674,671 results match your criteria Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists[Journal]


Perioperative hyperglycaemia in elective arthroplasties. Should we do better?

Acta Anaesthesiol Scand 2020 Jul 2. Epub 2020 Jul 2.

Department of Orthopaedics and Traumatology, Päijät-Häme Central Hospital, Lahti, Finland.

Background: Perioperative dysglycaemia is associated with deleterious outcomes but guidelines to improve glucose management are poorly or inconsistently adhered to. We evaluated glucose management among diabetic and nondiabetic patients undergoing elective hip or knee arthroplasty.

Methods: Capillary plasma glucose (CPG) was measured prospectively four times daily of 209 patients undergoing elective hip or knee surgery. Read More

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http://dx.doi.org/10.1111/aas.13666DOI Listing

Novel fluorescence probe based on bright emitted carbon dots for ClO detection in real water samples and living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 13;240:118592. Epub 2020 Jun 13.

Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, Shenzhen 518060, PR China.

Low-toxic and environmentally friendly carbon dots (CDs) have been extensively applied in various fields. CDs usually demonstrate excellent selectivity and high sensitivity, especially in ion detection. However, the most commonly used CDs are excited by ultraviolet (UV) light and emit weak fluorescence light, limiting their application in some fields. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118592DOI Listing

A SNARC-like effect for music notation: The role of expertise and musical instrument.

Acta Psychol (Amst) 2020 Jun 29;208:103120. Epub 2020 Jun 29.

Department of General Psychology, University of Padova, Italy.

The Spatial-Numerical Association of Response Codes (SNARC) suggests the existence of an association between number magnitude and response location, with faster left key-press responses to small numbers and faster right key-press responses to large numbers. We investigated whether a similar association exists between musical notes on the stave and the space of response execution, involving amateur and expert musicians (Experiment 1). Moreover, in Experiment 2 we further investigated such association in two groups of expert musicians (piano and transverse flute players) who differ in the note mapping on their instruments. Read More

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http://dx.doi.org/10.1016/j.actpsy.2020.103120DOI Listing

Optical emission spectroscopy of lead sulfide films plasma deposition.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 20;241:118629. Epub 2020 Jun 20.

Nizhny Novgorod State Technical University n.a. R.E. Alekseev, Nizhny Novgorod, Russia.

In-situ Optical Emission Spectroscopy (OES) combined with quantum chemical calculations was used as a powerful tool to find out the exited reactive species existing in plasma discharge during the process of lead sulfide chalcogenide materials deposition. Low temperature nonequilibrium RF (40.68 MHz) plasma at low pressure (0. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118629DOI Listing

One step synthesis of red-emitting fluorescence turn-on probe for nitroreductase and its application to bacterial detection and oral cancer cell imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 23;241:118637. Epub 2020 Jun 23.

Hospital of Stomatology, Jilin University, Qinghua Road 1500, Changchun 130021, China. Electronic address:

Nitroreductase (NTR) belongs to a class of flavin mononucleotide-dependent and flavin adenine dinucleotide-dependent cytoplasmic enzymes; its contents in tumor cells increase during hypoxia. The development of fluorescent probes for detection of NTR activity is of great significance for the study of the state of hypoxia in living organisms. In this paper, a red-emitting fluorescence turn-on probe EBI-NO was synthesized using a one-step method. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118637DOI Listing

The Congenital Toxoplasmosis Burden in Brazil: Systematic Review and Meta-analysis.

Acta Trop 2020 Jun 29:105608. Epub 2020 Jun 29.

Pathology Laboratory, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil.

Congenital toxoplasmosis is a zoonosis caused by the intracellular Apicomplexa protozoan Toxoplasma gondii. This infection causes subclinical or clinical lesions, such as retinochoroiditis and central nervous system lesions. The severity of fetal infection is related to the stage of pregnancy and the efficacy of the gestational treatment on fetal infection, whether it is achieved, or if it starts early. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105608DOI Listing

Long-term prognosis related to deep sedation in refractory status epilepticus.

Acta Neurol Scand 2020 Jul 2. Epub 2020 Jul 2.

Epilepsy Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Objective: To evaluate long-term prognosis in patients with refractory status epilepticus according to the level of sedation reached during drug-induced coma.

Material & Methods: Longitudinal study of patients with status epilepticus who received anesthetics to induce therapeutic coma. Demographic data, clinical and electroencephalographic characteristics were collected, as well as variables related to sedation. Read More

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http://dx.doi.org/10.1111/ane.13302DOI Listing

Is foetal alcohol syndrome in children as old as alcohol consumption?

