5,972 results match your criteria Acta biomaterialia[Journal]


In vivo and in vitro bioactivity of a "precursor of apatite" treatment on polyetheretherketone.

Acta Biomater 2019 Apr 19. Epub 2019 Apr 19.

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

We recently developed a surface treatment, "precursor of apatite" (PrA), for polyetheretherketone (PrA-PEEK) via a simple, low-temperature process aiming to achieve stronger and faster adhesion to bone. The treatment involves three steps: HSO immersion, exposure to O plasma discharge, and alkaline simulated body fluid (alkaline SBF) treatment. This method produces homogeneous fine particles of amorphous calcium phosphate on the PEEK, and we confirmed that PrA-PEEK had excellent apatite formation ability in an SBF immersion test. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.041DOI Listing
April 2019
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Thermal insulation design bioinspired by microstructure study of penguin feather and polar bear hair.

Acta Biomater 2019 Apr 18. Epub 2019 Apr 18.

International Centre of Electron Microscopy for Materials Science, Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Poland; AGH University of Science and Technology, Al. A. Mickiewicza 30, 30-059 Kraków, Poland. Electronic address:

Nature is an amazing source of inspiration for the design of thermal insulation strategies, which are key for saving energy. In nature, thermal insulation structures, such as penguin feather and polar bear hair, are well developed; enabling the animals' survival in frigid waters. The detailed microscopy investigations conducted in this study, allowed us to perform microstructural analysis of these thermally insulating materials, including statistical measurements of keratin fiber and pore dimensions directly from high resolution Scanning Electron Microscope (SEM) images. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.031DOI Listing

Downstream Platelet Adhesion and Activation Under Highly Elevated Upstream Shear Forces.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Department of Bioengineering, University of Utah, Salt Lake City, USA. Electronic address:

Elevated shear force caused by an anastomotic stenosis is a common complication at the blood vessel-vascular implant interface. Although elevated shear forces were found to cause platelet aggregation around a stenotic region, transient platelet exposure to elevated shear forces and subsequent downstream events occurring under lower shear force were not extensively studied. We hypothesize that effects of elevated shear forces on pre-activation of platelets for downstream adhesion and activation are relevant in understanding the increased thrombotic risk associated with blood-contacting devices. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.028DOI Listing

A Microparticle Approach for Non-viral Gene Delivery within 3D Human Mesenchymal Stromal Cell Aggregates.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706, USA; Materials Science Program, University of Wisconsin, Madison, WI 53706, USA; Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI 53705, USA; AO Foundation Collaborative Research Center, Davos, Switzerland. Electronic address:

Three-dimensional (3D) multicellular aggregates, in comparison to two-dimensional monolayer culture, can provide tissue culture models that better recapitulate the abundant cell-cell and cell-matrix interactions found in vivo. In addition, aggregates are potentially useful building blocks for tissue engineering. However, control over the interior aggregate microenvironment is challenging due to inherent barriers for diffusion of biological mediators (e. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.038DOI Listing

Microstructured Hydrogel Scaffolds Containing Differential Density Interfaces Promote Rapid Cellular Invasion and Vascularization.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Bioregenerative Medicine & Surgery, Division of Plastic Surgery, Weill Cornell Medical Center, 1300 York, Room A-821, New York, NY 10021, United States; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 121A Weill Hall, Ithaca, NY 14853, United States. Electronic address:

Introduction: Insufficient vascularization of currently available clinical biomaterials has limited their application to optimal wound beds. We designed a hydrogel scaffold with a unique internal microstructure of differential collagen densities to induce cellular invasion and neovascularization.

Methods: Microsphere scaffolds (MSS) were fabricated by encasing 1% (w/v) type 1 collagen microspheres 50-150 μm in diameter in 0. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.027DOI Listing

Integration of biological systems with electronic-mechanical assemblies.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA; Department of Engineering Science and Mechanics, and Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. Electronic address:

Biological systems continuously interact with the surrounding environment because they are dynamically evolving. The interaction is achieved through mechanical, electrical, chemical, biological, thermal, optical, or a synergistic combination of these cues. To provide a fundamental understanding of the interaction, recent efforts that integrate biological systems with the electronic-mechanical assemblies create unique opportunities for simultaneous monitoring and eliciting the responses to the biological system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.032DOI Listing
April 2019
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Calcium Carbonate: Adored and Ignored in Bioactivity Assessment.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Unit of Dental Physical Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom.

