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    770 results match your criteria Acta Reumatologica Portuguesa [Journal]

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    Adherence to the recommended prevention strategies before and after a hip fragility fracture: what makes us go blind?
    Acta Reumatol Port 2018 May 24. Epub 2018 May 24.
    Centro Hospitalar e Universitário de Coimbra.
    Objectives: Our main objective was to evaluate the percentage of patients under anti-osteoporotic treatment (OT) at the time of hip fracture (HF) and one and four years after the HF event. We compared these results with the percentage of patients who should be under treatment at all three stages, according to the recently published Portuguese cost-effectiveness recommendations (PCER) for OT. Data regarding occurrence of new fragility fractures and mortality were also determined, one and four years after the HF event. Read More

    Monocyte chemoattractant protein-1 promoter-2518 G allele increases renal damage in systemic lupus erythematosus patients: result from a meta-analysis.
    Acta Reumatol Port 2018 Apr 27. Epub 2018 Apr 27.
    Objective: Reports about the monocyte chemoattractant protein-1 (MCP-1) promoter-2518A/G polymorphism and systemic lupus erythematosus (SLE) were controversial. This study aimed to assess the association between MCP-1 promoter-2518A/G polymorphism and SLE via meta-analysis.

    Methods: Eligible studies were identified by searching the PubMed database for studies published before September 2015. Read More

    Identification of Key Genes and Pathways in Rheumatoid Arthritis Gene Expression Profile by Bioinformatics.
    Acta Reumatol Port 2018 Apr 16. Epub 2018 Apr 16.
    Objective: The aim of this study was to identify potential key candidate genes and uncover their potential mechanisms in rheumatoid arthritis.

    Materials And Methods: The gene expression profiles of GSE12021, GSE55457, GSE55584 and GSE55235 were downloaded from the gene expression omnibus database, including 45 rheumatoid arthritis and 29 normal samples. The differentially expressed genes between the two types of samples were identified with the Linear Models for Microarray Analysis package using R language. Read More

    Sonographic evaluation of salivary glands in juvenile Sjögren's syndrome.
    Acta Reumatol Port 2018 Jan-Mar;43(1):61-65
    Pontíficia Universidade Católica de Campinas.
    IIntroduction: Sjögren's syndrome in childhood is a rare autoimmune disease and mostly under-diagnosed. The aim of this study is to highlight the importance of ultrasonographic assessment of the salivary glands in children with recurrent parotitis and positive autoantibodies. Two cases of ultrasonographic patterns typical of Sjögren's syndrome have been described below. Read More

    The impact of patient global assessment in the definition of remission as a predictor of long-term radiographic damage in patients with rheumatoid arthritis: protocol for an individual patient data meta-analysis.
    Acta Reumatol Port 2018 Jan-Mar;43(1):52-60
    Centro Hospitalar e Universitário de Coimbra EPE.
    Background: Remission is the target for management of rheumatoid arthritis (RA) and intensification of immunosuppressive therapy is recommended for those that do not achieve this status. Patient global assessment (PGA) is the single patient reported outcome considered in the American College of Rheumatology/European League Against Rheumatism remission criteria, but its use as target has been questioned. The primary aim of this study is to assess whether excluding PGA from the definition of disease remission changes the association of disease remission with long-term radiographic damage and physical function in patients with RA. Read More

    Portuguese recommendations for the prevention, diagnosis and management of primary osteoporosis - 2018 update.
    Acta Reumatol Port 2018 Jan-Mar;43(1):10-31
    Background: Advances in osteoporosis (OP)case definition, treatment options, optimal therapy duration and pharmacoeconomic evidence in the national context motivated the Portuguese Society of Rheumatology (SPR) to update the Portuguese recommendations for the diagnosis and management of osteoporosis published in 2007.

    Methods: SPR bone diseases' working group organized meetings involving 55 participants (rheumatologists, rheumatology fellows and one OP specialist nurse) to debate and develop the document. First, the working group selected 11 pertinent clinical questions for the diagnosis and management of osteoporosis in standard clinical practice. Read More

    Cross-cultural adaptation and validation of the Portuguese version of the Oxford Shoulder Score (OSS).
    Acta Reumatol Port 2018 Mar 8. Epub 2018 Mar 8.
    University of Coimbra, Faculty of Economics, Coimbra, Portugal.
    Objective: To translate and culturally adapt the Oxford Shoulder Score (OSS) to the European Portuguese language, and to test its reliability (internal consistency, reproducibility and measurement error) and validity (construct validity).

