardiovascular outcome trials (CVOTs) with liraglutide, semaglutide, and albiglutide have shown significant reduction in major adverse cardiovascular events. Conversely, the CVOT with exenatide long-acting release (ELAR) confirmed cardiovascular safety of the drug, but did not reached superiority versus placebo. Read More

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http://dx.doi.org/10.1007/s00592-019-01347-0DOI Listing

Association between resting heart rate and incident diabetes risk: a Mendelian randomization study.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, 430030, Hubei, China.

Aims: Observational studies indicated that resting heart rate (RHR) was associated with diabetes mellitus (DM) risk; however, it remains unclear whether the association between RHR and DM is causal. We aimed to examine whether there was causal association of RHR with DM risk.

Methods: A prospective study including 16,201 middle-aged and older Chinese (7031 males and 9170 females) derived from the Dongfeng-Tongji cohort was performed. Read More

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http://dx.doi.org/10.1007/s00592-019-01344-3DOI Listing
April 2019
1 Read

Glucose metabolism during tumorigenesis in the genetic mouse model of pancreatic cancer.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Aim: More than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have glucose intolerance or diabetes. The association has led to two hypotheses: PDAC causes diabetes or diabetes shares risk factors for the development of PDAC. In order to elucidate the relationship between diabetes and PDAC, we investigated the glucose metabolism during tumorigenesis in the LSL-Kras; LSL-Trp53; and Pdx-1-Cre (KPC) mouse, a genetically engineered model of PDAC. Read More

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http://link.springer.com/10.1007/s00592-019-01335-4
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http://dx.doi.org/10.1007/s00592-019-01335-4DOI Listing
April 2019
2 Reads

Systematic review: associations of calcium intake, vitamin D intake, and physical activity with skeletal outcomes in people with Type 1 diabetes mellitus.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Golisano Children's Hospital, University of Rochester, 601 Elwood Ave, Box 690, Rochester, NY, 14642, USA.

Aims: The skeletal complications of type 1 diabetes (T1D) include low bone density, poor bone quality and fractures. Greater calcium intake, vitamin D intake, and physical activity are commonly recommended to improve bone health in patients with T1D. However, it is not clear whether these factors are affected by T1D or improve clinical outcomes. Read More

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http://link.springer.com/10.1007/s00592-019-01334-5
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http://dx.doi.org/10.1007/s00592-019-01334-5DOI Listing
April 2019
2 Reads

Lung function measurements in the prediabetes stage: data from the ILERVAS Project.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

Aims: Patients with type 2 diabetes have been considered a susceptible group for pulmonary dysfunction. Our aim was to assess pulmonary function on the prediabetes stage.

Methods: Pulmonary function was assessed in 4,459 non-diabetic subjects, aged between 45 and 70 years, without cardiovascular disease or chronic pulmonary obstructive disease from the ongoing study ILERVAS. Read More

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http://link.springer.com/10.1007/s00592-019-01333-6
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http://dx.doi.org/10.1007/s00592-019-01333-6DOI Listing
April 2019
3 Reads

Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes.

Acta Diabetol 2019 Apr 13. Epub 2019 Apr 13.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Borsari 46, 44121, Ferrara, Italy.

Aims: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inflammation, pathological angiogenesis, neuronal and glial dysfunction. The purinergic P2X7 receptor (P2X7R) has a leading role in inflammation and angiogenesis. Read More

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http://dx.doi.org/10.1007/s00592-019-01343-4DOI Listing

CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes.

Acta Diabetol 2019 Apr 12. Epub 2019 Apr 12.

Department of Endocrinology, Diabetes and Metabolic Disorders, Dijon University Hospital, Dijon, France.

Aim: The impact of cholesteryl ester transfer protein (CETP) on atherosclerotic development in humans remains unclear. Plasma cholesteryl ester transfer was shown to be associated with carotid intima-media thickness in type 2 diabetic (T2D) patients with adequate metabolic control. Since glycation of CETP may influence cholesteryl ester transfer processes, it is important to determine if plasma cholesteryl ester transfer is still a determinant of carotid intima-media thickness (IMT) in patients with poorly controlled diabetes. Read More

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http://dx.doi.org/10.1007/s00592-019-01340-7DOI Listing

Extreme hyperosmolarity and severe ketoacidosis in a child with type 1 diabetes mellitus at onset safely treated with current guidelines.