The title of this article could sound a bit curious to some readers since a layer of apatite - and not calcium carbonate - is well-known to form on the surface of bioactive glasses upon immersion in simulated body fluids. However, calcium carbonate (commonly reported as calcite crystals) can form on the surface of bioactive glasses as well, instead of or in competition with hydroxyapatite, during in vitro tests. Major factors that govern calcium carbonate formation are a high concentration of Ca ions in the testing solution - and, in this regard, glass composition/texture and type of medium play key roles - along with the volume of solution used during in vitro tests. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.039DOI Listing
April 2019
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Fabricated Tropoelastin-Silk Yarns and Woven Textiles for Diverse Tissue Engineering Applications.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Charles Perkins Centre, University of Sydney, NSW 2006, Australia; School of Life and Environmental Sciences, University of Sydney, NSW 2006, Australia; Bosch Institute, University of Sydney, NSW 2006, Australia. Electronic address:

Electrospun yarns offer substantial opportunities for the fabrication of elastic scaffolds for flexible tissue engineering applications. Currently available yarns are predominantly made of synthetic elastic materials. Thus scaffolds made from these yarns typically lack cell signaling cues. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.029DOI Listing

The addition of silver affects the deformation mechanism of a twinning-induced plasticity steel: Potential for thinner degradable stents.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

Laboratory for Biomaterials and Bioengineering, Canada Research Chair I in Biomaterials and Bioengineering for the Innovation in Surgery, Department of Min-Met-Materials Engineering, Research Center of CHU de Quebec, Division of Regenerative Medicine, Laval University, Quebec City, QC G1V 0A6, Canada. Electronic address:

While Fe-based alloys have already been reported to possess all mechanical properties required for vascular stenting, their relatively low degradation rate in vivo still constitutes their main bottleneck. The inflammatory reaction generated by a stent is inversely proportional to its mass. Therefore, the tendency in stenting is to lower the section so to reduce the inflammatory reaction. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.030DOI Listing

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

HIPS - Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research (HZI), Saarland University, Universitätscampus E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany. Electronic address:

Predictive in vitro models are valuable alternatives to animal experiments for evaluating the transport of molecules and (nano)particles across biological barriers. In this work, an improved triple co-culture of air-blood barrier was set-up, being exclusively constituted by human cell lines that allowed to perform experiments at air-liquid interface. Epithelial NCI-H441 cells and endothelial HPMEC-ST1. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.037DOI Listing

3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Chitosan (Ch) is used in different biomedical applications to promote tissue repair. However, tissue injury caused by biomaterial implantation lead to the release of danger signals that engage different inflammatory pathways on the host. Different implanted materials activate the inflammasome leading to the modulation of the immune response. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.035DOI Listing
April 2019
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Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 T cells.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands. Electronic address:

Outer membrane vesicles (OMVs) are vesicular nano-particles produced by Gram-negative bacteria that are recently being explored as vaccine vector. The fact that OMVs can be efficiently produced by a hypervesiculating Salmonella typhimurium strain, are packed with naturally-occurring adjuvants like lipopolysaccharides (LPS), and can be engineered to express any antigen of choice, makes them ideal candidates for vaccinology. However, it is unclear whether OMVs induce dendritic cell (DC)-mediated antigen-specific T cell responses and how immune activation is coordinated. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.033DOI Listing

Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat calvarial bone defects.

Acta Biomater 2019 Apr 12. Epub 2019 Apr 12.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China.

Copper-containing bioactive glass nanoparticles (Cu-BG NPs) with designed compositions and sizes were synthesized and incorporated into chitosan(CH)/silk fibroin(SF)/glycerophosphate(GP) composites to prepare injectable hydrogels for cell-free bone repair. The resulting Cu-BG/CH/SF/GP gels were found to exhibit well-defined injectability and to undergo rapid gelation at physiological temperature and pH. They were highly porous and showed the ability to administer Si, Ca and Cu ions at their respective safe doses in a sustained and controlled manner. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.023DOI Listing

Cell membrane engineering with synthetic materials: Applications in cell spheroids, cellular glues and microtissue formation.

