4,675 results match your criteria Acta Poloniae Pharmaceutica[Journal]


DEVELOPMENT OF AROMA IN SPROUTING SATUREJA HORTENSIS.

Acta Pol Pharm 2017 Mar;74(2):706-709

View Article

Download full-text PDF

Source

ANTIOXIDANT AND CANCER CHEMOPREVENTIVE ACTIVITIES OF CISTUS AND POMEGRANATE POLYPHENOLS.

Acta Pol Pharm 2017 Mar;74(2):688-698

Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peel (Punica granatum L.) exhibited significant antioxidant activity in V79 cell culture (Chinese hamster lung fibroblasts) -cistus extract reduced intracellular content of reactive oxygen species (ROS) by 30-40% and pomegranate extract by 29-36%. Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

ACTIVITY OF BLACKCURRANT AND CHOKEBERRY EXTRACTS AND TWO MAJOR CYANIDIN GLYCOSIDES AGAINST LIPID MEMBRANE OXIDATION AND THEIR BINDING PROPERTIES TO ALBUMIN.

Acta Pol Pharm 2017 Mar;74(2):679-687

The purpose of this study was to explain how extracts from chokeberry and blackcurrant interact with the lipid phase of biological membrane and with human albumin - the main protein of blood. Aiming at better understanding of the observed biological activity of the extracts, we also conducted experiments with their main components: cyanidin-3-0-galactoside and cyanidin-3-0-ruthinoside. Antioxidant activities of extracts and cyanidin derivatives were investigated with phosphatidy1choline liposomes and AAPH as oxidation inducing factor. Read More

View Article

Download full-text PDF

Source
March 2017
4 Reads

CONDITIONS OF PROOXIDANT ACTIVITY OF CISTUS AND POMEGRANATE POLYPHENOLS IN V79 CELL CULTURES.

Acta Pol Pharm 2017 Mar;74(2):670-678

Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peels (Punica granatunm L.) added at high concentrations (25-100 pg/mL) to V79 (Chinese hamster lung fibroblast) cell cultures, markedly increased intracellular level of ROS (reactive oxygen species). Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

POLYPHENOL CONTENT AND BIOACTIVITY OF SASKATOON (AMELANCHIER ALNIFOLIA NUTT.) LEAVES AND BERRIES.

Acta Pol Pharm 2017 Mar;74(2):660-669

The studies were designed to determine the polyphenolic composition and biological activity of extracts from fruits (SFE) and leaves (SLE) of Saskatoon (Amelanchier alnifolia Nutt.) in relation to erythrocyte membranes. A detailed quantitative and qualitative analysis of extracts was conducted, using the chro- matographic (UPLC-DAD, UPLC-ESI-MS) and spectrophotometric (Folin-Ciocalteu) methods. Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

FLAX OIL FROM TRANSGENIC LINUM USITATISSIMUM SELECTIVELY INHIBITS IN VITRO PROLIFERATION OF HUMAN CANCER CELL LINES.

Acta Pol Pharm 2017 Mar;74(2):653-659

Emulsions made of oils from transgenic flaxseeds significantly decreased in vitro proliferation of six tested human cancer cell lines in 48-h cultures, as assessed with the standard sulforhodamine assay. However, the emulsions also increased proliferation rate of normal human dermal fibroblasts and, to a lower extend, of keratinocytes. Both inhibition of in vitro proliferation of human cancer cell lines and stimulation of proliferation of normal dermal fibroblasts and keratinocytes were especially strong with the emulsion type B and with emulsion type M. Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

IMPACT OF FABRICS FROM TRANSGENIC FLAX PLANT ON HUMAN DERMAL FIBROBLASTS IN VITRO PROLIFERATION.

Acta Pol Pharm 2017 Mar;74(2):642-652

Previously it was documented that transgenic flax plants, which contained an increased level of polyphenolic compounds, significantly improved healing of skin wounds lesions. In order to recognize mechanisms of beneficial action of transgenic flax fabrics on wound healing, in the present study the impact of flax fabric pieces/cuts from three types of transgenic flax on normal human dermal fibroblasts primary culture (NHDF) was investigated. NHDF cell cultures were exposed for 48 h to specific area of flax fabric cuts, made from M50, B 14 and M50+B14 (intertwined fibers of M and B), or parallely, extracts from fibers of the tested flax materials to cell culture medium. Read More

View Article

Download full-text PDF

Source
March 2017
8 Reads

IN VIVO STUDIES AND STABILITY STUDY OF CLADOPHORA GLOMERATA EXTRACT AS A COSMETIC ACTIVE INGREDIENT.

