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    7824 results match your criteria Acta cytologica[Journal]

    1 OF 157

    Assessment of the Utility of Cytology and Flow Cytometry of Cerebrospinal Fluid Samples in Clinical Practice.
    Acta Cytol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.
    Objectives: We sought to assess the utility and limitations of both flow cytometry (FC) and cytology for the analysis of cerebrospinal fluid (CSF) in a practical clinical setting.

    Methods: A total of 393 consecutive CSF samples from 171 patients submitted for both cytomorphologic and FC assessments were analyzed.

    Results: Both FC and cytology findings were negative for malignancy in 315/393 samples (80%), and either positive (POS) or suspicious/atypical (SUSP/AT) in 7% of samples. Read More

    Atypia of Undetermined Significance in Thyroid Fine-Needle Aspirations: Follow-Up and Outcome Experience in Newfoundland, Canada.
    Acta Cytol 2018 Feb 27. Epub 2018 Feb 27.
    Introduction: The rates of atypia of undetermined significance (AUS) by fine-needle aspiration (FNA) and malignant outcomes have been estimated at < 7% and 5-15%, respectively. Initial AUS diagnosis is followed up clinically with serial ultrasounds, repeat FNA, molecular testing, or direct surgery. We investigated the incidence, follow-up modalities, and final outcomes of AUS in Newfoundland. Read More

    Oral Brush Liquid-Based Cytology: A Study of Concordance between a Cytotechnologist and a Cytopathologist.
    Acta Cytol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pathology, Uttar Pradesh University of Medical Sciences, Saifai, India.
    Objective: Oral cancer accounts for almost 40% of all cancers in the Indian subcontinent. Techniques like oral scrape cytology are helpful in early diagnosis of premalignant lesion and thus prevention of malignant transformation. The purpose of this study is to evaluate the performance of cytotechnologists in assessing the adequacy and preliminary diagnostic accuracy of oral brush liquid-based cytology. Read More

    Factors that Influence Sample Adequacy in Liquid-Based Cytology after Ultrasonography-Guided Fine-Needle Aspiration of Thyroid Nodules: A Single-Center Study.
    Acta Cytol 2018 Jan 23. Epub 2018 Jan 23.
    Department of Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Republic of Korea.
    Objective: The factors that influence the acquisition of adequate samples during liquid-based cytology (LBC) remain unclear. This study aimed to identify factors that affect cytological adequacy in LBC after ultrasonography (US)-guided fine-needle aspiration (US-FNA) of thyroid nodules.

    Study Design: From January 2017 to May 2017, a single radiologist performed US-FNA to diagnose 112 thyroid nodules in 112 consecutive patients. Read More

    Application of Immunocytochemistry on Cell Block Sections for the Investigation of Thyroid Lesions.
    Acta Cytol 2018 Jan 16. Epub 2018 Jan 16.
    Second Department of Pathology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.
    Objective: To investigate the potential of Classification and Regression Trees (CARTs) for the diagnosis of thyroid lesions based on cell block immunocytochemistry and cytological outcome.

    Study Design: A total of 956 histologically confirmed cases (673 benign and 283 malignant) from patients with thyroid nodules were prepared via liquid-based cytology and evaluated; 4 additional slides were stained for cytokeratin 19 (CK-19), galectin 3 (Gal-3), Hector Battifora mesothelial cell 1 (HBME-1), and thyroglobulin. On the basis of immunocytochemistry and the cytological diagnosis, a CART algorithm was constructed and used for evaluation. Read More

    Cytologic Features of Malignant Melanoma with Osteoclast-Like Giant Cells.
    Acta Cytol 2018 Jan 13. Epub 2018 Jan 13.
    Department of Pathology, University Hospital La Princesa, Madrid, Spain.
    Background: Malignant melanoma showing numerous osteoclast-like giant cells (OGCs) is an uncommon morphologic phenomenon, rarely mentioned in the cytologic literature. The few reported cases seem to have an aggressive clinical behavior. Although most findings support monocyte/macrophage differentiation, the exact nature of OGCs is not clear. Read More

    V600E BRAF versus Non-V600E BRAF Mutated Lung Adenocarcinomas: Cytomorphology, Histology, Coexistence of Other Driver Mutations and Patient Characteristics.
    Acta Cytol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.
    Objectives: We analyzed the morphologic features and clinical characteristics of lung adenocarcinomas (ACAs) harboring mutated BRAF.

