4,341 results match your criteria Acta Physiologica Hungarica[Journal]


Regulation of Wnt signaling by physical exercise in the cell biological processes of the locomotor system.

Physiol Int 2019 Mar;106(1):1-20

3 Laboratory of Laser Sports Medicine, College of Physical Education and Sports Science, South China Normal University , Guangzhou, China.

In the past decade, researches on Wnt signaling in cell biology have made remarkable progress regarding our understanding of embryonic development, bone formation, muscle injury and repair, neurogenesis, and tumorigenesis. The study also showed that physical activity can reverse age-dependent decline in skeletal muscle, preventing osteoporosis, regenerative neurogenesis, hippocampal function, cognitive ability, and neuromuscular junction formation, and the age-dependent recession is highly correlated with Wnt signaling pathways. However, how the biological processes in cell and physical activity during/following exercise affect the Wnt signaling path of the locomotor system is largely unknown. Read More

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http://dx.doi.org/10.1556/2060.106.2019.07DOI Listing
March 2019
1 Read

Voluntary wheel running and testosterone replacement increases heart angiogenesis through miR-132 in castrated diabetic rats.

Physiol Int 2019 Mar 25;106(1):48-58. Epub 2019 Mar 25.

4 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences , Khorramabad, Iran.

Objective: Low levels of testosterone in men with diabetes are associated with cardiovascular complications. We investigated the effect of testosterone and voluntary exercise on heart angiogenesis in castrated diabetic rats.

Methods: Sixty-three diabetic rats were treated with testosterone 2 mg/kg/day or voluntary exercise alone or combination of these two for 6 weeks. Read More

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http://dx.doi.org/10.1556/2060.106.2019.06DOI Listing
March 2019
1 Read

Effects of aerobic versus resistance training on serum fetuin-A, fetuin-B, and fibroblast growth factor-21 levels in male diabetic patients.

Physiol Int 2019 Mar 19;106(1):70-80. Epub 2019 Mar 19.

2 Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran.

The aim of this study was to compare the effects of 8 weeks of aerobic versus resistance training programs on serum fetuin-A, fetuin-B, and fibroblast growth factor-21 (FGF-21) levels in males with type 2 diabetes mellitus. Participants (n = 34) were randomly assigned to a resistance training group (RTG; n = 12), an aerobic training group (ATG; n = 11), or a control group (n = 11). The ATG completed 30-45 min of aerobic running training at 65%-75% of the maximum heart rate. Read More

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http://dx.doi.org/10.1556/2060.106.2019.01DOI Listing
March 2019
1 Read

Effect of voluntary exercise on intracellular signalling pathways of angiogenesis in the sciatic nerve of type 1 diabetic castrated male rats.

Physiol Int 2019 Mar 19;106(1):39-47. Epub 2019 Mar 19.

1 Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran.

Objectives: Impaired angiogenesis in sciatic nerve is a major complication of diabetic neuropathy. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play critical roles during capillary-like network formation in the angiogenesis process.

Methods: Twenty-four adult male Wistar rats (weight: 250-300 g) were used in the research. Read More

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http://dx.doi.org/10.1556/2060.106.2019.08DOI Listing
March 2019
5 Reads

The role of astrocytes on the effects of exercise on episodic memory function.

Authors:
P D Loprinzi

Physiol Int 2019 Mar 19;106(1):21-28. Epub 2019 Mar 19.

1 Exercise & Memory Laboratory, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi , University, MS, USA.

This review discusses the potential role that glial cells may play in influencing the relationship between exercise and episodic memory function. A narrative review methodology is employed. Herein, the different types of glial cells, their implications in subserving episodic memory function, and how exercise can modulate glial cell activity, particularly astrocyte functionality, are discussed. Read More

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http://dx.doi.org/10.1556/2060.106.2019.04DOI Listing

Homocysteine-induced inverse expression of tissue factor and DPP4 in endothelial cells is related to NADPH oxidase activity.

Physiol Int 2019 Mar 19;106(1):29-38. Epub 2019 Mar 19.

1 Department of Pathology, Amsterdam UMC, VUmc , Amsterdam, The Netherlands.

Purpose: We previously found that homocysteine (Hcy)-induced apoptosis in endothelial cells coincided with increased NADPH oxidase (NOX) activity. In addition, in ischemic endothelial cells present in the heart, we showed that loss of serine protease dipeptidyl peptidase IV (DPP4) expression was correlated with induction of tissue factor (TF) expression. Since Hcy can initiate thrombosis through the induction of TF expression, in this study, we evaluated whether the inverse relation of TF and DPP4 is also Hcy-dependent and whether NOX-mediated reactive oxygen species (ROS) is playing a role herein. Read More

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http://dx.doi.org/10.1556/2060.106.2019.05DOI Listing

Pycnogenol supplementation as an adjunct treatment for antidepressant-induced sexual dysfunction.