    Methods: The OSS Portuguese version was obtained through translations, back-translations, consensus panels, clinical review and cognitive pre-test. Portuguese OSS, Disabilities of the Arm, Shoulder and Hand (DASH) questionnaires, and the visual analogue scales of pain at rest [VAS rest] and during movement [VAS movement] were applied to 111 subjects with shoulder pain (degenerative or inflammatory disorders) and recommended for physical therapy. Read More

    Effectiveness of a Referral Program for rheumatoid arthritis and axial spondyloarthritis Diagnosis at Primary Care Centers in Portugal - SIARA STUDY.
    Acta Reumatol Port 2018 Jan-Mar;43(1):40-51
    Objectives: Early diagnosis and treatment of Rheumatoid Arthritis (RA) and axial Spondylarthritis (axial SpA) can limit the impact of disease outcomes. This study evaluated the effectiveness of a referral program on the identification of patients with RA and axial SpA.

    Methods: This was an observational, prospective, randomized (by clusters) study conducted in Portugal to evaluate the impact of the implementation of a set of referral support actions (RSA). Read More

    Validation of Oral Health Impact Profile-14 and its association with Hypossialia in a Sjögren Syndrome Portuguese Population.
    Acta Reumatol Port 2018 Mar 5. Epub 2018 Mar 5.
    Aims: The objective of this study was to perform the Portuguese transcultural adaptation of the original Brazilian version of the Oral Health Impact Profile-14 (OHIP-14) while evaluating the association between hyposalivation and quality of life in a Sjögren´s Syndrome population.

    Methods: The original Brazilian version of the Oral Health Impact Profile-14 was culturally adapted following the guidelines for cross-cultural adaptation of health-related quality of life measures. The questionnaires were administered by trained and calibrated dental doctors to 86 patients with Sjögren´s Syndrome. Read More

    The importance of quality of life for work outcomes in patients with ankylosing spondylitis - a cross-sectional study.
    Acta Reumatol Port 2017 Oct-Dec;42(4):300-309
    Hacettepe Medical School.
    Aims: Work impairment is one of the most important exploration and one of the aims of rheumatologists. We aimed to determine the risk factors for employment state and predictive factors of work outcomes using multi-dimensional measures in patients with ankylosing spondylitis (AS) in this comprehensive study.

    Methods: One hundred patients with AS (31 females and 69 males) were included into this study. Read More

    Effectiveness of early adalimumab therapy in psoriatic arthritis patients from - EARLY PsA.
    Acta Reumatol Port 2017 Oct-Dec;42(4):287-299
    Hospital Garcia de Orta.
    Objective To compare outcomes in psoriatic arthritis (PsA) patients initiating adalimumab (ADA), with short- and long-term disease duration and to evaluate the potential effect of concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARD) or glucocorticoids. Methods Analyses included adult PsA patients registered in the Rheumatic Diseases Portuguese Register ( between June 2008-June 2016 who received ADA for ≥3 months. Read More

    Extra-articular manifestations and burden of disease in patients with radiographic and non-radiographic axial spondyloarthritis.
    Acta Reumatol Port 2018 Jan-Mar;43(1):32-39
    Medical Park Gaziosmanpasa Hospital, Gaziosmanpasa, Istanbul.
    Objective: Although the prevalence of peripheral and extra-articular disease in ankylosing spondylitis (AS) has been assessed in many studies, data on non-radiographic axial spondyloarthritis (nr-axSpA) is scanty. The aim of this study was first, to compare radiographic-axSpA/AS (r-axSpA/AS) and nr-axSpA concerning peripheral arthritis and extra-articular manifestations (EAMs), and second, to assess potential differences between patient subgroups with or without EAMs regarding disease burden.

    Methods: Data was extracted from our single center axSpA database. Read More

    Neonatal lupus - case series of a tertiary hospital.
    Acta Reumatol Port 2017 Oct-Dec;42(4):318-323
    Centro Hospitalar de São João, Porto.
    Neonatal lupus (NL) is a very rare condition with an estimated incidence of 1 in 20.000 pregnancies. It is caused by the transplacental passage of autoantibodies anti-Ro/SSA, antiSa/SSB antibodies and/or anti-U1 RNP antibodies into the fetal circulation. Read More

