4,328 results match your criteria Acta clinica Belgica[Journal]


A model-based economic evaluation of four newborn screening strategies for cystic fibrosis in Flanders, Belgium.

Acta Clin Belg 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Interuniversity Center for Health Economics Research , Vrije Universiteit Brussel , Brussels , Belgium.

Objectives: The most cost-effective newborn screening strategy for cystic fibrosis (CF) for Flanders, Belgium, is unknown. The aim of this study was to assess the cost-effectiveness of four existing newborn screening strategies for CF: IRT-DNA (immunoreactive trypsinogen, cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation analysis), IRT-PAP (pancreatitis-associated protein), IRT-PAP-DNA, and IRT-PAP-DNA-EGA (extended CFTR gene analysis).

Methods: Using data from published literature, the cost-effectiveness of the screening strategies was calculated for a hypothetical cohort of 65,606 newborns in Flanders, Belgium. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2019.1
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http://dx.doi.org/10.1080/17843286.2019.1604472DOI Listing
April 2019
1 Read

Coombs-positive refractory acquired thrombotic thrombocytopenic purpura in a patient with chronic myelomonocytic leukemia successfully treated with rituximab.

Acta Clin Belg 2019 Apr 22:1-5. Epub 2019 Apr 22.

b Intensive Care Unit, Department of Internal Medicine , University Hospital Centre Zagreb , Zagreb , Croatia.

Objectives: Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare autoimmune disorder characterized by auto-antibodies to Willebrand factor (vWF) cleaving enzyme (ADAMTS13), resulting in unusually large vWF multimers that lead to platelet aggregation, microthrombi formation and microangiopathic hemolytic anemia. Hemolysis in aTTP is mechanical; thus, direct antiglobulin test (Coombs test) is usually negative. Multiple autoimmune conditions and various auto-antibodies have been described in the context of chronic myelomonocytic leukemia (CMML). Read More

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http://dx.doi.org/10.1080/17843286.2019.1608395DOI Listing

Shifting specialized oncological care from hospital- to home-setting: is there support among patients, specialists and general practitioners?

Acta Clin Belg 2019 Apr 19:1-8. Epub 2019 Apr 19.

a Cancer Centre , General Hospital Groeninge , Kortrijk , Belgium.

Objectives: Oncological home-hospitalization (OHH) might be a patient-centred approach to deal with the increasing burden of cancer on health-care facilities and finances. Before implementation into practice, its feasibility, costs and support among stakeholders should be evaluated. The purpose of this trial was to explore patients', specialists' and general practitioners' (GPs) perspectives towards the opportunities of implementing OHH within the Belgian health-care system. Read More

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http://dx.doi.org/10.1080/17843286.2019.1605467DOI Listing

Left atrium size and red cell distribution width predict atrial fibrillation progression from paroxysmal or persistent to permanent.

Acta Clin Belg 2019 Apr 5:1-7. Epub 2019 Apr 5.

f Department of Cardiology , University Hospital Merkur , Zagreb , Croatia.

Objective: Stratifying patients with paroxysmal or short-term persistent atrial fibrillation (AF) who are at greater risk of developing permanent AF is challenging. Aim of our prospective study was to evaluate association of laboratory parameters (biochemistry and complete blood count (CBC)) together with standard demographic, clinical and echocardiography parameters, with AF progression.

Methods: We prospectively recruited 579 patients with AF and divided them into two groups at index hospitalization: paroxysmal or persistent (non-permanent AF), and long-term persistent or permanent AF patients (permanent AF). Read More

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http://dx.doi.org/10.1080/17843286.2019.1599173DOI Listing
April 2019
1 Read

Overlooked guide wire: a multicomplicated Swiss Cheese Model example. Analysis of a case and review of the literature.

Acta Clin Belg 2019 Mar 30:1-7. Epub 2019 Mar 30.

a Emergency department , CHU UCL Namur , Yvoir , Belgium.

Objectives: Central venous catheter (CVC) implementation is now usual in emergency department. The most common complications are misplacement, bleeding, pleural perforation, thrombosis and sepsis. Forgetting a guide wire in the patient's body after catheterization is an underestimated complication of this procedure; only 76 cases are described. Read More

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http://dx.doi.org/10.1080/17843286.2019.1592738DOI Listing
March 2019
1 Read

Hyperferritinemia associated with systemic manifestations of Mycoplasma pneumoniae infection.

