7,880 results match your criteria Acta cytologica[Journal]


Adaptation of Alpha-Papillomavirus over Millennia.

Acta Cytol 2018 Dec 13:1-3. Epub 2018 Dec 13.

Papillomaviruses (PVs) are a group of small DNA viruses that, with around 350 million years of evolution, acquired the capacity of infecting a broad range of vertebrates, including humans. To date, more than 300 PV types have been isolated. Viruses that have a long common evolutionary history with their host typically cause unapparent infections. Read More

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https://www.karger.com/Article/FullText/492658
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http://dx.doi.org/10.1159/000492658DOI Listing
December 2018
3 Reads

Subcutaneous Fat Necrosis of the Newborn: Is Fine Needle Aspiration Cytology Diagnostic?

Acta Cytol 2018 Dec 13:1-3. Epub 2018 Dec 13.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.

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http://dx.doi.org/10.1159/000494501DOI Listing
December 2018
1 Read

Correlation of Ultrasound Findings and Fine-Needle Aspiration Cytology for the Diagnosis of Axillary Lymph Node Metastasis in Patients with Breast Carcinoma.

Acta Cytol 2018 Dec 5:1-6. Epub 2018 Dec 5.

Department of Cytology, Kuwait Cancer Control Center, Safat, Kuwait.

Objective: Ultrasound-guided fine-needle aspiration cytology (USG-FNAC) is used for the detection of axillary lymph node (ALN) metastasis in patients with breast carcinoma (BC). US findings have a good diagnostic accuracy with high sensitivity and specificity. The aim of this study is to correlate the detection of ALN metastases on US with FNAC in BC patients. Read More

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https://www.karger.com/Article/FullText/493635
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http://dx.doi.org/10.1159/000493635DOI Listing
December 2018
5 Reads

Three-Tiered versus Two-Tiered Classification of Squamous Dysplasia in Cervical Cytology: Results of a Follow-Up Study.

Acta Cytol 2018 Dec 5:1-6. Epub 2018 Dec 5.

Institut für Biometrie und Klinische Epidemiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objective: Regarding cytological findings of squamous dysplasia, a comparison was made between a three-tiered classification - low-grade squamous intraepithelial lesion (LSIL), high-grade SIL/cervical intraepithelial neoplasia 2 (HSIL/CIN2), and HSIL/CIN3 - and a two-tiered classification - LSIL and HSIL. The respective risk for CIN2+ and CIN3+ was calculated to make decisions regarding management.

Methods: A total of 2,949 women with first-time cytologic findings of squamous dysplasia (LSIL, HSIL/CIN2, or HSIL/CIN3) between January 2013 and June 2016 were enrolled. Read More

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http://dx.doi.org/10.1159/000494984DOI Listing
December 2018
2 Reads

Retinal Anlage Tumor of Epididymis: A Diagnostic Challenge on Cytology.

Acta Cytol 2018 Nov 19:1-2. Epub 2018 Nov 19.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.

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http://dx.doi.org/10.1159/000494124DOI Listing
November 2018

BRAF V600 Mutational Status in Melanoma Correlates with Cytologic Features in Fine-Needle Aspirate Specimens.

Acta Cytol 2018 Nov 5:1-7. Epub 2018 Nov 5.

Melanomas are known as the great mimicker and must be considered in the differential diagnosis of any fine-needle aspirations (FNA). Despite recent advancements in understanding of the mutational landscape of melanomas, there still exists a divide between the genetic and morphologic correlates. A consecutive cohort of 39 FNA of clinically verified metastatic melanomas with concurrent BRAF V600 assessment were selected [positive (n = 18) and wild-type (n = 21)]. Read More

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http://dx.doi.org/10.1159/000491814DOI Listing
November 2018
4 Reads

Publisher's Note.

Authors:

Acta Cytol 2018 1;62(5-6):317. Epub 2018 Nov 1.

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http://dx.doi.org/10.1159/000494865DOI Listing
November 2018
1 Read

Diagnostic Accuracy of Fine-Needle Aspiration Cytology for Discrimination of Squamous Cell Carcinoma from Adenocarcinoma in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.

