6,703 results match your criteria Acta Physiologica[Journal]


Rodent models to study sodium retention in experimental nephrotic syndrome.

Acta Physiol (Oxf) 2022 May 15:e13844. Epub 2022 May 15.

Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, University Hospital Tübingen, Germany.

Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different experimental rodent models have been established for simulating NS, however, not all of them feature sodium retention which requires proteinuria to exceed a certain threshold. In rats, puromycin aminonucleoside nephrosis (PAN) is a classic NS model introduced in 1955 that was adopted as doxorubicin-induced nephropathy (DIN) in 129S1/SvImJ mice. Read More

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Extreme duration endurance exercise affects old and younger men differently-Older individuals experience a negative adaptive response affecting cardiovascular function.

Authors:
Jan Henriksson

Acta Physiol (Oxf) 2022 May 12:e13843. Epub 2022 May 12.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates.

Authors:
Angela Fago

Acta Physiol (Oxf) 2022 May 12:e13841. Epub 2022 May 12.

Department of Biology, Aarhus University, Aarhus, Denmark.

Hypoxic environments pose a severe challenge to vertebrates and even short periods of oxygen deprivation are often lethal as they constrain aerobic ATP production. However, a few ectotherm vertebrates are capable of surviving long-term hypoxia or even anoxia with little or no damage. Among these, freshwater turtles and crucian carp are the recognized champions of anoxia tolerance, capable of overwintering in complete oxygen deprivation for months at freezing temperatures by entering a stable hypometabolic state. Read More

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Perception.

Acta Physiol (Oxf) 2022 May 11:e13842. Epub 2022 May 11.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP receptor upregulation in mouse and human kidney.

Acta Physiol (Oxf) 2022 May 11:e13828. Epub 2022 May 11.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Aim: Cyclooxygenase-2 (COX-2) activity protects against oxidative stress and apoptosis early in experimental kidney injury. The present study was designed to test the hypothesis that COX-2 activity attenuates fibrosis and preserves microvasculature in injured kidney. The murine unilateral ureteral-obstruction (UUO) model of kidney fibrosis was employed and compared with human nephrectomy tissue with and without chronic hydronephrosis. Read More

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Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis.

Acta Physiol (Oxf) 2022 May 2:e13827. Epub 2022 May 2.

Division of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, California, USA.

Aim: Low-grade inflammation is the hallmark of non-alcoholic fatty liver diseases (NAFLD) and non-alcoholic steatohepatitis (NASH). The leakage of microbiota-derived products can contribute to liver inflammation during NAFLD/NASH development. Here, we assessed the roles of gut microbial DNA-containing extracellular vesicles (mEVs) in regulating liver cellular abnormalities in the course of NAFLD/NASH. Read More

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EPO synthesis induced by HIF-PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non-injured nephron segments in murine kidney fibrosis.

Acta Physiol (Oxf) 2022 May 1:e13826. Epub 2022 May 1.

Department of Medicine, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Aim: Erythropoietin (EPO) is regulated by hypoxia-inducible factor (HIF)-2. In the kidney, it is produced by cortico-medullary perivascular interstitial cells, which transdifferentiate into collagen-producing myofibroblasts in response to injury. Inhibitors of prolyl hydroxylase domain (PHD) dioxygenases (HIF-PHIs) activate HIF-2 and stimulate kidney and liver EPO synthesis in patients with anemia of chronic kidney disease (CKD). Read More

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Sorting out the rapid renal response to an oral phosphate load.

Authors:
Henrik Dimke

Acta Physiol (Oxf) 2022 Jun 3;235(2):e13824. Epub 2022 May 3.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

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Europhysiology 2022: Let's meet for real.

Acta Physiol (Oxf) 2022 Jun 3;235(2):e13825. Epub 2022 May 3.

University of Oslo, Oslo, Norway.

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Sex matters in neuromuscular control.

Acta Physiol (Oxf) 2022 Jun 23;235(2):e13823. Epub 2022 Apr 23.

Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, USA.

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Recent advances in kidney research.

Authors:
Ralf Mrowka

Acta Physiol (Oxf) 2022 Jun 22;235(2):e13820. Epub 2022 Apr 22.

