7,857 results match your criteria Acta cytologica[Journal]


High-Risk Types of Human Papilloma Virus DNA Testing in Women with False Negative Cytology.

Acta Cytol 2018 Jul 13:1-7. Epub 2018 Jul 13.

Department of Clinical Science, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.

Objective: To determine whether high-risk types of human papilloma virus (hrHPV) DNA testing is reliable for selection patients in need of further investigation with colposcopy in women with increased risk of high-grade cervical lesions as a result of false negative cytology. The secondary objective was to compare the sensitivity of hrHPV testing on self-collected versus physician-collected samples for the detection of histological high-grade cervical intraepithelial neoplasia (CIN2+).

Methods: Sixty-three patients identified with a missed abnormality following the re-evaluation of benign cervical cytology were included. Read More

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Curious Residents of the Thyroid Gland: Two Case Reports of Colorectal Carcinoma Metastasis by Fine-Needle Aspiration Diagnosis.

Acta Cytol 2018 Jul 13:1-7. Epub 2018 Jul 13.

Department of Pathology, University Hospitals of Leuven, Leuven, Belgium.

Background: The most frequent metastases to the thyroid originate in the kidney, lung or breast. Colorectal adenocarcinoma represents less than 4% of metastases to the thyroid gland. Solitary metastases of colorectal cancer with no other manifestation of disseminated cancer disease are exceedingly rare. Read More

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Significance of High-Risk Human Papillomavirus Testing for Atypical Glandular Cells on Cervical Cytology.

Acta Cytol 2018 Jul 10:1-6. Epub 2018 Jul 10.

Objectives: The aim of this study was to evaluate the diagnostic significance of high-risk human papillomavirus (hrHPV) testing for managing women with atypical glandular cells (AGC) and to explore the distribution of hrHPV genotypes.

Methods: We analyzed cytologic and histopathologic diagnoses in patients referred to our institution due to AGC or atypical squamous cells of undetermined significance (ASC-US). All patients underwent hrHPV testing and genotyping, and positive (PPV) and negative predictive values (NPV) for cervical intraepithelial neoplasia (CIN) 2 or worse [CIN2+/adenocarcinoma in situ (AIS)+] were calculated. Read More

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Atypical Glandular Cells: Interobserver Variability according to Clinical Management.

Acta Cytol 2018 Jul 3:1-8. Epub 2018 Jul 3.

Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Objective: The 2014 Bethesda System diagnostic criteria for atypical glandular cells (AGC) aids in classification of atypical cells in cervical cytology. There is limited literature regarding reproducibility and interobserver variability in the application of the 2014 AGC criteria. Our aim is to assess the interobserver variability of AGC with a focus on how diagnostic categories link with guideline-driven management. Read More

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July 2018
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Degenerated Keratinized Tumor Cells in Oropharyngeal Human Papilloma Virus-Associated Squamous Cell Carcinoma: A Pitfall in p16 Immunostaining of Fine-Needle Aspiration Specimens.

Acta Cytol 2018 Jul 2:1-7. Epub 2018 Jul 2.

Objective: High-risk human papilloma virus (HPV) testing should be performed on all patients with newly diagnosed oropharyngeal HPV-associated squamous cell carcinoma (OPHPVSCC), and p16 immunostaining can be used as a surrogate marker. Although in surgical pathology specimens p16 staining in > 70% of the tumor cells is considered a positive result, the interpretation in fine-needle aspiration (FNA) specimens has remained controversial.

Study Design: FNA of neck lymph nodes and corresponding surgical specimens from 42 patients with OPHPVSCC were reviewed. Read More

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July 2018
1 Read

Role of Field Staining in the Cytological Assessment of Intraoperative Surgical Specimens.

Acta Cytol 2018 Jun 25:1-6. Epub 2018 Jun 25.

