4,214 results match your criteria Acta Virologica[Journal]


Genomic characteristics and phylogenetic analysis of the first H12N2 influenza A virus identified from wild birds, China.

Acta Virol 2020 ;64(1):104-110

In this report, an H12N2 influenza A virus was identified from a fecal sample in the falcated teal, Anas falcata, located in the Dongting Lake wetland. This is the first report of H12N2 IAV detected from wild birds in China. Phylogenetic analysis showed that all eight segments of this H12N2 virus clustered in the Eurasian lineage. Read More

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http://dx.doi.org/10.4149/av_2020_113DOI Listing
January 2020

Occurrence and detection of little cherry virus 1, little cherry virus 2, cherry green ring mottle virus, cherry necrotic rusty mottle virus, and cherry virus A in stone fruit trees in Poland.

Acta Virol 2020 ;64(1):100-103

To investigate the occurrence of little cherry virus 1 (LChV-1), little cherry virus 2 (LChV-2), cherry green ring mottle virus (CGRMV), cherry necrotic rusty mottle virus (CNRMV), and cherry virus A (CVA) in stone fruit trees in Poland, leaf samples were collected from sweet and sour cherry, peach, and apricot trees. Two sets of primers were used to increase the effectiveness of virus detection. The RT-PCR results indicated that the most frequently detected virus in all of the tested samples was CVA (60%), followed by CGRMV (13%), CNRMV (12%), LChV-1 (11%), and LChV-2 (4%). Read More

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http://dx.doi.org/10.4149/av_2020_112DOI Listing
January 2020

Targeting Epstein-Barr virus nuclear antigen 1 (EBNA-1) with Murraya koengii bio-compounds: An in-silico approach.

Acta Virol 2020 ;64(1):93-99

Epstein-Barr virus (EBV), a B lymphotrophic herpesvirus associated with various forms of tumors, exhibits several latency phases with expressed EBV nuclear antigen 1 (EBNA-1). In the search of novel EBV-inhibiting targets, to curb the menace of EBV-borne lymphotropic transformations, EBNA-1 protein might serve as a best target for novel  antiviral natural compounds. This study is thus aimed to explore the inhibitory potential of Muuraya koengii bioactive compounds isomahanine, murrayanol and mahanimbine against the EBNA-1 of EBV. Read More

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http://dx.doi.org/10.4149/av_2020_111DOI Listing
January 2020

Full genome sequence of a chrysanthemum-infecting tomato spotted wilt virus isolate from Zimbabwe obtained by next-generation sequencing.

Acta Virol 2020 ;64(1):88-92

Tomato spotted wilt virus (TSWV) is an economically important pathogen of many crops worldwide. However, prior to this study, only one complete genome sequence of an African TSWV isolate was available in public databases. This limits genetic diversity and evolutionary studies of the pathogen on the continent. Read More

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http://dx.doi.org/10.4149/av_2020_107DOI Listing
January 2020

Influenza A virus lacking the effector and C terminal domains of NS1 protein induces cytokines associated with high pathogenicity in mice.

Acta Virol 2020 ;64(1):78-87

Non-structural NS1 protein of influenza A virus counters host antiviral defences by antagonizing the interferon response. The C-terminal effector domain suppresses the host response and is associated with the pathogenicity of the virus.  To better understand the regulatory role of the C-terminal domain, we used reverse genetics system to generate NS1-truncated virus (NS80) and compared the cytokine profiles in the lungs of mice infected with the NS80 mutant and with the control virus A/WSN/33 (WSN). Read More

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http://dx.doi.org/10.4149/av_2020_110DOI Listing
January 2020

Two genetically similar H9N2 influenza viruses isolated from different species show similar virulence in minks but different virulence in mice.