Acta Paediatr 2020 Jul 1. Epub 2020 Jul 1.

National Drug Research Institute, Curtin University, Bentley, WA, Australia.

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http://dx.doi.org/10.1111/apa.15416DOI Listing

Correlates and genetics of self-reported sleep and awake bruxism in a nationwide twin cohort.

J Oral Rehabil 2020 Jul 2. Epub 2020 Jul 2.

Institute for Molecular Medicine Finland FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.

Background: Sleep bruxism (SB) and awake bruxism (AB) have been considered different entities, although co-occurrence between them has been shown. While genetic factors have a marked influence on phenotypic variance in liability to SB, this remains unclear for AB.

Aim: To examine the degree of co-occurrence of SB and AB, and whether they have common correlates, and also twin similarity of SB and AB bruxism traits by zygosity and sex. Read More

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http://dx.doi.org/10.1111/joor.13042DOI Listing

The Nematodes Thelazia gulosa Railiet and Henry, 1910 and Thelazia skrjabini Erschov, 1928 as a Cause of Blindness in European Bison (Bison bonasus) in Poland.

Acta Parasitol 2020 Jul 1. Epub 2020 Jul 1.

Witold Stefański Institute of Parasitology, Polish Academy of Sciences, Warsaw, Poland.

Purpose: The nematodes of the genus Thelazia are the cause of eye diseases of wild and domestic ruminants throughout the world. The aim of the study was to describe clinical cases of thelasiosis in European bison (Bison bonasus) in Poland, and provide morphometrical features of Thelazia gulosa Railiet and Henry, 1910 and Thelazia skrjabini Erschov, 1928 regarded as potentially useful for species differentiation METHODS: The conjunctival sacs, tear ducts, the surface of the cornea and nicitating membrane collected from bison were rinsed with saline solution. Any nematodes isolated from the sediment were subjected to morphometric analysis. Read More

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http://dx.doi.org/10.1007/s11686-020-00243-wDOI Listing

Intraoperative MRI guidance for right deep fronto-temporal glioma resection: how I do it.

Acta Neurochir (Wien) 2020 Jul 2. Epub 2020 Jul 2.

Department of Neurosurgery, Univ. Lille, CHU Lille, F-59000, Lille, France.

Background: For glial tumor management, the extent of resection (EOR) is the key to enhance tumor control and improve patient outcomes. Intraoperative MRI (IoMRI) neuronavigated microsurgery emerged as a useful neuroimaging tool for performing optimal and safe tumor resection.

Method: Here, we present the different steps of the microsurgical resection of a challenging deeply located right fronto-temporal glioma, using intraoperative MRI in an integrated IoMRI imaging platform. Read More

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http://dx.doi.org/10.1007/s00701-020-04474-8DOI Listing

Screen-printed electrodes modified with carbon black and polyelectrolyte films for determination of cancer marker carbohydrate antigen 19-9.

Mikrochim Acta 2020 Jul 1;187(7):417. Epub 2020 Jul 1.

São Carlos Institute of Physics, University of São Paulo, São Carlos, SP, 13560-970, Brazil.

Electrochemical immunosensors have been developed to determine the carbohydrate antigen 19-9 (CA19-9). They are based on screen-printed carbon electrodes (SPCEs) coated with layer-by-layer (LbL) films of carbon black (CB) and polyelectrolytes. Owing to a suitable choice of LbL film architecture, the procedures for immobilization of anti-CA19-9 antibodies on the electrode surfaces were straightforward. Read More

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http://dx.doi.org/10.1007/s00604-020-04404-6DOI Listing

Smartphone-based enzyme-free fluorescence sensing of organophosphate DDVP.

Mikrochim Acta 2020 Jul 2;187(7):419. Epub 2020 Jul 2.

State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China.

A novel fluorescence strategy based on the outstanding catalytic capability of CuS nanoparticles (CuS) has been developed for highly sensitive and specific determination of o,o-dimethyl-o-2,2-dichlorovinyl phosphate (DDVP) under enzyme-free and hydrogen peroxide (HO)-free conditions. In the presence of DDVP, CuS can catalyze non-fluorescence substratum of Amplex red (AR) into resorufin, which exhibits fluorescence emission at 584 nm under excitation at 540 nm. The sensing system exhibits outstanding specificity and only responds to DDVP and no other organophosphorus pesticides (OPs). Read More

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http://dx.doi.org/10.1007/s00604-020-04384-7DOI Listing

Preparation of gold nanorod-incorporated monolith for solid phase extraction of polycyclic aromatic hydrocarbons.

