650,262 results match your criteria Acta crystallographica. Section B Structural science[Journal]


A novel OFF-ON-OFF fluorescence probe based on coumarin for Al and F detection and bioimaging in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 11;211:299-305. Epub 2018 Dec 11.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.

A novel fluorescence probe L2 based on coumarin has been designed and synthesized. The probe L2 can be used for relay recognition of metal ions Al and anion F in the aqueous HEPES buffer (0.05 M, pH = 7. Read More

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http://dx.doi.org/10.1016/j.saa.2018.12.022DOI Listing
December 2018

Fabrication of a nanomaterial-based fluorescence sensor constructed from ligand capped CdTe quantum dots for ultrasensitive and rapid detection of silver ions in aqueous samples.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 10;211:291-298. Epub 2018 Dec 10.

Department of Chemistry, Payame Noor University, P.O.BOX: 19395-3697, Tehran, Iran. Electronic address:

In this study, CdTe QDs were prepared in aqueous medium and then capped with a synthetic heterocycle ligand (CdTe/L QDs) via surface modification method. Characterization of synthesized CdTe/L QDs was carried out through various analytical techniques including fluorescence spectroscopy, transmission electron microscopy (TEM), UV-Vis spectrophotometry, thermo-gravimetric (TG) analysis and Fourier transform infrared (FTIR). The fluorescence intensity of the CdTe/L QDs at 520 nm (excitation at 380 nm) was selectively quenched in the presence of trace amounts of silver ions. Read More

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http://dx.doi.org/10.1016/j.saa.2018.12.016DOI Listing
December 2018

Rapid detection of TNP based on a commercial fluorescent probe.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 10;211:287-290. Epub 2018 Dec 10.

Collaborative Innovation Center of Judicial Civilization, China; Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing 100088, China; People's Public Security University of China, Beijing 100038, China. Electronic address:

A simple, rapid and low cost sensing method for the fluorescent detection of TNP in 100% aqueous media was successfully developed based on a commercial probe. Under the non-covalent interactions between TNP with probe, a ratiometric output signal was achieved, which can be applied in real samples test. Read More

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http://dx.doi.org/10.1016/j.saa.2018.12.014DOI Listing
December 2018

Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 15. Epub 2018 Dec 15.

Dept. of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China; Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

Acute kidney injury (AKI) is a frequent complication of sepsis and contributes to increased morbidity and mortality. Urinary tissue inhibitor of metalloproteinases-2 (TIMP2) has been recently recognized as an early biomarker to predict AKI in critically ill patients. However, the biological functions of TIMP2 remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.10.041DOI Listing
December 2018

Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 15. Epub 2018 Dec 15.

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China. Electronic address:

Roux-en-Y Gastric Bypass (RYGB) remains one of the most effective options in treatment of non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms are not clear yet. Here, we evaluated the relationship among hepatic mechanistic target of rapamycin (mTOR)-AKT2-insulin-induced gene 2 (Insig2) signaling, lipogenic transcription factors and lipid synthesis enzymes in obese mice with or without RYGB operation. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.12.014DOI Listing
December 2018

A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E.

Biochim Biophys Acta Biomembr 2018 Dec 15. Epub 2018 Dec 15.

Department of Biophysical Chemistry, Kyoto Pharmaceutical University, 5 Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan. Electronic address:

In the direct cell membrane penetration, arginine-rich cell-penetrating peptides are thought to penetrate into cells across the hydrophobic lipid membranes. To investigate the effect of the amphipathic property of arginine-rich peptide on the cell-penetrating ability, we designed a novel amphipathic cell-penetrating peptide, A2-17, and its derivative, A2-17KR, in which all lysine residues are substituted with arginine residues, based on the glycosaminoglycan binding region in the N-terminal α-helix bundle of human apolipoprotein E. Isothermal titration calorimetry showed that A2-17 variants have a strong ability to bind to heparin with high affinity. Read More

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http://dx.doi.org/10.1016/j.bbamem.2018.12.010DOI Listing
December 2018

Carborane derivatives of 1,2,3-triazole depolarize mitochondria by transferring protons through the lipid part of membranes.

