6,226 results match your criteria Acta Physiologica[Journal]


Inflammation - dysregulated inflammatory response and strategies for treatment.

Authors:
K Herold R Mrowka

Acta Physiol (Oxf) 2019 Apr 22:e13284. Epub 2019 Apr 22.

Klinik für Innere Medizin III, AG Experimentelle, Nephrologie, Universitätsklinikum Jena, Jena, Germany.

Inflammation is a natural protective response to microbial infections and tissue injury. It functions to eliminate harmful stimuli and to repair damaged tissue. The inflammatory response is initiated by different inducers of exogenous and endogenous origin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13284DOI Listing

Fibre hypertrophy, satellite cell and myonuclear adaptations to resistance training: Have very old individuals reached the ceiling for muscle fibre plasticity?

Acta Physiol (Oxf) 2019 Apr 22:e13287. Epub 2019 Apr 22.

Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

In this issue of Acta Physiologica, Karlsen et al. report original data suggesting lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with 12 weeks of resistance training in very old (83-94-years) men and women. These findings further our understanding of muscle remodelling responses to exercise at the most advanced stages of ageing, and spur additional research on the optimization of training protocols to combat muscle loss. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13287DOI Listing

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Acta Physiol (Oxf) 2019 Apr 21:e13286. Epub 2019 Apr 21.

Department of Internal Medicine, Division of Endocrinology Division of Endocrinology Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany.

Aim: In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC). This concept predicts that uPA is an important factor for sodium retention and that inhibition of uPA might be protective in nephrotic syndrome.

Methods: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13286DOI Listing
April 2019
1 Read

Role of the immune system in vascular function and blood pressure control induced by fecal microbiota transplantation in rats.

Acta Physiol (Oxf) 2019 Apr 20:e13285. Epub 2019 Apr 20.

Department of Pharmacology, School of Pharmacy, University of Granada, Centro de Investigaciones Biomédicas, 18071, Granada, Spain.

Aim: High blood pressure (BP) is associated with gut microbiota dysbiosis. The aim of this study was to investigate whether changes in gut microbiota induced by exchanging the gut microbiota between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) alter the gut-immune system interaction inducing changes in vascular function and BP.

Methods: Twenty-week-old recipient WKY and SHR were orally gavaged with donor fecal contents from WKY or SHR. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13285
Publisher Site
http://dx.doi.org/10.1111/apha.13285DOI Listing
April 2019
1 Read

Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms.

Acta Physiol (Oxf) 2019 Apr 19:e13282. Epub 2019 Apr 19.

Institute of Physiology of the Czech Academy of Sciences, Prague.

Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13282
Publisher Site
http://dx.doi.org/10.1111/apha.13282DOI Listing
April 2019
2 Reads

GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.

Acta Physiol (Oxf) 2019 Apr 19:e13283. Epub 2019 Apr 19.

University of Navarra, Department of Nutrition, Food Science and Physiology, Pamplona, Spain.

Aim: The facilitative glucose transporter GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. GLUT12 is expressed in insulin sensitive tissues such as adipose tissue. The aim of this work was to investigate GLUT12 expression and hormonal regulation in 3T3-L1 adipocytes and in adipose tissue of lean and diet-induced obese mice. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13283
Publisher Site
http://dx.doi.org/10.1111/apha.13283DOI Listing
April 2019
1 Read

The importance of being rhythmic: living in harmony with your body clocks.

Authors:
Charna Dibner

Acta Physiol (Oxf) 2019 Apr 12:e13281. Epub 2019 Apr 12.

Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland.

Circadian rhythms have developed in all light sensitive organisms, including humans, as a fundamental anticipatory mechanism that enables proactive adaptation to environmental changes. The circadian system is organized in a highly hierarchical manner, with clocks operative in most cells of the body ensuring the temporal coordination of physiological processes. Circadian misalignment, stemming from modern life style, draws increasing attention due to its tight association with the development of metabolic, cardiovascular, inflammatory and mental diseases as well as cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13281DOI Listing

[Ca ] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries - relation to noradrenaline release and contraction.

