6,416 results match your criteria Acta Physiologica[Journal]


Improvement of physical training by performance enhancing substances.

Authors:
Cem Erdogan

Acta Physiol (Oxf) 2020 Jun 3:e13517. Epub 2020 Jun 3.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Vegetative Physiology, Germany.

Currently the Covid-19 pandemic forces almost every country to take drastic measures in order to stop the spread of the virus. These include the avoidance of close contact to other humans, staying at home whenever possible and the closure of gyms or sport clubs. Now that people are more or less bound to their home, it is even more important to stay physically active. Read More

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http://dx.doi.org/10.1111/apha.13517DOI Listing

Intermittent fasting - the new lifestyle?

Acta Physiol (Oxf) 2020 Jun 2:e13518. Epub 2020 Jun 2.

Charité, - Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin, Humboldt Universität zu Berlin and the Berlin Institute of Health, Institute of Vegetative Physiology, Berlin, Germany.

Obesity has become a pandemic that affects all populations of all ages living in countries of all income levels. Attributed to sedentary lifestyle and energy dense diet, obesity is a risk factor for cardiovascular disease, insulin resistance, type 2 diabetes, and even some types of cancer. These comorbidities also affect the immune system adversely and can exacerbate infectious diseases as observed in the most recent case of pandemic COVID-19. Read More

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http://dx.doi.org/10.1111/apha.13518DOI Listing

Found formula for outperforming manuscripts.

Acta Physiol (Oxf) 2020 Jun 2:e13515. Epub 2020 Jun 2.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Vegetative Physiology, Berlin, Germany.

Finally, I (PBP) discovered the right book for me. After starting a few other ones, putting them down, forcing myself to read on, taking another break, I abandoned the book pile with a bad conscious. After weeks of search, this is my page-turner, keeping me up at night. Read More

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http://dx.doi.org/10.1111/apha.13515DOI Listing

Activated FMS-like tyrosine kinase 3 ameliorates Angiotensin II-induced cardiac remodeling.

Acta Physiol (Oxf) 2020 Jun 1. Epub 2020 Jun 1.

Department of Pharmacology, School of Basic Medicine Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.

Aim: FMS-like receptor tyrosine kinase 3 (Flt3) has been reported to be increased in cardiomyocytes responding to ischemic stress. This study was to determine whether Flt3 activation could ameliorate pressure overload-induced heart hypertrophy and fibrosis, and to elucidate the mechanisms of action.

Methods: In vivo cardiac hypertrophy and remodeling experiments were conducted by infusing angiotensin II (Ang II) chronically in male C57BL/6 mice. Read More

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http://dx.doi.org/10.1111/apha.13519DOI Listing

Pathophysiological mechanisms explaining poor clinical outcome of older cancer patients with low skeletal muscle mass.

Acta Physiol (Oxf) 2020 Jun 1:e13516. Epub 2020 Jun 1.

Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.

Low skeletal muscle mass is highly prevalent in older cancer patients and affects 5% to 89% depending on the type and stage of cancer. Low skeletal muscle mass is associated with poor clinical outcomes such as postoperative complications, chemotherapy toxicity and mortality in older cancer patients. Little is known about the mediating pathophysiological mechanisms. Read More

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http://dx.doi.org/10.1111/apha.13516DOI Listing

Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism.

Acta Physiol (Oxf) 2020 Jun 1:e13514. Epub 2020 Jun 1.

Institute of Experimental Physiology (IFISE), National Scientific and Technical Research Council (CONICET), National University of Rosario (UNR), Suipacha 570, S2002LRL, Rosario, Argentina.

Aim: MRP2 is an intestinal ABC transporter that prevents the absorption of dietary xenobiotics. The aims of this work were: i) to evaluate whether a short-term regulation of intestinal MRP2 barrier function takes place in vivo after luminal incorporation of nutrients and ii) to explore the underlying mechanism.

Methods: MRP2 activity and localization were assessed in an in vivo rat model with preserved irrigation and innervation. Read More

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http://dx.doi.org/10.1111/apha.13514DOI Listing

An update on ACE2 amplification and its therapeutic potential.

Acta Physiol (Oxf) 2020 May 29:e13513. Epub 2020 May 29.

Northwestern University, Feinberg Medical School, Chicago, IL, United States.