Acta Virol 2020 ;64(1):67-77

The H9N2 influenza virus has been frequently endemic in poultry, infected mammals and humans and has threatened public health. It is therefore imperative to understand the molecular mechanism enabling this virus to jump from avian to mammalian species. In this study, two H9N2 influenza viruses were isolated from the same region in eastern China but from different hosts; one was isolated from mink and named A/Mink/Shandong/WM01/2014(H9N2)(WM01), while the other was isolated from chicken and named A/Chicken/Shandong/LX830/2014(H9N2)(LX830). Read More

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http://dx.doi.org/10.4149/av_2020_109DOI Listing
January 2020

Characterization of a P18 protein in the S1 segment of the novel duck reovirus genome.

Acta Virol 2020 ;64(1):59-66

Novel duck reovirus (NDRV), the prototype strain of avian orthoreoviruses, continues to circulate among ducks. Analysis of its genome suggested that a putative second open reading frame in the S1 segment encodes a 162-amino acid nonstructural protein with size of 18 kDa, provisionally designated P18. This protein is different from the 17 kDa nonstructural protein encoded in the same open reading frame in other avian orthoreoviruses, which is designated P17 and consists of 146 amino acids. Read More

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http://dx.doi.org/10.4149/av_2020_108DOI Listing
January 2020

Thiol/disulfide exchange occurs in rotavirus structural proteins during contact with intestinal villus cell surface.

Acta Virol 2020 ;64(1):44-58

Protein disulfide isomerase (PDI) is an enzyme that catalyzes disulfide bond reduction or formation and rearrangements of disulfide bridges, and also functions as a chaperone. During entry of some of the viruses PDI participates in thiol-disulfide exchange. Previous reports show that rotavirus entry is interfered by impermeant thiol/disulfide exchange inhibitors and antibodies against PDI. Read More

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http://dx.doi.org/10.4149/av_2020_106DOI Listing
January 2020

Identification of Trichosanthes associated rhabdovirus 1, a novel member of the genus Cytorhabdovirus of the family Rhabdoviridae, in the Trichosanthes kirilowii transcriptome.

Authors:
C J Goh D Park Y Hahn

Acta Virol 2020 ;64(1):36-43

The genome sequence of a novel RNA virus, Trichosanthes associated rhabdovirus 1 (TrARV1), was identified in a transcriptome dataset isolated from a root sample of Trichosanthes kirilowii, which is a flowering plant belonging to the family Cucurbitaceae. The fruits, seeds, and root tubers of T. kirilowii have been used clinically in traditional Chinese medicine. Read More

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http://dx.doi.org/10.4149/av_2020_105DOI Listing
January 2020

Identification of Pistacia-associated flexivirus 1, a putative mycovirus of the family Gammaflexiviridae, in the mastic tree (Pistacia lentiscus) transcriptome.

Acta Virol 2020 ;64(1):28-35

In this study, we identified the genome sequence of the novel virus Pistacia-associated flexivirus 1 (PAFV1), a putative member of the mycovirus family Gammaflexiviridae (the order Tymovirales), via analysis of a transcriptome dataset for the mastic tree (Pistacia lentiscus, the family Anacardiaceae). PAFV1 was predicted to have three open reading frames (ORFs): ORF1, encoding a replicase (REP) with RNA-dependent RNA polymerase activity; ORF2, a movement protein (MP); and ORF3, a hypothetical protein. The PAFV1 REP sequence showed high similarity to those of three known members of the family Gammaflexiviridae i. Read More

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http://dx.doi.org/10.4149/av_2020_104DOI Listing
January 2020

The investigation of hepatitis A virus and hepatitis E virus co-infection in humans and animals in China.

Acta Virol 2020 ;64(1):20-27

The aim of this study was to investigate the prevalence of co-infection of hepatitis A and hepatitis E virus (HAV/HEV) in patients with acute hepatitis as well as in different animal species. A total of 46 serum samples from patients diagnosed as hepatitis A or hepatitis E and 675 fecal samples of 11 animal species were collected. The IgM class antibodies to HEV and HAV, respectively, were detected by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.4149/av_2020_103DOI Listing
January 2020

Andrias davidianus ranavirus 1R encoding a delayed-early protein promotes cell proliferation by driving cell cycle progression into S phase.

