655,635 results match your criteria Acta Physica Slovaca[Journal]


"Mixed" Myeloproliferative Neoplasm Due to Co-Occurrence of Different Driver Mutations.

Authors:
Isabelle Plo

Acta Haematol 2019 Apr 18;141(4):268-270. Epub 2019 Apr 18.

INSERM, UMR1170, Laboratory of Excellence GR-Ex, Villejuif, France,

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http://dx.doi.org/10.1159/000498979DOI Listing

Experimental and theoretical insights on the effect of solvent polarity on the photophysical properties of a benzanthrone dye.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 3;218:221-228. Epub 2019 Apr 3.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Benzanthrone derivatives show interesting solvent dependent photophysical properties. Understanding of their photophysical properties is essential for developing the fluorescence probes based on benzanthrone derivatives. The photophysical properties of 3-(N'-chlorophenyl)piperazino-7H-benzo[de]anthracen-7-one [ClPh-PBA] molecule are reported in different solvents and solvent mixtures. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.001DOI Listing

Altered dynamics may drift pathological fibrillization in membraneless organelles.

Biochim Biophys Acta Proteins Proteom 2019 Apr 15. Epub 2019 Apr 15.

MTA-DE Laboratory of Protein Dynamics, University of Debrecen, Hungary. Electronic address:

Protein phase transition can generate non-membrane bound cellular compartments, which can convert from liquid-like to solid-like states. While the molecular driving forces of phase separation have been largely understood, much less is known about the mechanisms of material-state conversion. We apply a recently developed algorithm to describe the weak interaction network of multivalent motifs, and simulate the effect of pathological mutations. Read More

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http://dx.doi.org/10.1016/j.bbapap.2019.04.005DOI Listing

The nanoscopic molecular pathway through human skin.

Biochim Biophys Acta Gen Subj 2019 Apr 15. Epub 2019 Apr 15.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. Electronic address:

Background: Knowledge regarding the barrier properties of human skin is important for understanding skin pathology, developing of transdermal drug delivery systems and computational skin absorption models; however, the molecular pathways through human skin remains to be fully investigated on a nanoscopic level. In particular the nanoscopic pathway of molecules passing the intercellular lipid bilayers separating the corneocytes in the stratum corneum (SC) is not fully elucidated.

Methods: Using stimulated emission depletion microscopy (STED) and Förster resonance energy transfer (FRET) the molecular pathways through the SC, the main barrier of the skin, are determined for lipophilic and water-soluble molecules at a nanoscopic resolution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044165193008
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http://dx.doi.org/10.1016/j.bbagen.2019.04.012DOI Listing

A gradual change of chromosome mosaicism from placenta to fetus leading to T18 false negative result by NIPS.

Clin Chim Acta 2019 Apr 15. Epub 2019 Apr 15.

Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, China. Electronic address:

Background: Noninvasive prenatal screening (NIPS) has higher sensitivity and specificity compared to traditional prenatal screening. Nevertheless, the discordant results between the NIPS and prenatal diagnosis were occasionally reported. In current study, we investigated the genetic basis of a T18 fetus with a discordant trisomy 5 (T5) positive and trisomy 18 (T18) negative NIPS result. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.064DOI Listing

Leishmaniasis in Istanbul; A new epidemiological data about refugee leishmaniasis.

Acta Trop 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Leishmania is an intracellular parasite, which is transmitted by the bite of infected female Phlebotominae sand flies. Turkey is a crossroad between Europe and Asia that makes it important in terms of epidemiology. In the present study, we aimed to evaluate Leishmania infection among non-autochthonous patients admitted to Health Sciences University, Dr. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X193037
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http://dx.doi.org/10.1016/j.actatropica.2019.04.008DOI Listing
April 2019
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Centenarian hip fracture patients: a nationwide population-based cohort study of 507 patients.

Acta Orthop 2019 Apr 18:1-10. Epub 2019 Apr 18.

d Department of Clinical Biochemistry , Hvidovre Hospital, University of Copenhagen , Hvidovre , Denmark.

Background and purpose - Several studies suggest a global increase of centenarians during the 21st century. We describe temporal trends of hip fracture incidence and mortality in this group and compare these patients with a group of younger hip fracture patients with regards to comorbidities and mortality. Patients and methods - The full study population included all hip fractures that occurred in Denmark (n = 154,047) between 1996 and 2012. Read More

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https://www.tandfonline.com/doi/full/10.1080/17453674.2019.1
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http://dx.doi.org/10.1080/17453674.2019.1602386DOI Listing
April 2019
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Patient-reported outcomes in hip resurfacing versus conventional total hip arthroplasty: a register-based matched cohort study of 726 patients.

