4,454 results match your criteria Acta clinica Belgica[Journal]


Non-primary CMV infection not always innocent. A case-report and literature review.

Acta Clin Belg 2020 Jun 3:1-5. Epub 2020 Jun 3.

Department of Neonatology, Antwerp University Hospital, University of Antwerp , Belgium.

Objectives: Cytomegalovirus (CMV) is the most common infectious cause of congenital malformations. CMV infections are frequently symptomatic in case of a primary infection during pregnancy. Generally, maternal immunity protects the newborn against a symptomatic course of the CMV infection. Read More

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http://dx.doi.org/10.1080/17843286.2020.1773651DOI Listing

Diagnosis and treatment of gonorrhoea: 2019 Belgian National guideline for primary care.

Acta Clin Belg 2020 Jun 2:1-9. Epub 2020 Jun 2.

Department of Clinical Sciences, Institute of Tropical Medicine , Antwerp, Belgium.

Objectives: Gonorrhoea continues to be a public health concern in Belgium with pharyngeal and rectal infections increasing in persons with high-risk sexual behaviour. Belgian health care practitioners rely on international guidance when managing gonorrhoea resulting in non-adapted suboptimal care for the Belgian patient. This guideline will rectify this situation. Read More

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http://dx.doi.org/10.1080/17843286.2020.1773111DOI Listing

Outpatient parenteral antibiotic therapy for the treatment of prosthetic knee and hip infections in Belgium, a cost minimization analysis.

Acta Clin Belg 2020 Jun 2:1-8. Epub 2020 Jun 2.

Department of Orthopaedics, University Hospital Brussels , Brussels, Belgium.

Objectives: Prosthetic joint infections (PJI) are treated with prolonged periods of intravenous (IV) antibiotics combined with one or more appropriate surgical procedures. In Belgium, patients receive their IV treatments as inpatients, whereas in other parts of the world similar IV antibiotics can be given as outpatient parenteral antibiotic therapy (OPAT), without jeopardising patient outcomes. The purpose of this paper was to analyse the financial feasibility of OPAT for PJI in Belgium. Read More

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http://dx.doi.org/10.1080/17843286.2020.1772572DOI Listing

Drug reaction with eosinophilia and systemic symptoms (DRESS) induced by phenytoin re-exposure: case report and systematic review.

Acta Clin Belg 2020 May 29:1-9. Epub 2020 May 29.

Servicio de Neurología, Departamento de Medicina y Oficina de Apoyo a la Docencia e Investigación (OADI), Hospital Daniel Alcides Carrión , Callao, Perú.

Introduction: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an adverse and severe skin reaction due to patients' susceptibility to medications, including phenytoin. The objective was to explore the characteristics of patients with DRESS secondary to phenytoin through a systematic review.

Methods: We describe a case of DRESS syndrome secondary to phenytoin in a patient with previous exposure to this drug. Read More

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http://dx.doi.org/10.1080/17843286.2020.1767459DOI Listing

Impact of PrEP on a STI clinic in a Belgian context: a provider's perspective.

Acta Clin Belg 2020 May 29:1-5. Epub 2020 May 29.

Department of Clinical Sciences, Institute of Tropical Medicine , Antwerp, Belgium.

Objectives: To assess the impact of Pre-Exposure Prophylaxis (PrEP) to avoid HIV infection as an additional service in a routine Sexually Transmitted Infections (STI) clinic.: We used routinely obtained retrospective data to estimate the increased workload on the existing facilities. We focussed on STI registration through the laboratory registration system and put this in a national perspective. Read More

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http://dx.doi.org/10.1080/17843286.2020.1767995DOI Listing

Benefits of antiretroviral therapy initiation during acute HIV infection.

Acta Clin Belg 2020 May 29:1-9. Epub 2020 May 29.

HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University , Ghent, Belgium.

Objectives: In the last decade, there has been increasing scientific and legislative focus on antiretroviral treatment (ART) for all people living with HIV. Especially early ART initiation, preferably during acute HIV infection, has been named as a promising strategy, both for the individual and for the society. This article will review the benefits and possible future applications of immediate ART initiation during acute HIV infection and explore the remaining hurdles towards this strategy. Read More

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http://dx.doi.org/10.1080/17843286.2020.1770413DOI Listing

Acquired hemophilia A revealed by spontaneous bleeding in an 80-year-old man: a marginal diagnosis?

