7,890 results match your criteria Acta cytologica[Journal]


Current Status of p16 Immunohistochemistry and HPV Testing in Fine Needle Aspiration Specimens of the Head and Neck.

Acta Cytol 2019 Feb 15:1-10. Epub 2019 Feb 15.

Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania,

Human papilloma virus (HPV)-related squamous cell carcinoma (SCC) is biologically unique and has a better prognosis than conventional SCC of the head and neck. p16 immunohistochemistry emerged as a valuable surrogate marker for HPV in oropharyngeal SCC. The criteria for a positive p16 result in tissue specimens are well established. Read More

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http://dx.doi.org/10.1159/000496158DOI Listing
February 2019

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity.

Acta Cytol 2019 Feb 15:1-11. Epub 2019 Feb 15.

Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.

Persistent high-risk human papillomavirus (HPV) infection has been associated with increased risk for cervical precancerous lesions and cancer. The host's genetic variability is known to play a role in the development of cervical cancer. The human leukocyte antigen (HLA) genes are highly polymorphic and have shown to be important risk determinants of HPV infection persistence and disease progression. Read More

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https://www.karger.com/Article/FullText/494985
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http://dx.doi.org/10.1159/000494985DOI Listing
February 2019
2 Reads

Breast Fine Needle Aspiration Biopsy Cytology Using the Newly Proposed IAC Yokohama System for Reporting Breast Cytopathology: The Experience of a Single Institution.

Acta Cytol 2019 Feb 15:1-6. Epub 2019 Feb 15.

Institute of Molecular Pathology and Immunology, University of Porto, Porto,

Objective: Recently the International Academy of Cytology (IAC) proposed a new reporting system for breast fine needle aspiration biopsy (FNAB) cytology. We aimed to categorize our samples according to this classification and to assess the risk of malignancy (ROM) for each category as well as the diagnostic yield of breast FNAB.

Study Design: Breast FNAB specimens obtained between January 2007 and December 2017 were reclassified according to the newly proposed IAC Yokohama reporting system. Read More

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http://dx.doi.org/10.1159/000492638DOI Listing
February 2019

Liquid Biopsy beyond Circulating Tumor Cells and Cell-Free DNA.

Acta Cytol 2019 Feb 15:1-10. Epub 2019 Feb 15.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal (i3S), Porto,

Liquid biopsy represents the analysis of tumor-derived material in the blood and other body fluids of cancer patients. This portrays a minimally invasive detection tool for molecular biomarkers. Liquid biopsy has emerged as a complementary or alternative method to surgical biopsy. Read More

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http://dx.doi.org/10.1159/000493969DOI Listing
February 2019

Masood's and Modified Masood's Scoring Index: An Evaluation of Fine Needle Aspiration Cytology of Breast Lesions with Histopathological Correlation.

Acta Cytol 2019 Feb 13:1-7. Epub 2019 Feb 13.

Department of Pathology, ESIC Medical College, Faridabad, India.

Objective: As fine needle aspiration cytology (FNAC) is the primary tool for evaluation of breast lesions, it is essential to segregate lesions with low and high risk of malignancy. To address this, Masood proposed a cytological scoring system for categorization, Masood's Scoring Index (MSI), which was modified later (Modified Masood's Scoring Index [MMSI]). This study analyses the effectiveness of MMSI over MSI and assesses the concordance between cytological scoring and histopathology. Read More

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http://dx.doi.org/10.1159/000496139DOI Listing
February 2019

Circulating Tumour Cells in Predictive Molecular Pathology: Focus on Drug-Sensitive Assays and 3D Culture.

Acta Cytol 2019 Feb 13:1-11. Epub 2019 Feb 13.

Department of Public Health, University of Naples Federico II, Naples,

Molecular cytopathology is a rapidly evolving field of cytopathology that provides biological information about the response to personalised therapy and about the prognosis of neoplasms diagnosed on cytological samples. Biomarkers such as circulating tumour cells and circulating tumour DNA are increasingly being evaluated in blood and in other body fluids. Such liquid biopsies are non-invasive, repeatable, and feasible also in patients with severe comorbidities. Read More

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http://dx.doi.org/10.1159/000496213DOI Listing
February 2019

A Study of Pap Smears in HIV-Positive and HIV-Negative Women from a Tertiary Care Center in South India.

Acta Cytol 2019 Feb 5:1-6. Epub 2019 Feb 5.

Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, India.

