675,092 results match your criteria Acta Phytotaxonomica Et Geobotanica[Journal]


A case report and literature review of vaginal bleeding in prepubertal girl.

Acta Paediatr 2020 Jul 11. Epub 2020 Jul 11.

Department of Gynecology, Zhejiang Provincial People's Hospital, People's Hospital Of Hangzhou Medical College, Hangzhou, P.R. China.

Vaginal bleeding in the prepubertal girl is an uncommon condition with complex etiological factors. We report a case of a 6-year-old girl brought to hospital when vaginal bleeding was noticed after defecation. Various common causes were excluded by genital and auxiliary examinations. Read More

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http://dx.doi.org/10.1111/apa.15479DOI Listing

Role of prenatal magnetic resonance imaging in fetuses with isolated agenesis of corpus callosum in the era of fetal neurosonography: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2020 Jul 11. Epub 2020 Jul 11.

Center for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University Hospital of Chieti, Chieti, Italy.

Introduction: Corpus callosum agenesis (ACC) is frequently diagnosed during fetal life; its prognosis depends also on additional anomalies. The additional value of fetal magnetic resonance imaging (MRI) in fetuses with 'isolated' complete (cACC) and partial (pACC) agenesis of the corpus callosum on ultrasound is still debated.

Material And Methods: We performed a systematic literature review and meta-analysis including fetuses with a prenatal diagnosis of cACC and pACC without associated structural anomalies on ultrasound, undergoing fetal MRI. Read More

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http://dx.doi.org/10.1111/aogs.13958DOI Listing

Postpartum urinary retention in women undergoing instrumental delivery: a cross sectional analytic study.

Acta Obstet Gynecol Scand 2020 Jul 11. Epub 2020 Jul 11.

Department of Obstetrics & Gynecology, Jawaharlal Institute of Medical Education & Research, Puducherry, India.

Introduction: Women undergoing instrumental delivery are known to be at higher risk of urinary retention, which can lead to long term complications such as voiding dysfunction Nulliparous women undergo a pronounced and sudden change in perineum due to stretching during delivery which may add to the perineal trauma from an episiotomy, increasing the risk of urinary retention. We aim to study the incidence and risk factors associated with postpartum urinary retention in women undergoing instrumental delivery.

Material And Methods: Pregnant women who had instrumental delivery after 37 weeks of gestation, at JIPMER, Puducherry, India between January - June 2017 were included in the study. Read More

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http://dx.doi.org/10.1111/aogs.13954DOI Listing

Theoretical study on predissociation of BΣ of sulfur dimer.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118679. Epub 2020 Jul 2.

Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China. Electronic address:

A high level ab initio study on electronic states of sulfur dimer S is carried out by utilizing multi-reference configuration interaction plus Davidson correction (MRCI+Q) method. The modification to the electronic structures caused by spin-orbit coupling (SOC) effect is taken into consideration by the state-interacting method with the full Breit-Pauli Hamiltonian. The potential energy curves (PECs) of 19 Λ-S states and 52 Ω states generated from the Λ-S states are calculated. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118679DOI Listing

Ammonia borane structural study by temperature through high-resolution Raman spectroscopy and principal component analysis.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118661. Epub 2020 Jul 2.

Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, 04510 Mexico City, Mexico.

The structural change by temperature of the ammonia borane has been studied through Raman spectroscopy and principal components analysis (PCA). Its phase transition, from tetragonal to orthorhombic, was observed at 212 K. In addition, between 99 and 83 K, a zone of structural stability was observed. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118661DOI Listing

Theoretical study on resonance Raman spectra of meso-tetrakis(3,5-di-tertiarybutylphenyl)-porphyrin due to the second-order Herzberg-Teller mechanism.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118659. Epub 2020 Jul 2.

Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun, Beijing 100190, People's Republic of China.

Using quantum chemistry computations TDDFT//B3LYP/6-31G(d), we study resonance Raman spectra of the Q band for meso-tetrakis(3,5-di-tertiarybutylphenyl)-porphyrin (HTBPP) molecule due to the Franck-Condon and non-Condon mechanisms including the Herzberg-Teller and second-order Herzberg-Teller terms. Generally, the Herzberg-Teller terms are large. However, for some vibrational modes, the second-order Herzberg-Teller terms are the strongest and dominate resonance Raman spectra, which may also impact on fluorescence and absorption spectra. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118659DOI Listing

Simultaneous absorption of UV-vis and circular dichroism to measure enantiomeric concentrations of praziquantel under nonlinear conditions.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 3;241:118645. Epub 2020 Jul 3.