Acta Clin Belg 2019 Mar 28. Epub 2019 Mar 28.

a Department of Internal Medicine , Universitair Ziekenhuis Gent , Ghent , Belgium.

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http://dx.doi.org/10.1080/17843286.2019.1599569DOI Listing

Hyperferritinemia, vasculitis and Mycoplasma pneumoniae.

Authors:
Dimitri Poddighe

Acta Clin Belg 2019 Mar 28. Epub 2019 Mar 28.

a Department of Medicine , Nazarbayev University School of Medicine , Astana , Kazakhstan.

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http://dx.doi.org/10.1080/17843286.2019.1599549DOI Listing

A rare case of hemodialysis-related portosystemic encephalopathy and review of the literature.

Acta Clin Belg 2019 Mar 28:1-5. Epub 2019 Mar 28.

b Department of Gastro-enterology and Hepatology , University Hospital of Antwerp , Edegem , Belgium.

Hemodialysis-related portosystemic encephalopathy (HRPSE) is a clinical phenomenon where portosystemic encephalopathy (PSE) develops without liver dysfunction, usually caused by changes in the portosystemic blood flow related to hemodialysis. We describe the case of a 22-year old patient with a transjugular intrahepatic portosystemic shunt (TIPS) who developed HRPSE several months after initiation of hemodialysis. Despite initial therapy with laxatives and neomycin symptoms recurred. Read More

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http://dx.doi.org/10.1080/17843286.2019.1595836DOI Listing
March 2019
2 Reads

An important problem in an aging country: identifying the frailty via 9 Point Clinical Frailty Scale.

Acta Clin Belg 2019 Mar 28:1-5. Epub 2019 Mar 28.

a Faculty of Medicine, Department of Internal Medicine Division of Geriatrics , Hacettepe University , Ankara , Turkey.

Objectives: Frailty is a geriatric syndrome which develops as a result of cumulative decline in many physiological systems and results in an increased vulnerability and risk of adverse outcomes. The Clinical Frailty Scale (CFS) was validated as a predictor of adverse outcomes in community-dwelling older people and evaluates items such as comorbidity, cognitive impairment and disability. We aimed to study the concurrent and construct validity and reliability of the 9 point CFS in Turkish Population. Read More

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http://dx.doi.org/10.1080/17843286.2019.1597457DOI Listing
March 2019
4 Reads

Past, present and future of university hospitals.

Acta Clin Belg 2019 Mar 21:1-8. Epub 2019 Mar 21.

b General management , Ghent University Hospital , Ghent , Belgium.

Objectives: Health care systems worldwide are changing and taking new forms. The old, more hierarchically oriented, model with individual institutional and bilateral interactions between primary, secondary, tertiary and quaternary care is being replaced by an integrated and dynamic network model. We aim to look at what role university hospitals will play in this future organization of health care. Read More

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http://dx.doi.org/10.1080/17843286.2019.1590024DOI Listing
March 2019
1 Read

The effect of selenium and zinc on CD4(+) count and opportunistic infections in HIV/AIDS patients: a randomized double blind trial.

Acta Clin Belg 2019 Mar 19:1-7. Epub 2019 Mar 19.

a Tehran University of Medical Sciences , Tehran , Iran.

Objectives: We assessed the effect of selenium and zinc supplementation on CD4 cell count and the risk of developing opportunistic infections.

Methods: In a double blind clinical trial, 146 HIV(+) patients receiving combination antiretroviral therapy with CD4(+) >200/cubic millimeter were screened for comorbidities and opportunistic infections, and randomized to receive daily selenium (200 µg), zinc (50 mg) or placebo for 6 months, before a 3-month follow-up period. CD4 cell counts were measured in the 3, 6 and 9 months. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2019.1
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http://dx.doi.org/10.1080/17843286.2019.1590023DOI Listing
March 2019
6 Reads

How dyspepsia led to the diagnosis of Morbus Crohn.

Acta Clin Belg 2019 Mar 18:1-3. Epub 2019 Mar 18.

b Department of Gastroenterology , University hospital Gasthuisberg , Leuven , Belgium.

Background: It is well known that Crohn's disease can involve the stomach. However, most often this upper gastrointestinal tract involvement is asymptomatic. Typically, there is involvement of the small intestine with the typical associated symptoms of Crohn's disease: abdominal cramps, diarrhoea and weight loss. Read More

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http://dx.doi.org/10.1080/17843286.2019.1590497DOI Listing
March 2019
1 Read

Human psittacosis: a review with emphasis on surveillance in Belgium.