Objectives: The aim of this work was to study the spectrum of epithelial abnormalities on Pap smears of HIV-positive women categorized as per the Bethesda System of Reporting Cervical Cytology, to correlate them with CD4 lymphocyte counts, and to compare them with the spectrum of abnormalities seen in a HIV-negative control group. Study Design and Methodology: The present study was a 6-year retrospective study conducted in the Department of Pathology at Kasturba Medical College, Mangalore, which included 150 Pap smears from HIV-positive and HIV-negative women, respectively. The Pap-stained slides of the cases were retrieved and studied. Read More

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http://dx.doi.org/10.1159/000496211DOI Listing
February 2019
4 Reads

Beta Human Papillomavirus and Associated Diseases.

Acta Cytol 2019 Jan 23:1-9. Epub 2019 Jan 23.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

The cutaneous human papillomavirus (HPV), mostly from β- and γ-HPV genus, is ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of β-HPVs and cutaneous squamous cell carcinoma (cSCC) development was initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis. Likewise, immunosuppressed organ transplant recipients have an increased susceptibility to β-HPV infections in the skin as well as to cSCC development. Read More

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https://www.karger.com/Article/FullText/492659
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http://dx.doi.org/10.1159/000492659DOI Listing
January 2019
3 Reads

Comparison of Conventional Cytology, Liquid-Based Cytology, and Cell Block in the Evaluation of Peritoneal Fluid in Gynecology Malignancies.

Acta Cytol 2019 Jan 9:1-10. Epub 2019 Jan 9.

Pathology Department, Shiraz University of Medical Sciences, Shiraz,

Background: Peritoneal washing cytology has become an accepted method in evaluating gynecology malignancies.

Objective: The aim of this work was to compare the conventional cytology, liquid-based cytology (LBC), and cell block in the evaluation of peritoneal fluid.

Materials And Methods: A total of 48 cases with ovarian and uterine malignancy were included in this study. Read More

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http://dx.doi.org/10.1159/000495571DOI Listing
January 2019
4 Reads

Manufactured Cell Blocks: Turning Smears into Sections.

Acta Cytol 2019 Jan 4:1-7. Epub 2019 Jan 4.

PathWest Laboratory Medicine, QE2 Medical Centre, Nedlands, Washington,

Whilst cytological smears are still the basis of cytodiagnosis, there is an increasing role for ancillary testing. Specimens obtained are not always optimal, often with limited material for ancillary studies. Several reports have described the utility of scraping material from cytological smears to manufacture cell blocks to provide material for ancillary studies. Read More

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http://dx.doi.org/10.1159/000493907DOI Listing
January 2019
6 Reads

Liquid Biopsy and Lung Cancer.

Acta Cytol 2018 Dec 19:1-8. Epub 2018 Dec 19.

The identification of non-small cell lung cancer (NSCLC) patients potentially responsive to targeted therapies relies on a number of relevant biomarkers, including EGFR, ALK, ROS-1, and PD-L1. Biomarker identification is most commonly based on surgical sample collection. However, when tissues are difficult to reach or when multiple analyses are necessary to monitor tumor progression and treatment response, liquid biopsy is a valid noninvasive alternative. Read More

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https://www.karger.com/Article/FullText/492710
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http://dx.doi.org/10.1159/000492710DOI Listing
December 2018
10 Reads

Study of the Pre-Analytical Phase of an ISO 15189: 2012-Certified Cytopathology Laboratory: A 5-Year Institutional Experience.

Acta Cytol 2018 Dec 19:1-7. Epub 2018 Dec 19.

Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, India.

Objective: Total quality management, which basically involves pre-analytical, analytical, and postanalytical phases, is relatively more difficult in cytopathology due to descriptive reports and subjective variability. The pre-analytical phase of total quality management constitutes a major burden of errors in the laboratory and it has not been widely studied in cytopathology except in cervical Pap smears. The present study was therefore conducted to study the pre-analytical phase over 5 years from April 2013 until May 2018 at an ISO 15189: 2012-certified cytopathology laboratory, in a resource-limited setting. Read More

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https://www.karger.com/Article/FullText/494567
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http://dx.doi.org/10.1159/000494567DOI Listing
December 2018
13 Reads

Adaptation of Alpha-Papillomavirus over Millennia.

Acta Cytol 2018 Dec 13:1-3. Epub 2018 Dec 13.

Papillomaviruses (PVs) are a group of small DNA viruses that, with around 350 million years of evolution, acquired the capacity of infecting a broad range of vertebrates, including humans. To date, more than 300 PV types have been isolated. Viruses that have a long common evolutionary history with their host typically cause unapparent infections. Read More

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https://www.karger.com/Article/FullText/492658
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http://dx.doi.org/10.1159/000492658DOI Listing
December 2018
10 Reads

Subcutaneous Fat Necrosis of the Newborn: Is Fine Needle Aspiration Cytology Diagnostic?