Acta Clin Belg 2020 May 27:1-3. Epub 2020 May 27.

Department of Hematology, Hôpital Erasme, Université Libre De Bruxelles , Brussels, Belgium.

This case report illustrates the difficulty associated with diagnosing acquired hemophilia A by reviewing the case of an 80-year-old man admitted to the hospital for anemia. A prolonged activated partial thromboplastin time (aPTT) was not noticed until the patient developed a severe hemorrhagic syndrome. Read More

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http://dx.doi.org/10.1080/17843286.2020.1768735DOI Listing

Parathormone, bone alkaline phosphatase and 25-hydroxyvitamin D status in a large cohort of 1200 children and teenagers.

Acta Clin Belg 2020 May 22:1-6. Epub 2020 May 22.

Clinical Chemistry Department, CHU De Liège , Liège, Belgium.

Objectives: 25-Hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone alkaline phosphatase (BALP) are biomarkers of calcium/phosphate metabolism and bone turnover. Although vitamin D deficiency is a well-known cause of secondary hyperparathyroidism, few studies have considered vitamin D status when establishing reference ranges. In this study, we report PTH levels according to the vitamin D status and BALP levels in a large cohort of 1200 children. Read More

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http://dx.doi.org/10.1080/17843286.2020.1769285DOI Listing

Hepatitis C in two general practices in Flanders, Belgium: is there a need to reconsider current screening recommendations?

Acta Clin Belg 2020 May 21:1-8. Epub 2020 May 21.

Department of Family Medicine, Ghent University , Ghent, Belgium.

Objectives: Hepatitis C virus (HCV) is a major cause of acute and chronic liver disease (e.g. cirrhosis and hepatocellular carcinoma). Read More

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http://dx.doi.org/10.1080/17843286.2020.1763670DOI Listing

Association of PC and AT levels in the early phase of STEMI treated with pPCI with LV systolic function and 6-month MACE.

Acta Clin Belg 2020 May 21:1-7. Epub 2020 May 21.

Department for Science, Teaching and Clinical Trials, University Clinical Centre Tuzla , Tuzla, Bosnia and Herzegovina.

Objectives: To examine a relationship between protein C (PC) and antithrombin III (AT III) activities with ejection fraction of left ventricle (EFLV), in the early phase of acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), and to investigate whether PC and AT III are associated with major adverse cardiovascular events (MACE) within 6 months following from pPCI.

Patients And Methods: The research had a prospective character and included 357 patients who had, following the diagnosis of the STEMI, undergone pPCI at the Clinic of Cardiology and Emergency Internal Medicine, Military Medical Academy, Belgrade, Serbia, from January 2010 until April 2019.

Results: The EFLV positively correlated with PC values (rho = 0. Read More

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http://dx.doi.org/10.1080/17843286.2020.1766850DOI Listing

Interval between corticosteroids administration and birth.

Authors:
G H Page

Acta Clin Belg 2020 May 19. Epub 2020 May 19.

Jan Yperman Hospital, Ypres, Belgium,

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http://dx.doi.org/10.1080/17843286.2020.1768347DOI Listing

In reply to 'clinical biochemistry test eliminator providing cost-effectiveness with five algorithms': the Casablanca strategy.

Acta Clin Belg 2020 May 18:1-2. Epub 2020 May 18.

Department of General Internal Medicine, University Hospitals Leuven, Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Infectious and Inflammatory Disease, Leuven, Belgium,

In this journal, Ataman Gönel recently demonstrated that elimination of requested unnecessary tests by means of algorithms in an artificial intelligence program may contribute to the cost-effectiveness of medicine. However, test ordering is an essential part of clinical medicine and decision-making. Interns are responsible for a modest but significant excess in laboratory utilization and underestimate their control over laboratory testing. Read More

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http://dx.doi.org/10.1080/17843286.2020.1763672DOI Listing

Biosimilars in Belgium: a proposal for a more competitive market.

Acta Clin Belg 2020 May 13:1-12. Epub 2020 May 13.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

More than ten years after the first biosimilars were authorized for use in the European Union, Belgium still experiences limited competition from biosimilars, as exemplified by low market shares. Achieving high biosimilar market shares is not necessarily a goal in itself, as cost savings are also realized by mandatory price reductions on originator medicines in Belgium. However, we believe that biosimilars play a role in ensuring the long-term sustainability of the off-patent biologicals market. Read More

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http://dx.doi.org/10.1080/17843286.2020.1761690DOI Listing

Patient empowerment in Flemish hospital wards: a cross-sectional study.