The renin angiotensin system (RAS) plays an important role in the pathogenesis of variety of diseases. Targeting the formation and action of angiotensin II (Ang II), the main RAS peptide, has been the key therapeutic target for last three decades. ACE-related carboxypeptidase (ACE2), a monocarboxypeptidase that had been discovered 20 years ago, is one of the catalytically most potent enzymes known to degrade Ang II to Ang-(1-7), a peptide that is increasingly accepted to have organ -protective properties that oppose and counterbalance those of Ang II. Read More

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http://dx.doi.org/10.1111/apha.13513DOI Listing

Plasminogen deficiency does not prevent sodium retention in a genetic mouse model of experimental nephrotic syndrome.

Acta Physiol (Oxf) 2020 May 26. Epub 2020 May 26.

Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, University Hospital Tübingen, Germany.

Aim: Sodium retention is the hallmark of nephrotic syndrome (NS) and mediated by the proteolytic activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases. Plasmin is highly abundant in nephrotic urine and has been proposed to be the principal serine protease responsible for ENaC activation in NS. However, a proof of the essential role of plasmin in experimental NS is lacking. Read More

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http://dx.doi.org/10.1111/apha.13512DOI Listing

Did you know? Fluid-and-electrolyte replacement and the uncertainty principle.

Authors:
Friedrich C Luft

Acta Physiol (Oxf) 2020 May 23. Epub 2020 May 23.

Experimental and Clinical Research Center, Max-Delbrück Center and Charité Medical Faculty, Berlin, Germany.

Surprises are not always welcome. We have studied total body water, quantified the volume and determined the extracellular space, interstitial, and plasma volumes. Nonetheless, estimating these parameters clinically (at the bedside) is frustratingly imprecise. Read More

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http://dx.doi.org/10.1111/apha.13511DOI Listing

Targeting desmosomal adhesion and signalling for intestinal barrier stabilization in inflammatory bowel diseases-Lessons from experimental models and patients.

Acta Physiol (Oxf) 2020 May 18:e13492. Epub 2020 May 18.

Department I, Institute of Anatomy and Cell Biology, Faculty of Medicine, Ludwig Maximilians University Munich, Munich, Germany.

Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and Ulcerative colitis (UC) have a complex and multifactorial pathogenesis which is incompletely understood. A typical feature closely associated with clinical symptoms is impaired intestinal epithelial barrier function. Mounting evidence suggests that desmosomes, which together with tight junctions (TJ) and adherens junctions (AJ) form the intestinal epithelial barrier, play a distinct role in IBD pathogenesis. Read More

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http://dx.doi.org/10.1111/apha.13492DOI Listing

Massage during muscle unloading increases protein turnover in the massaged and non-massaged, contralateral limb, but does not attenuate muscle atrophy.

Acta Physiol (Oxf) 2020 May 15:e13497. Epub 2020 May 15.

Max E. Wastl Human Performance Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA.

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http://dx.doi.org/10.1111/apha.13497DOI Listing

Slc26a3 deletion alters pH-microclimate, mucin biosynthesis, microbiome composition and increases Tnfα expression in murine colon.

Acta Physiol (Oxf) 2020 May 15:e13498. Epub 2020 May 15.

Department of Gastroenterology, Hannover Medical School, Hannover, Germany.

Aim: SLC26A3 (DRA) mediates the absorption of luminal Cl in exchange for HCO in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) and strongly decreased in the presence of intestinal inflammation. To characterize the consequences of a loss of Slc26a3 beyond disturbed electrolyte transport, colonic mucus synthesis, surface accumulation and composition, pH microclimate, microbiome composition and development of inflammation was studied in slc26a3 mice. Read More

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http://dx.doi.org/10.1111/apha.13498DOI Listing

Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signalling.

Acta Physiol (Oxf) 2020 May 14:e13496. Epub 2020 May 14.

Venetian Institute of Molecular Medicine (VIMM), Padova, Italy.

Aim: Resistance exercise increases muscle mass over time. However, the early signalling events leading to muscle growth are not yet well-defined. Here, we aim to identify new signalling pathways important for muscle remodelling after exercise. Read More

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http://dx.doi.org/10.1111/apha.13496DOI Listing

Response to Swenson and Bärtsch.

Acta Physiol (Oxf) 2020 May 9:e13494. Epub 2020 May 9.

Dept. of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1111/apha.13494DOI Listing

The sodium channel Na 1.5 impacts on early murine embryonic cardiac development, structure and function in a non-electrogenic manner.

Acta Physiol (Oxf) 2020 May 9:e13493. Epub 2020 May 9.

Department of Experimental Cardiology, Amsterdam UMC (location Academic Medical Center), Amsterdam, the Netherlands.