Experimentelle Nephrologie, Universitätsklinikum Jena, Jena, Germany.

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Mass cytometry imaging in physiology.

Authors:
David Sedmera

Acta Physiol (Oxf) 2022 Jun 14;235(2):e13822. Epub 2022 Apr 14.

Laboratory of Developmental Cardiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

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Muscle-tendon architecture in Kenyans and Japanese: Potential role of genetic endowment in the success of elite Kenyan endurance runners.

Acta Physiol (Oxf) 2022 Jun 17;235(2):e13821. Epub 2022 Apr 17.

Graduate School of Sport and Exercise Sciences, Osaka University of Health and Sport Sciences, Osaka, Japan.

Aim: The specificity of muscle-tendon and foot architecture of elite Kenyan middle- and long-distance runners has been found to contribute to their superior running performance. To investigate the respective influence of genetic endowment and training on these characteristics, we compared leg and foot segmental lengths as well as muscle-tendon architecture of Kenyans and Japanese males (i) from infancy to adulthood and (ii) non-athletes versus elite runners.

Methods: The 676 participants were divided according to their nationality (Kenyans and Japanese), age (nine different age groups for non-athletes) and performance level in middle- and long-distance races (non-athlete, non-elite and elite adult runners). Read More

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Endothelial cells promote smooth muscle cell resilience to H O -induced cell death in mouse cerebral arteries.

Acta Physiol (Oxf) 2022 Jun 12;235(2):e13819. Epub 2022 Apr 12.

Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.

Aim: Brain injury produces reactive oxygen species (ROS). However, little is known of how acute oxidative stress affects cell survival in the cerebral vascular supply. We hypothesized that endothelial cells (ECs) are more resilient to H O and protect vascular smooth muscle cells (SMCs) during acute oxidative stress. Read More

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The accumulation rate of ribosomes predicts muscle training-induced hypertrophy.

Authors:
Jan Henriksson

Acta Physiol (Oxf) 2022 May 6;235(1):e13817. Epub 2022 Apr 6.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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Extreme duration exercise affects old and younger men differently.

Acta Physiol (Oxf) 2022 Mar 29:e13816. Epub 2022 Mar 29.

Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aim & Methods: Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30 ± 5 years or age 65 ± 6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days.

Results: Over the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. Read More

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Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals.

Acta Physiol (Oxf) 2022 Jun 6;235(2):e13815. Epub 2022 Apr 6.

Institute of Physiology, University of Zürich, Zürich, Switzerland.

Aims: Dietary inorganic phosphate (Pi) modulates renal Pi reabsorption by regulating the expression of the NaPi-IIa and NaPi-IIc Pi transporters. Here, we aimed to clarify the role of several Pi-regulatory mechanisms including parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23) and inositol hexakisphosphate kinases (IP6-kinases) in the acute regulation of NaPi-IIa and NaPi-IIc.

Methods: Wildtype (WT) and PTH-deficient mice (PTH-KO) with/without inhibition of FGF23 signalling were gavaged with Pi/saline and examined at 1, 4 and 12 h. Read More

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Illuminating physiology.

Acta Physiol (Oxf) 2022 May 30;235(1):e13814. Epub 2022 Mar 30.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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Muscle contraction and mitochondrial biogenesis - A brief historical reappraisal.

Acta Physiol (Oxf) 2022 May 30;235(1):e13813. Epub 2022 Mar 30.

Institute for Health and Sport (iHeS), Victoria University, Melbourne, Victoria, Australia.

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Corrigendum.

Authors:

Acta Physiol (Oxf) 2022 May 16;235(1):e13805. Epub 2022 Mar 16.

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Old pathways - New crossroads: Class 3 PI3K acts on glucocorticoid signal transduction.

Authors:
David Jacobi

Acta Physiol (Oxf) 2022 May 17;235(1):e13812. Epub 2022 Mar 17.

Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, Nantes, France.

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ENaC activation by proteases.

Acta Physiol (Oxf) 2022 May 21;235(1):e13811. Epub 2022 Mar 21.

Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.