Objective: To study the role of Field staining in scrape smears for intraoperative cytological (IOC) diagnosis. Specimens were assessed for categorizing among benign and malignant lesions, lymph node status, and adequacy of surgical cut margins as per specimen. Technique, adequacy, and quality were assessed along with comparison of cytological diagnosis with final histopathological diagnosis obtained on routine hematoxylin and eosin-stained slides. Read More

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Insulinoma-Associated Protein 1 Immunostain: A Diagnostic Tool for Pulmonary Small Cell Carcinoma in Cytology.

Acta Cytol 2018 Jun 22:1-6. Epub 2018 Jun 22.

Department of Pathology, Division of Cytopathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Objective: Cytology plays an important role in the diagnosis of small cell carcinoma (SCLC). Application of immunohistochemical (IHC) markers improves the accuracy and reproducibility of the diagnosis of SCLC. We report the application of insulinoma-associated protein 1 (INSM1) in the diagnosis of SCLC in cytology samples. Read More

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June 2018
5 Reads

Validation of a New Low-Cost, Methanol-Based Fixative for Cervical Cytology and Human Papillomavirus Detection.

Acta Cytol 2018 Jun 18:1-4. Epub 2018 Jun 18.

Laboratorio Genoa/LPCM, São Paulo, Brazil.

Objective: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV).

Methods: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives. Read More

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Cell Block in Cytological Diagnostics: Review of Preparatory Techniques.

Acta Cytol 2018 Jun 15:1-7. Epub 2018 Jun 15.

Department of Pathology, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

Objective: The cell block (CB) technique refers to the processing of sediments, blood clots, or grossly visible tissue fragments from cytological specimens into paraffin blocks that can be cut and stained by the same methods used for histopathology. The technique brings additional tissue architectural information. CB can be used for ancillary techniques such as immunocytochemistry and molecular techniques. Read More

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June 2018
1 Read

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology.

Acta Cytol 2018 Jun 13:1-7. Epub 2018 Jun 13.

Department of Pathology, Federal University of Ceará, Fortaleza, Brazil.

Objective: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women.

Study Design: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. Read More

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Results of Cervical Cancer Screening in the Rural Population of Lucknow West, India, through a Camp Approach.

Acta Cytol 2018 Jun 13:1-6. Epub 2018 Jun 13.

Objective: Cytological screening was carried out in rural women of Lucknow West, India, through a camp approach to detect cervical cancer in its preinvasive phase and to see whether the primitive living conditions in the villages have any effect on the incidence of precancer and carcinoma of the cervix and the associated predisposing factors of cervical carcinogenesis.

Study Design: During a span of 4 years (May 2013 to March 2017), a total of 135 camps were organized under the auspice of Era's Lucknow Medical College and Hospital (Lucknow, India). Only 4,269 (31. Read More

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The Diagnostic Accuracy of Cytology for the Diagnosis of Hepatobiliary and Pancreatic Cancers.

Acta Cytol 2018 Jun 13:1-6. Epub 2018 Jun 13.

Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Objective: Although cytology testing is considered a valuable method to diagnose tumors that are difficult to access such as hepato-biliary-pancreatic (HBP) malignancies, its diagnostic accuracy remains unclear. We therefore aimed to investigate the diagnostic accuracy of cytology testing for HBP tumors.

Study Design: We performed a retrospective study of all cytology samples that were used to confirm radiologically detected HBP tumors between 2002 and 2016. Read More

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June 2018
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Evaluation of Sienna Cancer Diagnostics hTERT Antibody on 500 Consecutive Urinary Tract Specimens.

Acta Cytol 2018 Jun 6:1-9. Epub 2018 Jun 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Objectives: Telomerase activity can be detected in up to 90% of urothelial carcinomas (UC). Telomerase activity can also be detected in urinary tract cytology (UTC) specimens and indicate an increased risk of UC. We evaluated the performance of a commercially available antibody that putatively binds the telomerase reverse transcriptase (hTERT) subunit on 500 UTC specimens. Read More

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Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment.

Acta Cytol 2018 Jun 6:1-9. Epub 2018 Jun 6.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, USA.

