692,292 results match your criteria Acta Polytechnica Hungarica[Journal]

Reversal of renal tissue hypoxia during experimental cardiopulmonary bypass in sheep by increased pump flow and arterial pressure.

Acta Physiol (Oxf) 2021 Apr 22;231(4):e13596. Epub 2020 Dec 22.

Pre-Clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.

Aim: Renal tissue hypoxia during cardiopulmonary bypass could contribute to the pathophysiology of acute kidney injury. We tested whether renal tissue hypoxia can be alleviated during cardiopulmonary bypass by the combined increase in target pump flow and mean arterial pressure.

Methods: Cardiopulmonary bypass was established in eight instrumented sheep under isoflurane anaesthesia, at a target continuous pump flow of 80 mL·kg min and mean arterial pressure of 65 mmHg. Read More

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Neonatal Resuscitation in the NICU; Challenges Beyond NRP.

Acta Paediatr 2021 Aug 4. Epub 2021 Aug 4.

Neonatal Intensive Care Unit, Lady Davis Carmel Medical Center, Haifa, Israel.

Resuscitation of neonates in the newborn period requires attention to cardiopulmonary health with a focus on ventilation and return of spontaneous circulation. Newborn resuscitation at delivery is performed according to the Neonatal Resuscitation Program (NRP) algorithm. Infants and children are resuscitated by Pediatric Advanced Life Support (PALS) guidelines from The American Heart Association (AHA). Read More

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Virus antibodies after SARS-CoV-2 infection.

Acta Paediatr 2021 Aug 4. Epub 2021 Aug 4.

Dr DY Patil University, Pune, India.

We would like to share our thoughts on the paper published recently in Acta Paediatrica that stated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies started to decline just four months after children became infected with the virus. Breuer et al also concluded that re-opening schools did not affect infection rates. The authors used the Abbott Architect SARS-CoV-2 IgG assay (manufacturer, region, country). Read More

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High glycaemic variability is associated with progression of COVID-19.

Acta Diabetol 2021 Aug 4. Epub 2021 Aug 4.

Diabetes Centre, Admiralty Medical Centre, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828, Singapore.

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Response to letter: "Stereotactic biopsies of brainstem lesions: dilemma on the best trajectory".

Acta Neurochir (Wien) 2021 Aug 4. Epub 2021 Aug 4.

Department of Neurosurgery, Inselspital, University Hospital Bern, and University of Bern, 3010, Bern, Switzerland.

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Response to: Some historical remarks on ipsilateral hemiparesis and the absence of decussation of the pyramidal tracts.

Acta Neurochir (Wien) 2021 Aug 4. Epub 2021 Aug 4.

Division of Neurosurgery, Department of Surgery, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada.

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Ultrasensitive electrochemical detection of hepatitis C virus core antigen using terminal deoxynucleotidyl transferase amplification coupled with DNA nanowires.

Mikrochim Acta 2021 Aug 3;188(8):285. Epub 2021 Aug 3.

Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400016, China.

Early diagnosis of hepatitis C virus (HCV) infection is essential to prevent disease from spreading and progression. Herein, a novel electrochemical biosensor was developed for ultrasensitive detection of HCV core antigen (HCVcAg) based on terminal deoxynucleotidyl transferase (TdT) amplification and DNA nanowires (DNW). After sandwich-type antibody-antigen recognition, the antibody-conjugated DNA was pulled to the electrode surface and further extended into a long DNA sequence by robust TdT reaction. Read More

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Evidence of disrupted rhombic lip development in the pathogenesis of Dandy-Walker malformation.

Acta Neuropathol 2021 Aug 4. Epub 2021 Aug 4.

Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, USA.

