675,044 results match your criteria Acta Physica Slovaca[Journal]


A near-infrared fluorescent probe for imaging of nitroxyl in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 3;241:118680. Epub 2020 Jul 3.

College of Materials Science and Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, China.

A BODIPY-based NIR fluorescent probe, NitroxylBDP, for the rapid and specific, detection of HNO has been designed and synthesized. The merits of NIR fluorescence, and stable fluorescence output against pH changes, and good membrane permeability, enable the probe to serve as an ideal indicator for tracking HNO in living systems. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118680DOI Listing

A dual thiourea-appended perylenebisimide "turn-on" fluorescent chemosensor with high selectivity and sensitivity for Hg in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118678. Epub 2020 Jul 2.

Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China. Electronic address:

Sensing heavy metal ions particularly for the most toxic Hg is a long-term pursuit for chemists because of its obvious and extreme harmfulness to both the environment and human health. Herein, a novel 'turn-on' perylenebisimide-thiourea fluorescent probe PBI-BTB is achieved for rapid detection of Hg in a DMSO/HO (5/1, v/v) solution through a typical Hg-promoting desulfurization reaction, which has been investigated through Job's plot titration, FT-IR, H NMR and HRMS analysis. A remarkable fluorescence emission enhancement at 540 and 580 nm is observed in the presence of Hg, which is visible to the naked eye with high selectivity and sensitivity. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118678DOI Listing

A template of cellulose acetate polymer-ZnAl/C layered double hydroxide composite fabricated with Ni NPs: Applications in the hydrogenation of nitrophenols and dyes degradation.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118671. Epub 2020 Jul 2.

Chemistry Department, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia. Electronic address:

In this work, cellulose acetate polymer (CA) sheet and 2% ZnAl grafted on activated carbon grown in the form of layered double hydroxide (ZnAl/C-LDH) incorporated into CA polymer (CA-ZA2) 5 wt% (CA-ZA5) and 10 wt% of ZnAl/C-LDH (CA-ZA10) sheets were synthesized by simple casting method. All the stated sheets were fabricated with zero-valent Ni nanoparticles by adsorption of Ni ions followed by subsequent reduction with NaBH and named as CA@Ni, CA-ZA2@Ni, CA-ZA5@Ni, and CA-ZA10@Ni NPs. The synthesized Ni NPs were investigated through FESEM, FTIR, XRD and EDS techniques. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118671DOI Listing

Influence of Ag and Mn ions on structural, optical and photoluminescence features of ZnS quantum dots.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118666. Epub 2020 Jul 2.

Universidad de la Costa, Barranquilla, Colombia.

The current study deals with the structural, morphological, elemental, optical and photoluminescence behaviors of Ag, Mn dual doped ZnS quantum dots (QDs). The X-ray diffraction (XRD) and Transmission Electron Microscope (TEM) studies confirmed the cubic structure and size of the crystallites (~2 nm). The Scanning Electron Microscope (SEM) photographs portrayed the surface and morphological structure of prepared samples. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118666DOI Listing

A novel AIE active NIR fluorophore based triphenylamine for sensing of Hg and CN and its multiple application.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118664. Epub 2020 Jul 2.

Department of Chemistry, Shanxi Normal University, Linfen 041004, China. Electronic address:

New strategies still need to be proposed that can be used to sense and remove toxic environmental pollutants in a sensing system. In this research, a novel NIR fluorescence sensor 1 was designed and prepared with aggregation induced emission (AIE) property. The fluorescence intensity of the sensor 1 in DMSO/HO mixed solvent was changed along with the proportion of water. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118664DOI Listing

A colorimetric chemosensor for pyrophosphate based on mono-pyrenylurea in aqueous media.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 3;241:118658. Epub 2020 Jul 3.

College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar, Heilongjiang 161006, PR China. Electronic address:

Research on pyrophosphate ions detection remains important because it plays crucial roles in various fields. A simple and new colorimetric sensor for pyrophosphate (PPi) based on mono-pyrenylurea ligand (L) has been designed and synthesized by a simple reaction of 1-pyrenemethylamine hydrochloride with p-nitrophenylisocyanate. In DMSO-15% HO solution and DMSO-15% HEPES (10 mM, pH = 7. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118658DOI Listing

Magnetic restricted-access carbon nanotubes for the extraction/pre-concentration of organophosphates from food samples followed by spectrophotometric determination.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 20;241:118632. Epub 2020 Jun 20.