Acta Pol Pharm 2017 Mar;74(2):633-641

Marine algae are widely used as cosmetics raw materials. Likewise, freshwater alga Cladophora glomerata may be a good source of fatty acids and others bioactive agents. The aims of this study was to find out if the addition of the extract from the freshwater C. Read More

View Article

Download full-text PDF

Source
March 2017
14 Reads

INFLUENCE OF POMEGRANATE SEED OIL AND GRAPE SEED OIL ON CHOLESTEROL CONTENT AND FATTY ACIDS PROFILE IN LIVERS OF CHICKENS.

Acta Pol Pharm 2017 Mar;74(2):624-632

Oils are important food ingredients, mainly as a source of unsaturated fatty acids. The offer of novel edible oils from herbs, spices and fruit seeds has grown and many of them are used as functional food and dietary supplements but also as feed additives in animal feeding. Poultry meat is recommended. Read More

View Article

Download full-text PDF

Source
March 2017
1 Read

ANTICANCER ACTIVITY OF OAT β-GLUCAN IN COMBINATION WITH ELECTROPORATION ON HUMAN CANCER CELLS.

Acta Pol Pharm 2017 Mar;74(2):616-623

The currently available data suggest that natural products may exert significant cytotoxic and immunomodulatory effects. Plant-derived chemotherapeutic agents such as taxol, etoposide or vincristine, currently used in cancer therapy, are prominent examples in this regard. However, there is a need for new and nat- ural anticancer compounds with low or without toxicity to normal cells. Read More

View Article

Download full-text PDF

Source
March 2017
13 Reads

INFLUENCE OF ORGANIC FOLIAR FERTILIZATION ON ANTIOXIDANT ACTIVITY AND CONTENT OF POLYPHENOLS IN OCIMUM BASILICUM L.

Acta Pol Pharm 2017 Mar;74(2):611-615

Basil is an important medicinal and culinary herb, cultivated on large areas in many countries. With the growing necessity of ecological products, organic crops need to be expanded, but a more complete characterization of such agriculture systems is required. The present paper aims to evaluate total phenolics and flavonoid contents, antioxidant activity of Ocimum basilicum L. Read More

View Article

Download full-text PDF

Source
March 2017
5 Reads

CURCUMA LONGA AS MEDICINAL HERB IN THE TREATMENT OF DIABET- IC COMPLICATIONS.

Acta Pol Pharm 2017 Mar;74(2):605-610

Curcuma longa L. (turmeric) of ginger family (Zingiberaceae) belongs to the group of oldest cultivated spice plants in the south-east Asian countries. For many years rhizome of this plant has been used also as a safe and active drug for the treatment of various. Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

WHAT MOTIVATES POLISH COMMUNITY PHARMACISTS TO PURSUIT OF POSTGRADUATE EDUCATION?.

Acta Pol Pharm 2017 Mar;74(2):587-596

Due to increasing importance of the advisory role for physicians and patients played by the pharmacist over the last decade, it seems appropriate to evaluate if and why pharmacists are interested in postgraduate medical education. The purpose of the study was to develop and validate an instrument to assess such motives, with special interest to Polish community pharmacists. A self-administered questionnaire was completed by a sample of participants of community pharmacist specialization programs and it was analyzed in relation to participants of other postgraduate courses. Read More

View Article

Download full-text PDF

Source
March 2017
1 Read

COMPARISON OF THE EFFECTS OF MARSANIDINE DERIVATIVES ON RAT CARDIOVASCULAR SYSTEM.

Acta Pol Pharm 2017 Mar;74(2):579-586

Since clonidine was introduced in clinical practice, attempts are still made to obtain substances capable of centrally controlling blood pressure, however with pharmacological profile better than currently avail- able, such as moxonidine and rilmenidine. Recently synthesized indazole derivatives exert promising action on blood pressure and heart rate in Wistar rats. In the present study, our aim was to check which of tested substituted compound exerts the best effect on basic circulatory parameters. Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

DEVELOPMENT AND EVALUATION OF IVABRADINE HCI-LOADED POLYMERIC MICROSPHERES PREPARED WITH EUDRAGIT L100-55 (METHACRYLIC ACID-ETHYL ACRYLATE COPOLYMER) AND ETHYL CELLULOSE FOR CONTROLLED DRUG RELEASE.

