650,007 results match your criteria Acta Pharmacologica Sinica[Journal]


Unplanned extubations in general intensive care unit: A nine-year retrospective analysis.

Acta Biomed 2018 Dec 7;89(7-S):25-31. Epub 2018 Dec 7.

ASST Monza, Ospedale San Gerardo - università degli Studi di Milano-Bicocca.

Background And Aim: Unplanned extubation (UE) in Intensive Care Units (ICU) is an indicator of quality and safety of care. UEs are classified in: accidental extubations, if involuntarily caused during nursing care or medical procedures; self-extubation, if determined by the patient him/herself.  In scientific literature, the cumulative incidence of UEs varies from 0. Read More

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December 2018
3 Reads

Factors associated with and impact of burnout in nursing and residential home care workers for the elderly.

Acta Biomed 2018 Dec 7;89(7-S):60-69. Epub 2018 Dec 7.

Department of Psychology, Swansea University.

Background And Aim Of The Work: Numbers of elderly people worldwide continue to grow. Increasingly these individuals require nursing and residential care to meet their needs. Nursing is an occupation associated with burnout amongst its workforce, associated with increases of emotional exhaustion, depersonalisation and decreases in personal accomplishment. Read More

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December 2018

A first contribution to the validation of the Italian version of the Behavioral Pain Scale in sedated, intubated, and mechanically ventilated paediatric patients.

Acta Biomed 2018 Dec 7;89(7-S):19-24. Epub 2018 Dec 7.

Department of Medicine and Surgery, Parma University, Italy.

Background And Aim Of The Work: Numerous negative outcomes of inadequate pain management among children have been cited in the literature. Inadequate pain management may be particularly detrimental to children and adolescents facing life-threatening injury or illness on a Paediatric Intensive Care Unit (PICU). It is therefore absolutely necessary that professionals utilize effective and efficient tools in order to evaluate a person's sensations of pain in the most objective way possible. Read More

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December 2018

Application of palliative care in demented patients: the caregivers' point of view.

Acta Biomed 2018 Dec 7;89(7-S):78-88. Epub 2018 Dec 7.

Università di Parma.

Background: The 38/2010 law has widened the supply of palliative care for patients with chronic and degenerative illness. Dementia is a chronic and debilitating illness and it requires specific, complex and constant assistance, involving the health professionals' community and family, and should also benefit from palliative care. But what do the caregivers of these patients think about it?

Aim: To explore the point of view of caregivers accompanying dementia patients regarding palliative care and the accompaniment of the medical team. Read More

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December 2018

Incidence and type of health care associated injuries among nursing students: an experience in northern Italy.

Acta Biomed 2018 Dec 7;89(7-S):41-49. Epub 2018 Dec 7.

Corso di Laurea in Infermieristica Università di Bologna - Faenza.

Background And Aim Of The Study: Nursing students are at high risk of injury while on clinical placement. The incidence of injury is three times higher in comparison to other healthcare workers, with a prevalence ranging from 25% up to 33,2%. Lack of knowledge and of experience in delivering nursing care, anxiety and unfamiliarity with the clinical environment all represent risk factors for injury. Read More

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December 2018

Foreword.

Acta Biomed 2018 Dec 7;89(7-S). Epub 2018 Dec 7.

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Foreword. Read More

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December 2018

Mapping Caregivers' Health Assets. A self-care project using Salutogenesis and Mindfulness.

Acta Biomed 2018 Dec 7;89(7-S):70-77. Epub 2018 Dec 7.

ADEIT University-Business Foundation, University of Valencia (Spain).

Background: Thousands of caregivers around the world take care of impaired people, with negative repercussions on their physical, psychological, social and economic resources. The need to promote caregivers' wellbeing is internationally recognized, thus reducing health inequalities. Mindfulness is a powerful tool, directly related to the reduction of stress, able to increase skills and attitudes promoting well-being. Read More

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December 2018

The efficacy of interprofessional simulation in improving collaborative attitude between nursing students and residents in medicine. A study protocol for a randomised controlled trial.