Acta Clin Belg 2020 May 13:1-9. Epub 2020 May 13.

Faculty of Medicine and Health Sciences, Department of Public Health and Primary Care, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium.

: Measuring empowerment of patients on Flemish hospital wards by the short form of the Patient Activation Measure (PAM-13) and exploring the association between patient empowerment and patient-centred care, health literacy, patient- and context-related characteristics.: Secondary analysis of data collected in nine regional hospitals and one university hospital in Flanders between February and June 2016. Patients needed to be admitted for a least 1 day, aged 18 years or over, and mentally competent with adequate ability to speak and read the Dutch language. Read More

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http://dx.doi.org/10.1080/17843286.2020.1762350DOI Listing

A rare presentation of kidney failure in a patient with giant cell arteritis: case report and review of literature.

Acta Clin Belg 2020 May 12:1-4. Epub 2020 May 12.

Department of Nephrology, Ghent University Hospital, Ghent, Belgium.

Although giant cell arteritis, also called temporal arteritis, is the most common primary vasculitis in the elderly, an association with AA amyloidosis has rarely been reported. AA amyloidosis is a disorder that results from the extracellular deposition of proteolytic cleavage products of serum amyloid A, which occurs in the setting of long-standing inflammation. We present a case of a patient with giant cell arteritis who developed a rapidly deteriorating kidney function, due to AA amyloidosis. Read More

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http://dx.doi.org/10.1080/17843286.2020.1763671DOI Listing

Intrapancreatic accessory spleen mimicking pancreatic NET: can unnecessary surgery be avoided?

Acta Clin Belg 2020 May 12:1-4. Epub 2020 May 12.

Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium.

Pancreatic nodules are frequently found incidentally and often pose a diagnostic and therapeutic challenge when surgery is considered. We present the case of a 66-year-old cirrhotic patient with a pancreatic nodule with signal intensity and contrast enhancement pattern suggestive for a non-functional neuroendocrine lesion. A Gallium-DOTATOC PET-CT scan revealed a correspondent focal tracer uptake in the pancreatic tail. Read More

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http://dx.doi.org/10.1080/17843286.2020.1762351DOI Listing

Use of chimerism analysis after allogeneic stem cell transplantation: Belgian guidelines and review of the current literature.

Acta Clin Belg 2020 May 2:1-9. Epub 2020 May 2.

Department of Hematology, University Hospital, Ghent University, Ghent, Belgium.

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option in both adult and pediatric patients with malignant and non-malignant hematological diseases.  Chimerism analysis, which determines the donor or recipient origin of hematopoietic cells in HSCT recipients, is an essential aspect of post-HSCT follow-up. To review the current literature and develop Belgian consensus guidelines for the use of chimerism analysis in the standard of care after allogeneic HSCT. Read More

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http://dx.doi.org/10.1080/17843286.2020.1754635DOI Listing

Antenatal corticosteroids-to-birth interval in preterm birth.

Acta Clin Belg 2020 Apr 30:1-8. Epub 2020 Apr 30.

Neonatal Intensive Care Unit, Ghent University Hospital, Ghent, Belgium.

: The purpose of this study was to compare short-term outcomes in children born between 24 and 34 weeks' gestation, according to observed antenatal corticosteroids (ACS)-to-birth intervals. Research question: 'Is there a difference in short-term outcomes between observed ACS-to-birth intervals across a range of gestational ages at birth?': Cohort study assessing differences in incidence of short-term neonatal outcomes according to the observed interval between the last administration of ACS and birth. Linear, non-weighted GEE models with an independence working correlation structure were fitted to infant level data providing valid point estimates for either incidence or rate differences (binary outcomes) or average differences (continuous outcomes). Read More

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http://dx.doi.org/10.1080/17843286.2020.1758471DOI Listing

COVID-19 pandemic: overview of protective-ventilation strategy in ARDS patients.

Acta Clin Belg 2020 Apr 27:1-3. Epub 2020 Apr 27.

Department of Intensive Care Medicine, CHU UCL Namur, Dinant, Belgium.

