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Acta Physiol Acad Sci Hung 1982 ;60(4):243-9

The effects of intracerebroventricular administration of two different cholecystokinin antisera were tested on acquisition and extinction of active avoidance behaviour as well as on acquisition, maintenance and extinction of conditioned feeding behaviour of rats. Both antisera delayed the extinction of active avoidance and conditioned feeding response, while they were ineffective on acquisition and maintenance. These data suggest that the endogenous CCK of the brain might be a physiological modulator of extinction processes. Read More

Acta Physiol Acad Sci Hung 1982 ;60(4):183-8

The regulation of Na+ and water metabolism was studied in sheep with rumen fistula after water deprivation for 48 hours. Na+ and K+ concentrations were determined in blood plasma, blood, urine and saliva, with or without NaCl load. The results showed that the water content of the ruminal fluid plays an important role in the control of electrolyte and water metabolism. Read More

Acta Physiol Acad Sci Hung 1982 ;60(4):175-81

Differential distribution of gross, particulate and soluble forms of hexokinase in the cerebrum, cerebellum, pituitary, hypothalamus and thalamus and medulla oblongata was studied in 9 inland teleosts of different phylogenetic age to clarify the compartmentation of glucose metabolism. Enzyme activity (gross) was maximum in the cerebrum and minimum in the medulla oblongata, suggesting that glucose metabolism is more intensive in the former structure. The activity in the particulate fraction was highest in the cerebellum followed by the cerebrum, midbrain and medulla oblongata. Read More

Acta Physiol Acad Sci Hung 1982 ;60(3):139-42

Sulfhydryl substances (cysteine, glutathione, cysteamine and BAL) provide protection against experimental gastric ulcer induced by indomethacin while being ulcerogenous in stress-ulcer. Experimental data indicate the necessity to distinguish between "real" and "occasional" cytoprotective drugs. Read More

Acta Physiol Acad Sci Hung 1982 ;60(3):135-8

In the experiments presented here, serum samples were collected both from psoriatic (PS) (n = 8) and non-psoriatic (NPS) patients (n = 8) and were analyzed by the combination of fractional precipitation (80% ethanol, pH 2) and gel filtration techniques as well as by chemical methods. It was demonstrated that, in comparison to the non psoriatic samples, concentration of the free alfa-amino group bearing and the Lowry positive components as well as total carbohydrate content was significantly elevated in the acidic ethanol soluble serum fraction of psoriatic samples. In psoriasis, the quantity of serum components with UV light absorbing capability at 206 nm, and with a molecular mass between 0. Read More

Acta Physiol Acad Sci Hung 1982 ;60(3):129-34

A number of changes in peptide components could be demonstrated in sera of patients with end stage malignant diseases. Total and free alfa amino-N content of such sera was shown to be significantly higher than those in sera of patients with no sign of malignancy. In addition, a significant increase was found in one of the serum fraction obtained by Sephadex G-25 chromatography. Read More

Acta Physiol Acad Sci Hung 1982 ;60(3):121-7

The effect of native serum samples from schizophrenic and control patients on the electrically induced contractions of the isolated mouse vas deferens (MVD) preparations was investigated. It was demonstrated that only the samples of schizophrenic origin elicited a naloxone dependent inhibition on the contractions of the MVD preparations, while sera from healthy individuals and those from non schizophrenic but mentally ill patients proved to be ineffective in this respect. By using ultrafiltration and gel chromatographic techniques, four fractions disclosing MVD related biological activity could be separated from schizophrenic samples. Read More

Acta Physiol Acad Sci Hung 1982 ;60(3):107-19

Arterial blood pressure (BP) and heart rate (HR) were continuously recorded during lateral hypothalamic self-stimulation with optimal stimulus parameters in rats. Hyper-hypotensive, hypertensive and hypotensive reactions were observed during separate self-stimulation, and the biphasic type considerably prevailed over other types of reactions. During the single cycles of self-stimulation hyper-hypotensive and hypertensive reactions with different heart rate reactions also occurred. Read More

Acta Physiol Acad Sci Hung 1982 ;60(1-2):83-8

Three fractions were isolated from the venom of Dendroaspis angusticeps by column chromatography on CM-Sephadex C-25. All the three fractions were shown to possess acetylcholinesterase inhibiting activity. The toxicity of the fractions as tested on mice were variable. Read More

Acta Physiol Acad Sci Hung 1982 ;60(1-2):75-81

Acta Physiol Acad Sci Hung 1982 ;60(1-2):65-74

The escape of radioiodinated serum albumin (RISA) from the circulation and lymphatic albumin transport was investigated in anaesthetized rabbits. The fraction of RISA escaping each hour from the circulation was 0.0932 +/- 0. Read More

Acta Physiol Acad Sci Hung 1982 ;60(1-2):27-35

In acute immobilized rats, the effect on the EEG of thermal and chemical (capsaicin microinjection) stimulation of the warm sensors in the preoptic region, mid-hypothalamic area and posterior hypothalamus were studied. Both localized heating and capsaicin resulted in a sleep-like EEG with spindles and slow waves. Stimulation of the posterior hypothalamus was the most effective and stimulation in the mid-hypothalamus was the least effective in inducing spindle activity. Read More

Acta Physiol Acad Sci Hung 1982 ;60(1-2):1-8

The new total herbicide Toxurazine was subjected to general toxicologic and neurotoxicologic examinations. Rats were treated with 1/80, 1/40 and 1/20 of the acute oral LD50 for three months. The animals showed a decrease in body weight and a transitional anaemia. Read More