Dandy-Walker malformation (DWM) and Cerebellar vermis hypoplasia (CVH) are commonly recognized human cerebellar malformations diagnosed following ultrasound and antenatal or postnatal MRI. Specific radiological criteria are used to distinguish them, yet little is known about their differential developmental disease mechanisms. We acquired prenatal cases diagnosed as DWM and CVH and studied cerebellar morphobiometry followed by histological and immunohistochemical analyses. Read More

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Primary cutaneous indolent B-cell lymphomas - a retrospective multicenter analysis and a review of literature.

Acta Oncol 2021 Aug 4:1-8. Epub 2021 Aug 4.

Department of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wrocław Medical University, Wroclaw, Poland.

Primary cutaneous indolent B-cell lymphomas (PCBCLs) are not well characterized due to their rarity and indolent character. We retrospectively reviewed the data from 52 patients with primary cutaneous follicular lymphoma (PCFL) ( = 26), marginal zone lymphoma (PCMZL) ( = 25) or undefined PCBCL ( = 1) treated in 10 hematology centers in 1999-2019. In almost half of the patients, pruritus or pain were present at diagnosis. Read More

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Evaluation of the blood-perilymph barrier in ears with endolymphatic hydrops.

Acta Otolaryngol 2021 Aug 4:1-6. Epub 2021 Aug 4.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Otological diseases including Meniere's disease (MD) involve endolymphatic hydrops (EH), which can be visualized by magnetic resonance imaging (MRI) with gadolinium contrast agents, but the temporal changes of contrast in the inner ear have not been evaluated.

Objectives: We investigated the permeability of the blood-perilymph barrier (BPB) in ears with EH to evaluate the severity of the inner ear disturbances.

Materials And Methods: The study included 32 ears from 16 patients with EH or related diseases who underwent MRI. Read More

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Health perception by young adults born very preterm.

Acta Paediatr 2021 Aug 4. Epub 2021 Aug 4.

Department of Pediatrics, Sainte-Justine University Hospital Research Center, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.

Aim: This study assessed the self-reported health perception and use of healthcare by adults born very preterm before 30 weeks of gestation.

Methods: The participants were part of a cross-sectional observational study that assessed the global health of young adults aged 18-29 years born very preterm in Quebec, Canada. Health perception was explored from 2011-2016 using the second Short-Form 36 Health Survey (SF-36v2) and objective health measures were obtained. Read More

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Music Therapy for Preterm Neonates in the Neonatal Intensive Care Unit: An Overview of Systematic Reviews.

Acta Paediatr 2021 Aug 4. Epub 2021 Aug 4.

Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA, 77030.

Aim: To summarize the quantity and quality of evidence for using music therapy for preterm infants in the neonatal intensive care unit (NICU).

Methods: We performed an overview of evidence for the effectiveness and safety of MT for preterm infants in the NICU. We performed a random effects meta-analysis of data from studies that fit the definition of MT. Read More

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Effect of a nutritional supplementation on growth and body composition in short and lean preadolescent boys: a randomized, double-blind, placebo-controlled study.

Acta Paediatr 2021 Aug 4. Epub 2021 Aug 4.

The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Aim: evaluate the effect of nutritional supplementation on height, weight, and body composition in short and lean male preadolescents.

Methods: A randomized, double-blinded, placebo-controlled trial of nutritional supplementation of short and lean prepubertal 10-14.5-year-old boys. Read More

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High maternal blood lipid levels during early pregnancy are associated with increased risk of congenital heart disease in offspring.

Acta Obstet Gynecol Scand 2021 Aug 3. Epub 2021 Aug 3.

Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China.

Introduction: This study aimed to investigate whether maternal blood lipid levels during early pregnancy are associated with the occurrence of congenital heart disease (CHD) in their offspring.

Material And Methods: In this single-center case-control study, mothers of offspring with CHD (n = 230) and without CHD (n = 381) were included. Maternal lipid levels were determined on fasting blood samples taken in the first trimester. Read More

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Redescription and Molecular Characterization of Pachysentis canicola Meyer, 1931 (Acanthocephala: Oligacanthorhynchidae) from the Maned Wolf, Chrysocyon brachyurus (Illiger, 1815) in Texas.