    Shoulder giant schwannoma - a diagnosis to be considered in painless shoulder masses.
    Acta Reumatol Port 2017 Oct-Dec;42(4):332-333
    Centro Hospitalar do Baixo Vouga, E.P.E.
    Tumours formed from peripheral nerve sheaths are rare in the shoulder. We present the case of a 80-year-old female referred to an orthopaedic surgery clinic because of a large painless mass of the right shoulder, with one year of evolution. There was no history of trauma, involvement of any other joint or systemic complaints. Read More

    Patients with newly diagnosed rheumatoid arthritis are at increased risk of diabetes mellitus: an observational cohort study.
    Acta Reumatol Port 2017 Oct-Dec;42(4):310-317
    Odense University Hospital, Svendborg Hospital.
    Aims: To reveal the prevalence of Diabetes Mellitus (DM) in patients with newly diagnosed Rheumatoid Arthritis (RA) and evaluate the association between clinical characteristics of RA and DM as well as treatment response in newly diagnosed RA patients with DM.

    Methods: Newly diagnosed, adult, RA patients, who were registered in Danish Danbio since 1st January 2010, were included. Patients' demographics, serology results including rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP) and antinuclear antibody (ANA) as well as disease activity score in 28 joints-C-reactive protein (DAS28-CRP) at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danbio Registry. Read More contribution to the knowledge of immune-mediated systemic rheumatic diseases.
    Acta Reumatol Port 2017 Jul-Sep;42(3):232-239
    Centro Hospitalar Baixo Vouga.
    Patient registries are key instruments aimed at a better understanding of the natural history of diseases, at assessing the effectiveness of therapeutic interventions, as well as identifying rare events or outcomes that are not captured in clinical trials. However, the potential of registries goes far beyond these aspects. For example, registries promote the standardization of clinical practice, can also provide information on domains that are not routinely collected in clinical practice and can support decision-making. Read More

    Erythema elevatum diutinum in Crohn's disease-associated Spondyloarthritis - a rare vasculitis, an unusual association.
    Acta Reumatol Port 2017 Oct-Dec;42(4):324-328
    Erythema elevatum diutinum is a rare neutrophilic dermatoses with vasculitis, which presents as persistent, symmetrical, purple or brownish papules and nodules, mainly in the extensor surface of the limbs. We describe a case of erythema elevatum diutinum and polyarthritis as initial manifestations of Crohn's disease associated spondyloarthritis. A 51-year-old man, from São Tomé e Príncipe, with previous history of treated tuberculosis and chronic hepatitis B infection, was admitted due to 4 months history of polyarthritis, hyperpigmented papules on the extensor surfaces, occasional episodes of bloody mucous diarrhea and significant weight loss. Read More

    The Portuguese Society of Rheumatology position paper on the use of biosimilars - 2017 update.
    Acta Reumatol Port 2017 Jul-Sep;42(3):219-228
    Biosimilars are new and more affordable similar versions of previously approved reference biological drugs. Following the approval of the first monoclonal antibody biosimilar in 2013, the Portuguese Society of Rheumatology issued a position paper on the use of biosimilars in rheumatic conditions covering efficacy, safety, extrapolation, interchangeability, substitution and pharmacovigilance. However, as this is a rapidly evolving field, it was felt that the knowledge and evidence gathered since then justified an update of these statements. Read More

    Portuguese recommendations for the use of biological therapies in patients with axial spondyloarthritis - 2016 update.
    Acta Reumatol Port 2017 Jul-Sep;42(3):209-218
    Rheumatology and Metabolic Bone Diseases Department, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon Academic Medical Centre, Lisbon, P.
    Objective: To update the recommendations for the treatment of axial spondyloarthritis (axSpA) with biological therapies, endorsed by the Portuguese Society of Rheumatology.

    Methods: These treatment recommendations were formulated by Portuguese rheumatologists based on literature evidence and consensus opinion. At a national meeting, the 7 recommendations included in this document were discussed and updated. Read More

    Translation and cross-cultural adaptation of the ASAS Health Index and ASAS Environmental Factors Item Set into European Portuguese Language.
    Acta Reumatol Port 2017 Jul-Sep;42(3):256-262
    CEDOC; NOVA Medical School| Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa; Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, Lisboa.
    Objective: There is a lack of outcome measures to assess the impact of axial spondyloarthritis (axSpA) on health, function and quality of life. The Assessment of SpondyloArthritis International Society (ASAS) group developed the ASAS Health Index (ASAS-HI) and the ASAS Environmental Factors Item Set (ASAS-EF) to measure functioning and health across all aspects of health that are typically affected and relevant for patients with axSpA, based on the International Classification of Functioning, Disability and Health (ICF). The aim of this paper was to describe the translation and cross-cultural adaptation of both questionnaires into European Portuguese among patients with radiographic and non-radiographic axial SpA (nr-axSpA) and test the conceptual equivalence of the translated version in the Portuguese context. Read More