Mikrochim Acta 2020 Jul 1;187(7):418. Epub 2020 Jul 1.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.

An organic-inorganic hybrid monolithic column doped with gold nanorods (AuNRs) was prepared and evaluated for solid phase extraction (SPE) of polycyclic aromatic hydrocarbons (PAHs). Excellent dispersibility of AuNRs in binary green porogen system consisting of 1-hexyl-3-methylimidazolium tetrafluoroborate and deep eutectic solvents (DESs) was confirmed by energy dispersive spectrometry (EDS). The particle size of the resulting AuNRs (70-90 nm) was thoroughly examined by a transmission electron microscopy (TEM). Read More

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http://dx.doi.org/10.1007/s00604-020-04401-9DOI Listing

Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts.

Acta Pharmacol Sin 2020 Jul 1. Epub 2020 Jul 1.

Cardiac Electrophysiological Research Laboratory, Medical College, Wuhan University of Science and Technology, Wuhan, 430065, China.

Eleutheroside B (EB) is the main active constituent derived from the Chinese herb Acanthopanax senticosus (AS) that has been reported to possess cardioprotective effects. In this study we investigated the effects of EB on cardiac electrophysiology and its suppression on atrial fibrillation (AF). Whole-cell recording was conducted in isolated rabbit atrial myocytes. Read More

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http://dx.doi.org/10.1038/s41401-020-0453-zDOI Listing

Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington's disease.

Acta Neuropathol Commun 2020 Jul 1;8(1):97. Epub 2020 Jul 1.

Department of Biological Sciences, The State University of New York at Buffalo, New York, 14260, USA.

Huntington's disease (HD) is characterized by protein inclusions and loss of striatal neurons which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the huntingtin (HTT) gene. Both polyQ expansion and loss of HTT have been shown to cause axonal transport defects. While studies show that HTT is important for vesicular transport within axons, the cargo that HTT transports to/from synapses remain elusive. Read More

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http://dx.doi.org/10.1186/s40478-020-00964-zDOI Listing

Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.

Acta Neuropathol Commun 2020 Jul 1;8(1):96. Epub 2020 Jul 1.

Departments of Neurology and of Neuroscience, Program in Cellular Neuroscience, Neurodegeneration, Repair, Yale University School of Medicine, New Haven, CT, 06536, USA.

Accumulation of misfolded phosphorylated Tau (Tauopathy) can be triggered by mutations or by trauma, and is associated with synapse loss, gliosis, neurodegeneration and memory deficits. Fyn kinase physically associates with Tau and regulates subcellular distribution. Here, we assessed whether pharmacological Fyn inhibition alters Tauopathy. Read More

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http://dx.doi.org/10.1186/s40478-020-00976-9DOI Listing

Effect of a multi-citrus extract-based feed additive on the survival of rainbow trout (Oncorhynchus mykiss) following challenge with Lactococcus garvieae.

Acta Vet Scand 2020 Jul 1;62(1):38. Epub 2020 Jul 1.

Department of Animal Pathology, Faculty of Veterinary Sciences, Universidad de Zaragoza, Saragossa, 50013, Spain.

Growing global concerns about antibiotic resistance have generated a considerable interest in the search for alternative environmental-friendly approaches. This study was aimed to assess the antimicrobial activity of a multi-citrus extract-based feed additive (Biocitro) against some fish pathogens, as well as evaluate its capacity to protect rainbow trout (Oncorhynchus mykiss) to lactococcosis. A broth dilution method was used to determine the minimum inhibitory concentration (MIC) of Biocitro, and the results showed a strong antibacterial activity against Aeromonas salmonicida, Lactococcus garvieae and Yersinia ruckeri with MIC values of 2. Read More

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http://dx.doi.org/10.1186/s13028-020-00536-0DOI Listing

Usability of the lateral decubitus position on four-dimensional ultra-low-dose computed tomography for the detection of localized pleural adhesion in the pulmonary apical region.

Acta Radiol 2020 Jul 1:284185120930611. Epub 2020 Jul 1.

Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan.