Acta Pol Pharm 2017 Mar;74(2):565-578

The objective of this study was to prepare and evaluate ivabradine HCl-loaded microspheres consisting of Eudragit LIOO-55 and ethyl cellulose prepared by oil-in-oil solvent evaporation method. Ivabradine HCl was encapsulated into microspheres by in situ method. The resultant microspheres were characterized with respect to drug loading, flow properties, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermal analysis and release behavior. Read More

View Article

Download full-text PDF

Source
March 2017
18 Reads

HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT OF FORMULATION VARIABLES ON GRANULES AND TABLETS CHARACTERISTICS OF HIGH DRUG LOADING FORMULATION USING DESIGN OF EXPERIMENT METHODOLOGY.

Acta Pol Pharm 2017 Mar;74(2):551-564

High shear wet granulation is a significant component procedure in the pharmaceutical industry. The objective of the study was to investigate the influence of two independent formulation variables; polyvinypyrrolidone (PVP) as a binder (X,) and croscarmellose sodium (CCS) as a disintegrant (X2) on the crit- ical quality attributes of acetaminophen granules and their corresponding tablets using design of experiment (DoE) approach. A two factor, three level (32) full factorial design has been applied; each variable was investi- gated at three levels to characterize their strength and interaction. Read More

View Article

Download full-text PDF

Source
March 2017
6 Reads

MODELLING AND BIOPHARMACEUTICAL EVALUATION OF CICLOPIROX OLAMINE GELS.

Acta Pol Pharm 2017 Mar;74(2):543-549

The ciclopirox olamine (CPO) has a broad antimicrobial profile including dermatophytes, yeasts and is used in various pharmaceutical forms. The aim of this study is to evaluate the quality of the CPO gels according to biopharmaceutial tests in vitro and antifungal activity assay. Hydroxypropyl cellulose, chitosan and poloxamer 407 were selected as agents gelificants. Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

MICROWAVE RADIATION INDUCED SYNTHESIS OF HYDROXYPROPYL METHYLCELLULOSE-GRAFT- (POLYVINYLALCOHAL-CO-ACRYLIC ACID) POLYMERIC NETWORK AND ITS IN VITRO EVALUATION.

Acta Pol Pharm 2017 Mar;74(2):527-541

A microwave induced irradiation synthesis, was proposed for the preparation of hydroxypropyl methylcellulose-graft-(polyvinylalcohal-co-acrylic acid) hydrogels. The hydrogels were separately synthesized by using microwave irradiation method and conventional water bath heating method. Moreover, the prepared hydrogels were loaded with an antihypertensive drug, captopril. Read More

View Article

Download full-text PDF

Source
March 2017
18 Reads

NANOEMULSION WITH CLOTRIMAZOLE - DESIGN AND OPTIMALIZATION OF MEAN DROPLET SIZE USING MICROFLUIDIZATION TECHNIQUE.

Acta Pol Pharm 2017 Mar;74(2):519-526

Poor water solubility of clotrimazole (CLO) hinders development of the effective pharmaceutical dosage forms. Many different concepts and approaches, including lipid based formulations, have been undertaken to improve delivery of CLO. The purpose of this study was to design the composition of nanoemulsion with CLO for topical use, which could be processed by microfluidization method. Read More

View Article

Download full-text PDF

Source
March 2017
7 Reads

COLOCASIA ESCULENTA CORMS MUCILAGE-ALGINATE MICROSPHERES OF OXCARBAZEPINE: DESIGN, OPTIMIZATION AND EVALUATION.

