653,106 results match your criteria Acta bio-medica : Atenei Parmensis[Journal]


Central venous line-related thromboembolism is common in children with non-high risk acute lymphoblastic leukaemia.

Acta Paediatr 2019 Feb 20. Epub 2019 Feb 20.

Department of Paediatric Haematology and Oncology, Oslo University Hospital, Norway.

Children with acute lymphoblastic leukaemia face increased risks of thromboembolism, and major risk factors for this serious treatment-related toxicity are central venous lines, asparaginase and steroids. Central venous lines have become standard care in paediatric oncology, facilitating therapy and improving patients' quality of life. However, up to half of the children with acute lymphoblastic leukaemia will develop asymptomatic central venous line-related thromboembolism. Read More

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http://dx.doi.org/10.1111/apa.14757DOI Listing
February 2019

Social cognition in bipolar disorder: the role of sociodemographic, clinical and neurocognitive variables in emotional intelligence.

Acta Psychiatr Scand 2019 Feb 20. Epub 2019 Feb 20.

Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Objective: The main aims of this study were to examine the differences in the Emotional Intelligence (EI), the emotional domain of social cognition (SC), between euthymic patients with bipolar disorder (BD) and healthy controls (HC) and to evaluate the contribution of sociodemographic, clinical and neuropsychological variables to EI.

Methods: We recruited 202 patients with BD and 50 HC. EI was evaluated using the Mayer Salovey Caruso Emotional Intelligence Test (MSCEIT). Read More

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http://dx.doi.org/10.1111/acps.13014DOI Listing
February 2019

The role of laparoscopy in the propaedeutics of gynecological diagnosis1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000010. Epub 2019 Feb 14.

Associate Professor III, Department of Gynecology and Obstetrics, Botucatu Medical School, UNESP, Botucatu-SP, Brazil. Conception and design of the study, manuscript preparation.

Purpose: To evaluate agreement between pre- and post-laparoscopy gynecological diagnosis in order to demonstrate the rationality of this minimally invasive technique use in gynecological propaedeutics.

Methods: Retrospective chart review study conducted between March 2010 and October 2016 based on a convenience sample. 315 patients undergoing surgical laparoscopy at the Center of Gynecologic Endoscopy and Family Planning of Botucatu Medical School/UNESP. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000010DOI Listing
February 2019

Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000009. Epub 2019 Feb 14.

PhD, Full Professor, Department of Farmacology, UFC, Fortaleza-CE, Brazil. Manuscript writing, critical revision, final approval.

Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation.

Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). Read More

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http://dx.doi.org/10.1590/s0102-865020190010000009DOI Listing
February 2019

Patents on hospital medical and dental equipment (EMHO). Question and answer tool.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000008. Epub 2019 Feb 14.

PhD, Postgraduate Program in Technology and Management of Tissue Regeneration, Medical School, UNIFESP, Sao Paulo-SP, Brazil. Analysis and interpretation of data, statistics analysis, critical revision, final approval.

Purpose: To create a question and answer tool on patents on EMHO.

Methods: Was used the Thinking Design methodology divided into four phases: Discovery, Definition, Development and Delivery. Discovery Phase: Desk research was carried out in: SciELO, Pubmed, LILACS, Google and Google Scholar. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000008DOI Listing
February 2019

Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000007. Epub 2019 Feb 14.

Master, Department of Nephrology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China. Acquisition of data.

Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000007DOI Listing
February 2019

The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000006. Epub 2019 Feb 14.

MD, Department of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Guangxi Medical University, China. Analysis and interpretation of data, critical revision.

Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.

Methods: Human microvascular endothelial cells (HMVECs) cultured in the third and fifth generations were used. HMVECs were divided into normal group, thrombin group (T group), natrual hirudin group (H group), thrombin + natrual hirudin group (T + H group), AG490 group, thrombin + AG490 group (T + AG490 group), natrual hirudin + AG490 group (H + AG490 group), thrombin + natural hirudin + AG490 (T + H + AG490 group). Read More

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http://dx.doi.org/10.1590/s0102-865020190010000006DOI Listing
February 2019

The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000005. Epub 2019 Feb 14.

MD, Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Hubei, China. Critical revision.