Background: Localized pleural adhesion (LPA) evaluation in the apical region is difficult even with four-dimensional ultra-low-dose computed tomography (4D-ULDCT) in the supine position due to smaller pleural movements.

Purpose: To assess usability of 4D-ULDCT in the lateral decubitus (LD) position for LPA detection in the apical region.

Material And Methods: Forty-seven patients underwent 4D-ULDCT of a single respiration cycle with 16-cm coverage of body axis in supine and LD positions with the affected lung uppermost. Read More

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http://dx.doi.org/10.1177/0284185120930611DOI Listing

Serum Lactate Dehydrogenase Can Be Used as a Factor for Re-Evaluating First-Relapsed Multiple Myeloma.

Acta Haematol 2020 Jul 1:1-8. Epub 2020 Jul 1.

Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China,

Background: Serum lactate dehydrogenase (LDH) is an adverse prognostic factor for newly diagnosed multiple myeloma (MM). However, the role of LDH in the prognosis of MM patients with relapse has not yet been thoroughly explored.

Objectives: To explore the prognostic value of LDH in patients with first-relapsed MM. Read More

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http://dx.doi.org/10.1159/000505737DOI Listing

Solid-state effect on luminescent properties of thermally activated delayed fluorescence molecule with aggregation induced emission: A theoretical perspective.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 22;241:118634. Epub 2020 Jun 22.

Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, Institute of Materials and Clean Energy, School of Physics and Electronics, Shandong Normal University, Jinan 250014, China; Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates (South China University of Technology), Guangzhou 510640, China. Electronic address:

Solid-state effect plays an important role in defining the nature of excited states for thermally activated delayed fluorescence (TADF) molecules and further affects their luminescence properties. Theoretical investigation of photophysical properties with explicit consideration of intermolecular interactions in solid phase, is highly desired. In this work, the luminescent properties of new TADF molecule SBF-BP-DMAC with aggregation induced emission (AIE) feature are theoretically studied both in solution and solid phase. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118634DOI Listing

Physicochemical, in-vitro therapeutic activity and biomolecular interaction studies of Mn(II), Ni(II) and Cu(II) complexes tethered with ON ligand backbone.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 20;241:118613. Epub 2020 Jun 20.

Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bengaluru 562112, Karnataka, India. Electronic address:

Two major health crisis of today's world are antimicrobial drug resistance and type II diabetes. To tackle them, there is an immediate requirement for the development of new and safer drugs and the present work is one such quest for novel and efficient drug candidates. We have developed three trace metal coordination compounds tethered with a reduced salen ligand {H(hpdbal)-an} (L), namely, a manganese-salan complex, [Mn(HO){(hpdbal)-an}] (1), a nickel-salan complex, [Ni{(hpdbal)-an}] (2) and a copper-salan complex, [Cu{(hpdbal)-an}] (3). Read More

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http://dx.doi.org/10.1016/j.saa.2020.118613DOI Listing

ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 22;241:118636. Epub 2020 Jun 22.

Department of Chemical Engineering, Imperial College London, UK. Electronic address:

Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is a label-free, non-destructive technique that can be applied to a vast range of biological applications, from imaging cancer tissues and live cells, to determining protein content and protein secondary structure composition. This review summarises the recent advances in applications of ATR-FTIR spectroscopy to biopharmaceuticals, the application of this technique to biosimilars, and the current uses of FTIR spectroscopy in biopharmaceutical production. We discuss the use of ATR-FTIR spectroscopic imaging to investigate biopharmaceuticals, and finally, give an outlook on the possible future developments and applications of ATR-FTIR spectroscopy and spectroscopic imaging to this field. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118636DOI Listing

An ultrasensitive chemiluminescence assay for 4-nitrophenol by using luminol-NaIO reaction catalyzed by copper, nitrogen co-doped carbon dots.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 18;241:118608. Epub 2020 Jun 18.

Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz 5166616471, Iran. Electronic address:

A chemiluminescence (CL) assay on the basis of the tremendous enhancing effect of copper and nitrogen co-doped carbon dots (Cu,N-CDs) on the luminol-NaIO reaction was introduced for the determination of nanomolar levels of 4-nitrophenol (4-NP). Cu,N-CDs were synthesized by a hydrothermal approach and characterized by TEM, XRD, EDX, and FTIR analysis. The potential CL mechanism was elucidated by recording the CL spectrum and by evaluating the influence of reactive oxygen species. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118608DOI Listing

A novel fluorescent probe with dual-sites for simultaneously monitoring metabolisms of cysteine in living cells and zebrafishes.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 15;241:118602. Epub 2020 Jun 15.

Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.

Understanding cellular metabolism holds immense potential for developing new drugs that regulate metabolic pathways. Two gas signal molecules, SO and HS, are the main metabolites from cysteine (Cys) via oxidation and desulfurization pathways, respectively. However, a few fluorescent probes for real-time monitor of the metabolic pathways of cysteine have been reported. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118602DOI Listing

Facile synthesis of Au nanoparticle-coated FeO magnetic composite nanospheres and their application in SERS detection of malachite green.

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 26;241:118532. Epub 2020 May 26.

Beijing Bioprocess Key Laboratory, Beijing University of Chemical Technology, Beijing 100029, China; College of Mathematics & Physics, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:

A facile method for synthesizing Au nanoparticle-coated FeO magnetic composite nanospheres (FeO@Au MCS) via seed-mediated growth and iterative reduction is reported. The nanospheres were then successfully used to detect malachite green (MG) residues in water bodies via surface-enhanced Raman scattering (SERS) technique. FeO@Au MCS has excellent optical properties and superparamagnetism; it can be dispersed into the solution to fully adsorb target molecules and then collected with a magnet to increase the molecular density and the number of SERS hot spots. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118532DOI Listing

Influence of cytosolic conditions on the reaction equilibrium and the reaction enthalpy of the enolase reaction accessed by calorimetry and van 't HOFF.

Biochim Biophys Acta Gen Subj 2020 Jun 28:129675. Epub 2020 Jun 28.

UFZ - Helmholtz Centre for Environmental Research, Dept. Environmental Microbiology, Permoserstr. 15, D-04318 Leipzig, Germany. Electronic address:

Background: Thermodynamic methods are finding more and more applications in systems biology, which attempts to understand cell functions mechanistically. Unfortunately, the state variables used (reaction enthalpy and Gibbs energy) do not take sufficient account of the conditions inside of cells, especially the crowding with macromolecules.

Methods: For this reason, the influence of crowding agents and various other parameters such as salt concentrations, pH and temperature on equilibrium position and reaction enthalpy of the glycolytic example reaction 9 (2-Phospoglycerate - > Phosphoenolpyruvate + HO) was investigated. Read More

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http://dx.doi.org/10.1016/j.bbagen.2020.129675DOI Listing

A Preliminary Evaluation of a Locally Produced Biotinylated Polyclonal Anti-rabies Antibody for Direct Rapid Immunohistochemical Test (DRIT) in the Philippines.

Acta Trop 2020 Jun 28:105610. Epub 2020 Jun 28.

Department of Veterinary Science, National Institute for Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan.

Rabies is a fatal zoonotic disease endemic in developing countries of Asia and Africa. Recently, the direct rapid immunohistochemical test (DRIT) was recommended by the World Health Organization (WHO) and the World Organization for Animal Health (OIE) as a diagnostic test for rabies. Therefore, a biotinylated polyclonal antibody (pAb) against the rabies lyssavirus (RABV) nucleoprotein was developed using a plasmid cDNA vaccine derived from a challenge virus standard 11 strain. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105610DOI Listing

Children born before 32 weeks of gestation displayed impaired reading fluency, comprehension, and spelling skills at nine years of age.

Acta Paediatr 2020 Jul 1. Epub 2020 Jul 1.

Child Language Research Center, Faculty of Humanities, University of Oulu, PL 1000, 90014, Oulu, Finland.

Aim: Our aim was to study whether prematurity, associated with prenatal and neonatal risk factors, affects specific literacy skills among schoolchildren born at a very low gestational age (VLGA) of <32 weeks.

Methods: The study group comprised 76 prospectively followed VLGA children born between November 1998 and November 2002 at Oulu University Hospital, Finland, and 51 term controls. The median gestational age of the VLGA children was 29. Read More

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http://dx.doi.org/10.1111/apa.15456DOI Listing

Adverse pregnancy outcomes and maternal health: action needed for long-term benefit.

Acta Obstet Gynecol Scand 2020 Jul 1. Epub 2020 Jul 1.

Department of Clinical Intervention, Science & Technology (CLINTEC), Karolinksa Institutet, Stockholm, Sweden.