    Study Design: A review of the histology/cytology of BRAF-mutated lung ACAs was performed at the Johns Hopkins Hospital from January 1, 2013, to January 1, 2015. Patient demographics, clinical history, and ACA morphology were assessed. Read More

    Cytomorphological Findings of Follicular Dendritic Cell Sarcoma on Fine-Needle Aspiration Cytology.
    Acta Cytol 2017 Dec 23. Epub 2017 Dec 23.
    Department of Pathology, Chirayu Medical College and Hospital, Bhopal, India.
    Background: Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm arising from follicular dendritic cells of germinal centers. The most common site of origin is lymph nodes and it may mimic a variety of tumors at that location, including carcinomas and sarcomas. Diagnosis is frequently missed on cytology as there are very few case reports describing the cytological characteristics of the lesion. Read More

    Digital Applications in Cytopathology: Problems, Rationalizations, and Alternative Approaches.
    Acta Cytol 2018 29;62(1):68-76. Epub 2017 Nov 29.
    Department of Pathology, Cytopathology Section, Sidra Medicine, Qatar Foundation, Doha, Qatar.
    Objective: The aim of this work was to raise awareness of problems using digital applications for examining, teaching, and applying telecytology at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia; University of Nebraska Medical Center (UNMC), Omaha, NE, USA; and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA. The objective was to rationalize problems and propose alternative digital approaches.

    Study Design: We sought to identify solutions to improve the following: (a) interpretive examination scores at KAMC for complex cytological templates (i. Read More

    Analysis of the Cytomorphological Features in Atypical Urine Specimens following Application of The Paris System for Reporting Urinary Cytology.
    Acta Cytol 2018 18;62(1):54-61. Epub 2017 Nov 18.
    Northwell Health, Staten Island University Hospital, Department of Pathology, Staten Island, NY, USA.
    Background: This study investigates the use of The Paris System (TPS) for Reporting Urinary Cytopathology and examines the performance of individual and combined morphological features in atypical urine cytologies.

    Methods: We reviewed 118 atypical cytologies with subsequent bladder biopsies for the presence of several morphological features and reclassified them into Paris System categories. The sensitivity and specificity of individual and combined features were calculated along with the risk of malignancy. Read More

    Modified Alcohol-Formalin Cell Block Technique in Head and Neck Pathology Diagnosis.
    Acta Cytol 2018 15;62(1):39-43. Epub 2017 Nov 15.
    Department of Oral Pathology and Microbiology, KLE University's KLE VK Institute of Dental Sciences and Hospital, Belagavi, India.
    Objectives: Cell block preparation is a recognized technique in histopathological diagnosis. This technique aids in maintaining an intact architecture and reducing the diagnostic errors associated with fine-needle aspiration cytology. Numerous techniques have been put forth, but the need for an optimal technique for routine use in the laboratory still persists. Read More

    Comparison of Visual Inspection with Acetic Acid and the Pap Smear for Cervical Cancer Screening.
    Acta Cytol 2018 15;62(1):34-38. Epub 2017 Nov 15.
    Department of Obstetrics and Gynaecology, Era's Lucknow Medical College, Lucknow, India.
    Objective: To evaluate the efficacy of visual inspection with acetic acid (VIA) in the early detection of cervical cancer and compare it with the Pap smear.

    Study Design: This was a cross-sectional study conducted over a period of 3 months. A total of 316 patients who attended the Gynecology Outpatient Department of Era's Lucknow Medical College and Hospital, fulfilled the inclusion criteria, and gave their informed consent were included. Read More

    Atypical Squamous Cells in Liquid-Based Cervical Cytology: Microbiology, Inflammatory Infiltrate, and Human Papillomavirus-DNA Testing.
    Acta Cytol 2018 8;62(1):28-33. Epub 2017 Nov 8.
    Department of Pathology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
    Objective: The aim of this study was to assess the correlation between atypical squamous cells (ASC) and inflammatory infiltrate and vaginal microbiota using cervical liquid-based cytological (SurePath®) and high-risk human papillomavirus (HR-HPV) tests.