Acta Cytol 2018 31;62(5-6):318-326. Epub 2018 Oct 31.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, USA.

Objective: To determine the accuracy with which morphology alone can distinguish adenocarcinoma and squamous cell carcinoma in non-small cell lung cancer.

Methods: We performed a systematic review and meta-analysis. Three data bases (MEDLINE, EMBASE, Scopus) were searched for studies on the diagnostic accuracy of subtyping non-small cell lung cancer. Read More

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https://www.karger.com/Article/FullText/493942
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http://dx.doi.org/10.1159/000493942DOI Listing
October 2018
2 Reads

Cytomorphologic, Imaging, Molecular Findings, and Outcome in Thyroid Follicular Lesion of Undetermined Significance/Atypical Cell of Undetermined Significance (AUS/FLUS): A Mini-Review.

Acta Cytol 2018 Oct 31:1-9. Epub 2018 Oct 31.

Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Objectives: Since the introduction of the entity of "Atypical cell of undetermined significance /follicular lesion of undetermined significance" (AUS/FLUS) by The Bethesda System for Reporting Thyroid Cytology (TBSRTC) in 2007, there have been many published studies about the cytomorphologic criteria, subclassification, outcome, and management of patients with the diagnosis of AUS/FLUS. There have been many studies in different aspects of this indeterminate category, i.e. Read More

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https://www.karger.com/Article/FullText/493908
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http://dx.doi.org/10.1159/000493908DOI Listing
October 2018
4 Reads

The Differential Diagnosis in Nonlymphoproliferative Malignant Pleural Effusion Cytopathology and Its Correlation with Patients' Demographics.

Acta Cytol 2018 31;62(5-6):436-442. Epub 2018 Oct 31.

Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Background: We report our experience with malignant pleural effusion (MPE) and the impact of patients' demographics on the differential diagnosis at the primary site.

Methods: After IRB approval, we searched our pathology database from January 2013 to January 2017 for patients with positive pleural effusions (PEs). Patients' demographics and clinical histories were noted. Read More

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http://dx.doi.org/10.1159/000493336DOI Listing
October 2018
5 Reads

Reliability of Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Expression on Breast Cancer Cells Stored in Cellprep® Vials.

Acta Cytol 2018 31;62(5-6):360-370. Epub 2018 Oct 31.

Department of Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan.

Objective: The aim of this study was to evaluate the reliability of estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) expression levels in Cellprep® (CP).

Study Design: We evaluated the stability of immunocytochemistry (ICC) of ER and HER2 for primary or recurrent breast cancer samples rinsed in CP vials. Samples were prepared from CP vials stored for 1-30 or 160-240 days. Read More

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http://dx.doi.org/10.1159/000492501DOI Listing
October 2018
1 Read

Cytological Findings in Benign Phyllodes Tumors.

Acta Cytol 2018 Oct 26:1-5. Epub 2018 Oct 26.

Objective: Phyllodes tumors are fibroepithelial breast lesions with many cytological and histopathological similarities to fibroadenomas. The aim of this study was to investigate cytological findings in benign phyllodes tumors.

Study Design: Seventy-six histologically proven cases of benign phyllodes tumors were selected from 1982 to 2017. Read More

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http://dx.doi.org/10.1159/000493677DOI Listing
October 2018
1 Read

Eco-Pap: The Ecological Modification of the Papanicolaou Stain for Sustainable Cervical Cancer Diagnosis.

Acta Cytol 2018 Oct 23:1-9. Epub 2018 Oct 23.

Department of Pathology, Hospital Nacional Docente Madre-Niño San Bartolomé, Lima, Peru.

Objectives: To validate the ecological modification of the Papanicolaou stain (Eco-Pap) for the diagnosis of cervical cancer.

Study Design: A prospective study was performed at the Mother and Child "San Bartolomé" Hospital, Lima, Peru. Reagent handling strategies were divided into three phases: we used (1) Harris progressive hematoxylin (for nuclear staining), (2) a polychromatic solution (a mix of EA-36/Orange G-6 to suppress the use of several alcohol baths), and (3) direct mounting (with Entellan® solution). Read More

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http://dx.doi.org/10.1159/000493113DOI Listing
October 2018

Cytologic Features of SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Comparison with Other SWI/SNF Complex-Deficient Tumors.

