609 results match your criteria Acta Pharmaceutica[Journal]


Topical antifungal bigels: Formulation, characterization and evaluation.

Acta Pharm 2018 Jun;68(2):223-233

Department of Clinical Pharmacy Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.

Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Read More

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http://dx.doi.org/10.2478/acph-2018-0014DOI Listing
June 2018
2 Reads

Development and evaluation of orally disintegrating tablets containing the mosapride resin complex.

Acta Pharm 2018 Jun;68(2):159-170

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.

The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, mass ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. Read More

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http://content.sciendo.com/view/journals/acph/68/2/article-p
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http://dx.doi.org/10.2478/acph-2018-0017DOI Listing
June 2018
20 Reads

Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3.

Acta Pharm 2018 Jun;68(2):211-222

Laboratory of Kidney Carcinoma, Ningbo Urology and Nephrology Hospital, Urology and Nephrology Institute of Ningbo University, Ningbo, Zhejiang315000, P.R. China.

Bladder cancer (BCa) is one of the most common urinary cancers. The present study aims to investigate whether Paeoniflorin (Pae) can exert inhibitory effects on BCa. The results showed that Pae inhibited proliferation of human BCa cell lines in a concentration- and time-dependent manner. Read More

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http://dx.doi.org/10.2478/acph-2018-0013DOI Listing
June 2018
2 Reads

Spectrofluorimetric method for atenolol determination based on gold nanoparticles.

Acta Pharm 2018 Jun;68(2):243-250

Department of Chemistry, College of Science, King Faisal University, Hofuf, Saudi Arabia.

A simple and sensitive spectrofluorimetric method for determination of atenolol (ATE) using gold nanoparticles (AuNPs) was developed. The method is based on the quenching effect of atenolol on photoluminescence of AuNPs at λem = 705 nm. Variables affecting luminescence of gold nanoparticles such as the solvent, pH value and surfactant were studied and optimized. Read More

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http://dx.doi.org/10.2478/acph-2018-0020DOI Listing
June 2018
1 Read

Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats.

Acta Pharm 2018 Jun;68(2):145-157

Department of Pharmaceutics, Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050 China.

Simvastatin is poorly bioavailable because it is practically insoluble in water and shows dissolution rate-limited absorption. Solubilizing effects of several β-cyclodextrin (βCD) derivatives such as HPβCD, SBEβCD and DMβCD on simvastatin in aqueous solution were investigated using the phase solubility technique. The solubility diagram of simvastatin with each βCD derivative could be classified as AL-type, indicating soluble complex formation of 1:1 stoichiometry. Read More

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http://dx.doi.org/10.2478/acph-2018-0016DOI Listing
June 2018
8 Reads

Reversed phase HPLC for strontium ranelate: Method development and validation applying experimental design.

Acta Pharm 2018 Jun;68(2):171-183

Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Medicine and Pharmacy, 540139, Tîrgu Mureș Romania.

A reverse-phase HPLC (RP-HPLC) method was developed for strontium ranelate using a full factorial, screening experimental design. The analytical procedure was validated according to international guidelines for linearity, selectivity, sensitivity, accuracy and precision. A separate experimental design was used to demonstrate the robustness of the method. Read More

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http://dx.doi.org/10.2478/acph-2018-0019DOI Listing
June 2018
22 Reads

In vitro oxidative stress regulatory potential of Citrullus colocynthis and Tephrosia apollinea.

Acta Pharm 2018 Jun;68(2):235-242

UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz,Nizwa-616, Oman.

The present study investigates the potential role of medicinal plants Citrullus colocynthis and Tephrosia apollinea in ameliorating the oxidative stress developed during the generation of reactive oxygen species. Organic extracts of different organs (leaf, stem and root) of these medicinal plants obtained in n-hexane, chloroform, n-butanol and water were assayed for radical scavenging, total antioxidant capacity, anti-lipid peroxidation and reduced glutathione. The total phenolic content (TPC) of both selected medicinal plants was also evaluated. Read More

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http://dx.doi.org/10.2478/acph-2018-0012DOI Listing
June 2018
7 Reads

Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats.

Acta Pharm 2018 Jun;68(2):185-197

Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand40002.

Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Read More

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http://dx.doi.org/10.2478/acph-2018-0015DOI Listing
June 2018
4 Reads

TLC determination of some flavanones in the buds of different genus Populus species and hybrids.