Acta Biomater 2019 Apr 13. Epub 2019 Apr 13.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK. Electronic address:

Biologically inspired materials with tunable bio- and physicochemical properties provide an essential framework to actively control and support cellular behavior. Cell membrane remodeling approaches benefit from the advances in polymer science and bioconjugation methods, which allow for the installation of un-/natural molecules and particles on the cells' surface. Synthetically remodeled cells have superior properties and are under intense investigation in various therapeutic scenarios as cell delivery systems, bio-sensing platforms, injectable biomaterials and bioinks for 3D bioprinting applications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193024
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http://dx.doi.org/10.1016/j.actbio.2019.04.013DOI Listing
April 2019
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Endothelin-1 Inhibits Size Dependent Lymphatic Clearance of PEG-Based Conjugates After Intra-Articular Injection into the Rat Knee.

Acta Biomater 2019 Apr 12. Epub 2019 Apr 12.

Department of Orthopaedics, Emory University, 59 Executive Park South, Atlanta, GA, 30329, USA; Atlanta Veteran's Affairs Medical Center, 1670 Clairmont Road, Decatur, GA, 30033, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Room 2127, Atlanta, GA, 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr. NW, Atlanta, GA, 30332, USA. Electronic address:

Clearance of particles from the knee is an essential mechanism to maintain healthy joint homeostasis and critical to the delivery of drugs and therapeutics. One of the limitations in developing disease modifying drugs for joint diseases, such as osteoarthritis (OA), has been poor local retention of the drugs. Enhancing drug retention within the joint has been a target of biomaterial development, however, a fundamental understanding of joint clearance pathways has not been characterized. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193026
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http://dx.doi.org/10.1016/j.actbio.2019.04.025DOI Listing
April 2019
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Construction of vascularized tissue-engineered bone with polylysine-modified coral hydroxyapatite and a double cell-sheet complex to repair a large radius bone defect in rabbits.

Acta Biomater 2019 Apr 12. Epub 2019 Apr 12.

College of Stomatology, Ningxia Medical University, Yinchuan 750004, China.

In this study, the potential of vascularized tissue-engineered bone constructed by a double cell-sheet (DCS) complex and polylysine (PLL)-modified coralline hydroxyapatite (CHA) to repair large radius bone defects was investigated in rabbits. Firstly, the DCS complex was obtained after rabbit adipose-derived mesenchymal stem cell (ADSC) culture was induced. Secondly, PLL-CHA composite scaffolds with different concentrations of PLL were prepared by the soaking and vacuum freeze-drying methods, and then the scaffolds were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, compression performance testing and cytocompatibility evaluation. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.024DOI Listing
April 2019
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Decellularized extracellular matrix bioinks and the external stimuli to enhance cardiac tissue development in vitro.

Acta Biomater 2019 Apr 12. Epub 2019 Apr 12.

Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Namgu, Pohang, Kyungbuk, 37673, Republic of Korea; Powder and Ceramics Division, Korea Institute of Materials Science (KIMS), 797 Changwon-daero, Seongsan-gu, Changwon-si, Gyeongsangnam-do, 51508, Republic of Korea. Electronic address:

Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or tissue regeneration. Using 3D cell printing technology, various hydrogels have been utilized as bioinks to fabricate EHT to date. However, its efficacy has remained limited due to poor functional properties of the cultured cardiomyocytes stemming from a lack of proper microenvironmental cues. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.026DOI Listing
April 2019
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Near-infrared-light induced nanoparticles with enhanced tumor tissue penetration and intelligent drug release.

Acta Biomater 2019 Apr 11. Epub 2019 Apr 11.

Key Laboratory of Functional Polymer Materials of the Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.

Tumor tissue presents much denser and stiffer extracellular matrix (ECM), which can hinder the penetration of most nanoparticles (NPs) and contribute to the tumor cell proliferation. Here, NIR-activated losartan was encapsulated in hollow mesoporous prussian blue nanoparticles (HMPBs) to degrade ECM. The results showed that losartan enhanced the penetration of DOX, 1. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.022DOI Listing

Microstructure-based finite element model of left ventricle passive inflation.

Acta Biomater 2019 Apr 10. Epub 2019 Apr 10.

Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan, USA. Electronic address:

Isolating the role(s) of microstructural pathological features in affecting diastolic filling is important in developing targeted treatments for heart diseases. We developed a microstructure-based constitutive model of the myocardium and implemented it in an efficient open-source finite element modeling framework to simulate passive inflation of the left ventricle (LV) in a representative 3D geometry based on experimentally measured muscle fiber architecture. The constitutive model was calibrated using previous tissue-level biaxial mechanical test data derived from the canine heart and validated with independent sets of measurements made at both the isolated constituent and organ level. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.016DOI Listing

Nitric oxide releasing poly(vinylidene fluoride-co-hexafluoropropylene) films using a fluorinated nitric oxide donor to greatly decrease chemical leaching.

Acta Biomater 2019 Apr 10. Epub 2019 Apr 10.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Nitric oxide (NO) releasing polymers have been widely applied as biomaterials for a variety of biomedical implants and devices. However, the chemical leaching of NO donors and their byproduct species is almost always observed during the application of polymers doped with NO donors, unless the donor is covalently linked to the polymer. Herein, we report the first NO releasing poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) fluorinated copolymer prepared by incorporating a fluorinated S-nitrosothiol as the NO donor. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.021DOI Listing
April 2019
6.025 Impact Factor

The Bone Regeneration Capacity of 3D-Printed Templates in Calvarial Defect Models: A Systematic Review and Meta-Analysis.

Acta Biomater 2019 Apr 10. Epub 2019 Apr 10.

Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, Norway. Årstadveien 19, 5009 Bergen, Norway. Electronic address:

3D-printed templates are being used for bone tissue regeneration (BTR) as temporary guides. In the current review, we analyze the factors considered in producing potentially bioresorbable/degradable 3D-printed templates and their influence on BTR in calvarial bone defect (CBD) animal models. In addition, a meta-analysis was done to compare the achieved BTR for each type of template material (polymer, ceramic or composites). Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.017DOI Listing

Multi-dimensional bioinspired tactics using an engineered mussel protein glue-based nanofiber conduit for accelerated functional nerve regeneration.

Acta Biomater 2019 Apr 9. Epub 2019 Apr 9.

Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea. Electronic address:

Limited regenerative capacity of the nervous system makes treating traumatic nerve injuries with conventional polymer-based nerve grafting a challenging task. Consequently, utilizing natural polymers and biomimetic topologies became obvious strategies for nerve conduit designs. As a bioinspired natural polymer from a marine organism, mussel adhesive proteins (MAPs) fused with biofunctional peptides from extracellular matrix (ECM) were engineered for accelerated nerve regeneration by enhancing cell adhesion, proliferation, neural differentiation, and neurite formation. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.018DOI Listing

Scaffold-mediated non-viral delivery platform for CRISPR/Cas9-based genome editing.

Acta Biomater 2019 Apr 9. Epub 2019 Apr 9.

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, Singapore 308232, Singapore. Electronic address:

Genome editing, especially via the simple and versatile type II CRISPR/Cas9 system, offers an effective avenue to precisely control cell fate, an important aspect of tissue regeneration. Unfortunately, most CRISPR/Cas9 non-viral delivery strategies only utilise micro-/nano-particle delivery methods. While these approaches provide reasonable genomic editing efficiencies, their systemic delivery may lead to undesirable off-target effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193025
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http://dx.doi.org/10.1016/j.actbio.2019.04.020DOI Listing
April 2019
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Corrigendum to "Osteointegration of titanium implant is sensitive to specific nanostructure morphology" [Acta Biomater. 8 (2012), 1976-1989].

Acta Biomater 2019 Apr 6. Epub 2019 Apr 6.

Amrita Institute of Medical Sciences & Research Centre, Amrita Centre for Nanosciences & Molecular Medicine, Amrita Lane, Ponekkara P O, Kochi, Kerala 682041, India. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2019.04.006DOI Listing

F-fluoride as a prognostic indicator of bone regeneration.

Acta Biomater 2019 Apr 6. Epub 2019 Apr 6.

Department of Biomedical Engineering, Lund University, Lund, Sweden; Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden. Electronic address:

Positron emission tomography (PET) is a form of nuclear imaging, which quantitatively assesses the metabolic activity through the uptake of radioactive tracers. F-fluoride is a positron-emitting isotope with high affinity for bone. Despite its potential as a non-invasive measure of bone metabolism, quantitative F-fluoride PET has only been used sparsely in orthopaedic applications. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.008DOI Listing

Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep.

Acta Biomater 2019 Apr 6. Epub 2019 Apr 6.

Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Spain. Electronic address:

Macroporous scaffolds made of a SiO-CaO-PO mesoporous bioactive glass (MBG) and ɛ-polycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Saos 2) and osteoclasts derived from RAW 264.7 macrophages. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.019DOI Listing
April 2019
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Influence of design and postprocessing parameters on the degradation behavior and mechanical properties of additively manufactured Magnesium scaffolds.

Acta Biomater 2019 Apr 5. Epub 2019 Apr 5.

Department of Oral Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.

Magnesium shows promising properties concerning its use in absorbable implant applications such as biodegradability, improved mechanical strength and plastic deformability. Following extensive research, the first fixation and compression screws composed of magnesium rare earth alloys were commercialised, notably in the field of orthopaedic surgery. Preclinical and clinical follow up studies showed, that the rapid degradation of unprotected metallic Magnesium surfaces and concomitant hydrogen gas bursts still raise concern regarding certain surgical indications and need to be further improved. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.012DOI Listing
April 2019
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A computational study of the dual effect of intermittent and continuous administration of parathyroid hormone on bone remodeling.

Acta Biomater 2019 Apr 4. Epub 2019 Apr 4.

F. Joseph Halcomb III, M.D. Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0108, USA. Electronic address:

Bone remodeling is a process known to be governed by constant interactions between osteoblast and osteoclast through complex pathway networks mediated by signaling factors. Experimental studies show that intermittent and continuous administration of PTH/PTHrP led to opposite outcomes in terms of bone mass. To investigate this dual effect of PTH/PTHrP, we develop a computational model based on a simplified signaling pathway network which includes relevant molecular effectors and cells. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.007DOI Listing
April 2019
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Improving the adhesion, flexibility, and hemostatic efficacy of a sprayable polymer blend surgical sealant by incorporating silica particles.

Acta Biomater 2019 Apr 4. Epub 2019 Apr 4.

Department of Chemical and Biomolecular Engineering, University of Maryland, 4418 Stadium Dr., College Park, MD 20742, USA. Electronic address:

Commercially available surgical sealants for internal use either lack sufficient adhesion or produce cytotoxicity. This work describes a surgical sealant based on a polymer blend of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) that increases wet tissue adherence by incorporation of nano-to-microscale silica particles, without significantly affecting cell viability, biodegradation rate, or local inflammation. In functional studies, PLGA/PEG/silica composite sealants produce intestinal burst pressures that are comparable to cyanoacrylate glue (160 mmHg), ∼2 times greater than the non-composite sealant (59 mmHg), and ∼3 times greater than fibrin glue (49 mmHg). Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.015DOI Listing
April 2019
4 Reads

Improved in vivo detection of atherosclerotic plaques with a tissue factor-targeting magnetic nanoprobe.

Acta Biomater 2019 Apr 4. Epub 2019 Apr 4.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, PR China; Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, PR China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address:

Rupture of atherosclerotic plaques causes acute cardiovascular and cerebrovascular pathology. Tissue factor (TF) is a key factor that affects the development of atherosclerotic plaques and the formation of thrombus and thus constitutes a potential target for the detection of atherosclerotic plaques. In this study, the conjugation of the fusion protein 'enhanced green fluorescent protein with the first epidermal growth factor domain' (EGFP-EGF1) and superparamagnetic iron oxide nanoparticles (EGFP-EGF1-SPIONs) was explored for molecular imaging of TF-positive atherosclerotic plaques. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.014DOI Listing
April 2019
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Hexahistidine-metal assemblies: A promising drug delivery system.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, PR China; Wenzhou Institute of Biomaterials and Engineering, CNITECH, CAS, Wenzhou, Zhejiang Province 325001, PR China; Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute of Biomaterials and Engineering, CAS, Wenzhou, Zhejiang Province 325001, PR China. Electronic address:

It is of considerable interest to construct an ideal drug delivery system (i.e., high drug payload, minimal cytotoxicity, rapid endocytosis, and lysosomal escape) under mild conditions for disease treatment, tissue engineering, bioimaging, etc. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.058DOI Listing

Immune tolerance of tissue-engineered skin produced with allogeneic or xenogeneic fibroblasts and syngeneic keratinocytes grafted on mice.

Acta Biomater 2019 Apr 4. Epub 2019 Apr 4.