Acta Cytol 2018 4;62(5-6):456-462. Epub 2018 Oct 4.

Division of Molecular Pathology, Faculty of Medicine, Tottori University, Yonago,

Background: SMARCA4-deficient thoracic sarcoma is a recently proposed entity of soft tissue tumors associated with an extremely poor prognosis. Its cytologic features have not been well described in the literature yet.

Case: A woman in her early 30s who presented with chest pain was found to have a tumor in the right chest wall. Read More

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http://dx.doi.org/10.1159/000493335DOI Listing
October 2018

Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors.

Acta Cytol 2018 25;62(5-6):371-379. Epub 2018 Sep 25.

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Objectives: Solid variant of papillary thyroid carcinoma (SVPTC) is rare, differing from classical PTC (cPTC) in architecture and outcome. We evaluated the cytomorphology of SVPTC cases to assess the feasibility of a preoperative diagnosis.

Study Design: SVPTC cases were evaluated for architecture, nuclear features, and Bethesda category and were compared with noninvasive follicular thyroid neoplasm with papillary-like nuclear features/follicular variant of PTC (NIFTP/FVPTC), cPTC, and poorly differentiated thyroid carcinoma (PDTC). Read More

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http://dx.doi.org/10.1159/000493081DOI Listing
September 2018
1 Read

Cytological Findings of Gastrointestinal Stromal Tumor-Derived Bone Metastasis.

Acta Cytol 2018 25;62(5-6):430-435. Epub 2018 Sep 25.

Department of Pathology, the Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.

Objective: Procedures for diagnosing bone tumors should be rapid and minimally invasive. Thus, cytological examinations are more useful for such purposes than histological examinations. In order to identify cytomorphological findings that could be used to diagnose bone metastasis from gastrointestinal stromal tumors (GIST), previous cases were reviewed. Read More

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https://www.karger.com/Article/FullText/492709
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http://dx.doi.org/10.1159/000492709DOI Listing
September 2018
13 Reads

Stromal Cellular Fragments in Breast Fine Needle Aspirates: Think Outside of the Box.

Acta Cytol 2018 24;62(5-6):450-455. Epub 2018 Sep 24.

Pathology Department, Faculdade de Medicina da Universidade do Porto, Porto,

Background: The presence of highly cellular stromal fragments in breast fine needle aspirates (FNA) suggests some classical differential diagnoses such as cellular fibroadenoma, phyllodes tumour (PT), metaplastic carcinomas, and some mesenchymal/myoepithelial proliferations. The other components of the smears can help in the differential diagnosis, but the presence of a low-grade epithelial proliferation does not always represent a fibro-epithelial lesion as we demonstrate in these two cases.

Cases: We discuss two cases of breast FNA, previously presented in a slide seminar at the 29th European Congress of Pathology in Amsterdam, where the common cytological finding was the presence of stromal cellular fragments together with an epithelial component. Read More

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https://www.karger.com/Article/FullText/492566
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http://dx.doi.org/10.1159/000492566DOI Listing
September 2018
7 Reads

Glandular Cell Abnormalities on SurePath Preparations: A Retrospective Review with Cytology-Histology Correlations.

Acta Cytol 2018 21;62(5-6):423-429. Epub 2018 Sep 21.

Objective: Detecting glandular lesions is challenging by all Pap test methodologies. As the availability of data on identifying glandular abnormalities by SurePath is scarce, we investigated the detection rates and the correlation with histology follow-up.

Study Design: A total of 105,927 cases (SurePath and conventional) were searched for the diagnosis of atypical glandular cells or higher glandular abnormalities (AGC+) with the corresponding histologic diagnosis. Read More

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http://dx.doi.org/10.1159/000493000DOI Listing
September 2018

Utility of Rapid On-Site Cytologic Evaluation during Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Malignant and Nonmalignant Disease.

Acta Cytol 2018 21;62(5-6):380-385. Epub 2018 Sep 21.