Physiol Int 2019 Mar 19;106(1):59-69. Epub 2019 Mar 19.

6 Clinic of Psychiatry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin , Bratislava, Slovakia.

Introduction: Major depressive disorder is a serious mental disorder in which treatment with antidepressant medication is associated with incidence of adverse events, such as constipation, diarrhea, dry mouth, headache, insomnia, and sexual dysfunction (SDys). Escitalopram (ESC), an effective and safe selective serotonin reuptake inhibitor with good tolerability, was used in this study. In this study, we investigated the prospective effect of Pycnogenol (PYC), an antioxidant, anti-inflammatory, and vasodilator agent, on ESC-induced SDys. Read More

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http://dx.doi.org/10.1556/2060.106.2019.02DOI Listing
March 2019
1 Read

Usefulness of heart rate recovery parameters to monitor cardiovascular adaptation in elite athletes: The impact of the type of sport.

Physiol Int 2019 Mar 19;106(1):81-94. Epub 2019 Mar 19.

4 School of Medicine, University of Belgrade , Belgrade, Serbia.

Purpose: The purpose of this study is to determine heart rate (HR) recovery after maximal test in elite athletes who compete in high dynamic, high static, and in mixed sport disciplines; to assess differences in HR recovery between these groups of athletes; and to measure the association of HR index (HRI) with heart adaptation variables to determine whether these values were correlated with the type of exercise.

Methods: One hundred and ninety-four elite athletes were divided into three groups according to the predominant type of exercise performed: endurance (n = 40), strength-sprinter (n = 36), and ball-game players (n = 118). They performed maximal cardiopulmonary exercise testing on a treadmill and were subjected to echocardiography. Read More

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http://dx.doi.org/10.1556/2060.106.2019.03DOI Listing
March 2019
1 Read

Advances and challenges in geroscience research: An update.

Physiol Int 2018 Dec;105(4):298-308

1 Vascular Cognitive Impairment and Neurodegeneration Program Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center , Oklahoma City, OK, USA.

Aging remains the most pervasive risk factor for a wide range of chronic diseases that afflict modern societies. In the United States alone, incidence of age-related diseases (e.g. Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.32DOI Listing
December 2018
1 Read

Energy expenditure, recovery oxygen consumption, and substrate oxidation during and after body weight resistance exercise with slow movement compared to treadmill walking.

Physiol Int 2018 Dec;105(4):371-385

1 Graduate School of Health and Sports Science, Juntendo University , Chiba, Japan.

The benefit of body weight resistance exercise with slow movement (BWRE-slow) for muscle function is well-documented, but not for energy metabolism. We aimed to examine physiological responses [e.g. Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.27DOI Listing
December 2018

Allantoin improves histopathological evaluations in a rat model of gastritis.

Physiol Int 2018 Dec 23;105(4):325-334. Epub 2018 Dec 23.

3 Student Research Committee, Qom University of Medical Sciences , Qom, Iran.

Purpose: Gastritis is found to be one of the most common gastrointestinal diseases worldwide. However, current therapeutic agents cause side effects, interaction, and recurrence. Allantoin has anti-inflammatory and wound healing properties. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.4.30
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http://dx.doi.org/10.1556/2060.105.2018.4.30DOI Listing
December 2018
8 Reads

Care for chronic renal patients - Role of multidisciplinary education.

Authors:
Á Haris K Polner

Physiol Int 2018 Dec 23;105(4):347-357. Epub 2018 Dec 23.

1 Nephrology Department, Szent Margit Hospital , Budapest, Hungary.

The aim of this study is to summarize the beneficial effects of the holistic approach to patients living with chronic renal failure, including multidisciplinary education and psychosocial care. By education, we enable our patients to reach self-management, appropriate compliance, and coping, which may decrease progression of renal failure, avoid urgent need for starting dialysis and may facilitate better modality selection, access planning, renal transplantation activity, and rehabilitation. Psychosocial care reduces anxiety and fear, modifies perception of illness' burden, and increases quality of life. Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.26DOI Listing
December 2018

Assessment of the impact of 10-day intermittent hypoxia on the autonomic control measured by heart rate variability.