Authors:
N T Yu F Ke Q Y Zhang

Acta Virol 2020 ;64(1):10-19

Andrias davidianus ranavirus 1R (ADRV-1R), a core gene of the family Iridoviridae, is predicted to encode a viral transcription factor (vTF) since the protein contains a virus late transcription factor-3 like (VLTF3 like) domain. However, its characteristics and function are still unclear. In this study, the transcription and expression of ADRV-1R were investigated in Chinese giant salamander thymus cells (GSTCs). Read More

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http://dx.doi.org/10.4149/av_2020_102DOI Listing
January 2020

HIV-1: towards understanding the nature and quantifying the latent reservoir.

Acta Virol 2020 ;64(1):3-9

The human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) pandemic constitutes one of the greatest public health issues, since 36.9 million people worldwide were living with HIV in 2017 and 940,000 died from AIDS- related illnesses in the same year. One of the main obstacles in the effort to achieve viral eradication or long-term virologic remission is the existence of the HIV-reservoir. Read More

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http://dx.doi.org/10.4149/av_2020_101DOI Listing
January 2020

Efficient inhibition of foot-and-mouth disease virus replication in vitro by artificial microRNA targeting 3D polymerase.

Acta Virol 2019 ;63(4):475-479

Foot-and-mouth disease (FMD) is a devastating acute viral disease of livestock with cloven hooves. Among various therapeutic control measures, RNA interference (RNAi) is one of the methods being explored to inhibit FMD virus replication and spread. The RNAi is achieved by short hairpin RNAs or artificial microRNAs (amiRNAs). Read More

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http://dx.doi.org/10.4149/av_2019_407DOI Listing
December 2019
5 Reads

Phosphorylation of nucleopolyhedrovirus 39K is essential for the regulation of viral gene transcription in silkworm cells.

Acta Virol 2019 ;63(4):469-474

39K protein was proven to be the most notable hyperphosphorylated protein of Bombyx mori nucleopolyhedrovirus (BmNPV), since its amino acid 136 has the highest phosphorylation ratio (16.683) among all of BmNPV phosphorylated proteins (Shobahah et al., 2017). Read More

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http://dx.doi.org/10.4149/av_2019_414DOI Listing
December 2019

Genetic variation and phylogenetic analysis of Porcine circovirus type 2 in China from 2016 to 2018.

Acta Virol 2019 ;63(4):459-468

Infection with Porcine circovirus type 2 (PCV2), the essential cause of porcine circovirus (PCV) associated diseases, is a growing problem in swine industry around the world. High nucleotide alteration leads to the constant evolution of PCV2 and outbreak of disease caused by PCV2. In this study, 48 PCV2 strains were isolated in China between 2016 and 2018 and the genetic diversity of these PCV2 isolates was determined. Read More

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http://dx.doi.org/10.4149/av_2019_413DOI Listing
December 2019

Kinetic analysis of bacteriophage Sf6 binding to outer membrane protein a using whole virions.

Acta Virol 2019 ;63(4):450-458

For successful infection, viruses must recognize their respective host cells. A common mechanism of host recognition by viruses is to utilize a portion of the host cell as a receptor. Bacteriophage Sf6, which infects Shigella flexneri, uses lipopolysaccharide as a primary receptor and then requires interaction with a secondary receptor, a role that can be fulfilled by either outer membrane proteins (Omp) A or C. Read More

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http://dx.doi.org/10.4149/av_2019_412DOI Listing
December 2019
4 Reads

Recombinant luciferase-expressing murine gammaherpesvirus 68 as a tool for rapid antiviral screening.

