653,167 results match your criteria Acta crystallographica. Section B Structural science[Journal]


Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

WPI Research Initiative for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan; Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. Electronic address:

The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold nanoparticles (GNPs) through hitherto unknown mechanisms. Here, we identified an essential role of membrane rafts in the drastic activity switching of EGF-GNPs through the following intracellular signaling. 1) In contrast to the rapid diffusion of activated EGF receptor after the soluble EGF stimulation, the receptor is confined within membrane rafts upon binding to the EGF-GNPs. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.026DOI Listing
February 2019

A transferrin receptor-binding mucoadhesive elastin-like recombinamer: in vitro and in vivo characterization.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

BIOFORGE (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, University of Valladolid, Paseo de Belén 19, 47011, Spain. Electronic address:

The development of mucoadhesive materials is of great interest and is also a major challenge. Being adsorption sites, mucosae are suitable targets for drug delivery, but as defensive barriers they are complex biological surfaces to interact with, mainly due to their protective mucus layer. As such, first- and second-generation mucoadhesives focused on material-mucus interactions, whereas the third generation of mucoadhesives introduced structural motifs that are able to interact with the cells beneath the mucus layer. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.027DOI Listing
February 2019

Toward Tissue-engineering of Nasal Cartilages.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697-2715, USA. Electronic address:

Nasal cartilage pathologies are common; for example, up to 80% of people are afflicted by deviated nasal septum conditions. Because cartilage provides the supportive framework of the nose, afflicted patients suffer low quality of life. To correct pathologies, graft cartilage is often required. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.025DOI Listing
February 2019

Effect of magnesium-degradation products and hypoxia on the angiogenesis of human umbilical vein endothelial cells.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

Institute of Materials Research, Division for Metallic Biomaterials, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany. Electronic address:

Biodegradable magnesium (Mg) metals have been applied in orthopaedic and stent applications due to their biodegradability, bioabsorbability and adaptability to tissue regeneration. However, further investigations are still needed to understand how angiogenesis will respond to high concentrations of Mg and oxygen content differences, which are vital to vascular remodelling and bone fracture regeneration or tissue healing. Human primary endothelial cells were exposed to various concentrations (2 to 8 mM) of extracellular Mg degradation products under either hypoxia or normoxia. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.018DOI Listing
February 2019

Endothelial dysfunction in pregnancy metabolic disorders.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, 8370146 Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, 8331150 Santiago, Chile. Electronic address:

In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.009DOI Listing
February 2019

Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates pathological cardiac hypertrophy through miR-155-mediated IKKi signaling.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China; Department of Cardiology, The Fifth Affiliated Hospital of Xin Jiang Medical University, Urumchi 830001, China; Qianjiang Central Hospital of Hubei Province, Qianjiang 433100, China. Electronic address:

Pathological cardiac hypertrophy, which may lead to heart failure and sudden death, can be affected by multiple factors. In our previous study, we revealed that IKKi deficiency induced cardiac hypertrophy through the activation of the AKT and NF-kB signaling pathway in response to aortic banding (AB). Non-coding RNAs, mainly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in normal developmental and pathological processes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.014DOI Listing
February 2019

Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation.

Biochim Biophys Acta Gen Subj 2019 Feb 19. Epub 2019 Feb 19.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, NE2 4HH, UK. Electronic address:

One of the main feature of chronic kidney disease is the development of renal fibrosis. Heparan Sulfate (HS) is involved in disease development by modifying the function of growth factors and cytokines and creating chemokine gradients. In this context, we aimed to understand the function of HS sulfation in renal fibrosis. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.009DOI Listing
February 2019

Iron-oxide nanoparticles target intracellular HSP90 to induce tumor radio-sensitization.

Biochim Biophys Acta Gen Subj 2019 Feb 19. Epub 2019 Feb 19.

Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India; Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400085, India. Electronic address:

Background: Nanoparticle-based therapies have emerged as a promising approach to overcome limitations of conventional chemotherapy. Present study investigates the potential of oleic acid-functionalized iron-oxide nanoparticles (MN-OA) to enhance the radiation response of fibrosarcoma tumor and elucidates its underlying mechanism.