Biochim Biophys Acta Biomembr 2018 Dec 15. Epub 2018 Dec 15.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation. Electronic address:

Boron containing polyhedra (carboranes) are three-dimensional delocalized aromatic systems. These structures have been shown to transport protons through lipid membranes and mitochondria. Conjugation of carboranes to various organic moieties is aimed at obtaining biologically active compounds with novel properties. Read More

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http://dx.doi.org/10.1016/j.bbamem.2018.12.009DOI Listing
December 2018

TNFRSF11B: A potential plasma biomarker for diagnosis of obstructive sleep apnea.

Clin Chim Acta 2018 Dec 15. Epub 2018 Dec 15.

Department of Otolaryngology Head & Neck Surgery, Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Obstructive sleep apnea (OSA) was characterized by chronic intermittent hypoxia, which was an independent risk factor for endothelial dysfunction. Circulating TNFRSF11B might play an important role in promoting endothelial cells dysfunction. We explored the role of plasma TNFRSF11B as a potential mechanism of endothelial dysfunction in OSA patients. Read More

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http://dx.doi.org/10.1016/j.cca.2018.12.017DOI Listing
December 2018

WDP formulations using a novel mosquitocidal bacteria, Bacillus thuringiensis subsp. israelensis/tochigiensis (VCRC B-474) - Development and storage stability.

Acta Trop 2018 Dec 15. Epub 2018 Dec 15.

Vector Control Research Centre (Indian Council of Medical Research), Indira Nagar, Pondicherry, 605006, India. Electronic address:

A novel mosquito active strain, Bacillus thuringiensis (VCRC B474) sharing the antigens of 2 serotypes, namely israelensis &tochigiensis was characterized by scanning electron microscopy and SDS-PAGE. The spherical and ovoid crystals present in this strain was composed of major polypeptides the size of 28, 65, and 130 kDa respectively. The sporulated cell mass was formulated into water dispersible powder (WDP) formulations with different carrier materials and checked for activity against Culex quinquefasciatus larvae at monthly intervals for up to a year. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.12.023DOI Listing
December 2018

Telephone reminders reduced non-attendance rates in a paediatric outpatient department.

Acta Paediatr 2018 Dec 18. Epub 2018 Dec 18.

Department of Paediatrics, Kolding Hospital - a part of Lillebaelt Hospital.

Missed hospital appointments increase health costs, make the healthcare systems less effective and can delay diagnoses and treatments. Studies have shown that providing reminders by letter, texts or telephone calls decreased non-attendance rates. The paediatric outpatient clinic at Kolding Hospital, Denmark, experienced an increasing number of late cancellations and no-shows, despite sending automated texts 48 hours before appointments. Read More

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http://dx.doi.org/10.1111/apa.14701DOI Listing
December 2018

Skin-to-skin contact during eye examination did not reduce pain compared to standard care with parental support in preterm infants.

Acta Paediatr 2018 Dec 18. Epub 2018 Dec 18.

Department of Neuromedicine and Movement Science (INB), Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Aim: We compared the pain relieving effect of skin-to-skin contact versus standard care in the incubator during screening for retinopathy of prematurity.

Methods: This randomised crossover study included 35 preterm infants of less than 32 weeks of gestational age admitted to St Olavs University Hospital, Trondheim, Norway, between January 2014 and June 2016. Randomisation was for skin-to-skin with one of the parents or standard care with supportive positioning by parents for the first of two consecutive eye examinations. Read More

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http://dx.doi.org/10.1111/apa.14699DOI Listing
December 2018

Hysterectomy-Should all residents learn to perform it?

Acta Obstet Gynecol Scand 2019 Jan;98(1):5-6

Department of Obstetrics and Gynecology, Onze Lieve Vrouwe Gasthuis (OLVG, Our Lady's Guest House Hospital), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/aogs.13507DOI Listing
January 2019

Depression Precedes, But Does Not Follow, Gestational Diabetes.

Acta Psychiatr Scand 2018 Dec 18. Epub 2018 Dec 18.

Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences.