Acta Diabetol 2019 Apr 9. Epub 2019 Apr 9.

Azienda Ospedaliero-Universitaria of Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.

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http://dx.doi.org/10.1007/s00592-019-01336-3DOI Listing

Functional characterization of p.Pro409His variant in HNF1A, a hypomorphic mutation involved in pancreatic β-cell dysfunction.

Acta Diabetol 2019 Apr 9. Epub 2019 Apr 9.

Unit of Medical Genetics, University Hospital Mater Domini, Viale T. Campanella, 115, Catanzaro, Italy.

Aims: HNF1A is a gene coding for the transcription factor HNF1-α, mutated in some forms of MODY and type 2 diabetes mellitus characterized by a strong genetic component. The penetrance of HNF1A variants differs considerably; thus, to assess the genetic risk of diabetes in carrier subjects of a HNF1A mutant allele, a functional characterization of mutant forms is of paramount importance.

Methods: The HNF1A gene was sequenced in two patients with partly discordant diabetic phenotype, carrying the p. Read More

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http://dx.doi.org/10.1007/s00592-019-01298-6DOI Listing

Diabetes management and treatment approaches outside of North America and West Europe in 2006 and 2015.

Acta Diabetol 2019 Apr 8. Epub 2019 Apr 8.

Baker Heart and Diabetes Institute, Level 4, Alfred Centre, 99 Commercial Road, Melbourne, VIC, 3004, Australia.

Aims: The impact of introducing new classes of glucose-lowering medication (GLM) on diabetes management remains unclear, especially outside North America and Western Europe. Therefore, we aimed to analyse trends in glycaemic control and the usage of new and old GLMs in people with type 2 diabetes from 2006 to 2015.

Methods: Summary data from clinical services from nine countries outside North America and Western Europe were collected and pooled for statistical analysis. Read More

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http://dx.doi.org/10.1007/s00592-018-01284-4DOI Listing
April 2019
1 Read
2.399 Impact Factor

Analysis of S100A12 plasma levels in hyperlipidemic subjects with or without familial hypercholesterolemia.

Acta Diabetol 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical and Experimental Medicine, Internal Medicine, Garibaldi Hospital, University of Catania, Via Palermo, 636 95122, Catania, Italy.

Aims: Inflammation is a key regulatory process that links hypercholesterolemia and immune mechanisms promoting atherosclerosis. Inflammatory biomarkers may be helpful to better define the atherosclerotic burden in patients with high cholesterol levels such as familial hypercholesterolemia (FH). Our aim was to evaluate the concentration of S100A12 protein in FH patients and its association with pulse wave velocity (PWV). Read More

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http://dx.doi.org/10.1007/s00592-019-01338-1DOI Listing
April 2019
1 Read

Correction to: Agonistic autoantibodies against adrenergic receptors correlating with antihypertensive therapy in long-standing diabetes type 2.

Acta Diabetol 2019 Apr 8. Epub 2019 Apr 8.

Department of Internal Medicine III, Jena University Hospital, Jena, Germany.

Unfortunately, the Conflict of interest statement was found incomplete in the original publication and now revised by the authors. The updated version is provided here. Read More

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http://dx.doi.org/10.1007/s00592-019-01330-9DOI Listing

Accuracy of the C-glucose breath test to identify insulin resistance in non-diabetic adults.

Acta Diabetol 2019 Apr 6. Epub 2019 Apr 6.

Unidad de Investigación Médica en Nutrición, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, 06720, México City, Mexico.

Aims: To assess the validity of the C-glucose breath test (C-GBT) to identify insulin resistance (IR) in non-diabetic individuals, using hyperinsulinemic-euglycemic clamps as gold standard. This validity was compared with that of other IR surrogates.

Methodology: Non-diabetic adults were studied in a cross-sectional design. Read More

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http://dx.doi.org/10.1007/s00592-019-01318-5DOI Listing
April 2019
1 Read

Clinical practice of diabetic pregnancy screening in Asia-Pacific Countries: a survey review.

Acta Diabetol 2019 Apr 6. Epub 2019 Apr 6.

Division of O&G, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

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http://dx.doi.org/10.1007/s00592-019-01331-8DOI Listing
April 2019
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Maternal diabetes mellitus and risk of neonatal respiratory distress syndrome: a meta-analysis.