Objective: Rapid on-site evaluation (ROSE) has been shown to improve adequacy rates and reduce needle passes. ROSE is often performed by cytopathologists who have limited availability and may be costlier than alternatives. Several recent studies examined the use of alternative evaluators (AEs) for ROSE. Read More

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June 2018
1 Read

Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can Cytology Face the Challenge of Diagnosis in the Light of the New Classification?

Acta Cytol 2018 Jun 1:1-8. Epub 2018 Jun 1.

Objectives: To assess the cytological findings of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), conventional papillary thyroid carcinomas (C-PTC), and invasive follicular variants of papillary thyroid carcinomas (IFV-PTC) to determine if there are cytological differences between groups.

Study Design: We have reviewed all thyroid fine-needle aspiration cytology samples diagnosed between 2000 and 2017. We have included all NIFTP cases (n = 6) and randomly selected cases of C-PTC (n = 14) and IFV-PTC (n = 8). Read More

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Evaluation of the LC-1000 Flow Cytometry Screening System for Cervical Cancer Screening in Routine Health Checkups.

Acta Cytol 2018 May 29:1-9. Epub 2018 May 29.

MEDIcheck LAB, Korea Association of Health Promotion, Cheongju, Republic of Korea.

Objective: This study evaluated the performance of a flow cytometry system (LC-1000) in screening cervical precancerous lesions at routine health checkups.

Study Design: In total, 928 health examinees were enrolled at 16 health promotion centers in 13 Korean cities between 2016 and 2017. All participants underwent liquid-based cervical cytology and flow cytometry testing to determine the cell proliferation index (CPIx). Read More

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Does 100% Rapid Review Improve Cervical Cancer Screening?

Acta Cytol 2018 22;62(3):209-214. Epub 2018 May 22.

Federal University of Rio Grande do Norte, Natal, Brazil.

Objective: The aim of this work was to evaluate 100% rapid review (100% RR) as a useful tool to detect false negative (FN) results.

Study Design: A sample of 8,677 swabs was investigated; the unsatisfactory and negative results were referred to 100% RR, concordant results were taken as the final diagnosis, while the discordant results were debated in a consensus meeting to reach a conclusion. The positive results were examined by 2 cytologists. Read More

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Reactive Lymphoid Hyperplasia or Tubercular Lymphadenitis: Can Real-Time PCR on Fine-Needle Aspirates Help Physicians in Concluding the Diagnosis?

Acta Cytol 2018 15;62(3):204-208. Epub 2018 May 15.

Background: Enlarged lymph nodes in adult patients often present a diagnostic challenge. In the absence of granuloma or necrosis, the cytology/tissue findings are misleading and relate the enlarged lymph nodes to reactive lymphoid hyperplasia (RLH), because granuloma formation is an immunological response that usually takes 14-100 days to develop. This study assesses the role of real-time (RT)-PCR in the diagnosis of the Mycobacterium complex (MTBC) in lymph node aspirates compared with culture in cases of RLH. Read More

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Evaluation of the HER2 and Hormone Receptor Status in Metastatic Breast Cancer Using Cell Blocks: A Multi-Institutional Study.

Acta Cytol 2018 May 15:1-7. Epub 2018 May 15.

Division of Clinical Biostatistics, Section of Cancer Prevention and Epidemiology, Clinical Research Center, Shikoku Cancer Center, Matsuyama, Japan.

Objective: We explore the problems associated with the cell block (CB) method for receptor analysis in breast cancer metastases and propose a method for reporting the results.

Study Design: Nine institutions used the CB method for the analysis of hormone receptors (HRs) and HER2 (human epidermal growth factor receptor 2) protein in cytological specimens of breast cancer metastases in routine practice. The stained slides were independently evaluated by 8 pathologists. Read More

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UroVysion Multi-Target Fluorescence in situ Hybridization Assay for the Detection of Malignant Bile Duct Brushing Specimens: A Comparison with Routine Cytology.