Acta Pharm 2018 Jun;68(2):199-210

Department of Pharmacognosy with Medicinal Plants Garden, Faculty of Pharmacy with Subfaculty of Laboratory Medicine, Medical University of Gdańsk 80-416 Gdańsk, Poland.

Flavonoids in the buds of eight Populus species and hybrids were detected and compared with the aid of an optimized TLC method. Separation of 17 flavonoid aglycones belonging to different groups, namely, flavones, flavonols, flavanones and flavanonols, previously described as constituents of poplar buds, was performed on silica gel plates using a hexane/ethyl acetate/formic acid (60:40:1.3, V/V/V) mixture as the mobile phase. Read More

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http://dx.doi.org/10.2478/acph-2018-0018DOI Listing
June 2018
9 Reads

Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity.

Acta Pharm 2018 Jun;68(2):129-144

University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)Romania.

The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18. Read More

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http://dx.doi.org/10.2478/acph-2018-0011DOI Listing
June 2018
3 Reads

Comparative chemical investigation and evaluation of antioxidant and tyrosinase inhibitory effects of Withania somnifera (L.) Dunal and Solanum nigrum (L.) berries.

Acta Pharm 2018 Mar;68(1):47-60

1Faculty of Pharmacy and Alternative Medicine The Islamia University of Bahawalpur 63100, Pakistan.

In the present study, berries of two different species of Solanaceae family, Withania somnifera (WS) and Solanum nigrum (SN), were extracted in methanol and then fractionated with solvents, ranging from non-polar to polar, for their phytochemical profiling and investigation of antioxidant and tyrosinase enzyme inhibition capacity. The methanolic extract and n-hexane, ethyl acetate (WSEA, SNEA) and aqueous fractions were chemically analyzed and evaluated for biological activity. Total flavonoids and total phenolics were quantified in WSEA (96. Read More

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http://dx.doi.org/10.2478/acph-2018-0007DOI Listing
March 2018
5 Reads

Distinguishing Smilax glabra and Smilax china rhizomes by flow-injection mass spectrometry combined with principal component analysis.

Acta Pharm 2018 Mar;68(1):87-96

2Jiangxi University of Traditional Chinese Medicine Nanchang, 330004, China.

Flow-injection mass spectrometry (FIMS) coupled with a chemometric method is proposed in this study to profile and distinguish between rhizomes of Smilax glabra (S. glabra) and Smilax china (S. china). Read More

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http://dx.doi.org/10.2478/acph-2018-0003DOI Listing
March 2018
4 Reads

Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis.

Acta Pharm 2018 Mar;68(1):19-30

1Digestion Internal Medicine Department, Xijing Hospital The First Affiliated Hospital of the Fourth Military Medical University Xi'an Shaanxi 710000, China.

The purpose of this study was to compare the efficacy of nucleoside analogues (NAs) in the treatment of HBV-related liver failure. The data of patients with HBV-related liver failure treated with nucleoside analogues were used to conduct a network meta-analysis. A total of 1660 patients from 12 articles about the efficacy of lamivudine, entecavir, telbivudine and tenofovir for HBV-related liver failure treatment were recruited in the study. Read More

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http://dx.doi.org/10.2478/acph-2018-0010DOI Listing
March 2018
3 Reads

Medication adherence and health-related quality of life among patients with chronic obstructive pulmonary disease.

Acta Pharm 2018 Mar;68(1):117-125

1Chair of Social Pharmacy Faculty of Pharmacy University of Ljubljana 1000 Ljubljana, Slovenia.

This study evaluated medication adherence and health-related quality of life (HRQoL) of Slovenian patients with chronic obstructive pulmonary disease (COPD) and examined the factors associated with HRQoL. Demographic and therapy information was collected from 65 patients through interviews. The St. Read More

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http://dx.doi.org/10.2478/acph-2018-0006DOI Listing
March 2018
1 Read
1.025 Impact Factor

Chronic fluoxetine treatment induces lipid accumulation but does not alter the expression of Pref-1 in rat adipose tissue.

Acta Pharm 2018 Mar;68(1):109-115

2Department of Pharmacology and Clinical Pharmacy, University of Medicine and Pharmacy of Tîrgu Mureș, Tîrgu Mureș, Romania.