Acta Diabetol 2019 Apr 6. Epub 2019 Apr 6.

Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 38 Dengzhou Road, Qingdao, Shandong, 266021, China.

Aim: The relationship between maternal diabetes mellitus (DM) and neonatal respiratory distress syndrome (RDS) has long been recognized, but the conclusions of this relationship were non-consistent. We conducted this meta-analysis to explore the association between maternal DM and the risk of neonatal RDS.

Methods: We searched PubMed and Web of Science databases for cohort or case-control studies related to the association of maternal DM and neonatal RDS risk up to 25 August 2018. Read More

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http://dx.doi.org/10.1007/s00592-019-01327-4DOI Listing

The prevalence of methicillin-resistant Staphylococcus aureus among diabetic patients: a meta-analysis.

Acta Diabetol 2019 Apr 6. Epub 2019 Apr 6.

Division of Infection and Pathway Medicine, Edinburgh Medical School, Biomedical Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, EH16 4SB, Edinburgh, UK.

Aims: Diabetic patients have multiple risk factors for colonisation with methicillin-resistant Staphylococcus aureus (MRSA), a nosocomial pathogen associated with significant morbidity and mortality. This meta-analysis was conducted to estimate the prevalence of MRSA among diabetic patients.

Methods: The MEDLINE, Embase, BIOSIS, and Web of Science databases were searched for studies published up to May 2018 that reported primary data on the prevalence of MRSA in 10 or more diabetic patients. Read More

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http://link.springer.com/10.1007/s00592-019-01301-0
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http://dx.doi.org/10.1007/s00592-019-01301-0DOI Listing
April 2019
7 Reads

Dementia complicating type 2 diabetes and the influence of premature mortality: the Fremantle Diabetes Study.

Acta Diabetol 2019 Apr 3. Epub 2019 Apr 3.

Medical School, Fremantle Hospital, University of Western Australia, P.O. Box 480, Fremantle, WA, 6959, Australia.

Aims: To investigate risk factors for, and the influence of premature mortality on, dementia complicating type 2 diabetes.

Methods: Participants with type 2 diabetes in the community-based observational Fremantle Diabetes Study Phase 1 (n = 1291, mean age 64.0 years) were followed from 1993 to 1996 to end-June 2012. Read More

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http://dx.doi.org/10.1007/s00592-019-01322-9DOI Listing
April 2019
4 Reads

Continuous subcutaneous insulin infusion vs modern multiple injection regimens in type 1 diabetes: an updated meta-analysis of randomized clinical trials.

Acta Diabetol 2019 Apr 3. Epub 2019 Apr 3.

Department of Diabetology, Careggi Hospital, Florence, Italy.

Meta-analyses of clinical trials comparing CSII with traditional insulin injections usually show a small, but significant advantage of CSII with respect to HbA1c and risk of severe hypoglycemia. On the other hand, CSII is associated with a small, but relevant risk of ketoacidosis, mainly due to malfunction of insulin pump and/or catheter occlusion. During last time, the technology of insulin pumps and infusion sets has improved as the profound evolution in type and schemes with traditional insulin injections. Read More

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http://dx.doi.org/10.1007/s00592-019-01326-5DOI Listing

FreeStyle Libre flash glucose monitoring system in pregnant woman with type 1 diabetes: a focus on accuracy.

Acta Diabetol 2019 Apr 1. Epub 2019 Apr 1.

Division of Metabolic Diseases, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.

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http://dx.doi.org/10.1007/s00592-019-01325-6DOI Listing
April 2019
2 Reads

Hypoglycemia and hyperglycemia are risk factors for falls in the hospital population.

Acta Diabetol 2019 Mar 30. Epub 2019 Mar 30.

Departmental Unit Diabetes and Metabolic Disorders, ASST Santi Paolo e Carlo, Milan, Italy.

Objective: To determine the role of hypoglycemia, hyperglycemia or the combination of both as independent risk factors for falls in a hospital population. Secondary objectives included evaluation of other risk factors for falling and their relationships with glucose levels.