In recent years, high-quality evidence has been accumulating that pregnancy complications are linked to a range of chronic diseases in later life. Pregnancy is regarded as a metabolic "stress test" which may unmask women's underlying risk of future cardiovascular disease (CVD) or chronic kidney disease (CKD). However, the potential for this information to be used in long-term cardio-renal risk reduction has not been fully realised. Read More

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http://dx.doi.org/10.1111/aogs.13945DOI Listing

Unplanned out-of-hospital deliveries in Finland: a national register study on incidence, characteristics and maternal and infant outcomes.

Acta Obstet Gynecol Scand 2020 Jul 1. Epub 2020 Jul 1.

Department of Pediatrics, Tampere University Hospital, Tampere, Finland.

Introduction: Unplanned out-of-hospital deliveries (UOHDs) have earlier been related to higher perinatal mortality and morbidity, but recent research has not given much attention to them. Our aim was to evaluate the incidence, characteristics, risk factors, and maternal and perinatal mortality and morbidity in UOHDs in Finland.

Material And Methods: We conducted a national register study on births, causes of death, and congenital anomalies for all live and stillbirths over 1996-2013. Read More

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http://dx.doi.org/10.1111/aogs.13947DOI Listing

Cerebral autoregulation after aneurysmal subarachnoid haemorrhage. A preliminary study comparing dexmedetomidine to propofol and/or midazolam.

Acta Anaesthesiol Scand 2020 Jul 1. Epub 2020 Jul 1.

Division of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital and University of Turku, Turku, Finland.

Background: Cerebral autoregulation is often impaired after aneurysmal subarachnoid haemorrhage (aSAH). Dexmedetomidine is being increasingly used, but its effects on cerebral autoregulation in patients with aSAH have not been studied before. Dexmedetomidine could be a useful sedative in patients with aSAH as it enables neurological assessment during the infusion. Read More

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http://dx.doi.org/10.1111/aas.13663DOI Listing

Induction of labor and nulliparity: a nation-wide clinical practice pilot evaluation.

Acta Obstet Gynecol Scand 2020 Jul 1. Epub 2020 Jul 1.

Department of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway.

Introduction: Induction of labor has become an increasingly common obstetric procedure. However, in nulliparous women or women with a previous cesarean section, induction of labor can pose a clinical challenge. Despite an overall expansion of medical indications for labor induction, there is little international consensus regarding the criteria for induction of labor, or for the recommended methods among nulliparous women. Read More

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http://dx.doi.org/10.1111/aogs.13948DOI Listing

Combined transcervical endometrial resection and levonorgestrel device treatment compared to transcervical endometrial resection for abnormal uterine bleed.

Acta Obstet Gynecol Scand 2020 Jul 1. Epub 2020 Jul 1.

Department. of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark.

Introduction: Transcervical resection of the endometrium (TCRE) is a first line surgical treatment of abnormal uterine bleeding. However, many patients experience unsuccessful results, causing hysterectomy in up 17% of cases. The aim of this study was to describe the odds of hysterectomy in patients with abnormal uterine bleeding, treated with TCRE and Levonorgestrel intrauterine device (TCRE+LNG-IUD) or TCRE alone. Read More

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http://dx.doi.org/10.1111/aogs.13949DOI Listing

Association between transfusion of blood products and acute kidney injury following cardiac surgery.

Acta Anaesthesiol Scand 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiothoracic Anaesthesiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Acute kidney injury (AKI) is a serious complication following cardiac surgery associated with increased mortality. Red blood cell transfusion enhances the risk of developing AKI. However, the impact of other blood products on AKI is virtually unexplored. Read More

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http://dx.doi.org/10.1111/aas.13664DOI Listing

Cadmium in bone cement induces necrosis and decreases the viability of residual osteosarcoma cells: A xenograft study.

Acta Orthop Traumatol Turc 2020 Jul 1. Epub 2020 Jul 1.

Department of Orthopedics, Dokuz Eylül University, School of Medicine, İzmir, Turkey.

Objective: The aim of this study was to show whether local application of cadmium-impregnated bone cement can induce apoptosis and decrease the viability of residual osteosarcoma (OS) cells in nude mice.

Methods: K7M2 tumorigenic OS cell line was cultivated in vitro. The xenograft tumor model was formed by subcutaneously adding the tumor cells to athymic nude mice. Read More

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http://dx.doi.org/10.5152/j.aott.2020.20247DOI Listing

Diagnostic accuracy of ultrasound in subscapularis tendon abnormalities and the importance of operator experience.