Methods: Various cellular and molecular assays (e. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.010DOI Listing
February 2019

Ixodes ricinus infesting snakes: Insights on a new tick-host association in a Borrelia burgdorferi sensu lato endemic area.

Acta Trop 2019 Feb 19. Epub 2019 Feb 19.

Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, 70010 Valenzano, Italy. Electronic address:

The castor bean tick Ixodes ricinus is one of the most abundant tick species in Europe, being able to parasitize a wide number of vertebrate hosts, including mammals, birds, and reptiles. This tick species has an important role as vector of zoonotic pathogens, including the causative agents of Lyme borreliosis (i.e. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.021DOI Listing
February 2019

Atrial fibrillation and cardiac rehabilitation: an overview.

Acta Cardiol 2019 Feb 22:1-5. Epub 2019 Feb 22.

b Department of Cardiology , Clinique Saint Luc Bouge , Namur , Belgium.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its frequency will only continue to increase in the future. Despite available drug and electrophysical treatments, death and functional restrictions due to AF are still common. More comprehensive standards of care are therefore needed. Read More

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http://dx.doi.org/10.1080/00015385.2019.1565663DOI Listing
February 2019

Clinical outcomes of platinum-based chemotherapy plus cetuximab for recurrent or metastatic squamous cell carcinoma of the head and neck: comparison between platinum-sensitive and platinum-resistant patients.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

c Department of Head and Neck Oncology and Surgery , International University of Health and Welfare Mita Hospital , Tokyo, Japan.

Background: Combination therapy consisting of a platinum agent, 5-fluorouracil and cetuximab (EXTREME regimen) is recommended for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M-SCCHN). However, it is advisable to use platinum-free regimens as first-line therapy in patients resistant to platinum agents. There has been no report comparing EXTREME regimen outcomes between platinum-resistant and platinum-sensitive patients. Read More

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http://dx.doi.org/10.1080/00016489.2018.1551623DOI Listing
February 2019

Otitis media and mastoiditis in temporal bones of prehistoric Chilean populations. A paleopathological and paleoepidemiological study.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

f Department of Anthropology , Museo Nacional de Historia Natural , Santiago , Chile.

Background: This study evaluates otitis media in prehistoric populations in northern Chile.

Aims/objectives: Determining prevalence of otitis media and diagnostic usefulness of temporal-bone X-rays in skulls.

Materials And Methods: 444 skulls belonging to three groups: prehistoric-coastal (400-1000 AD), prehistoric-highland (400-1000 AD) and Pisagua-Regional Developments (1000-1450 AD). Read More

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http://dx.doi.org/10.1080/00016489.2018.1530800DOI Listing
February 2019

Intratympanic steroid therapy for refractory sudden sensory hearing loss: a 12-year experience with the Silverstein catheter.

Acta Otolaryngol 2019 Feb 22:1-6. Epub 2019 Feb 22.

a Department of Otorhinolaryngology , CHU Liege , Liège , Belgium.

Background: Sudden sensorineural hearing loss (SSNHL) is commonly encountered in clinical practice.

Aim/objective: Determine if local administration of corticosteroids to the inner ear can improve hearing and speech intelligibility after the failure of conventional treatment for SSNHL loss when administered for 10 days after the onset of the hearing loss in a large cohort of 77 patients.

Materials And Methods: A Silverstein MicroWick™ was placed under local anesthesia and endoscopic control in the round window niche, allowing self-administration of methylprednisolone twice daily for four weeks. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532107DOI Listing
February 2019

Incidence rate of atrial fibrillation after dialysis initiation and its relationship with cardiovascular events.

Acta Cardiol 2019 Feb 22:1-9. Epub 2019 Feb 22.

a Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital , Nagoya , Japan.

Aim: This study aimed to investigate the incidence of atrial fibrillation (AF) and its prognosis in the patients after dialysis initiation.