: In the context of COVID-19 pandemic, the aim of this manuscript is to provide a standard of care of patients with ARDS for non-emergency medicine trained physicians who are not customary with mechanical ventilation.: We conducted a systematic review of the literature to investigate the best practice recommendations regarding the mechanical ventilation of patients with ARDS.: We summarized the principal strategies for lung-protective ventilation of patients with ARDS. Read More

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http://dx.doi.org/10.1080/17843286.2020.1761162DOI Listing

Phone CPR and barriers affecting life-saving seconds.

Acta Clin Belg 2020 Apr 19:1-6. Epub 2020 Apr 19.

Department of Emergency Medicine, University Hospital of Leuven, Leuven, Belgium.

: Phone cardiopulmonary resuscitation (CPR) increases the rate of bystander CPR to patients suffering from an out-of-hospital cardiac arrest (OHCA). This study analyzed the effectiveness of the ALERT protocol for instructing laypeople in bystander CPR.: All 244 phone CPR calls to the emergency medical communication center in Leuven during a one-year period were analyzed. Read More

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http://dx.doi.org/10.1080/17843286.2020.1752454DOI Listing

The implementation of a structured specialized consultation for psoriasis management.

Acta Clin Belg 2020 Apr 17:1-6. Epub 2020 Apr 17.

Department of Head & Skin, Ghent University, Ghent, Belgium.

: Psoriasis is a chronic skin disease requiring a multidimensional approach, given its varying appearance, presence of comorbidities and complex treatment regimens. Psoriasis care is however often performed fragmented and, in case of flares, reactive with little integrated information on and for the patient. Literature suggests a multileveled approach of psoriasis, but the effects of its implementation have not yet been validated. Read More

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http://dx.doi.org/10.1080/17843286.2020.1750747DOI Listing

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells.

Acta Clin Belg 2020 Apr 14:1-5. Epub 2020 Apr 14.

Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.

Cytomegalovirus (CMV) infection is one of the most common complications in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. The classic antiviral treatments have shown clinical efficacy but are often associated with drug resistance. Reconstitution of CMV-specific cellular immunity is essential in controlling CMV infection; therefore, adoptive transfer of CMV-specific T cells is a promising treatment option. Read More

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http://dx.doi.org/10.1080/17843286.2020.1752446DOI Listing

Verrucous hyperplasia and verrucous carcinoma in head and neck: use and benefit of methotrexate.

Acta Clin Belg 2020 Apr 11:1-5. Epub 2020 Apr 11.

Department of Medical Oncology, Department of Drug Research Unit Ghent, Cancer Research Institute Ghent, Ghent University and Ghent University Hospital, Ghent, Belgium.

: Verrucous hyperplasia (VH) and verrucous carcinoma (VC) of the head and neck are two (pre)malignant entities that are slowly progressive with low tendency to metastasize. However, they can reduce the patient's Quality of Life (QoL) and may even transform into squamous cell carcinoma (SCC). As they are typically approached by surgical resection, some patients do not qualify for surgery. Read More

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http://dx.doi.org/10.1080/17843286.2020.1752455DOI Listing

Prognostic determinants in patients with non traumatic intracerebral hemorrhage: a real life report.

Acta Clin Belg 2020 Apr 12:1-8. Epub 2020 Apr 12.

Emergency Department, San Giuseppe Hospital, Empoli, Italy.

: Nontraumatic intracerebral hemorrhage (ICH) remains a devastating disease for high in-hospital and long-term mortality and residual neurological disability. The aim of our study was to analyze the prognostic factors in patients managed for ICH in the real-life clinical practice.: We retrospectively analyzed clinical and neuro-radiological data of consecutive patients admitted to our Hospital for ICH along 1 year. Read More

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http://dx.doi.org/10.1080/17843286.2020.1750151DOI Listing

Tigecycline-induced life-threatening coagulopathy in a patient with a Mycobacterium abscess: a case report and step-by-step diagnostic approach.

Acta Clin Belg 2020 Apr 7:1-5. Epub 2020 Apr 7.

Tigecycline is a broad-spectrum antibiotic that is indicated in the treatment of complicated intra-abdominal infections and complicated skin and skin and soft-tissue infections. We report the case of a 53-year old kidney transplant patient with a severe Mycobacterium abscess who developed life-threatening coagulopathy after initiation of tigecycline therapy. Further analysis revealed a severe hypofibrinogenemia. Read More

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http://dx.doi.org/10.1080/17843286.2020.1747197DOI Listing

Wolff Parkinson White and recreational (meth)amphetamine use: a potentially lethal combination.