Physiol Int 2018 Dec 19;105(4):386-396. Epub 2018 Dec 19.

1 Department of Pathophysiology, Medical University of Plovdiv , Plovdiv, Bulgaria.

Purpose: The purpose of this study is to establish the alterations in the activity of the autonomic nervous system (ANS) via heart rate variability (HRV) in subjects exposed to 1 h of exogenous hypoxia for 10 consecutive days.

Methods: Twelve healthy non-smoker males at mean age of 29.8 ± 7. Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.31DOI Listing
December 2018

The effects of exhaustive swimming and probiotic administration in trained rats: Oxidative balance of selected organs, colon morphology, and contractility.

Physiol Int 2018 Dec 19;105(4):309-324. Epub 2018 Dec 19.

1 Department of Physiology, Faculty of Veterinary Medicine, Adnan Menderes University , Aydin, Turkey.

The duration and intensity of exercise are significant factors in oxidative, morphological, and functional changes of the gastrointestinal tract. This study aimed to investigate the effects of both exhaustive swimming and probiotic VSL#3 on rats that had been previously trained with moderate swimming. The rats were divided into four groups labeled: control (C), probiotic (P), exercise (E), and probiotic-exercise (PE). Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.25DOI Listing
December 2018

Effect of melatonin ingestion on physical performance, metabolic responses, and recovery after an intermittent training session.

Physiol Int 2018 Dec 18;105(4):358-370. Epub 2018 Dec 18.

5 National Observatory of Sport , Tunis, Tunisia.

Objectives: Fatigue is a limiting factor for sport performance. For this reason, optimal recovery after training is just as critical as the training program itself, if not more. Indeed, there is a need for strategies that can facilitate recovery after training, and one such strategy is the ingestion of supplements like melatonin (MEL). Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.24DOI Listing
December 2018
2 Reads

Integrated central blood pressure-aortic stiffness risk score for cardiovascular risk stratification in chronic kidney disease.

Physiol Int 2018 Dec 17;105(4):335-346. Epub 2018 Dec 17.

3 1st Department of Medicine, Semmelweis University , Budapest, Hungary.

Background And Aims: The aim of this study was to develop an integrated central blood pressure-aortic stiffness (ICPS) risk score to predict cardiovascular events.

Methods: It was a retrospective cohort study. A total of 100 chronic kidney disease (CKD) patients on conservative therapy were included. Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.29DOI Listing
December 2018

Hypothesized mechanisms through which acute exercise influences episodic memory.

Physiol Int 2018 Dec 10;105(4):285-297. Epub 2018 Dec 10.

1 Exercise & Memory Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi , Oxford, MS, USA.

Emerging research demonstrates that exercise is favorably associated with several cognitive outcomes, including episodic memory function. The majority of the mechanistic work describing the underlying mechanisms of this effect has focused on chronic exercise engagement. Such mechanisms include, e. Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.28DOI Listing
December 2018
1 Read

Prenatal hypoxia-ischemia decreases spatial memory and increases aggression during adolescence.

Physiol Int 2018 09;105(3):210-224

1 Faculty of Medicine, Public Health, and Nursing, Department of Physiology, Universitas Gadjah Mada , Yogyakarta, Indonesia.

Prenatal hypoxia-ischemia (HI) is a major cause of mortality and chronic neurological diseases in newborns. HI contributes to the emergence of several neurological disorders such as cognitive and behavioral deficits due to the atypical brain development. This study aimed at assessing the effects of prenatal HI on the spatial memory and aggression of rats during adolescence. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.3.21
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http://dx.doi.org/10.1556/2060.105.2018.3.21DOI Listing
September 2018
5 Reads

Protective effects of quercetin from oxidative/nitrosative stress under intermittent hypobaric hypoxia exposure in the rat's heart.

Physiol Int 2018 09;105(3):233-246

1 Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca, Romania.

Background: Exposure to high altitude in hypobaric hypoxia (HH) is considered to be a physiological oxidative/nitrosative stress. Quercetin (Que) is an effective antioxidant and free radical scavenger against oxidative/nitrosative stress.

Aims: The aim of this study was to investigate the cardioprotective effects of Que in animals exposed to intermittent HH (IHH) and therefore exposed to oxidative/nitrosative stress. Read More

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http://dx.doi.org/10.1556/2060.105.2018.3.23DOI Listing
September 2018
1 Read

The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells.

Physiol Int 2018 09 1;105(3):247-256. Epub 2018 Oct 1.

