5,850 results match your criteria Acta biomaterialia[Journal]


Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

WPI Research Initiative for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan; Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. Electronic address:

The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold nanoparticles (GNPs) through hitherto unknown mechanisms. Here, we identified an essential role of membrane rafts in the drastic activity switching of EGF-GNPs through the following intracellular signaling. 1) In contrast to the rapid diffusion of activated EGF receptor after the soluble EGF stimulation, the receptor is confined within membrane rafts upon binding to the EGF-GNPs. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.026DOI Listing
February 2019

A transferrin receptor-binding mucoadhesive elastin-like recombinamer: in vitro and in vivo characterization.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

BIOFORGE (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, University of Valladolid, Paseo de Belén 19, 47011, Spain. Electronic address:

The development of mucoadhesive materials is of great interest and is also a major challenge. Being adsorption sites, mucosae are suitable targets for drug delivery, but as defensive barriers they are complex biological surfaces to interact with, mainly due to their protective mucus layer. As such, first- and second-generation mucoadhesives focused on material-mucus interactions, whereas the third generation of mucoadhesives introduced structural motifs that are able to interact with the cells beneath the mucus layer. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.027DOI Listing
February 2019

Toward Tissue-engineering of Nasal Cartilages.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA, 92697-2715, USA. Electronic address:

Nasal cartilage pathologies are common; for example, up to 80% of people are afflicted by deviated nasal septum conditions. Because cartilage provides the supportive framework of the nose, afflicted patients suffer low quality of life. To correct pathologies, graft cartilage is often required. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.025DOI Listing
February 2019

Effect of magnesium-degradation products and hypoxia on the angiogenesis of human umbilical vein endothelial cells.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

Institute of Materials Research, Division for Metallic Biomaterials, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany. Electronic address:

Biodegradable magnesium (Mg) metals have been applied in orthopaedic and stent applications due to their biodegradability, bioabsorbability and adaptability to tissue regeneration. However, further investigations are still needed to understand how angiogenesis will respond to high concentrations of Mg and oxygen content differences, which are vital to vascular remodelling and bone fracture regeneration or tissue healing. Human primary endothelial cells were exposed to various concentrations (2 to 8 mM) of extracellular Mg degradation products under either hypoxia or normoxia. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.018DOI Listing
February 2019

Fibronectin fiber creep under constant force loading.

Acta Biomater 2019 Feb 16. Epub 2019 Feb 16.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States. Electronic address:

Viscoelasticity is a fundamental property of virtually all biological materials, and proteinaceous, fibrous materials that constitute the extracellular matrix (ECM) are no exception. Viscoelasticity may be particularly important in the ECM since cells can apply mechanical stress resulting from cell contractility over very long periods of time. However, measurements of ECM fiber response to long-term constant force loading are scarce, despite the increasing recognition that mechanical strain regulates the biological function of some ECM fibers. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.022DOI Listing
February 2019

Engineering Human Ventricular Heart Tissue Based on Macroporous Iron Oxide Scaffolds.

Acta Biomater 2019 Feb 16. Epub 2019 Feb 16.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Key Laboratory of Clinical Geriatric Medicine, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Birth Defect, Children's Hospital of Fudan University, Shanghai, 201102 China. Electronic address:

Myocardial infarction (MI) is a primary cardiovascular disease threatening human health and quality of life worldwide. The development of engineered heart tissues (EHTs) as a transplantable artificial myocardium provides a promising therapy for MI. Since most MIs occur at the ventricle, engineering ventricular-specific myocardium is therefore more desirable for future applications. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.024DOI Listing
February 2019

A 3D study of the relationship between leaf vein structure and mechanical function.

Acta Biomater 2019 Feb 16. Epub 2019 Feb 16.

Department of Structural Biology, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel. Electronic address:

We investigate the structures and mechanical properties of leaf midribs of Ficus microcarpa and Prunus dulcis, which deposit calcium oxalate crystals, and of Olea europaea midribs which contain no mineral deposits, but do contain lignified fibers. The midrib mechanical performance contributes to the leaf's ability to maintain a flat conformation for light harvesting and to efficiently reconfigure to reduce wind drag. We use a novel approach involving 3D visualization of the vein structure during mechanical load. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.023DOI Listing
February 2019

Effects of silver diammine fluoride/potassium iodide on artificial root caries lesions with adjunctive application of proanthocyanidin.

Acta Biomater 2019 Feb 15. Epub 2019 Feb 15.

Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia. Electronic address:

Treatment of carious root surfaces remains challenging due to the complex pathological processes and difficulty in restoring the original structure of root dentine. Current treatments targeting the de-/re-mineralisation processes are not entirely satisfactory in terms of the protection of the dentinal organic matrix and the highly organised structure of dentine. In this in vitro study, a cross-linking agent - proanthocyanidin (PA) was used in conjunction with a fluoride-based treatment - silver diammine fluoride/potassium iodide (SDF/KI) to putatively stabilise the organic dentinal framework as well as strengthen the collagen-mineral phase interaction. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.020DOI Listing
February 2019
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Laser-Based 3D Bioprinting for Spatial and Size Control of Tumor Spheroids and Embryoid Bodies.

Acta Biomater 2019 Feb 15. Epub 2019 Feb 15.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 Eighth St., Troy, NY 12180, USA. Electronic address:

3D multicellular aggregates, and more advanced organotypic systems, have become central tools in recent years to study a wide variety of complex biological processes. Most notably, these model systems have become mainstream within oncology (multicellular tumor spheroids) and regenerative medicine (embryoid bodies) research. However, the biological behavior of these in vitro tissue surrogates is extremely sensitive to their aggregate size and geometry. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.014DOI Listing
February 2019
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Angiogenesis involvement by octacalcium phosphate-gelatin composite-driven bone regeneration in rat calvaria critical-sized defect.

Acta Biomater 2019 Feb 15. Epub 2019 Feb 15.

Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan. Electronic address:

Effect of octacalcium phosphate/gelatin composite (OCP/Gel) on angiogenesis was studied by its implantation in rat calvaria critical-sized defect in relation to bone regeneration for 2 and 4 weeks. The implantation of OCP/Gel disks was analyzed by radiomorphometry using a radiopaque material perfusion (Microfil®) method and histomorphometry by hematoxylin and eosin (HE)-staining before and after the decalcification. Effect of the OCP dose in the range up to 4 mg per well on the capillary-like tube formation by human umbilical vein endothelial cells (HUVECs) was also examined in a transwell cell culture. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.021DOI Listing
February 2019

A Strong, Tough, and Osteoconductive Hydroxyapatite Mineralized Polyacrylamide/Dextran Hydrogel for Bone Tissue Regeneration.

Acta Biomater 2019 Feb 14. Epub 2019 Feb 14.

Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address:

The design of hydrogels with adequate mechanical properties and excellent bioactivity, osteoconductivity, and capacity for osseointegration is essential to bone repair and regeneration. However, it is challenging to integrate all these properties into one bone scaffold. Herein, we developed a strong, tough, osteoconductive hydrogel by a facile one-step micellar copolymerization of acrylamide and urethacrylate dextran (Dex-U), followed by the in situ mineralization of hydroxyapatite (HAp) nanocrystals. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.019DOI Listing
February 2019

Oxidized alginate hydrogels with the GHK peptide enhance cord blood mesenchymal stem cell osteogenesis: a paradigm for metabolomics-based evaluation of biomaterial design.

Acta Biomater 2019 Feb 14. Epub 2019 Feb 14.

Biological Systems Engineering Laboratory, Department of Chemical Engineering & Chemical Technology, Imperial College London, London, UK. Electronic address:

Oxidized alginate hydrogels are appealing alternatives to natural alginate due to their favourable biodegradability profiles and capacity to self-crosslink with amine containing molecules facilitating functionalization with extracellular matrix cues, which enable modulation of stem cell fate, achieve highly viable 3-D cultures, and promote cell growth. Stem cell metabolism is at the core of cellular fate (proliferation, differentiation, death) and metabolomics provides global metabolic signatures representative of cellular status, being able to accurately identify the quality of stem cell differentiation. Herein, umbilical cord blood mesenchymal stem cells (UCB MSCs) were encapsulated in novel oxidized alginate hydrogels functionalized with the glycine-histidine-lysine (GHK) peptide and differentiated towards the osteoblastic lineage. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.017DOI Listing
February 2019

Advances in Immunotherapy Delivery from Implantable and Injectable Biomaterials.