    Study Design: A cross-sectional study was conducted using a 6-year database from a laboratory in Fortaleza (Brazil). Files from 1,346 ASC cases were divided into subgroups and results concerning inflammation and vaginal microorganisms diagnosed by cytology were compared with HR-HPV test results. Read More

    Characteristics of False-Negative Thyroid Fine-Needle Aspirates.
    Acta Cytol 2018 4;62(1):12-18. Epub 2017 Nov 4.
    Department of Pathology, Baptist Hospital of Miami and Miami Cancer Institute, Miami, FL, USA.
    Introduction: False-negative thyroid fine-needle aspirates (FNA) are not well characterized.

    Methods: We correlated the results of all thyroid aspirations from 1997 to 2016 with histologic follow-up.

    Results: There were 13,733 aspirates, 2,112 (15. Read More

    High-Grade Urothelial Carcinoma on Urine Cytology Resembling Umbrella Cells.
    Acta Cytol 2018 11;62(1):62-67. Epub 2017 Nov 11.
    Department of Pathology, Baptist Hospital of Miami and Miami Cancer Institute, Miami, FL, USA.
    Context: High-grade urothelial carcinoma (UC) cells have many appearances on urine cytology, but according to The Paris System, they can be easily distinguished from umbrella cells.

    Objective: We aimed to define the incidence and appearance of high-grade UC cells that resemble umbrella cells in Cytospin preparations on urine cytology.

    Results: Cytospin preparations from 331 cases with biopsy follow-up (230 benign/low-grade and 101 malignant [22 carcinoma in situ, 52 papillary, 19 invasive UC, 8 other] cases) were reviewed. Read More

    Organized Cervical Cancer Screening Program in Barretos, Brazil: Experience in 18 Municipalities of São Paulo State.
    Acta Cytol 2018 26;62(1):19-27. Epub 2017 Oct 26.
    Cancer Prevention Department, Barretos Cancer Hospital, Barretos, Brazil.
    Objectives: The aim of this report is to demonstrate the Barretos Cancer Hospital initiative of organizational, laboratorial, and human resources training in the implementation of an organized cervical screening program in low-resource settings.

    Methods: We developed a computational program to report all epidemiological, clinical, and laboratorial findings, and to trace all necessary information to recruit women for regular screening or for referral for complementary exams after liquid-based Pap test analyses.

    Results: All Pap tests were collected in liquid medium and in 2014 more than 160,000 tests were analyzed and 2,900 colposcopy examinations were performed. Read More

    Intraoperative Squash and Touch Preparation Cytology of Brain Lesions Stained with H+E and Diff-Quik™: A 20-Year Retrospective Analysis and Comparative Literature Review.
    Acta Cytol 2018 5;62(1):44-53. Epub 2017 Oct 5.
    Department of Pathology, Fukuoka University Hospital and School of Medicine, Fukuoka, Japan.
    Objective: Squash preparation (SP) is a rapid technique for the intraoperative assessment of brain lesions. Only a few studies have employed touch preparation (TP) cytology and Diff-QuikTM (DQ) staining in conjunction with SP. Our study aimed to assess the diagnostic efficacy of SP of brain lesions at our institution, ascertain the additional effect of TP and DQ staining, examine factors affecting the sensitivity and specificity of our methods, and compare our findings with those of previous investigations. Read More

    A Modified Direct-Smear Processing Technique Employing Two-Step Centrifugation/Fixation Is Useful for Detecting High-Grade Urothelial Carcinoma.
    Acta Cytol 2017 28;61(6):447-454. Epub 2017 Sep 28.
    Department of Surgical Pathology, Teikyo University, Chiba Medical Center, Ichihara, Japan.
    Objective: To demonstrate the usefulness of a direct-smear processing technique employing two-step centrifugation/fixation processing (TSCFP) in the cytoscreening of high-grade urothelial carcinoma (HGUC).