1 Department of Health, Exercise, and Sports Sciences, University of New Mexico , Albuquerque, NM, USA.

Autophagy is a lysosome degradation pathway through which damaged organelles and macromolecules are degraded within the cell. A decrease in activity of the autophagic process has been linked to several age-associated pathologies, including triglyceride accumulation, mitochondrial dysfunction, muscle degeneration, and cardiac malfunction. Here, we examined the differences in the autophagic response using autophagy-inducer rapamycin (Rapa) in peripheral blood mononuclear cells (PBMCs) from young (21. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.3.20
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http://dx.doi.org/10.1556/2060.105.2018.3.20DOI Listing
September 2018
6 Reads

Lower occlusion pressure during resistance exercise with blood-flow restriction promotes lower pain and perception of exercise compared to higher occlusion pressure when the total training volume is equalized.

Physiol Int 2018 09 1;105(3):276-284. Epub 2018 Oct 1.

1 MUSCULAB - Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos - UFSCar , São Carlos, Brazil.

Low-intensity resistance exercise with blood-flow restriction (BFR) promotes similar adaptations to high-intensity resistance exercise (HI-RE). Interestingly, BFR has been demonstrated to be effective for a wide range of occlusion pressures. However, the occlusion pressure magnitude may alter the psychophysiological stress related to BFR as measured by rating of perceived exertion scale (RPE) and rating of pain. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.3.18
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http://dx.doi.org/10.1556/2060.105.2018.3.18DOI Listing
September 2018
1 Read

The modulation of ureteral smooth muscle contractile responses by α- and α-adrenoceptor activation.

Authors:
D R Monks S J Bund

Physiol Int 2018 09 1;105(3):225-232. Epub 2018 Oct 1.

1 UCD School of Medicine, Health Sciences Centre, University College Dublin , Dublin, Ireland.

Purpose: This study was performed to investigate the influence of α-adrenoceptor subtypes upon ureteral smooth muscle contractile responses.

Methods: Rat ureters were challenged in vitro with noradrenaline (NA), the α-adrenoceptor agonist phenylephrine (PE), and the α-adrenoceptor agonist clonidine (CLON). The influences of the agonists on the magnitude and frequency of acetylcholine (ACh)-stimulated phasic contractile responses were recorded. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.3.19
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http://dx.doi.org/10.1556/2060.105.2018.3.19DOI Listing
September 2018
1 Read

Effects of side-dominance on knee joint proprioceptive target-matching asymmetries.

Physiol Int 2018 09 1;105(3):257-265. Epub 2018 Oct 1.

1 Pain Clinic , Budapest, Hungary.

Aims: Right- and left-side-dominant individuals reveal target-matching asymmetries between joints of the dominant and non-dominant upper limbs. However, it is unclear if such asymmetries are also present in lower limb's joints. We hypothesized that right-side-dominant participants perform knee joint target-matching tasks more accurately with their non-dominant leg compared to left-side-dominant participants. Read More

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http://dx.doi.org/10.1556/2060.105.2018.3.22DOI Listing
September 2018
1 Read

Physiological adaptations to specific endurance training in professional female handball players.

Physiol Int 2018 09 19;105(3):266-275. Epub 2018 Jul 19.

1 Faculty of Pedagogy and Psychology, Department of Sport Sciences, Eötvös Loránd University , Szombathely, Hungary.

Several Hungarian and foreign researchers have already studied the cardiorespiratory parameters of elite handball players. There are only a few studies though, which would separately review the changes in the functions of different organ systems. The aim of this study is to investigate the effect of an intervention (physical activity) on the cardiorespiratory system. Read More

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http://dx.doi.org/10.1556/2060.105.2018.2.12DOI Listing
September 2018
5 Reads

Arterial stiffness may predict renal and cardiovascular prognosis in autosomal-dominant polycystic kidney disease.

Physiol Int 2018 Jun;105(2):145-156

1 2nd Department of Internal Medicine and Nephrological Centre, Clinical Centre, Medical School, University of Pécs , Pécs, Hungary.

Background and aims Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common causes of end-stage renal disease (ESRD). The most important cause of death among ADPKD patients is cardiovascular (CV). The aim of this study was to examine the prognostic significance of arterial stiffness on CV and renal outcomes in ADPKD. Read More

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http://dx.doi.org/10.1556/2060.105.2018.2.17DOI Listing
June 2018
5 Reads

Sitting to standing postural changes: Energy expenditure and a possible mechanism to alleviate sedentary behavior.