    Axial involvement according to ASAS criteria in an observational psoriatic arthritis cohort.
    Acta Reumatol Port 2017 Apr-Jun;42(2):176-182
    The definition of axial involvement in psoriatic arthritis (PsA) is still under debate. Currently, the axial spondyloarthritis (SpA) criteria defined by Assessment of Spondyloarthritis International Society (ASAS) may be the most adequate.(1) The aims of present study were to assess axial involvement according to ASAS criteria in an observational PsA cohort and define the clinical characteristics more associated with this kind of involvement. Read More

    Anticentromere antibody positive Ackerman's Syndrome with Granulomatous Anterior Uveitis.
    Acta Reumatol Port 2017 Jul-Sep;42(3):277-278
    Instituto Português de Reumatologia.
    Ackerman's Syndrome or Intersticial Granulomatous Dermatitis with Arthritis has been an issue of increasing number of reports in the last decade which had focused its heterogeneous cutaneous and rheumatologic expression besides the initial manifestations reported by Ackerman and his group. Granulomatosis anterior uveitis has not been previously described. Some patients are reported to have positive autoantibodies but association with anticentromere antibodies has not been previously described as well, to our knowledge. Read More

    Radiculopathy in a patient with chronic tophaceus gout: vertebral imaging.
    Acta Reumatol Port 2017 Jul-Sep;42(3):269-270
    Instituto Portguês de Reumatologia.
    Introduction: Spinal involvement is infrequent in chronic gout. However, some cases of back pain with radiculopathy secondary to this etiology have been reported.

    Case Report: 56-year old male patient, with history of arterial hypertension, hypertriglyceridemia, obesity, glucose intolerance and alcohol abuse, diagnosed with gout in his fifth decade of life. Read More

    Portuguese recommendations for the use of methotrexate in rheumatic diseases - 2016 update.
    Acta Reumatol Port 2017 Apr-Jun;42(2):127-140
    on behalf of the Portuguese Society of Rheumatology.
    Background: Methotrexate (MTX) is the first-line drug in the treatment of rheumatoid arthritis (RA) and the most commonly prescribed disease modifying anti-rheumatic drug. Moreover, it is also used as an adjuvant drug in patients under biologic therapies, enhancing the efficacy of biologic agents.

    Objectives: To review the literature and update the Portuguese recommendations for the use of MTX in rheumatic diseases first published in 2009. Read More

    Systemic sclerosis induced by interferon-alfa treatment of melanoma.
    Acta Reumatol Port 2017 Jul-Sep;42(3):263-264
    Systemic sclerosis is a connective tissue disease characterized by a complex pathogenesis and a multi organ involvement of unknown etiology. Genetic features and environmental factors, as the use of some drugs, influence the onset of the clinical picture. The authors describe a case of a patient who developed systemic sclerosis after treatment of melanoma with interferon alfa-2b, drug rarely implicated in the induction of this disease. Read More

    Polymorphism rs2275913 of Interleukin-17A is related to more intensive therapy with disease-modifying anti rheumatic drugs in Mexican patients with Rheumatoid Arthritis.
    Acta Reumatol Port 2017 Apr-Jun;42(2):155-161
    Escuela Superior de Medicina, Instituto Politécnico Nacional.
    Aim: The study has two aims: 1) to evaluate the association of IL-17 polymorphism rs2275913 with RA severity and 2) to evaluate if this particular SNP is associated with susceptibility for RA in Mexican patients.

    Methods: Seventy-six RA patients and ninety-four healthy controls were included in the study. RA patients were evaluated according to DAS 28. Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis in childhood-onset systemic lupus erythematosus patients: a multicenter study.
    Acta Reumatol Port 2017 Jul-Sep;42(3):250-255
    Universidade Federal de São Paulo (UNIFESP).
    Objective: To assess Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a large population of childhood-onset systemic lupus erythematosus (cSLE) patients.