Acta Physiol (Oxf) 2019 Apr 8:e13279. Epub 2019 Apr 8.

Department of Biomedicine, University of Aarhus, Denmark.

Aim: This study aimed to assess intracellular Ca dynamics in nerve cells and Schwann cells in isolated rat resistance arteries and determine how these dynamics modify noradrenaline release from the nerves and consequent force development.

Methods: Ca in nerves was assessed with confocal imaging, noradrenaline release with amperometry, and artery tone with wire myography. Ca in axons was assessed after loading with Oregon Green 488 BAPTA-1 dextran. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13279
Publisher Site
http://dx.doi.org/10.1111/apha.13279DOI Listing
April 2019
2 Reads

Anti-fibrotic mechanisms of angiotensin AT -receptor stimulation.

Acta Physiol (Oxf) 2019 Apr 8:e13280. Epub 2019 Apr 8.

IMM - Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark.

The angiotensin AT -receptor is a main receptor of the protective arm of the renin-angiotensin-system. Understanding of this unconventional G-protein coupled receptor has significantly advanced during the past decade, largely because of the availability of a selective non-peptide AT -receptor agonist, which allowed the conduct of a multitude of studies in animal disease models. This article reviews such preclinical studies that in their entirety provide strong evidence for an anti-fibrotic effect mediated by activation of the AT -receptor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13280DOI Listing

miR-29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy-related genes.

Acta Physiol (Oxf) 2019 Apr 3:e13278. Epub 2019 Apr 3.

Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

Aim: To Identify microRNAs (miRs) involved in the regulation of skeletal muscle mass. For that purpose, we have initially utilized an in silico analysis, resulting in the identification of miR-29c as a positive regulator of muscle mass.

Methods: miR-29c was electrotransferred to the tibialis anterior to address its morphometric and functional properties and to determine the level of satellite cell proliferation and differentiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13278DOI Listing

Acta Physiologica announces: publishing for nothing, open access for free for all German authors!

Authors:
P B Persson

Acta Physiol (Oxf) 2019 Apr 1:e13277. Epub 2019 Apr 1.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13277DOI Listing

Intermittent hypoxia: Friend and foe.

Acta Physiol (Oxf) 2019 Mar 20:e13276. Epub 2019 Mar 20.

Institut für Vegetative Physiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.

We are not sure whether Andrew Scott and Trevor Griffin reflected on the phenomenon of intermittent hypoxia, when they wrote this song text in the late seventies - presumably not. These lines may also not be taken too literally with regard to the health problems arising from inadequate enjoyment of the preferred elixir of life. Yet, they refer to a relevant physiological issue: the Janus-faced nature of oxygen and its harmful relative - hypoxia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13276DOI Listing

Cancer - An ongoing fight searching for reasons and therapies.

Acta Physiol (Oxf) 2019 May 30;226(1):e13275. Epub 2019 Mar 30.

Klinik für Innere Medizin III, AG Experimentelle Nephrologie, Universitätsklinikum Jena, Jena, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13275DOI Listing
May 2019
1 Read

Renoprotective effects of cardiotrophin-1 in a mouse model of chronic kidney disease.

Authors:
Kirsten Madsen

Acta Physiol (Oxf) 2019 Mar 14:e13274. Epub 2019 Mar 14.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13274DOI Listing

Endothelial muscarinic M -receptors: A Σ-target?

Authors:
Paul M Vanhoutte

Acta Physiol (Oxf) 2019 May 29;226(1):e13273. Epub 2019 Mar 29.

State Key Laboratory of Biopharmaceutical Technologies, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13273DOI Listing

Opposing effects of 25-hydroxy- and 1α,25-dihydroxy-vitamin D on pro-cachectic cytokine-and cancer conditioned medium-induced atrophy in C2C12 myotubes.

Acta Physiol (Oxf) 2019 Mar 4:e13269. Epub 2019 Mar 4.

Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Aim: Loss of skeletal muscle is one of the main features of cancer cachexia. Vitamin D (VD) deficiency is associated with impairment of muscle mass and performance and is highly prevalent in cachectic patients; therefore, VD supplementation has been proposed to counteract cancer cachexia-associated muscle loss. However, in both cachectic cancer patients and tumour-bearing animals, VD supplementation led to disappointing results, urging the need for a better understanding of VD activity on skeletal muscle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13269DOI Listing

Renal denervation attenuates pressure overload-induced cardiac remodelling in rats with biphasic regulation of autophagy.

Acta Physiol (Oxf) 2019 Mar 4:e13272. Epub 2019 Mar 4.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Aim: This study aimed to investigate effects of renal denervation (RDN) on pressure overload-induced cardiac remodelling in rats and the related mechanisms.

Methods: Adult male Sprague-Dawley rats underwent transverse aortic constriction (TAC) to generate cardiac remodelling. RDN was performed 1 week after TAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13272DOI Listing
March 2019
3 Reads

Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications.

Acta Physiol (Oxf) 2019 Mar 4:e13270. Epub 2019 Mar 4.

Laboratory of Neurobiology, Centro de Investigación Principe Felipe, Valencia, Spain.

Several million patients with liver cirrhosis suffer minimal hepatic encephalopathy (MHE), with mild cognitive and coordination impairments that reduce their quality of life and life span. Hyperammonaemia and peripheral inflammation act synergistically to induce these neurological alterations. We propose that MHE appearance is because of the changes in peripheral immune system, which are transmitted to brain, leading to neuroinflammation that alters neurotransmission leading to cognitive and motor alterations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13270DOI Listing
March 2019
2 Reads

Lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with resistance training in 83-94-year-old men and women.

Acta Physiol (Oxf) 2019 Mar 3:e13271. Epub 2019 Mar 3.

Institute of Sports Medicine Copenhagen, Department of Orthopaedic Surgery M, Bispebjerg Hospital, Copenhagen, Denmark.

Aims: To examine satellite cell and myonuclear content in very old (≥83 years) individuals, and the response to heavy resistance training.

Methods: A group of very old men and women (Old, 83-94 years, n = 29) was randomized to 12 weeks of heavy resistance training or untrained controls. A group of young men who did not resistance train (Young, 19-27 years, n = 9) were included for comparison. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13271
Publisher Site
http://dx.doi.org/10.1111/apha.13271DOI Listing
March 2019
13 Reads

Pharmacological inhibition of the F -ATPase/P2Y pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.

Acta Physiol (Oxf) 2019 Mar 1:e13268. Epub 2019 Mar 1.

INSERM, UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse, Paul Sabatier University, Toulouse, France.

Aim: The contribution of apolipoprotein A1 (APOA1), the major apolipoprotein of high-density lipoprotein (HDL), to endothelium-dependent vasodilatation is unclear, and there is little information regarding endothelial receptors involved in this effect. Ecto-F -ATPase is a receptor for APOA1, and its activity in endothelial cells is coupled to adenosine diphosphate (ADP)-sensitive P2Y receptors (P2Y ADP receptors). Ecto-F -ATPase is involved in APOA1-mediated cell proliferation and HDL transcytosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13268DOI Listing

Urinary mitochondrial DNA copy number identifies renal mitochondrial injury in renovascular hypertensive patients undergoing renal revascularization: A Pilot Study.

Acta Physiol (Oxf) 2019 Feb 25:e13267. Epub 2019 Feb 25.

Department of Internal Medicine, Divisions of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.

Aims: Patients with renovascular hypertension (RVH) exhibit elevated urinary mtDNA copy numbers, considered to constitute surrogate markers of renal mitochondrial injury. The modest success of percutaneous transluminal renal angioplasty (PTRA) in restoring renal function in RVH has been postulated to be partly attributable to acute reperfusion injury. We hypothesized that mitoprotection during revascularization would ameliorate PTRA-induced renal mitochondrial injury, reflected in elevated urinary mtDNA copy numbers and improve blood pressure and functional outcomes 3 months later. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13267DOI Listing
February 2019
3 Reads

The exaggerated natriuresis of essential hypertension occurs independently of changes in renal medullary blood flow.