Centre de recherche du CHU de Québec - Université Laval, Department of Surgery, Faculty of Medicine, Université Laval and Centre de recherche en organogénèse expérimentale de l'Université Laval/LOEX, Canada. Electronic address:

Organs are needed for the long-term replacement of diseased or wounded tissues. Various technologies based on cells seeded in synthetic or biomaterial scaffolds, or scaffold-free methods have been developed in order to produce substitutes that mimic native organs and tissues. For cell-based approaches, the use of living allogeneic fibroblasts could potentially lead to the production of "off-the-shelf" bioengineered organs/tissues. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.010DOI Listing
April 2019
2 Reads

Polymer conjugation optimizes EDTA as a calcium-chelating agent that exclusively removes extrafibrillar minerals from mineralized collagen.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

College of Dental Medicine, The Dental College of Georgia, Augusta, GA, USA. Electronic address:

During development of mineralized collagenous tissues, intrafibrillar mineralization is achieved by preventing mineralization precursor inhibitors that are larger than 40 kDa from entering the collagen fibrils. Such a property is incorporated in the design of a calcium chelator for dentin bonding in the etch-and-rinse technique that selectively demineralizes extrafibrillar apatite while leaving the intrafibrillar minerals intact. This strategy prevents complete demineralization of collagen fibrils, avoids collapse of collagen that blocks resin infiltration after air-drying, and protects the completely demineralized fibrils from bacteria colonization and degradation by endogenous proteases after resin bonding. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.011DOI Listing
April 2019
6.025 Impact Factor

72-Hour in vivo evaluation of nitric oxide generating artificial lung gas exchange fibers in sheep.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

Carnegie Mellon University, United States.

The large, densely packed artificial surface area of artificial lungs results in rapid clotting and device failure. Surface generated nitric oxide (NO) can be used to reduce platelet activation and coagulation on gas exchange fibers, while not inducing patient bleeding due to its short half-life in blood. To generate NO, artificial lungs can be manufactured with PDMS hollow fibers embedded with copper nanoparticles (Cu NP) and supplied with an infusion of the NO donor S-nitroso-N-acetyl-penicillamine (SNAP). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193023
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http://dx.doi.org/10.1016/j.actbio.2019.04.004DOI Listing
April 2019
2 Reads

Kidney regeneration with biomimetic vascular scaffolds based on vascular corrosion casts.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, NC, USA. Electronic address:

We have developed a biomimetic renal vascular scaffold based on a vascular corrosion casting technique. This study evaluated the feasibility of using this novel biomimetic scaffold for kidney regeneration in a rat kidney cortical defect model. Vascular corrosion casts were prepared from normal rat kidneys by perfusion with 10% polycaprolactone (PCL) solution, followed by tissue digestion. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.001DOI Listing
April 2019
2 Reads

In vitro assessment of mixed matrix hemodialysis membrane for achieving endotoxin-free dialysate combined with high removal of uremic toxins from human plasma.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

(Bio)artificial Organs, Department of Biomaterials Science and Technology, TechMed Centre, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. Electronic address:

For a single hemodialysis session nearly 500 L of water are consumed for obtaining pyrogen-free dialysis fluid. However, many efforts are required to avoid biofilm formation in the system and risk of contamination can persist. Water scarcity and inadequate water purification facilities worsen contamination risk in developing countries. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.009DOI Listing
April 2019
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Advances in injectable self-healing biomedical hydrogels.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; MOE Joint International Research Laboratory of CNS Regeneration, Jinan University, Guangzhou 510632, China. Electronic address:

In recent years, implantable biomaterials have attracted significant interest owing to their potentials for use in the therapy of physical defects and traumas. Among the implantable biomaterials, hydrogels have received increasing attention for their tunable structures and good rheological behavior. However, the mechanical failures of traditional gel materials during normal operation remain a serious issue. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.057DOI Listing
April 2019
2 Reads

Oleic acid as the active agent and lipid matrix in cilomilast-loaded nanocarriers to assist PDE4 inhibition of activated neutrophils for mitigating psoriasis-like lesions.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan. Electronic address:

Both phosphodiesterase (PDE4) inhibitors and omega-9 fatty acids show anti-inflammatory activity for treating inflamed skin diseases, but their efficacy remains low. Combinatorial agents are anticipated to offer an advanced strategy for efficient therapy. We prepared cilomilast-loaded oleic acid (OA) nanocarriers to test the inhibitory capability against human neutrophil stimulation and a murine psoriasis model. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.002DOI Listing
April 2019
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6.025 Impact Factor