Physiol Int 2018 Jun;105(2):157-165

1 Faculty of Sports Science, Ningbo University , Ningbo, China.

Background and aims Sedentary lifestyles have recently been identified as potential mechanism for obesity and associated metabolic diseases linked to ill health. The aim of this study was to investigate the effects of standing and sitting-standing positional changes on energy cost and consequently interrupting sedentary sitting time while working. Methods A total of 26 healthy male volunteers performed normal typing and editing work for 100 min under three conditions. Read More

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http://dx.doi.org/10.1556/2060.105.2018.2.14DOI Listing
June 2018
14 Reads

Effects of submaximal cycling at different exercise intensities on maximal isometric force output of the non-exercised elbow flexor muscles.

Physiol Int 2018 Jun;105(2):177-187

4 Faculty of Liberal Studies, National Institute of Technology, Kumamoto College , Koshi, Japan.

The purpose of this study was to examine the effects of submaximal cycling at different exercise intensities on maximal isometric force output of the non-exercised elbow flexor muscles after the cycling. A total of 8 healthy young men performed multiple maximal voluntary contractions by the right elbow flexion before, immediately after, 5 min after, and 10 min after a 6-min submaximal cycling at ventilatory threshold (LI), 70% [Formula: see text] (MI), and 80% [Formula: see text] (HI) with both arms relaxed in the air. Force and surface electromyogram (EMG) of the right biceps brachii muscle during the multiple MVCs, blood lactate concentration ([La]), cardiorespiratory responses, and sensations of fatigue for legs (SEF-L) were measured before, immediately after, 5 min after, and 10 min after the submaximal cycling with the three different exercise intensities. Read More

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http://dx.doi.org/10.1556/2060.105.2018.2.13DOI Listing
June 2018
4 Reads

Effect of one bout of local vibration exercise with blood flow restriction on neuromuscular and hormonal responses.

Physiol Int 2018 Jun;105(2):166-176

4 Division of Physical and Health Education, Center for General Education, National Sun Yat-sen University , Kaohsiung City, Taiwan.

This study aimed to investigate the effects of single local vibration (LV) with and without blood flow restriction (BFR) on muscle activity and hormonal responses. A total of 12 physically inactive males were exposed to 10 sets of intermittent LV (35-40 Hz) on unilateral mid-quadriceps in the supine lying position and LV + BFR (inflated to 140 mmHg) sessions in a repeated-measures randomized crossover design, with a 1-week interval separating the sessions. The results indicated that the electromyography values from the rectus femoris during LV + BFR were greater than those during LV (p < 0. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.2.9
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http://dx.doi.org/10.1556/2060.105.2018.2.9DOI Listing
June 2018
7 Reads

The immune system cell populations were increased in salt-induced hypertensive rats without an increase in the serum testosterone level (Short communication).

Physiol Int 2018 Jun;105(2):110-115

1 Faculty of Basic Medical Sciences, Department of Physiology, College of Medicine, University of Lagos , Lagos, Nigeria.

The consumption of dietary salt has significantly increased globally, especially in the developed countries. High dietary salt intake has been linked to onset and complications in hypertension with a dimorphism tendency. There is scanty information about the influence of high salt diet on the immune cell population and androgen level in circulation. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.2.16
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http://dx.doi.org/10.1556/2060.105.2018.2.16DOI Listing
June 2018
1 Read

Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats.

Physiol Int 2018 Jun;105(2):116-126

1 Neuroscience Research Center (NSRC), Tabriz University of Medical Sciences , Tabriz, Iran.

Behavioral disturbances are observed in most patients suffering from diabetes. According to some evidence, pro-inflammatory cytokines have a key role both in diabetes and behavioral disorders, such as anxiety and depression. In this study, the effect of chronic administration of loganin, as a bioflavonoid, was investigated on pro-inflammatory cytokines and depression- and anxiety-like behaviors in streptozotocin-induced diabetes in male Wistar rats. Read More

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http://dx.doi.org/10.1556/2060.105.2018.2.8DOI Listing
June 2018
1 Read

The affective and behavioral responses to repeated "strength snacks".

Physiol Int 2018 Jun;105(2):188-197

1 Department of Health, Exercise Science, and Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi , University, MS, USA.

Background A training program consisting of only one-repetition maximum (1RM) training results in similar strength adaptations as traditional resistance exercise. However, little is known regarding the affective or behavioral responses to this type of training. Aim To examine the affective and behavioral response to either a traditional resistance exercise program or a biweekly 1RM-training program. Read More

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http://dx.doi.org/10.1556/2060.105.2018.2.15DOI Listing

Should we really STOP treating patients with IgA nephropathy with steroids?

