707,103 results match your criteria Acta Polytechnica Hungarica[Journal]

The role of matrix stiffness in cancer stromal cell fate and targeting therapeutic strategies.

Acta Biomater 2022 Aug 7. Epub 2022 Aug 7.

The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, China; Key laboratory of biotherapy and regenerative medicine, The first hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China; Department of general surgery, The first hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, China. Electronic address:

The tumor microenvironment (TME) is a complex macromolecular network filled with a series of stromal cells. It plays an important role in tumorigenesis, development, immune escape, drug resistance, and other processes and has received increasing attention in recent years. Currently, tumor cell-centered treatments are insufficient to eradicate malignancies, and researchers are constantly searching for better treatments. Read More

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Single-injection COVID-19 subunit vaccine elicits potent immune responses.

Acta Biomater 2022 Aug 7. Epub 2022 Aug 7.

Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China; School of Chemistry, Tiangong University, Tianjin 300387, China. Electronic address:

Current vaccination schedules, including COVID-19 vaccines, require multiple doses to be administered. Single injection vaccines eliciting equivalent immune response are highly desirable. Unfortunately because unconventional release kinetics are difficult to achieve it still remains a huge challenge. Read More

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Protein-Based Polymer Liquid Embolics for Cerebral Aneurysms.

Acta Biomater 2022 Aug 7. Epub 2022 Aug 7.

Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, Utah, USA; TheraTarget, Inc., Salt Lake City, Utah, USA; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA. Electronic address:

Cerebral aneurysms (CA), an abnormal bulge in the arteries that supply blood to the brain, are prone to rupture and can cause hemorrhagic stroke. Physicians can treat CA by blocking blood flow to the aneurysmal sac via clipping of the aneurysm neck via open procedure, or endovascular occlusion of the aneurysm with embolic materials to promote thrombus formation to prevent further inflow of blood into the aneurysm. Endovascular treatment options for CA still have significant limitations in terms of safety, usability in coagulopathic patients, and risks of device migration. Read More

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A Carrier-free, Dual-Functional Hydrogel Constructed of Antimicrobial Peptide Jelleine-1 and 8Br-cAMP for MRSA Infected Diabetic Wound Healing.

Acta Biomater 2022 Aug 7. Epub 2022 Aug 7.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Research Unit of Peptide Science, Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, West Donggang Road 199, Lanzhou, 730000, P. R. China; State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, P. R. China. Electronic address:

Bacterial infection and local growth factor deficiency are two of the major causes of the nonunion of diabetic wounds. Antimicrobial peptides (AMPs) are believed to be alternatives to antibiotics against drug-resistant bacterial infections. 8-Bromoadenosine-3', 5'-cyclic monophosphate (8Br-cAMP) can promote cells to secrete growth factors and accelerate cell proliferation. Read More

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Chagas Disease in northern Chile: detection of Trypanosoma cruzi in children, dogs and triatomine bugs.

Acta Trop 2022 Aug 7:106631. Epub 2022 Aug 7.

Laboratorio de Entomología, Subdepartamento de Genética Molecular, Instituto de Salud Pública de Chile, Santiago, Chile.

Chagas disease is an anthropozoonotic disease caused by the protozoan Trypanosoma cruzi, transmitted by triatomine vectors. In Chile, there are four species of triatomine bugs that are potential vectors of T. cruzi, being Triatoma infestans the main vector in endemic areas of the country. Read More

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Physical mechanism on linear spectrum and nonlinear spectrum in double helical carbon nanomolecule-infinitene.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jul 27;282:121674. Epub 2022 Jul 27.

College of Science, Liaoning Petrochemical University, Fushun 113001, China. Electronic address:

In this work, based on density functional theory (DFT) and wave function analysis, the properties of absorption spectrum, electronic circular dichroism (ECD) spectrum and Raman spectrum of infinitene (monomer and dimer) with double helical structure are theoretically studied. The electronic excitation properties of infinitene were investigated based on the visualization method charge density difference (CDD) and transition density matrix (TDM). It is found that there is obvious intermolecular charge transfer behavior in the dimer. Read More

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Junctional complexes of the blood-testis barrier in the Japanese quail (Coturnix Coturnix japonica).