Acta Physiol (Oxf) 2019 Feb 15:e13266. Epub 2019 Feb 15.

Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Aims: In patients with essential hypertension, abnormal renal sodium handling includes exaggerated natriuresis in response to extracellular volume expansion. We tested the hypothesis that exaggerated natriuresis is associated with increases in medullary and/or cortical renal blood flow.

Methods: Patients with mild essential hypertension, but no signs of end organ damage, and control subjects were studied after 4 days of dietary standardization (<60 mmol Na  day ) preceded in patients by a 14-day drug washout period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13266DOI Listing
February 2019
1 Read

Listen to your physiologist!

Acta Physiol (Oxf) 2019 Apr 2;225(4):e13265. Epub 2019 Mar 2.

Charité- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13265DOI Listing

Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS.

Acta Physiol (Oxf) 2019 Feb 4:e13264. Epub 2019 Feb 4.

Departament of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, Brazil.

Aim: Parkinson's disease (PD) is a progressive neurodegenerative disease that manifests itself clinically after reaching an advanced pathological stage. Besides motor signals, PD patients present cardiovascular and autonomic alterations. Recent data showed that rats induced to Parkinsonism by 6-hydroxydopamine (6-OHDA) administration in the substantia nigra pars compacta (SNpc) showed lower mean arterial pressure (MAP) and heart rate (HR), as reduction in sympathetic modulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13264DOI Listing
February 2019
2 Reads

Preserved cardiovascular homeostasis despite blunted acetylcholine-induced dilation in mice with endothelial muscarinic M3 receptor deletion.

Acta Physiol (Oxf) 2019 May 18;226(1):e13262. Epub 2019 Feb 18.

Department for Experimental Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Aim: Muscarinic acetylcholine receptors (AChMR1-5) are fundamental for cellular responses upon release of the neurotransmitter acetylcholine (ACh) from parasympathetic nerve fibers. ACh is the prototypical agonist stimulating endothelium-dependent dilation, but most blood vessels lack parasympathetic innervation, raising the question as to the physiologic function of endothelial AChMR in vivo. Global deletion of AChM3R revealed a role in ACh-induced vasodilation in vitro and food uptake, but overall cardiovascular homeostasis has not been examined thoroughly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13262DOI Listing
May 2019
1 Read

DAN plays important compensatory roles in systemic-to-pulmonary shunt associated pulmonary arterial hypertension.

Acta Physiol (Oxf) 2019 Feb 4:e13263. Epub 2019 Feb 4.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Aim: Proteins mainly expressed in normal lungs and significantly changed in lungs exposed to systemic-to-pulmonary shunts might be promising targets for pulmonary arterial hypertension induced by congenital heart diseases (PAH/CHD). This study aimed to investigate the potential role of differential screening-selected gene aberrative in neuroblastoma (DAN) in PAH/CHD.

Methods: PAH was surgically induced by the combined surgery (right pulmonary artery ligation and left cervical systemic-to-pulmonary shunt) in Sprague-Dawley (SD) rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13263DOI Listing
February 2019
4 Reads
4.382 Impact Factor

Did you know developing quantitative pulse diagnosis with realistic haemodynamic theory can pave a way for future personalized health care.

Acta Physiol (Oxf) 2019 Feb 3:e13260. Epub 2019 Feb 3.

Department of Physics, National Taiwan Normal University, Taipei, Taiwan.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13260
Publisher Site
http://dx.doi.org/10.1111/apha.13260DOI Listing
February 2019
4 Reads

Dantrolene sodium increases calcium binding by human recombinant cardiac calsequestrin and calcium loading by sheep cardiac sarcoplasmic reticulum.

Acta Physiol (Oxf) 2019 Feb 1:e13261. Epub 2019 Feb 1.

School of Life Science, La Trobe University, Bundoora, Victoria, Australia.