Purpose: To investigate the role of PI3k/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion(I/R).

Methods: Male Sprague-Dawley rats were subjected to 45 min of ischemia by occluding the superior mesenteric artery and to 2h of reperfusion to establish the model of I/R. Twenty four rats were randomly divided into four groups: Sham, intestinal I/R (II/R), propofol (P), wortmannin (W). Read More

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http://dx.doi.org/10.1590/s0102-865020190010000005DOI Listing
February 2019

Metronidazole concentration in the bloodstream following its topical application, at different concentration levels, on experimental skin wounds during healing by secondary intention1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000004. Epub 2019 Feb 14.

Associate Professor, Department of Surgery, and Permanent Instructor, Postgraduate in Surgical Medicine, UFPR, Curitiba-PR, Brazil. Technical procedures.

Purpose: To characterize qualitatively and quantitatively the absorption of metronidazole solution, in greater concentrations and for longer periods, when applied topically to an experimental open skin wound model.

Methods: An open skin wound, 2 cm in diameter and total skin thickness was prepared, under anesthetic, in the dorsal region of 108 Wistar rats weighing between 300 and 350 grams. The animals were allocated to groups of 18 animals in accordance with the concentration of metronidazole in the solution to be applied daily to the wound. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000004DOI Listing
February 2019

LBP reduces theinflammatory injuryof kidney in septic rat and regulates the Keap1-Nrf2∕ARE signaling pathway1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000003. Epub 2019 Feb 14.

PhD, Department of Anesthesiology, Renmin Hospital of Wuhan University, China. Technical procedures, final approval.

Purpose: To investigate the influence of lycium barbarum polysaccharides (LBP), a functional derivative from lycium barbarum, on septic kidney injury.

Methods: The SD male rats were randomly divided into 8 groups. The concentration of IL-1β, IL-6, IL-8, TNF-α, NF-κB and ROS, in kidney cortex homogenates after 12 h treatments were determined by enzyme-linked immunosorbent assay and ROS test kit, respectively. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000003DOI Listing
February 2019

Bone callus formation is highly disrupted by dietary restriction in growing rats sustaining a femoral fracture1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000002. Epub 2019 Feb 14.

Full Professor, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, School of Medicine, USP, Ribeirao Preto-SP, Brazil. Design, intellectual and scientific content of the study; manuscript preparation, critical revision, final approval.

Purpose: To evaluate the effects of food restriction on fracture healing in growing rats.

Methods: Sixty-eight male Wistar rats were assigned to two groups: (1) Control and (2) Dietary restriction. After weaning the dietary restricted animals were fed ad libitum for 42 days with 50% of the standard chow ingested by the control group. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000002DOI Listing
February 2019

An experimental study of exenatide effects on renal injury in diabetic rats1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000001. Epub 2019 Feb 14.

Master, Second Department of Endocrinology, Tai'an Central Hospital, China. Design of the study, critical revision, final approval.

Purpose: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.

Methods: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000001DOI Listing
February 2019

Erratum: The effect of metyrosine on oxidative gastric damage induced by ischemia/reperfusion in rats. Biochemical and histopathological evaluation.

Authors:

Acta Cir Bras 2019 Feb 14;34(1):e20180308ERRATUM. Epub 2019 Feb 14.

[This corrects the article doi: 10.1590/s0102-865020180030000008]. Read More

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http://dx.doi.org/10.1590/s0102-865020180030000008ERRATUMDOI Listing
February 2019

Using vibrational ATR-FTIR spectroscopy with chemometrics to reveal faba CHO molecular spectral profile and CHO nutritional features in ruminant systems.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 16;214:269-276. Epub 2019 Feb 16.

College of Life Science and Engineering, Foshan University, China; The Branch Academy of Animal Science, Jilin Academy of Agricultural Science, China; Department of Animal Nutrition, Bangladesh Agricultural University, Bangladesh; Animal Nutrition Institute, Sichuan Agricultural University, China; Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, Canada. Electronic address:

The non-invasive spectroscopic technique is capable to detect the biomolecular structure spectral features that are associated with biological, nutritional and biodegradation functions. However, to date, no research has been reported on alteration of bioactive compounds/carbohydrate traits on physiochemical and structure spectral characteristics in faba pulse seeds. The objective of this study was to use non-invasive ATR-FTIR spectroscopy with uni- and multivariate analyses to reveal faba [VLF: VLF-1 = CDC snowdrop with low tannin and VLF-2 = FB9-4 with high tannin] CHO molecular spectral profile and CHO nutritional features in ruminant systems. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.011DOI Listing
February 2019

Determination of norfloxacin in urine and pharmaceutical samples using terbium doped zinc sulphide nanomaterials-sensitized fluorescence method.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 12;214:261-268. Epub 2019 Feb 12.