DEQ/EQ, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, bloco E, sala 209, Cidade Universitária, Rio de Janeiro CEP 21.941-972, Brazil.

Beer-Lambert-Bouguer law is for a limiting case and, therefore, it is not useful to describe the relationship between absorption signal and enantiomer concentration in a stream when there are nonlinear phenomena present. In this work, the Chiral Detector (CD-2095 JASCO) equipment was used to measure simultaneously the UV-Vis and circular dichroism (CD) signals of a stream with different compositions of praziquantel enantiomers. The tested models were calibrated (parameter estimation) and validated using the Leave-One-Out Cross Validation (LOOCV) method. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118645DOI Listing

Spectroscopic studies for the inclusion complexation of ketoprofen enantiomers with β-cyclodextrin.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118674. Epub 2020 Jul 2.

Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia; Centre for Ionic Liquids, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. Electronic address:

Inclusion complexes of R-ketoprofen and S-ketoprofen enantiomers with β-cyclodextrin (β-CD) in aqueous solution were studied using various spectroscopic techniques such as Raman, FTIR, UV and fluorescence. The different relative intensities and characteristic band shifts of the two enantiomers from Raman spectra suggests different interaction when complexed with β-CD. Raman experiments revealed a noticeable diminishing of the CC vibration and ring deformation, which indicate the embedding of ketoprofen inside the β-CD cavity. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118674DOI Listing

Stretching force constants as descriptors of energy and geometry of F···HF hydrogen bonds.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 3;241:118677. Epub 2020 Jul 3.

Institute of Chemistry, St. Petersburg State University, 26 Universitetskii pr., Petergof, St. Petersburg 198504, Russia. Electronic address:

In this work applicability of proton donor group stretching vibration force constants k and intermolecular stretching force constants k for evaluations of hydrogen bond strength and geometry are discussed. For a set of 30 complexes with F···HF hydrogen bonds in a wide range 0.5-48 kcal/mol by means of quantum chemical calculations equilibrium geometries, complexation energies, vibrational frequencies and corresponding force constants were calculated (MP2/aug-cc-pVTZ). Read More

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http://dx.doi.org/10.1016/j.saa.2020.118677DOI Listing

Simultaneous determination of cefixime and erdosteine in combined dosage form using validated spectrophotometric methods.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 27;241:118647. Epub 2020 Jun 27.

Researcher, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt.

Four accurate and precise spectrophotometric methods were developed and validated for the simultaneous determination of a binary mixture of cefixime (CEF) and erdosteine (ERD) without previous separation. Method A was first derivative ratio spectrophotometric method (DD) where the amplitudes at 310 and 315 nm and the amplitude at 248 nm were chosen to simultaneously estimate CEF and ERD, respectively. Method B depends on ratio difference spectrophotometry (RDSM), in which the difference in amplitudes at 325 and 326 nm on the ratio spectrum of the mixture was directly proportional to the concentration of CEF; independent of the interfering component. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118647DOI Listing

Caudicles in Vandoid Orchids: A Carotenoid-Based Soft Material with Unique Properties.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

State Key Laboratory of Turbulence and Complex Systems, Department of Mechanics and Engineering Science, BIC-ESAT, College of Engineering, Peking University, Beijing, 100871, People's Republic of China; CAPT, HEDPS and IFSA Collaborative Innovation Center of MoE, Peking University, Beijing, 100871, People's Republic of China. Electronic address:

130 years ago, Darwin observed that caudicles in vandoid orchids possess considerable elasticity and further hypothesized that their elasticity serves to improve pollination efficiency. However, there has been no study that seeks to either quantitatively backup Darwin's hypothesis or characterize this natural material for practical use. Here we show that vandoid caudicles are a novel kind of soft material with extremely high extensibility (1190%), low modulus (160 kPa) and density lower than that of water. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.005DOI Listing

Biomimetic Corneal Stroma Using Electro-Compacted Collagen.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Fairy Meadow, New South Wales, 2519, Australia. Electronic address:

Engineering substantia propria (or stroma of cornea) that mimics the function and anatomy of natural tissue is vital for in vitro modelling and in vivo regeneration. There are, however, few examples of bioengineered biomimetic corneal stroma. Here we describe the construction of an orthogonally oriented 3D corneal stroma model (3D-CSM) using pure electro-compacted collagen (EC). Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.004DOI Listing

Dimerization-Induced Self-Assembly of a Redox-Responsive Prodrug into Nanoparticles for Improved Therapeutic Index.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