Acta Orthop 2019 Apr 18:1-10. Epub 2019 Apr 18.

c Swedish Hip Arthroplasty Register , Gothenburg ;

Background and purpose - The theoretical mechanical advantages of metal-on-metal hip resurfacing (MoM-HR) compared with conventional total hip arthroplasty (THA) have been questioned. Studies including measures of patient-reported function, physical activity, or health-related quality of life have been sparse. We compared patient-reported outcomes in MoM-HR patients with a matched group of patients with conventional THA at 7 years post-surgery. Read More

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http://dx.doi.org/10.1080/17453674.2019.1604343DOI Listing

The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms.

Cephalalgia 2019 Apr 18:333102419840777. Epub 2019 Apr 18.

6 University Medical Center Utrecht, Utrecht University, Department of Oral-Maxillofacial Surgery and Special Dental Care, Utrecht, the Netherlands.

Aim: To systematically review the available literature on the diagnostic accuracy of questionnaires and measurement instruments for headaches associated with musculoskeletal symptoms.

Design: Articles were eligible for inclusion when the diagnostic accuracy (sensitivity/specificity) was established for measurement instruments for headaches associated with musculoskeletal symptoms in an adult population. The databases searched were PubMed (1966-2018), Cochrane (1898-2018) and Cinahl (1988-2018). Read More

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http://dx.doi.org/10.1177/0333102419840777DOI Listing

Assessing the nephrotoxicity of intravenous iodinated contrast agents in patients with chronic renal failure in the absence of interfering acute disease.

Acta Radiol 2019 Apr 18:284185119840764. Epub 2019 Apr 18.

1 Department of Radiology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain.

Background: The existence of contrast-induced nephropathy is widely accepted. Recent studies suggest its incidence has been overestimated.

Purpose: To determine the effect of intravenous iodinated contrast agents on renal function in patients with chronic renal failure without acute disease that can interfere with the assessment of renal function. Read More

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http://dx.doi.org/10.1177/0284185119840764DOI Listing

Wash-in/wash-out phase xenon-enhanced area-detector CT (ADCT): utility for regional ventilation, pulmonary functional loss and clinical stage evaluations of smokers.

Acta Radiol 2019 Apr 18:284185119840647. Epub 2019 Apr 18.

1 Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Xenon (Xe)-enhanced area-detector computed tomography (ADCT) can visualize regional distribution of Xe within the lungs and demonstrate regional ventilation differences in smokers and patients with pulmonary diseases.

Purpose: The purpose of this study was to evaluate the capability of wash-in and wash-out (WI/WO) phase Xe-enhanced ADCT for detecting regional ventilation differences based on underlying lung conditions, pulmonary functional loss evaluation, and clinical stage prediction for smokers with and without chronic obstructive pulmonary disease (COPD).

Material And Methods: The pulmonary function test as well as inspiratory/expiratory unenhanced and WI/WO phase Xe-enhanced ADCT were prospectively administered to a group of 40 smokers consisting of 25 men (mean age ± standard deviation [SD] = 65. Read More

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http://journals.sagepub.com/doi/10.1177/0284185119840647
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http://dx.doi.org/10.1177/0284185119840647DOI Listing
April 2019
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An uncommon intraspinal mass.

Acta Neurol Belg 2019 Apr 17. Epub 2019 Apr 17.

Katholieke Universiteit Leuven Universitaire Ziekenhuizen, Leuven, Belgium.

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http://dx.doi.org/10.1007/s13760-019-01140-4DOI Listing

A review on nanomaterial-based electrochemical, optical, photoacoustic and magnetoelastic methods for determination of uranyl cation.

Mikrochim Acta 2019 Apr 16;186(5):289. Epub 2019 Apr 16.

Department of Chemistry, Razi University, P. O. Box, Kermanshah, 67149-67346, Iran.

This review (with 177 refs) gives an overview on nanomaterial-based methods for the determination of uranyl ion (UO) by different types of transducers. Following an introduction into the field, a first large section covers the fundamentals of selective recognition of uranyl ion by receptors such as antibodies, aptamers, DNAzymes, peptides, microorganisms, organic ionophores (such as salophens, catechols, phenanthrolines, annulenes, benzo-substituted macrocyclic diamides, organophosphorus receptors, calixarenes, crown ethers, cryptands and β-diketones), by ion imprinted polymers, and by functionalized nanomaterials. A second large section covers the various kinds of nanomaterials (NMs) used, specifically on NMs for electrochemical signal amplification, on NMs acting as signal tags or carriers for signal tags, on fluorescent NMs, on NMs for colorimetric assays, on light scattering NMs, on NMs for surface enhanced Raman scattering (SERS)-based assays and wireless magnetoelastic detection systems. Read More

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http://dx.doi.org/10.1007/s00604-019-3426-5DOI Listing

Parathyroid carcinoma, an unusual cause of primary hyperparathyroidism.

