705,332 results match your criteria Acta Physica Polonica B[Journal]

On strain-based rupture criterion for ascending aortic aneurysm: the role of fiber waviness.

Xuehuan He Jia Lu

Acta Biomater 2022 Jun 24. Epub 2022 Jun 24.

Department of Mechanical Engineering, and Iowa Technology Institute The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

We propose a new approach for constructing strain-based rupture criterion for ascending thoracic aortic aneurysm. The rupture metric is formulated using an effective strain, which is a measure of net strain that the collagen bundles experience after fiber uncrimping. The effective strain is a function of the total strain and the waviness properties of the collagen fibers. Read More

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Genomic analysis of 9 infants with hypermethioninemia by whole-exome sequencing among in Henan, China.

Clin Chim Acta 2022 Jun 24. Epub 2022 Jun 24.

Department of Henan Newborn Screening Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450054, China. Electronic address:

Background: Hypermethioninemia is an inborn error of metabolism with elevated plasma methionine (Met) caused by methionine adenosyltransferase deficiency. Methionine adenosyltransferase (MAT) I/III deficiency is the most common cause of hypermethioninemia. Except for increased blood Met, most patients have no symptoms, but a small number have nervous system complications, including cognitive impairment and mental retardation. Read More

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High Prevalence of Cervical High-Grade Lesions and High-Risk Human Papillomavirus Infections in Women Living with HIV: A Case for Prioritizing Cervical Screening in This Vulnerable Group.

Acta Cytol 2022 Jun 27:1-11. Epub 2022 Jun 27.

Division of Cytopathology, ICMR-National Institute of Cancer Prevention and Research, Noida, India.

Introduction: Women living with HIV (WLHIV) are at an increased risk of developing cervical precancerous lesions and cervical human papillomavirus (HPV) infection. This study aimed at evaluating the prevalence of cervical lesions and high-risk HPV (HR-HPV) infection in WLHIV in comparison to the HIV-negative women undergoing opportunistic screening. In addition, these findings among WLHIV were correlated with the clinic-demographic factors. Read More

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L-histidine functionalized ZiF-8 with aggregation-induced emission for detection of tetracycline.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 22;280:121546. Epub 2022 Jun 22.

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China; YuZhang Normal University, Nanchang 330013, PR China. Electronic address:

In this study, we constructed zinc based metal-organic framework functionalized by L-histidine ([email protected]). The [email protected] had high porosity, large surface area, abundant carboxyl and amino group, which has been found to greatly enhance the aggregation-induced emission (AIE) of tetracycline (TC). After the [email protected] enrichment with TC, the TC exhibited strong fluorescence emission peak at 565 nm based on AIE. Read More

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Eco-friendly spectrophotometric evaluation of triple-combination therapies in the treatment strategy of patients suffering from hypertension during coronavirus pandemic - Spectralprint recognition study.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 18;280:121523. Epub 2022 Jun 18.

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt, 11835 Cairo, Egypt.

Recent studies have reported that using certain antihypertensive therapies such as angiotensin II receptor blockers (ARBs) and calcium channel blocker (CCBs) is associated with reduction of fatal outcomes and improving clinical characteristics of patients suffering from hypertension during coronavirus pandemic. Thus, in the current work an effective, innovative and eco-friendly spectrophotometric manner namely, parent spectrum extraction (PSE)was established for evaluation of recommended triple antihypertensive combination therapies incorporate valsartan (VAL) as ARBs, amlodipine besylate as CCBs (AML) and hydrochlorothiazide (HCT)as diuretic into single-pill in challengeable ratio. PSE manner composed of two complementary steps, auxiliary resolution coupled with data analysis resolution(DAR)and it is characterized by resolving the spectral bands of the drugs and extraction of their discrete parent spectra (D); accordingly, enabling determination of each analyte at its λ. Read More

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Computational investigation on the geometry and electronic structures and absorption spectra of metal-porphyrin-oligo- phenyleneethynylenes-[60] fullerene triads.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 23;280:121488. Epub 2022 Jun 23.

Department of Chemistry, Faculty of Science Hamedan Branch, Islamic Azad University, Hamedan, Iran.