Acta Clin Belg 2019 Mar 18:1-7. Epub 2019 Mar 18.

a Laboratory for Immunology and Animal Biotechnology , Ghent University , Ghent , Belgium.

Chlamydia psittaci causes psittacosis in humans, mainly in persons in contact with birds in either the setting of occupational or companion bird exposure. Infection is associated with a range of clinical manifestations from asymptomatic infection to severe atypical pneumonia and systemic disease. This paper reviews new knowledge on psittacosis, its legal and regulatory aspects and presents epidemiological data on psittacosis in Belgium. Read More

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http://dx.doi.org/10.1080/17843286.2019.1590889DOI Listing
March 2019
2 Reads

Clinical and biochemical differences between hantavirus infection and leptospirosis: a retrospective analysis of a patient series in Belgium.

Acta Clin Belg 2019 Mar 18:1-8. Epub 2019 Mar 18.

a Department of General Internal Medicine , UZ Leuven , Leuven , Belgium.

Objectives: Hantavirus infection and leptospirosis are infectious diseases transmitted by rodents. The clinical picture is nonspecific, often involving the kidneys but other organs can be affected too. Clinical and biochemical clues to make a difference between these two entities will be described. Read More

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http://dx.doi.org/10.1080/17843286.2019.1591654DOI Listing

The human microbiome in health and disease: hype or hope.

Acta Clin Belg 2019 Apr 27;74(2):53-64. Epub 2019 Feb 27.

a Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology , Rega Institute, KU Leuven , Leuven , Belgium.

Objectives: The prognostic, diagnostic, and therapeutic potential of the human gut microbiota is widely recognised. However, translation of microbiome findings to clinical practice is challenging. Here, we discuss current knowledge and applications in the field. Read More

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http://dx.doi.org/10.1080/17843286.2019.1583782DOI Listing

A practical approach towards the evaluation of aberrant thyroid function tests.

Acta Clin Belg 2019 Feb 26:1-8. Epub 2019 Feb 26.

b Department of Clinical Pathology , Ghent University Hospital , Ghent , Belgium.

Objective: To provide insight in patterns and causes of aberrant thyroid function tests (TFT) and to propose a practical approach for clinicians.

Methods: Starting from an illustrative case report, an extensive literature search was performed, resulting in a narrative literature review.

Results: TFT that cannot be explained by the negative feedback principle of the hypothalamo-pituitary-thyroid axis are a challenge for every clinician. Read More

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http://dx.doi.org/10.1080/17843286.2019.1577531DOI Listing
February 2019
1 Read

Rituximab prescription patterns and efficacy in the induction treatment of ANCA-Associated Vasculitis in a Belgian multicenter cohort.

Acta Clin Belg 2019 Feb 15:1-7. Epub 2019 Feb 15.

a Internal Medicine, Erasme Hospital , Université Libre de Bruxelles , Anderlecht , Belgium.

Introduction: The RAVE trial has revolutionized induction treatment of anti-neutrophil cytoplasmic antibodies (ANCA)-Associated Vasculitis (AAV)by demonstrating the non-inferiority of rituximab (RTX) compared with cyclophosphamide.

Objectives: We studied AAV patients' characteristics, RTX prescription practices and efficacy in AAV induction treatment in four Belgian university hospitals. The patient population, selected according to the Belgian reimbursement criteria, was relatively homogeneous and comparable to the one of RAVE trial. Read More

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http://dx.doi.org/10.1080/17843286.2019.1578041DOI Listing
February 2019

A plethora of manifestations following a Mycoplasma pneumoniae infection: a case report.

Acta Clin Belg 2019 Feb 15:1-6. Epub 2019 Feb 15.

e Department of Gastroenteroly , AZ Maria Middelares , Ghent , Belgium.

Mycoplasma pneumoniae infection can present with a plethora of symptoms and result in a systemic vasculitis by activating a cascade of autoimmune reactions. In this case report, a young man without relevant past medical history was admitted to the hospital with diarrhea, abdominal pain and spiking fever. A CT-scan showed terminal ileitis. Read More

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http://dx.doi.org/10.1080/17843286.2019.1578029DOI Listing
February 2019
1 Read

Relation between serum cotinine levels and trophic lesions in patients with critical limb ischemia: a pilot study.