Research Design And Methods: Retrospective cohort study over 2 years on hospitalized subjects (N = 57411) analyzing in-hospital-falls and capillary glucose values. Read More

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http://dx.doi.org/10.1007/s00592-019-01323-8DOI Listing

Dietary protein intake and subsequent risk of type 2 diabetes: a dose-response meta-analysis of prospective cohort studies.

Acta Diabetol 2019 Mar 30. Epub 2019 Mar 30.

Functional Department, Foshan Hospital of TCM, No.6 Qinren Road, Chancheng District, Foshan, 528000, China.

Aims: Dietary proteins, including those obtained from animal and plant sources, have inconsistently been correlated with type 2 diabetes mellitus (T2DM) risk. Therefore, a meta-analysis was conducted to evaluate the association between dietary proteins and the risk of T2DM.

Methods: Prospective cohort studies published until November 2018 were systematically searched in PubMed, Embase, and the Cochrane library. Read More

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http://dx.doi.org/10.1007/s00592-019-01320-xDOI Listing

Therapeutic options in a patient with MELAS and diabetes mellitus: follow-up after 6 months of treatment.

Acta Diabetol 2019 Mar 29. Epub 2019 Mar 29.

Diabetology, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.

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http://dx.doi.org/10.1007/s00592-019-01302-zDOI Listing

Associations of BMI, waist circumference, body fat, and skeletal muscle with type 2 diabetes in adults.

Acta Diabetol 2019 Mar 29. Epub 2019 Mar 29.

Department of Nutrition, School of Medicine, University of Glasgow, Glasgow, UK.

Aims: Type 2 diabetes (T2D) is known to be associated with high BMI and waist circumference (WC). These measures do not discriminate well between skeletal muscle (SM) and body fat (BF), which may have opposite influences.

Methods: We conducted a secondary analysis of population-based data from 58,128 aged 18-85 yrs from Scottish Health Surveys (2003, 2008-2011) and Health Surveys for England (2003-2006, 2008-2013), excluding pregnant women and insulin-treated diabetes. Read More

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http://dx.doi.org/10.1007/s00592-019-01328-3DOI Listing

Identification of clinical predictors of diabetic nephropathy and non-diabetic renal disease in Chinese patients with type 2 diabetes, with reference to disease course and outcome.

Acta Diabetol 2019 Mar 29. Epub 2019 Mar 29.

Division of Nephrology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.

Aims: To determine the prevalence of diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) in patients with type 2 diabetes mellitus (T2DM), and the important clinical predictors of renal outcome and clinical course.

Methods: We conducted a retrospective analysis of clinical, laboratory, and histopathologic data from T2DM patients with renal involvement confirmed by renal biopsy (n = 505). The outcome was defined as the progression to end-stage renal disease (ESRD). Read More

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http://dx.doi.org/10.1007/s00592-019-01324-7DOI Listing
March 2019
2 Reads
2.399 Impact Factor

DPP-4 inhibitors: meeting the needs of the very old population.

Acta Diabetol 2019 Mar 28. Epub 2019 Mar 28.

Geriatric Unit, Section of Gerontology and Geriatrics, Department of Medicine, Santa Maria della Misericordia Hospital Perugia, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.

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http://dx.doi.org/10.1007/s00592-019-01329-2DOI Listing

Comprehensive analysis of vitreous humor chemokines in type 2 diabetic patients with and without diabetic retinopathy.

Acta Diabetol 2019 Mar 25. Epub 2019 Mar 25.

Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Yuexiu District, Guangzhou, Guangdong, China.

Aims: To compare the vitreous levels of chemokines in diabetic patients with and without retinopathy. To find the relationship between stages of diabetic retinopathy (DR) and levels of vitreous chemokines.

Methods: The study involved 20 non-diabetic and 20 diabetic patients without clinical signs of DR (NDR) and 40 diabetic patients with proliferative diabetic retinopathy (PDR). Read More

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http://dx.doi.org/10.1007/s00592-019-01317-6DOI Listing
March 2019
1 Read

Our second genome and the impact on metabolic disorders: why gut microbiome is an important player in diabetes and associated abnormalities.

Authors:
Massimo Federici

Acta Diabetol 2019 May 25;56(5):491-492. Epub 2019 Mar 25.

Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.

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http://link.springer.com/10.1007/s00592-019-01315-8
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http://dx.doi.org/10.1007/s00592-019-01315-8DOI Listing
May 2019
2 Reads

Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles.