Graphene oxide substrates with N-cadherin stimulates neuronal growth and intracellular transport.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

Beckman Institute for Advanced Science & Technology, University of Illinois, Urbana-Champaign, United States; Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana-Champaign, United States. Electronic address:

Intracellular transport is fundamental for neuronal function and development and is dependent on the formation of stable actin filaments. N-cadherin, a cell-cell adhesion protein, is actively involved in neuronal growth and actin cytoskeleton organization. Various groups have explored how neurons behaved on substrates engineered to present N-cadherin; however, few efforts have been made to examine how these surfaces modulate neuronal intracellular transport. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193023
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http://dx.doi.org/10.1016/j.actbio.2019.04.005DOI Listing
April 2019
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A natural energy absorbent polymer composite: The equine hoof wall.

Acta Biomater 2019 Apr 3. Epub 2019 Apr 3.

Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, United States; Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, United States. Electronic address:

The equine hoof has been considered as an efficient energy absorption layer that protects the skeletal elements from impact when galloping. In the present study, the hierarchical structure of a fresh equine hoof wall and the energy absorption mechanisms are investigated. Tubules are found embedded in the intertubular matrix forming the hoof wall at the microscale. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.003DOI Listing
April 2019
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Polypyrrole-coated phase-change liquid perfluorocarbon nanoparticles for the visualized photothermal-chemotherapy of breast cancer.

Acta Biomater 2019 Mar 29. Epub 2019 Mar 29.

Chongqing Research Center for Pharmaceutical Engineering, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China. Electronic address:

A theranostic nanoplatform (DTX/PFH@PPy-FA) for multi-modal imaging-guided photothermal-chemotherapy has been constructed. Lipid-perfluorohexane (PFH) nanodroplet loaded with docetaxel (DTX) was coated with a polypyrrole (PPy) shell. Then the folic acid (FA) molecule with active tumor-targeting function was modified on the surface of PPy shell. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.056DOI Listing
March 2019
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Coacervate-mediated exogenous growth factor delivery for scarless skin regeneration.

Acta Biomater 2019 Mar 29. Epub 2019 Mar 29.

Division of Bioengineering, Incheon National University, Incheon, Republic of Korea. Electronic address:

Although there are numerous medical applications to recover damaged skin tissue, scarless wound healing is being extensively investigated to provide a better therapeutic outcome. The exogenous delivery of therapeutic growth factors (GFs) is one of the engineering strategies for skin regeneration. This study presents an exogenous GF delivery platform developed using coacervates (Coa), a tertiary complex of poly(ethylene argininyl aspartate diglyceride) (PEAD) polycation, heparin, and cargo GFs (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193022
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http://dx.doi.org/10.1016/j.actbio.2019.03.052DOI Listing
March 2019
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Rapid 3D printing of functional nanoparticle-enhanced conduits for effective nerve repair.

Acta Biomater 2019 Mar 28. Epub 2019 Mar 28.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610065, China.

Nerve conduits provide an advanced tool for repairing the injured peripheral nerve that often causes disability and mortality. Currently, the efficiency of conduits in repairing peripheral nerve is unsatisfying. Here, we show a functional nanoparticle-enhanced nerve conduit for promoting the regeneration of peripheral nerves. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.047DOI Listing

Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy.

Acta Biomater 2019 Mar 28. Epub 2019 Mar 28.

Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

Immunotherapy based on checkpoint blockade has been regarded as one of the most promising approaches towards many types of cancers. However, low response rate hinders its application due to insufficient tumor immunogenicity and immunosuppressive tumor microenvironment. To achieve an overall enhanced therapeutic outcome, we developed a dual-functional immuno-stimulatory polymeric prodrug carrier modified with pendent indoximod, an indoleamine 2,3-dioxygenase (IDO) inhibitor that can be used to reverse immune suppression, for co-delivery of Doxorubicin (Dox), a hydrophobic anticancer agent that can promote immunogenic cell death (ICD) and elicit antitumor immunity. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.048DOI Listing
March 2019
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Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials.

Acta Biomater 2019 Mar 29. Epub 2019 Mar 29.