Acta Biomed 2018 Dec 7;89(7-S):32-40. Epub 2018 Dec 7.

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Background: Effective collaboration among health professionals is an essential component to ensure quality of care. Many adverse events experienced by patients are attributed to misunderstanding or poor communication among members of the interprofessional team. Interprofessional simulation is a learning strategy used to improve collaboration and facilitate communication between medical and nursing students. Read More

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December 2018

"I would like to tatoo the illness on my arm". The Integrated Personalized Nursing Diagnosis (IPND).

Acta Biomed 2018 Dec 7;89(7-S):50-59. Epub 2018 Dec 7.

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Background And Aim: The nursing diagnosis can based on two different approaches: the standard diagnosis, searching for regularities that can fall within pre-existing categories identified by the nurse, as the expert of the disease; the narrative diagnosis, based on personal meaning attributed to the illness, of which only the patient is the expert. The aim of this work is to underline the usefulness of integration between standard diagnosis and narrative diagnosis, through the Integrated Personalized Nursing Diagnosis (IPND).

Methods: A 31 years old man, suffering from leukaemia, is welcomed at an Italian Oncological Day Hospital, by a nurse trained in the IPND approach. Read More

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December 2018

Patient-ventilator asynchronies: types, outcomes and nursing detection skills.

Acta Biomed 2018 Dec 7;89(7-S):6-18. Epub 2018 Dec 7.

Fondazione Poliambulanza Hospital, Brescia (Italy).

Background: Mechanical ventilation is often employed as partial ventilatory support where both the patient and the ventilator work together. The ventilator settings should be adjusted to maintain a harmonious patient-ventilator interaction. However, this balance is often altered by many factors able to generate a patient ventilator asynchrony (PVA). Read More

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December 2018

Preface to Emergence of Complex Behavior in Biomembranes.

Authors:
Marjorie L Longo

Biochim Biophys Acta Biomembr 2018 Oct 12;1860(10):1955-1956. Epub 2018 Sep 12.

Department of Chemical Engineering, University of California Davis, Davis, California, 95616, United States.

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October 2018

Practice variations in salivary gland imaging and utility of virtual unenhanced dual energy CT images for the detection of major salivary gland stones.

Acta Radiol 2018 Dec 12:284185118817906. Epub 2018 Dec 12.

1 Department of Radiology, Jewish General Hospital & McGill University, Montreal, QC, Canada.

Background: There are variations in computed tomography (CT) protocols used for evaluating sialolithiasis, with some protocols including acquisitions before and after IV contrast administration. Dual-energy CT (DECT) can be used to generate virtual unenhanced (VUE) images, potentially precluding the need for an uninfused scan.

Purpose: In this study, we performed a survey in order to assess variations in the imaging approach for sialolithiasis and evaluated the accuracy of DECT VUE images for the detection of salivary stones. Read More

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December 2018

Subarachnoid extension of lobar hemorrhage on acute/subacute MRI is associated with cerebral amyloid angiopathy criteria.

Acta Neurol Belg 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.

Subarachnoid hemorrhage extension (SAHE) in the acute phase of cerebral amyloid angiopathy (CAA)-related lobar hemorrhage (LH) assessed by CT is very frequent. Recently, SAHE, together with finger-like projections on CT and ApoE4, has been used in a prediction model for histopathologically proven CAA showing excellent discrimination. Our aim was to analyze SAHE on MRI in the acute and subacute phase of LH in patients with and without associated hemorrhagic features supportive of CAA (i. Read More

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December 2018

Colorimetric determination of glucose in solution and via the use of a paper strip by exploiting the peroxidase and oxidase mimicking activity of bimetallic Cu-Pd nanoparticles deposited on reduced graphene oxide, graphitic carbon nitride, or MoS nanosheets.

Mikrochim Acta 2018 Dec 11;186(1):13. Epub 2018 Dec 11.