Acta Clin Belg 2020 Apr 3:1-4. Epub 2020 Apr 3.

Department of Cardiology, Ghent University Hospital, Ghent, Belgium.

Cardiac arrest in Wolff-Parkinson-White (WPW) is a rare event, and although some patients appear to be at greater risk, there is no consensus on clear risk factors. We present a case of a 23-year-old male patient, with a known history of WPW pattern, who suffered an out of hospital ventricular fibrillation after the consumption of rather small dose of (meth)amphetamines. The use of illegal drug can predispose WPW patients to fatal arrhythmia and cardiac arrest. Read More

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http://dx.doi.org/10.1080/17843286.2020.1746885DOI Listing

Diagnosis and immunosuppressive treatment of inflammatory cardiomyopathy: a case report.

Acta Clin Belg 2020 Apr 1:1-5. Epub 2020 Apr 1.

Department of Cardiology, OLV Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium.

: Definite diagnosis of myocarditis requires an endomyocardial biopsy (EMB) showing an inflammatory infiltrate. However, there are important limitations on establishing the diagnosis solely upon histological criteria. The main objective of this case report is to highlight the difficulty of diagnosis, but also to evaluate treatment in virus-negative inflammatory cardiomyopathy. Read More

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http://dx.doi.org/10.1080/17843286.2020.1747714DOI Listing

Acquired C1-inhibitor deficiency due to splenic marginal zone lymhoma: Case Report.

Acta Clin Belg 2020 Mar 31:1-4. Epub 2020 Mar 31.

Nuclear Medicine and Molecular Imaging, University Hospitals Leuven, Leuven, Belgium.

We present the case of a 67-year-old woman who suffered recurrent episodes of angioedema of the face and larynx. After thorough biochemical investigations, an acquired deficiency of C1-INH was suspected. To evaluate a potential underlying malignancy, a whole-body FDG-PET/CT was performed and showed solely a marked splenomegaly pointing towards a splenic marginal zone lymphoma, which was confirmed by pathological examination. Read More

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http://dx.doi.org/10.1080/17843286.2020.1746552DOI Listing

Epithelioid angiosarcoma arising after an endovascular aneurysm repair: case report and review of the literature.

Acta Clin Belg 2020 Mar 18:1-5. Epub 2020 Mar 18.

Department of Anatomo-pathology, Institut De Pathologie Génétique (IPG), Gosselies, Belgium.

We report the case of a 68-year-old male who was hospitalized for suspicion of endoleak and thrombosis of an aortic endoprosthesis, arising after multiple endovascular interventions during the last few months. During the intervention, amass was discovered, and biopsies were made. The anatomopathology results were in favor of an epithelioid angiosarcoma with atypical expression of CD31 and ERG- and no amplification of c-MYC. Read More

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http://dx.doi.org/10.1080/17843286.2020.1742489DOI Listing

Nivolumab and anti-HCV activity, a case report.

Acta Clin Belg 2020 Mar 17:1-5. Epub 2020 Mar 17.

Department of Gastroenterology and Hepatology, Antwerp University Hospital (UZA), Antwerp, Belgium.

Exhaustion of antigen-specific T-cells in order to escape immune destruction is frequently seen in chronic viral infection and different types of cancer. Blockade of overexpressed negative co-stimulatory pathways, a process known as immune checkpoint modulation, is a promising novel therapy that could improve the treatment of liver diseases with features of T cell exhaustion. We present a case of a 54-year-old hepatitis C virus (HCV) positive patient with an acute flare of hepatitis during nivolumab treatment for a stage IV lung carcinoma, an anti-programmed death-1 (PD-1) immunotherapy. Read More

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http://dx.doi.org/10.1080/17843286.2020.1741897DOI Listing

Implementation of a protocol using ketamine-propofol ('ketofol') in a 1 to 4 ratio for procedural sedation in adults at a university hospital emergency department - report on safety and effectiveness.

Acta Clin Belg 2020 Mar 14:1-6. Epub 2020 Mar 14.

Department of Emergency Medicine, Ghent University Hospital, Ghent, Belgium.