Department of Pulmonology, Geneva University Hospitals, Geneva, Switzerland.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an accurate procedure to sample mediastinal tissue. Rapid on-site cytologic evaluation (ROSE) has been advocated to improve the performance of this procedure, but its benefit remains controversial. Our objective is to assess the utility of ROSE for EBUS-TBNA diagnostic accuracy among unselected patients. Read More

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http://dx.doi.org/10.1159/000493334DOI Listing
September 2018
1 Read

Application of the Milan System for Risk Stratification and Its Comparison with a Previous Reporting System of Parotid Gland Cytopathology in a Tertiary Care Centre.

Acta Cytol 2018 17;62(5-6):352-359. Epub 2018 Sep 17.

Objective: To compare the recently proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) with the four-tiered reporting system (FTRS) followed at our institute.

Methods: Parotid gland fine-needle aspirates reported over a period of 5 years were analysed. These aspirates had been placed into 4 categories according to the FTRS: unsatisfactory (UNS), no evidence of malignancy/negative (NEG), inconclusive for malignancy (INC), and diagnostic for malignancy/positive (POS). Read More

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http://dx.doi.org/10.1159/000492051DOI Listing
September 2018

Potential Difficulties in Cytological Approach of Basal Cell Adenoma of Salivary Glands: The Experience of a Single Institution.

Acta Cytol 2018 25;62(5-6):346-351. Epub 2018 Jul 25.

Objective: Basal cell adenoma (BCA) is an uncommon benign epithelial neoplasm of salivary glands, which was first described by Kleinsasser and Klein in 1967 and which derives its name from the monomorphic basaloid appearance of tumor cells. This tumor represents 1-2% of all salivary gland epithelial tumors; the most common site of occurrence is the parotid gland. It usually arises in adults over 50 years of age with slight female prevalence. Read More

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http://dx.doi.org/10.1159/000490692DOI Listing
July 2018
8 Reads

Postmenopausal Squamous Atypia: Cytologic Features, Hybrid Capture 2 Tests and Contribution to the ASCUS Pool.

Acta Cytol 2018 25;62(5-6):418-422. Epub 2018 Jul 25.

Department of Pathology, Ohio State University Wexner Medical Center, Columbus, Ohio,

Objective: Postmenopausal squamous atypia (PSA) mimics squamous intraepithelial lesion (SIL). We investigate the PSA contribution to the atypical squamous cells of undetermined significance (ASCUS) pool, its cytologic features and Hybrid Capture 2 (HC2) relative light unit/cutoff (RLU/CO) values.

Study Design: 658 ASCUS Pap tests in women ≥55 years were reviewed to select those with koilocyte-like cells and/or atypical parakeratosis. Read More

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https://www.karger.com/Article/FullText/490691
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http://dx.doi.org/10.1159/000490691DOI Listing
July 2018
12 Reads

High-Risk Types of Human Papilloma Virus DNA Testing in Women with False Negative Cytology.

Acta Cytol 2018 13;62(5-6):411-417. Epub 2018 Jul 13.

Department of Clinical Science, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.

Objective: To determine whether high-risk types of human papilloma virus (hrHPV) DNA testing is reliable for selection patients in need of further investigation with colposcopy in women with increased risk of high-grade cervical lesions as a result of false negative cytology. The secondary objective was to compare the sensitivity of hrHPV testing on self-collected versus physician-collected samples for the detection of histological high-grade cervical intraepithelial neoplasia (CIN2+).

Methods: Sixty-three patients identified with a missed abnormality following the re-evaluation of benign cervical cytology were included. Read More

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http://dx.doi.org/10.1159/000490487DOI Listing
July 2018
13 Reads

Curious Residents of the Thyroid Gland: Two Case Reports of Colorectal Carcinoma Metastasis by Fine-Needle Aspiration Diagnosis.

Acta Cytol 2018 13;62(5-6):443-449. Epub 2018 Jul 13.

Department of Pathology, University Hospitals of Leuven, Leuven, Belgium.