The First Affiliated Hospital; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health; School of Medicine, Zhejiang University, Hangzhou, 310003, PR China. Electronic address:

Although some formats of nanomedicines are now available for clinical use, the translation of new nanoparticles to the clinic remains a considerable challenge. Here, we describe a simple yet cost-effective strategy that converts a toxic drug, cabazitaxel, into a safe and effective nanomedicine. The strategy involves the ligation of drug molecules via a self-immolating spacer, followed by dimerization-induced self-assembly to assemble stable nanoparticles. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.007DOI Listing

Remote triggering of TGF-β/Smad2/3 signaling in human adipose stem cells laden on magnetic scaffolds synergistically promotes tenogenic commitment.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal. Electronic address:

Injuries affecting load bearing tendon tissues are a significant clinical burden and efficient treatments are still unmet. Tackling tendon regeneration, tissue engineering strategies aim to develop functional substitutes that recreate native tendon milieu. Tendon mimetic scaffolds capable of remote magnetic responsiveness and functionalized magnetic nanoparticles (MNPs) targeting cellular mechanosensitive receptors are potential instructive tools to mediate mechanotransduction in guiding tenogenic responses. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.009DOI Listing

A full-field 3D Digital Image Correlation and Modelling Technique to Characterise Anterior Cruciate Ligament Mechanics ex vivo.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

School of Engineering, University of Liverpool, Liverpool, L69 3GH, UK; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, UK.

It is limiting to use conventional methods when characterising material properties of complex biological tissues with inhomogeneous and anisotropic structure, such as the anterior cruciate ligament (ACL) in the knee joint. This study aims to develop and utilise a three-dimensional digital image correlation method (3D DIC) for the purpose of determining material properties of femur-ACL-tibia complex across the surface without any contact between the tissue and the loading equipment. A full-field (360° view) 3D DIC test setup consisting of six digital single-lens reflex cameras was developed and ACL specimens from skeletally mature dog knee joints were tested. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.003DOI Listing

Controlled Release of Soy Isoflavones from 3D Printed Bone Scaffolds for Bone Tissue Engineering.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, United States. Electronic address:

Recent challenges in post-surgical bone tumor management have elucidated the need for a multifunctional scaffold, which can be used for residual tumor-cell suppression, defect repair, and simultaneous bone regeneration. In this perspective, 3D printing allows to create a wide variety of patient-specific implant with complex porous architecture and compatible mechanical strength to that of cancellous bone. Here, a multifunctional bone graft substitute is designed by incorporating the three primary soy isoflavones: genistein, daidzein, and glycitein onto a 3D printed (3DP) tricalcium phosphate (TCP) scaffolds with designed pores, endowing them with in vitro chemopreventive, bone-cell proliferating and immune-modulatory potential. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.006DOI Listing

Endogenous Cell Recruitment Strategy for Articular Cartilage Regeneration.

Acta Biomater 2020 Jul 8. Epub 2020 Jul 8.

School of Medicine, Nankai University, Tianjin 300071, PR China; Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA; No. 28 Fuxing Road, Haidian District, Beijing 100853, PR China. Electronic address:

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and tissue engineering techniques are emerging as promising approaches for AC regeneration and repair. Although the use of cell-seeded scaffolds prior to implantation can regenerate and repair cartilage lesions to some extent, these approaches are still restricted by limited cell sources, excessive costs, risks of disease transmission and complex manufacturing practices. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.008DOI Listing

Analytical performance specifications based on the state-of-the-art for the newborn screening.

Clin Chim Acta 2020 Jul 8. Epub 2020 Jul 8.

Quality Department. Biomedical Diagnostic Center. Hospital Clínic of Barcelona. Electronic address:

Introduction: For the measurands of the newborn screening (NBS), there are no analytical performance specifications (APS) available based on the Milan consensus Models. The objective is to provide total error (TE) APS based on the state-of-the-art (SOTA) for the NBS.

Material And Methods: 23,662 results were collected from the Spanish NBS EQA scheme between May 2015 and September 2018. Read More

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http://dx.doi.org/10.1016/j.cca.2020.07.006DOI Listing

Comparison of test performance of commercial anti-SARS-CoV-2 immunoassays in serum and plasma samples.

Clin Chim Acta 2020 Jul 8. Epub 2020 Jul 8.

Department of Clinical Chemistry, University Medicine Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.