Aim: Dantrolene interacts with ryanodine receptors in skeletal and cardiac muscle affecting sarcoplasmic reticulum calcium release. Since dantrolene is lipophilic it could also affect intra-sarcoplasmic reticulum calcium handling proteins such as calsequestrin. This study investigated whether dantrolene (1-30 µmol/L) alters the polymerization state and the calcium binding capacity of recombinant cardiac calsequestrin and cardiac sarcoplasmic reticulum calcium handling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13261DOI Listing
February 2019

Kidney damage by iodinated contrast media.

Acta Physiol (Oxf) 2019 Jan 28:e13259. Epub 2019 Jan 28.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Vegetative Physiologie, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13259DOI Listing
January 2019

Obesity, adipocytes and insulin resistance-Friends for life?

Acta Physiol (Oxf) 2019 Mar;225(3):e13258

Experimental Nephrology, KIM III, Universitätsklinikum Jena, Jena, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13258
Publisher Site
http://dx.doi.org/10.1111/apha.13258DOI Listing
March 2019
13 Reads

Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats.

Acta Physiol (Oxf) 2019 Jan 18:e13256. Epub 2019 Jan 18.

Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida.

Aim: Butyrate is a major gut microbiota-derived metabolite. Reduced butyrate-producing bacteria has been reported in the spontaneously hypertensive rat (SHR), a model of hypertension characterized by dysfunctional autonomic nervous system and gut dysbiosis. Here, we demonstrate a potential mechanism for butyrate in blood pressure regulation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13256
Publisher Site
http://dx.doi.org/10.1111/apha.13256DOI Listing
January 2019
15 Reads
4.382 Impact Factor

Investigating brain d-serine: Advocacy for good practices.

Acta Physiol (Oxf) 2019 May 14;226(1):e13257. Epub 2019 Feb 14.

Department of Chemistry, The Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois.

The last two decades have witnessed remarkable advance in our understanding the role of d-amino acids in the mammalian nervous system: from the unknown, to known molecules with unknown functions, to potential central players in health and disease. d-Amino acids have emerged as an important class of signaling molecules. In particular, the exploration of the roles of d-serine in brain physiopathology is a vibrant field that is growing at an accelerating pace. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462235PMC
May 2019
4.382 Impact Factor

Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats.

Acta Physiol (Oxf) 2019 Jan 11:e13255. Epub 2019 Jan 11.

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.

Aim: Chronic intermittent hypoxia (CIH) induces systemic (hypertension) and central alterations (mitochondrial dysfunction underlying cognitive deficits). We hypothesized that agonists of oestradiol receptors (ER) α and β prevent CIH-induced hypertension and brain mitochondrial dysfunction.

Methods: Ovariectomized female rats were implanted with osmotic pumps delivering vehicle (Veh), the ERα agonist propylpyraoletriol (PPT - 30 μg/kg/day) or the ERβ agonist diarylpropionitril (DPN - 100 μg/kg/day). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13255
Publisher Site
http://dx.doi.org/10.1111/apha.13255DOI Listing
January 2019
9 Reads

Hamstring injury risk factors in elite sports: The role of muscle geometry and function.

Acta Physiol (Oxf) 2019 Jan 11:e13253. Epub 2019 Jan 11.

Exercise and Training Science, Department of Performance, Neuroscience, Therapy and Health, MSH Medical School Hamburg, University of Applied Sciences and Medical University, Hamburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13253DOI Listing
January 2019
3 Reads

Searching for ketamine's antidepressant mechanisms: From synaptic plasticity to dentate gyrus cell proliferation.

Authors:
Tomi Rantamäki

Acta Physiol (Oxf) 2019 Apr 28;225(4):e13252. Epub 2019 Jan 28.

Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapeutics, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13252DOI Listing

Acute intrarenal angiotensin (1-7) infusion decreases diabetes-induced glomerular hyperfiltration but increases kidney oxygen consumption in the rat.

Acta Physiol (Oxf) 2019 May 5;226(1):e13254. Epub 2019 Feb 5.