Acta Otorrinolaringol Esp 2019 Apr 14. Epub 2019 Apr 14.

Servicio de Otorrinolaringología, Complexo Hospitalario Universitario A Coruña, A Coruña, España.

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https://linkinghub.elsevier.com/retrieve/pii/S00016519193003
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http://dx.doi.org/10.1016/j.otorri.2018.11.001DOI Listing
April 2019
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Development and Validation of Molecular Assays for Limited Tissue Samples.

Acta Cytol 2019 Apr 17:1-8. Epub 2019 Apr 17.

Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

As the value of molecular testing of cancer specimens increases, the number of tests imposed on tumor specimens also increases, often in tension with the amount of tumor material available. To develop and validate molecular assays for limited specimens, there are specific concerns that must be addressed, including DNA quality, quantity, and abundance; the number of targets/ability to multiplex; and the analytical sensitivity and specificity of the assay itself. Ultimately, weighing these considerations during assay validation in the overall context of clinical utility and laboratory workflow is critical for delivering the highest level of personalized care to patients. Read More

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https://www.karger.com/Article/FullText/499109
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http://dx.doi.org/10.1159/000499109DOI Listing
April 2019
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Determination of Circulating Endothelial Cells and Endothelial Progenitor Cells Using Multicolor Flow Cytometry in Patients with Thrombophilia.

Acta Haematol 2019 Apr 17:1-7. Epub 2019 Apr 17.

Institute of Medical Biochemistry and Laboratory Diagnostics, Thrombotic Center, General University Hospital, and First Faculty of Medicine, Charles University, Prague, Czech Republic.

Background/aims: Endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) have been described as markers of endothelial damage and dysfunction in several diseases, including deep venous thrombosis. Their role in patients with known thrombophilia has not yet been evaluated. Both EPCs and CECs represent extremely rare cell populations. Read More

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http://dx.doi.org/10.1159/000499524DOI Listing

Recognition of silver cations by multifarene[2,2] chemosensors with unexpected fluorescence response.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 9;218:213-220. Epub 2019 Apr 9.

Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, China. Electronic address:

Fluorescent chemosensors based on a new macrocyclic compound, multifarene[2,2], with modification by triazole-linked pyrene or anthracene were synthesized. These macrocyclic sensors exhibited high affinity and selectivity toward Ag over other metal ions, with ratiometric or enhanced response of their fluorescence emissions depending upon the substituent species for coordination to Ag, and an unexpected response to a concentration threshold of the metal cations was discovered. The experimental evidences of fluorescence spectra, H NMR titration, IR spectra, and high-resolution mass spectra suggested the coordination behaviors of the sensors with Ag, that is, the 1:1 complexes were formed with moderate association constants of about 10 L·mol, and the sulfur atoms on macrocyclic ligand should affinite to the metal cations. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.011DOI Listing

Perylenequinone-based "turn on" fluorescent probe for hydrogen sulfide with high sensitivity in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Mar 29;218:206-212. Epub 2019 Mar 29.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China. Electronic address:

Hydrogen sulfide (HS) is a kind of gaseous signal molecule in many physiological processes. In order to detect HS, a novel "turn on" fluorescent probe 6,12-dihydroxyperylene-1,7-dione (DPD) was designed and synthesized. The probe DPD is fluorescence silence, while the addition of HS induces an obvious green fluorescence with an obvious color change from dark blue to yellow-green. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193036
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http://dx.doi.org/10.1016/j.saa.2019.03.112DOI Listing
March 2019
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Recyclable fluorescent chemodosimeters based on 8-hydroxyquinoline derivatives for highly sensitive and selective detection of mercury(II) in aqueous media and test strips.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 4;218:196-205. Epub 2019 Apr 4.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:

Four novel highly selective 8-hydroxyquinoline-based fluorescent chemodosimeters (1-4) were synthesized for the rapid analysis of Hg in aqueous solution and on paper strips, which probably attributed to the excited state intramolecular proton transfer (ESIPT) process. Chemodosimeter 1 was evaluated as a Hg-ratiometric fluorescent sensor while others (2, 3 and 4) displayed fluorescence turn-on response for Hg among the various survey metal ions. We demonstrated that chemodosimeters (1-4) could recognized Hg ions based on a 1:1 stoichiometric binding event with fast detection time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193037
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http://dx.doi.org/10.1016/j.saa.2019.04.004DOI Listing
April 2019
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Transient UV-vis absorption spectroscopic characterisation of 2'-methoxyacetophenone as a DNA photosensitiser.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 6;218:191-195. Epub 2019 Apr 6.