Acta Biomater 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, Department of Bioengineering, Rice University, Houston, TX 77005, United states. Electronic address:

Macroscale biomaterials, such as preformed implantable scaffolds and injectable soft materials, possess powerful synergies with anti-cancer immunotherapies. Immunotherapies on their own typically have poor delivery properties, and often require repeated high-dose injections that result in serious off-tumor effects and/or limited efficacy. Rationally designed biomaterials allow for discrete localization and controlled release of immunotherapeutic agents, and have been shown in a large number of applications to improve outcomes in the treatment of cancers via immunotherapy. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.016DOI Listing
February 2019

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness.

Acta Biomater 2019 Feb 13. Epub 2019 Feb 13.

Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China; Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan, PR China; Center for Information in Biology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, PR China. Electronic address:

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM stiffness in cancer is well known. However, the biomechanical behavior of tumor cells and the underlying mechanotransduction pathways remain unclear. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.015DOI Listing
February 2019
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Different effects of single protein vs. protein mixtures on magnesium degradation under cell culture conditions.

Acta Biomater 2019 Feb 13. Epub 2019 Feb 13.

Helmholtz-Zentrum Geesthacht, Institute of Material Research, Max-Planck-Str. 1, 21502 Geesthacht, Germany. Electronic address:

Bovine serum albumin (BSA) or fetal bovine serum (FBS), as the protein component, is usually added into solution to study the influence of proteins on Mg degradation. However, the specific character of proteins used and the interaction between organic molecules in FBS do not draw enough attention. This study investigated the influence of BSA, fibrinogen (Fib) and FBS on Mg degradation in Hanks' balanced salt solution without (HBSS) or with calcium (HBSSCa) and Dulbecco's modified eagle medium Glutamax-I (DMEM). Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.013DOI Listing
February 2019
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Microgels: Modular, Tunable Constructs for Tissue Regeneration.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

Chemical & Biological Engineering, Colorado School of Mines, Golden, CO, United States. Electronic address:

Biopolymer microgels are emerging as a versatile tool for aiding in the regeneration of damaged tissues due to their biocompatible nature, tunable microporous structure, ability to encapsulate bioactive factors, and tailorable properties such as stiffness and composition. These properties of microgels, along with their injectability, have allowed for their utilization in a multitude of different tissue engineering applications. Controlled release of growth factors, antibodies, and other bioactive factors from microgels have demonstrated their capabilities as transporters for essential bioactive molecules necessary for guiding tissue reconstruction. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.011DOI Listing
February 2019
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Augmenting the synergies of chemotherapy and immunotherapy through drug delivery.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, Georgia, 30332, United States; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, Georgia, 30332, United States; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr NW, Atlanta, Georgia, 30332, United States; Emory University, 201 Dowman Drive, Atlanta, Georgia, 30322, United States; Emory University School of Medicine, 1365-C Clifton Road NE, Winship Cancer Institute, Atlanta, Georgia, 30322, United States. Electronic address:

Despite the recent approvals of multiple cancer immunotherapies, low tumor immunogenicity and immunosuppressive tumor microenvironments prevent a large portion of patients from responding to these treatment modalities. Given the immunomodulatory and adjuvant effects of conventional chemotherapy as well as its widespread clinical use, the use of chemotherapy in combination with immunotherapy (so-called chemoimmunotherapy) is an attractive approach to potentiate the effects of immunotherapy in more patient populations. However, due to the limited extent of tumor accumulation, poorly controlled interactions with the immune system, and effects on systemic healthy tissues by chemotherapeutic drugs, the incorporation of anti-cancer agents into biomaterial-based structures, such as nanocarriers, is highly attractive to improve the safety and efficacy of chemoimmunotherapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193011
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http://dx.doi.org/10.1016/j.actbio.2019.02.012DOI Listing
February 2019
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In Vitro Testing of a First-In-Class Tri-alkylnorspermidine-biaryl Antibiotic in an Anti-biofilm Silicone Coating.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

George E. Wahlen Department of Veterans Affairs, Salt Lake City, Utah, United States; Department of Orthopaedics, University of Utah, Salt Lake City, Utah, United States; Curza Global, LLC, Salt Lake City, Utah, United States; Department of Pathology, University of Utah, Salt Lake City, Utah, United States; Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address:

Biofilm-related infection is among the worst complication to prosthetic joint replacement procedures; once established on the implant surface, biofilms show strong recalcitrance to clinical antibiotic therapy, frequently requiring costly revision procedures and prolonged systemic antibiotics for their removal. A well-designed active release coating might assist host immunity in clearing bacterial contaminants within the narrow perioperative window and ultimately prevent microbial colonization of the joint prosthesis. A first-in-class compound (CZ-01127) was tested as the active release agent in a silicone (Si) coating using an in vitro dynamic flow model of surgical site contamination and compared with analogous coatings containing clinical gold-standard antibiotics vancomycin and gentamicin; the CZ-01127 coating outperformed both vancomycin and gentamicin coatings and was the only to decrease the methicillin-resistant Staphylococcus aureus (MRSA) inocula below detectable limits for the first 3 days. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.010DOI Listing
February 2019
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Core-matched nanoassemblies for targeted co-delivery of chemotherapy and photosensitizer to treat drug-resistant cancer.