Institute of Chemistry, Federal University of Alfenas, 37130-000 Alfenas, MG, Brazil. Electronic address:

In this work, magnetic restricted-access carbon nanotubes (M-RACNTs) were synthesized, characterized and used in the dispersive solid-phase extraction (d-SPE) of organophosphate pesticides (OPPs) from food samples (broccoli, eggplant, cauliflower, and soy milk), followed by spectrophotometric determination in a flow injection analysis system. FeO nanoparticles were incorporated in the multi-walled carbon nanotubes employing dimethylformamide. The dimethylformamide was used as a solvent in the incorporation process, forming the suspension of both particles. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118632DOI Listing

Mercuric ion detection by plasmon-enhanced spectrophotometric ellipsometer using specific oligonucleotide probes.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118682. Epub 2020 Jul 2.

Bilecik Seyh Edebali University, Faculty of Engineering, Bioengineering Department, Bilecik, Turkiye. Electronic address:

Pollution due to heavy metal ions, including mercury, has become a major issue because of their toxicities. It is required to monitor mercury levels in aqueous media using fast and selective methods with high accuracy. Ellipsometry is a promising technique for instance when it's combined with the plasmon resonance phenomena. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118682DOI Listing

Targeting lactate production and efflux in prostate cancer.

Biochim Biophys Acta Mol Basis Dis 2020 Jul 7:165894. Epub 2020 Jul 7.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus of Gualtar, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal. Electronic address:

Prostate cancer (PCa) is the most commonly diagnosed cancer in men worldwide. Screening and management of PCa remain controversial and, therefore, the discovery of novel molecular biomarkers is urgently needed. Alteration in cancer cell metabolism is a recognized hallmark of cancer, whereby cancer cells exhibit high glycolytic rates with subsequent lactate production, regardless of oxygen availability. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165894DOI Listing

Missense mutations affecting Ca-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties.

Biochim Biophys Acta Mol Cell Res 2020 Jul 7:118794. Epub 2020 Jul 7.

Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, I-37134 Verona, Italy. Electronic address:

Guanylate cyclase activating protein 1 (GCAP1) is a neuronal calcium sensor (NCS) involved in the early biochemical steps underlying the phototransduction cascade. By switching from a Ca-bound form in the dark to a Mg-bound state following light activation of the cascade, GCAP1 triggers the activation of the retinal guanylate cyclase (GC), thus replenishing the levels of 3',5'-cyclic monophosphate (cGMP) necessary to re-open CNG channels. Here, we investigated the structural and functional effects of three missense mutations in GCAP1 associated with cone-rod dystrophy, which severely perturb the homeostasis of cGMP and Ca. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118794DOI Listing

The readily transformable Impatiens walleriana efficiently attracts nectar feeding with Aedes and Culex mosquitoes in simulated outdoor garden settings in Mississippi and Florida.

Acta Trop 2020 Jul 7:105624. Epub 2020 Jul 7.

Department of Biology, Baylor University, One Bear Place #7388, Waco, Texas, 76798, USA. Electronic address:

Mosquitoes rely upon plant nectars for their energy needs, a trait that has the potential to allow nectar to serve as a platform for producing and delivering toxins to nuisance and/or vector mosquito species. Impatiens walleriana (Order: Ericales, Family: Balsaminaceae) is a readily transformable and widely planted nectar plant that has been previously shown to attract mosquito nectar-feeding. However, those feeding studies were only conducted indoors and did not test if variable environmental conditions will affect nectar feeding. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105624DOI Listing

Three new species of the Simulium (Simulium) striatum species-group (Diptera: Simuliidae) from Thailand, with their phylogenetic relationships.

Acta Trop 2020 Jul 7:105625. Epub 2020 Jul 7.

Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address:

Three new species of black flies from Thailand, Simulium wangkwaiense, S. tadtonense and S. maeklongkeense, are described based on their adults, pupal exuviae and cocoons. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105625DOI Listing

Essential oil based controlled-release non-toxic evaporating tablet provides effective repellency against Musca domestica.

Acta Trop 2020 Jul 7:105620. Epub 2020 Jul 7.