Acta Histochem 2022 Aug 7;124(7):151929. Epub 2022 Aug 7.

Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Private bag X04, Onderstepoort, Pretoria 0110, South Africa.

This study investigated the developmental changes in the adherens junctions, gap junctions, as well as tight junctions forming the blood-testis barrier (BTB) in Japanese quail (Coturnix Coturnix japonica) testis. Testicular tissue from pre-pubertal, pubertal, adult, and aged Japanese quail were examined by immunohistochemistry and transmission electron microscopy (TEM). The tight junction proteins claudin-3, claudin-11, occludin and zonula occludens-1 (ZO-1), were generally localised in the cytoplasm of Sertoli cells, spermatogonia, and spermatocytes of pre-pubertal, pubertal, some adult birds. Read More

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Relationship between body awareness level and musculoskeletal pain complaints, physical activity level and emotional status in healthy people.

Acta Neurol Belg 2022 Aug 10. Epub 2022 Aug 10.

Department of Anatomy, Faculty of Medicine, Çanakkale Onsekiz Mart University, 61040, Çanakkale, Turkey.

INTRODUCTıON/AIM: Defining the physical, psycho-social effects of body awareness may help to explain the functional effects. It was aimed to examine the relationship between the body awareness level and musculoskeletal pain complaints, physical activity level, and emotional state in healthy people.

Materials And Methods: A total of 289 healthy individuals between the ages of 18 and 25 were included in the study. Read More

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Carbon [email protected] metal-organic frameworks hybrids for ratiometric fluorescent determination of pesticide thiophanate-methyl.

Mikrochim Acta 2022 Aug 10;189(9):325. Epub 2022 Aug 10.

College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, People's Republic of China.

A dual-emission fluorescent (FL) probe was constructed by coordinating Cu of copper metal-organic frameworks (Cu-MOFs) with - COO group of carbon dots (CDs) for pesticide thiophanate-methyl (TM) determination. TM was recognized by organic ligands (HBDC and HBDC-NH) of Cu-MOFs via π stacking. Due to the higher affinity of Cu to TM than ligands and CDs, TM chelated with Cu to form TM-Cu complex. Read More

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Gut microbial products valerate and caproate predict renal outcome among the patients with biopsy-confirmed diabetic nephropathy.

Acta Diabetol 2022 Aug 10. Epub 2022 Aug 10.

Department of Nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, 41 Xibei Street, Ningbo, 315010, Zhejiang Province, People's Republic of China.

Aims: Valerate and caproate are two subtypes of short-chain fatty acids produced by gut microbiota. We aimed to measure the serum valerate and caproate levels and analyze the associations between them and renal prognosis of diabetic nephropathy (DN).

Methods: The serum samples of patients with biopsy-confirmed diagnosis of DN were collected in the First Affiliated Hospital of Zhejiang University, from April 1, 2013, to March 31, 2018. Read More

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Rainwater Charitable Foundation criteria for the neuropathologic diagnosis progressive supranuclear palsy.

Acta Neuropathol 2022 Aug 10. Epub 2022 Aug 10.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.

Neuropathologic criteria for progressive supranuclear palsy (PSP) proposed by a National Institute of Neurological Disorders and Stroke (NINDS) working group were published in 1994 and based on the presence of neurofibrillary tangles in basal ganglia and brainstem. These criteria did not stipulate detection methods or incorporate glial tau pathology. In this study, a group of 14 expert neuropathologists scored digital slides from 10 brain regions stained with hematoxylin and eosin (H&E) and phosphorylated tau (AT8) immunohistochemistry. Read More

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Simple electrocardiography algorithm for localizing accessory pathway in patients with Wolff-Parkinson-White syndrome.