Aim: The voltage-gated sodium channel Na 1.5, encoded by SCN5A, is essential for cardiac excitability and ensures proper electrical conduction. Early embryonic death has been observed in several murine models carrying homozygous Scn5amutations. Read More

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http://dx.doi.org/10.1111/apha.13493DOI Listing

Cystic Fibrosis Transmembrane Conductance Regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation.

Acta Physiol (Oxf) 2020 May 9. Epub 2020 May 9.

School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.

Aim: Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in the heart, but its function there is unclear. CFTR regulates an ATP release pore in many tissues, but the identity and regulatory mechanism of the pore are unknown. We investigated the role of CFTR in ATP release from primary cardiomyocytes and ventricular wall in vivo. Read More

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http://dx.doi.org/10.1111/apha.13495DOI Listing

A breath of fresh air for mitochondria in exercise physiology.

Authors:
Martin Burtscher

Acta Physiol (Oxf) 2020 May 4:e13490. Epub 2020 May 4.

Martin Burtscher, University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1111/apha.13490DOI Listing

Co-cultures of renal progenitors and endothelial cells on kidney decellularized matrices replicate the renal tubular environment in vitro.

Acta Physiol (Oxf) 2020 May 4:e13491. Epub 2020 May 4.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Portugal.

Aim: Herein we propose creating a bilayer tubular kidney in-vitro model. It is hypothesized that membranes composed of decellularized porcine kidney extracellular matrix are valid substitutes of the tubular basement membrane by mimicking the physiological relevance of the in vivo environment and disease phenotypes.

Methods: Extracellular matrix was obtained from decellularized porcine kidneys. Read More

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http://dx.doi.org/10.1111/apha.13491DOI Listing

Contribution of oxygen extraction fraction to maximal oxygen uptake in healthy young men.

Acta Physiol (Oxf) 2020 May 4:e13486. Epub 2020 May 4.

Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.

We analysed the importance of systemic and peripheral arteriovenous O difference ( difference and a-v O difference, respectively) and O extraction fraction for maximal oxygen uptake ( ). Fick law of diffusion and the Piiper and Scheid model were applied to investigate whether diffusion versus perfusion limitations vary with . Articles (n = 17) publishing individual data (n = 154) on , maximal cardiac output ( ; indicator-dilution or the Fick method), difference (catheters or the Fick equation) and systemic O extraction fraction were identified. Read More

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http://dx.doi.org/10.1111/apha.13486DOI Listing

Immunity and Hypertension.

Acta Physiol (Oxf) 2020 May 2. Epub 2020 May 2.

Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.

Hypertension is the primary cause of cardiovascular mortality. Despite multiple existing treatments, only half of those with the disease achieve adequate control. Therefore, understanding the mechanisms causing hypertension is essential for the development of novel therapies. Read More

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http://dx.doi.org/10.1111/apha.13487DOI Listing

The enzyme L-arginase type 2 in proximal tubular epithelium links urea accumulation and protection against ischemic insults in kidney.

Authors:
Boye L Jensen

Acta Physiol (Oxf) 2020 May 2:e13489. Epub 2020 May 2.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1111/apha.13489DOI Listing

Passive exposure to heat improves glucose metabolism in overweight humans.

Acta Physiol (Oxf) 2020 May 2:e13488. Epub 2020 May 2.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.

Aim: Heat exposure has been indicated to positively affect glucose metabolism. An involvement of heat shock protein 72 (HSP72) in the enhancement of insulin sensitivity upon heat exposure has been previously suggested. Here, we performed an intervention study exploring the effect of passive heat acclimation (PHA) on glucose metabolism and intracellular (a) HSP72 concentrations in overweight humans. Read More

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http://dx.doi.org/10.1111/apha.13488DOI Listing

The search for a model of high-altitude pulmonary oedema must continue.

Acta Physiol (Oxf) 2020 Apr 28:e13485. Epub 2020 Apr 28.

Sports Medicine, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/apha.13485DOI Listing

Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion.

Acta Physiol (Oxf) 2020 Apr 27:e13483. Epub 2020 Apr 27.

Department of Medicine, Queen's University, Kingston, ON, Canada.

Aim: Pulmonary arterial hypertension (PAH) results in right ventricular (RV) dysfunction owing, in part, to RV ischemia. The relative contribution of RV microvascular rarefaction vs reduced right coronary artery perfusion pressure (RCA-PP) to RV ischemia remains unknown. We hypothesize that increasing RCA-PP improves RV function in PAH by increasing RV systolic perfusion. Read More

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http://dx.doi.org/10.1111/apha.13483DOI Listing

Nitrergic perivascular innervation in health and diseases: Focus on vascular tone regulation.