Background: The most frequent metastases to the thyroid originate in the kidney, lung or breast. Colorectal adenocarcinoma represents less than 4% of metastases to the thyroid gland. Solitary metastases of colorectal cancer with no other manifestation of disseminated cancer disease are exceedingly rare. Read More

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http://dx.doi.org/10.1159/000490367DOI Listing
July 2018
4 Reads

Significance of High-Risk Human Papillomavirus Testing for Atypical Glandular Cells on Cervical Cytology.

Acta Cytol 2018 10;62(5-6):405-410. Epub 2018 Jul 10.

Objectives: The aim of this study was to evaluate the diagnostic significance of high-risk human papillomavirus (hrHPV) testing for managing women with atypical glandular cells (AGC) and to explore the distribution of hrHPV genotypes.

Methods: We analyzed cytologic and histopathologic diagnoses in patients referred to our institution due to AGC or atypical squamous cells of undetermined significance (ASC-US). All patients underwent hrHPV testing and genotyping, and positive (PPV) and negative predictive values (NPV) for cervical intraepithelial neoplasia (CIN) 2 or worse [CIN2+/adenocarcinoma in situ (AIS)+] were calculated. Read More

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http://dx.doi.org/10.1159/000490230DOI Listing
July 2018
2 Reads

Atypical Glandular Cells: Interobserver Variability according to Clinical Management.

Acta Cytol 2018 3;62(5-6):397-404. Epub 2018 Jul 3.

Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island,

Objective: The 2014 Bethesda System diagnostic criteria for atypical glandular cells (AGC) aids in classification of atypical cells in cervical cytology. There is limited literature regarding reproducibility and interobserver variability in the application of the 2014 AGC criteria. Our aim is to assess the interobserver variability of AGC with a focus on how diagnostic categories link with guideline-driven management. Read More

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http://dx.doi.org/10.1159/000489968DOI Listing
July 2018
15 Reads

Degenerated Keratinized Tumor Cells in Oropharyngeal Human Papilloma Virus-Associated Squamous Cell Carcinoma: A Pitfall in p16 Immunostaining of Fine-Needle Aspiration Specimens.

Acta Cytol 2018 2;62(5-6):339-345. Epub 2018 Jul 2.

Objective: High-risk human papilloma virus (HPV) testing should be performed on all patients with newly diagnosed oropharyngeal HPV-associated squamous cell carcinoma (OPHPVSCC), and p16 immunostaining can be used as a surrogate marker. Although in surgical pathology specimens p16 staining in > 70% of the tumor cells is considered a positive result, the interpretation in fine-needle aspiration (FNA) specimens has remained controversial.

Study Design: FNA of neck lymph nodes and corresponding surgical specimens from 42 patients with OPHPVSCC were reviewed. Read More

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http://dx.doi.org/10.1159/000490229DOI Listing
July 2018
6 Reads

Role of Field Staining in the Cytological Assessment of Intraoperative Surgical Specimens.

Acta Cytol 2018 25;62(5-6):327-332. Epub 2018 Jun 25.

Objective: To study the role of Field staining in scrape smears for intraoperative cytological (IOC) diagnosis. Specimens were assessed for categorizing among benign and malignant lesions, lymph node status, and adequacy of surgical cut margins as per specimen. Technique, adequacy, and quality were assessed along with comparison of cytological diagnosis with final histopathological diagnosis obtained on routine hematoxylin and eosin-stained slides. Read More

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http://dx.doi.org/10.1159/000489768DOI Listing
June 2018
4 Reads

Insulinoma-Associated Protein 1 Immunostain: A Diagnostic Tool for Pulmonary Small Cell Carcinoma in Cytology.

Acta Cytol 2018 22;62(5-6):333-338. Epub 2018 Jun 22.

Department of Pathology, Division of Cytopathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Objective: Cytology plays an important role in the diagnosis of small cell carcinoma (SCLC). Application of immunohistochemical (IHC) markers improves the accuracy and reproducibility of the diagnosis of SCLC. We report the application of insulinoma-associated protein 1 (INSM1) in the diagnosis of SCLC in cytology samples. Read More

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http://dx.doi.org/10.1159/000490091DOI Listing
June 2018
18 Reads

Validation of a New Low-Cost, Methanol-Based Fixative for Cervical Cytology and Human Papillomavirus Detection.