Acta Biomater 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacy, Shanghai Pudong Hospital, Fudan University, 2800 Gongwei Road, Shanghai 201399, PR China; Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China. Electronic address:

Emergence of drug resistance in tumors causes therapeutic failure or tumor relapse. Combination of chemotherapy and photodynamic therapy holds significant promise to treat drug-resistant tumors. However, stubborn hydrophobicity of photosensitizer (PS), low encapsulation efficiency and leaking problem of PS in organic carrier, and disparate physicochemical properties of PS and chemotherapeutics make the combination unachievable. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.009DOI Listing
February 2019
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Hydrophobic and antimicrobial dentin: A peptide-based 2-tier protective system for dental resin composite restorations.

Acta Biomater 2019 Feb 10. Epub 2019 Feb 10.

MDRCBB-Minnesota Dental Research Center for Biomaterials and Biomechanics, Department of Restorative Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Dental caries, i.e., tooth decay mediated by bacterial activity, is the most widespread chronic disease worldwide. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.007DOI Listing
February 2019
2 Reads

Porous Se@SiO nanosphere-coated catheter accelerates prostatic urethra wound healing by modulating macrophage polarization through reactive oxygen species-NF-κB pathway inhibition.

Acta Biomater 2019 Feb 10. Epub 2019 Feb 10.

Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address:

Benign prostatic hyperplasia (BPH) patients experience complications after surgery. We studied oxidative stress scavenging by porous Se@SiO nanospheres in prostatic urethra wound healing after transurethral resection of the prostate (TURP). Beagle dogs were randomly distributed into two groups after establishing TURP models. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.006DOI Listing
February 2019
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Rate-dependency of the mechanical behaviour of semilunar heart valves under biaxial deformation.

Acta Biomater 2019 Feb 9. Epub 2019 Feb 9.

Cardiovascular Engineering Research Laboratory (CERL), School of Mechanical and Design Engineering, University of Portsmouth, Anglesea Road, Portsmouth PO1 3DJ, United Kingdom.

This paper presents an experimental investigation and evidence of rate-dependency in the planar mechanical behaviour of semilunar heart valves. Samples of porcine aortic and pulmonary valves were subjected to biaxial deformations across 1000-fold stretch rate, ranging from λ̇=0.001 to 1s. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.008DOI Listing
February 2019

Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: Experimental studies in vitro and in rats.

Acta Biomater 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory of Military Stomatology Department of Periodontology, School of Stomatology, Fourth Military Medical University, Xi'an, P.R. China; National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, Xi'an, P.R. China; Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Periodontology, School of Stomatology, Fourth Military Medical University, Xi'an, P.R. China. Electronic address:

Recently, we found that although high-stiffness matrices stimulated osteogenic differentiation of bone marrow-derived stromal cells (BMSCs), the macrophages (Mφs) in high-stiffness transglutaminase crosslinked gelatins (TG-gels) tended to undergo M1 polarization and hence compromised cell osteogenesis. In this study, we hypothesized that the copresentation of interleukin (IL)-4 and stromal cell-derived factor (SDF)-1α in high-stiffness TG-gels may enhance periodontal regeneration by modulating Mφ polarization and promoting endogenous stem cell recruitment. We found that Mφs were more likely to polarize toward an immunomodulatory M2 state in the presence of IL-4 and hence positively influence the osteogenic differentiation of BMSCs when these cells coexisted in either indirect or direct co-culture systems. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193010
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http://dx.doi.org/10.1016/j.actbio.2019.02.004DOI Listing
February 2019
10 Reads

Endoplasmic reticulum-targeted phototherapy using one-step synthesized trace metal-doped carbon-dominated nanoparticles: Laser-triggered nucleolar delivery and increased tumor accumulation.

Acta Biomater 2019 Feb 5. Epub 2019 Feb 5.