Acta Virol 2019 ;63(4):439-449

Murine gammaherpesvirus 68 (MHV-68) provides a valuable tool to screen novel therapeutic strategies against oncogenic gammaherpesviruses. The development and characterization of antiviral agents usually depend on appropriate screening assays. The aim of this study was to develop rapid and sensitive method for testing antiviral compounds against gammaherpesviruses. Read More

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http://dx.doi.org/10.4149/av_2019_411DOI Listing
December 2019

Genomic and phylogenetic characterization of a bunya-like virus from the freshwater Chinese mitten crab Eriocheir sinensis.

Acta Virol 2019 ;63(4):433-438

The freshwater Chinese mitten crab (Eriocheir sinensis), an indigenous crustacean in China, has been cultured for more than 30 years. It was reported that the bunya-like virus from Eriocheir sinensis (EsBV) was associated with the tremor disease (TD), which causes high mortality and has a serious impact on production. In this study, full-length genome sequences of EsBV were pursued using next generation sequencing; the genome of EsBV was found to be composed of 6. Read More

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http://dx.doi.org/10.4149/av_2019_410DOI Listing
December 2019

Proteomics analysis of suckling mouse brain infected with attenuated rabies virus strain SRV9.

Acta Virol 2019 ;63(4):423-432

Rabies virus is an enveloped negative-stranded RNA virus belonging to the family Rhabdoviridae. It can be successfully controlled by vaccination however, there are still tens of thousands of deaths each year caused by rabies virus due to its mutations and complexity. A better understanding of the interaction between the rabies virus and the host might help solve this problem. Read More

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http://dx.doi.org/10.4149/av_2019_406DOI Listing
December 2019

Identification of the experimental herbaceous host range of the Apscaviroids infecting citrus species.

Acta Virol 2019 ;63(4):415-422

Citrus viroid V (CVd-V), citrus dwarfing viroid (CDVd) and citrus bent leaf viroid (CBLVd) (the genus Apscaviroid, the family Pospiviroidae) have been reported to be restricted to citrus species naturally. The herbaceous host range of these viroids was identified using the viroids infectious clones. Several herbaceous plants from the Cucurbitaceae, Solanaceae, Fabaceae and Asteraceae families were found to be susceptible to CVd-V, CDVd and CBLVd. Read More

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http://dx.doi.org/10.4149/av_2019_405DOI Listing
December 2019

Attenuation and amino acid changes in infectious bronchitis virus Iranian 793/B serotype during serial passaging in embryonated chicken eggs.

Acta Virol 2019 ;63(4):403-414

The use of live attenuated vaccine (LAV) is the main method for controlling infectious bronchitis (IB). It is advisable to develop a LAV using a dominant serotype in the region in the case of vaccine failure. Since 793/B serotype is one of the most predominant circulating IB viruses in Iran, attenuation of three Iranian 793/B isolates (IR/773/2001, IR/794/2002 and IR/520/2002) was done by serial passaging in specific pathogen free (SPF) embryonated chicken eggs up to 90 passages to assess the degree of their attenuation to achieve a native LAV in the future. Read More

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http://dx.doi.org/10.4149/av_2019_404DOI Listing
December 2019

Autophagy triggered by MAVS inhibits Coxsackievirus A16 replication.

Acta Virol 2019 ;63(4):392-402

Mitochondrial antiviral signaling protein (MAVS), a crucial adaptor protein localized on mitochondria, plays vital roles in various biological processes. Autophagy and apoptosis are two independent and closely linked cell death pathways. But whether MAVS could induce apoptosis and autophagy in rhabdomyosarcoma cells (RD cells) and what is the relationship between autophagy and apoptosis still remains elusive. Read More

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http://dx.doi.org/10.4149/av_2019_403DOI Listing
December 2019
5 Reads

Molecular detection of Marek's disease virus in feather and blood samples from young laying hens in Colombia.