Acta Pol Pharm 2017 Mar;74(2):505-517

The present investigation was undertaken with an objective of formulating sustained release microspheres of oxcarbazepine (OXC), an anti-epileptic drug, to overcome poor patient compliance and exposure to high doses associated with currently marketed OXC dosage forms. Ionic gelation technique was used to prepare OXC microspheres by using sodium alginate along with rate controlling polymer Colocasia esculenta mucilage (CEM) matrix as well coated form. The microspheres have been characterized by differential scanning calorimetry (DSC) for understanding thermal stability and Fourier transform infrared (FT-IR) spectroscopy to investigate the chemical interaction as well as to assess the structure of drug-loaded formulation. Read More

View Article

Download full-text PDF

Source
March 2017
5 Reads

FORMULATION AND ASSESSMENT OF SEMI-SOLID CARRIER INCORPORATED WITH HERBAL EXTRACT OF LAWSONIA INERMIS.

Acta Pol Pharm 2017 Mar;74(2):497-504

The development of an optimal microemulsion of lawsone for transdermal delivery was the core objective of the study. Effects of formulation variable including oils, surfactants and co-surfactants on the per- cutaneous delivery of lawsone microemulsion have also been inspected. Pseudotemary phase diagrams with oil, cosurfactant-surfactant mixtures (Smix) were constructed to recognize the microemulsion areas. Read More

View Article

Download full-text PDF

Source
March 2017
25 Reads

PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta Pol Pharm 2017 Mar;74(2):489-495

Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood samples were drawn at 0.5, 1, 1. Read More

View Article

Download full-text PDF

Source
March 2017
5 Reads
0.693 Impact Factor

ASSESSMENT OF A STABLE COSMETIC PREPARATION BASED ON ENZYMATIC INTERESTERIFIED FAT, PROPOSED IN THE PREVENTION OF ATOPIC DERMATITIS.

Acta Pol Pharm 2017 Mar;74(2):465-476

Atopic dermatitis is one of the most common skin disorders seen in infants, children and adults. Proper prevention might slow the atopic symptoms. The purpose of the work was a sensory analysis, an evaluation of moistening properties and stability of emulsions based on an enzymatic interesterified fat blend (mutton tallow and walnut oil) and homogenized at different revolutions and different contents of thickener. Read More

View Article

Download full-text PDF

Source
March 2017
4 Reads

DEVELOPMENT OF COMPRESSED COATED POLYPILL WITH MUCOADHESIVE CORE COMPRISING OF ATORVASTATIN/CLOPIDOGREL/ASPIRIN USING COMPRESSION COATING TECHNIQUE.

Acta Pol Pharm 2017 Mar;74(2):477-487

The study was conducted to formulate and assess a novel polypill comprising of atorvastatin calci- um (ATVC), clopidogrel bisulfate (CLB) and aspirin (ASP) which, after in vivo correlation, can be intended for use in hyperlipidemic chronic heart disease patients. Polypill was made by the compression coating technique (CCT) with multiple active ingredients along with different concentrations of mucoadhesive and sustained release polymers, i.e. Read More

View Article

Download full-text PDF

Source
March 2017
4 Reads

STABILITY OF SOLUTIONS OF 2,3-DIPHENYLCYCLOPROPENONE IN VARIOUS SOLVENTS. A NOVEL FORMULA - DIPHENYLCYCLOPROPENONE IN ISOPROPANOL MAY BE USEFUL IN TOPICAL THERAPY OF PATIENTS WITH ALOPECIA AREATA.

Acta Pol Pharm 2017 Mar;74(2):459-464

The aim of this study was to evaluate the chemical stability of diphenylcyclopropenone (DCP) in var- ious solvents. DCP is being used in topical therapy in patients with alopecia areata (AA). The solvents for DCP used so far were acetone, ethanol and propylene glycol. Read More

View Article

Download full-text PDF

Source
March 2017
30 Reads

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 2,3-DISUBSTITUTED AND FUSED QUINOXALINES AS POTENTIAL ANTICANCER AND ANTIMICROBIAL AGENTS.

Acta Pol Pharm 2017 Mar;74(2):445-458

This article describes the synthesis of new bioactive quinoxalines as potential anticancer and antimicrobial agents; 2,3-dichloroquinoxaline was used as the key molecule for the preparation of various mono or disubstituted quinoxalines 2-7, pyridoimidazoquinoxaline derivative 8, thiazolo[4,5-b]quinoxaline derivatives 9-11, piperazinoquinoxaline derivatives 12, 13 and 1,4-benzoxazino[2,3-b]quinoxaline 15. The newly synthesized compounds were evaluated for their anticancer and antimicrobial activity. Assay results showed the compounds 6-bromo-2-chloro-N-[4-(trifluoromethyl)phenyl]-3-aminoquinoxaline (4), 7-bromo-2-[2-(4-methoxy-benzylidene) hydrazinyl]thiazolo[5,4-b]quinoxaline (9d) and 7-bromo-1,2,3,4-tetrahydropyrazino[2,3- blquinoxaline (12) proved to possess dual effects as potential anti-cancer and antimicrobial agents. Read More

View Article

Download full-text PDF

Source
March 2017
1 Read

SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 6-PHENYL-1H-PYRROLO[3,4-c]PYRIDINE-1,3-DIONE DERIVATIVES.