Acta Cytol 2018 Dec 13:1-3. Epub 2018 Dec 13.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.

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http://dx.doi.org/10.1159/000494501DOI Listing
December 2018
4 Reads

Correlation of Ultrasound Findings and Fine-Needle Aspiration Cytology for the Diagnosis of Axillary Lymph Node Metastasis in Patients with Breast Carcinoma.

Acta Cytol 2018 Dec 5:1-6. Epub 2018 Dec 5.

Department of Cytology, Kuwait Cancer Control Center, Safat, Kuwait.

Objective: Ultrasound-guided fine-needle aspiration cytology (USG-FNAC) is used for the detection of axillary lymph node (ALN) metastasis in patients with breast carcinoma (BC). US findings have a good diagnostic accuracy with high sensitivity and specificity. The aim of this study is to correlate the detection of ALN metastases on US with FNAC in BC patients. Read More

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https://www.karger.com/Article/FullText/493635
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http://dx.doi.org/10.1159/000493635DOI Listing
December 2018
6 Reads

Three-Tiered versus Two-Tiered Classification of Squamous Dysplasia in Cervical Cytology: Results of a Follow-Up Study.

Acta Cytol 2018 Dec 5:1-6. Epub 2018 Dec 5.

Institut für Biometrie und Klinische Epidemiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objective: Regarding cytological findings of squamous dysplasia, a comparison was made between a three-tiered classification - low-grade squamous intraepithelial lesion (LSIL), high-grade SIL/cervical intraepithelial neoplasia 2 (HSIL/CIN2), and HSIL/CIN3 - and a two-tiered classification - LSIL and HSIL. The respective risk for CIN2+ and CIN3+ was calculated to make decisions regarding management.

Methods: A total of 2,949 women with first-time cytologic findings of squamous dysplasia (LSIL, HSIL/CIN2, or HSIL/CIN3) between January 2013 and June 2016 were enrolled. Read More

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http://dx.doi.org/10.1159/000494984DOI Listing
December 2018
3 Reads

Retinal Anlage Tumor of Epididymis: A Diagnostic Challenge on Cytology.

Acta Cytol 2018 Nov 19:1-2. Epub 2018 Nov 19.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.

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http://dx.doi.org/10.1159/000494124DOI Listing
November 2018
1 Read

BRAF V600 Mutational Status in Melanoma Correlates with Cytologic Features in Fine-Needle Aspirate Specimens.

Acta Cytol 2018 Nov 5:1-7. Epub 2018 Nov 5.

Melanomas are known as the great mimicker and must be considered in the differential diagnosis of any fine-needle aspirations (FNA). Despite recent advancements in understanding of the mutational landscape of melanomas, there still exists a divide between the genetic and morphologic correlates. A consecutive cohort of 39 FNA of clinically verified metastatic melanomas with concurrent BRAF V600 assessment were selected [positive (n = 18) and wild-type (n = 21)]. Read More

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http://dx.doi.org/10.1159/000491814DOI Listing
November 2018
12 Reads

Diagnostic Accuracy of Fine-Needle Aspiration Cytology for Discrimination of Squamous Cell Carcinoma from Adenocarcinoma in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.

Acta Cytol 2018 31;62(5-6):318-326. Epub 2018 Oct 31.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, USA.

Objective: To determine the accuracy with which morphology alone can distinguish adenocarcinoma and squamous cell carcinoma in non-small cell lung cancer.

Methods: We performed a systematic review and meta-analysis. Three data bases (MEDLINE, EMBASE, Scopus) were searched for studies on the diagnostic accuracy of subtyping non-small cell lung cancer. Read More

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https://www.karger.com/Article/FullText/493942
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http://dx.doi.org/10.1159/000493942DOI Listing
January 2019
5 Reads

Cytomorphologic, Imaging, Molecular Findings, and Outcome in Thyroid Follicular Lesion of Undetermined Significance/Atypical Cell of Undetermined Significance (AUS/FLUS): A Mini-Review.

Acta Cytol 2018 Oct 31:1-9. Epub 2018 Oct 31.

Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Objectives: Since the introduction of the entity of "Atypical cell of undetermined significance /follicular lesion of undetermined significance" (AUS/FLUS) by The Bethesda System for Reporting Thyroid Cytology (TBSRTC) in 2007, there have been many published studies about the cytomorphologic criteria, subclassification, outcome, and management of patients with the diagnosis of AUS/FLUS. There have been many studies in different aspects of this indeterminate category, i.e. Read More

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https://www.karger.com/Article/FullText/493908
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http://dx.doi.org/10.1159/000493908DOI Listing
October 2018
11 Reads

The Differential Diagnosis in Nonlymphoproliferative Malignant Pleural Effusion Cytopathology and Its Correlation with Patients' Demographics.

Acta Cytol 2018 31;62(5-6):436-442. Epub 2018 Oct 31.

Division of Cytopathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Background: We report our experience with malignant pleural effusion (MPE) and the impact of patients' demographics on the differential diagnosis at the primary site.

Methods: After IRB approval, we searched our pathology database from January 2013 to January 2017 for patients with positive pleural effusions (PEs). Patients' demographics and clinical histories were noted. Read More

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http://dx.doi.org/10.1159/000493336DOI Listing
January 2019
6 Reads

Reliability of Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Expression on Breast Cancer Cells Stored in Cellprep® Vials.

Acta Cytol 2018 31;62(5-6):360-370. Epub 2018 Oct 31.

Department of Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan.

Objective: The aim of this study was to evaluate the reliability of estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) expression levels in Cellprep® (CP).

Study Design: We evaluated the stability of immunocytochemistry (ICC) of ER and HER2 for primary or recurrent breast cancer samples rinsed in CP vials. Samples were prepared from CP vials stored for 1-30 or 160-240 days. Read More

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http://dx.doi.org/10.1159/000492501DOI Listing
January 2019
2 Reads

Cytological Findings in Benign Phyllodes Tumors.

Acta Cytol 2018 Oct 26:1-5. Epub 2018 Oct 26.

Objective: Phyllodes tumors are fibroepithelial breast lesions with many cytological and histopathological similarities to fibroadenomas. The aim of this study was to investigate cytological findings in benign phyllodes tumors.

Study Design: Seventy-six histologically proven cases of benign phyllodes tumors were selected from 1982 to 2017. Read More

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http://dx.doi.org/10.1159/000493677DOI Listing
October 2018
3 Reads

Eco-Pap: The Ecological Modification of the Papanicolaou Stain for Sustainable Cervical Cancer Diagnosis.

Acta Cytol 2018 Oct 23:1-9. Epub 2018 Oct 23.

Department of Pathology, Hospital Nacional Docente Madre-Niño San Bartolomé, Lima, Peru.

Objectives: To validate the ecological modification of the Papanicolaou stain (Eco-Pap) for the diagnosis of cervical cancer.

Study Design: A prospective study was performed at the Mother and Child "San Bartolomé" Hospital, Lima, Peru. Reagent handling strategies were divided into three phases: we used (1) Harris progressive hematoxylin (for nuclear staining), (2) a polychromatic solution (a mix of EA-36/Orange G-6 to suppress the use of several alcohol baths), and (3) direct mounting (with Entellan® solution). Read More

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http://dx.doi.org/10.1159/000493113DOI Listing
October 2018
1 Read

Cytologic Features of SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Comparison with Other SWI/SNF Complex-Deficient Tumors.

Acta Cytol 2018 4;62(5-6):456-462. Epub 2018 Oct 4.

Division of Molecular Pathology, Faculty of Medicine, Tottori University, Yonago,

Background: SMARCA4-deficient thoracic sarcoma is a recently proposed entity of soft tissue tumors associated with an extremely poor prognosis. Its cytologic features have not been well described in the literature yet.

Case: A woman in her early 30s who presented with chest pain was found to have a tumor in the right chest wall. Read More

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http://dx.doi.org/10.1159/000493335DOI Listing
January 2019
1 Read

Cytopathology of Solid Variant of Papillary Thyroid Carcinoma: Differential Diagnoses with other Thyroid Tumors.

Acta Cytol 2018 25;62(5-6):371-379. Epub 2018 Sep 25.

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Objectives: Solid variant of papillary thyroid carcinoma (SVPTC) is rare, differing from classical PTC (cPTC) in architecture and outcome. We evaluated the cytomorphology of SVPTC cases to assess the feasibility of a preoperative diagnosis.

Study Design: SVPTC cases were evaluated for architecture, nuclear features, and Bethesda category and were compared with noninvasive follicular thyroid neoplasm with papillary-like nuclear features/follicular variant of PTC (NIFTP/FVPTC), cPTC, and poorly differentiated thyroid carcinoma (PDTC). Read More

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http://dx.doi.org/10.1159/000493081DOI Listing
January 2019
2 Reads

Cytological Findings of Gastrointestinal Stromal Tumor-Derived Bone Metastasis.