Acta Orthop Traumatol Turc 2020 Jul 1. Epub 2020 Jul 1.

Clinic of Pediatric Hematology, Lösante Hospital, Ankara, Turkey.

Objective: This study aimed to investigate the reasons behind the compliance, diagnostic success, and failure of ultrasound (US) examinations of two radiologists with reference to magnetic resonance imaging (MRI) in the abnormalities of subscapularis (SSC) tendon, including tendinosis.

Methods: One less experienced radiologist (operator-1) and one senior radiologist, experienced in the musculoskeletal US (operator-2), performed the shoulder US on 78 patients (mean age: 53.18 ± 10. Read More

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http://dx.doi.org/10.5152/j.aott.2020.20146DOI Listing

Characterization of uveal melanoma clinical trial design: a systematic review to establish an elusive standard of care.

Acta Oncol 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.

: There is currently no FDA or EMA-approved standard of care for metastatic uveal melanoma.: A systematic review of all interventional uveal melanoma trials on the ClinicalTrials.gov database and EU Clinical Trials Register was conducted from January 15, 2019 through November 30, 2019. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1787508DOI Listing

Salivary gland ultrasound findings are associated with clinical and serologic features in primary Sjögren's syndrome patients.

Acta Reumatol Port 2020 Jan-Mar;45(1):76-77

Unidade Local de Saúde do Alto Minho.

Objective: Salivary gland ultrasound (SGUS) has been applied in the diagnosis of primary Sjögren's syndrome (pSS). To investigate the association of SGUS findings with clinical and analytical features of pSS patients.

Material And Methods: 54 pSS patients underwent SGUS evaluation. Read More

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Juvenile bullous systemic lupus erythematosus - case report.

Acta Reumatol Port 2020 Jan-Mar;45(1):74-75

Hospital Garcia de Orta.

Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune subepidermal blistering disease, with few cases described in childhood. We report a case of bullous systemic lupus erythematosus refractory to corticosteroid therapy in a 16-year-old female who was successfully treated with low dose dapsone. We highlight the rarity and the relevance of skin biopsy for a correct diagnosis of BSLE. Read More

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Advanced pharmacological therapies for neurofibromatosis type 1-related tumors.

Acta Biomed 2020 Jun 30;91(7-S):101-114. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Neurofibromatosis Type 1 (NF1) is an autosomal dominant tumor-predisposition disorder that is caused by a heterozygous loss of function variant in the NF1 gene, which encodes a protein called neurofibromin. The absence of neurofibromin causes increased activity in the Rat sarcoma protein (RAS) signalling pathway, which results in an increased growth and cell proliferation. As a result, both oncological and non-oncological comorbidities contribute to a high morbidity and mortality in these patients. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9961DOI Listing

Targeting the medulloblastoma: a molecular-based approach.

Acta Biomed 2020 Jun 30;91(7-S):79-100. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Uni-versity of Pavia, Pavia, Italy.

Background: The lack of success of standard therapies for medulloblastoma has highlighted the need to plan a new therapeutic approach. The purpose of this article is to provide an overview of the novel treatment strategies based on the molecular characterization and risk categories of the medulloblastoma, also focusing on up-to-date relevant clinical trials and the challenges in translating tailored approaches into clinical practice.

Methods: An online search of the literature was carried out on the PubMed/MEDLINE and ClinicalTrials. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9958DOI Listing

Potential roads for reaching the summit: an overview on target therapies for high-grade gliomas.

Acta Biomed 2020 Jun 30;91(7-S):61-78. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Uni-versity of Pavia, Pavia, Italy.

The tailored targeting of specific oncogenes represents a new frontier in the treatment of high-grade glioma in the pursuit of innovative and personalized approaches. The present study consists in a wide-ranging overview of the target therapies and related translational challenges in neuro-oncology.

Methods: A review of the literature on PubMed/MEDLINE on recent advances concerning the target therapies for treatment of central nervous system malignancies was carried out. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9956DOI Listing

The impact of stem cells in neuro-oncology: applications, evidence, limitations and challenges.

Acta Biomed 2020 Jun 30;91(7-S):51-60. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Uni-versity of Pavia, Pavia, Italy.