State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing 210096, Jiangsu, PR China. Electronic address:

Lysosomal entrapment and liver accumulation are the two main obstacles faced by many anticancer drugs for achieving satisfactory therapeutic outcomes. Here, we develop a facile one-step hydrothermal synthetic route to prepare trace metal (M)-, N-, and O-doped carbon-dominated nanoparticles (termed as MNOCNPs, M = Ni, Pd, or Cu, metal content: < 0.1 mol %) with exceptional photothermal properties (e. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.005DOI Listing
February 2019
2 Reads

The role of tissue remodeling in mechanics and pathogenesis of abdominal aortic aneurysms.

Acta Biomater 2019 Feb 5. Epub 2019 Feb 5.

Institute of Biomechanics, Graz University of Technology, Stremayrgasse 16/2, 8010 Graz, Austria; Norwegian University of Science and Technology (NTNU), Faculty of Engineering Science and Technology, 7491 Trondheim, Norway. Electronic address:

Arterial walls can be regarded as composite materials consisting of collagen fibers embedded in an elastic matrix and smooth muscle cells. Remodeling of the structural proteins has been shown to play a significant role in the mechanical behavior of walls during pathogenesis of abdominal aortic aneurysms (AAA). In this study, we systematically studied the change in the microstructure, histology and mechanics to link them to AAA disease progression. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.070DOI Listing
February 2019
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Non-invasive in vivo quantification of human skin tension lines.

Acta Biomater 2019 Feb 5. Epub 2019 Feb 5.

Department of Biomedical Engineering, Binghamton University, NY 13902, USA. Electronic address:

Human skin is a composite tissue that exhibits anisotropic mechanical properties. This anisotropy arises primarily from the alignment of collagen and elastin fibers in the dermis, which causes the skin to exhibit greater tension in one direction, making it appear stiffer. A diverse number of skin tension guidelines have been developed to assist surgeons in making incisions that produce the least conspicuous scars. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.003DOI Listing
February 2019

Engineering of gradient osteochondral tissue: From nature to lab.

Acta Biomater 2019 Feb 2. Epub 2019 Feb 2.

Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran. Electronic address:

The osteochondral tissue is an interface between two distinct tissues: articular cartilage and bone. These two tissues are significantly diverse with regard to their chemical compositions, mechanical properties, structure, electrical properties, and the amount of nutrient and oxygen consumption. Thus, transition from the surface of the articular cartilage to the subchondral bone needs to face several smooth gradients. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.071DOI Listing
February 2019
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Thin Peptide Hydrogel Membranes Suitable as Scaffolds for Engineering Layered Biostructures.

Acta Biomater 2019 Feb 2. Epub 2019 Feb 2.

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore; Laboratory for Nanomedicine, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. Electronic address:

A short tetramer peptide, Ac-IVKC, spontaneously formed a hydrogel in water. Disulfide bonds were introduced via hydrogen peroxide (HO)-assisted oxidation, resulting in (Ac-IVKC) dimers. The extent of disulfide bond formation and gel stiffness increased with the amount of HO used and 100% dimerization was achieved with 0. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.001DOI Listing
February 2019
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Modifying decellularized aortic valve scaffolds with stromal cell-derived factor-1α loaded proteolytically degradable hydrogel for recellularization and remodeling.

Acta Biomater 2019 Feb 2. Epub 2019 Feb 2.

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:

Decellularized matrix is of great interest as a scaffold for the tissue engineering heart valves due to its naturally three-dimensional structure and bioactive composition. A primary challenge of tissue engineered heart valves based on decellularized matrix is to grow a physiologically appropriate cell population within the leaflet tissue. In this study, a composite scaffold was fabricated by the combination of a porous matrix metalloproteinase (MMP) degradable poly (ethylene glycol) (PEG) hydrogel that were loaded with stromal cell-derived factor-1α (SDF-1α) and a mechanically supportive decellularized porcine aortic valve. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.002DOI Listing
February 2019

Ureter tissue engineering with vessel extracellular matrix and differentiated urine-derived stem cells.

Acta Biomater 2019 Feb 1. Epub 2019 Feb 1.

Department of Biochemistry, Jining Medical University, Jining, Shandong 272067, PR China; Collaborative Innovation Center, Jining Medical University, Jining, Shandong 272067, PR China. Electronic address:

Objective: To assess the possibility of ureter tissue engineering using vessel extracellular matrix (VECM) and differentiated urine-derived stem cells (USCs) in a rabbit model.