Acta Clin Belg 2019 Feb 11:1-6. Epub 2019 Feb 11.

a Department of Medical Informatics and Biostatistics , Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca , Cluj-Napoca , Romania.

Aim: To evaluate if smoking, quantified by the serum cotinine levels, is related to the evolution of patients with critical limb ischemia (CLI).

Method: A pilot study was conducted on CLI patients who addressed at the Second Surgery Clinic of the Emergency County Hospital, Cluj-Napoca, Romania between November 2015 and December 2016. The sample of patients was split into two groups using the threshold of 15 ng/mL for the serum level of cotinine (low cotinine level - LCL vs. Read More

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http://dx.doi.org/10.1080/17843286.2019.1577530DOI Listing
February 2019
1 Read

A rare cause of recurrent hemopneumothorax.

Acta Clin Belg 2019 Feb 5:1-3. Epub 2019 Feb 5.

a Department of Pulmonology and Thoracic Oncology , Jessa Hospital , Hasselt , Belgium.

Background: Angiosarcoma is a rare and aggressive tumor of vascular endothelial origin. Pulmonary metastasis can lead to potential life-threatening complications, such as bleeding and pneumothorax.

Methods: We report on a 82-year-old male with major hemoptysis, recurrent hemopneumothorax and cystic lung lesions. Read More

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http://dx.doi.org/10.1080/17843286.2019.1578030DOI Listing
February 2019
1 Read

Detection of potentially inappropriate prescribing in older patients with the GheOP³S-tool: completeness and clinical relevance.

Acta Clin Belg 2019 Apr 30;74(2):126-136. Epub 2019 Jan 30.

e Department of Pharmacy , Ghent University Hospital , Gent , Belgium.

Objectives: The Ghent Older People's Prescriptions community Pharmacy Screening (GheOPS-) tool was recently developed as an explicit screening method to detect Potentially Inappropriate Prescribing (PIP) in the community pharmacy. We aimed to validate the GheOPS-tool as an effective screening method for PIP.

Methods: All patients admitted to the acute geriatric ward of the Sint-Vincentius hospital (Belgium) were consecutively screened for inclusion (≥70 years,≥5 drugs chronically). Read More

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http://dx.doi.org/10.1080/17843286.2019.1568353DOI Listing

Health literacy among asthma patients and treatment expectations: results of a Belgian survey.

Acta Clin Belg 2019 Jan 14:1-8. Epub 2019 Jan 14.

d Department of Respiratory Medicine , Ghent University Hospital , Gent , Belgium.

Objectives: Non-adherence to asthma medication can lead to lower disease control and asthma exacerbations that may be fatal. This survey assessed the attitude and expectations of Belgian asthma patients towards their treatment.

Methods: This cross-sectional survey was conducted between June 2015 and February 2016 in 70 Belgian pharmacies. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
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http://dx.doi.org/10.1080/17843286.2018.1564543DOI Listing
January 2019
8 Reads

Teledermatology in Belgium: a pilot study.

Acta Clin Belg 2019 Jan 8:1-7. Epub 2019 Jan 8.

b Department of Dermatology , Ghent University , Ghent , Belgium.

Background: Teledermatology, the application of telemedicine in the field of dermatology, can be a valuable tool to improve the efficiency of care in general practice.

Objectives: In this pilot study, we implemented a teledermatology programme in Belgian context to assess the effect on referral rate and to evaluate the acceptability of teledermatology by clinicians and patients.

Material And Methods: A store-and-forward teledermatology service between 12 general practitioners (GPs) and 3 academic dermatologists was evaluated for a period of 3-6 months. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
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http://dx.doi.org/10.1080/17843286.2018.1561812DOI Listing
January 2019
7 Reads

Prevalence of vitamin K deficiency in older people with hip fracture.

Acta Clin Belg 2019 Jan 8:1-5. Epub 2019 Jan 8.

a Department of Ageing & Health , Guy's & St. Thomas' NHS Trust , London , UK.

Introduction: Vitamin K plays an important role in blood coagulation. Diet is the main source of vitamin K and body stores are depleted in days, hence deficiency is common in malnourished older people. A high proportion of people who sustain a hip fracture are already malnourished, compounded by fasting for surgery which might further increase deficiency. Read More

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http://dx.doi.org/10.1080/17843286.2018.1564174DOI Listing
January 2019

IgG4-related pleural disease in a patient with a history of unknown origin acute pancreatitis: a case report and review of the literature.