Instituto Universitario Mixto de Tecnología Química, Universitat Politècnica de València (UPV-CSIC), Av. Los Naranjos s/n, 46022, Valencia, Spain. Electronic address:

2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting photosensitiser for cyclobutane pyrimidine dimers (CPDs) formation. In the present paper, a complete UV-Vis transient absorption spectroscopic characterisation of this compound is provided, including triplet-triplet spectra, triplet lifetimes and rate constants for quenching of 2M by a dimeric thymine derivative. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.007DOI Listing

Serological and molecular evidence of Bartonella henselae in cats from Luanda city, Angola.

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Oporto, Portugal; EpiUnit, Epidemiology Research Unit, Institute of Public Health of the University of Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Oporto, Portugal. Electronic address:

A total of 100 domestic cats from Luanda (Angola) were tested for the presence of antibodies against Bartonella henselae and spotted fever group of Rickettsia (SFGR) using indirect immunofluorescence assay (IFA). Molecular screening targeting the riboflavin synthase (ribC) gene for Bartonella and outer membrane protein B (ompB) gene for Rickettsia, using conventional PCR and sequencing was also performed in cat´s blood samples. Sixty-six percent of the cats from Luanda had IgG antibodies against Bartonella species but none of them had antibodies against SFGR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183134
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http://dx.doi.org/10.1016/j.actatropica.2019.04.012DOI Listing
April 2019
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Differential proteolytic activity in Anisakis simplexs.s. and Anisakis pegreffii, two sibling species from the complex Anisakis simplexs.l., major etiological agents of anisakiasis.

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Departamento de Parasitología, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain.

Proteolytic activity was studied in two sibling species of Anisakis (Nematoda: Anisakidae), A. simplex s.s. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.003DOI Listing

Evolution of Surgical Treatment of Carotid Artery Stenosis: a single centre observational study.

Acta Chir Belg 2019 Apr 17:1-28. Epub 2019 Apr 17.

a Department of Thoracic and Vascular Surgery , Ghent University Hospital , Ghent , Belgium.

Background: In 2009 and 2011 respectively ESVS and AHA/ASA guidelines recommended to operate patients with a symptomatic carotid artery stenosis within 14 days. This study aimed primarily to determine if an academic hospital has implemented these international guidelines about indication and timing of surgical treatment of carotid stenosis. Secondary, the influence of referral from another hospital on time from symptoms to surgery and the influence of time between neurological event and surgery on 30-day complication rate was studied. Read More

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April 2019
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Automatic stratification of prostate tumour aggressiveness using multiparametric MRI: a horizontal comparison of texture features.

Acta Oncol 2019 Apr 17:1-9. Epub 2019 Apr 17.

a The Sir Peter MacCallum Department of Oncology , The University of Melbourne , Melbourne , Australia.

Background: Previous studies have identified apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can stratify prostate cancer into high- and low-grade disease (HG and LG, respectively). In this study, we consider the improvement of incorporating texture features (TFs) from T2-weighted (T2w) multiparametric magnetic resonance imaging (mpMRI) relative to mpMRI alone to predict HG and LG disease.

Material And Methods: In vivo mpMRI was acquired from 30 patients prior to radical prostatectomy. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1598576DOI Listing

Increasing use of immunotherapy and prolonged survival among younger patients with primary CNS lymphoma: a population-based study.

Acta Oncol 2019 Apr 17:1-10. Epub 2019 Apr 17.

a Institute of Neurology , Medical University of Vienna , Vienna , Austria.

Background: Primary CNS lymphoma is a highly aggressive and rare type of extranodal non-Hodgkin lymphoma. Although, new therapeutic approaches have led to improved survival, the management of the disease poses a challenge, practice patterns vary across institutions and countries, and remain ill-defined for vulnerable patient subgroups.