Acta Cytol 2018 18;62(5-6):393-396. Epub 2018 Jun 18.

Laboratorio Genoa/LPCM, São Paulo, Brazil.

Objective: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV).

Methods: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives. Read More

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http://dx.doi.org/10.1159/000489873DOI Listing
June 2018
2 Reads

Cell Block in Cytological Diagnostics: Review of Preparatory Techniques.

Acta Cytol 2018 15;62(4):237-243. Epub 2018 Jun 15.

Department of Pathology, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

Objective: The cell block (CB) technique refers to the processing of sediments, blood clots, or grossly visible tissue fragments from cytological specimens into paraffin blocks that can be cut and stained by the same methods used for histopathology. The technique brings additional tissue architectural information. CB can be used for ancillary techniques such as immunocytochemistry and molecular techniques. Read More

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http://dx.doi.org/10.1159/000489769DOI Listing
August 2018
18 Reads

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology.

Acta Cytol 2018 13;62(5-6):386-392. Epub 2018 Jun 13.

Department of Pathology, Federal University of Ceará, Fortaleza, Brazil.

Objective: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women.

Study Design: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. Read More

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http://dx.doi.org/10.1159/000489386DOI Listing
June 2018
2 Reads

Results of Cervical Cancer Screening in the Rural Population of Lucknow West, India, through a Camp Approach.

Acta Cytol 2018 13;62(4):273-278. Epub 2018 Jun 13.

Objective: Cytological screening was carried out in rural women of Lucknow West, India, through a camp approach to detect cervical cancer in its preinvasive phase and to see whether the primitive living conditions in the villages have any effect on the incidence of precancer and carcinoma of the cervix and the associated predisposing factors of cervical carcinogenesis.

Study Design: During a span of 4 years (May 2013 to March 2017), a total of 135 camps were organized under the auspice of Era's Lucknow Medical College and Hospital (Lucknow, India). Only 4,269 (31. Read More

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https://www.karger.com/Article/FullText/489078
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http://dx.doi.org/10.1159/000489078DOI Listing
August 2018
8 Reads

The Diagnostic Accuracy of Cytology for the Diagnosis of Hepatobiliary and Pancreatic Cancers.

Acta Cytol 2018 13;62(4):311-316. Epub 2018 Jun 13.

Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Objective: Although cytology testing is considered a valuable method to diagnose tumors that are difficult to access such as hepato-biliary-pancreatic (HBP) malignancies, its diagnostic accuracy remains unclear. We therefore aimed to investigate the diagnostic accuracy of cytology testing for HBP tumors.

Study Design: We performed a retrospective study of all cytology samples that were used to confirm radiologically detected HBP tumors between 2002 and 2016. Read More

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http://dx.doi.org/10.1159/000489549DOI Listing
August 2018
3 Reads

Evaluation of Sienna Cancer Diagnostics hTERT Antibody on 500 Consecutive Urinary Tract Specimens.

Acta Cytol 2018 6;62(4):302-310. Epub 2018 Jun 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Objectives: Telomerase activity can be detected in up to 90% of urothelial carcinomas (UC). Telomerase activity can also be detected in urinary tract cytology (UTC) specimens and indicate an increased risk of UC. We evaluated the performance of a commercially available antibody that putatively binds the telomerase reverse transcriptase (hTERT) subunit on 500 UTC specimens. Read More

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http://dx.doi.org/10.1159/000489181DOI Listing
August 2018
2 Reads

Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment.

Acta Cytol 2018 6;62(4):244-252. Epub 2018 Jun 6.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, USA.

Objective: Rapid on-site evaluation (ROSE) has been shown to improve adequacy rates and reduce needle passes. ROSE is often performed by cytopathologists who have limited availability and may be costlier than alternatives. Several recent studies examined the use of alternative evaluators (AEs) for ROSE. Read More

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http://dx.doi.org/10.1159/000489550DOI Listing
August 2018
12 Reads

Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can Cytology Face the Challenge of Diagnosis in the Light of the New Classification?

Acta Cytol 2018 1;62(4):265-272. Epub 2018 Jun 1.