Methods: A total of 1524 patients with chronic kidney disease who were initiated on dialysis were included. Dialysis was initiated between October 2011 and September 2013. Read More

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http://dx.doi.org/10.1080/00015385.2018.1530085DOI Listing
February 2019

Post-operative complications of salvage total laryngectomy forpost-radiotherapy recurrent laryngeal cancer using pectoralis major myocutaneous flaps.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

a Department of Otolaryngology, Head and Neck Surgery , Tokyo Medical University , Shinjuku-ku , Tokyo , Japan.

Background: Salvage surgery for laryngeal cancer recurring after radiotherapy is difficult and complications readily occur. Our institution has adopted the pharyngeal interposition graft (PIG) using a pectoralis major myocutaneous (PMMC) flap, which has copious blood flow, for preventing post-irradiation pharyngocutaneous fistula.

Aims/objectives: The purpose of this study was to examine the incidence of post-operative complications of salvage total laryngectomy (STL) using the PMMC flap for post-radiotherapy recurrent laryngeal cancer at our institution. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532108DOI Listing
February 2019

Extracranial internal carotid artery tortuosity may cause vocal cord palsy.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

c Department of Otorhinolaryngology and Maxillofacial Surgery, Sjaellands Universitetshospital Køge , Køge , Denmark.

Background: Clinical practice made us suspect that vocal cord palsy (VCP) can be associated with extracranial internal carotid artery (ICA) tortuosity.

Objectives: To find evidence for a causative relation between ICA tortuosity and VCP.

Methods: This single-center, retrospective study comprised 66 patients with VCP. Read More

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http://dx.doi.org/10.1080/00016489.2018.1554263DOI Listing
February 2019

TLR5 and TLR7 are differentially expressed in human papillomavirus-positive and negative base of tongue squamous cell carcinoma, and TLR7 may have an independent prognostic influence.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

a Department of Oncology-Pathology , Karolinska Institute, CCK , Stockholm , Sweden.

Background: Human papillomavirus-positive (HPV) base of tongue squamous cell carcinoma (BOTSCC) has a better outcome than corresponding HPV cancer. TLR5 and TLR7 expression was previously shown to differ depending on HPV - status and correlate with outcome in oropharyngeal squamous cell carcinoma.

Aims/objectives: For validation, TLR5 and TLR7 were analyzed in a BOTSCC-cohort for correlation with HPV, survival, CD4 and CD8 tumor-infiltrating lymphocyte (TIL) counts, the latter being a well-documented prognostic marker. Read More

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http://dx.doi.org/10.1080/00016489.2018.1552014DOI Listing
February 2019

Assessment of preoperative psychologic distress in laryngeal cancer patients.

Acta Otolaryngol 2019 Feb 22:1-3. Epub 2019 Feb 22.

a Department of Anaesthesiology, The Eye Ear Nose and Throat Hospital , Fudan University , Shanghai , China.

Background: Preoperative psychologic distress is common in head and neck cancer patients and related to deleterious effects in patient treatment and recovery. Routine screening and appropriate referral of all patients with cancer for psychiatric assessment is now a part of the medical treatment.

Objects: The aim was to assess the level of preoperative psychologic distress in laryngeal cancer patients scheduled for surgical treatment. Read More

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http://dx.doi.org/10.1080/00016489.2018.1523555DOI Listing
February 2019

Anatomical study of presigmoid-retrolabyrinthine approach based on temporal bone high-resolution CT.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

b Department of Radiology , Beijing Tongren Hospital, Affiliate of Capital Medical , Beijing , China.

Background: The surgical approach of acoustic neuroma includes translabyrinthine, transcranial fossa, suboccipital retrosigmoid sinus, and presigmoid retrolabyrinthine approach. Aims/Objective: To provide the anatomical basis for the surgical selection of presigmoid retrolabyrinthine approach by measuring the anatomical parameters of retrolabyrinthine space of the petrous bone by high-resolution CT.