Physiol Int 2018 Jun;105(2):101-109

2 Department of Nephrology and Dialysis, Ospedale Maggiore Policlinico , Milan, Italy.

IgA nephropathy (IgAN) is the most common primary glomerulonephritis all over the world. Once considered as a benign disease, today the scientific community is aware that a significant percentage of patients eventually progress to end-stage kidney disease (ESKD). The rate of progression is often very slow. Read More

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https://www.akademiai.com/doi/10.1556/2060.105.2018.2.10
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http://dx.doi.org/10.1556/2060.105.2018.2.10DOI Listing
June 2018
2 Reads

Effects of low dose of aliskiren on isoproterenol-induced acute myocardial infarction in rats.

Physiol Int 2018 Jun;105(2):127-144

4 Internal Medicine Department, Delta University for Science and Technology , Gamasa, Egypt.

This study examined the effects of aliskiren (Ali) (direct renin inhibitor) on serum cardiac enzymes (LDH and CK-MB), electrocardiography (ECG) changes, myocardial oxidative stress markers (MDA, CAT, and GSH) and the expression of Bcl2, HO-1, and Nrf2 genes in isoproterenol (ISO)-induced myocardial infarction (MI). A total of 40 male albino rats were allocated into four groups, (1) normal control (NC) group, (2) Ali group (rats received Ali at 10 mg/kg/day p.o. Read More

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http://dx.doi.org/10.1556/2060.105.2018.2.11DOI Listing
June 2018
3 Reads

Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats.

Physiol Int 2018 09 1;105(3):199-209. Epub 2018 Jun 1.

1 Neuroscience Research Center (NSRC), Tabriz University of Medical Sciences , Tabriz, Iran.

Behavioral disturbances are observed in most patients suffering from diabetes. According to some evidence, pro-inflammatory cytokines have a key role both in diabetes and behavioral disorders, such as anxiety and depression. In this study, the effect of chronic administration of loganin, as a bioflavonoid, was investigated on pro-inflammatory cytokines and depression- and anxiety-like behaviors in streptozotocin-induced diabetes in male Wistar rats. Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.8DOI Listing
September 2018
6 Reads

Moderate hypothermia and responses to calcium channel blockers - Role of the nitric oxide.

Physiol Int 2018 Mar;105(1):53-60

1 Meram Faculty of Medicine, Department of Medical Pharmacology, Necmettin Erbakan University , Konya, Turkey.

Moderate hypothermia (25-31 °C) may have a significant influence on vascular tone. At present, very little is known about the role of endothelial nitric oxide on the hypothermia-induced responses. In this study, we investigated the effect of hypothermia (to 28 °C) on the vasodilatation induced by verapamil, a phenylalkylamine calcium channel blocker (10-3 × 10 M) and dihydropyridines, amlodipine (10-3 × 10 M), and benidipine (10-10 M) on 5-hydroxytryptamine (5-HT or serotonin) precontracted calf cardiac veins. Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.2DOI Listing
March 2018
1 Read

Melatonin ameliorates brain oxidative stress and upregulates senescence marker protein-30 and osteopontin in a rat model of vascular dementia.

Physiol Int 2018 Mar;105(1):38-52

2 Faculty of Medicine, Department of Medical Physiology, Mansoura University , Mansoura, Egypt.

The aim of this study was to investigate the effect of melatonin on oxidative stress and senescence marker protein-30 (SMP30) as well as osteopontin (OPN) expression in the hippocampus of rats subjected to vascular dementia (VD). A total of 72 male rats were divided into six groups (n = 12 each) as follows: (i) untreated control (CON), (ii) sham-operated group, (iii) sham-operated + melatonin, (iv) rats exposed to VD induced by permanent bilateral occlusion of the common carotid arteries (BCCAO) leading to chronic cerebral hypoperfusion, (v) rats exposed to VD + melatonin, and (vi) rats exposed to VD + donepezil (DON). At the end of experiment, the hippocampal levels of acetylcholine (ACh), norepinephrine (NE), and dopamine (Dop) were measured. Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.1DOI Listing

Swimming exercise demonstrates advantages over running exercise in reducing proteinuria and glomerulosclerosis in spontaneously hypertensive rats.