Acta Parasitol 2021 Aug 3. Epub 2021 Aug 3.

Molecular Taxonomy Laboratory, Department of Zoology, Chaudhary Charan Singh University, Meerut, U.P., 250004, India.

Background: The original description of Pachysentis canicola Meyer, 1931 was based on an unknown number of specimens from an undetermined species of Canis in Brazil from the Berlin Museum. It has since been reported from other carnivores in South and North America. Our specimens from the maned wolf, Chrysocyon brachyurus (Illiger, 1815), in Texas, represent a new host record, and has shed more light on morphometric characteristics missing from the original description, and expanded the range of variations in characters that remained fixed since 1931 and that have been repeated in other taxonomic accounts. Read More

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Amplified electrochemical antibiotic aptasensing based on electrochemically deposited AuNPs coordinated with PEI-functionalized Fe-based metal-organic framework.

Mikrochim Acta 2021 Aug 4;188(8):286. Epub 2021 Aug 4.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, People's Republic of China.

A facile and versatile competitive electrochemical aptasensor for tobramycin (TOB) detection is described using electrochemical-deposited AuNPs coordinated with PEI-functionalized Fe-based metal-organic framework (AuNPs/P-MOF) as signal-amplification platform and a DNA probe labeled with methylene blue (MB) at the 3'-end (MB-Probe) as a signal producer. First, F-Probe (short complementary DNA strands of both the aptamer and the MB-Probe label with a sulfhydryl group at the 5'-end) was immobilized on the AuNPs/P-MOF modified electrode as detection probes, which competed with TOB in binding to the aptamer. TOB-aptamer binding resulted in F-Probe remaining unhybridized on the electrode surface, so that a significant current response was generated by hybridizing with MB-Probe instead. Read More

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Single-cell multimodal analysis in a case with reduced penetrance of Progranulin-Frontotemporal Dementia.

Acta Neuropathol Commun 2021 Aug 3;9(1):132. Epub 2021 Aug 3.

Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.

We identified an autosomal dominant progranulin mutation carrier without symptoms of dementia in her lifetime (Reduced Penetrance Mutation Carrier, RedPenMC). This resistance to develop expected pathology presents a unique opportunity to interrogate neurodegenerative mechanisms. We performed multimodal single-nuclei analyses of post-mortem frontal cortex from RedPenMC, including transcriptomics and global levels of chromatin marks. Read More

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Right temporal variant frontotemporal dementia is pathologically heterogeneous: a case-series and a systematic review.

Acta Neuropathol Commun 2021 Aug 3;9(1):131. Epub 2021 Aug 3.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.

Although the right temporal variant frontotemporal dementia (rtvFTD) is characterised by distinct clinical and radiological features, its underlying histopathology remains elusive. Being considered a right-sided variant of semantic variant primary progressive aphasia (svPPA), TDP-43 type C pathology has been linked to the syndrome, but this has not been studied in detail in large cohorts. In this case report and systematic review, we report the autopsy results of five subjects diagnosed with rtvFTD from our cohort and 44 single rtvFTD subjects from the literature. Read More

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Multigene Combined Detection by RT-qPCR Using Cytological Specimens.

Acta Cytol 2021 Aug 3:1-10. Epub 2021 Aug 3.

Department of Cytology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: The aim of the study was to investigate the mutation status of multiple driver genes by RT-qPCR and their significance in advanced lung adenocarcinoma using cytological specimens.

Materials And Methods: 155 cytological specimens that had been diagnosed with lung adenocarcinoma in the Fourth Hospital of Hebei Medical University were selected from April to November 2019. The cytological specimens included serous cavity effusion and fine-needle aspiration biopsies. Read More

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Photoinduced linkage isomers in a model ruthenium nitrosyl complex: Identification and assignment of vibrational modes.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 22;263:120217. Epub 2021 Jul 22.

Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Acad. Lavrentiev Avenue, Novosibirsk 630090, Russian Federation.

Photoinduced NO-linkage isomers were investigated in the solid state of labelled trans-[Ru(NO)(py)F](ClO) complex by combined IR-spectroscopy and DFT calculations. Based on the experimental data and the DFT calculations of this isotopically labelled NO nitrosyl compound, we present a complete assignment of the vibrational bands of three nitrosyl linkage isomers in a range from 4000 to 200 cm. The calculated IR-spectra match well with the experimental data allowing reliable assignment of the vibrational bands. Read More

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Label-free diagnosis of breast cancer based on serum protein purification assisted surface-enhanced Raman spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 28;263:120234. Epub 2021 Jul 28.

Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, Fujian, China; School of opto-electronic and Communication Engineering, Xiamen University of Technology, Xiamen, Fujian, China. Electronic address:

Serum protein is generally used to assess the severity of disease, as well as cancer progression and prognosis. Herein, a simple and rapid serum proteins analysis method combined with surface-enhanced Raman spectroscopy (SERS) technology was applied for breast cancer detection. The cellulose acetate membrane (CA) was employed to extract human serum proteins from 30 breast cancer patients and 45 healthy volunteers and then extracted proteins were mixed with silver nanoparticles for SERS measurement. Read More

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Cellular nanovesicles with bioorthogonal targeting enhance photodynamic/photothermal therapy in psoriasis.

Acta Biomater 2021 Jul 31. Epub 2021 Jul 31.

XuZhou Central Hospital, Xuzhou, 221009, PR China; Xuzhou Central Hospital Affiliated to Medical School of Southeast University, Xuzhou, 221009, PR China; XuZhou Clinical School of Xuzhou Medical University, Xuzhou, 221009, PR China. Electronic address:

The interaction between over-proliferating keratinocytes and excessive activated immune cells contributes to the development and progression of psoriasis. Photodynamic therapy (PDT)/photothermal therapy (PTT) is a promising method to treat skin diseases due to their synergistic effect and low side effect. Cell membrane is an ideal cell-mediated drug delivery platform with inherent biocompatibility, but lacks of specific targeting properties to increase drug accumulation in the psoriatic site. Read More

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Age-dependent mechanical and microstructural properties of the rabbit soleus muscle.

Acta Biomater 2021 Jul 31. Epub 2021 Jul 31.

Institute of Mechanics and Adaptronics, Technische Universität Braunschweig, Braunschweig D-38106, Germany. Electronic address:

During growth there are serious changes in the skeletal muscles to compensate for the changed requirements in terms of body weight and size. In this study, the age-dependent (between 21 and 100 days) mechanical and microstructural properties of rabbit soleus muscle tissue were investigated. For this purpose, morphological properties (animal mass, soleus muscle mass, tibial length) were measured at 5 different times during aging. Read More

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The N93D mutation of the human T-cell leukemia virus type -1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding.

Biochim Biophys Acta Proteins Proteom 2021 Jul 31:140708. Epub 2021 Jul 31.

Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan.

Human T-cell leukemia virus type 1 (HTLV-1) infection of host cells is mainly mediated by interactions with the viral envelope glycoprotein surface unit (SU) and three host receptors: heparan sulfate proteoglycan, neuropilin-1 (Nrp1), and glucose transporter type 1. Residues 90-94 of SU are considered as a Nrp1 binding site, and our previous results show that an SU peptide consisting of residues 85-94 can bind directly to the Nrp1 b1 domain with a binding affinity of 7.4 μM. Read More

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Nanobodies as powerful pulmonary targeted biotherapeutics against SARS-CoV-2, pharmaceutical point of view.

Biochim Biophys Acta Gen Subj 2021 Jul 31:129974. Epub 2021 Jul 31.