: To test the feasibility of an evidence-based protocol for procedural sedation in adults at our emergency department, using a mixture of ketamine and propofol ('ketofol') in a 1 to 4 ratio. We hypothesize that the protocol is safe and effective and can facilitate procedural sedation.: During 14 months, adults in need of procedural sedation at our university hospital emergency department were included in a prospective convenience sample study. Read More

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http://dx.doi.org/10.1080/17843286.2020.1741228DOI Listing

Symmetric polyneuropathy after viral symptomatology - not always Guillain-Barré Syndrome.

Acta Clin Belg 2020 Mar 13:1-8. Epub 2020 Mar 13.

Department of Nephrology, AZ St. Elisabeth Hospital, Zottegem, Belgium.

: Guillain-Barré Syndrome usually presents with ascending symmetric polyneuropathy, typically preceded by a viral infection. Despite the low incidence, physicians will often include Guillain-Barré Syndrome in their differential diagnosis. However, another underlying cause of polyneuropathy known as ANCA-associated vasculitis (AAV) is even more rare than Guillain-Barré Syndrome and therefore is usually overlooked. Read More

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http://dx.doi.org/10.1080/17843286.2020.1740858DOI Listing

A unilateral inguinofemoral granulomatous lymphadenitis in a two-year-old girl. A case report.

Acta Clin Belg 2020 Mar 10:1-3. Epub 2020 Mar 10.

Department of Pediatrics, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.

is an environmental contaminant and is considered as an emerging human pathogen. We report the case of a granulomatous lymphadenitis in a two-year-old girl. A two-year-old, previously healthy, Caucasian girl developed a unilateral inguinofemoral granulomatous lymphadenitis with . Read More

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http://dx.doi.org/10.1080/17843286.2020.1740464DOI Listing

The incidence of lower respiratory tract infections and pneumococcal vaccination status in adults in flemish primary care.

Acta Clin Belg 2020 Mar 9:1-11. Epub 2020 Mar 9.

Academic Center for General Practice, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

Pneumococcal vaccination coverage of adults at risk for pneumococcal disease is below recommended levels. There is no observational data on pneumococcal vaccination and the incidence of lower respiratory tract infections in a general adult population. The current study had the objective to explore the incidence of lower respiratory tract infections and the pneumococcal vaccine coverage in function of age, influenza vaccination status and risk status, in Flanders, Belgium. Read More

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http://dx.doi.org/10.1080/17843286.2020.1735113DOI Listing

Malnutrition risk and its association with adverse outcomes in a Belgian cohort of community-dwelling adults aged 80 years and over.

Acta Clin Belg 2020 Mar 5:1-8. Epub 2020 Mar 5.

Department of Public Health and Primary Care, Katholieke Universiteit Leuven (Kuleuven), Leuven, Belgium.

: To investigate the prevalence of malnutrition risk and its association with adverse outcomes in a Belgian cohort of community-dwelling adults aged ≥80 years, a worldwide growing age-group.: In the BELFRAIL cohort, malnutrition risk was evaluated with the Mini Nutritional Assessment (MNA total score <24) and prealbumin levels (<20 mg/dl). Agreement between them was assessed with Kohen's kappa coefficient. Read More

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http://dx.doi.org/10.1080/17843286.2020.1737779DOI Listing

Lung cancer in a CF patient: combination of bad luck or is there more to say?

Acta Clin Belg 2020 Mar 5:1-2. Epub 2020 Mar 5.

Respiratory Division, University Hospital UZ Brussel, Brussels, Belgium.

Patients with cystic fibrosis have increased risk for gastrointestinal cancer, lymphoid leukemia and testicular carcinomas. Chronic inflammation does not seem to be the only contributing factor. Mutations and epigenetic alterations in the CFTR gene may alter susceptibility to develop cancer. Read More

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http://dx.doi.org/10.1080/17843286.2020.1737780DOI Listing

Lemierre's syndrome in adulthood, a case report and systematic review.

Acta Clin Belg 2020 Feb 29:1-11. Epub 2020 Feb 29.

Department of Internal Medicine and Infectious Disease, Vrije Universiteit Brussel, UZ Brussel, Belgium.

: Lemierre's syndrome is a septic thromboembolic complication of an oropharyngeal or neck infection, primarily caused by Fusobacterium species. Although it usually affects young healthy patients, some case reports describe this syndrome in older population.: A case report and a systematic review of the literature were conducted to investigate the late onset of Lemierre's syndrome. Read More

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http://dx.doi.org/10.1080/17843286.2020.1731661DOI Listing
February 2020

Variable reactivity of Rh D antigen and its serological characterization.