Material And Methods: A retrospective study of 208 high-resolution CT (HRCT) images of 104 patients examined in our hospital were analyzed retrospectively. Read More

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http://dx.doi.org/10.1080/00016489.2018.1550585DOI Listing
February 2019

Prospective multi-center study on expansion sphincter pharyngoplasty.

Acta Otolaryngol 2019 Feb 22:1-4. Epub 2019 Feb 22.

d Department of Otolaryngology , Asia Sleep Centre, Paragon Medical Centre , Singapore.

Background And Objective: The aim of this study was to demonstrate the long-term effectiveness of Expansion Sphincter Pharyngoplasty (ESP) as a standalone surgical treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients through a prospective multi-center study.

Material And Methods: A prospective non-comparative multicenter study of patients suffering from OSHAS selected after drug-induced sleep endoscopy, with ESP as standing alone procedure was performed. Inclusion criteria were lateral collapse on oropharynx and preoperative AHI between 5 and 70. Read More

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http://dx.doi.org/10.1080/00016489.2018.1533992DOI Listing
February 2019

Prediction models for determining the success of labor induction: a systematic review.

Acta Obstet Gynecol Scand 2019 Feb 22. Epub 2019 Feb 22.

University of Toronto, Toronto, Canada.

Introduction: The purpose of this study was to systematically identify and compare clinical models using universally accessible clinical and demographic factors, which have been derived and/or validated to predict the success of labor induction with a view to making recommendations for practice.

Material And Methods: MEDLINE, Embase, www.clinicaltrials. Read More

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http://dx.doi.org/10.1111/aogs.13589DOI Listing
February 2019

Vaginal or laparoscopic hysterectomy: do peri-operative outcomes differ? A propensity score matched analysis.

Acta Obstet Gynecol Scand 2019 Feb 22. Epub 2019 Feb 22.

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.

Introduction: There are assertions that vaginal mode may be the preferred approach of minimally invasive hysterectomy; yet rates of laparoscopic hysterectomy continue to rise while vaginal hysterectomy rate remains relatively unchanged. The aim of this study is to compare the peri-operative outcomes of laparoscopic versus vaginal hysterectomy.

Material And Methods: We identified women who underwent either laparoscopic or vaginal hysterectomy for benign indications between 2009 and 2015 at a large academic institution. Read More

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http://dx.doi.org/10.1111/aogs.13591DOI Listing
February 2019

Identification of six novel factor viii gene variants using next generation sequencing and molecular dynamics simulation.

Acta Biochim Pol 2019 Feb 22. Epub 2019 Feb 22.

1Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia; 2Science and Technology Unit, Umm Al Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia.

Hemophilia A is an X-linked recessive hemorrhagic disorder caused by variants in the F8 gene. To identify known and novel causative variants in hemophilia A, we have carried out genetic analysis among Saudi patients. Twenty-one patients, who were negative for inv-1/inv-22, were selected for analysis by next generation sequencing, thereafter confirmed by Sanger sequencing. Read More

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http://dx.doi.org/10.18388/abp.2018_2339DOI Listing
February 2019

Prognostic value of broad-spectrum keratin clones AE1/AE3 and CAM5.2 in small cell lung cancer patients undergoing pulmonary resection.

Acta Biochim Pol 2019 Feb 22. Epub 2019 Feb 22.

7Department of Oncology and Radiotherapy, Medical University of Gdansk, Poland.

Introduction: Small cell lung carcinoma (SCLC) is an aggressive pulmonary neoplasm of neuroendocrine origin. Keratins form a large group of intermediate filaments, which are major structural proteins in epithelial cells and carcinomas. SCLC shows a wide spectrum of keratin expression, from very strong to completely negative. Read More

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http://dx.doi.org/10.18388/abp.2018_2773DOI Listing
February 2019

National guidelines and multilingual age-adapted patient brochures and videos as decision aids for fertility preservation of children and teenagers with cancer - A multidisciplinary effort to improve children's information and access to fertility preservation in Sweden.

