Naloxone attenuates ischemic brain injury in rats through suppressing the NIK/IKKα/NF-κB and neuronal apoptotic pathways.
- Xuan Wang,
- Zu-Jun Sun,
- Jun-Lu Wu,
- Wen-Qiang Quan,
- Wei-Dong Xiao,
- Helen Chew,
- Cui-Min Jiang,
- Dong Li
Acta Pharmacol Sin 2018 Jun 14. Epub 2018 Jun 14.
Department of Clinical Laboratory, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
Although naloxone has been documented to exert neuroprotection in animal model of cerebral ischemia, the mechanism is not well understood. In this present study we investigated whether naloxone affected the mitochondrial apoptotic pathway in ischemic brain injury of rats. SD rats were subjected to a permanent middle cerebral artery occlusion surgery, and received naloxone (0. Read More