Department of Chemistry, Punjabi University, Patiala 147002, Punjab, India. Electronic address:

Highly crystalline polyethylene glycol (PEG) coated Tb doped ZnS nanoparticles have been synthesized and successfully used for norfloxacin sensing. The crystallographic and morphological analyses of PEG coated Tb doped ZnS nanoparticles were performed by X-ray diffraction and Transmission electron microscopy, respectively. The confirmation of Tb doping in ZnS host matrix was done by emission spectroscopy and energy dispersive X-ray spectroscopy. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.015DOI Listing
February 2019
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Comprehensive evaluation of wild Cordyceps cicadae from different geographical origins by TOPSIS method based on the macroscopic infrared spectroscopy (IR) fingerprint.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 13;214:252-260. Epub 2019 Feb 13.

College of Science, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Cordyceps cicadae is an entomogenous fungus that has been used as a valuable traditional Chinese herbal tonic, however, it can be difficult to discern the false from the genuine. In this study, the macroscopic IR fingerprint methods containing Fourier transform infrared spectroscopy (FT-IR) and second derivative infrared spectroscopy (SD-IR) were used to elucidate wild C. cicadae. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.031DOI Listing
February 2019

A comparative evaluation of the activities of thiol group and hydroxyl group in low-frequency vibrations using terahertz spectroscopy and DFT calculations.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 11;214:246-251. Epub 2019 Feb 11.

Department of Physics, School of Sciences, Nanchang University, Xuefu Avenue 999, Nanchang City 330031, China; Institute of Space Science and Technology, Nanchang University, Xuefu Avenue 999, Nanchang City 330031, China. Electronic address:

Low-frequency vibrations of biomolecules govern many biological processes like allostery of proteins, binding interaction and solvation. Revealing how involved are different groups of molecules in low-frequency vibrations is of significance to understand the behaviors of biomolecules. To compare the activities of hydroxyl group and thiol group in low-frequency vibrations, we conducted THz measurements and DFT calculations of l‑serine and l‑cysteine. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.018DOI Listing
February 2019

Locating the binding domains of lysozyme with ionic liquids in aqueous solution via spectroscopic studies.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 14;214:239-245. Epub 2019 Feb 14.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address:

The binding domains of lysozyme with ionic liquids (ILs, [Cmim]BF, [Cmim]Cl, [Cmim]Br and [dmim]I) in aqueous solution was investigated by studying molecular interactions using spectroscopic techniques. Ultraviolet spectroscopy (UV) showed that the addition of ILs increased the absorption peak intensity of lysozyme at 210 nm by enhancing peptide bond valence electron transition. It is also found that a weak interaction between ILs and lysozyme chromophore groups was generated by analyzing the changes of absorption peak intensity near 280 nm. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.032DOI Listing
February 2019

A highly sensitive fluorescent probe with different responses to Cu and Zn.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 5;214:233-238. Epub 2019 Feb 5.

College of Chemistry, Nanchang University, Nanchang 330031, China. Electronic address:

We report a highly sensitive fluorescent probe based on p-dimethylaminobenzoyl derivatives (probe L) for the detection of Cu and Zn. In this work, the probe L exhibited a fluorescent turn-on sensing model to Cu and Zn with a distinct fluorescent color change from colorless to green and yellow respectively. Probe L exhibited high selectivity as a fluorescent Cu/Zn probe with a limit of detection (LOD) of 45 nM/17 nM. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.007DOI Listing
February 2019

Food additive dye (quinoline yellow) promotes unfolding and aggregation of myoglobin: A spectroscopic and molecular docking analysis.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 13;214:216-226. Epub 2019 Feb 13.