Advanced Materials Group, Materials Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, 785006, India.

This work describes the preparation of bimetallic Cu-Pd nanoparticles (NPs) on supports like reduced graphene oxide (rGO), graphitic carbon nitride (g-CN) and MoS sheets with a size of <10 nm. rGO is found to be the best support for synthesizing Cu-Pd NPs with controlled shape, size and oxidation state. The Cu-Pd/rGO nanocomposite also demonstrated the best peroxidase and oxidase mimicking activity compared to Cu-Pd/g-CN and Cu-Pd/MoS nanocomposites. Read More

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December 2018
1 Read

A summer wave of vertebral fractures: the "deck-slap" injury.

Acta Neurochir (Wien) 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurosurgery, Sainte-Anne Military Hospital, BP 600, 83800, Toulon Cedex 09, France.

Background: Every summer, several patients who suffer from vertebral fractures are hospitalized at the Sainte-Anne Military Hospital after going on a boat trip around the French Riviera. The uniqueness of these fractures lies in their mechanism of injury, called the "deck-slap" injury. The aim of this study is to describe the characteristics of the "deck-slap" injury. Read More

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December 2018
1 Read

A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis.

Acta Diabetol 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Mineralized Tissues, Center for Translational and Clinical Research, School of Medicine, University of Zagreb, Salata 11, Zagreb, Croatia.

Aims: Bone morphogenetic proteins (BMPs) are involved in the development and homeostasis of multiple organs and tissues. There has been a significant focus on understanding the role of BMPs in pancreatic β-cell dysfunction associated with type 2 diabetes (T2D). Our objective was to investigate the relationship between BMP6 and glucose homeostasis. Read More

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December 2018
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The reproducibility of assessment of white spot lesions adjacent to orthodontic brackets, with a quantitative light induced fluorescence digital camera at different rotations of teeth - an in vitro study.

BMC Oral Health 2018 Dec 11;18(1):209. Epub 2018 Dec 11.

Department of preventive dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081, LA, Amsterdam, The Netherlands.

Background: A quantitative light-induced fluorescence digital (QLF-D) camera is able to assess demineralizations adjacent to orthodontic brackets. Rotations of teeth during and the presence of the orthodontic appliances may influence the longitudinal follow-up of such lesions over time.

Methods: Brackets were bonded on extracted teeth: 54 incisors and 31 canines. Read More

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December 2018

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease.

Acta Neuropathol Commun 2018 Dec 11;6(1):136. Epub 2018 Dec 11.

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, Strasbourg, France.

Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer's disease (AD), but the mechanisms involved remain unclear. Because growing evidence suggested that the stimulation of proteases digesting Aβ, especially the endopeptidase neprilysin (NEP) may be effective for AD therapy/prevention, we explored the involvement of serotonin precursors and derivatives in NEP regulation. We found that 5-hydroxyindolacetic acid (5-HIAA), the final metabolite of serotonin, considered until now as a dead-end and inactive product of serotonin catabolism, significantly reduces brain Aβ in the transgenic APPSWE mouse model for AD-related Aβ pathology and in the phosphoramidon-induced cerebral NEP inhibition mouse model. Read More

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December 2018

Intramedullary spinal tumor-like lesions.

Acta Radiol 2018 Dec 11:284185118809540. Epub 2018 Dec 11.

4 Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.

The development of magnetic resonance imaging (MRI) has led to an increasingly frequent detection of changes in the spinal cord. The most common intramedullary lesions are: demyelinating; vascular; inflammatory; infectious; and congenital, largely called tumor-like lesions. Spinal cord tumors are relatively rare, as compared with brain tumors. Read More

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December 2018

Hemophagocytic Lymphohistiocytosis during the Postpartum Stage of Pregnancy: A Report of Eight Cases.

Acta Haematol 2018 Dec 7;141(1):55-60. Epub 2018 Dec 7.

Haemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome that can be classified as either primary or secondary. Secondary HLH can be triggered by a variety of diseases. Pregnancy-related HLH has already been observed clinically. Read More

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December 2018

Postpartum Hemophagocytic Lymphohystiocytosis: A New Entity Is Born.

Acta Haematol 2018 Dec 7;141(1):61-62. Epub 2018 Dec 7.

Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel.

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December 2018

Formation mechanisms of Caprolactam-tetraalkyl ammonium halide deep eutectic and its hydrate.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 5;211:189-194. Epub 2018 Dec 5.

School of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei, 050018, China; Pollution prevention biotechnology laboratory of Hebei Province, 050018, China. Electronic address:

Deep eutectic solvents (DES) are generally composed of two or three cheap and safe components that are associated with each other via hydrogen bonds. The formation Caprolactam (CPL)-tetraalkyl ammonium halide (TAAX) DES and its hydrate were investigated using React IR. TAAX was introduced to CPL in the molten state at 353. Read More

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December 2018

A multifunctional sensor for selective and sensitive detection of vitamin B12 and tartrazine by Förster resonance energy transfer.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 4;211:178-188. Epub 2018 Dec 4.

Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong 637002, China; Institute of Applied Chemistry, China West Normal University, Nanchong 637002, China. Electronic address:

We used thiamine nitrate (TN) as single material to fabricate nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs) with a quantum yield of 10.4% through one-pot hydrothermal method, and its properties were characterized by TEM, XPS, FTIR, fluorescence (FL) and UV-vis spectrophotometer, respectively. The fluorescence of N,S-CQDs was effectively quenched in the presence of vitamin B12 (VB12)/tartrazine due to Förster resonance energy transfer (FRET). Read More

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December 2018
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Measurements and correlations in solution-state for charge transfer products caused from the 1:2 complexation of TCNE acceptor with several important drugs.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 5;211:166-177. Epub 2018 Dec 5.

Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, 21974 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

In our previous work, we highlighted the thermodynamic and spectroscopic characteristics of the 1:1 charge transfer (CT) complexation of TCNE acceptor with various medically important drugs. Continuing that work, we further examine drugs that react with the TCNE acceptor via a 1:2 interaction. The examined drugs are atenolol, quinidine, cimetidine, reserpine, and levofloxacin. Read More

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December 2018

The synthesis of Ag-coated tetrapod gold nanostars and the improvement of surface-enhanced Raman scattering.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 4;211:154-165. Epub 2018 Dec 4.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address:

In this work, the novel tetrapod gold nanostars with four specific numbers of sharp tips were synthesized with good uniformity, high yield and chemical stability. The size of tetrapod gold nanostars has been increased effectively by increasing the amount of HAuCl or DEA added to the reaction solution, and the corresponding in-plane localized surface plasmon resonance (LSPR) band can shift from 700 to 1100 nm. In order to combine the advantages of different metals, the Ag-coated tetrapod gold nanostars were prepared with different Ag coating thicknesses by increasing the volume of AgNO. Read More

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December 2018

Topological design, permeability and mechanical behavior of additively manufactured functionally graded porous metallic biomaterials.

Acta Biomater 2018 Dec 8. Epub 2018 Dec 8.

Department of Biomechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.

Recent advances in additive manufacturing (AM) have enabled the fabrication of functionally graded porous biomaterials (FGPBs) for application as orthopedic implants and bone substitutes. Here, we present a step-wise topological design of FGPB based on diamond unit cells to mimic the structure of the femoral diaphysis. The FGPB was manufactured from Ti-6Al-4V powder using the selective laser melting (SLM) technique. Read More

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December 2018
2 Reads

Development of an in house ELISA for human intact osteocalcin and its utility in diagnosis and management of osteoporosis.

Clin Chim Acta 2018 Dec 8. Epub 2018 Dec 8.