Authors:
Fabiano E Xavier

Acta Physiol (Oxf) 2020 Apr 26:e13484. Epub 2020 Apr 26.

Departamento de Fisiologia e Farmacologia, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Brazil.

For a long time, the vascular tone was considered to be regulated exclusively by tonic innervation of vasoconstrictor adrenergic nerves. However, accumulating experimental evidence has revealed the existence of nerves mediating vasodilatation, including perivascular nitrergic nerves (PNN), in a wide variety of mammalian species. Functioning of nitrergic vasodilator nerves is evidenced in several territories, including cerebral, mesenteric, pulmonary, renal, penile, uterine and cutaneous arteries. Read More

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http://dx.doi.org/10.1111/apha.13484DOI Listing

Integrins-Mediators of cellular adhesion or more?

Authors:
Juergen Eckel

Acta Physiol (Oxf) 2020 Apr 24:e13482. Epub 2020 Apr 24.

Institute for Clinical Diabetology, German Diabetes Center, Düsseldorf, Germany.

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http://dx.doi.org/10.1111/apha.13482DOI Listing

Mechanism-based QT/APD-shortening therapy for potassium-channel-based long-QT syndromes?

Authors:
Katja E Odening

Acta Physiol (Oxf) 2020 Apr 24:e13481. Epub 2020 Apr 24.

Translational Cardiology, Department of Cardiology, Inselspital, Bern University Hospital, and Institute of Physiology, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1111/apha.13481DOI Listing

Polyamines, metabolites and metabolomics.

Acta Physiol (Oxf) 2020 Apr 24:e13480. Epub 2020 Apr 24.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Vegetative Physiology, Berlin, Germany.

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http://dx.doi.org/10.1111/apha.13480DOI Listing

Biomarkers and predicting acute kidney injury.

Authors:
Friedrich C Luft

Acta Physiol (Oxf) 2020 Apr 20:e13479. Epub 2020 Apr 20.

Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine.

Aim: How can we convert biomarkers into reliable, validated laboratory tests? Glomerular filtration rate (GFR) estimators exist for more than a century. The first utilitarian biomarkers were endogenously produced urea and creatinine. Clinicians then developed simple tests to determine whether or not renal tubular function was maintained. Read More

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http://dx.doi.org/10.1111/apha.13479DOI Listing

Exercise and cardiovascular diseases.

Acta Physiol (Oxf) 2020 Jun 8;229(2):e13476. Epub 2020 May 8.

Department for Angiology, Center for Internal Medicine I, Clinic Brandenburg, Brandenburg Medical School (MHB) & Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus - Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam, Brandenburg an der Havel, Germany.

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http://dx.doi.org/10.1111/apha.13476DOI Listing

Reactive oxygen species in renal vascular function.

Acta Physiol (Oxf) 2020 Apr 20:e13477. Epub 2020 Apr 20.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Vegetative Physiology, Berlin, Germany.

Reactive oxygen species (ROS) are produced by the aerobic metabolism. The imbalance between production of ROS and antioxidant defence in any cell compartment is associated with cell damage and may play an important role in the pathogenesis of renal disease. NADPH oxidase (NOX) family is the major ROS source in the vasculature and modulates renal perfusion. Read More

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http://dx.doi.org/10.1111/apha.13477DOI Listing

Serotonin homeostasis in the materno-foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta.

Acta Physiol (Oxf) 2020 Apr 20:e13478. Epub 2020 Apr 20.

Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Charles University, Hradec Kralove, Czech Republic.

Aim: Serotonin is crucial for proper foetal development, and the placenta has been described as a 'donor' of serotonin for the embryo/foetus. However, in later stages of gestation the foetus produces its own serotonin from maternally-derived tryptophan and placental supply is no longer needed. We propose a novel model of serotonin homeostasis in the term placenta with special focus on the protective role of organic cation transporter 3 (OCT3/SLC22A3). Read More

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http://dx.doi.org/10.1111/apha.13478DOI Listing

Prolonged therapeutic effects of photoactivated adipose-derived stem cells following ischaemic injury.

Acta Physiol (Oxf) 2020 Apr 19:e13475. Epub 2020 Apr 19.

Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Drug Discovery Research Center, Southwest Medical University, Luzhou, China.