    Study Design: Using the T24 HGUC cell line, we compared the cell yield and the morphological preservation of preparations concurrently processed by direct-smear, SurePath, ThinPrep, and TSCFP techniques. A total of 287 urine cytology cases subjected to TSCFP over a period of 6 years were reviewed and reclassified according to the Paris System for Reporting Urinary Cytology (PSRUC) and correlated with histology results. Read More

    Assessment of Clinically Suspected Tubercular Lymphadenopathy by Real-Time PCR Compared to Non-Molecular Methods on Lymph Node Aspirates.
    Acta Cytol 2018 26;62(1):4-11. Epub 2017 Sep 26.
    Department of Pathology, Jawaharlal Nehru Medical College, Wardha, India.
    Background: The diagnosis of tubercular lymphadenitis (TBLN) is challenging. This study assesses the role of diagnostic intervention with real-time PCR in clinically suspected tubercular lymphadenopathy in relation to cytology and microbiological methods.

    Methods: The cross-sectional study involved 214 patients, and PCR, cytology, and Ziehl-Neelsen (ZN) staining was performed on aspirates. Read More

    Clinical Utility of Endometrial Cell Block Cytology in Postmenopausal Women.
    Acta Cytol 2017 23;61(6):441-446. Epub 2017 Aug 23.
    Department of Pathology, St. Mary's Hospital, Kurume, Japan.
    Objective: To investigate the diagnostic utility of endometrial (EM) cell block (CB) cytology for the detection of intrauterine malignancy in postmenopausal women.

    Methods: We reviewed the medical records of 104 postmenopausal women between January 2012 and November 2014. We reviewed symptoms upon admission, body mass index, parity, transvaginal ultrasonographic findings, and histopathological results based on CB and conventional cytology. Read More

    Use of Exfoliative Specimens and Fine-Needle Aspiration Smears for Mutation Testing in Lung Adenocarcinoma.
    Acta Cytol 2017 22;61(6):455-461. Epub 2017 Aug 22.
    Department of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
    Objective: Cytology specimens are considered to be a promising alternative for detecting driver mutations in lung cancer patients. We aimed to explore the suitability and utility of various cytology samples of non-small-cell lung cancer (NSCLC) patients for mutation testing. In addition to mutation detection, the importance of preanalytic factors was discussed. Read More

    Cytological Features of the Large Cell Variant of Small Cell Ovarian Carcinoma in Young Patients with Hypercalcemia: Histological Findings and Review of the Literature.
    Acta Cytol 2017 27;61(6):462-468. Epub 2017 Jul 27.
    Department of Pathology, Metaxas Memorial Cancer Hospital, Piraeus, Greece.
    Objective: To present the cytological features of a very rare and lethal ovarian neoplasm occurring in the young.

    Study Design: We reviewed the cytological findings as they presented in touch imprints obtained from an ovarian mass sent to our department for frozen section investigation.

    Results: Smears were highly cellular. Read More

    False-Negative Rate of Papanicolaou Testing: A National Survey from the Thai Society of Cytology.
    Acta Cytol 2017 25;61(6):434-440. Epub 2017 Jul 25.
    Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
    Objective: To evaluate the performance of Papanicolaou smear screening in Thailand at the national level, and to propose recommendations for continuing quality control.

    Study Design: This study was conducted by The Thai Society of Cytology and involved 124 laboratories in 76 provinces during 2010-2014. Random sampling suggested recalling of 10% of slides defined as negative at routine screenings (10% random rescreening [R10] model) directly from the reading unit. Read More

    Cytological Criteria to Distinguish Phyllodes Tumour of the Breast from Fibroadenoma.
    Acta Cytol 2017 25;61(6):418-424. Epub 2017 Jul 25.
    Division of Anatomical Pathology, School of Pathology, University of the Witwatersrand, and National Health Laboratory Service, Johannesburg, South Africa.
    Objective: To determine whether there are significant differences between fibroadenomas and phyllodes tumours with regard to selected cytomorphological features.