Acta Cardiol 2022 Aug 10:1-5. Epub 2022 Aug 10.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Background: Existing algorithms to predict the location of an accessory pathway (AP) in Wolff-Parkinson-White Syndrome (WPW) have good sensitivity and specificity but complex with various accuracy and inter-observer agreement rates. A simple algorithm with high accuracy and inter-observer agreement rates is needed.

Methods: This was a cross-sectional and retrospective diagnostic study. Read More

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Clinical characteristics of heart failure patients with mid-range ejection fraction.

Acta Cardiol 2022 Aug 10:1-8. Epub 2022 Aug 10.

Research Group on Heart Failure, IIS Aragón, Zaragoza, Spain.

Background: We aimed to characterise and compare the clinical profile of heart failure (HF) with mid-range (HFmrEF), reduced (HFrEF) and preserved (HFpEF) left-ventricular ejection fraction.

Methods: We conducted a descriptive, observational study in 267 HF patients admitted to the Internal Medicine department of a tertiary hospital during 2010-2016. The study population was divided into three groups according to the ejection fraction rate: HFrEF (<40%), HFmrEF (40-49%), and HFpEF (≥50%). Read More

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Investigating the inflammatory status in the patients candidate for second angiography after coronary stent implantation.

Acta Cardiol 2022 Aug 10:1-6. Epub 2022 Aug 10.

Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

: Inflammation has been shown to be an important feature of atherosclerosis. We aimed to assess a profile of inflammatory cytokines and growth factors in patients with established coronary artery disease (CAD), 12 months after stent implantation.: A total of 193 patients with CAD, who were candidates for angiography, 12 months after stent implantation (cases), were compared with 107 patients with CAD, who were candidates for their first angiography (controls). Read More

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Keratitis fugax hereditaria: hiding in plain sight in Sweden?

Tero T Kivelä

Acta Ophthalmol 2022 Sep;100(6):603-604

Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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September 2022

Risk of obstetric anal sphincter injury associated with female genital mutilation/cutting and timing of deinfibulation.

Acta Obstet Gynecol Scand 2022 Aug 9. Epub 2022 Aug 9.

Norwegian Research Centre for Women's Health, Division of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway.

Introduction: A greater risk of obstetric anal sphincter injury has been reported among African migrants in several host countries compared with the general population. To what degree female genital mutilation/cutting affects this risk is not clear. In infibulated women, deinfibulation prevents anal sphincter injury. Read More

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Benefits of adrenal venous sampling with preoperative four-dimensional CT imaging.

Acta Radiol 2022 Aug 9:2841851221118799. Epub 2022 Aug 9.

Department of Radiological Sciences, Graduate School of Biomedical Sciences, 12961Nagasaki University, Nagasaki, Japan.

Background: The effects of adrenal venous sampling (AVS) may be limited by the anatomical variants of adrenal veins.

Purpose: To investigate the benefits of AVS for patients who underwent four-dimensional computed tomography (4D CT) before AVS.

Material And Methods: We reviewed the images of contrast-enhanced four phase three-dimensional (3D) and 4D CT in patients who received AVS between February 2010 and February 2021. Read More

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Corneal transplantation in aniridia-related keratopathy with a two-year follow-up period, an uncommon disease with precarious course.

Acta Ophthalmol 2022 Aug 9. Epub 2022 Aug 9.

Department of Clinical Sciences, Ophthalmology, Umeå University, Umeå, Sweden.

Purpose: The purpose of this study is to study the frequency, surgical transplantation technique and outcome in patients with aniridia-related keratopathy (ARK) with two-year follow-up period.

Methods: A retrospective registry-study including all ARK cases performed in Sweden and Denmark between 2001 and 2016 and registered in the Swedish Cornea Transplant Registry.