Department of Molecular Immunodiagnostics, ICMR-National Institute for Research In Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai, India. Electronic address:

Background: Serum Osteocalcin (OC) is a biomarker for evaluating bone turnover in humans. Commercial kits of OC in India are imported, hence expensive prohibiting their use in routine screening of osteoporosis. The present study describes the development, validation of human OC ELISA and establishes cut off values for its use in screening and management of women at risk for osteoporosis. Read More

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December 2018
2 Reads

Efficiency of excitation energy trapping in the green photosynthetic bacterium Chlorobaculum tepidum.

Biochim Biophys Acta Bioenerg 2018 Dec 8. Epub 2018 Dec 8.

Laboratory of Biophysics, Wageningen University, Wageningen, the Netherlands; MicroSpectroscopy Research Facility, Wageningen University, Wageningen, the Netherlands. Electronic address:

During the millions of years of evolution, photosynthetic organisms have adapted to almost all terrestrial and aquatic habitats, although some environments are obviously more suitable for photosynthesis than others. Photosynthetic organisms living in low-light conditions require on the one hand a large light-harvesting apparatus to absorb as many photons as possible. On the other hand, the excitation trapping time scales with the size of the light-harvesting system, and the longer the distance over which the formed excitations have to be transferred, the larger the probability to lose excitations. Read More

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December 2018

High versus low dose caffeine in preterm infants.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Paediatrics, Lund University, Skane University Hospital, Lund, Sweden.

We are grateful to Vliegenthart et al for their letter (1) commenting on our systematic review, which compared the use of high versus low dose caffeine in preterm infants (2). A clear definition of the inclusion criteria in a systematic review is an essential step to minimise the risk of intellectual bias. Vliegenthart et al state that pooling the results of the studies they identified did not affect the estimate of the effect size of the outcome of bronchopulmonary dysplasia. Read More

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December 2018

Models.

Acta Physiol (Oxf) 2018 Dec 7:e13237. Epub 2018 Dec 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Vegetative Physiology.

A look at the history of science supports this statement. Harvey's discovery of the blood circulation, published in 1628, is undoubtedly among the most important events in the history of physiology. Although Harvey's concept of blood circulation was brilliant at that time, it was far away from a comprehensive insight into the circulatory system. Read More

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December 2018
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Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle-aged Caucasians: the Northern Finland Birth Cohort Eye study.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle-aged Caucasians.

Methods: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi-automated computer-assisted program. Read More

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December 2018
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Providing very preterm infants with donor human milk led to faster breastfeeding rates but worse biometric gains.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Neonatology, Puerta de Hierro Majadahonda University Hospital, Madrid.

Aim: To evaluate the immediate clinical impact of donor human milk availability in a NICU about nutritional, clinical and biometric parameters.

Methods: This retrospective-cohort study included 28-32 weeks gestational age born at our hospital in a three-year period before and after the donor human milk implementation. Data about starting, advance and discharge enteral nutrition, clinical outcomes, hospital stay and biometrics, was collected. Read More

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December 2018
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Review shows that thyroid hormone substitution could benefit transient hypothyroxinaemia of prematurity but treatment strategies need to be clarified.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Neonatology, University Hospitals Leuven, KU, Leuven, Belgium.

Aim: Thyroid hormones are crucial for fetal and neonatal brain development. This paper provides an overview of the normal role of thyroid hormones in fetal brain development and the pathophysiology of transient hypothyroxinaemia of prematurity (THOP). It also discusses the diagnostic and therapeutic controversies around THOP and looks at directions for future research. Read More

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December 2018
1 Read

Corrigendum.

Authors:

Acta Paediatr 2019 Jan;108(1):190

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January 2019
2 Reads

Highlights in this issue.

Acta Paediatr 2019 Jan;108(1):6-7

Acta Paediatrica, Stockholm, Sweden.

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January 2019

Acknowledgements.

Authors:

Acta Paediatr 2019 Jan;108(1):185-189

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January 2019
1 Read

Probiotics can stimulate initial head growth in premature infants.

