6,566 results match your criteria Acta Physiologica[Journal]

Gestational diabesity and fetoplacental vascular dysfunction.

Acta Physiol (Oxf) 2021 May 4:e13671. Epub 2021 May 4.

Cellular and Molecular Physiology Laboratory, Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, 8330024, Chile.

Gestational diabetes mellitus (GDM) shows a deficiency in the metabolism of D-glucose and other nutrients, thereby negatively affecting the fetoplacental vascular endothelium. Maternal hyperglycaemia and hyperinsulinemia play an important role in the aetiology of GDM. A combination of these and other factors predisposes women to developing GDM with pre-pregnancy normal weight, viz. Read More

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Did you know? Using entropy and fractal geometry to quantify fluctuations in physiological outputs.

Acta Physiol (Oxf) 2021 Apr 29:e13670. Epub 2021 Apr 29.

Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Kent, UK.

Physiological outputs are characterised by constant fluctuations, even under resting conditions. Quantifying this variability represents an important methodological challenge. Variability in physiological outputs has traditionally been quantified according to its magnitude, using measures such as the standard deviation (SD). Read More

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Unraveling the role of oxytocin in social behaviors mediated by the olfactory system.

Acta Physiol (Oxf) 2021 Apr 29:e13669. Epub 2021 Apr 29.

Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

In the current issue of Acta Physiologica Sun et al. find that oxytocin modulates olfactory signal processing in the main olfactory bulb (MOB). Oxytocin is a cyclic nine amino acid neuropeptide that was first synthesized by biochemist Vincent du Vigneaud (Nobel Prize, 1955). Read More

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Strong ion difference: questionable stewardship.

Peter Bie

Acta Physiol (Oxf) 2021 Apr 26:e13667. Epub 2021 Apr 26.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

A follow-up to a recent discussion of urinary acidity focused on Stewarts's theory of 'strong ion difference' (SID). The comments of Vasileiadis et al. warrant a reevaluation of Stewart's approach. Read More

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Pharmacologic HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation.

Acta Physiol (Oxf) 2021 Apr 26:e13668. Epub 2021 Apr 26.

Section of Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Aim: Hypoxia-inducible factors (HIFs) are O -sensitive transcription factors that regulate multiple biological processes which are essential for cellular adaptation to hypoxia. Small molecule inhibitors of HIF-prolyl hydroxylase domain (PHD) dioxygenases (HIF-PHIs) activate HIF-dependent transcriptional programs and have broad clinical potential. HIF-PHIs are currently in global late-stage clinical development for the treatment of anemia associated with chronic kidney disease. Read More

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Pharmacological inhibition of USP30 activates tissue-specific mitophagy.

Acta Physiol (Oxf) 2021 Apr 23:e13666. Epub 2021 Apr 23.

Departments of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Aim: Mitophagy is the regulated process that targets damaged or dysfunctional mitochondria for lysosomal-mediated removal. This process is an essential element of mitochondrial quality control, and dysregulation of mitophagy may contribute to a host of diseases, most notably neurodegenerative conditions such as Parkinson's disease. Mitochondria targeted for mitophagic destruction are molecularly marked by the ubiquitination of several outer mitochondrial membrane (OMM) proteins. Read More

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Benefits of pharmacological and electrical cholinergic stimulation in hypertension and heart failure.

Acta Physiol (Oxf) 2021 Apr 21:e13663. Epub 2021 Apr 21.

Graduate Program in Pharmaceutical Sciences, Department of Biophysics and Physiology, Federal University of Piaui, Teresina, PI, Brazil.

Systemic arterial hypertension and heart failure are cardiovascular diseases that affect millions of individuals worldwide. They are characterized by a change in the autonomic nervous system balance, highlighted by an increase in sympathetic activity associated with a decrease in parasympathetic activity. Most therapeutic approaches seek to treat these diseases by medications that attenuate sympathetic activity. Read More

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Significant significance?

Acta Physiol (Oxf) 2021 Apr 21:e13665. Epub 2021 Apr 21.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Vegetative Physiology, Berlin, Germany.

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A bird's eye view of the dynamics of pancreatic β-cell heterogeneity.

Acta Physiol (Oxf) 2021 Apr 21:e13664. Epub 2021 Apr 21.

Diabetes and Islet Biology Group, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.

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Dietary influences on the Dahl SS rat gut microbiota and its effects on salt-sensitive hypertension and renal damage.

Acta Physiol (Oxf) 2021 Apr 18:e13662. Epub 2021 Apr 18.

Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Aim: Our previous studies have demonstrated the importance of dietary factors in the determination of hypertension in Dahl salt-sensitive (SS) rats. Since the gut microbiota has been implicated in chronic diseases like hypertension, we hypothesized that dietary alterations shift the microbiota to mediate the development of salt-sensitive hypertension and renal disease.

Methods: This study utilized SS rats from the Medical College of Wisconsin (SS/MCW) maintained on a purified, casein-based diet (0. Read More

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Acidosis-induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells.

Acta Physiol (Oxf) 2021 Apr 11:e13661. Epub 2021 Apr 11.

Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.

Aim: Type A intercalated cells of the renal collecting duct participate in the maintenance of the acid/base balance through their capacity to adapt proton secretion to homeostatic requirements. We previously showed that increased proton secretion stems in part from the enlargement of the population of proton secreting cells in the outer medullary collecting duct through division of fully differentiated cells, and that this response is triggered by growth/differentiation factor 15. This study aimed at deciphering the mechanism of acid load-induced secretion of Gdf15 and its mechanism of action. Read More

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High phosphate impairs arterial endothelial function through AMPK-related pathways in mouse resistance arteries.

Acta Physiol (Oxf) 2021 04 20;231(4):e13595. Epub 2020 Dec 20.

Department of Physiology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.

Aims: In patients with renal disease, high serum phosphate shows a relationship with cardiovascular risk. We speculate that high phosphate (HP) impairs arterial vasodilation via the endothelium and explore potential underlying mechanisms.

Methods: Isolated vessel relaxation, endothelial function, glomerular filtration rate (GFR), oxidative stress status and protein expression were assessed in HP diet mice. Read More

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Insulin as a potent bidirectional regulator of GABAergic signalling in the hippocampus of an Alzheimer's disease mouse model.

Mai Marie Holm

Acta Physiol (Oxf) 2021 Apr 8:e13660. Epub 2021 Apr 8.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

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Hypertension due to loss of water.

Armin Just

Acta Physiol (Oxf) 2021 Apr 5:e13658. Epub 2021 Apr 5.

Physiologisches Institut, Medizinische Fakultät, Albert-Ludwigs-Universität, Freiburg, Germany.

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No functional TRPA1 in cardiomyocytes.

Acta Physiol (Oxf) 2021 Apr 5:e13659. Epub 2021 Apr 5.

Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Aim: There is mounting evidence that TRPA1 has a role in cardiac physiology and pathophysiology. We aim to clarify the site of TRPA1 expression in the heart and in particular whether the channel is expressed in cardiomyocytes.

Methods: Due to the high calcium conductance of TRPA1, and marginal calcium changes being detectable, microfluorimetry in primary mouse cardiomyocytes, and in the cardiomyocyte cell lines H9c2 and HL-1, was applied. Read More

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Macrophage activation in stellate ganglia contributes to lung injury-induced arrhythmogenesis in male rats.

Acta Physiol (Oxf) 2021 Apr 5:e13657. Epub 2021 Apr 5.

Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, USA.

Aim: Patients suffering from acute lung injury (ALI) are at high risk of developing cardiac arrhythmias. We hypothesized that stellate ganglia (SG) neural inflammation contributes to ALI-induced arrhythmia.

Methods: We created an ALI rat model using a single tracheal instillation of bleomycin (2. Read More

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Dichotomous effects on lymphatic transport with loss of caveolae in mice.

Acta Physiol (Oxf) 2021 Apr 1:e13656. Epub 2021 Apr 1.

Division of Lymphatic Biology, Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, TX, USA.

Aim: Fluid and macromolecule transport from the interstitium into and through lymphatic vessels is necessary for tissue homeostasis. While lymphatic capillary structure suggests that passive, paracellular transport would be the predominant route of macromolecule entry, active caveolae-mediated transcellular transport has been identified in lymphatic endothelial cells (LECs) in vitro. Caveolae also mediate a wide array of endothelial cell processes, including nitric oxide regulation. Read More

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Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides.

Acta Physiol (Oxf) 2021 Mar 30:e13655. Epub 2021 Mar 30.

VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA, USA.

Aim: A 'leaky' gut barrier has been implicated in the initiation and progression of a multitude of diseases, e.g., inflammatory bowel disease (IBD), irritable bowel syndrome, and celiac disease. Read More

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Thank you Mikko Nikinmaa!

Pontus B Persson

Acta Physiol (Oxf) 2021 Mar 30:e13654. Epub 2021 Mar 30.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Vegetative Physiology, Berlin, Germany.

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Hans R Ulfendahl (1927-2021)-Obituary.

Acta Physiol (Oxf) 2021 Mar 23:e13653. Epub 2021 Mar 23.

