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Biochim Biophys Acta Mol Basis Dis 2022 Jun 27:166474. Epub 2022 Jun 27.

Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:

A high-fat diet (HFD) is a major risk factor for chronic kidney disease. Although HFD promotes renal injury, characterized by increased inflammation and oxidative stress leading to fibrosis, the underlying mechanism remains elusive. Here, we investigated the role and mechanism of protease-activating receptor 2 (PAR2) activation during HFD-induced renal injury in C57/BL6 mice. Read More

Biochim Biophys Acta Rev Cancer 2022 Jun 27:188754. Epub 2022 Jun 27.

Laboratory of Epigenetics, Institute of Medical Biology, Polish Academy of Sciences, 90-364 Lodz, Poland. Electronic address:

Melanoma is considered one of the most aggressive skin cancers. It spreads and metastasizes quickly and is intrinsically resistant to most conventional chemotherapeutics, thereby presenting a challenge to researchers and clinicians searching for effective therapeutic strategies to treat patients with melanoma. The use of inhibitors of mutated serine/threonine-protein kinase B-RAF (BRAF), e. Read More

Biochim Biophys Acta Bioenerg 2022 Jun 27:148586. Epub 2022 Jun 27.

Departamento de Bioquímica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México City, Mexico. Electronic address:

Plant mitochondria are sensitive organelles affected by changing environmental stressors. Upon heat shock or the presence of reactive oxygen species, plant mitochondria undergo in vivo morphological derangements associated with the extensively characterized opening of the mitochondrial permeability transition pore. Nevertheless, the classic mitochondrial permeability transition is known to be triggered by calcium overload causing mitochondrial swelling and dysfunction. Read More

Acta Histochem 2022 Jun 27;124(6):151919. Epub 2022 Jun 27.

Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Anhui 233030, China; Department of Life Sciences, Bengbu Medical College, Anhui 233030, China. Electronic address:

Pancreatic cancer is one of the deadliest cancers in the world, causing hundreds of thousands of deaths worldwide annually. Because of late diagnosis, rapid metastasis and drug resistance to chemotherapy, pancreatic cancer has a poor prognosis. Although the treatment of pancreatic cancer has made tremendous progress, the options for effective treatment are still limited, and new treatment methods are in crying needs to improve prognosis in clinic. Read More

Acta Psychol (Amst) 2022 Jun 27;228:103650. Epub 2022 Jun 27.

School of Management, University of Bath, United Kingdom. Electronic address:

The internet is often viewed as the source of a myriad of benefits and harms. However, there are problems with using this notion of "the internet" and other high-level concepts to explain the influence of communicating via everyday networked technologies on people and society. Here, we argue that research on social influence in computer-mediated communication (CMC) requires increased precision around how and why specific features of networked technologies interact with and impact psychological processes and outcomes. Read More

Acta Psychol (Amst) 2022 Jun 27;228:103655. Epub 2022 Jun 27.

School of Psychology, Liaoning Normal University, Liaoning, China. Electronic address:

Although a great deal of research has shown a relationship between numerosity sense and mathematical ability, some studies have failed to do so. The main source of this inconsistency could be the varied ways of measuring mathematical abilities. The current investigation explored several types of mathematical ability, from basic number processing and arithmetic computation to numerical reasoning and arithmetic learning. Read More

Acta Psychol (Amst) 2022 Jun 27;228:103645. Epub 2022 Jun 27.

Paul Baerwald School of Social Work and Social Welfare, Hebrew University of Jerusalem, 91905, Israel.

Background: 'Harmful sexual sibling behavior' is a term used in this study to refer to childhood sexual behaviors, including abuse (SSA), that are inconsistent with the category of age-appropriate curiosity. Although SSA may be the most prevalent and longest-lasting form of intrafamilial sexual abuse, it is the least reported, studied, and treated.

Objective: This study aims to deepen our understanding of the sexual characteristics and dynamics of such behavior, as perceived by those involved. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 25;280:121560. Epub 2022 Jun 25.