Acta Obstet Gynecol Scand 2019 Feb 21. Epub 2019 Feb 21.

Institute of Clinical Sciences, Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Despite several evidence-based guidelines available to promote fertility preservation (FP) for young patients and children, young patients still report FP as one of the top five unmet needs during their cancer care. Surveys have identified barriers that limit patients' access to FP, including organization-related barriers, such as lack of inter-professional cooperation, unclear referral paths for FP and the cost of the procedures. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/aogs.13588DOI Listing
February 2019

MUL1 Gene Polymorphisms And Parkinson's Disease Risk.

Acta Neurol Scand 2019 Feb 22. Epub 2019 Feb 22.

Neurology Department of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, PR China.

Objectives: Parkinson's disease (PD) is afflicting millions of patients worldwide, and gene therapy may be a hope for cure. Recent researches have shown that MUL1 may play a key role in PD pathogenesis, but no specific genetic variants has been identified. This study was aimed to verify the hypothesis that variants in MUL1 gene were associated with PD risk in a Chinese cohort. Read More

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http://dx.doi.org/10.1111/ane.13081DOI Listing
February 2019

Immunohistochemical predictive markers of response to conservative treatment of endometrial hyperplasia and early endometrial cancer: a systematic review.

Acta Obstet Gynecol Scand 2019 Feb 21. Epub 2019 Feb 21.

Gynecology and Obstetric Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Introduction: Progestogens are widely used for the conservative treatment of endometrial hyperplasia and early endometrial cancer. Nevertheless, they do not achieve the regression in all cases. Although several immunohistochemical markers have been assessed in order to predict the response to treatment, their usefulness is still unclear. Read More

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http://dx.doi.org/10.1111/aogs.13587DOI Listing
February 2019

Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats.

Acta Pharmacol Sin 2019 Feb 21. Epub 2019 Feb 21.

Center of Drug Metabolism and Pharmacokinetics, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.

Cinnamic acid and its analogues (pyragrel and ozagrel) undergo chain-shortened (β-oxidative) and reductive metabolism on acyl side chain. In this study, we characterized the β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues using primary rat hepatocytes, hepatic mitochondrial, and microsomal systems. A compartmental model including parent compounds and metabolites was developed to characterize in vivo β-oxidative and reductive metabolism following an intravenous dose of parent compounds to rats. Read More

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http://dx.doi.org/10.1038/s41401-019-0218-8DOI Listing
February 2019

Minocycline protects against myocardial ischemia/reperfusion injury in rats by upregulating MCPIP1 to inhibit NF-κB activation.

Acta Pharmacol Sin 2019 Feb 21. Epub 2019 Feb 21.

Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 510182, China.

Minocycline is a tetracycline antibiotic and has been shown to play a protective role in cerebral and myocardial ischemia/reperfusion (I/R). However, the underlying mechanism remains unclear. Herein, we investigated whether monocyte chemotactic protein-induced protein-1 (MCPIP1), a negative regulator of inflammation, was involved in the minocycline-induced cardioprotection in myocardial I/R in vivo and in vitro models. Read More

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http://dx.doi.org/10.1038/s41401-019-0214-zDOI Listing
February 2019

The power of metabolism - Linking energy supply and demand with cardiac contractile function.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 18. Epub 2019 Feb 18.

Maastricht University, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.02.006DOI Listing
February 2019

Transformation Products of Organic Contaminants and Residues-Overview of Current Simulation Methods.

Molecules 2019 Feb 19;24(4). Epub 2019 Feb 19.

Department of Analytical Chemistry and Reference Materials, Bundesanstalt für Materialforschung und-prüfung (BAM), Richard-Willstätter-Straße 11, 12489 Berlin, Germany.

The formation of transformation products (TPs) from contaminants and residues is becoming an increasing focus of scientific community. All organic compounds can form different TPs, thus demonstrating the complexity and interdisciplinarity of this topic. The properties of TPs could stand in relation to the unchanged substance or be more harmful and persistent. Read More

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http://dx.doi.org/10.3390/molecules24040753DOI Listing
February 2019

Parental reports showed that snoring in infants at three and eight months associated with snoring parents and smoking mothers.