Acta Cytol 2018 25;62(5-6):430-435. Epub 2018 Sep 25.

Department of Pathology, the Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.

Objective: Procedures for diagnosing bone tumors should be rapid and minimally invasive. Thus, cytological examinations are more useful for such purposes than histological examinations. In order to identify cytomorphological findings that could be used to diagnose bone metastasis from gastrointestinal stromal tumors (GIST), previous cases were reviewed. Read More

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https://www.karger.com/Article/FullText/492709
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http://dx.doi.org/10.1159/000492709DOI Listing
January 2019
22 Reads

Stromal Cellular Fragments in Breast Fine Needle Aspirates: Think Outside of the Box.

Acta Cytol 2018 24;62(5-6):450-455. Epub 2018 Sep 24.

Pathology Department, Faculdade de Medicina da Universidade do Porto, Porto,

Background: The presence of highly cellular stromal fragments in breast fine needle aspirates (FNA) suggests some classical differential diagnoses such as cellular fibroadenoma, phyllodes tumour (PT), metaplastic carcinomas, and some mesenchymal/myoepithelial proliferations. The other components of the smears can help in the differential diagnosis, but the presence of a low-grade epithelial proliferation does not always represent a fibro-epithelial lesion as we demonstrate in these two cases.

Cases: We discuss two cases of breast FNA, previously presented in a slide seminar at the 29th European Congress of Pathology in Amsterdam, where the common cytological finding was the presence of stromal cellular fragments together with an epithelial component. Read More

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https://www.karger.com/Article/FullText/492566
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http://dx.doi.org/10.1159/000492566DOI Listing
January 2019
12 Reads

Glandular Cell Abnormalities on SurePath Preparations: A Retrospective Review with Cytology-Histology Correlations.

Acta Cytol 2018 21;62(5-6):423-429. Epub 2018 Sep 21.

Objective: Detecting glandular lesions is challenging by all Pap test methodologies. As the availability of data on identifying glandular abnormalities by SurePath is scarce, we investigated the detection rates and the correlation with histology follow-up.

Study Design: A total of 105,927 cases (SurePath and conventional) were searched for the diagnosis of atypical glandular cells or higher glandular abnormalities (AGC+) with the corresponding histologic diagnosis. Read More

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http://dx.doi.org/10.1159/000493000DOI Listing
January 2019
1 Read

Utility of Rapid On-Site Cytologic Evaluation during Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Malignant and Nonmalignant Disease.

Acta Cytol 2018 21;62(5-6):380-385. Epub 2018 Sep 21.

Department of Pulmonology, Geneva University Hospitals, Geneva, Switzerland.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an accurate procedure to sample mediastinal tissue. Rapid on-site cytologic evaluation (ROSE) has been advocated to improve the performance of this procedure, but its benefit remains controversial. Our objective is to assess the utility of ROSE for EBUS-TBNA diagnostic accuracy among unselected patients. Read More

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http://dx.doi.org/10.1159/000493334DOI Listing
January 2019
2 Reads

Application of the Milan System for Risk Stratification and Its Comparison with a Previous Reporting System of Parotid Gland Cytopathology in a Tertiary Care Centre.

Acta Cytol 2018 17;62(5-6):352-359. Epub 2018 Sep 17.

Objective: To compare the recently proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) with the four-tiered reporting system (FTRS) followed at our institute.

Methods: Parotid gland fine-needle aspirates reported over a period of 5 years were analysed. These aspirates had been placed into 4 categories according to the FTRS: unsatisfactory (UNS), no evidence of malignancy/negative (NEG), inconclusive for malignancy (INC), and diagnostic for malignancy/positive (POS). Read More

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http://dx.doi.org/10.1159/000492051DOI Listing
January 2019
1 Read

Potential Difficulties in Cytological Approach of Basal Cell Adenoma of Salivary Glands: The Experience of a Single Institution.

Acta Cytol 2018 25;62(5-6):346-351. Epub 2018 Jul 25.

Objective: Basal cell adenoma (BCA) is an uncommon benign epithelial neoplasm of salivary glands, which was first described by Kleinsasser and Klein in 1967 and which derives its name from the monomorphic basaloid appearance of tumor cells. This tumor represents 1-2% of all salivary gland epithelial tumors; the most common site of occurrence is the parotid gland. It usually arises in adults over 50 years of age with slight female prevalence. Read More

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http://dx.doi.org/10.1159/000490692DOI Listing
January 2019
13 Reads

Postmenopausal Squamous Atypia: Cytologic Features, Hybrid Capture 2 Tests and Contribution to the ASCUS Pool.