Acta Clin Belg 2019 Jan 8:1-4. Epub 2019 Jan 8.

b Pneumology Department , CHU Liège , Liège , Belgium.

Immunoglobulin G4-related disease is a rare autoimmune systemic disease with the capability of involving every organ. The disease is microscopically defined by a diffuse tissular inflammation with an infiltration of IgG4 positive plasma cells in the affected organs. IgG4 disease has an increasing incidence in the last few years with a growing interest in its pathophysiology still misunderstood to date. Read More

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http://dx.doi.org/10.1080/17843286.2018.1564173DOI Listing
January 2019
1 Read

Neutropenia management in patients receiving myelosuppressive polychemotherapy for early breast cancer in Belgium: BRONS study results.

Acta Clin Belg 2019 Jan 4:1-8. Epub 2019 Jan 4.

a Department of Medical Oncology, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Institut Roi Albert II , Université catholique de Louvain , Brussels , Belgium.

Background: Chemotherapy plays an important role in the treatment of early breast cancer (EBC). Granulocyte-colony stimulating factors (G-CSF) can reduce the risk of febrile neutropenia as primary prophylaxis (PP) or secondary prophylaxis (SP). The BRONS study investigated the incidence of serious neutropenic events (SNE) and G-CSF use in a Belgian population of EBC patients treated with myelosuppressive polychemotherapy. Read More

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http://dx.doi.org/10.1080/17843286.2018.1563735DOI Listing
January 2019
2 Reads

Sociodemographic factors and strategies in colorectal cancer screening: a narrative review and practical recommendations.

Acta Clin Belg 2019 Jan 4:1-9. Epub 2019 Jan 4.

a Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium.

Background: Worldwide colorectal cancer is a frequently occurring cancer with a high disease burden. It is the second most frequent cancer in women and the third in men. The incidence of colorectal cancer is increasing because of ageing and unhealthy lifestyles. Read More

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http://dx.doi.org/10.1080/17843286.2018.1563736DOI Listing
January 2019
1 Read

"Mind the gap please…": estimated vs. measured Ac from continuous measurement of interstitial glucose over a 3-month period in patients with type 1 diabetes.

Acta Clin Belg 2018 Dec 31:1-7. Epub 2018 Dec 31.

b Cliniques universitaires Saint-Luc , Service d'Endocrinologie et Nutrition , Brussels , Belgium.

Introduction: Glycated hemoglobin (A) is the measurement of choice to estimate the glycemic exposure over the last 3 months prior to sampling. The Free Style Libre® is a continuous glucose monitoring device which provides an estimated A (eA1c) from average interstitial glucose using Nathan's ADAG equation. The objective of this study was to compare eA1c and A in type 1 diabetes patients (T1D) over a period of 3 months. Read More

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http://dx.doi.org/10.1080/17843286.2018.1561780DOI Listing
December 2018
4 Reads

Blood lactate and lactate kinetics as treatment and prognosis markers for tissue hypoperfusion.

Acta Clin Belg 2018 Dec 28:1-8. Epub 2018 Dec 28.

a Faculty of Medicine and Health Sciences , Ghent University , Ghent , Belgium.

Objective: Blood lactate concentration (L) and lactate kinetic (LK) over time might be a helpful marker of the shock severity. The purpose of this study is to analyze whether the L and LK could correlate with the outcome and the therapy of patients with different types of shock.

Methods: Design: A 3. Read More

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http://dx.doi.org/10.1080/17843286.2018.1560612DOI Listing
December 2018
1 Read

Clinical biochemistry test eliminator providing cost-effectiveness with five algorithms.

Authors:
Ataman Gönel

Acta Clin Belg 2018 Dec 25:1-5. Epub 2018 Dec 25.

a Department of Medical Biochemistry , Harran University , Sanliurfa , Turkey.

Objectives: The purpose of this study is to investigate the elimination ratios of requested unnecessary tests and the cost-effectiveness to be achieved by means of 5 different algorithms with clinical validity defined in an artificial intelligence program.

Methods: The clinician orders received from the hospital information management system were adapted to eliminate AST, direct bilirubin, chlorine, fPSA and fT3 tests using five different algorithms defined in the ALIN IQ software.