Results: A total of 36 eyes of 26 patients were subjected to corneal transplantation due to ARK during 2001 to 2016. Read More

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Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology.

Acta Neuropathol Commun 2022 Aug 9;10(1):111. Epub 2022 Aug 9.

Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University (NU) Feinberg School of Medicine, 300 E. Superior St., Tarry 8, Chicago, IL, 60611, USA.

Quantification of in vivo amyloid and tau PET imaging relationships with postmortem measurements are critical for validating the sensitivity and specificity imaging biomarkers across clinical phenotypes with Alzheimer disease neuropathologic change (ADNC). This study examined the quantitative relationship between regional binding of in vivo F-florbetapir amyloid PET and F-flortaucipir tau PET with postmortem stereological counts of amyloid plaques and neurofibrillary tangles (NFT) in a case of primary progressive aphasia (PPA) with ADNC, where neurodegeneration asymmetrically targets the left hemisphere. Beginning 2 years prior to death, a 63-year-old right-handed man presenting with agrammatic variant PPA underwent a florbetapir and flortaucpir PET scan, and neuropsychological assessments and magnetic resonance imaging sessions every 6 months. Read More

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Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.

Acta Neuropathol 2022 Aug 9. Epub 2022 Aug 9.

Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Gliomas arising in the setting of neurofibromatosis type 1 (NF1) are heterogeneous, occurring from childhood through adulthood, can be histologically low-grade or high-grade, and follow an indolent or aggressive clinical course. Comprehensive profiling of genetic alterations beyond NF1 inactivation and epigenetic classification of these tumors remain limited. Through next-generation sequencing, copy number analysis, and DNA methylation profiling of gliomas from 47 NF1 patients, we identified 2 molecular subgroups of NF1-associated gliomas. Read More

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The need to consider return to work as a main outcome in patients undergoing surgery for diffuse low-grade glioma: a systematic review.

Acta Neurochir (Wien) 2022 Aug 9. Epub 2022 Aug 9.

Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Agustin Fliche, 34295, Montpellier, France.

Objective: For a long time, return to work (RTW) has been neglected in patients harboring a diffuse low-grade glioma (LGG). However, a majority of LGG patients worked at time of diagnosis. Moreover, these patients now live longer given current treatment paradigms, especially thanks to early maximal surgery. Read More

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Diagnostic accuracy of DSA in carotid artery stenosis: a comparison between stenosis measured on carotid endarterectomy specimens and DSA in 644 cases.

Acta Neurochir (Wien) 2022 Aug 9. Epub 2022 Aug 9.

Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University in Prague and Military University Hospital Prague, U Vojenské nemocnice 1200/2, Prague 6, 16000, Czech Republic.

Background And Purpose: DSA (digital subtraction angiography) is the gold standard for measuring carotid artery stenosis (CS). Yet, the correlation between DSA and stenosis is not well documented.

Material And Methods: We compared CS as measured by DSA to carotid artery specimens obtained from carotid endarterectomy surgery. Read More

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Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes.

Acta Pharmacol Sin 2022 Aug 9. Epub 2022 Aug 9.

Medical Research Center, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

Abdominal aortic aneurysm (AAA) is a dangerous vascular disease without any effective drug therapies so far. Emerging evidence suggests the phenotypic differences in perivascular adipose tissue (PVAT) between regions of the aorta are implicated in the development of atherosclerosis evidenced by the abdominal aorta more vulnerable to atherosclerosis than the thoracic aorta in large animals and humans. The prevalence of thoracic aortic aneurysms (TAA) is much less than that of abdominal aortic aneurysms (AAA). Read More

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14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling.

Acta Pharmacol Sin 2022 Aug 9. Epub 2022 Aug 9.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Interleukin (IL)-1β is a culprit of adipose tissue inflammation, which in turn causes systematic inflammation and insulin resistance in obese individuals. IL-1β is mainly produced in monocytes and macrophages and marginally in adipocytes, through cleavage of the inactive pro-IL-1β precursor by caspase-1, which is activated via the NLRP3 inflammasome complex. The nuclear factor-κB (NF-κB) transcription factor is the master regulator of inflammatory responses. Read More

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NDM-1 Zn1-binding residue His116 plays critical roles in antibiotic hydrolysis.