Background: Stem cells (SCs) represent a recent and attractive therapeutic option for neuro-oncology, as well as for treating degenerative, ischemic and traumatic pathologies of the central nervous system. This is mainly because of their homing capacity, which makes them capable of reaching the inaccessible SC niches of the tumor, therefore, acting as living drugs. The target of the study is a comprehensive overview of the SC-based therapies in neuro-oncology, also highlighting the current translational challenges of this type of approach. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9955DOI Listing

Gene therapies for high-grade gliomas: from the bench to the bedside.

Acta Biomed 2020 Jun 30;91(7-S):32-50. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Uni-versity of Pavia, Pavia, Italy.

Background: Gene therapy is the most attractive therapeutic approach against high-grade gliomas (HGGs). This is because of its theoretical capability to rework gene makeup in order to yield oncolytic effects. However, some factors still limit the upgrade of these therapies at a clinical level of evidence. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9953DOI Listing

Adoptive immunotherapies in neuro-oncology: classification, recent advances, and translational challenges.

Acta Biomed 2020 Jun 30;91(7-S):18-31. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Uni-versity of Pavia, Pavia, Italy.

Background: Adoptive immunotherapies are among the pillars of ongoing biological breakthroughs in neuro-oncology, as their potential applications are tremendously wide. The present literature review comprehensively classified adoptive immunotherapies in neuro-oncology, provides an update, and overviews the main translational challenges of this approach.

Methods: The PubMed/MEDLINE platform, Medical Subject Heading (MeSH) database, and ClinicalTrials. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9952DOI Listing

Innovative therapies for malignant brain tumors: the road to a tailored cure.

Acta Biomed 2020 Jun 30;91(7-S):5-17. Epub 2020 Jun 30.

Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, Uni-versity of Pavia, Pavia, Italy.

Background: Immune tolerance, immune escape, neoangiogenesis, phenotypic changes, and glioma stem cells are all responsible for the resistance of malignant brain tumors to current therapies and persistent recurrence. The present study provides a panoramic view of innovative therapies for malignant brain tumors, especially glioblastoma, aimed at achieving a tailored approach.

Methods: PubMed/Medline and ClinicalTrials. Read More

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http://dx.doi.org/10.23750/abm.v91i7-S.9951DOI Listing

On an extension of Krivovichev's complexity measures.

Acta Crystallogr A Found Adv 2020 Jul 30;76(Pt 4):534-548. Epub 2020 Jun 30.

Institute of Physics of the Academy of Sciences of the Czech Republic, Na Slovance 2, 182 21 Praha 8, Czech Republic.

An extension is proposed of the Shannon entropy-based structural complexity measure introduced by Krivovichev, taking into account the geometric coordinational degrees of freedom a crystal structure has. This allows a discrimination to be made between crystal structures which share the same number of atoms in their reduced cells, yet differ in the number of their free parameters with respect to their fractional atomic coordinates. The strong additivity property of the Shannon entropy is used to shed light on the complexity measure of Krivovichev and how it gains complexity contributions due to single Wyckoff positions. Read More

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http://dx.doi.org/10.1107/S2053273320006634DOI Listing

Derived crystal structure of martensitic materials by solid-solid phase transformation.

Acta Crystallogr A Found Adv 2020 Jul 30;76(Pt 4):521-533. Epub 2020 Jun 30.

Mechanical and Aerospace Engineering, Hong Kong University of Science and Technology, Hong Kong.

A mathematical description of crystal structure is proposed consisting of two parts: the underlying translational periodicity and the distinct atomic positions up to the symmetry operations in the unit cell, consistent with the International Tables for Crystallography. By the Cauchy-Born hypothesis, such a description can be integrated with the theory of continuum mechanics to calculate a derived crystal structure produced by solid-solid phase transformation. In addition, the expressions for the orientation relationship between the parent lattice and the derived lattice are generalized. Read More

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http://dx.doi.org/10.1107/S2053273320006087DOI Listing

Theoretical study of the properties of X-ray diffraction moiré fringes. III. Theoretical simulation of previous experimental moiré images.

Acta Crystallogr A Found Adv 2020 Jul 30;76(Pt 4):503-520. Epub 2020 Jun 30.

Sakai 5-13-2-A322, Musashino-shi, Tokyo 180-0022, Japan.

As a practical confirmation of a recently published X-ray moiré-fringe theory [Yoshimura (2015). Acta Cryst. A71, 368-381], computer simulations using this theory were conducted for previous experimental moiré images of a strained bicrystal specimen [Yoshimura (1996). Read More

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http://dx.doi.org/10.1107/S205327332000532XDOI Listing
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