Department of Biomedical Engineering, University of North Texas, TX, USA. Electronic address:

Zinc (Zn) has recently emerged as a promising biodegradable metal thanks to its critical physiological roles and promising degradation behavior. However, cytocompatibility and antibacterial property of Zn is still suboptimal, in part, due to the excessive Zn ions released during degradation. Inspired by the calcium phosphate-based minerals in natural bone tissue, zinc phosphate (ZnP) coatings were prepared on pure Zn using a chemical conversion method in this study. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.055DOI Listing

Role of mechanical flow for actin network organization.

Acta Biomater 2019 Mar 27. Epub 2019 Mar 27.

School of Mechanical Engineering, Yonsei University, Seoul 03722, Republic of Korea. Electronic address:

The major cytoskeletal protein actin forms complex networks to provide structural support and perform vital functions in cells. In vitro studies have revealed that the structure of the higher-order actin network is determined primarily by the type of actin binding protein (ABP). By comparison, there are far fewer studies about the role of the mechanical environment for the organization of the actin network. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.054DOI Listing
March 2019
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Mechanical damage characterization in human femoropopliteal arteries of different ages.

Acta Biomater 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Endovascular treatment of Peripheral Arterial Disease (PAD) is notorious for high failure rates, and interaction between the arterial wall and the repair devices plays a significant role. Computational modeling can help improve clinical outcomes of these interventions, but it requires accurate inputs of elastic and damage characteristics of the femoropopliteal artery (FPA) which are currently not available. Fresh human FPAs from n = 104 tissue donors 14-80 years old were tested using planar biaxial extension to capture elastic and damage characteristics. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.053DOI Listing
March 2019
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Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration.

Acta Biomater 2019 Mar 27. Epub 2019 Mar 27.

Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA. Electronic address:

The design and development of bioactive materials that are inherently conducive for osteointegration and bone regeneration with tunable mechanical properties and degradation remains a challenge. Herein, we report the development of a new class of citrate-based materials with glycerophosphate salts, β-glycerophosphate disodium (β-GP-Na) and glycerophosphate calcium (GP-Ca), incorporated through a simple and convenient one-pot condensation reaction, which might address the above challenge in the search of suitable orthopedic biomaterials. Tensile strength of the resultant poly (octamethylene citrate glycerophosphate), POC-βGP-Na and POC-GP-Ca, was as high as 28. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.050DOI Listing
March 2019
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High-speed X-ray visualization of dynamic crack initiation and propagation in bone.

Acta Biomater 2019 Mar 26. Epub 2019 Mar 26.

School of Aeronautics and Astronautics, Purdue University, 701 West Stadium Avenue, West Lafayette, IN 47907, USA; School of Materials Engineering, Purdue University, 701 West Stadium Avenue, West Lafayette, IN 47907, USA.

The initiation and propagation of physiological cracks in porcine cortical and cancellous bone under high rate loading were visualized using high-speed synchrotron X-ray phase-contrast imaging (PCI) to characterize their fracture behaviors under dynamic loading conditions. A modified Kolsky compression bar was used to apply dynamic three-point flexural loadings on notched specimens and images of the fracture processes were recorded using a synchronized high-speed synchrotron X-ray imaging set-up. Three-dimensional synchrotron X-ray tomography was conducted to examine the initial microstructure of the bone before high-rate experiments. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.045DOI Listing

A star copolymer consisting of a β-cyclodextrin core and poly(amidoamine) dendron arms for co-delivering nitric oxide and triclosan for combined antibacterial effect.

Acta Biomater 2019 Mar 27. Epub 2019 Mar 27.

The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510632, China; School of Stomatology of Jinan University, Jinan University, Guangzhou 510632, China. Electronic address:

To co-deliver the antibacterial agents of nitric oxide (NO) and triclosan (TCA) for a combined antimicrobial effect, a star copolymer consisting of a β-cyclodextrin core and poly(amidoamine) dendron arms (β-CD-PAMAM) was synthesized, and TCA was encapsulated into the hydrophobic core of β-CD and NO was conjugated with the PAMAM arms. The obtained β-CD-PAMAM/TCA/NONOate was expected to combine the biofilm dispersal effect of NO with the antibacterial effect of both NO and TCA. We demonstrated that β-CD-PAMAM/TCA/NONOate could release TCA and NO simultaneously and showed an excellent antibacterial effect on both gram-negative bacteria (Escherichia coli) and gram-positive bacteria (Staphylococcus aureus). Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.051DOI Listing
March 2019
1 Read