Division of Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Aim: Common kidney alterations early after the onset of insulinopenic diabetes include glomerular hyperfiltration, increased oxygen consumption and tissue hypoxia. Increased activity of the renin-angiotensin-aldosterone system (RAAS) has been implicated in most of these early alterations. The RAAS peptide angiotensin (1-7) has the potential to modulate RAAS-mediated alterations in kidney function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13254DOI Listing
May 2019
1 Read

An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery.

Acta Physiol (Oxf) 2019 Jan 10:e13251. Epub 2019 Jan 10.

Departments of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah.

Background: Mechanisms underlying physical inactivity-induced insulin resistance are not well understood. In addition to a role in muscle repair, immune cell populations such as macrophages may regulate insulin sensitivity.

Aim: The aim of this study was to examine if the dynamic changes in insulin sensitivity during and after recovery from reduced physical activity corresponded to changes in skeletal muscle macrophages. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13251
Publisher Site
http://dx.doi.org/10.1111/apha.13251DOI Listing
January 2019
6 Reads

Doctoral Dissertation: The transient outward potassium current in healthy and diseased hearts.

Authors:
Kirstine Calloe

Acta Physiol (Oxf) 2019 Jan;225 Suppl 717:e13225

Section for Anatomy, Biochemistry and Physiology, Department for Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13225DOI Listing
January 2019

The slow force response to stretch: Controversy and contradictions.

Acta Physiol (Oxf) 2019 May 25;226(1):e13250. Epub 2019 Jan 25.

Department of Physiology, University of Auckland, Auckland, New Zealand.

When exposed to an abrupt stretch, cardiac muscle exhibits biphasic active force enhancement. The initial, instantaneous, force enhancement is well explained by the Frank-Starling mechanism. However, the cellular mechanisms associated with the second, slower phase remain contentious. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13250DOI Listing

The countermeasure for cancer cachexia related muscle wasting does not need to be muscle hyperplasia.

Authors:
Wilhelm Bloch

Acta Physiol (Oxf) 2019 Mar 19;225(3):e13248. Epub 2019 Jan 19.

Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13248DOI Listing

Proteasuria-The impact of active urinary proteases on sodium retention in nephrotic syndrome.

Acta Physiol (Oxf) 2019 Apr 18;225(4):e13249. Epub 2019 Jan 18.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.

Sodium retention and extracellular volume expansion are typical features of patients with nephrotic syndrome. In recent years, from in vitro data, endoluminal activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases has been proposed as an underlying mechanism. Recently, this concept was supported in vivo in nephrotic mice that were protected from proteolytic ENaC activation and sodium retention by the use of aprotinin for the pharmacological inhibition of urinary serine protease activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13249DOI Listing
April 2019
4 Reads

Perinatal free-choice of a high-calorie low-protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood.

Acta Physiol (Oxf) 2018 Dec 27:e13244. Epub 2018 Dec 27.

Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.

Aim: We aimed to investigate whether a dysregulated maternal diet during gestation and lactation induces long-lasting changes in the hypothalamic control of feeding behavior in the offspring and whether this effect is sex specific.

Methods: The study included an analysis of appetite-regulating metabolic hormones and hypothalamic signaling in male and female offspring in adulthood after exposure to a free-choice high-calorie palatable low-protein (P) diet or standard chow (C) during (pre)gestation/lactation (maternal) and/or postweaning (offspring).

Results: Maternal exposure to the P diet resulted in decreased protein intake and body weight gain in dams and decreased body weight gain in offspring during lactation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13244
Publisher Site
http://dx.doi.org/10.1111/apha.13244DOI Listing
December 2018
4 Reads

Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease.

Acta Physiol (Oxf) 2018 Dec 27:e13247. Epub 2018 Dec 27.

Department of Physiology and Pharmacology, Translational Research on Renal and Cardiovascular Diseases (TRECARD), University of Salamanca, Salamanca, Spain.

Aim: Chronic kidney disease is characterized by tubulointerstitial fibrosis involving inflammation, tubular apoptosis, fibroblast proliferation and extracellular matrix accumulation. Cardiotrophin-1, a member of the interleukin-6 family of cytokines, protects several organs from damage by promoting survival and anti-inflammatory effects. However, whether cardiotrophin-1 participates in the response to chronic kidney injury leading to renal fibrosis is unknown. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13247
Publisher Site
http://dx.doi.org/10.1111/apha.13247DOI Listing
December 2018
11 Reads

New evidence for fat as a primary taste quality.

