Acta Biomater 2022 Aug 7. Epub 2022 Aug 7.
Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA; Utah Center for Nanomedicine, University of Utah, Salt Lake City, Utah, USA; TheraTarget, Inc., Salt Lake City, Utah, USA; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA. Electronic address:
Cerebral aneurysms (CA), an abnormal bulge in the arteries that supply blood to the brain, are prone to rupture and can cause hemorrhagic stroke. Physicians can treat CA by blocking blood flow to the aneurysmal sac via clipping of the aneurysm neck via open procedure, or endovascular occlusion of the aneurysm with embolic materials to promote thrombus formation to prevent further inflow of blood into the aneurysm. Endovascular treatment options for CA still have significant limitations in terms of safety, usability in coagulopathic patients, and risks of device migration. Read More