Objectives: To determine whether past history of depression is associated with increased rates of gestational diabetes, and whether history of gestational diabetes is associated with increased rates of postpartum depression.

Research Design: Data for this case-control study consisted of deidentified chart records for 1,439 women who received pregnancy care at a large university hospital between 1998 and 2017.

Results: A history of depression prior to pregnancy was associated with gestational diabetes requiring insulin, although not with subtler degrees of gestational hyperglycemia. Read More

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http://dx.doi.org/10.1111/acps.12998DOI Listing
December 2018

Risk of tumor implantation in percutaneous endoscopic gastrostomy in the upper aerodigestive tumors.

Acta Biomed 2018 Dec 17;89(8-S):117-121. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Percutaneous endoscopic gastrostomy (PEG) has become a mainstay in providing enteral access for patients with obstructive head, neck and esophageal tumors. Tumor cell implantation is a rare complication in patients with aerodigestive cancers, who have undergone PEG tube placement. The objective of this review is to determine the incidence and contributing risk factors leading to the implantation of metastases into the abdominal wall following PEG placement. Read More

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December 2018

Advanced gastric cancer: the value of surgery.

Acta Biomed 2018 Dec 17;89(8-S):110-116. Epub 2018 Dec 17.

Emergency, General and Trauma Surgery dept., Bufalini hospital, Cesena, Italy.

Gastric cancer is a common disease with high mortality. The definition of advanced gastric cancer is still debated. Radical surgery associated to appropriate systemic and intra-abdominal chemotherapy is the gold standard treatment. Read More

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December 2018

Advanced gastric cancer: the value of systemic and intraperitoneal chemotherapy.

Acta Biomed 2018 Dec 17;89(8-S):104-109. Epub 2018 Dec 17.

Emergency, General and Trauma Surgery dept., Bufalini hospital, Cesena, Italy.

Several possibilities in treating advanced gastric cancer exist. Radical surgery associated with chemotherapy represents the cornerstone. Which one is more effective among neoadjuvant, adjuvant or perioperative chemotherapy is still a matter of debate. Read More

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December 2018

Autoimmune diseases in autoimmune atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):100-103. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus. Read More

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December 2018

From Sidney to OLGA: an overview of atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):93-99. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Chronic gastritis is a long-lasting disease that can lead to a loss of appropriate gastric glands. Gastritis, as term, apply to an inflammation of the stomach, histologically proven, sometimes with structural mucosal changes. Worldwide Helicobacter pylori's infection play a pivotal role as the main etiological effector of chronic active gastritis. Read More

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December 2018

Clinical manifestations of chronic atrophic gastritis.

Acta Biomed 2018 Dec 17;89(8-S):88-92. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors. Read More

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December 2018

Epidemiology of gastric cancer and risk factors.

Acta Biomed 2018 Dec 17;89(8-S):82-87. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Gastric cancer is, still nowadays, an important healthcare problem worldwide. In Italy, it represents the fifth tumour by frequency in both men and women over 70 years old. A crucial point is represented by the percentage of early gastric cancers usually found, which is actually very low, and it carries to a worse morbidity and mortality. Read More

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December 2018

Usefulness of intraoperative endoscopy in pediatric surgery: state of the art.

Acta Biomed 2018 Dec 17;89(8-S):77-81. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Introduction: Intraoperative endoscopy is a procedure that supports open and laparoscopic surgery, helping the surgeon to identify the presence of endoluminal gastrointestinal lesions which need to be treated, with a correct diagnosis and an adequate therapy.

Material And Methods: A search on PubMed was performed using "intraoperative esophagoscopy", "intraoperative duodenoscopy", and "intraoperative enteroscopy" as Mesh terms. The applied exclusion criteria were: papers written before 2000, not concerning pediatric or gastrointestinal pathology, literature-review articles, language different from English. Read More

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December 2018

Helicobacter pylori, transmission routes and recurrence of infection: state of the art.

Acta Biomed 2018 Dec 17;89(8-S):72-76. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Helicobacter pylori (H. pylori) infection is one of the most common infection in humans, affecting more than half of the population. The prevalence of the infection varies widely in rural developing areas (more than 80%) compared to urban developed ones (less than 40%), as a consequence of different socioeconomic and hygienic conditions. Read More

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December 2018

How and when investigating and treating Helicobacter pylori infection in children.