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, Assam, India.

Housefly, Musca (M) domestica L. (Diptera: Muscidae) is a pervasive insect that transmits a variety of pathogens to humans and livestock. Although numerous synthetic pesticides are available to combat houseflies, their ecological and toxicological concerns have led to the exploration of natural products as safer alternatives. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105620DOI Listing

S-allyl cysteine: A potential compound against skeletal muscle atrophy.

Biochim Biophys Acta Gen Subj 2020 Jul 7:129676. Epub 2020 Jul 7.

Skeletal Muscle Laboratory, Institute of Integrated and Honors Studies, Kurukshetra University, Kurukshetra, Haryana 136119, India. Electronic address:

Background: Oxidative stress is crucial player in skeletal muscle atrophy pathogenesis. S-allyl cysteine (SAC), an organosulfur compound of Allium sativum, possesses broad-spectrum properties including immuno- and redox-modulatory impact. Considering the role of SAC in regulating redox balance, we hypothesize that SAC may have a protective role in oxidative-stress induced atrophy. Read More

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http://dx.doi.org/10.1016/j.bbagen.2020.129676DOI Listing

On the use of lymphocyte to neutrophil ratios in laboratory medicine.

Clin Chim Acta 2020 Jul 7. Epub 2020 Jul 7.

Dept. of Diagnostic Sciences, Ghent University, Belgium; Dept. of Internal Medicine, Ghent University, Belgium.

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http://dx.doi.org/10.1016/j.cca.2020.07.008DOI Listing

Prevalence of elevated liver enzymes and comorbidities in children and adolescents with overweight and obesity.

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Institute of Liver Diseases, Lady Davis Carmel Medical Center, Haifa, Israel.

Aim: We investigated the prevalence of elevated liver aminotrasferases (ALT) and additional comorbidities in a large cohort of Israeli children and adolescents with overweight and obesity.

Methods: This study included data from medical records of 2 to 18 year old children and adolescents, with body mass index (BMI) in the overweight or obesity range (WHO definitions), for whom ALT testing was performed.

Results: Overweight was present in 50418 (10. Read More

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http://dx.doi.org/10.1111/apa.15469DOI Listing

Multi-centre Spanish study found no incidences of viral transmission in infants born to mothers with COVID-19.

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Department of Neonatology, Clínico San Carlos University Hospital, Madrid, Spain.

Aim: Our aim was to describe the clinical features of mothers infected with COVID-19 and examine any potential vertical mother to newborn transmission. We also assessed how effective the discharge recommendations were in preventing transmission during the first month of life.

Methods: This multicentre descriptive study involved 16 Spanish hospitals. Read More

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http://dx.doi.org/10.1111/apa.15474DOI Listing

Neonatal jaundice, attention deficit hyperactivity disorder and familial effects. A Swedish register study with sibling analysis.

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Aim: Neonatal jaundice is associated with higher risk of attention deficit hyperactivity disorder (ADHD), but it is unclear if the association is influenced by genetic and other familial factors. In this large population-based study, we investigated the association between neonatal jaundice and ADHD while adjusting for familial factors.

Methods: We linked several Swedish registers to identify all singleton births without congenital malformations between 1992 and 2000 (n=814,420, including 384,290 full siblings) and followed them up until 2009. Read More

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http://dx.doi.org/10.1111/apa.15475DOI Listing

Uterocervical angle as a predictor of preterm birth on a high risk collective between 20 and 31 weeks of gestation: a cohort analysis.

Acta Obstet Gynecol Scand 2020 Jul 10. Epub 2020 Jul 10.

Department of Obstetrics and Gynecology, Rostock University Medical Center, Rostock, Germany.

Introduction: The cervical length (CL) measurement is a widely used method to estimate the risk of preterm birth. In particular due to the high false-positive rate the establishment of markers with improved test characteristics is a great challenge. A potential predictor of preterm birth is the uterocervical angle (UCA) and an additional measurement may improve the risk assessment. Read More

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http://dx.doi.org/10.1111/aogs.13955DOI Listing

Fetal dynamic magnetic resonance imaging using Doppler ultrasound gating for the assessment of the aortic isthmus: a feasibility study.

Acta Obstet Gynecol Scand 2020 Jul 10. Epub 2020 Jul 10.

Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Introduction: Cardiovascular magnetic resonance imaging (MRI) is established in the cardiac evaluation in postnatal life, but its application to the fetus has been hampered by technical limitations. We aimed to investigate the feasibility of dynamic (MRI) of the fetal aortic isthmus using a magnetic resonance-compatible Doppler ultrasound device for cardiac gating.

Material And Methods: This prospective study included 19 fetuses at a median gestational age of 32. Read More

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http://dx.doi.org/10.1111/aogs.13957DOI Listing

Is there a role for repeating PSMA PET/CT after a negative scan in biochemical recurrent prostate cancer?

Acta Oncol 2020 Jul 10:1-4. Epub 2020 Jul 10.

Urology Department, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1080/0284186X.2020.1790655DOI Listing

Th17/Treg imbalance modulates rat myocardial fibrosis and heart failure by regulating LOX expression.

Acta Physiol (Oxf) 2020 Jul 10:e13537. Epub 2020 Jul 10.

Department of Cardiology, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan, 450003, China.

Aim: The imbalance of T helper (Th) 17/ T regulatory (Treg) is involved in chronic heart failure (HF). The enzyme lysyl oxidase (LOX) contributes to myocardial fibrosis. This study was designed to decipher the regulatory mechanism of Th17/Treg on LOX expression and to validate whether Th17/Treg imbalance regulates myocardial fibrosis by modulating LOX expression. Read More

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http://dx.doi.org/10.1111/apha.13537DOI Listing

Early term elective Caesarean sections did not increase the risk of behavioural problems at six to eight years of age.

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Perinatal Epidemiology Research Unit, Aarhus University, Aarhus, Denmark.

Aim: Our aim was to explore the under-researched associations between an elective Caesarean section (C-section) at early term or full term gestation and behaviour at 6-8 years of age.

Methods: We identified 1220 eligible children born by elective C-sections at Danish hospital from 2009-2011. Their mothers were randomised to elective C-sections at either 38+3 (early term) or 39+3 (full term) weeks of gestation. Read More

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http://dx.doi.org/10.1111/apa.15468DOI Listing

Breastfeeding and risk of respiratory allergies and asthma in children: Seeing things from different perspective.

Authors:
J Dimnjakovic

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Department of Medical Informatics and Biostatistics, Croatian Institute of Public Health, Zagreb, Croatia.

With great interest I read the study in Acta Paediatrica conducted by Bigman, longitudinal study examining associations between breastfeeding and respiratory allergies and types of asthma in American children. Bigman concluded "the study provided evidence that exclusive breastfeeding for the first 3 months may reduce the risk of respiratory allergies and asthma in children 6 years of age". This is an important study because it sheds light on the topic of relationship between breastfeeding and asthma since breastfeeding impact on asthma development is generally considered uncertain. Read More

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http://dx.doi.org/10.1111/apa.15470DOI Listing

Seizure-like events leading to hospital referrals in infants: a retrospective population-based study.

Acta Paediatr 2020 Jul 10. Epub 2020 Jul 10.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Aim: To identify the aetiology and outcome of seizure-like events leading to hospital referrals in infants, and to identify early predictors of epilepsy and delayed neurodevelopment.

Methods: This Norwegian population-based study focused on all children born in Sør-Trøndelag county, who were up to one year of age in 2014-2015. They were identified by diagnostic codes for seizure-like events and electroencephalography (EEG) examinations. Read More

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http://dx.doi.org/10.1111/apa.15467DOI Listing

Multiple sclerosis among first- and second-generation immigrant groups in Sweden.

Acta Neurol Scand 2020 Jul 10. Epub 2020 Jul 10.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Objectives: Risk of multiple sclerosis (MS) is low among first-generation immigrants in Sweden. We aimed to study incident MS in first- and second-generation immigrant groups.

Materials & Methods: We included adults aged 18 years and older in Sweden in first-generation (n=6,042,891) and second-generation (n=4,860,469) sub-studies. Read More

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http://dx.doi.org/10.1111/ane.13314DOI Listing

Association between utilization and quality of antenatal care with stillbirths in four tertiary hospitals in a low income urban setting.

Acta Obstet Gynecol Scand 2020 Jul 10. Epub 2020 Jul 10.

Department of Human Anatomy, University of Nairobi, Nairobi, Kenya.