Acta Clin Belg 2020 Feb 28:1-5. Epub 2020 Feb 28.

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, India.

: Variation in the reactivity on Rh D typing may pose challenges in interpretation and ambiguity in further patient management.: A prospective study was conducted in the department of transfusion medicine for a period of 18 months. Blood grouping was performed by fully automated equipment employing column agglutination technique. Read More

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http://dx.doi.org/10.1080/17843286.2020.1735115DOI Listing
February 2020

Evaluation and monitoring of response to platelet transfusion therapy: experience from a tertiary care center.

Acta Clin Belg 2020 Feb 22:1-4. Epub 2020 Feb 22.

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.

: Refractoriness to platelet transfusion is defined as Corrected Count Increment (CCI) <5000 after two sequential ABO identical transfusions. Immune causes include alloimmunization to HLA and/or platelet-specific antigens. Analysis of various factors leading to platelet refractoriness would help in the management of the patient in a timely manner. Read More

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http://dx.doi.org/10.1080/17843286.2020.1732568DOI Listing
February 2020

Hepatitis E virus-associated haemophagocytic lymphohistiocytosis.

Acta Clin Belg 2020 Feb 24:1-4. Epub 2020 Feb 24.

Department of Laboratory Medicine, Medical Microbiology, AZ Sint-Jan Hospital, Bruges, Belgium.

We report the first documented case of hepatitis E virus-associated haemophagocytic lymphohistiocytosis. This case emphasizes the fact that infectious agents other than those classically described should be taken into consideration as a potential trigger of virus-associated haemophagocytic syndrome. Prompt recognition is crucial to start early treatment of the underlying infection and possibly improve the outcome of this frequently fatal syndrome. Read More

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http://dx.doi.org/10.1080/17843286.2020.1733179DOI Listing
February 2020

An ectopic Cushing's syndrome as a cause of severe refractory hypokalemia in the ICU.

Acta Clin Belg 2020 Feb 23:1-6. Epub 2020 Feb 23.

Department of Intensive Care, Brugmann University Hospital, Brussels, Belgium.

: Ectopic Cushing's syndrome is a very rare condition caused by an ACTH-secreting tumor outside the pituitary or adrenal glands, and the majority of these cases are encountered in the context of paraneoplastic syndromes. The ectopic source of ACTH secretion is not always obvious to detection and can be challenging. We report a rare case, in which a hidden ACTH-secreting carcinoid tumor of the lung caused a severe refractory hypokalemia, leading us to a race against time to locate the tumor. Read More

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http://dx.doi.org/10.1080/17843286.2020.1734162DOI Listing
February 2020

Announcement of an updated Belgian consensus on the assessment and management of obesity.

Acta Clin Belg 2020 Feb 19:1-3. Epub 2020 Feb 19.

Departement of Diabetology and Nutrition, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1080/17843286.2020.1727665DOI Listing
February 2020

Antibiotic use and resistance in Belgium: the impact of two decades of multi-faceted campaigning.

Acta Clin Belg 2020 Feb 5:1-9. Epub 2020 Feb 5.

Laboratory of Medical Microbiology, Vaccine & Infectious Diseases Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.

: To present an overview of almost two decades of multi-faceted campaigning by the Belgian Antibiotic Policy Coordination Committee (BAPCOC) and partners, and its impact on public and prescribers' awareness, outpatient antibiotic use, its cost and antimicrobial resistance in Belgium.: Awareness of both public and prescribers was assessed through pre- and post-campaign interviews and surveys. Outpatient antibiotic use was evaluated using national reimbursement data expressed in number of defined daily doses and packages (a good proxy for treatments) per 1000 inhabitants per day (DID and PID, respectively) from July 1997 to June 2018. Read More

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http://dx.doi.org/10.1080/17843286.2020.1721135DOI Listing
February 2020

Bacteremia and complicated parapneumonic effusion caused by in an elderly patient.

Acta Clin Belg 2020 Feb 3:1-3. Epub 2020 Feb 3.

Laboratory of Clinical Microbiology, Aalst, Belgium.