Acta Diabetol 2019 May 22;56(5):493-500. Epub 2019 Mar 22.

Division of Systems and Digestive Medicine, Department of Surgery and Cancer, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.

The human gut is a home for more than 100 trillion bacteria, far more than all other microbial populations resident on the body's surface. The human gut microbiome is considered as a microbial organ symbiotically operating within the host. It is a collection of different cell lineages that are capable of communicating with each other and the host and has an ability to undergo self-replication for its repair and maintenance. Read More

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http://link.springer.com/10.1007/s00592-019-01312-x
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http://dx.doi.org/10.1007/s00592-019-01312-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451719PMC
May 2019
6 Reads
2.399 Impact Factor

Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study.

Acta Diabetol 2019 Mar 22. Epub 2019 Mar 22.

Department of Ophthalmology, University Hospital Leipzig, Liebigstr. 10-14, 04103, Leipzig, Germany.

Aims: To describe and compare the functional and anatomical outcomes of untreated and treated diabetic macular edema (DME) in eyes with very good baseline visual acuity (VA) in a real-world setting.

Methods: A 12-month, retrospective, multicenter, observational cohort study, including DME patients with baseline visual acuity (VA) ≤ 0.1 logMAR (≥ 20/25 Snellen) and central subfield thickness (CST) > 250 µm with intra- and/or subretinal fluid seen on optical coherence tomography. Read More

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http://dx.doi.org/10.1007/s00592-019-01310-zDOI Listing

The prevalence of comorbid depression in patients with type 2 diabetes: an updated systematic review and meta-analysis on huge number of observational studies.

Acta Diabetol 2019 Mar 22. Epub 2019 Mar 22.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Aims: Depression is a common co-morbidity in patients with type 2 diabetes mellitus (T2DM). Untreated depression in these patients adversely affects self-care activities and other diabetes complications. The aim of this study is to estimate the prevalence of depression among patients with T2DM by conducting a meta-analysis of observational studies. Read More

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http://link.springer.com/10.1007/s00592-019-01295-9
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http://dx.doi.org/10.1007/s00592-019-01295-9DOI Listing
March 2019
3 Reads

Physical activity and risk of diabetic retinopathy: a systematic review and meta-analysis.

Acta Diabetol 2019 Mar 21. Epub 2019 Mar 21.

Department of Ophthalmology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, People's Republic of China.

Aims: Diabetic retinopathy (DR) is an important microvascular complication of diabetes mellitus (DM) and a leading cause of visual impairment and blindness among people of working age. Physical activity (PA) or exercise is critical and beneficial for DM patients, whereas studies evaluating the relationship between PA and DR have yielded inconsistent and inconclusive results. The American Diabetes Association's "Standards of Medical Care in Diabetes" has also pointed out the indeterminate roles of PA in DR prevention. Read More

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http://dx.doi.org/10.1007/s00592-019-01319-4DOI Listing
March 2019
1 Read

Association of fasting glucose and glycated hemoglobin with the long-term risk of incident metabolic syndrome: Korean Genome and Epidemiology Study (KoGES).

Acta Diabetol 2019 May 21;56(5):551-559. Epub 2019 Mar 21.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital,, Sungkyunkwan University School of Medicine, 78 Saemunan-gil, Jongro-Gu, Seoul, 110-746, Republic of Korea.

Aims: Previous studies have proposed potential benefit of glycated hemoglobin (HbA1c) supplementary to fasting glucose in detecting metabolic syndrome (MetS). This study was to investigate an association of incident MetS with levels of HbA1c and fasting glucose.

Methods: In a cohort of Korean Genome and Epidemiology Study, 5515 non-diabetic adults were grouped by the levels of baseline fasting glucose and HbA1c, and followed-up for 10 years. Read More

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http://dx.doi.org/10.1007/s00592-019-01290-0DOI Listing

Normoglycaemic control with a selfmade fully closed-loop insulin delivery system during emergency surgery: an extemporaneous stress test.

Acta Diabetol 2019 Mar 21. Epub 2019 Mar 21.

WeAreNotWaiting / User of closed loop with AndroidAPS, Corneliusstr. 2a, 32791, Lage, Germany.