Introduction: About 2.6 million stillbirths per year occur globally with 98% occurring in low and middle income countries including Kenya where an estimated 35,000 stillbirths occur annually. Most studies have focused on the direct causes of stillbirth. Read More

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http://dx.doi.org/10.1111/aogs.13956DOI Listing

Nonenzymatic amperometric sensor for hydrogen peroxide released from living cancer cells based on hierarchical NiCoO-CoNiO hybrids embedded in partially reduced graphene oxide.

Mikrochim Acta 2020 Jul 9;187(8):436. Epub 2020 Jul 9.

Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, Zhengzhou, 450001, People's Republic of China.

The synthesis of hierarchical NiCoO-CoNiO hybrids embedded in partially reduced graphene oxide (represented by NiCoO/CoNiO@pPRGO) is described. They were derived from ultrathin CoNi-based zeolitic imidazolate framework (CoNi-ZIF) nanosheets vertically grew on three-dimensional (3D) pRGO networks by pyrolysis at different temperatures (300, 600, and 900 °C) in N atmosphere. Transmission electron microscopy, X-ray diffraction, and X-ray photoemission spectroscopy measurements showed that the metal coordination centers (Co or Ni) were transferred into NiCoO spinel and CoNiO nanostructures, along with a small number of metallic states of Co and Ni. Read More

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http://dx.doi.org/10.1007/s00604-020-04419-zDOI Listing

The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body F-FDG PET/CT study.

Acta Diabetol 2020 Jul 9. Epub 2020 Jul 9.

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin 2nd Road, Shanghai, 200025, China.

Aims: Steroid diabetes mellitus (SDM) is a metabolic syndrome caused by an increase in glucocorticoids, and its pathogenesis is unclear. F-FDG PET/CT can reflect the glucose metabolism of tissues and organs under living conditions. Here, PET/CT imaging of SDM and type 2 diabetes mellitus (T2DM) rats was used to visualize changes in glucose metabolism in the main glucose metabolizing organs and investigate the pathogenesis of SDM. Read More

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http://dx.doi.org/10.1007/s00592-020-01566-wDOI Listing

Label-free chlorine and nitrogen-doped fluorescent carbon dots for target imaging of lysosomes in living cells.

Mikrochim Acta 2020 Jul 9;187(8):435. Epub 2020 Jul 9.

Key Laboratory for Advanced Materials, Shanghai Key Laboratory of Functional Materials Chemistry, Joint International Laboratory for Precision Chemistry, Frontiers Science Center for Materiobiology & Dynamic Chemistry, and School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.

Lysosomes with a single-layered membrane structure are mainly involved in the scavenging of foreign substances and play an important role in maintaining normal physiological functions of living cells. In this work, near-neutrally charged fluorescent carbon dots (CDs) were prepared with lipophilicity through a facile one-pot hydrothermal carbonization of chloranil and triethylenetetramine at 160 °C for 3 h. The as-obtained CDs are proved to have good photostability, low cost, and excellent biocompatibility. Read More

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http://dx.doi.org/10.1007/s00604-020-04412-6DOI Listing

Impact of a shift in treatment funding on a multidisciplinary sleep clinic: a cohort study.

Acta Neurol Belg 2020 Jul 9. Epub 2020 Jul 9.

ENT Department, University Hospital of Liege, Sart-Tilman B35, 4000, Liege, Belgium.

Multidisciplinary Sleep Clinics for sleep apnea have long existed, bringing together neurologists, sleep specialists, dentists, orthodontists and surgeons. In Belgium, a shift in funding for obstructive sleep apnea treatment was implemented from January 1st, 2017. Funding was allowed for moderate to severe obstructive sleep apnea and the rules shifted for treatments delivery and monitoring by authorised medical opinion. Read More

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http://dx.doi.org/10.1007/s13760-020-01419-xDOI Listing

The use of WhatsApp Messenger: an important tool in modern neurological examination.

Acta Neurol Belg 2020 Jul 9. Epub 2020 Jul 9.

Department of Neurology C05, Canisius Wilhelmina Hospital, P.O. Box 9015, 6500 GS, Nijmegen, The Netherlands.