    Study Design: A 10-year retrospective review was performed of patients who underwent excision of a fibroadenoma or phyllodes tumour and in whom a preoperative fine-needle aspiration was performed. The following cytological criteria were assessed: number of stromal and epithelial fragments, stromal-to-epithelial ratio, stromal cellularity, stromal borders, stromal atypia, and proportion of background wavy spindled cells. Read More

    Difficulty in the Cytodiagnosis of Mammary Analogue Secretory Carcinoma: Survey of 109 Cytologists with a Case Originating from a Minor Salivary Gland.
    Acta Cytol 2017 25;61(6):469-476. Epub 2017 Jul 25.
    Department of Pathology, Saga University Hospital, Saga, Japan.
    Background: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA).

    Case: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i. Read More

    Expectations and Projections for the Future of Nongynecolgical Cytology 10 Years Ago: Did They Materialize and How Did We Do?
    Acta Cytol 2017 11;61(4-5):373-407. Epub 2017 Jul 11.
    Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
    In 2007, an article entitled "How Technology Is Reshaping the Practice of Nongynecologic Cytology: Frontiers of Cytology Symposium" [Bibbo: Acta Cytol 2007;51:123-152] was published. The moderator and editor was Marluce Bibbo, previous Editor-in-Chief of Acta Cytologica, and 17 participants from countries throughout the world were asked to answer how new technologies were being applied in their respective laboratories and whether future advances and challenges can be predicted. Ten years later, two previous participants in this Golden Anniversary Cytology Symposium were asked by Kari Syrjänen, current Editor-in-Chief of Acta Cytologica, to make a reappraisal of the 2007 predictions. Read More

    The Bethesda System for Reporting Cervical Cytology: A Historical Perspective.
    Acta Cytol 2017 11;61(4-5):359-372. Epub 2017 Jul 11.
    Department of Pathology, Northwestern University Feinberg School of Medicine and Northwestern Medicine, Chicago, IL, USA.
    The aims of The Bethesda System (TBS) were to provide effective communication from the laboratory to the clinical provider; facilitate cytologic-histologic correlation; facilitate research into the epidemiology, biology, and pathology of cervical disease; and provide reproducible and reliable data for national and international statistical analysis comparisons. Dr. Diane Solomon and colleagues' contribution to cervical cancer screening, diagnosis, and management began with the inception and dissemination of TBS for reporting cervical cytology in 1988, as detailed in the accompanying article [Solomon et al. Read More

    A Groundbreaking Work Which Laid the Foundation for Mass Screening in Cervical Cytology in Japan.
    Acta Cytol 2017 11;61(4-5):299-304. Epub 2017 Jul 11.
    International University of Health and Welfare, Graduate School, Tokyo, and Department of Diagnostic Pathology, Nippon Koukan Hospital, Kawasaki, Japan.
    This commentary discusses the impact of a milestone article on the accuracy of cervical smears for detecting cancer back in the developmental and transforming era of the cytological detection of atypical and malignant cells. The study served in the establishment of cancer screening in Japan which has contributed greatly in decreasing mortality from cervical cancers. Read More

    A Review of the Use of Fine-Needle Aspiration Biopsy of Mammary Tumors for Diagnosis and Research.
    Acta Cytol 2017 11;61(4-5):305-315. Epub 2017 Jul 11.
    Department of Pathology and Cytology, Karolinska University Hospital Solna, Stockholm, Sweden.
    The article "Aspiration Biopsy of Mammary Tumors in Diagnosis and Research - A Critical Review of 2,200 Cases" by Zajicek et al. [Acta Cytol 1967;11:169-175] is composed of two separate parts as can be seen from the title. Both are, however, of great historical interest. Read More

    Two Landmark Studies Published in 1976/1977 Paved the Way for the Recognition of Human Papillomavirus as the Major Cause of the Global Cancer Burden.
    Acta Cytol 2017 11;61(4-5):316-337. Epub 2017 Jul 11.
    Department of Clinical Research, Biohit Oyj, Helsinki, Finland; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
    Two groundbreaking reports were published in Acta Cytologica at the transition of 1976 to 1977. One appeared in the last issue of 1976 [Meisels and Fortin: Acta Cytol 1976;20:505-509] and the other in the first issue of 1977 [Purola and Savia: Acta Cytol 1977;21:26-31]. Today, 40 years later, it is not an overstatement to conclude that these are the two most influential studies ever published in this journal. Read More