Methods: VECM was prepared by a modified technique. USCs were isolated from human urine samples and cultured with an induction medium for the differentiation of the cells into urothelium and smooth muscle phenotypes. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.072DOI Listing
February 2019

Structure-function relationships of fetal ovine articular cartilage.

Acta Biomater 2019 Feb 1. Epub 2019 Feb 1.

Department of Biomedical Engineering, University of California Irvine, 3120 Natural Sciences II, Irvine, CA 92697-2715, USA. Electronic address:

It is crucial that the properties of engineered neocartilage match healthy native cartilage to promote the functional restoration of damaged cartilage. To accurately assess the quality of neocartilage and the degree of biomimicry achieved, its properties must be evaluated against native cartilage and tissue from which the cells for neocartilage formation were sourced. Fetal ovine cartilage is a promising and translationally relevant cell source with which to engineer neocartilage, yet, it is largely non-characterized. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.073DOI Listing
February 2019
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Comment on "Tuning the bioactivity of bone morphogenetic protein-2 with surface immobilization strategies" by Chen et al.

Acta Biomater 2019 Feb 1. Epub 2019 Feb 1.

Max Planck Institute for Medical Research, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.actbio.2019.01.068DOI Listing
February 2019

Optimized liposomes with transactivator of transcription peptide and anti-apoptotic drugs to target hippocampal neurons and prevent tau-hyperphosphorylated neurodegeneration.

Acta Biomater 2019 Feb 1. Epub 2019 Feb 1.

Department of Chemical Engineering, National Chung Cheng University, Chia-Yi 62102, Taiwan, Republic of China.

Liposomes (lip) carrying pharmaceuticals have shown promise in their ability to advance the therapy for neurodegenerative diseases. However, the low nerve-targeting capacity and poor penetration rate of lip through the blood-brain barrier (BBB) are major hurdles to achieving successful treatment. Herein, we developed lip incorporating cardiolipin (CL) and phosphatidic acid (PA) to promote their capability against hyperphosphorylation of tau protein, and a transactivator of transcription (TAT) peptide to permeate the BBB for delivering nerve growth factor (NGF), rosmarinic acid (RA), curcumin (CURC) and quercetin (QU). Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.065DOI Listing
February 2019

Response to Letter to Editor "Comment on 'Tuning the bioactivity of bone morphogenetic protein-2 with surface immobilization strategies' by Chen et al."

Authors:
Jing Wang

Acta Biomater 2019 Feb 1. Epub 2019 Feb 1.

Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China; Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2019.01.069DOI Listing
February 2019

Highly-branched poly(N-isopropyl acrylamide) functionalised with pendant Nile red and chain end vancomycin for the detection of Gram-positive bacteria.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

Polymer and Biomaterials Chemistry Laboratories, School of Chemistry and Biosciences, University of Bradford, Bradford BD7 1DP, UK. Electronic address:

This study shows how highly branched poly(N-isopropyl acrylamide) (HB-PNIPAM) with a chain pendant solvatochromic dye (Nile red) could provide a fluorescence signal, as end groups bind to bacteria and chain segments become desolvated, indicating the presence of bacteria. Vancomycin was attached to chain ends of HB-PNIPAM or as pendant groups on linear polymers each containing Nile red. Location of the dye was varied between placement in the core of the branched polymer coil or the outer domains. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.066DOI Listing
January 2019

Brain and bone cancer targeting by a ferrofluid composed of superparamagnetic iron-oxide/silica/carbon nanoparticles (earthicles).

Acta Biomater 2019 Feb 1. Epub 2019 Feb 1.

Advanced Materials and Nanobiotechnology Laboratory, Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University, Irvine, CA 92618-1908, USA; Advanced Materials and Nanobiotechnology Laboratory, Department of Bioengineering, University of Illinois, Chicago, IL 60607-7052, USA. Electronic address:

Despite the advances in molecularly targeted therapies, delivery across the blood-brain barrier (BBB) and the targeting of brain tumors remains a challenge. Like brain, bone is a common site of metastasis and requires therapies capable of discerning the tumor from its healthy cellular milieu. To tackle these challenges, we made a variation on the previously proposed concept of the earthicle and fabricated an aqueous, surfactant-free ferrofluid containing superparamagnetic iron oxide nanoparticles (SPIONs) coated with silicate mesolayers and carbon shells, having 13 nm in size on average. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193008
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http://dx.doi.org/10.1016/j.actbio.2019.01.064DOI Listing
February 2019
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Natural hydrogel in American lobster: A soft armor with high toughness and strength.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