School of Information Science and Technology, Fudan University, Shanghai 200438, China. Electronic address:

Raman spectroscopy is a spectroscopic technique typically used to determine vibrational modes of molecules and is commonly used in chemistry to provide a structural fingerprint by which molecules can be identified. With the help of deep learning, Raman spectroscopy can be analyzed more efficiently and thus provide more accurate molecular information. However, no general neural network is designed for one-dimensional Raman spectral data so far. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 24;280:121556. Epub 2022 Jun 24.

Department of Chemistry, University of Nairobi, Kenya.

Although diffuse reflectance spectroscopy (DRS) measurements can be collected rapidly and simultaneously, the resulting datasets are imbalanced and redundant due to the highly correlated spectral features collected on relatively few samples. Consequently, modelling these datasets using machine learning (ML) techniques is challenging and necessitates longer training times and more computational resources. Furthermore, models developed with such data are frequently prone to overfitting, resulting in promising but often non-reproducible results. Read More

Acta Odontol Scand 2022 Jun 30:1-5. Epub 2022 Jun 30.

Folktandvården Stockholm, Public Dental Services, Stockholm County Council, Stockholm, Sweden.

Objective: To investigate whether personnel in a public dental clinic had a higher frequency of ongoing or previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than hospital healthcare workers or the general public in Stockholm during weeks 23-25 in 2020.

Materials And Methods: We carried out an observational cohort study from March to June 2020, including 341 employees randomly selected from Public Dental Service in the County of Stockholm. The primary outcome variable was the prevalence of SARS-CoV-2 RNA and/or antibodies against SARS-CoV-2. Read More

Acta Odontol Scand 2022 Jun 30:1-11. Epub 2022 Jun 30.

Department of stomatology, The First People's Hospital of Lianyungang, Lianyungang, China.

Objective: The aim of this systematic review and meta-analysis is to identify the risk factors of external root resorption (ERR) on second molar (M2) due to presence of impacted third (M3) molar based on cone- beam computerised tomography (CBCT) findings.

Material And Methods: Search of PubMed MEDLINE, SCOPUS, and Experta Medical dataBASE (EMBASE) was performed to identify studies assessing the risk factors of ERR in M2 due to the presence of impacted M3.

Results: M2 in close proximity to mesio-angular impacted M3 had 50% higher risk of root resorption than with vertical impacted M3 (RR 0. Read More

Acta Neuropathol 2022 Jun 30. Epub 2022 Jun 30.

German Cancer Consortium (DKTK), Heidelberg, Germany.

Medulloblastomas (MB) molecularly designated as Group 3 (Grp 3) MB represent a more clinically aggressive tumor variant which, as a group, displays heterogeneous molecular characteristics and disease outcomes. Reliable risk stratification of Grp 3 MB would allow for appropriate assignment of patients to aggressive treatment protocols and, vice versa, for sparing adverse effects of high-dose radio-chemotherapy in patients with standard or low-risk tumors. Here we performed RNA-based analysis on an international cohort of 179 molecularly designated Grp 3 MB treated with HIT protocols. Read More

Acta Paediatr 2022 Jun 30. Epub 2022 Jun 30.

Paediatric Hepatologist, Liver Unit, Children's Hospital, Birmingham, Birmingham, UK.

Acta Psychiatr Scand 2022 Jun 30. Epub 2022 Jun 30.

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Objective: To assess the accuracy of documentation of the symptoms and diagnosis of delirium in medical notes of inpatients with Parkinson's Disease (PD).

Methods: The DETERMINE-PD pilot study assessed PD inpatients over 4-months. Delirium prevalence was classified prospectively using a standardised assessment at a single visit on the basis of Diagnostic and Statistical Manual of Mental Disorders 5 Edition (DSM-5) criteria. Read More

Acta Orthop 2022 Jun 27;93:602-608. Epub 2022 Jun 27.

Division of Orthopaedics and Trauma Surgery, Geneva University Hospitals, University of Geneva, Faculty of Medicine, Geneva, Switzerland; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Background And Purpose:   The influence of postoperative limping on patient satisfaction and amount of limping reduction following THA are not well documented. We (1) assessed if postoperative limping is associated with satisfaction 5 years after THA performed via the lateral or anterior approach; (2) evaluated the influence of surgical approach on amount of limping reduction following THA.