Objectives: To assess the cytological findings of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), conventional papillary thyroid carcinomas (C-PTC), and invasive follicular variants of papillary thyroid carcinomas (IFV-PTC) to determine if there are cytological differences between groups.

Study Design: We have reviewed all thyroid fine-needle aspiration cytology samples diagnosed between 2000 and 2017. We have included all NIFTP cases (n = 6) and randomly selected cases of C-PTC (n = 14) and IFV-PTC (n = 8). Read More

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http://dx.doi.org/10.1159/000488579DOI Listing
August 2018
5 Reads

Evaluation of the LC-1000 Flow Cytometry Screening System for Cervical Cancer Screening in Routine Health Checkups.

Acta Cytol 2018 29;62(4):279-287. Epub 2018 May 29.

MEDIcheck LAB, Korea Association of Health Promotion, Cheongju, Republic of Korea.

Objective: This study evaluated the performance of a flow cytometry system (LC-1000) in screening cervical precancerous lesions at routine health checkups.

Study Design: In total, 928 health examinees were enrolled at 16 health promotion centers in 13 Korean cities between 2016 and 2017. All participants underwent liquid-based cervical cytology and flow cytometry testing to determine the cell proliferation index (CPIx). Read More

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http://dx.doi.org/10.1159/000489079DOI Listing
August 2018
5 Reads

Does 100% Rapid Review Improve Cervical Cancer Screening?

Acta Cytol 2018 22;62(3):209-214. Epub 2018 May 22.

Federal University of Rio Grande do Norte, Natal, Brazil.

Objective: The aim of this work was to evaluate 100% rapid review (100% RR) as a useful tool to detect false negative (FN) results.

Study Design: A sample of 8,677 swabs was investigated; the unsatisfactory and negative results were referred to 100% RR, concordant results were taken as the final diagnosis, while the discordant results were debated in a consensus meeting to reach a conclusion. The positive results were examined by 2 cytologists. Read More

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http://dx.doi.org/10.1159/000488872DOI Listing
June 2018
3 Reads

Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis?

Acta Cytol 2018 15;62(3):204-208. Epub 2018 May 15.

Background: Enlarged lymph nodes in adult patients often present a diagnostic challenge. In the absence of granuloma or necrosis, the cytology/tissue findings are misleading and relate the enlarged lymph nodes to reactive lymphoid hyperplasia (RLH), because granuloma formation is an immunological response that usually takes 14-100 days to develop. This study assesses the role of real-time (RT)-PCR in the diagnosis of the Mycobacterium complex (MTBC) in lymph node aspirates compared with culture in cases of RLH. Read More

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https://www.karger.com/Article/FullText/488871
Publisher Site
http://dx.doi.org/10.1159/000488871DOI Listing
June 2018
10 Reads

Evaluation of the HER2 and Hormone Receptor Status in Metastatic Breast Cancer Using Cell Blocks: A Multi-Institutional Study.

Acta Cytol 2018 15;62(4):288-294. Epub 2018 May 15.

Division of Clinical Biostatistics, Section of Cancer Prevention and Epidemiology, Clinical Research Center, Shikoku Cancer Center, Matsuyama, Japan.

Objective: We explore the problems associated with the cell block (CB) method for receptor analysis in breast cancer metastases and propose a method for reporting the results.

Study Design: Nine institutions used the CB method for the analysis of hormone receptors (HRs) and HER2 (human epidermal growth factor receptor 2) protein in cytological specimens of breast cancer metastases in routine practice. The stained slides were independently evaluated by 8 pathologists. Read More

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http://dx.doi.org/10.1159/000488382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159834PMC
August 2018
4 Reads

UroVysion Multi-Target Fluorescence in situ Hybridization Assay for the Detection of Malignant Bile Duct Brushing Specimens: A Comparison with Routine Cytology.

Authors:
Jing Zhai

Acta Cytol 2018 7;62(4):295-301. Epub 2018 May 7.

Objective: Routine bile duct brushing cytology is an important diagnostic tool in the evaluation of bile duct stricture. The purpose of this study was to evaluate the performance of the UroVysion fluorescence in situ hybridization (FISH) assay for the detection of malignant bile duct brushing specimens.