    Dr. Bibbo's Presidential Address on Automation in Cytology: Were Her Predictions Right, Wrong, or Somewhere in the Middle?
    Acta Cytol 2017 11;61(4-5):345-358. Epub 2017 Jul 11.
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    In 1983, Dr. Marluce Bibbo gave the Presidential Address at the Annual Meeting of the American Society of Cytology in Denver, CO, USA. The lecture was entitled "Analytic and Quantitative Cytology," a field in which Dr. Read More

    George Papanicolaou's Efforts to Develop Novel Cytologic Methods for the Early Diagnosis of Endometrial Carcinoma.
    Acta Cytol 2017 11;61(4-5):281-298. Epub 2017 Jul 11.
    Department of Pathology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
    Toward the end of his career, Dr. George Papanicolaou became interested in human endometrial explants placed into tissue culture. The initial focus of his studies was on phagocytic cells emanating from endometrial explants and their role in cleansing the uterine cavity after each menstrual cycle and in sterilizing the uterine cavity in the face of infection. Read More

    The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia.
    Acta Cytol 2017 1;61(6):425-433. Epub 2017 Jun 1.
    Center for Research Support, Barretos Cancer Hospital, Pius XII Foundation, Barretos, Brazil.
    Objective: To compare the results of cervical cytology and high-risk HPV tests using samples obtained using two different collection modalities in a population of Brazilian women: self-collection (vaginal lavage) and cervical Pap testing.

    Methods: We enrolled 204 women who were aged 18-64 years and had previously obtained abnormal cervical cytology test results; 83.8% of them agreed to participate. Read More

    Fine-Needle Aspiration of Metastatic Central Type Primitive Neuroectodermal Tumors in Patients with a Germ Cell Tumor.
    Acta Cytol 2017 30;61(6):409-417. Epub 2017 May 30.
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
    Objective: Central type primitive neuroectodermal tumors (PNET) are some of the most frequent somatic type tumors derived from germ cell tumors and can metastasize. We studied the cytomorphological features of metastatic central type PNET by fine-needle aspiration (FNA).

    Materials And Methods: A computerized search of our laboratory information system was performed for the 9-year period from 2005 through 2014 to identify all cytology cases in which a diagnosis of metastatic central type PNET had been rendered. Read More

    Molecular Alterations in Patients with Pulmonary Adenocarcinoma Presenting with Malignant Pleural Effusion at the First Diagnosis.
    Acta Cytol 2017 25;61(3):214-222. Epub 2017 May 25.
    Division of Cytopathology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
    Objectives: The aim of this study was to report cytologic and molecular features of pulmonary adenocarcinoma patients presenting with a malignant pleural effusion at the first diagnosis.

    Study Design: Patients who had a cytopathologic diagnosis conclusive for lung adenocarcinoma for the first time on their pleural fluid specimen, and molecular testing done, were studied. The control group consisted of patients with a malignant pleural effusion that developed during disease progression. Read More

    The Significance of Glandular Cells on Conventional Cervicovaginal Smears: Experience from a Tertiary Care Hospital in Coastal India.
    Acta Cytol 2017 25;61(3):199-206. Epub 2017 May 25.
    Department of Pathology, Kasturba Medical College, Manipal University, Mangalore, India.
    Introduction: Glandular lesions of the female genital tract (FGT) are quite uncommon compared to squamous lesions. Their cytological diagnosis is difficult because of their architectural and cytological complexity, as well as the lack of experience of many cytopathologists in this field. The aim of this study was to determine the significance of Papanicolaou (Pap) smears in the diagnosis of glandular FGT lesions. Read More

    Is the Morning Sputum Sample Superior to the Fresh Sputum Sample for the Detection of Malignant Cells?
    Acta Cytol 2017 24;61(3):223-229. Epub 2017 May 24.
    Department of Cytopathology, Tata Memorial Hospital, Mumbai, India.
    Introduction: Sputum cytology is a well-established technique for the detection of lung malignancies. Generally, random or morning samples are used.