Patients And Methods: We conducted a prospective cohort study of primary elective THAs performed in 2002-2013. Read More

Acta Orthop 2022 Jun 24;93:593-601. Epub 2022 Jun 24.

Division of Orthopaedic Surgery, Oslo University Hospital, Oslo.

Background And Purpose: Dislocation of a hip prosthesis is the 3rd most frequent cause (after loosening and infection) for hip revision in Norway. Recently there has been a shift in surgical practice including preferred head size, surgical approach, articulation, and fixation. We explored factors associated with the risk of revision due to dislocation within 1 year and analyzed the impact of changes in surgical practice. Read More

Acta Biomed 2022 Jun 30;93(S1):e2022106. Epub 2022 Jun 30.

Trauma Unit and Emergency Department, IRCCS Galeazzi Orthopedics Institute, Milano, Italy.

Soft tissue loss around  the elbow, with tendons, nerves and bone exposure,  represents a challenging condition, often requiring a complex and accurate surgical reconstruction. Inadequate repair of soft tissue defects may in fact compromise further reconstructive orthopedic procedures, including  osteosynthesis and joint replacement. A correct reparative sequence of these lesions usually starts with an appropriate debridement and removal of all non-viable and infected tissues, followed by soft tissues management through plastic and reconstructive techniques. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(4):1-2. Epub 2022 Jun 21.

Department of Infectious Diseases and Immunity, Jessa hospital, Hasselt, Belgium.

We hereby describe a case of an acutely ill 41-year-old male without any medical history who presented with an acute abdomen in the emergency department. An abdominal CT showed a dissection of the coeliac trunk and infarction of the spleen. Because of a presumed diagnosis of vasculitis he was started on high dose IV steroids. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(4):1-3. Epub 2022 Jun 21.

Department of Gastroenterology, GZA Sint-Augustinus, Wilrijk, Belgium.

Pancreatic cancer is only rarely associated with myopathy. We present a case of a 69-year-old male with recently diagnosed pancreatic cancer, who presented himself with a paraneoplastic myositis of both legs. MRI and EMG contributed to this diagnosis. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(4):1-3. Epub 2022 Jun 21.

Service de Chirurgie et Transplantation Abdominale, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.

The management of portal hypertension complicated by iterative gastro-intestinal bleeding remains challenging, especially in a low-income environment. Interventional radiology and endoscopic treatments are not always accessible, and a definitive surgical option may prove to be lifesaving. We report a new technique of surgical portosystemic shunt that can be performed in all contexts. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(4):1-3. Epub 2022 Jun 21.

AZ Monica, Department of Gynaecology, Antwerp, Belgium.

A 37-year-old pregnant woman, was diagnosed with acute pancreatitis whilst being infected with COVID-19. Additionally, she had a hyperchylomicronemia and an uncontrolled (most probably, pre-gestational) type 2 diabetes. The coronavirus is able to enter the pancreatic cells through ACE-2 receptors. Read More

Acta Gastroenterol Belg 2022 Jun 27;85(3):1-4. Epub 2022 Jun 27.

Department of Gastroenterology and Hepatology, ZNA Middelheim Hospital, Antwerp, Belgium.

We present a case of marked gastric distension and gastroparesis in a patient with atrial fibrillation who underwent a pulmonary vein isolation, a procedure commonly performed in patients suffering from atrial fibrillation in order to regain sinus rhythm. Two days following the procedure, the patient presented with marked abdominal distension, and computed tomography imaging was consistent with gastroparesis and/or delayed gastric emptying. A tentative diagnosis of pylorospasm was made. Read More

Acta Gastroenterol Belg 2022 Jun 28;85(3):1-6. Epub 2022 Jun 28.

Department of gastroenterology and hepatology, Centres Hospitaliers Jolimont, Haine-Saint-Paul, Belgium.

Background And Study Aim: Patients with alcohol-related cirrhosis have a poor short-term prognosis. We aimed to determine whether the 5-year mortality of alcohol-related cirrhosis has changed over the past two decades in our institution.