Background: For epidemiologic, social and economic reasons, assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection prevalence and immunity are important to adapt decisions to current demands. Hence, immunoassays for detection of anti-SARS-CoV-2 antibodies are introduced rapidly without requiring FDA emergency use authorization approval. Thus, evaluation of test performance predominantly relies on laboratories. Read More

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http://dx.doi.org/10.1016/j.cca.2020.07.007DOI Listing

Harmonization of two hs-cTnI methods based on recalibration of measured quality control and clinical samples.

Clin Chim Acta 2020 Jul 8. Epub 2020 Jul 8.

S.C. Laboratorio Analisi, A.O. Ordine Mauriziano di Torino, Torino, Italy.

Background: The study aim was to evaluate whether is possible to harmonize the results of two hs-cTnI methods using a recalibration procedure based on linear regression models and measured values of external quality assessment (EQA) and clinical samples.

Methods: A two-step experimental approach was used. The preliminary step was performed using 16 EQA samples. Read More

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http://dx.doi.org/10.1016/j.cca.2020.07.009DOI Listing

Interaction of TGFβ3 ligand with its receptors type II (TβRII) and type I (TβRI): A unique mechanism of protein-protein association.

Biochim Biophys Acta Proteins Proteom 2020 Jul 8:140485. Epub 2020 Jul 8.

Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi, India. Electronic address:

The proper orchestration of transforming growth factor beta (TGFβ) mediated signal transduction depends upon a delicate set of interactions between specific ligands and their receptors. Here we present an in-depth profiling of the binding mechanism of TGFβ3 ligand with its type II and type I receptors (TβRII and TβRI) using isothermal titration calorimetry (ITC). Studies were carried out in acidic pH as it has great physiological relevance for TGFβ3 activity. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140485DOI Listing

d-serine regulation of the timing and architecture of the inspiratory burst in neonatal mice.

Biochim Biophys Acta Proteins Proteom 2020 Jul 8:140484. Epub 2020 Jul 8.

Facultad de Química y Biología, Departamento de Biología, Universidad de Santiago de Chile, USACH, PO 9170022, Santiago, Chile. Electronic address:

d-serine, released from mouse medullary astrocytes in response to increased CO levels, boosts the respiratory frequency to adapt breathing to physiological demands. We analyzed in mouse neonates, the influence of d-serine upon inspiratory/expiratory durations and the architecture of the inspiratory burst, assessed by pwelch's power spectrum density (PSD) and continuous wavelet transform (CWT) analyses. Suction electrode recordings were performed in slices from the ventral respiratory column (VRC), site of generation of the respiratory rhythm, and in brainstem-spinal cord (en bloc) preparations, from the C5 ventral roots, containing phrenic fibers that in vivo innervate and drive the diaphragm, the main inspiratory muscle. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140484DOI Listing

Physiopathological roles of vesicular nucleotide transporter (VNUT), an essential component for vesicular ATP release.

Biochim Biophys Acta Biomembr 2020 Jul 8:183408. Epub 2020 Jul 8.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.

Vesicular nucleotide transporter (VNUT) is the last identified member of the SLC17 organic anion transporter family, which plays a central role in vesicular storage in ATP-secreting cells. The discovery of VNUT demonstrated that, despite having been neglected for a long time, vesicular ATP release represents a major pathway for purinergic chemical transmission, which had been mainly attributed to ATP permeation channels. This article summarizes recent advances in our understanding of the mechanism of VNUT and its physiopathological roles as well as the development of inhibitors. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183408DOI Listing

Designing and developing a high-resolution melting technique for accurate identification of Leishmania species by targeting amino acid permease 3 and cytochrome oxidase II genes using real-time PCR and in silico genetic evaluation.

Acta Trop 2020 Jul 8:105626. Epub 2020 Jul 8.

Molecular Systematics Laboratory, Parasitology Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Discrimination, accurate identification, and reliable techniques are required for accurate identification of Leishmania parasites. High-resolution melting (HRM) is recognized as an authentic and exact method. The main objective of this research was optimizing HRM analysis for detecting and screening Leishmania major, Leishmania tropica and mix infections. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105626DOI Listing

Fleas and flea-borne diseases of North Africa.

Acta Trop 2020 Jul 8:105627. Epub 2020 Jul 8.

Aix Marseille Univ, IRD, AP-HM, SSA; VITROME; IHU Méditerranée Infection, Marseille; France. Electronic address:

North Africa has an interesting and rich wildlife including hematophagous arthropods, and specifically fleas, which constitute a large part of the North African fauna, and are recognised vectors of several zoonotic bacteria. Flea-borne organisms are widely distributed throughout the world in endemic disease foci, where components of the enzootic cycle are present. Furthermore, flea-borne diseases could re-emerge in epidemic form because of changes in the vector-host ecology due to environmental and human behaviour modifications. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105627DOI Listing

Iatrogenic nerve injuries: a potentially serious medical and medicolegal problem. About a series of 42 patients and review of the literature.