Acta Pol Pharm 2017 Mar;74(2):435-443

The new pyrrolo[3,4-c]pyridines have been synthesized. 4-Methyl-6-phenyl-1H-pyrrolo[3,4-cpyridine-1,3-dione (1) was the key intermediate for the synthesis of the novel derivatives of various chemical structures. In the first step, the pyrrolo[3,4-c]pyridine-1,3-dione 1 was alkylated to the corresponding N-alkyl-4- methyl-6-phenyl-IH-pyrrolo[3,4-c]pyridine-1,3-dione derivatives 2a-f. Read More

View Article

Download full-text PDF

Source
March 2017
44 Reads

ANTIOXIDANTS AND ANTIFUNGAL ACTIVITIES OF SUBSTITUTED GUANIDINES AND THEIR COPPER COMPLEXES.

Acta Pol Pharm 2017 Mar;74(2):425-434

A series of guanidines and their copper (II) complexes were investigated for their radical scavenging activity including peroxyl radicals (ROO), superoxide anion (O₂), hydroxyl ('OH), and reactive hydrogen per- oxide (H₂0₂) species. Among the Cu(II) complexes, Cu-MR-9-2 shows the highest, Cu-MR-9-3, Cu-MR-9-6 less and Cu-MR-9-1 least antioxidant potential. The Cu(II) complexes show better Fea'-chelating activity than that of ligands. Read More

View Article

Download full-text PDF

Source
March 2017
8 Reads

INCREASED OXIDATIVE STRESS AND DOWN REGULATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) IN THE KIDNEY ATTEN- UATE THE RESPONSIVENESS OF (XlB ADRENERGIC RECEPTORS IN THE KIDNEY OF RATS WITH LEFT VENTRICULAR HYPERTROPHY.

Acta Pol Pharm 2017 Mar;74(2):413-423

Present study explored endothelial nitric oxide synthase/nitric oxide (eNOS/NO) pathway in the kidney and role of αIB adrenergic receptor in the regulation of renal vasculature in the rats with left ventricular hypertrophy (LVH). LVH was induced by administering isoprenaline 5 mg/kg (s.c. Read More

View Article

Download full-text PDF

Source
March 2017
7 Reads

SIMULTANEOUS ASSAY OF ARIPIPRAZOLE AND ITS ACTIVE METABOLITE IN SERUM BY HPLC.

Acta Pol Pharm 2017 Mar;74(2):405-411

A rapid, convenient, precise HPLC method was developed for the simultaneous determination of aripiprazole and its active metabolite dehydroaripiprazole in blood serum. The separation was carried out by RP HPLC on Symmetry C₁₈ column (150 x 4.6 mm; 5 μm). Read More

View Article

Download full-text PDF

Source
March 2017
1 Read

DEVELOPMENT AND VALIDATION OF BROMATOMETRIC, DIAZOTIZATION AND VIS-SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF MESALAZINE IN PHARMACEUTICAL FORMULATION.

Acta Pol Pharm 2017 Mar;74(2):401-404

Three new methods were developed for the quantitative determination of mesalazine in the form of the pure substance or in the form of suppositories and tablets - accordingly: bromatometric, diazotization and visible light spectrophotometry method. Optimizing the time and the temperature of the bromination reaction (50⁰C, 50 min) 4-amino-2,3,5,6-tetrabromophenol was obtained. The results obtained were reproducible, accurate and precise. Read More

View Article

Download full-text PDF

Source
March 2017
4 Reads

NEW RENIN INHIBITORS - STABILITY AND ACTIVITY DETERMINATION. PART IV.