WhatsApp Messenger is one of the most popular and still growing mobile applications worldwide in telemedicine. WhatsApp Messenger can be used as a communication tool and an adjunctive tool within telemedicine, but it is the ability or inability to use WhatsApp Messenger correctly that provides a powerful clinical neurological function tool. The easy use and the application's popularity make it extremely useful in obtaining clues in patients' neurological history. Read More

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http://dx.doi.org/10.1007/s13760-020-01435-xDOI Listing

"Plug and Play" logic gate construction based on chemically triggered fluorescence switching of gold nanoparticles conjugated with Cy3-tagged aptamer.

Mikrochim Acta 2020 Jul 9;187(8):437. Epub 2020 Jul 9.

Key Laboratory of Sensing Technology and Biomedical Instruments (Guangdong Province), School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, 510006, China.

Gold nanoparticles (AuNPs) conjugated with Cy3-tagged aptamer which can specifically recognize chloramphenicol (CAP) (referred to as AuNPs-AptCAP) are described. CAP can trigger the configuration change of CAP binding aptamer, and thus switching the fluorescence of AuNPs-AptCAP through changing the efficiency of the fluorescence resonance energy transfer (FRET) system with Cy3 as donors and AuNPs as recipients. AuNPs-AptCAP exhibits a linear range of CAP concentrations from 26. Read More

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http://dx.doi.org/10.1007/s00604-020-04421-5DOI Listing

Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress.

Acta Pharmacol Sin 2020 Jul 9. Epub 2020 Jul 9.

Department of Pharmacology, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.

Endoplasmic reticulum stress (ER stress) plays a key role in the development of cardiac hypertrophy and diabetic cardiomyopathy (DCM). Zonisamide (ZNS) was originally developed as an antiepileptic drug. Studies have shown that ZNS suppresses ER stress-induced neuronal cell damage in the experimental models of Parkinson's disease. Read More

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http://dx.doi.org/10.1038/s41401-020-0461-zDOI Listing

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation.

Acta Pharmacol Sin 2020 Jul 9. Epub 2020 Jul 9.

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

Sphingosine-1-phosphate (S1P), the backbone of most sphingolipids, activating S1P receptors (S1PRs) and the downstream G protein signaling has been implicated in chemoresistance. In this study we investigated the role of S1PR2 internalization in 5-fluorouracil (5-FU) resistance in human colorectal cancer (CRC). Clinical data of randomly selected 60 CRC specimens showed the correlation between S1PR2 internalization and increased intracellular uracil (P < 0. Read More

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http://dx.doi.org/10.1038/s41401-020-0460-0DOI Listing

KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.

Acta Pharmacol Sin 2020 Jul 9. Epub 2020 Jul 9.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

Acute renal injury (AKI) causes a long-term risk for progressing into chronic kidney disease (CKD) and interstitial fibrosis. Yes-associated protein (YAP), a key transcriptional cofactor in Hippo signaling pathway, shuttles between the cytoplasm and nucleus, which is required for the renal tubular epithelial cells repair in the acute phase of AKI. In this study we investigated the role of YAP during ischemia-reperfusion (IR)-induced AKI to CKD. Read More

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http://dx.doi.org/10.1038/s41401-020-0463-xDOI Listing

Complex I reductions in the nucleus basalis of Meynert in Lewy body dementia: the role of Lewy bodies.

Acta Neuropathol Commun 2020 Jul 9;8(1):103. Epub 2020 Jul 9.

Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, UK.

Neurons of the nucleus basalis of Meynert (nbM) are vulnerable to Lewy body formation and neuronal loss, which is thought to underlie cognitive dysfunction in Lewy body dementia (LBD). There is continued debate about whether Lewy bodies exert a neurodegenerative effect by affecting mitochondria, or whether they represent a protective mechanism. Therefore, the present study sought to determine whether the nbM is subject to mitochondrial dysfunctional in LBD and the association of Lewy body formation with such changes. Read More

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http://dx.doi.org/10.1186/s40478-020-00985-8DOI Listing

COVID-19 pandemic and its impact on service provision: A cardiology prospect.

Acta Cardiol 2020 Jul 10:1-8. Epub 2020 Jul 10.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK.

Coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the availability of cardiology services and management of cardiac conditions. Elective surgeries, outpatient appointments and cardiac imaging have been largely cancelled across the world due to the risk of infection transmission and the need for reallocation of resources to deal with the increasing number of COVID-19 patients. The impact on patients with cardiac co-morbidities during these times may be drastic. Read More

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http://dx.doi.org/10.1080/00015385.2020.1787636DOI Listing

Significance of high signal intensity in the endolymphatic duct on magnetic resonance imaging in ears with otological disorders.

Acta Otolaryngol 2020 Jul 10:1-5. Epub 2020 Jul 10.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: High signal intensity in the endolymphatic duct (ED) is occasionally observed on magnetic resonance imaging (MRI) in ears that have otological disorders.

Objective: The signal intensity (SI) in the ED on post-contrast MRI was investigated in subjects with various otological disorders, and the meaning of high SI in the ED was evaluated.

Material And Methods: 392 patients with otological disorders and 21 controls without otological symptoms underwent 3 T MRI. Read More

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http://dx.doi.org/10.1080/00016489.2020.1781927DOI Listing

Does diffusion-weighted magnetic resonance imaging have a place in the differential diagnosis of brucella sacroiliitis and seronegative spondyloarthropathy?

Acta Radiol 2020 Jul 9:284185120938370. Epub 2020 Jul 9.

Department of Physical Therapy and Rehabilitation, Harran University School of Medicine, Sanliurfa, Turkey.

Background: The aim of this study is to investigate the role of diffusion-weighted imaging (DWI) in the differential diagnosis of sacroiliitis.

Purpose: To compare the sacroiliac magnetic resonance imaging (MRI) examinations of patients with suspected active sacroiliitis with patients with acute SpA MR findings and the DWI examinations of patients with acute brucella sacroiliitis, and thereby determine whether DWI can contribute to the differential diagnosis.

Material And Methods: A total of 84 patients were included in the study and were separated into three groups: group 1 (13 women, 6 men) comprised cases with brucella positive for sacroiliitis; group 2 (17 women, 19 men) comprised cases negative for brucella but with sacroiliitis; and group 3 (16 women, 13 men) comprised cases negative for brucella and sacroiliitis. Read More

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http://dx.doi.org/10.1177/0284185120938370DOI Listing

Possible neuroprotective effects of rasagiline in Alzheimer's disease: a SPECT study.

Acta Radiol 2020 Jul 9:284185120940264. Epub 2020 Jul 9.

Department of Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: The current lack of effective treatments for Alzheimer's disease (AD) and the rapidly increasing burden of the disease highlight the urgent need to find new treatments. Despite accumulating evidence of the beneficial effects of rasagiline in neurodegenerative diseases such as Parkinson's disease, the effects of rasagiline on the brains of patients with AD have not been elucidated.

Purpose: To examine the effects of rasagiline on regional cerebral flow (rCBF) in patients with AD using single photon emission computed tomography (SPECT). Read More

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http://dx.doi.org/10.1177/0284185120940264DOI Listing

Spectroscopic characterisation and thermodynamics of the complexation of Np(V) with sulfate up to 200 °C.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 10;240:118579. Epub 2020 Jun 10.

Ruprecht Karls Universität Heidelberg, Physikalisch-Chemisches Institut, Im Neuenheimer Feld 253, D-69120 Heidelberg, Germany; Karlsruher Institut für Technologie (KIT), Institut für Nukleare Entsorgung (INE), D-76344 Eggenstein-Leopoldshafen, Germany.

In the present work the complexation of Np(V) with sulfate in aqueous solution is studied in a temperature range up to 200 °C by absorption spectroscopy. For this purpose, a new spectroscopic setup is implemented and tested for its suitability for Vis/NIR absorption spectroscopy at elevated temperatures. The complexation of Np(V) with sulfate is studied as a function of the total ligand concentration at various temperatures (T = 25-200 °C) and ionic strengths (I(NaClO) = 1. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118579DOI Listing

The use of green spectroscopy with multivariate calibration models for simultaneous analysis of ternary drug mixture in combined oral antidiabetic pill.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 23;241:118638. Epub 2020 Jun 23.