Acta Physiol (Oxf) 2019 May 16;226(1):e13246. Epub 2019 Jan 16.

Department of Otolaryngology, and the Rocky Mountain Taste & Smell Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13246DOI Listing
May 2019
1 Read

Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes.

Acta Physiol (Oxf) 2018 Dec 26:e13245. Epub 2018 Dec 26.

Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Aim: To examine the effect of high-intensity interval training (HIIT) on glucose clearance rates in skeletal muscle and explore the mechanism within the muscle.

Methods: Ten males with type 2 diabetes mellitus (T2DM) and ten matched healthy subjects performed 2 weeks of one-legged HIIT (total of eight sessions, each comprised of 10 × 1 minute ergometer bicycle exercise at >80% of maximal heart rate, interspersed with one min of rest). Insulin sensitivity was assessed by an isoglycaemic, hyperinsulinaemic clamp combined with arteriovenous leg balance technique of the trained (T) and the untrained (UT) leg and muscle biopsies of both legs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13245DOI Listing
December 2018
15 Reads

The synchronized clocks of the host and microbiota.

Authors:
Amanda J Page

Acta Physiol (Oxf) 2019 Mar 12;225(3):e13243. Epub 2019 Jan 12.

Vagal Afferent Research Group, Centre for Nutrition and Gastrointestinal Disease, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13243
Publisher Site
http://dx.doi.org/10.1111/apha.13243DOI Listing
March 2019
3 Reads

Regulation of cardiac myocyte cohesion and gap junctions via desmosomal adhesion.

Acta Physiol (Oxf) 2018 Dec 23:e13242. Epub 2018 Dec 23.

Faculty of Medicine, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany.

Aims: Mutations in desmosomal proteins can induce arrhythmogenic cardiomyopathy with life-threatening arrhythmia. Previous data demonstrated adrenergic signalling to be important to regulate desmosomal cohesion in cardiac myocytes. Here, we investigated how signalling pathways including adrenergic signalling, PKC and SERCA regulate desmosomal adhesion and how this controls gap junctions (GJs) in cardiac myocytes. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/apha.13242
Publisher Site
http://dx.doi.org/10.1111/apha.13242DOI Listing
December 2018
14 Reads
4.382 Impact Factor

CCN1 regulates cholesterol metabolism-OxLDL enters the matrix.

Acta Physiol (Oxf) 2019 Mar 9;225(3):e13239. Epub 2019 Jan 9.

Medical Department II, Heart Center Bonn, University Hospital Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13239
Publisher Site
http://dx.doi.org/10.1111/apha.13239DOI Listing
March 2019
11 Reads

Signal transmission at invaginating cone photoreceptor synaptic contacts following deletion of the presynaptic cytomatrix protein Bassoon in mouse retina.

Acta Physiol (Oxf) 2018 Dec 16:e13241. Epub 2018 Dec 16.

Department of Biology, Animal Physiology, FAU Erlangen-Nürnberg, Erlangen, Germany.

Aim: A key feature of the mammalian retina is the segregation of visual information in parallel pathways, starting at the photoreceptor terminals. Cone photoreceptors establish synaptic contacts with On bipolar and horizontal cells at invaginating, ribbon-containing synaptic sites, whereas Off bipolar cells form flat, non-ribbon-containing contacts. The cytomatrix protein Bassoon anchors ribbons at the active zone, and its absence induces detachment of ribbons from the active zone. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13241
Publisher Site
http://dx.doi.org/10.1111/apha.13241DOI Listing
December 2018
14 Reads

Alpha and omega in potassium-channel opening.

Authors:
Fredrik Elinder

Acta Physiol (Oxf) 2019 Feb 31;225(2):e13240. Epub 2018 Dec 31.

Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apha.13240DOI Listing
February 2019
2 Reads