Biochim Biophys Acta Proteins Proteom 2022 Aug 6:140833. Epub 2022 Aug 6.

The State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. Electronic address:

Bacteria carrying NDM-1 have been labeled as superbugs because it confers upon them resistance to a broad range of β-lactam antibiotics. The enzyme has a di‑zinc active centre, with the Zn2 site extensively studied. The roles of active-site Zn1 ligand residues are, however, still not fully understood. Read More

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Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell.

Biochim Biophys Acta Gen Subj 2022 Aug 6:130224. Epub 2022 Aug 6.

Department of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Background: Sodium taurocholate co-transportering polypeptide (NTCP, SLC10A1) is a vital bile acid transporter and the functional receptor of hepatitis B and D virus. The oligomerization of NTCP is important for the structural study of its interaction with HBV preS1 peptide.

Methods: Recombinant NTCPs were expressed in Sf9 host cell using baculoviruses. Read More

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Combined treatment of xyloglucan derivative hydrogel and anti-C5a receptor antibody in preventing peritoneal adhesion.

Acta Biomater 2022 Aug 6. Epub 2022 Aug 6.

School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China. Electronic address:

Postoperative peritoneal adhesion is a common complication after surgery with high morbidity. In addition to improving surgical operations, medical therapy and physical barriers are the two main ways to prevent postoperative peritoneal adhesion. Satisfactory efficacy is not often obtained by the single antiadhesion method, and the combination of barrier therapy and antiadhesion drugs has attracted more attention. Read More

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A novel rearrangement of the α-globin gene cluster containing both the -α and αααα crossover junctions in a Chinese family.

Clin Chim Acta 2022 Aug 6. Epub 2022 Aug 6.

Department of Clinical Laboratory, Yulin Women and Children Health Care Hospital, Yulin, Guangxi Zhuang Autonomous Region, China. Electronic address:

Background: Thalassemia is one of the most common hemoglobinopathies. Thalassemia is mainly caused by the loss and/or deficiency of one or more globin chains in hemoglobin. The copy number variant (CNV) of α-globin gene is one of the important factors affecting the clinical phenotype of β-thalassemia. Read More

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Molecular dynamics simulations of the human ocular lens with age and cataract.

Biochim Biophys Acta Biomembr 2022 Aug 6:184025. Epub 2022 Aug 6.

Department of Chemical and Biomolecular Engineering, College Park, MD 20742, USA; Biophysics Graduate Program, University of Maryland, College Park, MD 20742, USA. Electronic address:

The human ocular lens consists primarily of elongated, static fibers characterized by high stability and low turnover, which differ dramatically in their composition and properties from other biological membranes. Cholesterol (Chol) and sphingolipids (SL) are present at high concentrations, including saturated SLs, such as dihyrosphingomyelin (DHSM). Past molecular dynamics simulations demonstrated that the presence of DHSM and high Chol concentration contributes to higher order in lipid membranes. Read More

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Evolution of quinol oxidation within the heme‑copper oxidoreductase superfamily.

Biochim Biophys Acta Bioenerg 2022 Aug 6:148907. Epub 2022 Aug 6.

Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

The heme‑copper oxidoreductase (HCO) superfamily is a large superfamily of terminal respiratory enzymes that are widely distributed across the three domains of life. The superfamily includes biochemically diverse oxygen reductases and nitric oxide reductases that are pivotal in the pathways of aerobic respiration and denitrification. The adaptation of HCOs to use quinol as the electron donor instead of cytochrome c has significant implication for the respiratory flexibility and energetic efficiency of the respiratory chains that include them. Read More

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