Acta Cytol 2018 25;62(5-6):418-422. Epub 2018 Jul 25.

Department of Pathology, Ohio State University Wexner Medical Center, Columbus, Ohio,

Objective: Postmenopausal squamous atypia (PSA) mimics squamous intraepithelial lesion (SIL). We investigate the PSA contribution to the atypical squamous cells of undetermined significance (ASCUS) pool, its cytologic features and Hybrid Capture 2 (HC2) relative light unit/cutoff (RLU/CO) values.

Study Design: 658 ASCUS Pap tests in women ≥55 years were reviewed to select those with koilocyte-like cells and/or atypical parakeratosis. Read More

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https://www.karger.com/Article/FullText/490691
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http://dx.doi.org/10.1159/000490691DOI Listing
January 2019
13 Reads

High-Risk Types of Human Papilloma Virus DNA Testing in Women with False Negative Cytology.

Acta Cytol 2018 13;62(5-6):411-417. Epub 2018 Jul 13.

Department of Clinical Science, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.

Objective: To determine whether high-risk types of human papilloma virus (hrHPV) DNA testing is reliable for selection patients in need of further investigation with colposcopy in women with increased risk of high-grade cervical lesions as a result of false negative cytology. The secondary objective was to compare the sensitivity of hrHPV testing on self-collected versus physician-collected samples for the detection of histological high-grade cervical intraepithelial neoplasia (CIN2+).

Methods: Sixty-three patients identified with a missed abnormality following the re-evaluation of benign cervical cytology were included. Read More

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http://dx.doi.org/10.1159/000490487DOI Listing
January 2019
19 Reads

Curious Residents of the Thyroid Gland: Two Case Reports of Colorectal Carcinoma Metastasis by Fine-Needle Aspiration Diagnosis.

Acta Cytol 2018 13;62(5-6):443-449. Epub 2018 Jul 13.

Department of Pathology, University Hospitals of Leuven, Leuven, Belgium.

Background: The most frequent metastases to the thyroid originate in the kidney, lung or breast. Colorectal adenocarcinoma represents less than 4% of metastases to the thyroid gland. Solitary metastases of colorectal cancer with no other manifestation of disseminated cancer disease are exceedingly rare. Read More

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http://dx.doi.org/10.1159/000490367DOI Listing
January 2019
6 Reads

Significance of High-Risk Human Papillomavirus Testing for Atypical Glandular Cells on Cervical Cytology.

Acta Cytol 2018 10;62(5-6):405-410. Epub 2018 Jul 10.

Objectives: The aim of this study was to evaluate the diagnostic significance of high-risk human papillomavirus (hrHPV) testing for managing women with atypical glandular cells (AGC) and to explore the distribution of hrHPV genotypes.

Methods: We analyzed cytologic and histopathologic diagnoses in patients referred to our institution due to AGC or atypical squamous cells of undetermined significance (ASC-US). All patients underwent hrHPV testing and genotyping, and positive (PPV) and negative predictive values (NPV) for cervical intraepithelial neoplasia (CIN) 2 or worse [CIN2+/adenocarcinoma in situ (AIS)+] were calculated. Read More

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http://dx.doi.org/10.1159/000490230DOI Listing
January 2019
3 Reads

Atypical Glandular Cells: Interobserver Variability according to Clinical Management.

Acta Cytol 2018 3;62(5-6):397-404. Epub 2018 Jul 3.

Department of Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island,

Objective: The 2014 Bethesda System diagnostic criteria for atypical glandular cells (AGC) aids in classification of atypical cells in cervical cytology. There is limited literature regarding reproducibility and interobserver variability in the application of the 2014 AGC criteria. Our aim is to assess the interobserver variability of AGC with a focus on how diagnostic categories link with guideline-driven management. Read More

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http://dx.doi.org/10.1159/000489968DOI Listing
January 2019
21 Reads

Degenerated Keratinized Tumor Cells in Oropharyngeal Human Papilloma Virus-Associated Squamous Cell Carcinoma: A Pitfall in p16 Immunostaining of Fine-Needle Aspiration Specimens.

Acta Cytol 2018 2;62(5-6):339-345. Epub 2018 Jul 2.