Homarus americanus, known as American lobster, is fully covered by its exoskeleton composed of rigid cuticles and soft membranes. These soft membranes are mainly located at the joints and abdomen to connect the rigid cuticles and greatly contribute to the agility of the lobster in swimming and preying. Herein, we show that the soft membrane from American lobster is a natural hydrogel (90% water) with exceptionally high toughness (up to 24. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193008
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http://dx.doi.org/10.1016/j.actbio.2019.01.067DOI Listing
January 2019
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6.025 Impact Factor

Bioactive Factors for Cartilage Repair and Regeneration: Improving Delivery, Retention, and Activity.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104., United States; Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, 19104., United States; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, United States. Electronic address:

Articular cartilage is a remarkable tissue whose sophisticated composition and architecture allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the capacity to self-repair, and injuries often progress to joint wide osteoarthritis (OA) resulting in debilitating pain and loss of mobility. Current palliative and surgical management provides short-term symptom relief, but almost always progresses to further deterioration in the long term. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.061DOI Listing
January 2019

Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA; Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA. Electronic address:

Although bone tissues possess an intrinsic capacity for repair, there are cases where bone healing is either impaired or insufficient, such as fracture non-union, osteoporosis, osteomyelitis, and cancers. In these cases, treatments like surgical interventions are used, either alone or in combination with bioactive agents, to promote tissue repair and manage associated clinical complications. Improving the efficacy of bioactive agents often requires carriers, with biomaterials being a pivotal player. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.060DOI Listing
January 2019
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Polymer scaffolds facilitate spinal cord injury repair.

Acta Biomater 2019 Jan 30. Epub 2019 Jan 30.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China; Jilin Biomedical Polymers Engineering Laboratory, 5625 Renmin Street, Changchun 130022, People's Republic of China.

During the past decades, improving patient neurological recovery following spinal cord injury (SCI) has remained a challenge. An effective treatment for SCI would not only reduce fractured elements and isolate developing local glial scars to promote axonal regeneration but also ameliorate secondary effects including inflammation, apoptosis, and necrosis. Three-dimensional (3D) scaffolds provide a platform in which these mechanisms can be addressed in a controlled manner. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.056DOI Listing
January 2019
1 Read
6.025 Impact Factor

Decellularized neonatal cardiac extracellular matrix prevents widespread ventricular remodeling in adult mammals after myocardial infarction.

Acta Biomater 2019 Jan 30. Epub 2019 Jan 30.

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh and UPMC, Pittsburgh, PA 15260, USA. Electronic address:

Heart disease remains a leading killer in western society and irreversibly impacts the lives of millions of patients annually. While adult mammals do not possess the ability to regenerate functional cardiac tissue, neonatal mammals are capable of robust cardiomyocyte proliferation and regeneration within a week of birth. Given this change in regenerative function through development, the extracellular matrix (ECM) from adult tissues may not be conducive to promoting cardiac regeneration, although conventional ECM therapies rely exclusively on adult-derived tissues. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.062DOI Listing
January 2019
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Gelatin-based micro-hydrogel carrying genetically engineered human endothelial cells for neovascularization.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea; Institute of Engineering Research, Seoul National University, Seoul 08826, Republic of Korea; Bio-MAX/N-Bio Institute, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Cell delivery systems based on micro-hydrogels may facilitate the long-term survival of cells upon transplantation. Micro-hydrogels may effectively support cell proliferation, attachment, and migration in ischemic environments. In this study, we report the fabrication of a gelatin methacrylate (GelMA)-based micro-hydrogel for efficient in vivo delivery of genetically engineered endothelial cells. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.057DOI Listing
January 2019
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Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness.

Acta Biomater 2019 Jan 30. Epub 2019 Jan 30.

Centre for Stem Cells and Regenerative Medicine, King's College London, 28th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom. Electronic address:

In human skin the junction between epidermis and dermis undulates, the width and depth of the undulations varying with age and disease. When primary human epidermal keratinocytes are seeded on collagen-coated polydimethylsiloxane (PDMS) elastomer substrates that mimic the epidermal-dermal interface, the stem cells become patterned by 24 h, resembling their organisation in living skin. We found that cell density and nuclear height were higher at the base than the tips of the PDMS features. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.063DOI Listing
January 2019

In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

Curza Global, LLC, Salt Lake City, UT, United States; Synthetic and Medicinal Chemistry Core, University of Utah, Salt Lake City, UT, United States; Department of Chemistry, University of Utah, Salt Lake City, UT, United States.