Results: In this study, 18387 AST, 9500 direct bilirubin, 61 free PSA, 1127 FT3 and 11172 chlorine tests that were ordered within 45 days were eliminated using 5 different algorithms defined in the ALIN IQ software in the Laboratory of Harran University Faculty of Medicine. Read More

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http://dx.doi.org/10.1080/17843286.2018.1563324DOI Listing
December 2018

The impact of familial predisposition on the development of Hashimoto's thyroiditis.

Acta Clin Belg 2018 Dec 20:1-5. Epub 2018 Dec 20.

a Department of Oncology and Nuclear Medicine , University Hospital Center "Sestre Milosrdnice" , Zagreb , Croatia.

Objectives: Hashimoto's thyroiditis (HT) is a common autoimmune disease. Available data show that HT develops as a result of interaction between genetic susceptibility and environmental factors, but the exact pathogenesis of the disease is not yet fully understood. The aim of this investigation is to evaluate the potential relationship between family history of HT and the development of HT. Read More

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http://dx.doi.org/10.1080/17843286.2018.1555115DOI Listing
December 2018
1 Read

Hypotonia and delayed motor development as an early presentation of Lowe syndrome: case report and literature review.

Acta Clin Belg 2018 Dec 3:1-5. Epub 2018 Dec 3.

a Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology , Ghent University Hospital , Ghent , Belgium.

We describe a boy who presented with neonatal hypotonia, followed by delayed motor development and growth impairment. Further evaluation revealed rickets caused by proximal renal tubular dysfunction. At age 3, the boy exhibited dysmorphic features and bilateral cataract. Read More

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http://dx.doi.org/10.1080/17843286.2018.1551743DOI Listing
December 2018
1 Read

First case of Candida auris infection in Belgium in a surgical patient from Kuwait.

Acta Clin Belg 2018 Dec 4:1-8. Epub 2018 Dec 4.

c Department of Microbiology and Immunology , KU Leuven , Leuven , Belgium.

Objective And Importance: Candida auris is a relatively new yeast species and an emerging opportunistic pathogen. It was first reported in 2009 in East Asia, as a difficult-to-identify Candida species of uncertain clinical relevance. In recent years, it has appeared globally as a cause of invasive infections, not infrequently eliciting nosocomial outbreaks. Read More

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http://dx.doi.org/10.1080/17843286.2018.1555114DOI Listing
December 2018
5 Reads

Epidemiology and clinical management of HIV-HBV coinfected patients in a large AIDS Reference Center in Belgium.

Acta Clin Belg 2018 Dec 4:1-6. Epub 2018 Dec 4.

b Department of Infectious Diseases , Saint-Pierre University Hospital , Brussels ,
 Belgium.

Objectives: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are both worldwide health concerns with similar routes of transmission and no curative treatment to date. Coinfection is associated with increased morbidity and mortality. We aim to provide epidemiological data about HIV-HBV coinfected patients and asses if management of patients following European recommendation (EACS) was achieved in a large AIDS Reference Center in Belgium. Read More

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http://dx.doi.org/10.1080/17843286.2018.1554292DOI Listing
December 2018
3 Reads

A review of blood usage and wastage in a tertiary heart center.

Acta Clin Belg 2018 Dec 4:1-8. Epub 2018 Dec 4.

b Department of Medical Laboratory Sciences, School of Allied Medical sciences , Mazandaran University of Medical Sciences , Sari , Iran.

Background/objectives: Blood is a vital resource that its utilization is ever increasing throughout the world and blood wastage is a global challenge that needs to be controlled. Most blood resources are used during complications of pregnancy, trauma, severe childhood anemia, gynecology, cancers, surgery, hematology disorders, and chronic diseases. Units that are expired, broken bags, returning the blood unit after 30 min, blood clotted units, etc. Read More

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http://dx.doi.org/10.1080/17843286.2018.1555113DOI Listing
December 2018
166 Reads
0.916 Impact Factor

Bone metastases and age are associated with earlier dose reductions in metastatic clear-cell renal cell carcinoma patients treated with angiogenesis inhibitors.

Acta Clin Belg 2018 Nov 29:1-10. Epub 2018 Nov 29.

a Department of General Medical Oncology , University Hospitals Leuven, KULeuven , Leuven , Belgium.

Background: Metastatic clear-cell renal cell carcinoma (m-ccRCC) patients with bone metastases (BM) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) have a poorer outcome compared to patients without BM. We aimed to investigate whether an increased incidence of VEGFR-TKI treatment interruptions and/or dose reductions in patients with BM could explain this difference in outcome.