Acta Neurol Belg 2020 Jul 11. Epub 2020 Jul 11.

Department of Neurosurgery, CHU Liège, Liège, Belgium.

Objective: To analyze the management of iatrogenic nerve injuries (iNI) in 42 patients.

Methods: Retrospective analysis of the charts.

Results: The iNI occurred mostly during a surgical procedure (n = 39), either on a nerve or plexus (n = 13), on bone, joint, vessel or soft tissue (n = 24) or because of malpositioning (n = 2). Read More

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http://dx.doi.org/10.1007/s13760-020-01424-0DOI Listing

Comparison of the effect of whole-body vibration therapy versus conventional therapy on functional balance of patients with Parkinson's disease: adding a mixed group.

Acta Neurol Belg 2020 Jul 11. Epub 2020 Jul 11.

Sports Medicine and Rehabilitation Department, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, México.

Objective: Assess the effect of Whole-Body Vibration (WBV) therapy in functional balance status of Parkinson's disease (PD) patients and compare this to conventional and combined therapy.

Introduction: PD patients experience a decreased mobility, inactivity, and loss of independence as consequence of disturbances in gait, posture, and balance. Rehabilitation therapy is a non-pharmacological way of improving functionality. Read More

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http://dx.doi.org/10.1007/s13760-020-01439-7DOI Listing

High-resolution magnetic resonance imaging for the follow-up of intracranial arterial dissections.

Acta Neurol Belg 2020 Jul 10. Epub 2020 Jul 10.

Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Gojan 1-Dong, Danwon-Gu, Ansan-si, Gyeonggi-Do, 152-703, Republic of Korea.

High-resolution magnetic resonance imaging (HRMRI) with a 3-T system can be utilized to identify intracranial arterial dissections (ICADs) as it reveals more than three key features with better clarity than other conventional imaging modalities. This study aimed to assess the changes in the key features of ICADs on HRMRI over time. We screened patients who had undergone HRMRI within 7 days of symptom onset for the evaluation of characteristics associated with intracranial steno-occlusive lesions. Read More

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http://dx.doi.org/10.1007/s13760-020-01432-0DOI Listing

Evaluation of clinical outcome and safety profile of edaravone in treatment of amyotrophic lateral sclerosis: a 72-week single-center experience.

Acta Neurol Belg 2020 Jul 10. Epub 2020 Jul 10.

Department of Neurology, Ibn Sina Hospital, Gamal Abdel Nasser Street, Sabah Medical Area, Box 25427, 13115, Kuwait City, Kuwait.

Edaravone is a free radical scavenger that has been recently approved for treatment of Amyotrophic lateral sclerosis (ALS) to delay functional decline. We aim to evaluate edaravone efficacy and safety in ALS patients in the main neurology tertiary center in Kuwait over 72-week period. We conducted a prospective observational cohort study in the main tertiary hospital over 72-week period from July 2018 until January 2020. Read More

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http://dx.doi.org/10.1007/s13760-020-01430-2DOI Listing

Predictors of respiratory decline in myotonic dystrophy type 1 (DM1): a longitudinal cohort study.

Acta Neurol Belg 2020 Jul 10. Epub 2020 Jul 10.

Neurology Unit, Department of Biomedical, Metabolic and Neural Sciences, University Hospitals of Modena, Via P. Giardini, 1355, Modena, Italy.

We studied 33 patients affected by juvenile and adult myotonic dystrophy type 1 (DM1). The aim of the study was to assess clinical and laboratory parameters that could predict the requirement of noninvasive ventilation (NIV) in DM1. Secondary outcome was to assess the interplay between genetic profile, muscle impairment severity and presence of cardiac comorbidities. Read More

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http://dx.doi.org/10.1007/s13760-020-01425-zDOI Listing

Cancer immunosensor based on apo and holo transferrin binding.

Mikrochim Acta 2020 Jul 10;187(8):438. Epub 2020 Jul 10.

Chemistry Department, Campus CEDETEG, State University of Midwest Paraná, Guarapuava, Brazil.