Acta Biomed 2018 Dec 17;89(8-S):65-71. Epub 2018 Dec 17.

Azienda USL of Reggio Emilia-IRCCS, Maternal and Child Department, Pediatric Unit, Sant'Anna Hospital, Castelnovo ne' Monti, Reggio Emilia, Italy.

For thousands of years humans have lived in symbiosis with Helicobacter pylori. This infection is acquired mainly during childhood and, despite it represents one of the most common infections in humans, only a minority of infected people may develop health issues and life-threatening diseases. For diagnosing Helicobacter pylori infection in children we can use, at first, non-invasive diagnostic tests, if clinical pattern and/or history are of suspicion. Read More

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December 2018

Non-invasive tests for the diagnosis of helicobacter pylori: state of the art.

Acta Biomed 2018 Dec 17;89(8-S):58-64. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Usually, non-invasive tests are the first methods for diagnosing Helicobacter pylori (HP) infection. Among these, serological test, stool antigen research and urea breath test are the most used. Antibodies anti-HP are not recommended in low prevalence population, moreover they cannot reveal an ongoing infection, but they only prove a contact with the bacterium. Read More

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December 2018

Non-invasive method for the assessment of gastric acid secretion.

Acta Biomed 2018 Dec 17;89(8-S):53-57. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Methods for the measure of gastric acid secretion include invasive and non-invasive tests. The gold-standard to measure the acid output is the collection of gastric after in basal condition (Basal Acid Output, B.A. Read More

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December 2018

A non-invasive method for the diagnosis of upper GI diseases.

Acta Biomed 2018 Dec 17;89(8-S):40-43. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Upper-GI diseases are one of the most relevant issue in primary care. Nowadays they are still responsible for about 100 million ambulatory care visits only in the US. The diagnosis of almost every upper-GI condition is still deputed to invasive tests such as upper gastrointestinal endoscopy, gastroesophageal manometry or radiography. Read More

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December 2018

Relationship between Helicobacter pylori infection and GERD.

Acta Biomed 2018 Dec 17;89(8-S):40-43. Epub 2018 Dec 17.

Dipartimento di Medicina e Chirurgia, Università degli Studi di Parma.

Gastroesophageal reflux disease (GERD) is due to the chronic exposure of the esophageal mucosa to acid secretion from the stomach. Helicobacter pylori (H.p. Read More

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December 2018

Diagnosis of GERD in typical and atypical manifestations.

Acta Biomed 2018 Dec 17;89(8-S):33-39. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

The manifestations of gastroesophageal reflux disease (GERD) have been recently classified into either esophageal or extra-esophageal syndromes. Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD. Endoscopy had a low sensitivity. Read More

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December 2018

Endoscopic dilation in pediatric esophageal strictures: a literature review.

Acta Biomed 2018 Dec 17;89(8-S):27-32. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background: Esophageal strictures in pediatric age are a quite common condition due to different etiologies. Esophageal strictures can be divided in congenital, acquired and functional. Clinical manifestations are similar and when symptoms arise, endoscopic dilation is the treatment of choice. Read More

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December 2018

Eosinophilic esophagitis in pediatric age, state of the art and review of the literature.

Acta Biomed 2018 Dec 17;89(8-S):20-26. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Eosinophilic esophagitis (EoE) is a chronic immune-mediated relapsing disease caused by eosinophilic infiltration of the esophageal mucosa which is normally lacking these cells. EoE belongs to the group of the so called Eosinophilic Gastrointestinal Disorders (EGIDs). From a rare and unusual disease, EoE has become an emerging entity and in recent years its incidence and prevalence have increased all over the world, also in children. Read More

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December 2018

Clinical approach to the patient with acute gastrointestinal bleeding.