Acta Physiol Acad Sci Hung 1982 ;59(1):89-97

The effects of lithocholic acid (LCA), chenodeoxycholic acid (CDCA), deoxycholic acid (DOCA), cholic acid (CA) and dehydrocholic acid (DHCA) on the biliary excretion of amaranth (AM) in rats and on the respiration of isolated liver mitochondria were investigated. Bile acids diminished the biliary excretion of AM, and in vitro they enhanced the state 4 mitochondrial respiration and inhibited DNP- and ADP-stimulated oxygen consumption. The ID50 values (mumol/kg i. Read More

Acta Physiol Acad Sci Hung 1982 ;59(1):75-88

Following stimulation with NaCl of different concentrations, responses from one, two or three receptor cells of the sensillae could be recorded, one of them being always "dominant". The other one or two secondary cells showed a lower frequency and a faster adaptation. The responses of the dominant cells proved to be variable, even to repeated stimulations using the same concentration of the same substance. Read More

Acta Physiol Acad Sci Hung 1982 ;59(1):59-73

Acta Physiol Acad Sci Hung 1982 ;59(1):45-58

The present studies were designed to monitor metabolic perturbations following changes in contractile activity and ion transport in rat and rabbit myometrium by simultaneous measurement of NADH fluorescence, lactate production and isometric force. Stimulation (127 mM K+) and inhibition (Ca2+-deficient solution) of isometric force development induced a decrease/increase of fluorescence intensity corresponding to a more oxidized/reduced state of tissue pyridine nucleotides, respectively. If tension development was abolished by EGTA, fluorescence changes due to altered ion transport could be monitored. Read More

Acta Physiol Acad Sci Hung 1982 ;59(1):35-43

Acta Physiol Acad Sci Hung 1982 ;59(1):29-34

Acta Physiol Acad Sci Hung 1982 ;59(1):15-27

In the rabbit hindleg lymph and tissue fluid were collected before and during close intraarterial infusions of histamine (2.5 and 10 micrograms/min) or bradykinin (0.4 microgram/min). Read More

Acta Physiol Acad Sci Hung 1982 ;59(4):373-86

Acta Physiol Acad Sci Hung 1982 ;59(4):359-71

Acta Physiol Acad Sci Hung 1982 ;59(4):349-58

This paper reports on partial purification and characterization of a natural (endogenous) factor capable of inhibiting in vivo DNA synthesis in mouse pneumocytes in a tissue-specific manner. By using a combination of ultrafiltration and various chromatographic techniques, the active agent has been partially purified from aqueous extracts of both bovine and rat pulmonary tissue. The factor responsible for the observed effect was found to be a heat labile compound, most likely a protein of approx. Read More

Acta Physiol Acad Sci Hung 1982 ;59(4):341-7

The effect of mazindol on feeding behaviour was investigated in rats fasted for 24 hours. They were then given mazindol i.p. Read More

Acta Physiol Acad Sci Hung 1982 ;59(4):325-8

Amniotic fluid was collected from women in the 2nd trimester of their gravidity by amniocentesis and its effect on the isolated pregnant rat uterine preparation investigated. It was demonstrated that some of the amniotic fluid components partially purified by using the combination of various separation techniques stimulated, while others inhibited the contractions of the isolated rat uterine preparation. The inhibitory component, called utero-inhibin also inhibited the spontaneous contractions as well as the basal tone of the isolated rat intestinal preparation and those of the isolated human pregnant myometrium preparation. Read More

Acta Physiol Acad Sci Hung 1982 ;59(4):317-24

Solvents were tested for their influence on motivational state, as well as for their sedative effects, after intraperitoneal administration. The following tests were used: open field (exploratory activity, locomotion), activity wheel (running activity), tube test and tilted plane (muscle weakness, incoordination). The agents proved to be similar in causing muscle weakness and ataxia already at low dose levels. Read More

Acta Physiol Acad Sci Hung 1982 ;59(4):311-5

Hypotonic haemolysis of newborn and adult human red blood cells (RBC) is more intensive at 4 than at 37 degrees C. Newborn RBC are more resistant to the decrease of temperature than adult RBC. Transition temperature of the RBC membrane can well be determined by illustrating osmotic haemolysis as a function of temperature. Read More

Acta Physiol Acad Sci Hung 1982 ;59(4):297-303

The possibility of local recording of the electrical activity of the sinus node was investigated on 22 dogs. Using a small unipolar electrode positioned at the proximity of the sinus node and applying a 2-4-fold electric amplification, an early, slow and low-amplitude wave could be recorded 20-40 ms before the P wave. This early wave gradually decreased when the electrode was moved away from the sinus node and finally fused into the local P wave. Read More

Acta Physiol Acad Sci Hung 1982 ;59(3):287-90

Ni-induced coronary vasoconstriction has been studied in the dog heart in situ in the presence of the selective Ca-antagonist verapamil, and after blocking the alpha-receptors with phenoxybenzamine (PBZ). Verapamil totally abolished the coronary blood flow (CBF) and basal conductance (BC) decreasing effect of low doses of Ni2+ (0.02-0. Read More

Acta Physiol Acad Sci Hung 1982 ;59(3):283-6

The dimethylglyoxim cytochemical method was used for detecting endogenous nickel (Ni) in the canine and human myocardium. Electrondense deposits were observed in the myocardial cells and the wall and lumen of capillaries of the dog heart when after CO-intoxication the blood COHb level exceeded 30%. Energy-dispersive microanalysis proved the presence of Ni in the reaction product. Read More