Physiol Int 2018 Mar;105(1):76-85

1 Department of Biological Sciences (DECBI), Federal University of Ouro Preto , Minas Gerais, Brazil.

Experimental studies in animal models have described the benefits of physical exercise (PE) to kidney diseases associated with hypertension. Land- and water-based exercises induce different responses in renal function. Our aim was to evaluate the renal alterations induced by different environments of PE in spontaneously hypertensive rats (SHRs). Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.7DOI Listing

Heat shock proteins and cardiovascular disease.

Physiol Int 2018 Mar;105(1):19-37

2 Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus , Aurora, CO, USA.

The development of stress drives a host of biological responses that include the overproduction of a family of proteins named heat shock proteins (HSPs), because they were initially studied after heat exposure. HSPs are evolutionarily preserved proteins with a high degree of interspecies homology. HSPs are intracellular proteins that also have extracellular expression. Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.4DOI Listing
March 2018
4 Reads

Surface electromyographic evaluation of the neuromuscular activation of the inspiratory muscles during progressively increased inspiratory flow under inspiratory-resistive loading.

Physiol Int 2018 Mar;105(1):86-99

2 Department of Emergency and Critical Care Medicine, Graduate School of Medicine, University of the Ryukyus , Okinawa, Japan.

This study aimed to evaluate neuromuscular activation in the scalene and sternocleidomastoid muscles using surface electromyography (EMG) during progressively increased inspiratory flow, produced by increasing the respiratory rate under inspiratory-resistive loading using a mask ventilator. Moreover, we attempted to identify the EMG inflection point (EMG) on the graph, at which the root mean square (RMS) of the EMG signal values of the inspiratory muscles against the inspiratory flow velocity acceleration abruptly increases, similarly to the EMG anaerobic threshold (EMG) reported during incremental-resistive loading in other skeletal muscles. We measured neuromuscular activation of healthy male subjects and found that the inspiratory flow velocity increased by approximately 1. Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.3DOI Listing

What we do and do not know about women and kidney diseases; Questions unanswered and answers unquestioned: Reflection on World Kidney Day and International Woman's Day.

Physiol Int 2018 Mar;105(1):1-18

8 Division of Nephrology, Department of Medicine, The University of British Columbia , Vancouver, BC, Canada.

Chronic kidney disease (CKD) affects approximately 10% of the world's adult population; it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.6DOI Listing
March 2018
1 Read

Effect of iloprost on contractile impairment and mitochondrial degeneration in ischemia-reperfusion of skeletal muscle.

Physiol Int 2018 Mar;105(1):61-75

5 Faculty of Medicine, Department of Biostatistics, Mersin University , Mersin, Turkey.

Purpose Acute lower extremity ischemia is still a main cause of mortality and morbidity in orthopedic traumatology and reconstructive surgery. In acute lower extremity ischemia, the skeletal muscles are the tissues that are the most vulnerable to ischemia. The aim of this study was to evaluate the effects of iloprost (IL) therapy on skeletal muscle contractile impairment and mitochondrial degeneration in an acute lower extremity ischemia-reperfusion rat model. Read More

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http://dx.doi.org/10.1556/2060.105.2018.1.5DOI Listing

Biochemical status, oxidative and antioxidant responses after 3-month specific training in elite karate athletes.

Physiol Int 2017 Dec;104(4):344-354

1 Research Unit of Functional Neurophysiology and Pathology, Biology Department, Faculty of Sciences Tunis, University of Tunis El Manar , Tunis, Tunisia.

Aim To investigate the effects of 3-month-long specific training program on biochemical status, oxidative and antioxidant responses in elite karatekas. Methods Twenty male karatekas [BMI: 21.9 ± 2. Read More

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http://dx.doi.org/10.1556/2060.104.2017.4.5DOI Listing
December 2017
3 Reads

Post-transplantation morphological and functional changes in kidneys from expanded criteria donors.

Physiol Int 2017 Dec;104(4):329-333

1 Faculty of Medicine, Department of Surgery, University of Szeged , Szeged, Hungary.

Introduction Despite an increase in the number of cadaver donors and overall organ transplantations, the dramatic increase in the waiting list makes it necessary to reconsider donor criteria. The authors wanted to examine whether differences could exist in the function and/or morphology of transplanted kidneys originated from expanded criteria donors (ECDs) and ideal donors 1 and 5 years after transplantation. Methods Kidney function and histopathologic findings were analyzed and compared 1 and 5 years after transplantation in 97 patients having ECD kidneys and in 178 patients who received ideal donor kidneys (IDK). Read More

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http://dx.doi.org/10.1556/2060.104.2017.4.4DOI Listing
December 2017

Environmental enrichment improved cognitive deficits more in peri-adolescent than in adult rats after postnatal monosodium glutamate treatment.