Acta Virol 2019 ;63(4):380-391

Marek's disease virus (MDV) is an immunosuppressive pathogen that can cause low production efficiency and high mortality rates in chickens. There is no current information on the MDV serotypes and pathotypes circulating in vaccinated commercial farms in Colombia where the birds are vaccinated in the incubator with Gallid herpesvirus (GaHV-2) and Meleagrid herpesvirus 1 (MeHV-1). Based on that, the main focus of this study was to understand the MDV's infection dynamics for the three known serotypes and to detect wild-virus pathogenic strains in 4-layer poultry farms in Antioquia. Read More

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http://dx.doi.org/10.4149/av_2019_402DOI Listing
December 2019

Identification of a novel member of the family Betaflexiviridae from the hallucinogenic plant Salvia divinorum.

Authors:
C J Goh Y Hahn

Acta Virol 2019 ;63(4):373-379

Betaflexiviridae is a family of plant-infecting RNA viruses with 11 recognized genera, of which genomes have diverse organization with three to six open reading frames (ORFs). A genome sequence of a novel Betaflexiviridae species, named Salvia divinorum RNA virus 1 (SdRV1), was identified in Salvia divinorum, herbal mint plant with hallucinogenic properties. The SdRV1 genome was predicted to have four ORFs encoding a replicase polyprotein (REP), a movement protein (MP), a coat protein (CP), and a putative nucleic acid-binding protein (NBP). Read More

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http://dx.doi.org/10.4149/av_2019_401DOI Listing
December 2019

Zostera virus T - a novel virus of the genus Tepovirus identified in the eelgrass, Zostera muelleri.

Acta Virol 2019 ;63(4):366-372

Analysis of a transcriptome dataset obtained from tissue samples of the eelgrass Zostera muelleri, an aquatic flowering plant species of the family Zosteraceae, yielded three genome sequence contigs of a novel RNA virus. Sequence comparison and phylogenetic analysis revealed that the novel RNA virus, named Zostera virus T (ZoVT), belongs to the genus Tepovirus of the family Betaflexiviridae. The three genome contigs of ZoVT showed 88. Read More

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http://dx.doi.org/10.4149/av_2019_409DOI Listing
December 2019

Different mechanisms of the protection against influenza A infection mediated by broadly reactive HA2-specific antibodies.

Acta Virol 2019 ;63(4):347-365

Influenza A viruses (IAVs) cause yearly repeating infections in humans. The current vaccination approach is based on the production of virus-neutralizing antibodies. Virus-neutralizing antibodies, however, are closely strain-specific due to the IAV variability. Read More

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http://dx.doi.org/10.4149/av_2019_408DOI Listing
December 2019

A case of intracranial molluscum contagiosum virus infection diagnosed by metagenomic sequencing of cerebrospinal fluid.

Acta Virol 2019 ;63(3):333-337

Molluscum contagiosum is a common, self-limiting infectious disease of the skin caused by molluscum contagiosum virus (MCV). The disease primarily affects children, sexually active adults, and immunocompromised individuals. Transmission of the virus occurs by direct skin contact. Read More

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http://dx.doi.org/10.4149/av_2019_313DOI Listing
September 2019
2 Reads

High prevalence of norovirus GII.P16/GII.2 and chicken anemia virus in two acute gastroenteritis outbreaks in Huzhou, China.

Acta Virol 2019 ;63(3):328-332

Acute gastroenteritis (AGE) is one of the most frequently occuring illnesses in children and adults worldwide. In February 2017, two AGE outbreaks occurred in two adjacent schools in Huzhou city, Zhenjiang province of China. We detected high percentages of recombinant norovirus GII. Read More

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http://dx.doi.org/10.4149/av_2019_312DOI Listing
September 2019
2 Reads

Epstein-Barr virus latent membrane protein 1 (LMP1) regulates the aldehyde dehydrogenase (ALDH) positive cell population in nasopharyngeal carcinoma cell lines.