Authors:
Jing Zhai

Acta Cytol 2018 May 7:1-7. Epub 2018 May 7.

Objective: Routine bile duct brushing cytology is an important diagnostic tool in the evaluation of bile duct stricture. The purpose of this study was to evaluate the performance of the UroVysion fluorescence in situ hybridization (FISH) assay for the detection of malignant bile duct brushing specimens.

Study Design: Thirty-five bile duct brushing specimens were included in the study. Read More

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Preoperative Diagnosis of Neoplastic or Malignant Hürthle Cell Lesions: A Chimera?

Acta Cytol 2018 3;62(3):193-203. Epub 2018 May 3.

Objective: We aimed to review all cytological specimens with Hürthle cells (HC) diagnosed in our institution, identify cytological features related to neoplastic (adenoma or carcinoma) and malignant histology, and discuss the role of clinicopathological findings and clinical management in these cases.

Study Design: We included 359 thyroid fine-needle aspiration cytology cases in our study. We reviewed the clinical and cytological features of surgical cases and correlated them with histological diagnosis. Read More

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Influence of the Histopathological Features of the Lesion on the Diagnostic Yield of Fine-Needle Aspiration Cytology of Pancreatic Solid Lesions.

Acta Cytol 2018 Apr 27:1-6. Epub 2018 Apr 27.

Department of Endoscopy (Endoscopic Ultrasonography Unit), Hospital Clínico Universitario San Carlos, Madrid, Spain.

Objective: The rate of pancreatic lesions has increased in recent decades due to the widespread use of advanced imaging techniques. Nowadays, a significant proportion of cases are incidentally discovered in asymptomatic patients and cytology is an important tool for the diagnosis and multidisciplinary management of these cases.

Study Design: In this study we retrospectively review the experience with pancreatic fine-needle aspiration cytology in the last 17 years at a single large tertiary hospital in Madrid, Spain. Read More

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Amyloidoma of Stomach: A Case Report.

Acta Cytol 2018 25;62(3):231-233. Epub 2018 Apr 25.

Department of Pathology, Hofstra Northwell School of Medicine, New Hyde Park, New York, USA.

Objective: Amyloidomas are tumor-like deposits of amyloid. Amyloidoma of the gastrointestinal tract is rare. To the best of our knowledge, this is the first instance of diagnosis of an amyloidoma in the gastrointestinal tract by fine needle aspiration (FNA). Read More

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Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence.

Acta Cytol 2018 25;62(3):166-177. Epub 2018 Apr 25.

Breast Division, Cancer Institute of São Paulo, University of São Paulo School of Medicine, São Paulo, Brazil.

Background: Although the association of human papillomavirus (HPV) with many cancers is well established, the involvement of HPV in breast cancer remains controversial. The purpose of this study is to perform a comprehensive review of the results and methods used to demonstrate that HPV markers are present in human breast cancer, and how well these studies fulfil the criteria for proving the viral etiology of a cancer.

Study Design: We conducted a search for molecular studies published until November 2016 that relate human breast cancer to HPV. Read More

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June 2018
1 Read

Role of FNA and Special Stains in Rapid Cytopathological Diagnosis of Pulmonary Nocardiosis.

Acta Cytol 2018 18;62(3):178-182. Epub 2018 Apr 18.

Department of Chest and Pulmonary Medicine, Dayanand Medical College and Hospital, Ludhiana, India.

Background: Nocardia, a gram-positive aerobic bacillus of the Actinomycetales family, is a significant opportunistic pathogen in immunocompromised individuals. Clinical and radiological features of pulmonary nocardiosis are nonspecific and can be misdiagnosed as tuberculosis, pneumocystis, staphylococcal or fungal infections, or as malignancy. Aspiration cytology with special stains is a quick and effective approach for accurate diagnosis. Read More

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June 2018
1 Read

Cytological Findings of Malignant and Benign Head and Neck Masses in Somalia.

Authors:
Yılmaz Baş

Acta Cytol 2018 11;62(3):183-192. Epub 2018 Apr 11.