Objective: High-risk human papilloma virus (HPV) testing should be performed on all patients with newly diagnosed oropharyngeal HPV-associated squamous cell carcinoma (OPHPVSCC), and p16 immunostaining can be used as a surrogate marker. Although in surgical pathology specimens p16 staining in > 70% of the tumor cells is considered a positive result, the interpretation in fine-needle aspiration (FNA) specimens has remained controversial.

Study Design: FNA of neck lymph nodes and corresponding surgical specimens from 42 patients with OPHPVSCC were reviewed. Read More

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http://dx.doi.org/10.1159/000490229DOI Listing
January 2019
8 Reads

Role of Field Staining in the Cytological Assessment of Intraoperative Surgical Specimens.

Acta Cytol 2018 25;62(5-6):327-332. Epub 2018 Jun 25.

Objective: To study the role of Field staining in scrape smears for intraoperative cytological (IOC) diagnosis. Specimens were assessed for categorizing among benign and malignant lesions, lymph node status, and adequacy of surgical cut margins as per specimen. Technique, adequacy, and quality were assessed along with comparison of cytological diagnosis with final histopathological diagnosis obtained on routine hematoxylin and eosin-stained slides. Read More

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http://dx.doi.org/10.1159/000489768DOI Listing
January 2019
5 Reads

Insulinoma-Associated Protein 1 Immunostain: A Diagnostic Tool for Pulmonary Small Cell Carcinoma in Cytology.

Acta Cytol 2018 22;62(5-6):333-338. Epub 2018 Jun 22.

Department of Pathology, Division of Cytopathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Objective: Cytology plays an important role in the diagnosis of small cell carcinoma (SCLC). Application of immunohistochemical (IHC) markers improves the accuracy and reproducibility of the diagnosis of SCLC. We report the application of insulinoma-associated protein 1 (INSM1) in the diagnosis of SCLC in cytology samples. Read More

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http://dx.doi.org/10.1159/000490091DOI Listing
January 2019
25 Reads

Validation of a New Low-Cost, Methanol-Based Fixative for Cervical Cytology and Human Papillomavirus Detection.

Acta Cytol 2018 18;62(5-6):393-396. Epub 2018 Jun 18.

Laboratorio Genoa/LPCM, São Paulo, Brazil.

Objective: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV).

Methods: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives. Read More

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http://dx.doi.org/10.1159/000489873DOI Listing
January 2019
4 Reads

Cell Block in Cytological Diagnostics: Review of Preparatory Techniques.

Acta Cytol 2018 15;62(4):237-243. Epub 2018 Jun 15.

Department of Pathology, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

Objective: The cell block (CB) technique refers to the processing of sediments, blood clots, or grossly visible tissue fragments from cytological specimens into paraffin blocks that can be cut and stained by the same methods used for histopathology. The technique brings additional tissue architectural information. CB can be used for ancillary techniques such as immunocytochemistry and molecular techniques. Read More

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http://dx.doi.org/10.1159/000489769DOI Listing
August 2018
32 Reads

Atypical Squamous Cells: Cytopathological Findings and Correlation with HPV Genotype and Histopathology.

Acta Cytol 2018 13;62(5-6):386-392. Epub 2018 Jun 13.

Department of Pathology, Federal University of Ceará, Fortaleza, Brazil.

Objective: We aimed to assess potential associations between atypical squamous cell (ASC) subgroups: ASC-US (undetermined significance) and ASC-H (cannot exclude high-grade squamous intraepithelial lesion), regarding cytomorphological features, high-risk (HR) human papillomavirus (HPV) testing, and histological outcomes in a sample of Brazilian women.

Study Design: Cross-sectional study which evaluated 1,346 liquid-based cytologies between January 2010 and July 2016 with ASC results. ASC-US and ASC-H were analyzed for frequency, diagnostic criteria, and cytological findings and compared with HR-HPV tests and histological outcomes. Read More

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http://dx.doi.org/10.1159/000489386DOI Listing
January 2019
3 Reads

Results of Cervical Cancer Screening in the Rural Population of Lucknow West, India, through a Camp Approach.

Acta Cytol 2018 13;62(4):273-278. Epub 2018 Jun 13.

Objective: Cytological screening was carried out in rural women of Lucknow West, India, through a camp approach to detect cervical cancer in its preinvasive phase and to see whether the primitive living conditions in the villages have any effect on the incidence of precancer and carcinoma of the cervix and the associated predisposing factors of cervical carcinogenesis.