An electrochemical immunosensor was developed for the determination of apo-Tf (non-iron-bound) and holo-Tf (iron-bound) using polyclonal antibody transferrin (anti-Tf) immobilized at an electrode surface as a biorecognition platform. The monitoring was based on the anti-Tf binding with both Tf forms which allows the detection of cancer cells due to the constant iron cycle and the overexpression of anti-Tf on the cancer cell surface. The immunosensor characterization was performed using electrochemical impedance spectroscopy (EIS), which evaluated the impedimetric biorecognition of the antigens-antibody by the use of KFe(CN) redox group. Read More

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http://dx.doi.org/10.1007/s00604-020-04420-6DOI Listing

The IDEAL framework in neurosurgery: a bibliometric analysis.

Acta Neurochir (Wien) 2020 Jul 10. Epub 2020 Jul 10.

Department of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.

Background: The Idea, Development, Exploration, Assessment and Long-term study (IDEAL) framework was created to provide a structured way for assessing and evaluating novel surgical techniques and devices.

Objectives: The aim of this paper was to investigate the utilization of the IDEAL framework within neurosurgery, and to identify factors influencing implementation.

Methods: A bibliometric analysis of the 7 key IDEAL papers on Scopus, PubMed, Embase, Web of Science, and Google Scholar databases (2009-2019) was performed. Read More

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http://dx.doi.org/10.1007/s00701-020-04477-5DOI Listing

Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier.

Acta Neuropathol 2020 Jul 11. Epub 2020 Jul 11.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood-brain barrier (BBB) endothelial cells (ECs), astrocytes and microglia for EAE development, using mice with the conditional deletion of its signaling receptor IL-1R1. We found that IL-1 signaling in microglia and astrocytes is redundant for the development of EAE, whereas the IL-1R1 deletion in BBB-ECs markedly ameliorated disease severity. Read More

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http://dx.doi.org/10.1007/s00401-020-02187-xDOI Listing

Desmoplastic Melanoma as a Diagnostic Pitfall.

Acta Dermatovenerol Croat 2020 Jul;28(1):49-50

Dear Editor, Desmoplastic melanoma (DM) is a rare histological subtype of melanoma, usually presenting as a slowly-growing, amelanotic, discoid, and/or firm lesion composed of spindle cells with abundant collagen (1). It is more common on sun-exposed areas, especially on head and neck in elderly patients (2). Regional lymph node involvement is reported to be less frequent than in other cutaneous melanomas (3). Read More

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Tattoo Pigment within Regional Lymph Nodes Mimicking Cutaneous Melanoma Metastasis.

Acta Dermatovenerol Croat 2020 Jul;28(1):47-48

Nikolina Jurišić, MD,

Dear Editor, The diagnosis of malignant melanoma accounts for 1-2% of all cancer diagnoses, around 4% of all malignant skin diseases, and 80% of all skin cancer deaths (1). The prognosis depends on several factors including tumor size, Clark level, Breslow thickness, location, ulceration, and presence of metastases. Detection of lymph node metastasis is initially accomplished by clinical examination and by operative evaluation for occult metastasis using sentinel lymph node biopsy (SLNB) when indicated (2). Read More

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Unusual Case of Granuloma Annulare Associated with Diabetes Mellitus.

Acta Dermatovenerol Croat 2020 Jul;28(1):45-46

Associate Professor Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb , Croatia;

Dear Editor, Granuloma annulare (GA) is an asymptomatic, chronic, and relatively common granulomatous skin condition which presents with annular papules usually slowly progressing into plaques on the extremities and the trunk. It usually presents with non-scaly, erythematous, annular plaques on the distal extremity (1,2). The pathogenesis of GA is still unknown, although a variety of possible factors contributing the disease have been reported, including drugs (3), insect bites, sun exposure, trauma, vaccinations, and viral infections (e. Read More

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Expression of p16 Protein in Cutaneous Basal Cell Carcinoma: Still far from Being Clearly Understood.

Authors:
Vladimir Bartoš

Acta Dermatovenerol Croat 2020 Jul;28(1):43-44

Vladimir Bartoš, MD, Faculty Hospital, Žilina, Slovakia;

Dear Editor, p16INK4a protein (p16) is an important tumor suppressor protein involved in the carcinogenesis of many human malignancies. I have read with interest an article by Donati et al. (1) in this journal, who investigated an expression of p16 and proliferation marker Ki-67 in cutaneous tumors. Read More

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Do Athletes Practicing Outdoors Know and Care Enough About the Importance of Photoprotection?