We describe a case of bacteremia and a complicated parapneumonic effusion caused by , in an elderly patient with underlying chronic hepatitis C infection. Read More

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http://dx.doi.org/10.1080/17843286.2020.1724448DOI Listing
February 2020

Similarities between pediatric FMF patients with sacroiliitis and pediatric juvenile spondyloarthropathy patients with sacroiliitis: a preliminary study.

Acta Clin Belg 2020 Feb 3:1-6. Epub 2020 Feb 3.

Department of Pediatric Rheumatology, Dr Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent, self-limited attacks of fever with serositis. Acute recurrent arthritis is the most common form of musculoskeletal involvement in FMF; however, ≤5% of FMF patients can develop chronic arthritis, including sacroiliitis. It is difficult to determine if sacroiliitis is a musculoskeletal finding of FMF or if they are concomitant diseases-FMF and juvenile spondyloarthropathy (JSpA). Read More

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http://dx.doi.org/10.1080/17843286.2020.1724450DOI Listing
February 2020

Sarcoidosis presenting as cardiac tamponade: a case report.

Acta Clin Belg 2020 Jan 30:1-5. Epub 2020 Jan 30.

Department of Cardiology, University Hospital of Leuven, Leuven, Belgium.

A 62-year-old man without medical history presented with a cardiac tamponade due to a voluminous sterile hemorrhagic exudate. Hypermetabolic mediastinal lymph nodes were found on a PET-CT and pathological analysis revealed non-necrotizing granulomatous adenitis, a finding compatible with sarcoidosis. Steroids were started with rapid clinical improvement and complete resolution of the pericardial effusion. Read More

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http://dx.doi.org/10.1080/17843286.2020.1724429DOI Listing
January 2020

The impact of childhood 13-valent pneumococcal conjugate vaccination on overall invasive pneumococcal disease, including the oldest old.

Acta Clin Belg 2020 Jan 30:1-8. Epub 2020 Jan 30.

Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Our aim was to compare serotype distribution in invasive pneumococcal disease (IPD) in the Belgian population before and after introduction of the 13-valent conjugte vaccine (PCV13) in the national childhood vaccination schedule. Serotyping was performed on 12,534 pleural fluid and bacteraemic Streptococcus pneumoniae isolates sent to the National Reference Centre. We compared the distribution of serotypes (ST)/serogroups (SG) between the periods before (2007-2010) and after (2012-2015) the introduction of PCV13, in children and adults of different age groups, including older individuals (65-84 and ≥85 years). Read More

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http://dx.doi.org/10.1080/17843286.2020.1721131DOI Listing
January 2020

The management of dementia by flemish GPs: it remains a difficult job.

Acta Clin Belg 2020 Jan 30:1-8. Epub 2020 Jan 30.

Department General Practice, University Leuven, Belgium.

: The following study examines how GPs in Flanders deal with dementia in terms of detection, diagnosis, care diagnosis and treatment.: An online survey was sent out by mail to 5113 Flemish GP's. Data were collected in 2016. Read More

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http://dx.doi.org/10.1080/17843286.2020.1716462DOI Listing
January 2020

The heart remembers what the mind forgets.

Acta Clin Belg 2020 Jan 30:1-4. Epub 2020 Jan 30.

Department of Cardiology, GZA Sint-Augustinus, Antwerp, Belgium.

: Cardiac memory, also known as the Chatterjee phenomenon, is a poorly understood, under-recognized but important and benign cause of T-wave inversions. After a period of abnormal ventricular activation, such as ventricular pacing, intermittent left bundle branch block or pre-excitation, the heart 'remembers' and mirrors its repolarization in the direction of the previous QRS. It usually manifests as T-wave inversions that can linger up to weeks after the provocative event. Read More

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http://dx.doi.org/10.1080/17843286.2020.1724449DOI Listing
January 2020

Meningitis caused by Campylobacter jejuni: a case presentation and literature review.

Acta Clin Belg 2020 Jan 28:1-6. Epub 2020 Jan 28.

School of Medicine University of Zagreb, Zagreb, Croatia.

: is one of the most common causative agents of gastroenteritis; however meningitis is rarely described. Therefore, little is known about its epidemiology, clinical presentation, diagnostic methods, treatment, and outcomes.: In this paper, we report a case of an adult patient with meningitis. Read More

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http://dx.doi.org/10.1080/17843286.2020.1721133DOI Listing
January 2020