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Acta Psychiatr Scand 2022 May 20. Epub 2022 May 20.

Global Brain Health Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland.

Objective: Little is known about the economic value of clinical interventions for delirium. This review aims to synthesise and appraise available economic evidence, including resource use, costs, and cost-effectiveness of interventions for reducing, preventing, and treating delirium.

Methods: Systematic review of published and grey literature on full and partial economic evaluations. Read More

Acta Psychiatr Scand 2022 May 18. Epub 2022 May 18.

Department of Psychosis, Institute of Mental Health, Singapore.

Acta Psychiatr Scand 2022 May 18. Epub 2022 May 18.

Instituto de Investigación Sanitaria (IDIS) de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Galicia, Spain.

Objective: To test whether a schizophrenia polygenic risk score (PRS) based on the subset of polymorphisms that affect brain expression of genes with altered expression by antipsychotics (exprAP PRS) is associated with psychiatric readmission of patients with schizophrenia.

Methods: The study involved 427 patients with schizophrenia. Genes with altered expression by antipsychotics were extracted from the Comparative Toxigenomics Database. Read More

Acta Psychiatr Scand 2022 May 16. Epub 2022 May 16.

Department of Affective Disorders, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.

Acta Psychiatr Scand 2022 May 10. Epub 2022 May 10.

Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.

Acta Psychiatr Scand 2022 May 3. Epub 2022 May 3.

School of Psychology, Ulster University, Coleraine, UK.

Objective: The prevalence, construct validity, risk factors and psychopathological correlates associated with ICD-11 posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) as measured by the International Trauma Questionnaire for Children and Adolescents (ITQ-CA) were assessed in a sample of young people from Northern Ireland.

Method: Participants were trauma-exposed 11-19-year-olds (N = 507) who participated in the Northern Ireland Youth Wellbeing Prevalence Survey (YWS-NI, 2020). Factor mixture modelling (FMM) was used to test the latent structure of the ITQ-CA. Read More

Acta Psychiatr Scand 2022 Apr 29. Epub 2022 Apr 29.

Department of Psychiatry, Sunnybrook Health Sciences Centre and the University of Toronto, Toronto, ON, Canada.

Objective: To determine if there is an association between antenatal hypnotic benzodiazepine receptor agonist exposure and congenital malformations or other adverse pregnancy outcomes in the offspring.

Methods: Databases were searched to January 31, 2021. Cohort studies published in English on congenital malformations or other adverse pregnancy outcomes in infants following exposure compared to those unexposed, were summarized and meta-analyzed where possible. Read More

Acta Psychiatr Scand 2022 Apr 18. Epub 2022 Apr 18.

Department: University Center of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Objectives: Polypharmacy and late-life depression often congregate in the geriatric population. The primary objective is to identify determinants of polypharmacy in patients with depression, and second to examine polypharmacy in relation to various clinical phenotypes of depression and its course.

Methods: A longitudinal observational study using data of the Netherlands Study of Depression in Older persons (NESDO) including 375 patients with depression 60 years and 132 non-depressed comparisons. Read More

Acta Psychiatr Scand 2022 Apr 15. Epub 2022 Apr 15.

University of Utah, Department of Psychiatry, Salt Lake City, USA.

Objectives: Previous research suggests that cognitive performance worsens during manic and depressed states in bipolar disorder (BD). However, studies have often relied upon between-subject, cross-sectional analyses and smaller sample sizes. The current study examined the relationship between mood symptoms and cognition in a within-subject, longitudinal study with a large sample. Read More

Acta Psychiatr Scand 2022 Apr 15. Epub 2022 Apr 15.

Assertive Community Treatment Team "ETAC Área VII", Servicio Murciano de Salud, Murcia, Spain.

Acta Psychiatr Scand 2022 Jun 20;145(6):541-543. Epub 2022 Apr 20.

Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

Acta Psychiatr Scand 2022 Apr 13. Epub 2022 Apr 13.

Center for Neuropsychiatric Schizophrenia Research & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.

Objective: Historically, assessment of the psychometric properties of the Positive and Negative Syndrome Scale (PANSS) has had several foci: (1) calculation of reliability indexes, (2) extraction of subdimensions from the scale, and (3) assessment of the validity of the total score. In this study, we aimed to examine the scalability and to assess the clinical performance of the 30-item PANSS total score as well as the scalability of a shorter version (PANSS-6) of the scale.

Methods: A composite data set of 1073 patients with first-episode schizophrenia or schizophrenia spectrum disorder was subjected to Rasch analysis of PANSS data from baseline and 4-6 weeks follow-up. Read More

Acta Psychiatr Scand 2022 May;145(5):421-422

Department of Pharmacy, Maudsley Hospital, London, UK.

Acta Psychiatr Scand 2022 Apr 6. Epub 2022 Apr 6.

Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Acta Psychiatr Scand 2022 Mar 31. Epub 2022 Mar 31.

INCLIVA - Biomedical Research Institute, Valencia, Spain.

Objective: Obesity and metabolic diseases such as metabolic syndrome (MetS) are more prevalent in people with type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). MetS components might be associated with neurocognitive and functional impairments in these individuals. The predictive and discriminatory validity of MetS and its components regarding those outcomes were assessed from prospective and transdiagnostic perspectives. Read More

Acta Psychiatr Scand 2022 Mar 30. Epub 2022 Mar 30.

Interventional Psychiatry Program, Mental Health and Addictions Service, St. Michael's Hospital, Toronto, Ontario, Canada.

Objective: To systematically review published research studies and ongoing clinical trials investigating nitrous oxide (N O) in psychiatric disorders, providing an up-to-date snapshot of the clinical research landscape.

Methods: A comprehensive literature search was conducted for studies published until June 2021 using the OVID databases (MEDLINE, Embase, APA PsycInfo) and the clinical trial registries (ClinicalTrials.gov, ICTRP). Read More

Acta Psychiatr Scand 2022 Mar 24. Epub 2022 Mar 24.

Department of Community Mental Health, Mental Health Service Noord-Holland Noord, Alkmaar, The Netherlands.

Objective: To investigate the safety of COVID-19 vaccination in patients on clozapine as regards plasma clozapine concentration and haematological parameters.

Methods: We conducted a multicentre observational cohort study from 22 February 2021 to 2 September 2021. Primary outcomes were clinically relevant increase in clozapine blood levels (>100 μg/L increase compared to baseline) and clozapine alert levels (>1000 μg/L). Read More

Acta Psychiatr Scand 2022 Mar 24. Epub 2022 Mar 24.

Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital Bochum, Ruhr University, Bochum, Germany.

Objective: Research on coercion in mental healthcare has recently shifted to the investigation of subjective aspects, both on the side of the people with mental disorders affected and the staff members involved. In this context, the role of personality traits and attitudes of staff members in decision-making around coercion is increasingly being assessed. This study aimed to examine the role of staff attitudes towards coercion and staff members' personality traits in decision-making around coercion in an experimental setting. Read More

Acta Psychiatr Scand 2022 Jun 1;145(6):557-567. Epub 2022 Apr 1.

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Objective: To investigate the association between mirtazapine exposure in pregnancy and risk of specific adverse pregnancy outcomes.

Methods: A register-based nationwide cohort study was conducted including all registered pregnancies in Denmark from 1997 to 2016. Mirtazapine-exposed pregnancies were compared with mirtazapine unexposed pregnancies in a 1:4 ratio matched according to propensity scores. Read More

Acta Psychiatr Scand 2022 Jun 24;145(6):578-590. Epub 2022 Mar 24.

Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Objective: To investigate whether child mental health problems prospectively associate with IQ-achievement discrepancy (i.e., academic under- and over-achievement) in emerging adolescence. Read More

Acta Psychiatr Scand 2022 Jun 13;145(6):628-639. Epub 2022 Mar 13.

University of Connecticut Medical School Psychiatry Department, Farmington, Connecticut, USA.

Objective: Developmental trauma disorder (DTD) is a childhood psychiatric syndrome designed to include sequelae of trauma exposure not fully captured by PTSD. This study aimed to determine whether the assessment of DTD with an independent sample of children in mental health treatment will replicate results from an initial validation study.

Methods: The DTD semi-structured interview (DTD-SI) was administered to a convenience sample in six sites in the United States (N = 271 children in mental health care, 8-18 years old, 47% female, 41% Black or Latinx) with measures of trauma history, DSM-IV PTSD, probable DSM-IV psychiatric diagnoses, emotion regulation/dysregulation, internalizing/externalizing problems, and quality of life. Read More

Acta Psychiatr Scand 2022 May 16;145(5):507-516. Epub 2022 Mar 16.

Center for Life Course Health Research, University of Oulu, Oulu, Finland.

Objective: Psychiatric disorders have been implied as both risk factors and prodromal symptoms of Alzheimer's disease (AD). A better understanding of the history of psychiatric morbidity in people with AD may aid with understanding this relationship and highlight challenges in diagnosing AD in people with concomitant psychiatric disorders.

Methods: Medication use and Alzheimer's disease (MEDALZ) study is a nationwide register-based cohort of people (n = 70,718) who received a clinically verified AD diagnosis in Finland in 2005-2011 and were community-dwelling at the time of diagnosis. Read More

Acta Psychiatr Scand 2022 04;145(4):317-318

Institute of Clinical Medicine, National Centre for Suicide Research and Prevention, University of Oslo, Oslo, Norway.

Acta Psychiatr Scand 2022 04;145(4):416-418

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, London, UK.

Acta Psychiatr Scand 2022 04;145(4):412-415

Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.

Acta Psychiatr Scand 2022 Mar 6. Epub 2022 Mar 6.

Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan.

Objective: A previous cross-sectional study reported that nighttime light is associated with increased occurrence of manic symptoms in bipolar disorder; however, the longitudinal association between nighttime light and subsequent mood episode relapses remains unclear. We determined whether bedroom nighttime light was associated with mood episode relapses in patients with bipolar disorder.

Methods: This prospective cohort study included 172 outpatients with bipolar disorder who participated in an Association between the Pathology of Bipolar Disorder and Light Exposure in Daily Life (APPLE) cohort study. Read More

Acta Psychiatr Scand 2022 Jun 11;145(6):615-627. Epub 2022 Mar 11.

Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA.

Background: Childhood trauma affects the course of mood disorders. Researchers are now considering childhood trauma as an influential factor in the treatment of mood disorders. However, the role of childhood trauma in the treatment of bipolar disorder remains understudied. Read More

Acta Psychiatr Scand 2022 May 16;145(5):494-506. Epub 2022 Mar 16.

Department of Psychology, University of Georgia, Athens, Georgia, USA.

Objective: Difficulties in social cognition are common in individuals with schizophrenia (SZ) and are not ameliorated by antipsychotic treatment. Intranasal oxytocin (OT) administration has been explored as a potential intervention to improve social cognition; however, results are inconsistent, suggesting potential individual difference variables that may influence treatment response. Less is known about the relationship between endogenous OT and social cognition in SZ, knowledge of which may improve the development of OT-focused therapies. Read More

Acta Psychiatr Scand 2022 Jun 10;145(6):591-603. Epub 2022 Mar 10.

Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Background: Childhood trauma is associated with greater depression severity among individuals with bipolar disorder. However, the mechanisms that explain the link between childhood trauma and depression severity in bipolar disorder remain poorly understood. The mediational role of attachment insecurity in childhood and adulthood was assessed in the current study. Read More