Hitit University, Erol Olçok Education and Research Hospital, Department of Pathology, Çorum, Turkey.

Objective: There are no up-to-date records on head and neck masses (HNMs) in Somalia. This cytological study is the first to demonstrate the benefits and findings of fine-needle aspiration cytology in evaluating HNMs in the adult population of Somalia.

Study Design: A total of 116 aspiration samples were taken from different levels of the neck region, except for the thyroid. Read More

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June 2018
1 Read

Vessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas.

Acta Cytol 2018 5;62(3):223-230. Epub 2018 Apr 5.

Department of Pathology, Tokai University School of Medicine, Isehara, Japan.

Objective: The aim of this study was to determine whether intraoperative cytological evaluation of squash preparations is of benefit for differentiating high-grade from low-grade astrocytomas.

Methods: Squash preparations of 42 astrocytomas were classified histologically according to the World Health Organization (WHO) 2007 classification system as grade II (n = 12), grade III (n = 11), and grade IV (n = 19) and were divided into 2 groups, namely a low-grade group (grade II) and a high-grade group (grades III and IV). The focus was on morphological cell and vessel characteristics, namely nuclear atypia, chromatin pattern, nuclear enlargement, variation in nuclear size, the presence of nucleoli, mitosis, tumor necrosis, cell density, multibranched vessels, and vascular dilatation, and these characteristics were compared between the low- and high-grade groups. Read More

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June 2018
3 Reads

The Role of Crush Cytology in the Diagnosis of Large-Intestine Lesions with Correlation on Histopathology.

Acta Cytol 2018 4;62(3):215-222. Epub 2018 Apr 4.

Objective: To study the efficacy of colonoscopic crush cytology as a convenient and near-accurate method to evaluate colonic neoplasms.

Study Design: Retrospective and cross-sectional. The original cytologic diagnoses were correlated with a histology report on 100 cases sent to the cytology laboratory over 2 years. Read More

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June 2018
7 Reads

Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive Lymphoid Proliferation Using Thyroid Liquid-Based Cytology.

Acta Cytol 2018 29;62(2):93-98. Epub 2018 Mar 29.

Department of Surgery, Kuma Hospital, Kobe, Japan.

Objective: To identify cytological differences between mucosa-associated lymphoid tissue lymphoma (MALT-L) and nonneoplastic lymphocytes using thyroid liquid-based cytology (LBC).

Study Design: We observed LBC and conventional specimens from 35 MALT-L cases, 3 diffuse large B-cell cell lymphoma (DLBCL) cases, and 44 prominent nonneoplastic lymphocytic infiltration cases.

Results: In MALT-L cases, the incidence of lymphoglandular bodies in the LBC specimens was lower than that in the conventional specimens (p < 0. Read More

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April 2018
1 Read

Impact of Implementing 100% Rapid Review as a Quality Control Tool in Cervical Cytology.

Acta Cytol 2018 29;62(2):115-120. Epub 2018 Mar 29.

School of Pharmacy, Federal University of Goiás, Goiânia, Brazil.

Objective: We aimed to evaluate the impact of implementing 100% rapid review (100% RR) as a quality control tool in cervical smear cytology.

Design: A cross-sectional study was conducted in which cytology findings, false-negative results, and quality indicators were evaluated. The variables were analyzed in 2004, the year in which 100% RR was implemented, and again in 2013, i. Read More

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April 2018
1 Read

Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis.

Acta Cytol 2018 27;62(2):99-103. Epub 2018 Mar 27.

Department of E.N.T, Charles Nicolle Hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

Objective: This study assesses the role of fine-needle aspiration cytology (FNAC) in the diagnosis of tuberculous lymphadenitis (TL) in comparison with histology and bacteriology findings.