Acta Biomed 2018 Dec 17;89(8-S):12-19. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Gastrointestinal bleeding (GIB) is a very common condition at all ages, with high rates of morbidity and mortality, especially in case of acute presentation. The optimal management of acute GIB requires a timely overview of vital signs and clinical presentation to stabilize the patient if necessary and set up the most adequate diagnostic and therapeutic approach, based on the suspected etiology. Endoscopy plays a major role both in diagnosis and treatment of acute GIB, as allows the application of several hemostasis techniques during the diagnostic session, which should preferably be performed within 24 hours from the acute event. Read More

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December 2018

Approach to gastroenterological diseases in primary care.

Acta Biomed 2018 Dec 17;89(8-S):5-11. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Gastroenterological diseases are a source of morbidity, mortality and costs, and have a high frequency in general practice; for this reason, we have evaluated the current literature regarding the knowledge and management of these disorders by general practitioners, finding little knowledge and adherence to guidelines, highlighting the need for continuous updating in this regard, and greater collaboration between specialists and general practitioners. Read More

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December 2018

Is the risk of contrast-induced nephropathy a real contraindication to perform intravenous contrast enhanced Computed Tomography for non-traumatic acute abdomen in Emergency Surgery Department?

Acta Biomed 2018 Dec 17;89(9-S):158-172. Epub 2018 Dec 17.

Department of Emergency and Trauma Surgery of University Hospital of Parma, Parma, Italy.

Background: Contrast enhanced Computed Tomography (CCT) is the most used imaging test to investigate acute abdominal clinical conditions, because of its high sensitivity and specificity. It is mandatory to make a correct and prompt diagnosis when life threatening abdominal diseases as mesenteric ischemia are suspected. Contrast medium administration was linked to acute renal failure, therefore radiologist often prefer to perform CCT without contrast in patients needing to undergo the exam with increased serum creatinine. Read More

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December 2018

Hemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases.

Acta Biomed 2018 Dec 17;89(9-S):153-157. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background: Shiga-toxin Escherichia coli productor (STEC) provokes frequently an important intestinal damage that may be considered in differential diagnosis with the onset of Inflammatory Bowel Disease (IBD). The aim of this work is to review in the current literature about Hemolytic Uremic Syndrome (HUS) and IBD symptoms at the onset, comparing the clinical presentation and symptoms, as the timing of diagnosis and of the correct treatment of both these conditions is a fundamental prognostic factor. A focus is made about the association between typical or atypical HUS and IBD and a possible renal involvement in patient with IBD (IgA-nephropathy). Read More

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December 2018

Diagnosis and management of intraductal papillary mucinous neoplasms of the pancreas.

Acta Biomed 2018 Dec 17;89(9-S):147-152. Epub 2018 Dec 17.

Gastroenterology Unit, Molinette Hospital, Torino University, Torino.

Background And Aim Of The Work: Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are cystic lesions with malignant potential. Given their increasing incidence in the latest years, a precise characterization and management of these lesions have become more and more crucial: even though the majority of IPMN has a benign and indolent course, it is fundamental to early recognize and stratify patients in order to accurately plan a tailored follow-up and to individuate those that would benefit of surgical treatment. The aim of this paper is to highlight the most recent evidence on IPMN available in the current literature. Read More

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December 2018

Epidemiology and risk factors of pancreatic cancer.

Acta Biomed 2018 Dec 17;89(9-S):141-146. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

The most frequent pancreatic cancer is pancreatic adenocarcinoma. It has high and early locally and distant invasiveness; this is the reason why it often shows little sign or symptoms in early stage and poor prognosis after the diagnosis, frequently in advanced stage. Although it is possible to detect this tumor in early stage because of its neoplastic precursor (PanINs). Read More

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December 2018

Fluorescence guided surgery in liver tumors: applications and advantages.

Acta Biomed 2018 Dec 17;89(9-S):135-140. Epub 2018 Dec 17.

Acute Care and Trauma Surgery Department, Maggiore Hospital of Parma, University of Parma, Italy.

The use of fluorescence-guided surgery for benign and malignant hepatobiliary (HPB) neoplasms has significantly increased and improved imaging methods creating new interesting perspectives. A major challenge in HPB surgery is performing radical resection with maximal preservation of the liver parenchyma and obtaining a low rate of complications. Despite the developments, visual inspection, palpation, and intraoperative ultrasound remain the most utilized tools during surgery today. Read More

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December 2018

Conservative treatment of acute appendicitis.