Material And Methods: Using information from the Austrian Brain Tumor Registry we followed a population-based cohort of 189 patients newly diagnosed from 2005 to 2010 through various lines of treatment until death or last follow-up (12-31-2016). Read More

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http://dx.doi.org/10.1080/0284186X.2019.1599137DOI Listing

Survival of 11,390 Continuum cups in primary total hip arthroplasty based on data from the Finnish Arthroplasty Register.

Acta Orthop 2019 Apr 17:1-10. Epub 2019 Apr 17.

a Department of Orthopaedic Surgery , University of Turku and Turku University Hospital , Turku.

Background and purpose - The use of trabecular metal (TM) cups for primary total hip arthroplasty (THA) is increasing. Some recent data suggest that the use of TM in primary THA might be associated with an increased risk of revision. We compared implant survival of Continuum acetabular cups with other commonly used uncemented cups. Read More

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https://www.tandfonline.com/doi/full/10.1080/17453674.2019.1
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http://dx.doi.org/10.1080/17453674.2019.1603596DOI Listing
April 2019
1 Read

Patient-reported 1-year outcome not affected by body mass index in 3,327 total knee arthroplasty patients.

Acta Orthop 2019 Apr 17:1-9. Epub 2019 Apr 17.

b The Swedish Knee Arthroplasty Register , Lund , Sweden.

Background and purpose - Patient-reported outcome (PRO) in total knee arthroplasty (TKA) patients with high body mass index (BMI) is controversial. We compared pain, function, quality of life, general health, and satisfaction among different BMI categories preoperatively and 1 year after primary TKA. Patients and methods - 4,318 patients were operated with a TKA for knee osteoarthritis in the Region of Skane in 2013-2015. Read More

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https://www.tandfonline.com/doi/full/10.1080/17453674.2019.1
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http://dx.doi.org/10.1080/17453674.2019.1604940DOI Listing
April 2019
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Minor influence of patient education and physiotherapy interventions before total hip replacement on patient-reported outcomes: an observational study of 30,756 patients in the Swedish Hip Arthroplasty Register.

Acta Orthop 2019 Apr 17:1-9. Epub 2019 Apr 17.

a Department of Orthopaedics, Institute of Clinical Sciences , Sahlgrenska Academy, University of Gothenburg , Gothenburg ;

Background and purpose - It is unclear whether physiotherapy interventions or patient education before total hip replacement (THR) is beneficial for patients postoperatively. Utilizing the Swedish Hip Arthroplasty Register (SHAR), we retrospectively studied the influence of preoperative self-reported exposure to physiotherapy and/or patient education on patient-reported outcomes 1 year after THR. Patients and methods - Data covering all THRs performed in Sweden for osteoarthritis, between the years 2012 and 2015, was obtained from SHAR. Read More

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https://www.tandfonline.com/doi/full/10.1080/17453674.2019.1
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http://dx.doi.org/10.1080/17453674.2019.1605669DOI Listing
April 2019
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Prevalence of temporomandibular disorder pain, jaw noises and oral behaviors in an adult Italian population sample.

J Oral Rehabil 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurosciences, Reproductive Sciences and Oral Sciences, Division of Orthodontics, University of Naples "Federico II", Naples, Italy.

Objectives: to evaluate the prevalence of temporomandibular disorder pain (TMD-pain), temporomandibular joint (TMJ) noises, and oral behaviors in an Italian adult population sample, and their possible association with gender, oral behaviors, self-reported facial trauma and orthodontic treatment.

Methods: Subjects older than 18 years were recruited from general population in public spaces during their daily life. A specific questionnaire was developed to collect data on TMD-pain, TMJ noises, oral behaviors, orthodontic treatment and facial trauma. Read More

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http://dx.doi.org/10.1111/joor.12803DOI Listing

The effect of myo-inositol/di-chiro-inositol on markers of ovarian reserve in women with PCOS undergoing IVF/ICSI: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2019 Apr 16. Epub 2019 Apr 16.

Women's Health and Perinatology Research Group, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.

Introductio: High levels of anti-Mullerian hormone and a high antral follicle count in women with polycystic ovary syndrome, reflecting increased ovarian antral follicles, predisposes them to have a high number of retrieved oocytes at in-vitro fertilisation (IVF)/ intra-cytoplasmic sperm injection (ICSI) and an increased risk of ovarian hyperstimulation syndrome. Inositols, which act as insulin sensitizers have the potential to alter folliculogenesis and the functional ovarian reserve with subsequent benefits to reproductive outcomes following IVF/ICSI treatment. Published literature is however unable to provide definitive evidence of its efficacy. Read More

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http://dx.doi.org/10.1111/aogs.13625DOI Listing

Buccally Absorbed vs Intravenous Prochlorperazine for Treatment of Migraines Headaches.