Section of Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

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The Na/K-ATPase α1/Src interaction regulates metabolic reserve and Western diet intolerance.

Acta Physiol (Oxf) 2021 Mar 22:e13652. Epub 2021 Mar 22.

Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, WV, USA.

Aim: Highly prevalent diseases such as insulin resistance and heart failure are characterized by reduced metabolic flexibility and reserve. We tested whether Na/K-ATPase (NKA)-mediated regulation of Src kinase, which requires two NKA sequences specific to the α1 isoform, is a regulator of metabolic capacity that can be targeted pharmacologically.

Methods: Metabolic capacity was challenged functionally by Seahorse metabolic flux analyses and glucose deprivation in LLC-PK1-derived cells expressing Src binding rat NKA α1, non-Src-binding rat NKA α2 (the most abundant NKA isoform in the skeletal muscle), and Src binding gain-of-function mutant rat NKA α2. Read More

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HCN and nicotine.

Acta Physiol (Oxf) 2021 Mar 22:e13651. Epub 2021 Mar 22.

Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia.

As confirmed also in subiculum nicotine may directly modulate the hyperpolarization-activated cyclic nucleotide gated non-selective cation channel - HCN. The latter mirrors findings in interneurons of stratum oriens - SO with axons terminating within the lacunosum moleculare - SLM of hippocampus. It is consistent that the main role of HCN and underlying currents I to some extent is dogmatized, as its functional expression in hippocampus and subiculum does not make them pacemaker regions. Read More

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Diet-induced iron deficiency in rats impacts small intestinal calcium and phosphate absorption.

Acta Physiol (Oxf) 2021 Mar 22:e13650. Epub 2021 Mar 22.

Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.

Aims: Recent reports suggest that iron deficiency impacts both intestinal calcium and phosphate absorption, although the exact transport pathways and intestinal segment responsible have not been determined. Therefore, we aimed to systematically investigate the impact of iron deficiency on the cellular mechanisms of transcellular and paracellular calcium and phosphate transport in different regions of the rat small intestine.

Methods: Adult, male Sprague-Dawley rats were maintained on a control or iron-deficient diet for 2 weeks and changes in intestinal calcium and phosphate uptake were determined using the in situ intestinal loop technique. Read More

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Absence of neocytolysis in humans returning from a 3-week high-altitude sojourn.

Acta Physiol (Oxf) 2021 Mar 17:e13647. Epub 2021 Mar 17.

Medical Clinic VII, Sports Medicine, University Hospital Heidelberg, Heidelberg, Germany.

Aims: Total haemoglobin mass (tot-Hb) increases during high-altitude acclimatization. Normalization of tot-Hb upon descent is thought to occur via neocytolysis, the selective destruction of newly formed erythrocytes. Because convincing experimental proof of neocytolysis is lacking, we performed a prospective study on erythrocyte survival after a stay at the Jungfraujoch Research Station (JFJRS; 3450 m). Read More

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Neuropeptides and neurohormones in immune, inflammatory and cellular responses to ultraviolet radiation.

Acta Physiol (Oxf) 2021 Mar 16:e13644. Epub 2021 Mar 16.

Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

Humans are exposed to varying amounts of ultraviolet radiation (UVR) through sunlight. UVR penetrates into human skin leading to release of neuropeptides, neurotransmitters and neuroendocrine hormones. These messengers released from local sensory nerves, keratinocytes, Langerhans cells (LCs), mast cells, melanocytes and endothelial cells (ECs) modulate local and systemic immune responses, mediate inflammation and promote differing cell biologic effects. Read More

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Non-enzymatic function of prostasin and sodium balance.

Per Svenningsen

Acta Physiol (Oxf) 2021 Mar 15:e13649. Epub 2021 Mar 15.

Department of Molecular Medicine, Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark.

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Interaction between angiotensin II and the renal prostaglandin system in calcineurin inhibitor induced nephrotoxicity.

Kirsten Madsen

Acta Physiol (Oxf) 2021 Mar 13:e13648. Epub 2021 Mar 13.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

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Renal failure in focus.

Isabel Auge

Acta Physiol (Oxf) 2021 Mar 11:e13645. Epub 2021 Mar 11.

Experimentelle Nephrologie, Universitätsklinikum Jena, Jena, Germany.

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AKI and CKD.

Acta Physiol (Oxf) 2021 Mar 8:e13646. Epub 2021 Mar 8.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Vegetative Physiology, Berlin, Germany.

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Deciphering the role of T-type calcium channels in regulating adult hippocampal neurogenesis.

Acta Physiol (Oxf) 2021 Mar 4:e13643. Epub 2021 Mar 4.

Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, Seoul, South Korea.

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