Authors:
Olivier Claris

Acta Paediatr 2019 Jan;108(1):10-11

Department of Neonatology, Hospices Civils de Lyon, Hôpital Femme Mère Enfants, Claude Bernard University, Lyon, France.

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January 2019
2 Reads

A meta-analysis of neurodevelopmental outcomes at 4-10 years in children born at 22-25 weeks gestation.

Acta Paediatr 2018 Dec 10. Epub 2018 Dec 10.

University of Ottawa, Faculty of Medicine, Ottawa, Canada.

Aim: To update our meta-analysis on neurodevelopmental disability rates in children born at 22-25 weeks gestation. The main outcome measure was rates of neurodevelopmental disability in survivors at age 4-10 years.

Methods: We used a peer-reviewed electronic and grey search to identify articles. Read More

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December 2018

Opioids are rarely prescribed for children with acute non-procedural pain in Italian emergency departments.

Acta Paediatr 2018 Dec 8. Epub 2018 Dec 8.

Director of Paediatric Pain and Palliative Care Service, Department of Women's and Children's Health, University Hospital, Padua, Italy.

Pain is a major cause of admissions to pediatric emergency departments, but is often inappropriately managed (1). The findings of the Pain Practice in Italian Pediatric Emergency Departments on the appropriate use of paracetamol and ibuprofen have previously been reported (1,2). This multicentre, retrospective study evaluated the prescription of opioids given to patients up to the age of 14 with acute non-procedural pain by 18 Italian emergency departments between October 2014 and January 2015. Read More

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December 2018

Six-minute screening test can provide valid information about the skills that underlie childhood reading and cognitive abilities.

Acta Paediatr 2018 Dec 9. Epub 2018 Dec 9.

Educational Neuroimaging Center, Faculty of Education in Science and Technology, Technion, Haifa, Israel.

Aim: Reading difficulties can have complex origins and diagnostic measures can be expensive and time consuming. We tested Zippy6, a six-minute screening test that we developed, to see how it compared with a battery of established screening tools.

Methods: This study was carried out at Cincinnati Children's Hospital Medical Center, USA, from 2014-2016. Read More

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December 2018

Mechanical loading releases osteoclastogenesis-modulating factors through stimulation of the P2X7 receptor in hematopoietic progenitor cells.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical and Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden.

Mechanical instability of bone implants stimulate osteoclast differentiation and peri-implant bone loss, leading to prosthetic loosening. It is unclear which cells at the periprosthetic interface transduce mechanical signals into a biochemical response, and subsequently facilitate bone loss. We hypothesized that mechanical overloading of hematopoietic bone marrow progenitor cells, which are located near to the inserted bone implants, stimulates the release of osteoclast-inducing soluble factors. Read More

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December 2018

Practice variation among Dutch paediatricians in palivizumab prescription rates: the importance of parental counselling approach.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Paediatrics, Isala, Zwolle.

Aim: To investigate differences in palivizumab prescription rates between Dutch paediatricians, and the role of parent counselling in this practice variation.

Methods: A retrospective chart review of premature infants <32 weeks of gestation, aged
Results: We included 208 patients, 133 (64%) of whom received palivizumab. Read More

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December 2018

Infants who die in shared sleeping situations differ from those who die while sleeping alone.

Acta Paediatr 2018 Dec 10. Epub 2018 Dec 10.

Discipline of Anatomy and Pathology, Adelaide Medical School, The University of Adelaide, Adelaide, Australia.

Aim: To determine whether there are differences between infants who are sharing a sleeping surface with others, compared to those who die alone.

Methods: A literature review was undertaken of pubmed and google scholar databases using search terms: sudden infant death syndrome, SIDS, cosleeping and overlaying.

Results: Statistically significant differences were found between the two groups in the sex ratios, and in staining of brain sections for β-amyloid precursor protein (β-APP), glial fibrillary acidic protein (GFAP) and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL). Read More

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December 2018

Fasting insulin resistance affects the prevalence of metabolically healthy obesity in Brazilian adolescents.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Aim: We aimed to assess the influence of fasting insulin resistance on metabolically healthy obesity (MHO) prevalence in adolescents and to identify associated factors.