Acta Neurol Scand 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Los Angeles, US.

Objective: To compare the efficacy of buccally absorbed prochlorperazine (BAP) to intravenous prochlorperazine (IVP) for the abortive treatment of migraine headaches.

Methods: Randomized double-blind trial. Eighty subjects aged 18-65 presenting with migraines to the ED of a safety-net, urban hospital. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13104
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http://dx.doi.org/10.1111/ane.13104DOI Listing
April 2019
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The Cornell Assessment of Pediatric Delirium: Translation and inter-rater reliability in a Danish pediatric intensive care unit.

Acta Anaesthesiol Scand 2019 Apr 17. Epub 2019 Apr 17.

Department of Anesthesiology and Intensive Care, East Section, Aarhus University Hospital, Aarhus, Denmark.

Background: Delirium is a serious medical problem and recognized as a common syndrome in critically ill children. Without routine screening, delirium diagnosis is often missed by the medical providers. Internationally, there are tools to assess pediatric delirium (PD), but none currently available in Danish. Read More

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http://dx.doi.org/10.1111/aas.13369DOI Listing

Baseline neutrophil-to-lymphocyte ratio is associated with long-term T2D remission after metabolic surgery.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132, Genoa, Italy.

Aims: Metabolic surgery is considered as a therapeutic option for obese patients with type 2 diabetes (T2D). In order to identify novel laboratory variables that could improve the selection of patients who might greatly benefit from a surgical approach, we focused on the neutrophil-to-lymphocyte ratio (NLR) as a predictor of long-term T2D remission following metabolic surgery.

Methods: Thirty-one obese patients with T2D included in this pilot study underwent Roux-en-Y gastric bypass or biliopancreatic diversion (BPD) at the Surgical Department of Genoa University, IRCCS Ospedale Policlinico San Martino in Genoa (Italy). Read More

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http://dx.doi.org/10.1007/s00592-019-01345-2DOI Listing

High level of clinical inertia in insulin initiation in type 2 diabetes across Central and South-Eastern Europe: insights from SITIP study.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia.

Aims: Little is known regarding initiation of insulin therapy in type 2 diabetes (T2D) in Central and South-Eastern European countries. Therefore, we conducted a survey to characterise the prescribing practices of specialist diabetes healthcare professionals in this region and assessed factors that influence clinical decision-making regarding insulin initiation in T2D.

Methods: A cross-sectional survey sampled 211 specialist diabetes healthcare prescribers from five Central and South-Eastern European countries (Bulgaria, Croatia, Greece, Hungary, and Slovenia). Read More

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http://dx.doi.org/10.1007/s00592-019-01346-1DOI Listing

Effects of exenatide long-acting release on cardiovascular events and mortality in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.

Aims: Patients with type 2 diabetes (T2D) have an increased risk of cardiovascular disease. Recent cardiovascular outcome trials (CVOTs) with liraglutide, semaglutide, and albiglutide have shown significant reduction in major adverse cardiovascular events. Conversely, the CVOT with exenatide long-acting release (ELAR) confirmed cardiovascular safety of the drug, but did not reached superiority versus placebo. Read More

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http://dx.doi.org/10.1007/s00592-019-01347-0DOI Listing

Ca signals triggered by bacterial pathogens and microdomains.

Biochim Biophys Acta Mol Cell Res 2018 Nov 18;1865(11 Pt B):1838-1845. Epub 2018 Aug 18.

Université Paris Sud, UMRS1174, Orsay F-91405, France; Institut National de la Santé et de la Recherche Médicale (Inserm), UMRS1174, Orsay F-91405, France. Electronic address:

Recent reports have highlighted the pivotal role of Ca during host cell infection by bacterial pathogens. Here, we review how bacterial pore-forming toxins (PFTs) trigger global Ca signals to regulate cell adhesion-, inflammatory- or death processes. We comment recent reports describing the role of bacterial effectors injected by a type III secretion system (T3SS) as well as host cell players in the formation of Ca microdomains during Shigella invasion and Chlamydia extrusion of host cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183026
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http://dx.doi.org/10.1016/j.bbamcr.2018.08.007DOI Listing
November 2018
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Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways.

Biochim Biophys Acta Mol Cell Res 2018 Nov 9;1865(11 Pt B):1718-1732. Epub 2018 Aug 9.