Department of Chemistry, Collage of Science Princess Noura Bint Abdul Rahman University, Riyadh, Saudi Arabia. Electronic address:

Protein aggregation leads to vast conformational changes and plays a key role in the pathogenesis of various neurodegenerative diseases including Alzheimer's and Parkinson's. In the current piece of work, we have explored the interaction of quinoline yellow (QY) with myoglobin (Mb) at two different pH (3.5 and 7. Read More

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http://dx.doi.org/10.1016/j.saa.2019.01.090DOI Listing
February 2019

High pressure Raman scattering of DL‑isoleucine crystals and DFT calculations.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Jan 31;214:207-215. Epub 2019 Jan 31.

Departamento de Física, Universidade Federal do Ceará, C. P. 6030, CEP 60455-760 Fortaleza, CE, Brazil. Electronic address:

DL‑isoleucine single crystals were grown by the slow evaporation method at ambient temperature. Their vibrational properties were studied at ambient temperature as a function of pressure by Raman scattering. At ambient conditions the mode assignment was done in terms of the Potential Energy Distribution (PED) through density functional theory calculations. Read More

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http://dx.doi.org/10.1016/j.saa.2019.01.087DOI Listing
January 2019

Patient-reported minor adverse events after colonoscopy: a systematic review.

Acta Oncol 2019 Feb 20:1-7. Epub 2019 Feb 20.

a The Department of Surgery , Odense University Hospital , Denmark.

Objective: The purpose of this systematic review was to investigate the incidence and nature of minor adverse events (MAEs) after colonoscopy, and response rates to questionnaires concerning MAEs in patients undergoing colonoscopy.

Materials And Methods: A systematic literature search was conducted in the databases PubMed and Embase. Predictor variables were patient-reported MAEs after colonoscopy. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1574979DOI Listing
February 2019

In vivo evaluation of fluoride and sodium lauryl sulphate in toothpaste on buccal epithelial cells toxicity.

Acta Odontol Scand 2019 Feb 20:1-8. Epub 2019 Feb 20.

e Division for Mutagenesis , Institute for Medical Research and Occupational Health , Zagreb , Croatia.

Objectives: The present study addresses the effect of fluoride and sodium lauryl sulphate content of toothpaste on oral epithelial cells in vivo conditions.

Subjects And Method: Forty volunteers were assigned into two experimental groups, each of them applying the different brand of toothpaste. Every group has been using three different types of toothpaste (non-fluoride and non-SLS, fluoride and non-SLS, and the fluoride and SLS) of the same brand for 6 months, each for 2 months. Read More

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http://dx.doi.org/10.1080/00016357.2019.1577988DOI Listing
February 2019

Proton therapy for thymic malignancies: multi-institutional patterns-of-care and early clinical outcomes from the proton collaborative group and the university of Florida prospective registries.

Acta Oncol 2019 Feb 20:1-5. Epub 2019 Feb 20.

a University of Florida Health Proton Therapy Institute , Jacksonville , FL , USA.

Objective: Thymic malignancies (TM) are rare tumors with long-term survivorship, causing concerns for radiotherapy-related late side effects. Proton therapy (PT) reduces the radiation dose to organs at risk, potentially decreasing long-term toxicities while preserving disease control. We report patterns-of-care and early clinical outcomes after PT for thymoma and thymic carcinoma. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1575981DOI Listing
February 2019

In Vitro Susceptibility to Metronidazole of Tritrichomonas foetus Bovine Isolates from Argentina.

Acta Parasitol 2019 Feb 19. Epub 2019 Feb 19.

Instituto Multidisciplinario de Salud, Tecnología y Desarrollo (IMSaTeD), CONICET-UNSE, RN9, Km 1125, G4206XCP, Villa El Zanjón, Santiago del Estero, Argentina.

Background: Tritrichomonas foetus is the etiologic agent of the sexually transmitted disease Bovine Trichomonosis (BT). In Argentina, BT is endemic and represents a relevant health problem that causes reproductive inefficiency in cattle and large economic losses. Metronidazole is the drug of choice in the treatment of BT. Read More

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http://dx.doi.org/10.2478/s11686-019-00031-1DOI Listing
February 2019

2D-Single-crystal hexagonal gold nanosheets for ultra-trace voltammetric determination of captopril.