Patients And Methods: Retrospective study on m-ccRCC patients treated in first-line with VEGFR-TKI. Read More

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http://dx.doi.org/10.1080/17843286.2018.1551744DOI Listing
November 2018

Electrolytes disturbances after kidney transplantation.

Acta Clin Belg 2018 Nov 27:1-5. Epub 2018 Nov 27.

c Antwerp University Hospital and University of Antwerp , Edegem.

Objectives: Water and electrolytes disturbances often occur in renal transplant recipients. The objective is to describe the pathophysiology and the treatment of the most prevalent abnormalities.

Methods: We screened PubMed for the following words in various combination: kidney transplantation and (disturbances or abnormalities) of (electrolytes or sodium or potassium or phosphate or calcium or acid-base). Read More

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http://dx.doi.org/10.1080/17843286.2018.1549193DOI Listing
November 2018
5 Reads

Abiraterone and spironolactone in prostate cancer: a combination to avoid.

Acta Clin Belg 2018 Nov 26:1-6. Epub 2018 Nov 26.

a Department of Urology , Ghent University Hospital , Ghent , Belgium.

Objectives:  Disease progression in metastatic castration-resistant prostate cancer (mCRPC) is dependent on androgen signaling. This case describes the complex adaptive androgen signaling mechanisms in mCRPC and illustrates that caution should be exercised when treating these patients with drugs influencing the androgen axis.

Methods:  Single case report and review of the literature. Read More

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http://dx.doi.org/10.1080/17843286.2018.1543827DOI Listing
November 2018
4 Reads

Approach to the patient presenting with metabolic acidosis.

Acta Clin Belg 2018 Nov 24:1-7. Epub 2018 Nov 24.

a Renal Division , Ghent University Hospital , Ghent , Belgium.

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http://dx.doi.org/10.1080/17843286.2018.1547245DOI Listing
November 2018
2 Reads

Acid-base and electrolyte disturbances in patients with diabetes mellitus.

Acta Clin Belg 2019 Feb 23;74(1):28-33. Epub 2018 Nov 23.

a Departments of Nephrology , Universitair Ziekenhuis Brussel , Brussels , Belgium.

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http://dx.doi.org/10.1080/17843286.2018.1546983DOI Listing
February 2019
1 Read

Two cases of glutaric aciduria type II: how to differentiate from inflammatory myopathies?

Acta Clin Belg 2018 Nov 19:1-5. Epub 2018 Nov 19.

b Faculty of Medicine, Department of Rheumatology , Hacettepe University , Ankara , Turkey.

Muscle weakness is a nonspecific finding of myopathy of any etiology that include iatrogenic, toxic, endocrinological, infectious, immunologic, and metabolic disorders. Among the metabolic myopathies glutaric aciduria type II (GAII) is an autosomal recessively inherited rare disorder of fatty acid and amino acid metabolisms. The late onset form is heterogeneous in terms of symptomatology and severity and for the cases that chronic manifestations of lipid storage myopathy are the only clues for the disease, differential diagnosis can be challenging. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
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http://dx.doi.org/10.1080/17843286.2018.1547244DOI Listing
November 2018
17 Reads

Telomerase-related monogenic lung fibrosis presenting with subacute onset: a case report and review of literature

Acta Clin Belg 2018 11 19:1-6. Epub 2018 Nov 19.

a Service de pneumologie , Cliniques Universitaires Saint-Luc , Brussels , Belgium.

Objectives: Monogenic pulmonary fibrosis related to telomerase mutations is characterized by a large spectrum of clinical presentations. The disease may affect several organs including bone marrow, liver and skin. This case illustrates some of the most salient features of telomere-related Interstitial Lung Disease(ILD). Read More

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http://dx.doi.org/10.1080/17843286.2018.1545375DOI Listing
November 2018
13 Reads

Methicillin-resistant staphylococcus aureus pneumonia in older people: a diagnostic and therapeutic challenge.

Acta Clin Belg 2018 Nov 16:1-4. Epub 2018 Nov 16.

a Department of Internal Medicine , University Hospital Ghent , Ghent , Belgium.

Pneumonia is one of the leading causes of death in older people, with high mortality rates (> 80%). One of the bacterial pathogens causing pneumonia is Staphylococcus aureus. The unique adaptive ability of S. Read More

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http://dx.doi.org/10.1080/17843286.2018.1547854DOI Listing
November 2018
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Positional obstructive sleep apnoea: challenging findings in consecutive patients treated with a vibrating position trainer.