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA; UCI Center for Autism Research and Translation, School of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Pediatrics, Section of Human Genetics and Genomics, University of California, Irvine, Irvine, CA, USA. Electronic address:

Autism spectrum disorder (ASD) is a group of complex, neurological disorders that affect early cognitive, social, and verbal development. Our understanding of ASD has vastly improved with advances in genomic sequencing technology and genetic models that have identified >800 loci with variants that increase susceptibility to ASD. Although these findings have confirmed its high heritability, the underlying mechanisms by which these genes produce the ASD phenotypes have not been defined. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2018.08.003DOI Listing
November 2018

Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii.

Biochim Biophys Acta Mol Cell Res 2018 Nov 10;1865(11 Pt B):1846-1856. Epub 2018 Aug 10.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address:

Toxoplasma gondii has a complex life cycle involving different hosts and is dependent on fast responses, as the parasite reacts to changing environmental conditions. T. gondii causes disease by lysing the host cells that it infects and it does this by reiterating its lytic cycle, which consists of host cell invasion, replication inside the host cell, and egress causing host cell lysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183025
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http://dx.doi.org/10.1016/j.bbamcr.2018.08.004DOI Listing
November 2018
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The levator claviculae muscle.

Acta Otorrinolaringol Esp 2019 Apr 13. Epub 2019 Apr 13.

Servicio de Otorrinolaringología, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Barcelona, España.

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http://dx.doi.org/10.1016/j.otorri.2018.12.003DOI Listing

Spontaneous emissions between the aΠ, bΣ, cΣ, dΠ, and eΣ states of the AlO cation.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 8;218:184-190. Epub 2019 Apr 8.

College of Physics and Material Science, Henan Normal University, Xinxiang 453007, China. Electronic address:

The potential energy curves are calculated for the aΠ, bΣ, cΣ, dΠ, and eΣ states of the AlO cation using the valence internally contracted multireference configuration interaction approach. The transition dipole moments are computed between these states. To improve the reliability and accuracy of the potential energy curves, several corrections are included, namely, Davidson correction, core-valence correlation and scalar relativistic corrections, as well as extrapolation of the potential energies to the complete basis set limit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193037
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http://dx.doi.org/10.1016/j.saa.2019.04.002DOI Listing
April 2019
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Improving the accuracy and precision of broadband optical cavity measurements.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 10;218:178-183. Epub 2019 Apr 10.

School of Chemistry & Environmental Research Institute, University College Cork, Cork, Ireland; Atmospheric Chemistry Department (ACD), Leibniz Institute for Tropospheric Research (TROPOS), 04318 Leipzig, Germany. Electronic address:

Most extinction measurements require a stable light source to attain high precision and accuracy. Here, we present a convenient approach to normalize light source intensity in broadband optical cavity measurements. In the absence of sample extinction, we show that the in-band signal - the high finesse spectral region of the optical cavity in which sample extinction is measured with high sensitivity - is strongly correlated with the out-of-band signal. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.015DOI Listing

A colorimetric and fluorescent chemosensor based on diarylethene for simultaneous detection and discrimination of biothiols.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 4;218:171-177. Epub 2019 Apr 4.

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi 330013, PR China. Electronic address:

In this work, a novel probe D-HBT-NBD (1O) based on diarylethene to detect biothiols (including Cys, Hcy and GSH) was synthesized and the relative colorimetric and fluorescent properties were tested. The probe exhibited excellent photochromic properties and showed apparent colorimetric and fluorescent signals for Cys, Hcy and GSH. The probe can selectively detect Cys, Hcy and GSH by naked eyes for its open-ring isomer 1O and can discriminate Cys from Hcy/GSH by apparent color change from light orange to dark pink at the closed-ring state under the irradiation of UV light. Read More

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http://dx.doi.org/10.1016/j.saa.2019.03.095DOI Listing

Soil-transmitted helminthiases in Nepal: transmission boundaries and implications for local communities and international travelers.

Acta Trop 2019 Apr 13. Epub 2019 Apr 13.

Department of Cardiac, Thoracic and Vascular Sciences & Public Health, Unit of Hygiene and Public Health, University of Padua. Via L. Loredan, 18 - 35131 Padua, Italy. Electronic address:

Soil transmitted helminthiasis (STHs) are endemic in Nepal but since the country territory is extremely heterogeneous, a multidisciplinary assessment is required to evaluate the risk of infection in different areas. Prevalence data were retrieved with systematic literature search and geographical coordinates were assigned to each survey site. Spatial stratification was then implemented considering land use and ecological parameters. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.014DOI Listing

New insight into phase behavior and permeability of skin lipid models based on sphingosine and phytosphingosine ceramides.