Physiol Int 2017 Dec;104(4):271-290

2 Department of Neurophysiology, National Institute of Mental Health and Neurosciences , Bangalore, India.

Exposure to enriched environment (EE) is known to promote sensory, cognitive, and motor stimulation with intensified levels of novelty and complexity. In this study, we investigated the positive regulatory effect of short-term exposure to EE on establishing functional recovery in monosodium glutamate (MSG)-induced obese rats. Unless treated, MSG rats exhibited peripheral insulin resistance, cognitive deficits, and a reduction in the total hippocampal volume with decreased neuron count in the DG, CA3, and CA1 subfields. Read More

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http://dx.doi.org/10.1556/2060.104.2017.4.7DOI Listing
December 2017
7 Reads

The effect of nasal provocation with a single-dose allergen on the physical and cognitive performance of patients with ragweed allergy.

Physiol Int 2017 Dec;104(4):334-343

1 Department of Oto-Rhino-Laryngology and Head-Neck Surgery, University of Szeged , Szeged, Hungary.

Purpose This study aims to compare the impact of active allergic rhinitis on physical and cognitive abilities of trained allergic athletes to untrained allergic patients. Methods Cognitive, respiratory, and fitness functions were assessed before and after allergen exposure. Participants in both groups were provoked intranasally with ragweed allergen. Read More

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http://dx.doi.org/10.1556/2060.104.2017.4.6DOI Listing
December 2017

The influence of aging on the effectiveness of heat stress in preventing disuse muscle atrophy.

Physiol Int 2017 Dec;104(4):316-328

1 Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki, Japan.

This study examined the aging effect on disuse muscle atrophy prevention using heat stress. Wistar rats aged 7 and 60 weeks were divided into three groups as follows: control, immobilized (Im), and immobilized and heat stressed (ImH). Heat stress was given by immersing the hindlimbs in hot water (42 °C) for 60 min, once in every 3 days and the gastrocnemius (GAS) and soleus (SOL) muscles were extracted after 14 days. Read More

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http://dx.doi.org/10.1556/2060.104.2017.4.1DOI Listing
December 2017
5 Reads

Curcumin regulates intracellular calcium release and inhibits oxidative stress parameters, VEGF, and caspase-3/-9 levels in human retinal pigment epithelium cells.

Physiol Int 2017 Dec;104(4):301-315

1 Department of Ophthalmology, Haydarpasa Numune Research and Training Hospital , Istanbul, Turkey.

In this study, we aimed to observe whether curcumin (cur), a polyphenolic compound derived from the dietary spice turmeric, a yellow substance obtained from the root of the plant Curcuma longa Linn, has any protective effect against blue light irradiation in human retinal pigment epithelium (ARPE-19) cells. For this purpose, we evaluated the intracellular calcium release mechanism, poly ADP ribose polymerase (PARP), procaspase-3/-9 protein expression levels, caspase activation, and reactive oxygen species levels. ARPE-19 cells were divided into four main groups, such as control, cur, blue light, and cur + blue light. Read More

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http://dx.doi.org/10.1556/2060.104.2017.4.3DOI Listing
December 2017
5 Reads

Effect of α-tocopherol megadoses on hematologic parameters and antioxidant capacity of rats in an ultraendurance probe.

Physiol Int 2017 Dec;104(4):291-300

4 Faculty of Pharmacy, Department of Physiology, University of Granada , Granada, Spain.

This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0. Read More

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http://dx.doi.org/10.1556/2060.104.2017.4.2DOI Listing
December 2017
5 Reads

Vitamin-caused faulty perinatal hormonal imprinting and its consequences in adult age.

Authors:
G Csaba

Physiol Int 2017 Sep;104(3):217-225

1 Department of Genetics, Cell and Immunobiology, Semmelweis University , Budapest, Hungary.

Lipid-soluble vitamins (vitamins A, D, E, and K) are actually hormones (exohormones), as they can be directly bound by hormone receptors or are in connection with molecules, which influence hormone receptors. Vitamin D is a transition between endo- and exohormones and the possibility of similar situation in case of other lipid-soluble hormones is discussed. The perinatal exposition with these "vitamins" can cause faulty perinatal hormonal imprinting with similar consequences as the faulty imprinting by the synthetic endohormones, members of the same hormone family or industrial, communal, or medical endocrine disruptors. Read More

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http://dx.doi.org/10.1556/2060.104.2017.3.5DOI Listing
September 2017
5 Reads