Authors:
J Wu H Su G Li Y Huang

Acta Virol 2019 ;63(3):322-327

Nasopharyngeal carcinoma (NPC) is one of the severe head and neck carcinomas, which are rare in western countries but with high incidence in Southern Asia especially South China. NPC is relatively sensitive to radiotherapy, but the prognosis of patients in late stage is poor. The development of NPC is closely related to genetic background, Epstein-Barr virus (EBV) infection and life style. Read More

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http://dx.doi.org/10.4149/av_2019_308DOI Listing
September 2019

Extract prepared from the leaves of Ocimum basilicum inhibits the entry of Zika virus.

Acta Virol 2019 ;63(3):316-321

The recent Zika virus (ZIKV) outbreaks and rapid spread in tropical Latin America since introduction to Brazil in 2014, and now appearing cases in the USA, are alarming. World Health Organization (WHO) has considered transmission of ZIKV, a serious public health problem because of the increasing number of outbreaks. There are currently no drugs approved for the treatment of ZIKV infection. Read More

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http://dx.doi.org/10.4149/av_2019_307DOI Listing
September 2019

Growth activation of influenza virus by trypsin and effect of T-705 (favipiravir) on trypsin-optimized growth condition.

Acta Virol 2019 ;63(3):309-315

Influenza virus is activated by proteolytic cleavage of hemagglutinin by trypsin. After determining the optimal trypsin concentration, intracellular and extracellular influenza A/PR/8/34 (H1N1) and A/Victoria/361/2011 (H3N2) virus productions were compared in cultures treated with T-705 (favipiravir) and GS 4071 (an active form of oseltamivir). Although both drugs efficiently inhibited extracellular viral RNA release in a dose-dependent manner, T-705 inhibited it to the level of the inoculum without trypsin treatment, while GS 4071 inhibited it to a final level 10 times higher than that without trypsin. Read More

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http://dx.doi.org/10.4149/av_2019_311DOI Listing
September 2019
2 Reads

Efficacy and immunogenicity of a live L. acidophilus expressing SAD epitope of transmissible gastroenteritis virus as an oral vaccine.

Acta Virol 2019 ;63(3):301-308

Transmissible gastroenteritis virus (TGEV) causes great economic loss to swine industry worldwide. Vaccination is an important method to control the TGEV infection. In this study, a TGEV oral vaccine was generated by transferring a eukaryotic expression recombinant plasmid carrying the SAD (A and D antigenic sites of the S protein) epitope of TGEV into a swine-origin Lactobacillus acidophilus (L. Read More

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http://dx.doi.org/10.4149/av_2019_310DOI Listing
September 2019
1 Read

Secondary dengue infection in immunocompetent murine model leads to heart tissue damage.

Acta Virol 2019 ;63(3):292-300

Dengue, considered the most important arthropod-borne viral disease affecting humans, is transmitted by the bite of mosquitoes of the genus Aedes and caused by one of the four distinct serotypes of dengue virus (DENV-1, -2, -3 and -4). Infection with one of the four serotypes provides lifelong homotypic immunity. However, immunity against the heterologous serotypes is transient. Read More

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http://dx.doi.org/10.4149/av_2019_309DOI Listing
September 2019
1 Read

Schmallenberg virus affects T-bet, Gata3, RoRrγt, Foxp3 and Eomes in mice brain.

Authors:
E Aksoy A K Azkur

Acta Virol 2019 ;63(3):286-291

Schmallenberg virus (SBV), a neurotropic member of the genus Orthobunyavirus, infects ruminants and causes neurological lesions and fetal malformations including cerebellar hypoplasia, hydranencephaly, and porencephaly. The aim of this study is to establish intracerebral (i.c. Read More

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http://dx.doi.org/10.4149/av_2019_306DOI Listing
September 2019

Synthetic peptide optimization improves the inhibition of dengue NS2B-NS3 protease and dengue replication in vitro.

Acta Virol 2019 ;63(3):278-285

Dengue virus (DENV) infection is one of the most widely-spread flavivirus infections with no effective antiviral drugs available. Peptide inhibitors have been considered as one of the best drug candidates due to their high specificity, selectivity in their interactions and minimum side effects. In this study, we employed computational studies using YASARA, HADDOCK server and PyMOL software to generate short and linear peptides based on a reference peptide, CP5-46A, to block DENV NS2B-NS3 protease. Read More

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http://dx.doi.org/10.4149/av_2019_305DOI Listing
September 2019

Identification and phylogenetic analysis of an orf virus strain isolated in Anhui Province, East-central China, in 2018.