Department of Pharmaceutics, Faculty of pharmacy, Tehran University of Medical Sciences, Iran; Medical Biomaterial Research Center (MBRC), Tehran University of Medical Sciences, Iran. Electronic address:

Background Since December 2019, the newly emerged SARS-CoV-2 virus continues to infect humans and many people died from severe Covid-19 during the last 2 years worldwide. Different approaches are being used for treatment of this infection and its consequences, but limited results have been achieved and new therapeutics are still needed. One of the most interesting biotherapeutics in this era are Nanobodies which have shown very promising results in recent researches. Read More

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The role of actomyosin in the regulation of syndecan-1 in hyperosmosis.

Weiqi Li Wen Wang

Biochim Biophys Acta Gen Subj 2021 Jul 31:129975. Epub 2021 Jul 31.

Institute of Bioengineering and School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK. Electronic address:

Introduction: The endothelial glycocalyx is susceptible to high concentration of glucose and sodium in the blood. These challenges often involve an increase in osmotic pressure which may independently alters the glycocalyx components. The glycocalyx anchors on the cell membrane via core proteins that link with the actin cytoskeleton. Read More

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Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation.

Biochim Biophys Acta Mol Basis Dis 2021 Jul 31:166238. Epub 2021 Jul 31.

Department of Cell and Developmental Biology, Vanderbilt University; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center.

Chronic low-grade retinal inflammation is an essential contributor to the pathogenesis of diabetic retinopathy (DR). It is characterized by increased retinal cell expression and secretion of a variety of inflammatory cytokines; among these, IL-1β has the reputation of being a major driver of cytokine-induced inflammation. IL-1β and other cytokines drive inflammatory changes that cause damage to retinal cells, leading to the hallmark vascular lesions of DR; these include increased leukocyte adherence, vascular permeability, and capillary cell death. Read More

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Impact of maternal nutrition in viral infections during pregnancy.

Biochim Biophys Acta Mol Basis Dis 2021 Jul 31:166231. Epub 2021 Jul 31.

Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain; Epidemiología Clínica y Riesgo Cardiovascular, Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Sevilla, Spain.

Other than being a physiological process, pregnancy is a condition characterized by major adaptations of maternal endocrine and metabolic homeostasis that are necessary to accommodate the fetoplacental unit. Unfortunately, all these systemic, cellular, and molecular changes in maternal physiology also make the mother and the fetus more prone to adverse outcomes, including numerous alterations arising from viral infections. Common infections during pregnancy that have long been recognized as congenitally and perinatally transmissible to newborns include toxoplasmosis, rubella, cytomegalovirus, and herpes simplex viruses (originally coined as ToRCH infections). Read More

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Apoptosis regulation at the mitochondria membrane level.

Biochim Biophys Acta Biomembr 2021 Jul 31:183716. Epub 2021 Jul 31.

Institute for Genetics, CECAD Research Center, University of Cologne, Germany. Electronic address:

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis that activates the caspase cascade and irreversibly causes the majority of cells to die. The proteins of the Bcl-2 family are master regulators of apoptosis that form a complex interaction network within the mitochondrial membrane that determines the induction of MOMP. This culminates in the activation of the effector members Bax and Bak, which permeabilize the mitochondrial outer membrane to mediate MOMP. Read More

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The studies on the membrane activity of triester of phosphatidylcholine in artificial membrane systems.

Biochim Biophys Acta Biomembr 2021 Jul 31:183711. Epub 2021 Jul 31.

Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland. Electronic address:

Due to the increasing number of infections together with the appearance of bacteria exhibiting multi-drug resistance, new antibiotics are being sought. In this context the interest of the cationic lipoids increases because of their amphiphilic structure and positive charge that can stimulates the antibacterial action of these compounds. Thus, in this work we have performed the studies on the effect of one selected triesters of phosphatidylcholine, namely 1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (EDPPC), on the model lipid membranes. Read More

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