Patients And Methods: From January 1995 to December 2014, 932 cirrhotic patients who attended the hepatology outpatient's clinics of our institution were consecutively listed in a registry. Read More

Acta Gastroenterol Belg 2022 Jun 27;85(3):1-7. Epub 2022 Jun 27.

Division of Gastroenterology and Hepatology, University Hospital Saint-Luc, Brussels, Belgium.

Background And Study Aims: Gastrointestinal endoscopic procedures have evolved significantly in the last sixty years revolutionising the approach to the diagnostic and therapeutic spheres of medicine. Despite the advantages of using natural orifices to the bowel, adverse events (AE) may occur following endoscopy. Systematic AE registration is an objective in every realm of quality medicine. Read More

Acta Gastroenterol Belg 2022 Jun 27;85(3):1-7. Epub 2022 Jun 27.

Gastroenterology Department. Hospital Universitario de Navarra. Pamplona, Spain.

Background: Small bowel capsule endoscopy (SBCE) is a noninvasive method to detect endoscopic postoperative recurrence (POR) after an ileocolonic resection in Crohn's Disease (CD). Few studies have evaluated the role of SBCE in the early POR (= 12 months). Data for detection of late POR (>12 months) and evaluation of treatment response in previous POR is scarce. Read More

Acta Gastroenterol Belg 2022 Jun 27;85(3):1-7. Epub 2022 Jun 27.

Department of Hepatobiliary surgery, Organ Transplantation center, Tianjin First Central Hospital, Tianjin Clinical Research Center for Organ Transplantation, Tianjin, 300192, China.

Objective: To establish a new psoas muscle depletion index (PDI) from healthy young donors and to explore the correlation between the PDI and the severity of cirrhosis in patients with endstage liver disease (ESLD).

Methods: Clinical data of 461 healthy donors were collected during the period 2014-2019, and clinical data of 331 patients with ESLD were collected during the period 2014-2018. The patients were divided into four groups by PDI severity: PDI ≥ 0. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(3):1-5. Epub 2022 Jun 21.

Department of Gastroenterology and Hepatology, AZ St. Maarten, Mechelen, Belgium.

Background: Relieving dysphagia is the main goal of palliative care in advanced esophageal cancer. We aimed to evaluate the safety and clinical performance of the Niti-S esophageal double covered, anti-reflux stent (Taewoong Medical, Seoul, Korea) in inoperable carcinoma of the esophagus or gastric cardia.

Methods: This was a retrospective patient registry/post-market clinical follow-up study of all patients with esophageal malignant strictures undergoing self-expandable metal stent (SEMS) placement with the Niti-S Esophageal covered stent, double antireflux in a community hospital (AZ St Maarten Mechelen, Belgium) between March 2013 and July 2021. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(3):1-7. Epub 2022 Jun 21.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Background And Study Aims: The gastrointestinal (GI) tract is the most common site of extra-nodal involvement for non-Hodgkin's lymphoma (NHL). The features of GI NHLs remain unclear. The aim of this study was to clarify endoscopic characteristics of GI NHLs. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(3):1-7. Epub 2022 Jun 21.

Department of Radiation Oncology, University of Health Sciences Turkey, Gulhane Faculty of Medicine, Ankara, Turkey.

Background: Liver metastases may occur during the course of several cancer types and may be associated with significant morbidity and mortality. There is paucity of data regarding the utility of Active Breathing Control (ABC) guided Stereotactic Ablative Body Radiotherapy (SABR) for management of Liver Metastases from Colorectal Cancer (LMCC). Our aim is to investigate the role of ABC guided SABR for management of liver metastases. Read More

Acta Gastroenterol Belg 2022 Jun 21;85(3):1-5. Epub 2022 Jun 21.

Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Aim: To systematically investigate the timing of encapsulation of necrotic collections in acute necrotizing pancreatitis (ANP) using contrast-enhanced computed tomography (CECT).

Methods: This retrospective study comprised consecutive patients of ANP who underwent CECT of the abdomen between the second and fourth weeks of illness. Number and site of collections and presence and completeness of the wall (defined as a thin smooth enhancing rim more than 1 mm in thickness) were documented. Read More