Study Design: Thirty-five bile duct brushing specimens were included in the study. Read More

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http://dx.doi.org/10.1159/000488636DOI Listing
August 2018
2 Reads

Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?

Acta Cytol 2018 3;62(3):193-203. Epub 2018 May 3.

Objective: We aimed to review all cytological specimens with Hürthle cells (HC) diagnosed in our institution, identify cytological features related to neoplastic (adenoma or carcinoma) and malignant histology, and discuss the role of clinicopathological findings and clinical management in these cases.

Study Design: We included 359 thyroid fine-needle aspiration cytology cases in our study. We reviewed the clinical and cytological features of surgical cases and correlated them with histological diagnosis. Read More

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http://dx.doi.org/10.1159/000488441DOI Listing
June 2018
9 Reads

Influence of the Histopathological Features of the Lesion on the Diagnostic Yield of Fine-Needle Aspiration Cytology of Pancreatic Solid Lesions.

Acta Cytol 2018 27;62(4):259-264. Epub 2018 Apr 27.

Department of Endoscopy (Endoscopic Ultrasonography Unit), Hospital Clínico Universitario San Carlos, Madrid, Spain.

Objective: The rate of pancreatic lesions has increased in recent decades due to the widespread use of advanced imaging techniques. Nowadays, a significant proportion of cases are incidentally discovered in asymptomatic patients and cytology is an important tool for the diagnosis and multidisciplinary management of these cases.

Study Design: In this study we retrospectively review the experience with pancreatic fine-needle aspiration cytology in the last 17 years at a single large tertiary hospital in Madrid, Spain. Read More

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https://www.karger.com/Article/FullText/488383
Publisher Site
http://dx.doi.org/10.1159/000488383DOI Listing
August 2018
5 Reads

Amyloidoma of Stomach: A Case Report.

Acta Cytol 2018 25;62(3):231-233. Epub 2018 Apr 25.

Department of Pathology, Hofstra Northwell School of Medicine, New Hyde Park, New York, USA.

Objective: Amyloidomas are tumor-like deposits of amyloid. Amyloidoma of the gastrointestinal tract is rare. To the best of our knowledge, this is the first instance of diagnosis of an amyloidoma in the gastrointestinal tract by fine needle aspiration (FNA). Read More

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http://dx.doi.org/10.1159/000488133DOI Listing
June 2018
2 Reads

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence.

Acta Cytol 2018 25;62(3):166-177. Epub 2018 Apr 25.

Breast Division, Cancer Institute of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.

Background: Although the association of human papillomavirus (HPV) with many cancers is well established, the involvement of HPV in breast cancer remains controversial. The purpose of this study is to perform a comprehensive review of the results and methods used to demonstrate that HPV markers are present in human breast cancer, and how well these studies fulfil the criteria for proving the viral etiology of a cancer.

Study Design: We conducted a search for molecular studies published until November 2016 that relate human breast cancer to HPV. Read More

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http://dx.doi.org/10.1159/000487700DOI Listing
June 2018
3 Reads

Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis.

Acta Cytol 2018 18;62(3):178-182. Epub 2018 Apr 18.

Department of Chest and Pulmonary Medicine, Dayanand Medical College and Hospital, Ludhiana, India.

Background: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. Read More

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http://dx.doi.org/10.1159/000488134DOI Listing
June 2018
4 Reads

Cytological Findings of Malignant and Benign Head and Neck Masses in Somalia.

Authors:
Yılmaz Baş

Acta Cytol 2018 11;62(3):183-192. Epub 2018 Apr 11.

Hitit University, Erol Olçok Education and Research Hospital, Department of Pathology, Çorum, Turkey.

Objective: There are no up-to-date records on head and neck masses (HNMs) in Somalia. This cytological study is the first to demonstrate the benefits and findings of fine-needle aspiration cytology in evaluating HNMs in the adult population of Somalia.

Study Design: A total of 116 aspiration samples were taken from different levels of the neck region, except for the thyroid. Read More

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http://dx.doi.org/10.1159/000488021DOI Listing
June 2018
4 Reads