Acta Pol Pharm 2017 Mar;74(2):393-399

A series of new seven potential renin inhibitors containing pseudodipeptides were synthesized. Stability for all compounds (1-7) in homogenates of liver, kidney, lung and in serum, gastric, intestinal juice and in the presence of α-chymotrypsin was determined. Compound 1 was unstable in all determined mediums. Read More

View Article

Download full-text PDF

Source

DEVELOPMENT AND VALIDATION OF FAST REVERSED-PHASE HPLC METHOD FOR ANALYSIS OF ESOMEPRAZOLE IN RABBIT PLASMA.

Acta Pol Pharm 2017 Mar;74(2):385-391

The present study focused to develop rapid, accurate and sensitive reversed-phase high pressure liquid chromatography method for the quantification of esomeprazole (ESO) magnesium in rabbit plasma. Chromatographic separation was achieved isocratically on a reversed-phase C,, column using simple mobile phase consisting of of methanol : acetonitrile: 0.05 M phosphate buffer, pH 7 adjusted with potassium hydroxide (45 : 10 : 45, v/v/v) at a flow rate of 1. Read More

View Article

Download full-text PDF

Source
March 2017
6 Reads

REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DETERMINATION OF 5-FLUOROURACIL IN RABBIT PLASMA.

Acta Pol Pharm 2017 Mar;74(2):379-383

A simple, efficient, accurate and selective HPLC method has been developed and validated successfully for the estimation of 5-fluorouracil in rabbit plasma. The drug was eluted by using Supelco C18 column (1.5 cm x 4. Read More

View Article

Download full-text PDF

Source
March 2017
4 Reads

POTENTIOMETRIC STUDY OF Pd(II) COMPLEXES OF SOME FLAVONOIDS IN WATER-METHANOL-1,4-DIOXANE-ACETONITRILE (MDM) MIXTURE.

Acta Pol Pharm 2017 Mar;74(2):369-377

The potentiometric method was used to determine the protonation (dissociation) constants for morin, rutin and chrysin and the composition and formation constants of the Pd(II)-flavonoid complexes in the water/methanol/acetonitrile/1,4-dioxane mixture (water/MDM). All investigations were carried out at a constant ionic strength of I = 0.2 (KCI) at 298 K. Read More

View Article

Download full-text PDF

Source

DEVELOPMENT AND VALIDATION OF HPLC ANALYTICAL METHODS USED-FOR DETERMINATION OF ASSAY, CONTENT UNIFORMITY AND DISSOLUTION OF IMMEDIATE RELEASE CANDESARTAN CILEXETIL 32 MG TABLETS.

Acta Pol Pharm 2017 Mar;74(2):357-367

New analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies were performed on cyano column. Mobile phase of assay and content uniformity test consisted of mixture of 0. Read More

View Article

Download full-text PDF

Source
March 2017
13 Reads

APPLICATION OF VARIOUS POLYMERS AND POLYMERS BASED TECHNIQUES USED TO IMPROVE SOLUBILITY OF POORLY WATER SOLUBLE DRUGS: A REVIEW.

Acta Pol Pharm 2017 Mar;74(2):347-356

Solubility is concerned with solute and solvent to form a homogenous mixture. If solubility of a drug is low, then usually it is difficult to achieve desired therapeutic level of drug. Most of the newly developed entities have solubility problems and encounter difficulty in dissolution. Read More

View Article

Download full-text PDF

Source
March 2017
6 Reads

ANALYSIS OF BASIC PSYCHOTROPIC DRUGS IN BIOLOGICAL FLUIDS AND TISSUES BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY.

Acta Pol Pharm 2017 Mar;74(2):331-346

The review of the RP HPLC analysis of basic psychotropic drugs is presented. It contains sample preparation methods with centrifugation, protein precipitation, liquid-liquid extraction (LLE), dispersive liquid-liquid microextraction (DLLME), solid-phase extraction (SPE), solid-phase microextraction (SPME), microwave-assisted extraction (MAE) and RP-HPLC analysis. Chromatographic behavior of basic drugs in aqueous media - eluents used in reversed phase systems is discussed. Read More

View Article

Download full-text PDF

Source
March 2017
3 Reads

CAPSAICIN: ITS BIOLOGICAL ACTIVITIES AND IN SILICO TARGET FISHING.