Acta Biomed 2018 Dec 17;89(9-S):119-134. Epub 2018 Dec 17.

Emergency, General and Trauma Surgery dept., Bufalini hospital, Cesena, Italy.

Acute appendicitis has been considered by surgeons a progressive disease leading to perforation for more than 100 years. In the last decades the theories about this concept gained attention, especially in adults. However, appendectomy for acute appendicitis remains the most common urgent/emergent surgical procedure. Read More

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December 2018

Development and usefulness of the new endoscopic classification: DICA.

Acta Biomed 2018 Dec 17;89(9-S):113-118. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Colonic Diverticulosis is one of the most common anatomical findings during colonoscopy. This condition has 60% incidence in the population over 60 years old. About 20% of patients will develop Diverticular Disease, and 5% of them will evolve into Diverticulitis. Read More

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December 2018

Epidemiology and risk factors for diverticular disease.

Acta Biomed 2018 Dec 17;89(9-S):107-112. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Diverticulosis of the colon is the most frequent anatomical alteration diagnosed at colonoscopy. The prevalence of the disease is higher in elderly patients over 65 years old, recent studies show an increment also in youngers over 40 years old. Even its large prevalence in the population, its pathophysiology still remain poorly understood. Read More

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December 2018

Potential predictive biomarkers in locally advanced rectal cancer treated with preoperative chemo-radiotherapy.

Acta Biomed 2018 Dec 17;89(9-S):102-106. Epub 2018 Dec 17.

Department of Medicine and Surgery, Unit of Pathological Anatomy, University Hospital of Parma, Parma, Italy.

Fluorouracil-based preoperative chemoradiotherapy represents a standard option for the treatment of locally advanced rectal cancer. Randomized clinical trials have shown that fluorouracil concomitant to preoperative radiation enhances tumor shrinkage (with 10% to 15% of the patients showing a complete pathological tumor response) compared with preoperative radiation alone. A high response rate is of clinical importance in rectal cancer, since patients who achieve a complete pathological response may experience improved long-term survival. Read More

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December 2018

Microsatellite instability in colorectal cancer.

Acta Biomed 2018 Dec 17;89(9-S):97-101. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Microsatellites are short tandem repeat DNA sequences of one to tetra base pairs distributed throughout the human genome, both in coding and non-coding regions. Owing to their repeated structure, microsatellites are particularly prone to replication errors that are normally repaired by the Mismatch Repair (MMR) system. MMR is a very highly conserved cellular process, involving many proteins, resulting in the identification, and subsequent repair of mismatched bases, likely to have arisen during DNA replication, genetic recombination or chemical or physical damage. Read More

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December 2018

Nutrition and lipidomic profile in colorectal cancers.

Acta Biomed 2018 Dec 17;89(9-S):87-96. Epub 2018 Dec 17.

National Institute of Gastroenterology "S. De Bellis" Research Hospital, Castellana Grotte, Italy.

Background: Adherence to a healthy diet has been reported to be essential for the primary prevention of colorectal cancer, through a reduction of tissue inflammation, a low concentration of circulating lipoproteins and lower levels of serum cholesterol. Since an altered expression of the fatty acids pattern has been demonstrated to be a crucial event in colorectal carcinogenesis, lipidomic analysis is considered able to identify early diagnostic and prognostic biomarkers of complex diseases such as colorectal cancer.

Methods: cell membrane fatty acid profile and serum lipoproteins pattern were evaluated by gas chromatography and electrophoresis method respectively. Read More

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December 2018

Inverse association between Helicobacter pylori and inflammatory bowel disease: myth or fact?

Acta Biomed 2018 Dec 17;89(9-S):81-86. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background: Inflammatory bowel diseases (IBD), are chronic, relapsing-remitting diseases of the gastrointestinal tract, including Crohn's disease (CD), Ulcerative colitis (UC) and Unclassified IBD (IBDU). Their pathogenesis involves genes and environment as cofactors in inducing autoimmunity; particularly the interactions between enteric pathogens and immunity is being studied. Helicobacter pylori (HP) is common pathogen causing gastric inflammation. Read More

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December 2018

Renal lithiasis and inflammatory bowel diseases, an update on pediatric population.