Methods: This retrospective, registry-based, cross-sectional study included 418 (51.9% girls) 10-18 year-old adolescents with obesity from a tertiary outpatient clinic in Sao Paulo, Brazil, between 2009 and 2013. Read More

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December 2018
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Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Inserm, UMR1153, Centre de Recherche en Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), équipe Épidémiologie Périnatale, Obstétricale et Pédiatrique (ÉPOPé) Labex GR-Ex, Paris, France.

Sacri A-S, de Lauzon-Guillain B, Dufourg M-D, Bois C, Charles M A, Chalumeau M. Iron-fortified formula use in young children and association with socioeconomic factors in the French nationwide ELFE cohort.

Aim: To study the rate of iron-fortified infant formula (IFF) use in young children in France and its association with socioeconomic factors. Read More

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December 2018

Novel compound heterozygous FATP4 mutations caused ichthyosis prematurity syndrome in Spanish sisters.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Fundación Pública Galega de Medicina Xenómica-SERGAS, CIBERER, IDIS, Grupo de Medicina Xenómica-Universidade de Santiago de Compostela, Santiago de CompostelaSpain.

Ichthyosis prematurity syndrome (IPS), or ichthyosis congenita type IV, is a rare syndromic form of autosomic recessive ichthyosis caused by mutations in fatty acid transport protein 4 (FATP4), also known as SLC27A4. Patients with a disrupted FATP4 gene are usually born prematurely with thick desquamating skin and other complications, such as neonatal asphyxia, eosinophilia and elevated serum immunoglobulin E levels. Symptoms become less severe after the first months of life, evolving to non-scaly ichthyosis with follicular hyperkeratosis in adulthood (1, 2). Read More

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December 2018
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Vitreous Wiping, a new technique for removal of vitreous cortex remnants during vitrectomy.

Acta Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Department of Vitreoretinal Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: Unremoved vitreoschisis-induced vitreous cortex remnants (VCR) are associated with macular pathology. When present on the retinal periphery, they may play a role in proliferative vitreoretinopathy and retinal detachment after vitrectomy. Existing instruments for their removal involve substantial risk of iatrogenic retinal damage. Read More

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December 2018

Model that predicted death or disabilities in premature infants was valid at seven years of age.

Acta Paediatr 2018 Dec 8. Epub 2018 Dec 8.

Neonatologist. 12 de Octubre University Hospital, Madrid, Spain.

Aim: Validated a model that used bronchopulmonary dysplasia (BPD), brain injuries measured using ultrasound and retinopathy of prematurity (ROP) to predict late death or disability in premature infants at seven years of age.

Methods: A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity and the effect that the combination of morbidities had on the seven-year outcomes. Read More

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December 2018

Intrathecal betamethasone for cancer pain: A study of its analgesic efficacy and safety.

Acta Anaesthesiol Scand 2018 Dec 7. Epub 2018 Dec 7.

Department of Anesthesiology, Kansai Medical University Medical Center, Moriguchi, Japan.

Background: A preliminary study has shown effective cancer pain relief by intrathecal betamethasone (ITB). However, further evidence is needed to support this new approach.

Methods: Cancer patients with opioid-resistant pain received lumbar intrathecal administration of betamethasone 2 or 3 mg once a week for 28 days. Read More

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December 2018
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A survey demonstrates limited palliative care structures in paediatric nephrology from the perspective of a multidisciplinary healthcare team.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Paediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité - Universitätsmedizin Berlin, Germany.

Aim: Children and adolescents with end stage renal disease face a high morbidity and mortality. Palliative care provides a multidisciplinary approach to reduce disease burden and improve quality of life. This study evaluated concepts and current structures of palliative care from the perspective of a multidisciplinary paediatric nephrology team including physicians, nurses and psychosocial health professionals. Read More

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December 2018
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