Proteases are fundamental for a plethora of biological processes, including signalling and tissue remodelling, and dysregulated proteolytic activity can result in pathogenesis. In this review, we focus on a subclass of membrane-bound and soluble proteases that are defined as channel-activating proteases (CAPs), since they induce Na ion transport through an autocrine mechanism when co-expressed with the highly amiloride-sensitive epithelial sodium channel (ENaC) in Xenopus oocytes. These experiments first identified CAP1 (channel-activating protease 1, prostasin) followed by CAP2 (channel-activating protease 2, TMPRSS4) and CAP3 (channel-activating protease 3, matriptase) as in vitro mediators of ENaC current. Read More

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Open access to Ukrainian thoughts, not to their soil.

Authors:
Pontus B Persson

Acta Physiol (Oxf) 2022 04 7;234(4):e13810. Epub 2022 Mar 7.

Charité, Institute of Vegetative Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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Acta Physiologica, member of the top 5% club.

Authors:
Pontus B Persson

Acta Physiol (Oxf) 2022 May 2;235(1):e13807. Epub 2022 Mar 2.

Institute of Vegetative Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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Hepatic glucose production and storage as a potential strategy for type 2 diabetes treatment - The effect of catestatin - "just another new kid in town?"

Acta Physiol (Oxf) 2022 May 4;235(1):e13808. Epub 2022 Mar 4.

Institute of Biomedicine, Medical Research Center Oulu, Oulu University, and Oulu University Hospital, Finland.

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Mutational scanning of the CLOCKΔ19 domain identifies amino acids modulating circadian clock dynamics and co-regulator binding.

Authors:
Urs Albrecht

Acta Physiol (Oxf) 2022 04 3;234(4):e13809. Epub 2022 Mar 3.

Department of Biology, Biochemistry, University of Fribourg, Fribourg, Switzerland.

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Ribosome accumulation during early phase resistance training in humans.

Acta Physiol (Oxf) 2022 May 7;235(1):e13806. Epub 2022 Mar 7.

Section for Health and Exercise Physiology, Department of Public Health and Sport Sciences, Inland Norway University of Applied Sciences, Lillehammer, Norway.

Aim: To describe ribosome biogenesis during resistance training, its relation to training volume and muscle growth.

Methods: A training group (n = 11) performed 12 sessions (3-4 sessions per week) of unilateral knee extension with constant and variable volume (6 and 3-9 sets per session respectively) allocated to either leg. Ribosome abundance and biogenesis markers were assessed from vastus lateralis biopsies obtained at baseline, 48 hours after sessions 1, 4, 5, 8, 9 and 12, and after eight days of de-training, and from a control group (n = 8). Read More

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Sestrin/FNDC5: An ancient axis connecting exercise and thermoregulation.

Acta Physiol (Oxf) 2022 04 23;234(4):e13804. Epub 2022 Feb 23.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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Neuromuscular recruitment strategies of the vastus lateralis according to sex.

Acta Physiol (Oxf) 2022 Jun 2;235(2):e13803. Epub 2022 Mar 2.

Centre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research, (NIHR) Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Derby, UK.

Aim: Despite males typically exhibiting greater muscle strength and fatigability than females, it remains unclear if there are sex-based differences in neuromuscular recruitment strategies e.g. recruitment and modulation of motor unit firing rate (MU FR) at normalized forces and during progressive increases in force. Read More

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HDAC3 inhibition improves urinary-concentrating defect in hypokalaemia by promoting AQP2 transcription.

Acta Physiol (Oxf) 2022 04 25;234(4):e13802. Epub 2022 Feb 25.

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Aim: This study investigated whether enhanced histone acetylation, achieved by inhibiting histone deacetylases (HDACs), could prevent decreased aquaporin-2 (AQP2) expression during hypokalaemia.

Methods: Male Wistar rats were fed a potassium-free diet with or without 4-phenylbutyric acid (4-PBA) or the selective HDAC3 inhibitor RGFP966 for 4 days. Primary renal inner medullary collecting duct (IMCD) cells and immortalized mouse cortical collecting duct (mpkCCD) cells were cultured in potassium-deprivation medium with or without HDAC inhibitors. Read More

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