Aim: Adipose-derived stem cells (ASCs) therapies are emerging as a promising approach to therapeutic angiogenesis. Therapeutic persistence and reduced primitive stem cell function following cell delivery remains a critical hurdle for the clinical translation of stem cells in current approaches.

Methods: Cultured ASCs were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet (ND). Read More

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http://dx.doi.org/10.1111/apha.13475DOI Listing

Growing knowledge: How growth hormone improves learning.

Acta Physiol (Oxf) 2020 Jun 17;229(2):e13474. Epub 2020 Apr 17.

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1111/apha.13474DOI Listing

Finally, a promising model for high-altitude pulmonary edema (HAPE)-A Mountaineers' Malady.

Authors:
Mikko Nikinmaa

Acta Physiol (Oxf) 2020 Jun 16;229(2):e13472. Epub 2020 Apr 16.

Department of Biology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1111/apha.13472DOI Listing

Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19.

Acta Physiol (Oxf) 2020 Mar 29:e13473. Epub 2020 Mar 29.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/apha.13473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228251PMC

Polyunsaturated fatty acid-derived I channel activators shorten the QT interval ex-vivo and in-vivo.

Acta Physiol (Oxf) 2020 Mar 29:e13471. Epub 2020 Mar 29.

The Danish Arrhythmia Research Centre and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aim: We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts.

Methods: The effect of one natural (docosahexaenoic acid [DHA]) and three modified (linoleoyl glycine [Lin-GLY], docosahexaenoyl glycine [DHA-GLY], N-arachidonoyl taurine [N-AT]) PUFAs on ventricular action potential duration (APD) and QT interval was studied in a E4031 drug-induced long QT2 model of ex-vivo guinea pig hearts. The effect of DHA-GLY on QT interval was also studied in in-vivo guinea pig hearts upon intravenous administration. Read More

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http://dx.doi.org/10.1111/apha.13471DOI Listing

SARS-CoV-2: What do we know so far?

Acta Physiol (Oxf) 2020 06 11;229(2):e13470. Epub 2020 Apr 11.

Institut für Vegetative Physiologie, Charité - Universitätsmedizin Berlin, corporate member of the Freie Universität Berlin, Humboldt Universität zu Berlin and the Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1111/apha.13470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228362PMC

Did you know? Why is essential hypertension essential-Or is it?

Authors:
Friedrich C Luft

Acta Physiol (Oxf) 2020 Mar 21:e13469. Epub 2020 Mar 21.

Experimental and Clinical Research Center, Charité Medical Faculty, Berlin, Germany.

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http://dx.doi.org/10.1111/apha.13469DOI Listing

The concept of skeletal muscle memory: Evidence from animal and human studies.

Acta Physiol (Oxf) 2020 Mar 16:e13465. Epub 2020 Mar 16.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.

Within the current paradigm of the myonuclear domain theory, it is postulated that a linear relationship exists between muscle fibre size and myonuclear content. The myonuclear domain is kept (relatively) constant by adding additional nuclei (supplied by muscle satellite cells) during muscle fibre hypertrophy and nuclear loss (by apoptosis) during muscle fibre atrophy. However, data from recent animal studies suggest that myonuclei that are added to support muscle fibre hypertrophy are not lost within various muscle atrophy models. Read More

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http://dx.doi.org/10.1111/apha.13465DOI Listing

Harnessing the protective role of OPA1 in diabetic cardiomyopathy.

Acta Physiol (Oxf) 2020 May 29;229(1):e13466. Epub 2020 Mar 29.

Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.

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http://dx.doi.org/10.1111/apha.13466DOI Listing

Endogenous brain-sparing responses in brain pH and PO in a rodent model of birth asphyxia.

Acta Physiol (Oxf) 2020 Mar 16:e13467. Epub 2020 Mar 16.

Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki, Finland.

Aim: To study brain-sparing physiological responses in a rodent model of birth asphyxia which reproduces the asphyxia-defining systemic hypoxia and hypercapnia.

Methods: Steady or intermittent asphyxia was induced for 15-45 minutes in anaesthetized 6- and 11-days old rats and neonatal guinea pigs using gases containing 5% or 9% O plus 20% CO (in N ). Hypoxia and hypercapnia were induced with low O and high CO respectively. Read More

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http://dx.doi.org/10.1111/apha.13467DOI Listing

Intracellular events in diabetes mellitus - Behind the scenes.

Authors:
Isabel Auge

Acta Physiol (Oxf) 2020 May 25;229(1):e13468. Epub 2020 Mar 25.