Acta Virol 2019 ;63(3):270-277

Orf, also called contagious ecthyma or contagious pustular dermatitis, is a significant zoonotic disease that primarily affects goat and sheep globally. Currently, the infection by orf virus (ORFV) has been observed in different host species worldwide, including China. Here, a suspected outbreak of orf infection in a goat farm in Anhui Province in 2018 was investigated. Read More

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http://dx.doi.org/10.4149/av_2019_304DOI Listing
September 2019
2 Reads

The effect of human interferon alpha on replication of different bovine viral diarrhea virus strains.

Acta Virol 2019 ;63(3):261-269

Bovine viral diarrhea virus (BVDV) exists in two main biotypes: cytopathic (cp) and noncytopathic (ncp). Although some studies were done on the effect of interferon alpha (IFN-α) on BVDV, the effect of exogenous IFN against BVDV biotypes remains unclear. In the present study, we evaluated the comparative effect of exogenous human IFN-α (HuIFN-α) on different BVDV biotypes and genotypes. Read More

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http://dx.doi.org/10.4149/av_2019_303DOI Listing
September 2019

The involvement of the substance P/neurokinin 1 receptor system in viral infection: focus on the gp120 fusion protein and homologous dipeptide domains.

Acta Virol 2019 ;63(3):253-260

The human immunodeficiency virus (HIV) envelope, via a key extracellular amino acid sequence, may simulate the functionality of native undecapeptide substance P (SP) acting through the host's neurokinin 1 (SP preferring) receptor (NK-1R). Human monocytes and macrophages express both NK-1Rs and SP. In HIV/AIDS the NK-1R may function as a chemokine-like G-protein coupled co-receptor that: 1) fuses to the outer envelope of HIV; 2) enables intracellular entry of the envelope-capsid-NK-1R complex; 3) co-opts immune defence via its physiological interaction with the SP-like envelope; 4) may contribute to resistance of CD4/chemokine entry inhibitor type drugs; 5) relaxes the blood-brain barrier to support entry of the HIV into the central nervous system, and 6) mediates most of the common clinical sequelae of HIV/AIDS (encephalopathy and AIDS dementia complex). Read More

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http://dx.doi.org/10.4149/av_2019_302DOI Listing
September 2019
2 Reads

Role of oral vaccines as an edible tool to prevent infectious diseases.

Acta Virol 2019 ;63(3):245-252

Plants have been as medicinal mediators for centuries. Recent trends in agro-biotechnology however, improved the therapeutic roles of plants to a significant level and introduced plant-based oral vaccine which can arouse an immune response in consumer. Although conventional vaccines against infectious diseases have been administrated for years the discovery of plant-based oral vaccines can potentially replace them completely in the future. Read More

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http://dx.doi.org/10.4149/av_2019_301DOI Listing
September 2019

Impact of interplay between autophagy and interferon-alpha in HCV and HCV/HIV infection.

Acta Virol 2019 ;63(2):235-239

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are among the most dangerous pathogens globally. Infection with HCV has been reported in a high percentage of HIV patients. Viruses are obligate intracellular pathogens and their survival is associated with their capability to subvert antiviral defenses of cells and to improve cellular processes required for their replication. Read More

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http://dx.doi.org/10.4149/av_2019_214DOI Listing
August 2019
5 Reads

Country-wide distribution of bluetongue virus with expanding host spectrum and evidence of vector competence in Hungary.