Acta Clin Belg 2018 Nov 15:1-9. Epub 2018 Nov 15.

a Leuven University Centre for Sleep and Wake Disorders (LUCS) , University Hospitals Leuven , Leuven , Belgium.

Objectives: Last years, vibrating devices were introduced to treat positional sleep apnoea (POSA). However, few data exist on determinants of effectiveness and adherence in clinical settings.

Methods: The NightBalance Sleep Position Trainer (SPT) analyses the patient's position during the first 2 nights, starts to build up vibrations during the following 7 and is 100% performant from night 10 on; and, reports on %supine, usage time, number of (responses on) vibrations. Read More

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http://dx.doi.org/10.1080/17843286.2018.1545374DOI Listing
November 2018
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ABSTRACT.

Acta Clin Belg 2018 Nov;73(sup1):1-9

a Belgian Reference Centre for Respiratory Pathogens , University Hospital Antwerp , Belgium.

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http://dx.doi.org/10.1080/17843286.2018.1538724DOI Listing
November 2018
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Chimeric antigen receptor T-cell therapy: design improvements and therapeutic strategies in cancer treatment.

Acta Clin Belg 2018 Nov 13:1-7. Epub 2018 Nov 13.

a Department of Hematology , Ghent University Hospital , Ghent , Belgium.

Objectives: To summarize important findings from research on chimeric antigen receptor (CAR) T-cell immunotherapy in cancer. We discuss CAR design, cell products, toxicity management, heterogenous solid tumors and allogeneic transfer.

Methods: A review of literature was conducted. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
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http://dx.doi.org/10.1080/17843286.2018.1545373DOI Listing
November 2018
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Take three, test one: a cross-sectional study to evaluate the molecular detection of Chlamydia trachomatis and Neisseria gonorrhoeae in pooled pharyngeal, anorectal and urine samples versus single-site testing among men who have sex with men in Belgium.

Acta Clin Belg 2018 Nov 12:1-5. Epub 2018 Nov 12.

a HIV/STI Reference Laboratory, Department of Clinical Sciences , Institute of Tropical Medicine , Antwerp , Belgium.

Objectives: To investigate the efficacy of performing a pooling strategy of triple-anatomical site samples (pharyngeal, anorectal and urine samples) for simultaneous Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) nucleic acid amplification detection.

Methods: A total of 117 specimen sets (pharyngeal, anorectal and urine) were collected from 98 men between 2014 and 2016. Double sampling of pharyngeal, anorectal and urine samples allowed for pooled and unpooled analyses using a multiplex Abbott Real Time CT/NG assay, together with confirmatory PCR testing in case of CT/NG positivity. Read More

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http://dx.doi.org/10.1080/17843286.2018.1545376DOI Listing
November 2018
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Salivary gland performance in autoimmune diseases: review and meta-analysis.

Acta Clin Belg 2018 Oct 30:1-7. Epub 2018 Oct 30.

b Dental Research Center, Dentistry Research Institute, Department of Oral and Maxillofacial Medicine , Faculty of Dentistry , Tehran University of Medical Sciences , Tehran , Iran.

Objectives: Autoimmune diseases include a spectrum of disorders in which immune response to the autoantigens leads to tissue damage or dysfunction. Xerostomia, salivary gland dysfunction and lack of saliva are some common symptoms associated with many autoimmune diseases.

Methods: In this review study, the meta-analysis technique is used to objectively review the relationship between autoimmune diseases and salivary gland dysfunction. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
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http://dx.doi.org/10.1080/17843286.2018.1540164DOI Listing
October 2018
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Streptococcal toxic shock syndrome in a returning traveller.

Acta Clin Belg 2018 Oct 27:1-5. Epub 2018 Oct 27.

c Center for Infectious Diseases ID4C , Military Hospital Queen Astrid , Brussels , Belgium.

Background:  A patient presenting with fever and purpura after a stay in the tropics tempts a physician to make a differential diagnosis mainly focusing on imported diseases. Although the importance of considering a tropical disease is obvious, the fact that cosmopolitan infections account for one third of the cases in a febrile returning traveler must not be overseen. Toxic Shock Syndrome is amongst the most notorious diseases due to the high mortality when inappropriately managed and the association with necrotizing fasciitis. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
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http://dx.doi.org/10.1080/17843286.2018.1539634DOI Listing
October 2018
18 Reads