In this work, we focus our attention on the influence of 2nd-row transition metals on the structural geometries, electronic structures, and absorption characteristics of porphyrin linked with the C fullerene with oligo-p-phenyleneethynylenes (MP-C-oligo-PPEs) compounds. The DFT/B3PW91-D3 and CAM-B3LYP-D3/6-31G (d) calculations revealed that various metals embedded within the porphyrin moiety give different bridge conformations and different HOMO-LUMO energy levels. We calculate the UV-Vis spectra and absorption parameters using the time-dependent ZINDO/S approach. Read More

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A simple lysosome-targeted fluorescent probe based on flavonoid for detection of cysteine in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 23;280:121552. Epub 2022 Jun 23.

Key Laboratory of Occupational Environment and Health, Guangzhou Twelfth People's Hospital, No. 1 Tianqiang Road, Tianhe District, Guangzhou 510620, Guangdong, PR China. Electronic address:

Cysteine (Cys) is one of the most important biothiols that plays a crucial role in many physiological and pathological processes, and therefore it is of great importance to detect and analyze Cys in subcellular environments, such as in lysosomes. However, only a few fluorescent probes were reported to be capable of detecting Cys in lysosomes selectively. In this wok, we designed and developed a simple, accessible flavone-based fluorescent probe LFA for detecting Cys in lysosomes. Read More

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Learning motivation tendencies among preschoolers: Impact of executive functions and gender differences.

Acta Psychol (Amst) 2022 Jun 24;228:103647. Epub 2022 Jun 24.

Department of Teacher Education, University of Turku, Turku, Finland.

The current study aimed to validate the Russian version of the Child Behaviour Motivation Scale (CBeMO), examine gender differences in motivational tendencies, and explore the impact of executive functions on learning motivation tendencies among children. The sample consisted of 434 typically developing 5-6 years old children. The confirmatory factor analysis showed that according to the evaluation criteria, the model is poorly fitted to the data. Read More

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microRNA-146a mediates distraction osteogenesis via bone mesenchymal stem cell inflammatory response.

Acta Histochem 2022 Jun 24;124(6):151913. Epub 2022 Jun 24.

Departement of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University, Nanning 530021, People's Republic of China; Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment, Guangxi Clinical Research Center for Craniofacial Deformity, Nanning 530021, People's Republic of China. Electronic address:

Distraction osteogenesis (DO) is a widely used surgical technique to repair bone defects, partly owing to its high efficiency in inducing osteogenesis; however, the process of osteogenesis is complex, and the precise mechanism is still unclear. Among the factors identified for an effective DO procedure, well-controlled inflammation is essential. We aimed to explore how microRNA(miR)-146a, a negative regulator of inflammation, influences osteogenesis in DO. Read More

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The Compass of Biomedicine.

Acta Physiol (Oxf) 2022 Jun 27:e13856. Epub 2022 Jun 27.

Institute of Translational Physiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

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Predictors of intraoperative intracranial aneurysm rupture in patients with subarachnoid hemorrhage: a retrospective analysis.

Acta Neurol Belg 2022 Jun 27. Epub 2022 Jun 27.

Department of Neurosurgery and Neurotraumatology, Jagiellonian University Medical College, Kraków, Poland.

Purpose: Intraoperative cerebral aneurysm rupture (IOR) is a common phenomenon with a frequency of around 19%. Research regarding IOR lacks an analysis of its predictors.

Methods: We retrospectively examined all saccular aneurysms, in 198 patients with subarachnoid hemorrhage, surgically treated from 2013 to 2019. Read More

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Iatrogenic post-surgical tension pneumosyrinx-a first reported case.

Acta Neurochir (Wien) 2022 Jun 27. Epub 2022 Jun 27.

Department of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.

We describe the first ever-reported occurrence of a post-operative tension pneumosyrinx occurring after a resection of an intradural intramedullary spinal tumour in a 40-year-old patient. Post-operatively, he developed sudden onset paraplegia and imaging revealed a tension pneumosyrinx which was subsequently surgically decompressed. He made a gradual neurological recovery. Read More

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The Alzheimer's disease GWAS risk alleles in the ABCA7 promoter and 5' region reduce ABCA7 expression.

Acta Neuropathol 2022 Jun 27. Epub 2022 Jun 27.

Alzheimer's Center at Temple, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

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A High Programmed Cell Death Protein 1 Hormone Receptor Score on Skin Biopsy is Associated with Sézary Syndrome Diagnosis: A Study of 91 Patients with Erythroderma.

Acta Derm Venereol 2022 Jun 27. Epub 2022 Jun 27.

Dermatology Department, CHU de Bordeaux, Bordeaux, France.