Acta Paediatr 2019 Feb 21. Epub 2019 Feb 21.

Pediatric Research Center, Child Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Aim: This prospective study examined the prevalence of snoring during infancy and the prenatal and postnatal risk factors for this condition.

Methods: The study population comprised 1,388 infants from the CHILD-SLEEP birth cohort, who were recruited in the Pirkanmaa Hospital District, Finland, between 2011 and 2013. Sleep and background factor questionnaires were filled out prenatally by parents and when the infant was three and eight months old. Read More

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http://dx.doi.org/10.1111/apa.14758DOI Listing
February 2019

Sequence- and seed-structure-dependent polymorphic fibrils of alpha-synuclein.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 18. Epub 2019 Feb 18.

Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science, 1-3 Miyakodanitatara, Kyotanabe-shi, Kyoto 610-0394, Japan. Electronic address:

Synucleinopathies comprise a diverse group of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. These share a common pathological feature, the deposition of alpha-synuclein (a-syn) in neurons or oligodendroglia. A-syn is highly conserved in vertebrates, but the primary sequence of mouse a-syn differs from that of human at seven positions. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.013DOI Listing
February 2019

Role of container type, behavioural, and ecological factors in Aedes pupal production in Dhaka, Bangladesh: An application of zero-inflated negative binomial model.

Acta Trop 2019 Feb 18. Epub 2019 Feb 18.

University of Manitoba, Natural Resources Institute, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.actatropica.2019.02.019DOI Listing
February 2019

MALDI-TOF mass spectrometry distinguishes daratumumab from M-proteins.

Clin Chim Acta 2019 Feb 18. Epub 2019 Feb 18.

Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 327 E. 64th St., New York, NY 10065, United States of America. Electronic address:

Background: Daratumumab, a therapeutic IgG kappa monoclonal antibody, can cause a false positive interference on electrophoretic assays that are routinely used to monitor patients with monoclonal gammopathies. In this study, we evaluate the ability of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to distinguish daratumumab from disease-related IgG kappa monoclonal proteins (M-protein).

Methods: Waste clinical samples from 31 patients who were receiving daratumumab and had a history of IgG kappa monoclonal gammopathy were collected. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.017DOI Listing
February 2019

Epidemiological variations and trends in health burden of glaucoma worldwide.

Acta Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.

Purpose: To evaluate the trends and variations in global health burden of glaucoma by year, age and sex, region and socio-economic status, using disability-adjusted life years (DALYs).

Method: The DALY numbers, crude DALY rate and age-standardized DALY rate globally and in each country were obtained the GBD 2015 study database. The corresponding human development index (HDI) and gross domestic product (GDP) per capita were obtained from the United Nations and World Bank. Read More

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http://dx.doi.org/10.1111/aos.14044DOI Listing
February 2019

The effects of the PRISMA statement to improve the conduct and reporting of systematic reviews and meta-analyses of nursing interventions for patients with heart failure.

Int J Nurs Pract 2019 Feb 20:e12729. Epub 2019 Feb 20.

Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, China.

Aims: The study aims to evaluate the reporting and methodological quality of systematic reviews and meta-analyses on nursing interventions in the field of heart failure and investigate whether reporting and methodological quality has been improved after PRISMA statement was published.

Methods: Pubmed, Cochrane Database of Systematic Review, and Embase databases were searched from inception of databases to July 31, 2018. Two authors independently extracted data from October 1, 2018, to October 31, 2018. Read More

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http://dx.doi.org/10.1111/ijn.12729DOI Listing
February 2019

Parenting style associations with sensory threshold and behavior, a prospective cohort study in term/preterm infants.

Acta Paediatr 2019 Feb 20. Epub 2019 Feb 20.

Nationwide Children's Hospital & The Ohio State University, Columbus, OH.