Acta Virol 2019 ;63(2):229-234

Following the introduction of bluetongue virus type 4 (BTV-4) in 2014, country-wide monitoring of bluetongue (BT) disease was performed to see whether the virus has become enzootic in Hungary. To analyse the epizootiology of BT, over 110,000 samples collected from domestic and wild ruminants were screened for the presence of BTV RNA and virus-specific antibodies using real-time RT-PCR assay and commercial ELISA kit, respectively. During laboratory analysis, specimens collected from 333 (0. Read More

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http://dx.doi.org/10.4149/av_2019_213DOI Listing
August 2019
6 Reads

Sequence analysis and biological characterization of virulent Avian avulavirus 1 isolated from asymptomatic migratory fowl.

Acta Virol 2019 ;63(2):223-228

Continuous monitoring and surveillance of avian avulaviruses (AAvVs) in water/migratory fowl is imperative to ascertain the evolutionary dynamics of these viruses. Here, we report genomic and amino acid characteristics of two AAvVs strains isolated from asymptomatic waterfowl (Anas carolinensis). Sequence characteristics including the presence of virulent motif (112RRQKR↓F117) and biological assessment confirmed the virulent nature of study isolates. Read More

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http://dx.doi.org/10.4149/av_2019_208DOI Listing
August 2019
12 Reads

Characterization and full genome sequencing of a velogenic Newcastle disease virus (NDV) strain Ck/IR/Beh/2011 belonging to subgenotype VII(L).

Acta Virol 2019 ;63(2):217-222

Avian avulavirus 1, better known as Newcastle disease virus (NDV), causes substantial loss to the poultry industry in many developing countries. In this study we have characterized and fully sequenced the genome of a velogenic NDV strain named Beh (Ck/IR/Beh/2011) that has been used in our lab for a number of challenge and immunological studies over the last few years. This strain was isolated from poultry in the city of Behshahr, Mazandaran Province, Iran after an outbreak reported in the region in 2011. Read More

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http://dx.doi.org/10.4149/av_2019_206DOI Listing
August 2019
7 Reads

A novel Waikavirus (the family Secoviridae) genome sequence identified in rapeseed (Brassica napus).

Authors:
D Park Y Hahn

Acta Virol 2019 ;63(2):211-216

The genome sequence of a novel species of the genus Waikavirus (the family Secoviridae), which we named Brassica napus RNA virus 1 (BnRV1), was identified in a rapeseed (Brassica napus) transcriptome dataset. The BnRV1 genome was 12,293 nucleotides long followed by a poly(A) tail. Two open reading frames (ORFs), called ORF1 and ORFX, were predicted. Read More

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http://dx.doi.org/10.4149/av_2019_205DOI Listing
August 2019
20 Reads

Comparative studies of mucosal humoral and cellular immune responses to 2009 pandemic H1N1 influenza virus in mice.

Acta Virol 2019 ;63(2):203-210

The nasal-associated lymphoid tissues (NALTs), embedded in the submucosa of murine upper respiratory tract, represents an important site of induction for local mucosal immune responses to airborne pathogens and intranasal vaccines. Here, we systematically investigated the mucosal humoral and cellular immune responses of NALTs in mice infected with A/Beijing/501/2009 (BJ501) and A/Puerto Rico/8/1934 (PR8) viruses. Compared with PR8 infection, BJ501 induced a more rapid increase of virus-specific IgA and IgG antibodies in the nasal lavage fluid and a higher ratio of IgG1/IgG2a, indicating a stronger Th2 response to BJ501 in mucosal immunity. Read More

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http://dx.doi.org/10.4149/av_2019_212DOI Listing
August 2019
15 Reads

Phylogenetic analysis of HA and NA genes of influenza H1N1 viruses from 1918 to 2017.

Acta Virol 2019 ;63(2):195-202

The 1918 "Spanish" pandemic is the earliest known influenza H1N1 virus. Since then H1N1 viruses circulated between humans and animals continuously. With the increased amount of samples of H1N1 viruses and technology development, researchers have been studying how the viruses evolved. Read More

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http://dx.doi.org/10.4149/av_2019_211DOI Listing
August 2019
19 Reads