Erythroderma is challenging to diagnose. The aim of this single-centre retrospective study was to identify factors that can be used to improve the diagnosis of erythroderma. Among 91 patients with erythroderma, 21 were diagnosed with eczema, 17 with psoriasis, 20 with drug-induced erythroderma, 13 with erythrodermic mycosis fungoides and 20 with Sézary syndrome. Read More

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Ability to Predict Melanoma Within 5 Years Using Registry Data and a Convolutional Neural Network: A Proof of Concept Study.

Acta Derm Venereol 2022 Jun 27. Epub 2022 Jun 27.

Research relating to machine learning algorithms, including convolutional neural networks, has increased during the past 5 years. The aim of this pilot study was to investigate how accurately a convolutional neural network, trained on Swedish registry data, could perform in predicting cutaneous invasive and in situ melanoma (CMM) within 5 years. A cohort of 1,208,393 individuals was used. Read More

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A nationwide study on characteristics and outcome of cancer patients with sepsis requiring intensive care.

Acta Oncol 2022 Jun 26:1-9. Epub 2022 Jun 26.

Department of Anaesthesia and Intensive Care, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.

Background: Sepsis is the leading cause of admission to the intensive care unit (ICU) for cancer patients and survival rates have historically been low. The aims of this nationwide cohort study were to describe the characteristics and outcomes of cancer patients admitted to the ICU with sepsis compared with other sepsis patients requiring ICU admission.

Material And Methods: This was a retrospective, observational study. Read More

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Debriefing or Feedback: Exploring the Impact of Two Post-Scenario Discussion Methods in the Acquisition and Retention of Non-Technical Skills.

Acta Med Port 2022 Jun 27. Epub 2022 Jun 27.

Biomedical Simulation Center. Faculty of Medicine. University of Porto. Department of Surgery and Physiology. Faculty of Medicine. University of Porto. CUF Porto Hospital. Porto. Portugal.

Introduction: There is a paucity of quantitative studies objectively comparing debriefing and feedback as methods for post-scenario discussion and its impact on healthcare teams' acquisition and retention of non-technical skills. The main purpose of this study is to provide some insight on this research question, using a sample of medical students. A secondary objective explores students' opinion and preference on the post-scenario discussion. Read More

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The International Hip Dysplasia Institute (IHDI) classification is more informative than the Tönnis classification.

Acta Radiol 2022 Jun 26:2841851221110447. Epub 2022 Jun 26.

Department of Orthopaedics, Lund University, 59565Skåne University Hospital, Malmo, Sweden.

Background: A new, supposedly more reproducible radiographic classification, set to replace the Tönnis classification of hip dislocations, was proposed in 2015: the International Hip Dysplasia Institute (IHDI) classification.

Purpose: To compare the IHDI classification with the Tönnis classification when evaluating the severity of hip dislocations as well as their respective inter- and intra-observer reliability.

Material And Methods: Since January 2000, Swedish-born children with a hip dislocation were prospectively registered. Read More

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ALZT-OP1: An experimental combination regimen for the treatment of Alzheimer's Disease.

Expert Opin Investig Drugs 2022 Jun 25. Epub 2022 Jun 25.

Unit of Research Methodology and Data Sciences for Population Health, National Institute of Gastroenterology and Research Hospital IRCCS "S. De Bellis" Castellana Grotte, Bari, Italy.

Introduction: For Alzheimer's disease (AD) treatment, US FDA granted accelerated approval for aducanumab due to its amyloid-β (Aβ)-lowering effects, notwithstanding the reported poor correlation between amyloid plaque reduction and clinical change for this drug. The diversification of drug targets appears to be the future of the AD field and from this perspective, drugs modulating microglia dysfunction and combination treatment regimens offer some promise.

Areas Covered: The aim of the present article was to provide a comprehensive review of ALZT-OP1 (cromolyn sodium plus ibuprofen), an experimental combination treatment regimen for AD, discussing their mechanisms of action targeting Aβ and neuroinflammation, examining the role of microglia in AD and offering our own insights on the role of present and alternative approaches directed toward neuroinflammation. Read More

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Carotid body responses to O and CO in hypoxia-tolerant naked mole rats.

Acta Physiol (Oxf) 2022 Jun 27:e13851. Epub 2022 Jun 27.

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois, USA.