Mikrochim Acta 2019 Feb 19;186(3):195. Epub 2019 Feb 19.

Analytical Research Laboratory, Department of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, 98167-45845, Iran.

Two dimensional single-crystal hexagonal gold nanosheets (SCHGNSs) were prepared by microwave heating of a solution of HAuCl in an ionic liquid. The SCHGNSs were characterized by field emission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, atomic force microscopy and electrochemical impedance spectroscopy. The SCHGNSs were then used to modify a graphite paste electrode for voltammetric determination of the hypertension drug captopril (CAP). Read More

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http://dx.doi.org/10.1007/s00604-019-3260-9DOI Listing
February 2019

A randomized controlled trial comparing a telemedicine therapeutic intervention with routine care in adults with type 1 diabetes mellitus treated by insulin pumps.

Acta Diabetol 2019 Feb 19. Epub 2019 Feb 19.

Maccabi National Juvenile Diabetes Center, Raanana, Israel.

Aim: To examine the effectiveness and safety over a 12-month period of a telemedicine intervention in adults with type 1 diabetes (T1D) treated with insulin pumps.

Methods: 74 T1D patients on insulin pumps for at least 1 year (mean 19.5 [11. Read More

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http://dx.doi.org/10.1007/s00592-019-01300-1DOI Listing
February 2019

Long-term outcome after carpal tunnel release and identification of prognostic factors.

Acta Neurochir (Wien) 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurology, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532, SZ, Nijmegen, The Netherlands.

Background: The effectiveness of the surgical treatment of carpal tunnel syndrome (CTS) is well known on short term. However, limited data is available about long-term outcome after carpal tunnel release (CTR). The aims of this study were to explore the long-term outcome after CTR and to identify prognostic factors for long-term outcome. Read More

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http://dx.doi.org/10.1007/s00701-019-03839-yDOI Listing
February 2019

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.

Acta Neurochir (Wien) 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Lariboisiere Hospital, University of Paris Diderot, 2 rue Ambroise Paré, 75010, Paris, France.

Background: The relationship between increased meningioma incidence and growth and long-term hormonal therapy with cyproterone acetate (CPA) in women has been recently established in literature. Following the raise in awareness from hormonal treatment, we describe a potential relationship between the progesterone agonist nomegestrol acetate (NOMAC) and meningioma growth.

Methods: After implementation of a screening protocol to detect potential interactions between hormonal exposure and occurrence of meningioma, we identified patients taking NOMAC and newly diagnosed with a meningioma. Read More

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http://dx.doi.org/10.1007/s00701-019-03848-xDOI Listing
February 2019

Management of choroid plexus tumors-an institutional experience.

Acta Neurochir (Wien) 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Choroid plexus tumors are rare entities. Resection is the mainstay of treatment in grade I and grade II tumors and adjuvant treatment is usually reserved for the less frequent choroid plexus carcinoma (CPC). Outcome is not only related to their histological grade but also dependent on their size, location, and presence of often multifactorial disturbances of cerebrospinal fluid (CSF) circulation. Read More

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http://dx.doi.org/10.1007/s00701-019-03832-5DOI Listing
February 2019

Evaluation of the yield of post-clipping angiography and nationwide current practice.

Acta Neurochir (Wien) 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, University Medical Center Utrecht, Internal Postage: G03.124, PO-box 85500, 3584 CX, Utrecht, The Netherlands.

Background: Surgical treatment of intracranial saccular aneurysms aims to prevent (re)hemorrhage by complete occlusion of the aneurysmal lumen. It is unclear whether routine postoperative imaging, to assess aneurysmal occlusion, is necessary since intraoperative assessment by the neurosurgeon may be sufficient. We assessed routine clinical protocols for post-clipping imaging in the Netherlands and determined whether intraoperative assessment of aneurysm clippings sufficiently predicts aneurysm residuals. Read More

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http://dx.doi.org/10.1007/s00701-019-03834-3DOI Listing
February 2019

Inhibitors: A Need for Eradication?

Acta Haematol 2019 Feb 15;141(3):151-155. Epub 2019 Feb 15.