    Objectives: To evaluate the diagnostic yield of morning sputum and compare it with that of fresh samples. Read More

    Molecular Diagnosis of Tubercular Lymphadenopathy from Fine-Needle Aspirates in Pediatric Patients.
    Acta Cytol 2017 20;61(3):173-178. Epub 2017 May 20.
    Department of Pathology, Jawaharlal Nehru Medical College Sawangi, Wardha, India.
    Objectives: The diagnosis of peripheral tubercular lymphadenopathy (TBLN) in pediatric patients is often a challenge because features evident on fine-needle aspiration cytology (FNAC) or tissue biopsy can be deceptive for the reason that they result from an immunological response. This study aimed to evaluate polymerase chain reaction (PCR) for Mycobacterium tuberculosis complex (MTBC) in pediatric patients under clinical suspicion for TBLN and to assess its role in the evaluation of cases cytodiagnosed as reactive lymphoid hyperplasia.

    Methods: This was a cross-sectional study conducted on 45 pediatric patients clinically suspected and unsuspected for TBLN. Read More

    Assessment of 100% Rapid Review as an Effective Tool for Internal Quality Control in Cytopathological Services.
    Acta Cytol 2017 19;61(3):207-213. Epub 2017 May 19.
    Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
    Objective: The aim of this study was to evaluate the 100% rapid review (100%-RR) as an effective tool for internal quality control (IQC) in gynecological cytopathology services.

    Study Design: A total of 8,677 swabs were analyzed; the negative results were submitted to 100%-RR. Divergent cases were discussed in a consensus meeting to reach a conclusion on the final diagnosis. Read More

    p16/Ki-67 Immunocytochemistry in Gynecological Cytology: Limitations in Practice.
    Acta Cytol 2017 19;61(3):230-236. Epub 2017 May 19.
    Institute of Pathology, Potsdam-Bornstedt, Germany.
    Objective: Immunochemical detection of the protein p16INK4a in cervical cytology is used in combination with Ki-67. Cells positive for both proteins are certain to have been transformed by high-risk HPV. p16/Ki-67 immunocytochemistry provides a significant improvement in specificity over cytology and HPV DNA testing. Read More

    Vascular Proliferation of the Thyroid: Potential Histopathological Pitfalls as a Consequence of Fine Needle Aspiration.
    Acta Cytol 2017 18;61(3):179-186. Epub 2017 May 18.
    Department of Pathology, Fimlab Laboratories, Tampere University Hospital, and Department of Pathology, School of Medicine, Tampere University, Tampere, Finland.
    Objective: Fine needle aspiration biopsy (FNAB) can cause reactive histopathological changes, commonly including haemorrhage and granulation tissue. The literature describing vascular proliferation after FNAB is sparse. We aimed to describe neovascularisation in thyroid gland specimens as a consequence of FNAB. Read More

    Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review.
    Acta Cytol 2017 11;61(3):237-241. Epub 2017 May 11.
    Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
    Background: Adenoid cystic carcinoma (ACC) of the larynx and trachea is very rare.

    Case: A 45-year-old man with ACC of the larynx presenting as a thyroid mass is reported in this study. Physical examination revealed a large solid thyroid nodule in the left lobe without any lymphadenopathy. Read More

    Evaluating the Age Cutoff Criterion for Reporting Benign-Appearing Endometrial Cells in Routine Pap Tests: An 8-Year Retrospective Review.
    Acta Cytol 2017 10;61(3):194-198. Epub 2017 May 10.
    Department of Pathology, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
    Objective: The 2014 Bethesda System recommends that benign-appearing endometrial cells (BECs) in routine Pap tests should be reported in patients aged ≥45 years. This is a change from previous guidelines to report BECs in women ≥40 years of age. BECs are reported to have 1% chance of endometrial lesion on follow-up. Read More

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