Study Design: We undertook a descriptive retrospective study of 937 FNAC specimens from 851 patients with cervical lymph nodes. The FNAC findings were then compared to histopathology and bacteriology. Read More

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April 2018
7 Reads
1.56 Impact Factor

Dual p16 and Ki-67 Expression in Liquid-Based Cervical Cytological Samples Compared to Pap Cytology Findings, Biopsies, and HPV Testing in Cervical Cancer Screening: A Diagnostic Accuracy Study.

Acta Cytol 2018 22;62(2):104-114. Epub 2018 Mar 22.

Pathology Department, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.

Objective: Our objective was to verify the sensitivity and specificity of dual immunocytochemistry staining for p16 and Ki-67 in liquid-based samples (the "dual" assay) for cervical lesion screening, compared to biopsy findings and human papillomavirus (HPV) DNA molecular detection.

Study Design: Sensitivity, specificity, and positive (PPV) and negative (NPV) predictive values for the "dual immunocytochemistry assay" were calculated and compared to histopathological results and to high-risk HPV DNA detection in adult women or teenagers submitted to cervical cancer screening.

Results: A total of 151 women were included. Read More

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April 2018
4 Reads

Assessment of the Utility of Cytology and Flow Cytometry of Cerebrospinal Fluid Samples in Clinical Practice.

Acta Cytol 2018 6;62(2):130-136. Epub 2018 Mar 6.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.

Objectives: We sought to assess the utility and limitations of both flow cytometry (FC) and cytology for the analysis of cerebrospinal fluid (CSF) in a practical clinical setting.

Methods: A total of 393 consecutive CSF samples from 171 patients submitted for both cytomorphologic and FC assessments were analyzed.

Results: Both FC and cytology findings were negative for malignancy in 315/393 samples (80%), and either positive (POS) or suspicious/atypical (SUSP/AT) in 7% of samples. Read More

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April 2018
1 Read

Atypia of Undetermined Significance in Thyroid Fine-Needle Aspirations: Follow-Up and Outcome Experience in Newfoundland, Canada.

Acta Cytol 2018 27;62(2):85-92. Epub 2018 Feb 27.

Introduction: The rates of atypia of undetermined significance (AUS) by fine-needle aspiration (FNA) and malignant outcomes have been estimated at < 7% and 5-15%, respectively. Initial AUS diagnosis is followed up clinically with serial ultrasounds, repeat FNA, molecular testing, or direct surgery. We investigated the incidence, follow-up modalities, and final outcomes of AUS in Newfoundland. Read More

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April 2018
1 Read

Oral Brush Liquid-Based Cytology: A Study of Concordance between a Cytotechnologist and a Cytopathologist.

Acta Cytol 2018 2;62(2):121-129. Epub 2018 Feb 2.

Department of Pathology, Uttar Pradesh University of Medical Sciences, Saifai, India.

Objective: Oral cancer accounts for almost 40% of all cancers in the Indian subcontinent. Techniques like oral scrape cytology are helpful in early diagnosis of premalignant lesion and thus prevention of malignant transformation. The purpose of this study is to evaluate the performance of cytotechnologists in assessing the adequacy and preliminary diagnostic accuracy of oral brush liquid-based cytology. Read More

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April 2018
8 Reads

Factors that Influence Sample Adequacy in Liquid-Based Cytology after Ultrasonography-Guided Fine-Needle Aspiration of Thyroid Nodules: A Single-Center Study.

Acta Cytol 2018 Jan 23. Epub 2018 Jan 23.

Department of Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Republic of Korea.

Objective: The factors that influence the acquisition of adequate samples during liquid-based cytology (LBC) remain unclear. This study aimed to identify factors that affect cytological adequacy in LBC after ultrasonography (US)-guided fine-needle aspiration (US-FNA) of thyroid nodules.

Study Design: From January 2017 to May 2017, a single radiologist performed US-FNA to diagnose 112 thyroid nodules in 112 consecutive patients. Read More

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January 2018
1 Read

Application of Immunocytochemistry on Cell Block Sections for the Investigation of Thyroid Lesions.

Acta Cytol 2018 16;62(2):137-144. Epub 2018 Jan 16.