Division of Hematology/Oncology, Department of Pediatrics and Child Health Evaluative Sciences, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.

The development of inhibitors against factor VIII (FVIII) concentrates represents a significant treatment complication for hemophilia. Immune tolerance induction (ITI) therapy eradicates inhibitors in 60-80% of patients, resulting in a normal FVIII response. This article, based on presentations at the 6th International Coagulation Meeting, held in Barcelona, Spain, in September 2017, provides an overview of management approaches for patients with inhibitors and briefly tabulates four cases of ITI therapy (first-line or rescue ITI therapy in pediatric and adult patients) with successful outcomes. Read More

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http://dx.doi.org/10.1159/000495454DOI Listing
February 2019

Case Report: Development of Factor VIII Inhibitor in a Patient with an Uncommon de novo Mutation in the Factor VIII Gene.

Acta Haematol 2019 Feb 15;141(3):129-134. Epub 2019 Feb 15.

Division of Pediatric Hematology/Oncology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota,

The development of factor VIII inhibitors remains a significant clinical challenge in the management of hemophilia A. We present a patient of mixed ethnicity with severe hemophilia A who was found to have a F8 gene hemizygous c.5815G>T mutation resulting in an Ala1939Ser substitution (Ala1920Ser in legacy nomenclature) and possible splice site change that has been reported in only 1 patient previously. Read More

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http://dx.doi.org/10.1159/000495559DOI Listing
February 2019

Acquired Factor V Inhibitor with Symptoms and Titer of Inhibitor Differences: Report of Two Cases.

Acta Haematol 2019 Feb 15;141(3):148-150. Epub 2019 Feb 15.

Clinical Laboratory Center, The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou,

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http://dx.doi.org/10.1159/000496080DOI Listing
February 2019

Replacement Therapy with Glu-Plasminogen for the Treatment of Severe Respiratory and Auditory Complications of Congenital Plasminogen Deficiency.

Acta Haematol 2019 Feb 15;141(3):146-147. Epub 2019 Feb 15.

Prometic Life Sciences, Laval, Québec, Québec, Canada.

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http://dx.doi.org/10.1159/000495336DOI Listing
February 2019

Current Status of p16 Immunohistochemistry and HPV Testing in Fine Needle Aspiration Specimens of the Head and Neck.

Acta Cytol 2019 Feb 15:1-10. Epub 2019 Feb 15.

Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania,

Human papilloma virus (HPV)-related squamous cell carcinoma (SCC) is biologically unique and has a better prognosis than conventional SCC of the head and neck. p16 immunohistochemistry emerged as a valuable surrogate marker for HPV in oropharyngeal SCC. The criteria for a positive p16 result in tissue specimens are well established. Read More

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http://dx.doi.org/10.1159/000496158DOI Listing
February 2019

From HPV Infection to Lesion Progression: The Role of HLA Alleles and Host Immunity.

Acta Cytol 2019 Feb 15:1-11. Epub 2019 Feb 15.

Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.

Persistent high-risk human papillomavirus (HPV) infection has been associated with increased risk for cervical precancerous lesions and cancer. The host's genetic variability is known to play a role in the development of cervical cancer. The human leukocyte antigen (HLA) genes are highly polymorphic and have shown to be important risk determinants of HPV infection persistence and disease progression. Read More

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https://www.karger.com/Article/FullText/494985
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http://dx.doi.org/10.1159/000494985DOI Listing
February 2019
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Breast Fine Needle Aspiration Biopsy Cytology Using the Newly Proposed IAC Yokohama System for Reporting Breast Cytopathology: The Experience of a Single Institution.

Acta Cytol 2019 Feb 15:1-6. Epub 2019 Feb 15.

Institute of Molecular Pathology and Immunology, University of Porto, Porto,

Objective: Recently the International Academy of Cytology (IAC) proposed a new reporting system for breast fine needle aspiration biopsy (FNAB) cytology. We aimed to categorize our samples according to this classification and to assess the risk of malignancy (ROM) for each category as well as the diagnostic yield of breast FNAB.

Study Design: Breast FNAB specimens obtained between January 2007 and December 2017 were reclassified according to the newly proposed IAC Yokohama reporting system. Read More

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http://dx.doi.org/10.1159/000492638DOI Listing
February 2019

Liquid Biopsy beyond Circulating Tumor Cells and Cell-Free DNA.