Aim: Early-life atypical sensory functioning and behavioral profiles are often associated with long-term developmental problems, especially in former preterm infants. We tested whether parenting style is associated with atypical sensory threshold or behavioral outcomes in preterm and term infants assessed during early childhood.

Methods: We prospectively evaluated parenting style for a cohort of term and preterm infants who had previous assessments of sensory development and behavior. Read More

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http://dx.doi.org/10.1111/apa.14761DOI Listing
February 2019

MicroRNAs in contusion spinal cord injury: pathophysiology and clinical utility.

Acta Neurol Belg 2019 Feb 21. Epub 2019 Feb 21.

Department of Rehabilitation Medicine, Peking University Third Hospital, 49 North Garden Road, Beijing, 100191, People's Republic of China.

Spinal cord injury (SCI) in humans is a common central nervous system trauma. Pathophysiologically, SCI involves both primary and secondary damages. Therapeutically, targeting secondary damage including inflammation, neuropathic pain, apoptosis, demyelination, and glial reaction to promote functional benefits for SCI patients has long been considered a potential treatment strategy by neuroscientists and clinicians. Read More

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http://dx.doi.org/10.1007/s13760-019-01076-9DOI Listing
February 2019

Hemorrhagic burden in poor-grade aneurysmal subarachnoid hemorrhage: a volumetric analysis of different bleeding distributions.

Acta Neurochir (Wien) 2019 Feb 21. Epub 2019 Feb 21.

Department of Neuroradiology, Interventional Neuroradiology Division, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy.

Background: Volumetric assessment of aneurysmal bleeding has been evaluated in few studies and emerged as a promising outcome predictor. There is a lack of studies evaluating its impact in the poor-grade population.

Methods: Retrospective review of 63 consecutive poor-grade aneurysmal subarachnoid hemorrhage (aSAH) patients, defined as grade IV and V according to the World Federation of Neurological Surgeons (WFNS) classifications. Read More

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http://dx.doi.org/10.1007/s00701-019-03846-zDOI Listing
February 2019

Fraction of anisotropy and apparent diffusion coefficient as diagnostic tools in trigeminal neuralgia.

Acta Neurochir (Wien) 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurosurgery, Faculty of Medicine, Federal University of Ceará, 100, Avenida Comandante Maurocelio Rocha Pontes, Sobral, 62042-280, Brazil.

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http://dx.doi.org/10.1007/s00701-019-03852-1DOI Listing
February 2019

Lausanne checklist for safe stereotactic radiosurgery.

Acta Neurochir (Wien) 2019 Feb 21. Epub 2019 Feb 21.

Centre Hospitalier Universitaire Vaudois, Neurosurgery Service and Gamma Knife Center, Lausanne University Hospital (CHUV), Rue du Bugnon 44-46, BH-08, CH-1011, Lausanne, Switzerland.

Introduction: Stereotactic radiosurgery (SRS) is increasingly used as a minimally invasive alternative in many neurosurgical conditions, including benign and malignant tumors, vascular malformations, and functional procedures. As for any surgical procedure, strict safety guidelines and checklists are necessary to avoid errors and the inherent unnecessary complications. With regard to the former, other groups have already reported human and/or technical errors. Read More

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http://dx.doi.org/10.1007/s00701-019-03843-2DOI Listing
February 2019

Chronic subdural cortical stimulation for phantom limb pain: report of a series of two cases.

Acta Neurochir (Wien) 2019 Feb 21. Epub 2019 Feb 21.

Departments of Neurologic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.

Phantom limb pain is a complex, incompletely understood pain syndrome that is characterized by chronic painful paresthesias in a previous amputated body part. Limited treatment modalities exist that provide meaningful relief, including pharmacological treatments and spinal cord stimulation that are rarely successful for refractory cases. Here, we describe our two-patient cohort with recalcitrant upper extremity phantom limb pain treated with chronic subdural cortical stimulation. Read More

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http://dx.doi.org/10.1007/s00701-019-03828-1DOI Listing
February 2019

Adjuvant radiotherapy after local excision of rectal cancer.