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http://link.springer.com/10.1007/s00592-019-01321-w
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http://dx.doi.org/10.1007/s00592-019-01321-wDOI Listing
March 2019
4 Reads

Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition.

Acta Diabetol 2019 May 19;56(5):569-579. Epub 2019 Mar 19.

Department of Diabetes, Endocrinology and Nutrition, Hospital of Girona "Dr Josep Trueta", Institut d'Investigació Biomèdica de Girona (IDIBGI), Avinguda de França s/n, 17007, Girona, Spain.

Aims: To investigate the interactions among fecal and plasma glutamate levels, insulin resistance cognition and gut microbiota composition in obese and non-obese subjects.

Methods: Gut microbiota composition (shotgun) and plasma and fecal glutamate, glutamine and acetate (NMR) were analyzed in a pilot study of obese and non-obese subjects (n = 35). Neuropsychological tests [Trail making test A (TMT-A) and Trail making test B (TMT-B)] scores measured cognitive information about processing speed, mental flexibility and executive function. Read More

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http://dx.doi.org/10.1007/s00592-019-01313-wDOI Listing

Spousal diabetes status as a risk factor for incident type 2 diabetes: a prospective cohort study and meta-analysis.

Acta Diabetol 2019 Mar 19. Epub 2019 Mar 19.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.

Aims: It is unclear if the presence of type-2 diabetes in one spouse is associated with the development of diabetes in the other spouse. We studied the concordance of diabetes among black and white participants in the Atherosclerosis Risk in Communities (ARIC) study and summarized existing studies in a meta-analysis.

Methods: We conducted a prospective cohort analysis of ARIC data from 8077 married men and women (mean age 54 years) without diabetes at baseline (1987-1989). Read More

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http://dx.doi.org/10.1007/s00592-019-01311-yDOI Listing

Understanding the gut-kidney axis among biopsy-proven diabetic nephropathy, type 2 diabetes mellitus and healthy controls: an analysis of the gut microbiota composition.

Acta Diabetol 2019 May 19;56(5):581-592. Epub 2019 Mar 19.

Kidney Research Laboratory, Division of Nephrology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China.

Aims: Type 2 diabetes mellitus (TDM) has a rising prevalence and gut microbiota involvement is increasingly recognized. Diabetic nephropathy (DN) is a major complication of TDM. The aim of the study was to understand the gut-kidney axis by an analysis of gut microbiota composition among biopsy-proven DN, TDM without kidney disease, and healthy control. Read More

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http://dx.doi.org/10.1007/s00592-019-01316-7DOI Listing
May 2019
3 Reads

Effect of night shift work on risk of diabetes in healthy nurses in Albania.

Acta Diabetol 2019 Mar 15. Epub 2019 Mar 15.

Department of Medical Science, Catholic University of Tirana "Zoja e Këshillit të Mirë", Tirana, Albania.

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http://dx.doi.org/10.1007/s00592-019-01307-8DOI Listing

Relationship between health care insurance status, social determinants and prevalence of diabetes-related microvascular complications in patients with type 1 diabetes: a nationwide survey in Brazil.

Acta Diabetol 2019 Mar 13. Epub 2019 Mar 13.

Bauru's Diabetics Association, Rua Saint Martin 27-07, Bauru, São Paulo, CEP 17012-433, Brazil.

Aims: To evaluate the relationship between social determinants, health care insurance status and occurrence of diabetes-related chronic complications (DRCC) in Brazilian patients with type 1 diabetes.

Methods: A multicenter cross-sectional study conducted between August 2011 and August 2014 in 14 public clinics in 10 Brazilian cities. Data were obtained from 1760 patients, aged 29. Read More

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http://dx.doi.org/10.1007/s00592-019-01308-7DOI Listing
March 2019
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Oral glucose effectiveness and metabolic risk in obese children and adolescents.

Acta Diabetol 2019 Mar 13. Epub 2019 Mar 13.

Research Unit for Multifactorial Diseases, Bambino Gesù Children's Hospital, Rome, Italy.

Aim: To investigate whether GE is affected in children/adolescents with obesity and abnormalities of the metabolic syndrome (MetS).