Pharmaceutical Analysis Department, Faculty of Pharmacy, Menoufia University, Egypt. Electronic address:

In this work, different chemometric calibration models were developed and validated for the purpose of determining of ternary mixture of oral antidiabetic drugs; vildagliptin (VDG), saxagliptin (SAX) and sitagliptin phosphate (STG). The used models were Partial least squares (PLS) and Artificial Neural Networks (ANN). However, on these various models the impact of genetic algorithm (GA) as a form of variable selection was also investigated. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118638DOI Listing

Colorimetric detection of cholesterol based on peroxidase mimetic activity of GoldMag nanocomposites.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 1;241:118675. Epub 2020 Jul 1.

College of Food Engineering, Harbin University of Commerce, Harbin 150076, People's Republic of China.

Herein, Gold and magnetic particles (GoldMag), an enzyme mimetic of horseradish peroxidase (HRP), have been designed to construct a colorimetric sensor for cholesterol (Cho). The well-dispersed GoldMag was successfully prepared by green reduction using a self-assembly method based on the surface amino groups, and characterized by Fourier transform infrared (FTIR), X-Ray Photoelectron Spectroscopic (XPS) techniques. In the presence of HO, the resulting nanocomposites possessed enhanced intrinsic peroxidase-like activity and could catalytically oxidize 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) to produce a green colored product, which could be observed apparently by the naked eye. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118675DOI Listing

Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.

Biochim Biophys Acta Gen Subj 2020 Jul 6:129678. Epub 2020 Jul 6.

University of York, Department of Biology, York YO10 5DD, United Kingdom.

Background: The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein of the hnRNP H/F family, which has been implicated in erythropoiesis, regulation of the redox homeostasis, embryonic brain development, mitochondrial function and cellular senescence. The molecular basis for GRSF1-RNA interaction has extensively been studied in the past but for the time being GRSF1 binding proteins have not been identified.

Methods: To search for GRSF1 binding proteins we first employed the yeast two-hybrid system and screened a cDNA library of human fetal brain for potential GRSF1 binding proteins. Read More

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http://dx.doi.org/10.1016/j.bbagen.2020.129678DOI Listing

Analysis of Hashimoto's thyroiditis on fine needle aspiration samples by MALDI-Imaging.

Biochim Biophys Acta Proteins Proteom 2020 Jul 6:140481. Epub 2020 Jul 6.

Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, ASST, Monza, Italy. Electronic address:

Matrix-Assisted Laser Desorption/Ionization (MALDI)- Mass Spectrometry imaging (MSI) has been applied in various diseases aimed to biomarkers discovery. In this study diagnosis and prognosis of Hashimoto Thyroiditis (HT) in cytopathology by MALDI-MSI has been investigated. Specimens from a routine series of subjects who underwent UltraSound-guided thyroid Fine Needle Aspirations (FNAs) were used. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140481DOI Listing

Interstitial Fluid-Solid Interaction within Aneurysmal and Non-pathological Human Ascending Aortic Tissue under Translational Sinusoidal Shear Deformation.

Acta Biomater 2020 Jul 6. Epub 2020 Jul 6.

Department of Mechanical Engineering University of Maryland, College Park, MD 20742, USA; R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD USA.

The interaction shear force between internal interstitial fluid motion and the solid circumferential-longitudinal medial lamellae helps generate the shear stress involved in dissection of human ascending aorta aneurysmal or non-pathologic tissue. Frequency analysis parameters from the total shear stress versus time response to translational 1 Hz sinusoidal shear deformation over 50 cycles measure the interaction with respect to the three factors: tissue type, sinusoidal deformation amplitude and direction of the shear deformation. Significant 1, 3, and 5 Hz components exist in this order of descending magnitude for shear deformation amplitudes of either 25% or 50% of the specimen length. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.045DOI Listing

Stem Cell Derived Extracellular Vesicles for Vascular Elastic Matrix Regenerative Repair.

Acta Biomater 2020 Jul 6. Epub 2020 Jul 6.

Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. Electronic address:

Abdominal aortic aneurysms (AAA) are localized expansions of the abdominal aorta that develop due to chronic proteolytic disruption of the structural extracellular matrix (ECM) components (elastin and collagen) within the aorta wall. Major limitations in arresting or reversing AAAs lie in naturally poor and aberrant regeneration and repair of elastic matrix structures in the aorta wall. Bone marrow derived mesenchymal stem cells (BM-MSCs) have emerged as a promising regenerative tool and their therapeutic effects are also known to be effected through their paracrine secretions. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.07.002DOI Listing
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