Acta Oncol 2019 Feb 21:1-5. Epub 2019 Feb 21.

a Department of Colorectal Surgery , Oxford University Hospitals , Oxford , UK.

Background: Local excision is now accepted as a standard treatment option for certain patients with early rectal cancer. However, there is a higher risk of local recurrence than after radical surgery with total mesorectal excision. Adjuvant radiotherapy after local excision may reduce this excess risk, and yet retain the benefits of local excision, with rectal preservation. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1578895DOI Listing
February 2019

Maternal perception about child oral health is associated to child dental caries and to maternal self-report about oral health.

Acta Odontol Scand 2019 Feb 21:1-5. Epub 2019 Feb 21.

a Post-Graduate Program of Dentistry, Federal University of Pelotas , Pelotas , Brazil.

Objective: To test the association between maternal perception about child's oral health and child dental caries experience and maternal self-perception about oral health.

Materials And Methods: A cross-sectional study was performed with mothers and their children aged six to 13 years. A questionnaire was applied to mothers. Read More

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http://dx.doi.org/10.1080/00016357.2019.1570332DOI Listing
February 2019

An interesting case of wide QRS tachycardia with left bundle branch block morphology.

Acta Cardiol 2019 Feb 21:1-2. Epub 2019 Feb 21.

a Department of Cardiology , Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram , Kerala , India.

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http://dx.doi.org/10.1080/00015385.2018.1527075DOI Listing
February 2019

Clinical outcomes of end-flexible-rigidscopic transoral surgery (E-TOS) in patients with T1-selected T3 pharyngeal and supraglottic cancers.

Acta Otolaryngol 2019 Feb 21:1-8. Epub 2019 Feb 21.

a Otolaryngology-Head & Neck Surgery , Osaka Red Cross Hospital , Osaka , Japan.

Background: Endoscopic laryngo-pharyngeal surgery (ELPS), which is a transoral minimally invasive surgery using a gastrointestinal endoscope and a curved laryngopharyngeal retractor, is effective to treat primary lesions of superficial laryngopharyngeal cancers. To extend concepts of ELPS to invasive laryngopharyngeal cancers, we developed end-flexible-rigidscopic transoral surgery (E-TOS) from ELPS by changing a gastrointestinal endoscope to a flexible-tip rigid endoscope.

Aims/objectives: To retrospectively evaluate oncological outcomes and laryngopharyngeal functional preservation of E-TOS in patients with T1-selected T3 laryngopharyngeal cancers. Read More

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http://dx.doi.org/10.1080/00016489.2018.1532106DOI Listing
February 2019

School performance is age-appropriate with support services in very preterm children at 11 years of age.

Acta Paediatr 2019 Feb 20. Epub 2019 Feb 20.

Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Aim: This Finnish regional birth-cohort study compared the school performance of very preterm and full-term children when they reached 11 years of age.

Methods: Teachers rated the educational abilities of 123 preterm children and 133 full-term controls at the age of 11 years as well as the support services they received. The children were all born in the Turku University Hospital between 2001 and 2005. Read More

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http://dx.doi.org/10.1111/apa.14763DOI Listing
February 2019

Abnormal neurological soft signs in babies born to smoking mothers were associated with lower breastfeeding for first three months.

Acta Paediatr 2019 Feb 20. Epub 2019 Feb 20.

Department of Neurosciences, Psychology, Drug Research and Child Health, Careggi University Hospital of Florence, Italy.

Aim: We examined associations between neurological alterations in infants born to smoking mothers and breastfeeding success at discharge and three months of age.

Methods: This 2016 study compared 35 normal weight infants born to smoking mothers at 37-41 weeks and 35 matched controls born to non-smoking mothers at the Maternity Hospital of Careggi University, Florence, Italy. Neonatal behaviour was evaluated using the neurological soft signs (NSS) component of the Graham-Rosenblith Scale. Read More

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http://dx.doi.org/10.1111/apa.14762DOI Listing
February 2019
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