Klinik für Innere Medizin III, AG Experimentelle Nephrologie, Universitätsklinikum Jena, Jena, Germany.

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http://dx.doi.org/10.1111/apha.13468DOI Listing

In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion.

Acta Physiol (Oxf) 2020 Mar 7:e13464. Epub 2020 Mar 7.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aim: It is debated whether the inhibition of glucagon secretion by glucose results from direct effects of glucose on the α-cell (intrinsic regulation) or by paracrine effects exerted by beta- or delta-cell products.

Methods: To study this in a more physiological model than isolated islets, we perfused isolated rat pancreases and measured glucagon, insulin and somatostatin secretion in response to graded increases in perfusate glucose concentration (from 3.5 to 4, 5, 6, 7, 8, 10, 12 mmol/L) as well as glucagon responses to blockage/activation of insulin/GABA/somatostatin signalling with or without addition of glucose. Read More

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http://dx.doi.org/10.1111/apha.13464DOI Listing
March 2020
4.382 Impact Factor

Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake.

Acta Physiol (Oxf) 2020 Mar 6:e13463. Epub 2020 Mar 6.

Swedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.

Aims: The body responds to exercise training by profound adaptations throughout the cardiorespiratory and muscular systems, which may result in improvements in maximal oxygen consumption (VO peak) and mitochondrial capacity. By convenience, mitochondrial respiration is often measured at supra-physiological oxygen levels, an approach that ignores any potential regulatory role of mitochondrial affinity for oxygen (p50 ) at physiological oxygen levels.

Methods: In this study, we examined the p50 of mitochondria isolated from the Vastus lateralis and Triceps brachii in 12 healthy volunteers before and after a training intervention with seven sessions of sprint interval training using both leg cycling and arm cranking. Read More

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http://dx.doi.org/10.1111/apha.13463DOI Listing

Mirror, mirror on the wall, which physiology journal is the fairest of all?

Authors:
Pontus B Persson

Acta Physiol (Oxf) 2020 Mar 6:e13462. Epub 2020 Mar 6.

Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Vegetative Physiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/apha.13462DOI Listing

Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE).

Acta Physiol (Oxf) 2020 Jun 16;229(2):e13461. Epub 2020 Mar 16.

Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.

Aim: High-altitude pulmonary oedema (HAPE) is a non-cardiogenic pulmonary oedema that can occur during rapid ascent to a high-altitude environment. Classically, HAPE has been described as a condition resulting from a combination of pulmonary vasoconstriction and hypertension. Inflammation has been described as important in HAPE, although as a side effect of pulmonary oedema rather than as a causative factor. Read More

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http://dx.doi.org/10.1111/apha.13461DOI Listing

Massage as a mechanotherapy promotes skeletal muscle protein and ribosomal turnover but does not mitigate muscle atrophy during disuse in adult rats.

Acta Physiol (Oxf) 2020 Mar 3:e13460. Epub 2020 Mar 3.

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Aim: Interventions that decrease atrophy during disuse are desperately needed to maintain muscle mass. We recently found that massage as a mechanotherapy can improve muscle regrowth following disuse atrophy. Therefore, we aimed to determine if massage has similar anabolic effects when applied during normal weight bearing conditions (WB) or during atrophy induced by hindlimb suspension (HS) in adult rats. Read More

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http://dx.doi.org/10.1111/apha.13460DOI Listing

Alterations in ubiquitin-mediated degradation of Na 1.5 can cause arrhythmia.

Acta Physiol (Oxf) 2020 Jun 9;229(2):e13459. Epub 2020 Mar 9.

Cardiovascular Genetics Group, Girona Biomedical Research Institute (IDIBGI), Girona, Spain.

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http://dx.doi.org/10.1111/apha.13459DOI Listing

Sleep disordered breathing in pregnancy: A review of the pathophysiology of adverse pregnancy outcomes.

Acta Physiol (Oxf) 2020 Jun 10;229(2):e13458. Epub 2020 Mar 10.

Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom.

Sleep disordered breathing (SDB) is a common obesity-related co-morbidity with strong associations to cardiometabolic disease. The risk of SDB is increased during pregnancy, particularly among obese pregnant women. Accumulating evidence suggests that an association exists between maternal SDB and the development of adverse pregnancy outcomes, particularly gestational diabetes and hypertensive disorders of pregnancy. Read More

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http://dx.doi.org/10.1111/apha.13458DOI Listing