Acta Dermatovenerol Croat 2020 Jul;28(1):41-42

Prof. Marija Buljan, MD, PhD, Department of Dermatology and Venereology, Sestre milosrdnice University Hospital Centre, Vinogradska 29, 10000 Zagreb, Croatia;

Athletes practicing and competing outdoors are exposed to considerable UV radiation and at an increased risk for the development of UV-related skin conditions, including skin cancer. Risk factors for skin cancer include genetics, immune status, and particularly UV radiation. Independent factors, such as phototype, family or personal history of melanoma, number of nevi, atypical nevi and solar lentigines, as well as sunburn history are also important risk indicators for skin cancer, especially melanoma (1-3). Read More

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Incomplete Schnitzler Syndrome.

Acta Dermatovenerol Croat 2020 Jul;28(1):38-40

Mattias A.S. Henning, MD, Department of Dermatology, Zealand University Hospital, Sygehusvej 5, 4000 Roskilde, Denmark;

Schnitzler syndrome (SS) is a rare autoinflammatory disease that presents with chronic urticaria and monoclonal immunoglobulin (Ig) M or G, accompanied by fever, abnormal bone remodeling, skin biopsy with a neutrophilic dermal infiltrate, leukocytosis, or elevated C-reactive protein. It is usually refractory to antihistamines and immunosuppression. We present a case report of clinical SS without monoclonal Ig with robust response to interleukin-1 inhibitor anakinra. Read More

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Topical Imiquimod for Management of Recurrent Lentigo Maligna Melanoma in Situ.

Acta Dermatovenerol Croat 2020 Jul;28(1):34-37

Professor Igor Bartenjev, MD, PhD, Department of Dermatovenerology, Medical faculty, University of Ljubljana, Pod kostanji 4, 1000 Ljubljana, Slovenia;

Topical imiquimod is a medication approved for the treatment of external genital and perianal warts, actinic keratosis, and superficial basal cell carcinoma. There have also been reports of its successful use in patients with lentigo maligna melanoma in situ. An 80-year-old female patient was diagnosed with lentigo maligna melanoma in situ which was then surgically removed. Read More

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Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report.

Acta Dermatovenerol Croat 2020 Jul;28(1):29-33

Natália Rybárová, MD, Oční klinika FN Brno, Jihlavská 20, 625 00 Brno, Czech Republic;

We report a case of lamellar ichthyosis and sight-threatening complications of cicatricial ectropion in an adult male patient which was surgically managed with tectonic penetrating keratoplasty. We present a case of autosomal-recessive lamellar ichthyosis in a 47-year-old man who was referred to our outpatient eye clinic for treatment of primary keratouveitis of the right eye with keratolysis and exudation in the anterior chamber. A diagnosis of cicatricial ectropion with serious lagophthalmos was established on examination. Read More

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Long-Term Efficacy of Treatment with Intravenous Immunoglobulin in Scleromyxedema.

Acta Dermatovenerol Croat 2020 Jul;28(1):24-28

Katarina Trčko, MD, PhD, Department of Dermatology and Venereal Diseases, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribo,r Slovenia;

Scleromyxedema or generalized lichen myxedematosus is a rare depositional disorder. Diagnostic criteria encompass a generalized papular and sclerodermoid eruption, monoclonal gammopathy (paraproteinemia), most often with G-lambda type immunoglobulin, a characteristic microscopic triad (mucin deposition, fibroblast proliferation, fibrosis), and absence of thyroid disease. Many internal manifestations of scleromyxedema have been described to date, leading to high mortality and morbidity. Read More

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Syphilis and Pharmaceutical Industry Marketing Between the Two World Wars in Croatia.

Acta Dermatovenerol Croat 2020 Jul;28(1):14-23

Martin Kuhar, MD, Division for the History of Medical Sciences, Croatian Academy of Sciences and Arts, Gundulićeva 24/III, 10000 Zagreb, Croatia;

Between the two World Wars, the pharmaceutical industry strengthened its influence within the Croatian medical community. Due to the scarcity of professional biomedical journals in the Croatian language, larger pharmaceutical companies started to publish free promotional journals, magazines, and booklets which quickly became popular. They thus succeeded in creating a broad network of opinion leaders by recruiting physicians as authors, primarily writing on their experiences with application of certain drugs. Read More

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Understanding the Relationship Between Smoking and Hidradenitis Suppurativa.