Acta Cytol 2019 Feb 15:1-10. Epub 2019 Feb 15.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal (i3S), Porto,

Liquid biopsy represents the analysis of tumor-derived material in the blood and other body fluids of cancer patients. This portrays a minimally invasive detection tool for molecular biomarkers. Liquid biopsy has emerged as a complementary or alternative method to surgical biopsy. Read More

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http://dx.doi.org/10.1159/000493969DOI Listing
February 2019

Primary CNS Lymphoma in the Elderly: The Challenge.

Acta Haematol 2019 Feb 15;141(3):138-145. Epub 2019 Feb 15.

Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Primary central nervous system (CNS) lymphoma is an aggressive brain tumor sensitive to chemotherapy and radiotherapy. Its incidence has increased in the elderly, and they account for the majority of patients. The median survival of patients older than 70 years did not change over the last 40 years and remained in the range of 6-7 months. Read More

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http://dx.doi.org/10.1159/000495284DOI Listing
February 2019

Preclinical application of recombinant human bone morphogenetic protein 2 on bone substitutes for vertical bone augmentation: A systematic review and meta-analysis.

J Prosthet Dent 2019 Feb 16. Epub 2019 Feb 16.

Associate Professor, Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Electronic address:

Statement Of Problem: Recombinant human bone morphogenetic protein 2 (rhBMP-2) has been introduced to clinical practice because of its osteoinductive capacity. However, the evidence of its efficacy in vertical bone augmentation procedures is not clear.

Purpose: The purpose of this systematic review and meta-analysis was to investigate the efficacy of rhBMP-2 in vertical bone augmentation and to establish whether its addition in preclinical experiments (animal studies) would be sufficient to justify further clinical and histometric studies. Read More

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http://dx.doi.org/10.1016/j.prosdent.2018.09.008DOI Listing
February 2019

The evaluation of foot pressure and postural structure of national golfers.

Acta Orthop Traumatol Turc 2019 Feb 16. Epub 2019 Feb 16.

Halic University, School of Physical Education and Sport, Istanbul, Turkey.

Objective: The aim of this study was to perform the static and dynamic biomechanical assessment of postural structure and analyze variations of foot pressure in elite golfers.

Methods: A total of 8 golfers (3 female, mean age 15.33 ± 0. Read More

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http://dx.doi.org/10.1016/j.aott.2019.02.005DOI Listing
February 2019

Unlocking the hidden talent of DNA: Unexpected catalytic activity for colorimetric assay of alkaline phosphatase.

Anal Chim Acta 2019 May 21;1055:98-105. Epub 2018 Dec 21.

School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, PR China. Electronic address:

Carboxylic acids have been efficiently used to activate HO to form even more potent oxidant-peroxy acids through enzyme-catalyzed processes. By employing acetic acid as the activator, herein we report for the first time that cofactor-free DNA displays unexpected activity in HO-mediated oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) under mild conditions. A series of 10-nt oligonucleotides were rationally designed with various combinations of double nucleotides including TG, AG, CG, TA and AC respectively, which demonstrates that the catalytic performance of DNA is highly dependent upon the sequence composition, strand length and continuous nucleotides. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.035DOI Listing

A reusable electrochemical sensor for one-step biosensing in complex media using triplex-forming oligonucleotide coupled DNA nanostructure.

Anal Chim Acta 2019 May 21;1055:90-97. Epub 2018 Dec 21.

State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing, 210093, PR China. Electronic address:

Here we report an electrochemical DNA (E-DNA) sensor to detect a variety of analytes by using a novel interfacial probe that rationally integrates triplex-forming oligonucleotide (TFO) into a tetrahedral DNA nanostructure (TDN). In the presence of analyte, the blocked TFO is released and subsequently binds the edge of TDN to form a triplex DNA structure, which confines the redox reporter to be in close proximity to the underlying electrode and enhances the electrochemical signal. Thanks to the unique design and property of the probe, the proposed sensor could efficiently suppress the background signal (from 0. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.031DOI Listing

Oxidation etching induced dual-signal response of carbon dots/silver nanoparticles system for ratiometric optical sensing of HO and HO-related bioanalysis.