Prosthetic joint infection (PJI) is a well-known and persisting problem. Active release coatings have promise to provide early protection to an implant by eradicating small colony biofilm contaminants or planktonic bacteria that can form biofilm. Traditional antibiotics can be limited as active release agents in that they have limited effect against biofilms and develop resistance at sub-lethal concentrations. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.055DOI Listing
January 2019

Micropatterning of a 2-methacryloyloxyethyl phosphorylcholine polymer surface by hydrogenated amorphous carbon thin films for endothelialization and antithrombogenicity.

Acta Biomater 2019 Jan 31. Epub 2019 Jan 31.

Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. Electronic address:

The existing first-generation drug-eluting stent (DES) has caused late and very late stent thrombosis related to incomplete stent endothelialization. Hence, biomaterials that possess sufficient anti-thrombogenicity and endothelialization with the controlled drug release system have been highly required. In this work, we have developed a newly designed drug-release platform composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, a non-thrombogenic polymer, and micropatterned hydrogenated amorphous carbon (a-C:H), a cell-compatible thin film. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.059DOI Listing
January 2019

Cross-linked cellulose nanocrystal aerogels as viable bone tissue scaffolds.

Acta Biomater 2019 Jan 30. Epub 2019 Jan 30.

Department of Material Science and Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L7, Canada; School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L7, Canada. Electronic address:

Chemically cross-linked cellulose nanocrystal (CNC) aerogels possess many properties beneficial for bone tissue scaffolding applications. CNCs were extracted using sulfuric acid or phosphoric acid, to produce CNCs with sulfate and phosphate half-ester surface groups, respectively. Hydrazone cross-linked aerogels fabricated from the two types of CNCs were investigated using scanning electron microscopy, X-ray micro-computed tomography, X-ray photoelectron spectroscopy, nitrogen sorption isotherms, and compression testing. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.049DOI Listing
January 2019

Corrigendum to "Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants" [Acta Biomater. 69 (2018) 120-130].

Acta Biomater 2019 Jan 29. Epub 2019 Jan 29.

Dept. of Clinical and Experimental Medicine, Linköping University, S-58185 Linköping, Sweden; Maisonneuve-Rosemont Hospital Research Centre and Dept. of Ophthalmology, University of Montreal, Montreal, QC H1T 4B3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2019.01.046DOI Listing
January 2019

Self-mineralizing Ca-enriched methacrylated gellan gum beads for bone tissue engineering.

Acta Biomater 2019 Jan 29. Epub 2019 Jan 29.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, AvePark, 4805-017 Barco, Guimarães, Portugal. Electronic address:

In this study, methacrylated gellan-gum (GG-MA) heteropolysaccharide is proposed as a hydrogel for drug delivery and bone tissue engineering applications. Calcium-enriched beads obtained from the crosslinking of 1% (w/v) GG-MA solutions with 0.1 MCaCl were investigated, considering their intrinsic capacity to promote self-mineralization by ion binding and deposition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193007
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http://dx.doi.org/10.1016/j.actbio.2019.01.053DOI Listing
January 2019
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Biodegradable Pickering emulsions of Lipiodol for liver trans-arterial chemo-embolization.

Acta Biomater 2019 Jan 30. Epub 2019 Jan 30.

Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 92296 Châtenay-Malabry, France. Electronic address:

Water-in-oil (W/O) Lipiodol emulsions remain the preferable choice for local delivery of chemotherapy in the treatment of hepatocellular carcinoma. However, their low stability severely hampers their efficiency. Here, remarkably stable W/O Lipiodol emulsion stabilized by biodegradable particles was developed thanks to Pickering technology. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.054DOI Listing
January 2019
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Incorporation of types I and III collagen in tunable hyaluronan hydrogels for vocal fold tissue engineering.

Acta Biomater 2019 Jan 30. Epub 2019 Jan 30.

Weldon School of Biomedical Engineering, Purdue University, United States; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, United States.

Vocal fold scarring is the fibrotic manifestation of a variety of voice disorders, and is difficult to treat. Tissue engineering therapies provide a potential strategy to regenerate the native tissue microenvironment in order to restore vocal fold functionality. However, major challenges remain in capturing the complexity of the native tissue and sustaining regeneration. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.058DOI Listing
January 2019