Study Design: During a span of 4 years (May 2013 to March 2017), a total of 135 camps were organized under the auspice of Era's Lucknow Medical College and Hospital (Lucknow, India). Only 4,269 (31. Read More

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https://www.karger.com/Article/FullText/489078
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http://dx.doi.org/10.1159/000489078DOI Listing
August 2018
10 Reads

The Diagnostic Accuracy of Cytology for the Diagnosis of Hepatobiliary and Pancreatic Cancers.

Acta Cytol 2018 13;62(4):311-316. Epub 2018 Jun 13.

Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Objective: Although cytology testing is considered a valuable method to diagnose tumors that are difficult to access such as hepato-biliary-pancreatic (HBP) malignancies, its diagnostic accuracy remains unclear. We therefore aimed to investigate the diagnostic accuracy of cytology testing for HBP tumors.

Study Design: We performed a retrospective study of all cytology samples that were used to confirm radiologically detected HBP tumors between 2002 and 2016. Read More

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http://dx.doi.org/10.1159/000489549DOI Listing
August 2018
9 Reads

Evaluation of Sienna Cancer Diagnostics hTERT Antibody on 500 Consecutive Urinary Tract Specimens.

Acta Cytol 2018 6;62(4):302-310. Epub 2018 Jun 6.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Objectives: Telomerase activity can be detected in up to 90% of urothelial carcinomas (UC). Telomerase activity can also be detected in urinary tract cytology (UTC) specimens and indicate an increased risk of UC. We evaluated the performance of a commercially available antibody that putatively binds the telomerase reverse transcriptase (hTERT) subunit on 500 UTC specimens. Read More

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http://dx.doi.org/10.1159/000489181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317283PMC
August 2018
4 Reads

Rapid On-Site Evaluation of Fine-Needle Aspiration by Non-Cytopathologists: A Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies for Adequacy Assessment.

Acta Cytol 2018 6;62(4):244-252. Epub 2018 Jun 6.

Department of Pathology and ARUP Laboratories, University of Utah, Salt Lake City, Utah, USA.

Objective: Rapid on-site evaluation (ROSE) has been shown to improve adequacy rates and reduce needle passes. ROSE is often performed by cytopathologists who have limited availability and may be costlier than alternatives. Several recent studies examined the use of alternative evaluators (AEs) for ROSE. Read More

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http://dx.doi.org/10.1159/000489550DOI Listing
August 2018
13 Reads

Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Can Cytology Face the Challenge of Diagnosis in the Light of the New Classification?

Acta Cytol 2018 1;62(4):265-272. Epub 2018 Jun 1.

Objectives: To assess the cytological findings of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), conventional papillary thyroid carcinomas (C-PTC), and invasive follicular variants of papillary thyroid carcinomas (IFV-PTC) to determine if there are cytological differences between groups.

Study Design: We have reviewed all thyroid fine-needle aspiration cytology samples diagnosed between 2000 and 2017. We have included all NIFTP cases (n = 6) and randomly selected cases of C-PTC (n = 14) and IFV-PTC (n = 8). Read More

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http://dx.doi.org/10.1159/000488579DOI Listing
August 2018
9 Reads

Evaluation of the LC-1000 Flow Cytometry Screening System for Cervical Cancer Screening in Routine Health Checkups.

Acta Cytol 2018 29;62(4):279-287. Epub 2018 May 29.

MEDIcheck LAB, Korea Association of Health Promotion, Cheongju, Republic of Korea.

Objective: This study evaluated the performance of a flow cytometry system (LC-1000) in screening cervical precancerous lesions at routine health checkups.

Study Design: In total, 928 health examinees were enrolled at 16 health promotion centers in 13 Korean cities between 2016 and 2017. All participants underwent liquid-based cervical cytology and flow cytometry testing to determine the cell proliferation index (CPIx). Read More

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http://dx.doi.org/10.1159/000489079DOI Listing
August 2018
9 Reads

Does 100% Rapid Review Improve Cervical Cancer Screening?

Acta Cytol 2018 22;62(3):209-214. Epub 2018 May 22.

Federal University of Rio Grande do Norte, Natal, Brazil.

Objective: The aim of this work was to evaluate 100% rapid review (100% RR) as a useful tool to detect false negative (FN) results.

Study Design: A sample of 8,677 swabs was investigated; the unsatisfactory and negative results were referred to 100% RR, concordant results were taken as the final diagnosis, while the discordant results were debated in a consensus meeting to reach a conclusion. The positive results were examined by 2 cytologists. Read More

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http://dx.doi.org/10.1159/000488872DOI Listing
June 2018
4 Reads