Aim: Naked mole rats (NMRs) exhibit blunted hypoxic (HVR) and hypercapnic ventilatory responses (HCVR). The mechanism(s) underlying these responses are largely unknown. We hypothesized that attenuated carotid body (CB) sensitivity to hypoxia and hypercapnia contributes to the near absence of ventilatory responses to hypoxia and CO in NMRs. Read More

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Whole-body magnetic resonance imaging findings and patterns of chronic nonbacterial osteomyelitis in a series of Greek pediatric patients.

Acta Radiol Open 2022 Jun 22;11(6):20584601221106701. Epub 2022 Jun 22.

Department of Radiology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.

Background: Chronic nonbacterial osteomyelitis (CNO) is a pediatric autoinflammatory disorder presenting with sterile inflammatory bone lesions. Whole-body MRI (WBMRI) has most recently emerged for disease assessment, but data are limited.

Purpose: The purpose is to evaluate the imaging findings and patterns of CNO on WBMRI in a series of Greek pediatric patients. Read More

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Comparison between fully resolved and time-averaged simulations of particle cloud dispersion produced by a violent expiratory event.

Acta Mech Sin 2022 25;38(8):721489. Epub 2022 Apr 25.

Departament d'Enginyeria Mecánica, Universitat Rovira i Virgili, Spain, Av. Països Catalans, Tarragona 26, 43007 Spain.

In this work we compare the DNS results (Fabregat et al. 2021, Fabregat et al. 2021) for a mild cough already reported in the literarure with those obtained with a compressible URANS equations with a turbulence model. Read More

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Adaptation to DNA Damage, an Asymptotic Approach for a Cooperative Non-local System.

Acta Appl Math 2022 21;180(1). Epub 2022 Jun 21.

Mathematical Institute, University of Oxford, OX2 6GG Oxford, UK.

Following previous works about integro-differential equations of parabolic type modelling the Darwinian evolution of a population, we study a two-population system in the cooperative case. First, we provide a theoretical study of the limit of rare mutations and we prove that the limit is described by a constrained Hamilton-Jacobi equation. This equation is given by an eigenvalue of a matrix which accounts for the diffusion parameters and the coefficients of the system. Read More

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Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years.

Acta Pharm Sin B 2022 Jun 11;12(6):2790-2807. Epub 2022 Jan 11.

Institute of Pharmaceutical Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.

Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs). Prostaglandins are a class of lipid compounds that mediate acute and chronic inflammation. Read More

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Development and clinical advancement of small molecules for expansion of hematopoietic stem cell.

Acta Pharm Sin B 2022 Jun 17;12(6):2808-2831. Epub 2021 Dec 17.

State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its widespread use. Read More

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NAMPT-targeting PROTAC promotes antitumor immunity suppressing myeloid-derived suppressor cell expansion.

Acta Pharm Sin B 2022 Jun 31;12(6):2859-2868. Epub 2021 Dec 31.

School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Nicotinamide phosphoribosyl transferase (NAMPT) is considered as a promising target for cancer therapy given its critical engagement in cancer metabolism and inflammation. However, therapeutic benefit of NAMPT enzymatic inhibitors appears very limited, likely due to the failure to intervene non-enzymatic functions of NAMPT. Herein, we show that NAMPT dampens antitumor immunity by promoting the expansion of tumor infiltrating myeloid derived suppressive cells (MDSCs) a mechanism independent of its enzymatic activity. Read More

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Liposome-based multifunctional nanoplatform as effective therapeutics for the treatment of retinoblastoma.

Acta Pharm Sin B 2022 Jun 22;12(6):2731-2739. Epub 2021 Oct 22.

Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.

Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Read More

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Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death.

Acta Pharm Sin B 2022 Jun 14;12(6):2740-2750. Epub 2021 Jul 14.

Key Laboratory of Bioactive Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Collaborative Innovation Center of Chemical Science and Engineering, National Institute of Functional Materials, Nankai University, Tianjin 300071, China.

Immunogenic cell death (ICD) plays a major role in cancer immunotherapy by stimulating specific T cell responses and restoring the antitumor immune system. However, effective type II ICD inducers without biotoxicity are still very limited. Herein, a tentative drug- or photosensitizer-free strategy was developed by employing enzymatic self-assembly of the peptide F-pY-T to induce mitochondrial oxidative stress in cancer cells. Read More

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Erratum: Author correction to "A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease" [Acta Pharmaceutica Sinica B 12, (2021) 4032-4044].

Acta Pharm Sin B 2022 Jun 15;12(6):2965-2967. Epub 2022 Apr 15.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

[This corrects the article DOI: 10.1016/j.apsb. Read More

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