Acta Dermatovenerol Croat 2020 Jul;28(1):9-13

Joško Miše, MD, Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Šalata 4 , 10000 Zagreb, Croatia;

Hidradenitis suppurativa (HS) is a chronic skin disease affecting hair follicles in intertriginous areas, characterized by deep, recurrent, painful nodules and abscesses, fistulae, sinus tracts, and scarring. With a prevalence of 1-4%, HS is not an uncommon disease. Several risk factors have been linked with the development of HS, such as genetic predisposition, smoking, and obesity, leading to the hypothesis that HS develops as a result of environmental triggers in a genetically susceptible individual. Read More

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Risk Factors for HIV Transmission and HIV Testing Among Medical Students.

Acta Dermatovenerol Croat 2020 Jul;28(1):2-8

Associate Professor Pavel V. Chernyshov, MD, PhD, Department of Dermatology and Venereology, National Medical University, 13 Bulvar Shevchenko, 01601 Kiev, Ukraine;

Risky behavior in students is not infrequent. The prevalence of HIV in Ukraine is one of the highest in Europe. The aim of this study was to investigate risk factors of HIV transmission and prevalence of HIV testing in medical students from Ukraine. Read More

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What a challenging beginning of the year!

Acta Dermatovenerol Croat 2020 Jul;28(1)

At the beginning of the 28th year of the life of our Acta Dermatovenerologica Croatica Journal, we experienced so many challenges which are quite difficult to grasp of and which nobody could predicted in advance. It all began with some vague information from Wuhan about a new virus which was spreading quickly and which eventually led to a lock-down in our country as well. We had hoped that this would not have such a big impact on the life of the Journal, in fact we hoped that may some of our potential authors would have more time to finalize their previous research and send us their manuscripts. Read More

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Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes.

Acta Neuropathol Commun 2020 Jul 10;8(1):105. Epub 2020 Jul 10.

Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, A. Pawińskiego 5 Street, 02-106, Warsaw, Poland.

Four molecular types of rare central nervous system (CNS) tumors have been recently identified by gene methylation profiling: CNS Neuroblastoma with FOXR2 activation (CNS NB-FOXR2), CNS Ewing Sarcoma Family Tumor with CIC alteration (CNS EFT-CIC), CNS high grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1) and CNS high grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR). Although they are not represented in 2016 updated WHO classification of CNS tumors, their diagnostic recognition is important because of clinical consequences. We have introduced a diagnostic method based on transcription profiling of tumor specific signature genes from formalin-fixed, paraffin-embedded tumor blocks using NanoString nCounter Technology. Read More

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http://dx.doi.org/10.1186/s40478-020-00984-9DOI Listing

Endoscopic myringoplasty in pediatric patients: a comparison of cartilage graft push-through and underlay fascia graft techniques.

Authors:
Zhengcai Lou

Acta Otolaryngol 2020 Jul 10:1-6. Epub 2020 Jul 10.

Department of Otorhinolaryngology, Affiliated Yiwu Hospital of Wenzhou Medical University (Yiwu Central Hospital), Yiwu City, China.

Background: Although myringoplasty is performed in pediatric patients, there is still no consensus on the graft material and surgerical procedure.

Objective: To compare the short-and long- term graft take rates of the cartilage push-through and fascia graft techniques employed during pediatric myringoplasty.

Materials And Methods: 93 pediatric patients with perforation who underwent myringoplasty were randomized into the cartilage push-through and underlay fascia graft group. Read More

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http://dx.doi.org/10.1080/00016489.2020.1787510DOI Listing

A near-infrared fluorescent probe for imaging of nitroxyl in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 3;241:118680. Epub 2020 Jul 3.

College of Materials Science and Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, China.

A BODIPY-based NIR fluorescent probe, NitroxylBDP, for the rapid and specific, detection of HNO has been designed and synthesized. The merits of NIR fluorescence, and stable fluorescence output against pH changes, and good membrane permeability, enable the probe to serve as an ideal indicator for tracking HNO in living systems. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118680DOI Listing

A dual thiourea-appended perylenebisimide "turn-on" fluorescent chemosensor with high selectivity and sensitivity for Hg in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118678. Epub 2020 Jul 2.

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Sensing heavy metal ions particularly for the most toxic Hg is a long-term pursuit for chemists because of its obvious and extreme harmfulness to both the environment and human health. Herein, a novel 'turn-on' perylenebisimide-thiourea fluorescent probe PBI-BTB is achieved for rapid detection of Hg in a DMSO/HO (5/1, v/v) solution through a typical Hg-promoting desulfurization reaction, which has been investigated through Job's plot titration, FT-IR, H NMR and HRMS analysis. A remarkable fluorescence emission enhancement at 540 and 580 nm is observed in the presence of Hg, which is visible to the naked eye with high selectivity and sensitivity. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118678DOI Listing
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