Biochim Biophys Acta Biomembr 2019 Apr 13. Epub 2019 Apr 13.

Division BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Netherlands. Electronic address:

The intercellular lipid matrix of the stratum corneum (SC), which consist mainly of ceramides (CERs), free fatty acids and cholesterol, is fundamental to the skin barrier function. These lipids assemble into two lamellar phases, known as the long and short periodicity phases (LPP and SPP respectively). The LPP is unique in the SC and is considered important for the skin barrier function. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.04.005DOI Listing

A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats.

Acta Otolaryngol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Department of Otolaryngology , Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.

Background: Unilateral labyrinthectomy (UL) causes the disappearance of ipsilateral medial vestibular nuclear (ipsi-MVe) activity and induces spontaneous nystagmus (SN), which disappears during the initial process of vestibular compensation (VC). Ipsi-MVe-activity restores in the late process of VC.

Objective: We evaluated the late process of VC after UL in rats and examined the effects of thioperamide (H3 antagonist) on VC. Read More

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http://dx.doi.org/10.1080/00016489.2019.1599140DOI Listing

Niche definition and guidance for detailed niche evaluation.

Acta Obstet Gynecol Scand 2019 Apr 15. Epub 2019 Apr 15.

Department of Gynecology and Obstetrics, Research institute "Reproduction and Development", Amsterdam UMC, location VU medical center, Amsterdam, The Netherlands.

With interest we read the correspondence of Bamberg et al. and Scioscia et al. about the randomized controlled trial of the first authors concerning the uterine niche after caesarean section (CS). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aogs.13623
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http://dx.doi.org/10.1111/aogs.13623DOI Listing
April 2019
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Mental imagery training for treatment of central neuropathic pain: a narrative review.

Acta Neurol Belg 2019 Apr 15. Epub 2019 Apr 15.

Amity Institute of Neuropsychology and Neurosciences (AINN), Amity University UP, Room No. 222A, J1 Block, Sector 125, Noida, 201303, India.

Mental imagery is a quasi-perceptual experience in the absence of external stimuli. This concept has intrigued psychologists, sportspersons, neurologists and other scientists for over a decade now. Imagery has been used in rehabilitation and the results have been promising. Read More

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http://link.springer.com/10.1007/s13760-019-01139-x
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http://dx.doi.org/10.1007/s13760-019-01139-xDOI Listing
April 2019
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Effects of resveratrol in the signaling of neuropathic pain involving P2X3 in the dorsal root ganglion of rats.

Acta Neurol Belg 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmaceutics, the First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, People's Republic of China.

Neuropathic pain is a major public health problem because it has a considerable impact on life quality of patients. Neuropathic pain caused by a lesion or disease of the somatosensory nervous system, which causes unpleasant and abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), and pain in response to a stimulus that does not normally provoke pain (allodynia). P2X receptors from dorsal root ganglion (DRG) play a crucial role in facilitating pain transmission at peripheral and spinal sites. Read More

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http://dx.doi.org/10.1007/s13760-019-01126-2DOI Listing

Fluorometric determination of HIV DNA using molybdenum disulfide nanosheets and exonuclease III-assisted amplification.

Mikrochim Acta 2019 Apr 15;186(5):286. Epub 2019 Apr 15.

Laboratory of Biometrology, Shanghai Institute of Measurement and Testing Technology, Shanghai, 201203, People's Republic of China.

A convenient and ultrasensitive fluorometric method is described for the determination of HIV DNA. It exploits the strong difference in the affinities of MoS nanosheets for long ssDNA versus short oligonucleotide fragments. In addition, efficient signal amplification is accomplished by exonuclease III-assisted target recycling. Read More

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http://dx.doi.org/10.1007/s00604-019-3368-yDOI Listing

Fluorometric turn-on detection of ascorbic acid based on controlled release of polyallylamine-capped gold nanoclusters from MnO nanosheets.

Mikrochim Acta 2019 Apr 13;186(5):282. Epub 2019 Apr 13.

College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China.

A fluorometric turn-on assay is described for ascorbic acid (AA). It is based on the controlled release of polyallylamine-stabilized gold nanoclusters (polyallylamine-AuNCs) from MnO nanosheets. In an aqueous solution of near-neutral pH value, the positively charged capped AuNCs are adsorbed on the surface of the negatively charged MnO nanosheets. Read More

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http://dx.doi.org/10.1007/s00604-019-3399-4DOI Listing
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