Methods: Cross-sectional study of oral GE (oGE), insulin sensitivity and secretion (calculated on 5 time-points oral glucose tolerance test) and metabolic abnormalities in 1012 patients with overweight/obesity (aged 6.0-17. Read More

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http://link.springer.com/10.1007/s00592-019-01303-y
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http://dx.doi.org/10.1007/s00592-019-01303-yDOI Listing
March 2019
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Hyperinsulinemia impairs functions of circulating endothelial progenitor cells.

Acta Diabetol 2019 Mar 11. Epub 2019 Mar 11.

Department of Cardiology, The First Hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei, China.

Aims: Circulating endothelial progenitor cells (EPCs) play a key role in maintaining endothelial function. Dysfunction of EPCs is associated with the cardiovascular complication of diabetes. The purpose of this study is to investigate the direct effects of hyperinsulinemia on EPCs and the underlying mechanisms. Read More

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http://dx.doi.org/10.1007/s00592-019-01314-9DOI Listing
March 2019
2.399 Impact Factor

The STOP DIABETES study: when prevention works.

Acta Diabetol 2019 May 2;56(5):501-504. Epub 2019 Mar 2.

First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy.

Although many drugs are now available, a large effort is still needed to prevent diabetes. The STOP DIABETES study evaluated individuals at risk for type 2 diabetes (T2D) by a 2-h 75-g oral glucose tolerance test (OGTT). Based on the three main defective physiological responses, subjects were stratified as at low, intermediate, or high risk, and treated accordingly with lifestyle modifications and drugs. Read More

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http://dx.doi.org/10.1007/s00592-019-01309-6DOI Listing
May 2019
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Efficacy of vitrectomy combined with an intraoperative dexamethasone implant in refractory diabetic macular edema.

Acta Diabetol 2019 Mar 1. Epub 2019 Mar 1.

Department of Ophthalmology, Konyang University College of Medicine, Daejeon, South Korea.

Aims: To evaluate the safety and efficacy of vitrectomy combined with an intraoperative dexamethasone (Ozurdex) implant in refractory diabetic macular edema (DME).

Methods: Patients who were diagnosed at our institution as having DME refractory to more than 6 months of non-surgical treatment and underwent intravitreal dexamethasone implantation combined with vitrectomy. All patients were followed up for more than 12 months. Read More

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http://dx.doi.org/10.1007/s00592-019-01305-wDOI Listing

Cross-talk between fetal membranes and visceral adipose tissue involves HMGB1-RAGE and VIP-VPAC2 pathways in human gestational diabetes mellitus.

Acta Diabetol 2019 Feb 28. Epub 2019 Feb 28.

Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

Aims: Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy. Maternal adipose tissue and fetal membranes secrete various molecules that are relevant players in the pathogenesis of GDM. This pilot study aimed to examine whether the expression of the high mobility group box 1 protein (HMGB1) and its receptor for advanced glycation end products (RAGE), and the vasoactive intestinal peptide (VIP) and its receptors (VPAC-1,-2) were modified in pregnant women with GDM. Read More

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http://dx.doi.org/10.1007/s00592-019-01304-xDOI Listing
February 2019
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Association of smoking and cardiometabolic parameters with albuminuria in people with type 2 diabetes mellitus: a systematic review and meta-analysis.

Acta Diabetol 2019 Feb 24. Epub 2019 Feb 24.

Diabetes Research Centre, Univerisity of Leicester, Leicester, UK.

Aims: Smoking is a strong risk factor for albuminuria in people with type 2 diabetes mellitus (T2DM). However, it is unclear whether this sequela of smoking is brought about by its action on cardiometabolic parameters or the relationship is independent. The aim of this systematic review is to explore this relationship. Read More

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http://dx.doi.org/10.1007/s00592-019-01293-xDOI Listing
February 2019

Long-term outcomes after intravitreal dexamethasone treatment in steroid responders.

Acta Diabetol 2019 Feb 24. Epub 2019 Feb 24.

LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 500 034, India.

Aims: Intravitreal steroid implants have emerged as an adjunctive therapy in diabetic macular edema (DME) in patients refractory to anti-vascular endothelial growth factor agents. However, the use of these agents in patients with a prior history of steroid-induced ocular hypertension is limited. The present study aimed to analyze long-term intraocular pressure (IOP) response to the dexamethasone implant in patients with DME and a history of steroid-induced increase in IOP. Read More

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http://dx.doi.org/10.1007/s00592-019-01299-5DOI Listing
February 2019
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