Acta Biomed 2018 Dec 17;89(9-S):76-80. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background And Aim Of The Work: Historical studies have demonstrated that the prevalence of symptomatic nephrolithiasis is higher in patients with inflammatory bowel disease (IBD), compared to general population. The aim of the review was to analyze literature data in order to identify the main risk conditions described in literature and the proposed treatment.

Methods: A research on the databases PubMed, Medline, Embase and Google Scholar was performed by using the keywords "renal calculi/lithiasis/stones" and "inflammatory bowel diseases". Read More

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December 2018

The role of diet in the prevention and treatment of Inflammatory Bowel Diseases.

Acta Biomed 2018 Dec 17;89(9-S):60-75. Epub 2018 Dec 17.

National Institute of Gastroenterology "S. De Bellis" Research Hospital, Castellana Grotte, Italy.

Inflammatory bowel diseases (IBD) - Crohn's disease (CD) and ulcerative colitis (UC) - are chronic conditions characterised by relapsing inflammation of the gastrointestinal tract. They represent an increasing public health concern and an aetiological enigma due to unknown causal factors. The current knowledge on the pathogenesis of IBD is that genetically susceptible individuals develop intolerance to a dysregulated gut microflora (dysbiosis) and chronic inflammation develops as a result of environmental triggers. Read More

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December 2018

The impact of intestinal microbiota on bio-medical research: definitions, techniques and physiology of a "new frontier".

Acta Biomed 2018 Dec 17;89(9-S):52-59. Epub 2018 Dec 17.

Dipartimento Medico-Geriatrico-Riabilitativo, Azienda Ospedaliero-Universitaria di Parma.

In recent years the metagenomics techniques have allowed to study composition and function of the intestinal microbiota. The microbiota is a new frontier of biomedical research to be explored and there is growing evidence of its fundamental health-promoting activity. The present review gives a synthetic overview on the characteristics and the role of the microbiota in the adult with particular reference to physiology, pathophysiology and relationships with the host and the environment. Read More

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December 2018

Digestive disorders and Intestinal microbiota.

Acta Biomed 2018 Dec 17;89(9-S):47-51. Epub 2018 Dec 17.

Dipartimento Medico-Geriatrico-Riabilitativo, Azienda Ospedaliero-Universitaria di Parma.

In the last decade, a barge body of scientific literature has suggested that specific alterations of the gut microbiota may be associated with ther development and clinical course of several gastrointestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, celiac disease, gastrointestinal cancer and Clostridium difficile infection. These alterations are often referred to as "dysbiosis", a generic term designing reduction of gut microbiota biodiversity and alterations in its composition. Here, we provide a synthetic overview of the key concepts on the relationship between intestinal microbiota and gastrointestinal diseases, focusing on the translation of these concepts into clinical practice. Read More

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December 2018

Applications of wireless capsule endoscopy in pediatric age: an update.

Acta Biomed 2018 Dec 17;89(9-S):40-46. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background: The small bowel has often been considered the mysterious "black hole" of the gastrointestinal tract. With regards to this, the development of the wireless capsule endoscopy (WCE) has represented a turning point. It is a non-invasive technique, enabling an excellent visualization of the small bowel (SB) mucosa without the use of radiation. Read More

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December 2018

Endoscopic ultrasound in pediatric population: a comprehensive review of the literature.

Acta Biomed 2018 Dec 17;89(9-S):33-39. Epub 2018 Dec 17.

Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background And Aim: Endoscopic ultrasonography (EUS) with or without fine needle aspiration/biopsy (FNA/B) is a well-established diagnostic tool in adults for the evaluation and management of gastrointestinal (GI) tract disorders. Its use in children is still limited as well as literature in pediatric age is limited, although the application of EUS is now increasing. The present article aims to review the current literature about EUS indication, accuracy and safety in pediatric age. Read More

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December 2018
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