Second Department of Pathology, University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.

Objective: To investigate the potential of Classification and Regression Trees (CARTs) for the diagnosis of thyroid lesions based on cell block immunocytochemistry and cytological outcome.

Study Design: A total of 956 histologically confirmed cases (673 benign and 283 malignant) from patients with thyroid nodules were prepared via liquid-based cytology and evaluated; 4 additional slides were stained for cytokeratin 19 (CK-19), galectin 3 (Gal-3), Hector Battifora mesothelial cell 1 (HBME-1), and thyroglobulin. On the basis of immunocytochemistry and the cytological diagnosis, a CART algorithm was constructed and used for evaluation. Read More

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April 2018
6 Reads

Cytologic Features of Malignant Melanoma with Osteoclast-Like Giant Cells.

Acta Cytol 2018 13;62(2):151-154. Epub 2018 Jan 13.

Department of Pathology, University Hospital La Princesa, Madrid, Spain.

Background: Malignant melanoma showing numerous osteoclast-like giant cells (OGCs) is an uncommon morphologic phenomenon, rarely mentioned in the cytologic literature. The few reported cases seem to have an aggressive clinical behavior. Although most findings support monocyte/macrophage differentiation, the exact nature of OGCs is not clear. Read More

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April 2018
4 Reads

V600E BRAF versus Non-V600E BRAF Mutated Lung Adenocarcinomas: Cytomorphology, Histology, Coexistence of Other Driver Mutations and Patient Characteristics.

Acta Cytol 2018 11;62(2):79-84. Epub 2018 Jan 11.

Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.

Objectives: We analyzed the morphologic features and clinical characteristics of lung adenocarcinomas (ACAs) harboring mutated BRAF.

Study Design: A review of the histology/cytology of BRAF-mutated lung ACAs was performed at the Johns Hopkins Hospital from January 1, 2013, to January 1, 2015. Patient demographics, clinical history, and ACA morphology were assessed. Read More

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April 2018
7 Reads

Cytology Formation: "A Neutrophilic Happy New Year".

Acta Cytol 2018 6;62(1):1-2. Epub 2018 Jan 6.

Department of Pathology and Laboratory Medicine, Sheikh Khalifa Medical City, Abu Dhabi, UAE.

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February 2018
5 Reads

Cytomorphological Findings of Follicular Dendritic Cell Sarcoma on Fine-Needle Aspiration Cytology.

Acta Cytol 2018 23;62(2):145-150. Epub 2017 Dec 23.

Department of Pathology, Chirayu Medical College and Hospital, Bhopal, India.

Background: Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm arising from follicular dendritic cells of germinal centers. The most common site of origin is lymph nodes and it may mimic a variety of tumors at that location, including carcinomas and sarcomas. Diagnosis is frequently missed on cytology as there are very few case reports describing the cytological characteristics of the lesion. Read More

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April 2018
8 Reads

Digital Applications in Cytopathology: Problems, Rationalizations, and Alternative Approaches.

Acta Cytol 2018 29;62(1):68-76. Epub 2017 Nov 29.

Department of Pathology, Cytopathology Section, Sidra Medicine, Qatar Foundation, Doha, Qatar.

Objective: The aim of this work was to raise awareness of problems using digital applications for examining, teaching, and applying telecytology at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia; University of Nebraska Medical Center (UNMC), Omaha, NE, USA; and University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA. The objective was to rationalize problems and propose alternative digital approaches.

Study Design: We sought to identify solutions to improve the following: (a) interpretive examination scores at KAMC for complex cytological templates (i. Read More

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March 2018
4 Reads

Analysis of the Cytomorphological Features in Atypical Urine Specimens following Application of The Paris System for Reporting Urinary Cytology.

Acta Cytol 2018 18;62(1):54-61. Epub 2017 Nov 18.

Northwell Health, Staten Island University Hospital, Department of Pathology, Staten Island, NY, USA.