Anal Chim Acta 2019 May 15;1055:81-89. Epub 2018 Dec 15.

Key Laboratory of Eco-Environments in Three Gorges Reservoir Region (Ministry of Education), School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. Electronic address:

Ratiometric sensing suffers from less interference and can obtain more accurate results than single-signal assay. Here, a new ratiometric optical sensing strategy for HO detection is developed by etching silver nanoparticles (AgNPs) to deactivate fluorescence resonance energy transfer (FRET) and reduce Rayleigh scattering based on a hyphenated technique of fluorescence and second-order Rayleigh scattering (SRS). The ratiometric detection of HO is achieved through exploiting a hybrid system fabricated by fluorescent carbon dots and silver nanoparticles (CDs/AgNPs). Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.015DOI Listing

Paper-based microfluidic devices for glucose assays employing a metal-organic framework (MOF).

Anal Chim Acta 2019 May 18;1055:74-80. Epub 2019 Jan 18.

Department of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032-8202, USA. Electronic address:

This paper describes the development of two microfluidic paper-based analytical devices (μPADs), one well-based and the other based on a lateral flow assay (LFA) configuration, to detect glucose via a colorimetric assay using the solid metal-organic framework (MOF) Zr-PCN-222(Fe), to encapsulate glucose oxidase (GOx). The well-based platform consisted of laminate sheets and multiple layers of wax-printed chromatography paper. Solutions of KI and glucose placed into the well flowed through the device and reacted with the GOx@MOF species sandwiched between the paper layers realizing a yellow-brown color. Read More

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http://dx.doi.org/10.1016/j.aca.2019.01.009DOI Listing
May 2019
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Sub-femtomolar detection of HIV-1 gene using DNA immobilized on composite platform reinforced by a conductive polymer sandwiched between two nanostructured layers: A solid signal-amplification strategy.

Anal Chim Acta 2019 May 29;1055:7-16. Epub 2018 Dec 29.

Department of Chemistry, Razi University, Kermanshah, Iran.

This study introduces a signal amplification strategy rely on incorporating a specific polymer film between two typical nanostructured layers, aiming to improve the electrical properties of the platform to be able to transduce small binding event through sub-femtomolar detection of HIV-1 gene at the surface of the constructed biosensing device. The proposed composite was arrayed based on a conductive layer consist of p-aminobenzoic acid (PABA) sandwiched between the electrochemically reduced graphene oxide (ERGO) as the sub-layer, and the gold nanoparticles (AuNPs) as the interfacial layer. We computationally explored that how the use of such design enables the platform to transduce small changes in the interfacial properties of the biosensor, caused by low concentrations of HIV-1 gene, without needing any amplification strategy. Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.013DOI Listing

A self-digitization chip integrated with hydration layer for low-cost and robust digital PCR.

Anal Chim Acta 2019 May 21;1055:65-73. Epub 2018 Dec 21.

Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Defense Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, Chongqing University, Chongqing, 400044, China. Electronic address:

We present a self-discretization and zero-water-loss microfluidic digital PCR (dPCR) device to enable low-cost and robust quantitative nucleic acid assays. In this device, a thin void is integrated beneath the reaction chamber array. By utilizing the permeability of polydimethylsiloxane (PDMS) film, the integrated void serves a dual function: vacuum "accumulator" and hydration "reservoir". Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.029DOI Listing

Spatially resolved analysis of liquid crystal displays by laser ablation-atmospheric pressure chemical ionization-mass spectrometry.

Anal Chim Acta 2019 May 2;1055:56-64. Epub 2019 Jan 2.

Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 28/30, 48149, Münster, Germany. Electronic address:

In recent years, liquid crystal displays (LCDs) became more and more popular in industrial and consumer electronics applications. Unevenly distributed liquid crystals (LC) and the presence of organic contaminations in the LC layer, for example from the display sealant, can cause display defects and therefore lower the display quality. This work describes the development of a fast and easy screening method for display samples by laser ablation coupled to atmospheric pressure chemical ionization-mass spectrometry (LA-APCI-MS). Read More

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http://dx.doi.org/10.1016/j.aca.2018.12.048DOI Listing
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