Acta Pol Pharm 2017 Mar;74(2):321-329

Capsicum annuum L. is a rich source of capsaicin, an alkaloid, which is a very pungent compound. Due to ever growing need of capsaicin, an extensive research on its efficient cultivation as well as chemical synthesis is underway. Read More

View Article

Download full-text PDF

Source
March 2017
1 Read

REMEDIAL APPLICATIONS OF EXOSOMES IN CANCER, INFECTIONS AND DIABETES.

Acta Pol Pharm 2017 Mar;74(2):313-320

Different cell types under normal and diseased states constantly secrete numerous membrane vesicles including exosomes into extracellular space wkich can be isolated from various biological fluids and cell culture supernatants. Exosomal diameter ranges between 40-100 nm. In current research, exosomes are being exploited as biomarkers for pathological diagnosis and potential remedy against various disease conditions such as infections and autoimmune disorders. Read More

View Article

Download full-text PDF

Source
March 2017
2 Reads

NURSE PRESCRIBING. KNOWLEDGE AND ATTITUDES OF POLISH NURSES IN THE EVE OF EXTENDING THEIR PROFESSIONAL COMPETENCES: CROSS-SECTIONAL STUDY.

Acta Pol Pharm 2017 May;74(3):1031-1038

In Poland, since 1 January 2016 nurses who graduated from the master studies or hold a title of a specialist may ordain and prescribe specific medicines ("independent nurse prescribing" - INP). Nurses, who completed bachelor studies or hold a title of a specialist are allowed to prescribe drugs to continue the patient's treatment as ordered by a physician ("supplementary nurse prescribing" - SNP). The aim of this paper was to analyze the knowledge and attitudes of the Polish nurse specialists to their new professional rights in the independent ordaining of some drugs and drug prescribing. Read More

View Article

Download full-text PDF

Source
May 2017
1 Read

PHARMACEUTICAL CARE IN OPINION OF POLISH MEDICAL AND PHARMACEUTICAL STUDENTS: AN EXPLORATORY STUDY.

Acta Pol Pharm 2017 May;74(3):1021-1030

Pharmacy students should have a sufficient level of knowledge, skills, and attitude to practice pharmaceutical care effectively in the routine practice in the community pharmacy. Moreover, the strong cooperation between pharmacists and physicians is strongly needed in the process of providing pharmaceutical care. The aim of the study was to investigate the opinions of students of the Faculty of Medicine and Pharmacy from Medical University of Gdansk on pharmaceutical care and cognitive services and aspects of interprofessional collaboration between physicians and pharmacists under the conditions of Polish healthcare system. Read More

View Article

Download full-text PDF

Source
May 2017
1 Read

QUALITY OF PHARMACEUTICAL CARE AT THE STAGE OF PATIENTS' NEEDS IDENTIFICATION UNDER CONDITIONS OF COMMUNITY PHARMACIES AS A TRANSBORDER PROBLEM.

Acta Pol Pharm 2017 May;74(3):1011-1019

The results of the study of the real pharmaceutical practice in relation to the patient's needs identification defined that the problem of not always high pharmaceutical care quality at this stage is equally up-to-date for the community pharmacies of Lviv (Ukraine) and Lublin (Poland). It was found that the quantity and amount of questions set by a pharmacist are not related to the conversation duration with a pharmacy visitor, and the communication duration does not have the statistically confirmed dependence on the queue availability, therefore in the context of pharmaceutical care quality, these criteria are of no high importance. Instead, drug-related problems (n = 209) verified by the authors of this article,tthat have been distributed into the groups according to the criterion of the information amount received by a pharmacist studying the needs of the patient (visitor of a pharmacy), were determined as a quantitative indicator of potential pharmaceutical care quality increase. Read More

View Article

Download full-text PDF

Source
May 2017
2 Reads

MOTIVATIONS SURROUNDING THE PURSUIT OF A PHARMACY CAREER - THE CASE OF POLISH STUDENTS.

Acta Pol Pharm 2017 May;74(3):1001-1010

The objective was to examine the motivation for studying pharmacy. A self-administered questionnaire, developed and validated by the authors, was completed by a sample of 414 Polish pharmaceutical students (Year I - Year 5). The students ranked their motives on a Likert-like scale and their underlying dimensions were identified using exploratory and confirmatory techniques. Read More

View Article

Download full-text PDF

Source
May 2017
1 Read