Background: This study investigates the use of The Paris System (TPS) for Reporting Urinary Cytopathology and examines the performance of individual and combined morphological features in atypical urine cytologies.

Methods: We reviewed 118 atypical cytologies with subsequent bladder biopsies for the presence of several morphological features and reclassified them into Paris System categories. The sensitivity and specificity of individual and combined features were calculated along with the risk of malignancy. Read More

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March 2018
9 Reads

Modified Alcohol-Formalin Cell Block Technique in Head and Neck Pathology Diagnosis.

Acta Cytol 2018 15;62(1):39-43. Epub 2017 Nov 15.

Department of Oral Pathology and Microbiology, KLE University's KLE VK Institute of Dental Sciences and Hospital, Belagavi, India.

Objectives: Cell block preparation is a recognized technique in histopathological diagnosis. This technique aids in maintaining an intact architecture and reducing the diagnostic errors associated with fine-needle aspiration cytology. Numerous techniques have been put forth, but the need for an optimal technique for routine use in the laboratory still persists. Read More

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March 2018
6 Reads

Comparison of Visual Inspection with Acetic Acid and the Pap Smear for Cervical Cancer Screening.

Acta Cytol 2018 15;62(1):34-38. Epub 2017 Nov 15.

Department of Obstetrics and Gynaecology, Era's Lucknow Medical College, Lucknow, India.

Objective: To evaluate the efficacy of visual inspection with acetic acid (VIA) in the early detection of cervical cancer and compare it with the Pap smear.

Study Design: This was a cross-sectional study conducted over a period of 3 months. A total of 316 patients who attended the Gynecology Outpatient Department of Era's Lucknow Medical College and Hospital, fulfilled the inclusion criteria, and gave their informed consent were included. Read More

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March 2018
5 Reads

Atypical Squamous Cells in Liquid-Based Cervical Cytology: Microbiology, Inflammatory Infiltrate, and Human Papillomavirus-DNA Testing.

Acta Cytol 2018 8;62(1):28-33. Epub 2017 Nov 8.

Department of Pathology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.

Objective: The aim of this study was to assess the correlation between atypical squamous cells (ASC) and inflammatory infiltrate and vaginal microbiota using cervical liquid-based cytological (SurePath®) and high-risk human papillomavirus (HR-HPV) tests.

Study Design: A cross-sectional study was conducted using a 6-year database from a laboratory in Fortaleza (Brazil). Files from 1,346 ASC cases were divided into subgroups and results concerning inflammation and vaginal microorganisms diagnosed by cytology were compared with HR-HPV test results. Read More

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March 2018
5 Reads

Characteristics of False-Negative Thyroid Fine-Needle Aspirates.

Acta Cytol 2018 4;62(1):12-18. Epub 2017 Nov 4.

Department of Pathology, Baptist Hospital of Miami and Miami Cancer Institute, Miami, FL, USA.

Introduction: False-negative thyroid fine-needle aspirates (FNA) are not well characterized.

Methods: We correlated the results of all thyroid aspirations from 1997 to 2016 with histologic follow-up.

Results: There were 13,733 aspirates, 2,112 (15. Read More

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March 2018
4 Reads

High-Grade Urothelial Carcinoma on Urine Cytology Resembling Umbrella Cells.

Acta Cytol 2018 11;62(1):62-67. Epub 2017 Nov 11.

Department of Pathology, Baptist Hospital of Miami and Miami Cancer Institute, Miami, FL, USA.

Context: High-grade urothelial carcinoma (UC) cells have many appearances on urine cytology, but according to The Paris System, they can be easily distinguished from umbrella cells.

Objective: We aimed to define the incidence and appearance of high-grade UC cells that resemble umbrella cells in Cytospin preparations on urine cytology.

Results: Cytospin preparations from 331 cases with biopsy follow-up (230 benign/low-grade and 101 malignant [22 carcinoma in situ, 52 papillary, 19 invasive UC, 8 other] cases) were reviewed. Read More

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March 2018
5 Reads