    Methods: Multicenter study including 852 cSLE patients followed in Pediatric Rheumatology centers in São Paulo, Brazil. SJS was defined as epidermal detachment below 10% of body surface area (BSA), overlap SJS-TEN 10-30% and TEN greater than 30% of BSA. Read More

    Lupus protein-losing enteropathy patient with protein C and protein S deficiency-induced thrombosis: A case report with review of the literature.
    Acta Reumatol Port 2017 Jul-Sep;42(3):265-268
    Faculty of Medicine; Thammasat University.

    A case report of SLE with PLE in an Asian female; presented with edema, pleural effusion, ascites and profound hypoalbuminemia. She also had severe protein C and protein S depletion from GI loss which caused extensive thrombosis. Her disease was refractory to the treatment with high dose steroid, azathioprine, mycophenolate mofetil and cyclophosphamide. Read More

    CD13/aminopeptidase N mRNA expression and enzyme activity in Systemic Lupus Erythematosus.
    Acta Reumatol Port 2017 Apr-Jun;42(2):162-167
    Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Aims: To determine the significance of CD13/aminopeptidase N (APN) in systemic Lupus Erythromatus (SLE), we examined its catalytic activity and mRNA expression level in sera and peripheral whole blood cells of patients with SLE.

    Methods: In this study, 47 SLE patients and 44 age, sex matched healthy controls were included. The SLE disease activity index score and clinical finding including renal involvement and blood pressure were recorded. Read More

    Risk factors for late deep infection after total hip arthroplasty in patients with rheumatoid arthritis.
    Acta Reumatol Port 2017 Apr-Jun;42(2):150-154
    Kobe University Graduate School of Medicine.
    Objective: Postoperative infections, a serious complication of orthopedic surgery, occur 2-4 times more frequently in patients with rheumatoid arthritis (RA) without adjustment for medication. Some studies have demonstrated a similar risk of postoperative infection following orthopedic surgery regardless of whether patients underwent tumor necrosis factor-α (TNF-α) inhibitor therapy; however, other studies have reported a higher risk with TNF-α inhibitor use. However, few reports have focused on the correlation between TNF-α inhibitor use and postoperative late infection. Read More

    Primary Breast Lymphoma with cutaneous involvement in a patient with Rheumatoid Arthritis - a complication of infliximab therapy?
    Acta Reumatol Port 2017 Apr-Jun;42(2):191-195
    Centro Hospitalar e Universitário de Coimbra.
    It is well established that rheumatoid arthritis is associated with an increased risk of lymphoma. The use of tumor-necrosis factor-α inhibitors as a therapy in rheumatoid arthritis has been related to higher incidence of lymphoma arising at atypical and/or unusual locations; however, recent data shows their safety. We report the case of a 79 year-old woman with rheumatoid arthritis treated with infliximab, who presented a primary breast lymphoma with cutaneous involvement. Read More

    UVA1 for diffuse cutaneous systemic sclerosis in a Fitzpatrick skin type VI patient: outcomes in the modified Rodnan skin score.
    Acta Reumatol Port 2017 06;42(2)(Apr-Jun):196-197
    Centro Hospitalar e Universitário de Coimbra.
    Introduction: Cutaneous sclerosis can lead to important mobility impairment. Ultraviolet (UV) A1 phototherapy may improve skin sclerosis, although most of the studies have been with Caucasian patients.

    Material And Methods: A 44-year-old patient, Fitzpatrick skin type VI, was being followed up with the diagnosis of diffuse cutaneous systemic sclerosis. Read More

    Real-life effectiveness of Golimumab in biologic-naïve patients with rheumatoid arthritis - data from the Rheumatic Diseases Portuguese Register (
    Acta Reumatol Port 2017 06;42(Apr-Jun):141-149
    Faculdade de Ciências Médicas da Universidade Nova de Lisboa.
    Objectives: To assess the effectiveness of subcutaneous Golimumab 50 mg/monthly combined with methotrexate (SC GLM + MTX) over 52 weeks of treatment, in biologic-naïve RA patients, in a multicentre nationwide cohort from the Rheumatic Diseases Portuguese Register (

    Methods: Data for this observational study was collected from March 2011 to August 2015. Read More

    Interventions aiming to reduce early retirement due to rheumatic diseases.
    Acta Reumatol Port 2017 Jul-Sep;42(3):240-248
    NOVA Medical School, Universidade Nova de Lisboa (NMS/UNL), Lisboa, Portugal.
    Introduction: Aging of the population and early retirement translates into productivity losses to society. Persistence of working life is crucial to counteract this sustainability issue faced by western countries. Musculoskeletal and rheumatic diseases (RD) may cause work disability and early exit from work, including early retirement. Read More

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