This study aims to investigate the effects of chronic fluoxetine (FLX) treatment on preadipocyte factor-1 (Pref-1) expression in subcutaneous, visceral and brown adipose tissues, and on the size of vacuoles in a dipocytes obtained from the perirenal regions in rats. Twenty-eight Wistar rats were treated with FLX at two different doses and fourteen animals received vehicle. After 40 days of treatment, the subcutaneous, perirenal and interscapular adipose tissues were collected. Read More

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http://dx.doi.org/10.2478/acph-2018-0009DOI Listing
March 2018
3 Reads

HPTLC determination of diosgenin in fenugreek seeds.

Acta Pharm 2018 Mar;68(1):97-107

1Department of Pharmacognosy with Medicinal Plants Garden Medical University of Gdańsk 80-416 Gdańsk, Poland.

A new HPTLC-densitometric method for diosgenin determination in fenugreek seeds was established after optimization of the conditions for efficient saponin extraction and acid hydrolysis. Several procedures were tested, the best of which was a three-step Soxhlet extraction, followed by hydrolysis of the obtained methanolic extract with 2 mol L-1 H2SO4. Best diosgenin separation from other hydrolysis products was obtained on HPTLC Si60F254 plates u sing a mixture of n-heptane/ethyl acetate (7:3, V/V) and modified anisaldehyde as a spraying reagent. Read More

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http://dx.doi.org/10.2478/acph-2018-0002DOI Listing
March 2018
11 Reads

Induction of xenobiotic-metabolizing enzymes in hepatocytes by beta-naphthoflavone: Time-dependent changes in activities, protein and mRNA levels.

Acta Pharm 2018 Mar;68(1):75-85

1Faculty of Pharmacy Charles University CZ-500 05 Hradec Králové Czech Republic.

In the present study, time-dependency of the induction effect of a selective inducer on the activity, protein and mRNA levels of cytochromes P450 1A1/2 (CYP1A1/2), NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTA), in primary culture of rat hepatocytes was tested and evaluated. To show the differences in responses of tested enzymes, the common aryl hydrocarbon receptor (AhR) ligand agonist, beta-naphthoflavone (BNF), was used. Induction of CYP1A1/2 by BNF was detected at all time intervals and at all levels (i. Read More

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http://dx.doi.org/10.2478/acph-2018-0005DOI Listing
March 2018
4 Reads

Advanced spectrophotometric chemometric methods for resolving the binary mixture of doxylamine succinate and pyridoxine hydrochloride.

Acta Pharm 2018 Mar;68(1):61-73

1Department of Pharmaceutical Sciences Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria.

The prediction power of partial least squares (PLS) and multivariate curve resolution-alternating least squares (MCR-ALS) methods have been studied for simultaneous quantitative analysis of the binary drug combination - doxylamine succinate and pyridoxine hydrochloride. Analysis of first-order UV overlapped spectra was performed using different PLS models - classical PLS1 and PLS2 as well as partial robust M-regression (PRM). These linear models were compared to MCR-ALS with equality and correlation constraints (MCR-ALS-CC). Read More

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http://dx.doi.org/10.2478/acph-2018-0008DOI Listing
March 2018
13 Reads

A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity.

Acta Pharm 2018 Mar;68(1):31-46

1Division of Product Quality and Research Center for Drug Evaluation and Research Food and Drug Administration Maryland, USA.

Coumadin® a nd s everal generic products of warfarin s odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical properties of the drug and drug product may change when the crystalline drug transforms to amorphous form. Read More

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http://dx.doi.org/10.2478/acph-2018-0001DOI Listing
March 2018
5 Reads

Effective anti-adhesives of uropathogenic Escherichia coli.

Acta Pharm 2018 Mar;68(1):1-18

3Department of Biomedical Sciences University Centre Varaždin University North, 42000 Varaždin, Croatia.

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most common infectious diseases in humans. Due to their frequent occurrence in the community and nosocomial settings, as well as the development of resistance to the commonly prescribed antimicrobial agents, an enormous financial burden is placed on healthcare systems around the world. Therefore, novel approaches to the prevention and treatment of UTIs are needed. Read More

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http://dx.doi.org/10.2478/acph-2018-0004DOI Listing
March 2018
5 Reads

Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile.

Acta Pharm 2017 Dec;67(4):495-510

2Department of Chemistry Faculty of Science, Helwan University Ain Helwan, Cairo A. R. Egypt.

Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d]thiazole derivatives. Cytotoxicity effects of the newly synthesized products against six cancer cell lines, namely, human gastric cancer (NUGC), human colon cancer (DLD- 1), human liver cancer (HA22T and HEPG-2), human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated. Read More

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http://dx.doi.org/10.1515/acph-2017-0040DOI Listing
December 2017
4 Reads

Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance.

Acta Pharm 2017 Dec;67(4):415-439

2Department of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia.

Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/ caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth- 7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Read More

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http://dx.doi.org/10.1515/acph-2017-0036DOI Listing
December 2017
15 Reads

Synthesis and evaluation of antitumor activity of new 4-substituted thieno[3,2-d]pyrimidine and thienotriazolopyrimidine derivatives.

Acta Pharm 2017 Dec;67(4):527-542

1Al-Imam Mohammad Ibn Saud Islamic University (IMSIU) Faculty of Science Department of Chemistry P. O. Box 90950, Riyadh 11623 Kingdom of Saudi Arabia.

3-Methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[3,2-d]pyrimidin- 4(1H)-one (2), on treatment with phosphorous oxychoride, affored 4-chloro-3-methyl-6-phenyl -thieno[3,2-d]pyrimidine- 2(3H)-thione (3). A series of novel 6-phenyl-thieno[3,2-d]pyrimidine derivatives 4-9 bearing different functional groups were synthesized via treatment of compound 3 with different reagents. On the other hand, compound 2 was used to synthesize ethyl-[(3-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[ 3,2-d]pyrimidin-4-yl)-oxy]acetate (10), 2-hydrazinyl- -3-methyl-6-phenyl-thieno[3,2-d]pyrimidin-4(3H)-one (11), 3-methyl-2-(methyl-sulfanyl)-6-phenyl-thieno[3,2-d]pyrimidin- 4(3H)-one (12) and N-(phenyl)/4-chlorophenyl or methoxy- phenyl)-2-[(3-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[ 3,2-d]pyrimidin-2-yl)-sulfanyl]-acetamide (13a-c). Read More

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http://dx.doi.org/10.1515/acph-2017-0039DOI Listing
December 2017
9 Reads

A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi.

Acta Pharm 2017 Dec;67(4):557-567

1School of Chemistry Sun Yat-Sen University, Guangzhou 510275, P. R. China.

In this study, the effect of four xyloketals 1-4 on store-operated calcium entry (SOCE) was investigated in primary distal pulmonary arterial smooth muscle cells (PASMCs) isolated from mice. The results showed that xyloketal A (1), an unusual ketal with C-3 symmetry, exhibited strong SOCE blocking activity. Secretion of interleukin-8 (IL-8) was also inhibited by xyloketal A. Read More

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http://dx.doi.org/10.1515/acph-2017-0032DOI Listing
December 2017
4 Reads

Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice.

Acta Pharm 2017 Dec;67(4):543-555

5Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy The University of Jordan, Amman 11942, Jordan.

Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. Therefore, the most recent guidelines for immunotoxicological evaluation of drugs were consulted to investigate the immunomodulatory effects of lamotrigine, a newer antiepileptic drug, in BALB/c mice. These included the in vivo effects of lamotrigine on delayed-type hypersensitivity (DTH) response to sheep red blood cell (SRBC) antigens, hemagglutination titer assays and hematological changes. Read More

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http://dx.doi.org/10.1515/acph-2017-0035DOI Listing
December 2017
5 Reads

Influence of plasma on the physical properties of ointments with quercetin.

Acta Pharm 2017 Dec;67(4):569-578

3Pharmaceutical Research and Production Plant »Biochefa« Sosnowiec, Poland.

Effects of two independent variables - the content of quercetin (0 or 1 or 1.5 or 5 %) and the content of plasma (0 or 2 or 4 or 6 %) - on the organoleptic properties and rheological parameters of model formulations prepared on an amphiphilic base were estimated. The consistency of all ointments was uniform, and the content of quercetin and plasma lay within the predefined range. Read More

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http://dx.doi.org/10.1515/acph-2017-0038DOI Listing
December 2017
6 Reads

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures.

Acta Pharm 2017 Dec;67(4):463-478

1Department of Inorganic and Analytical Chemistry Jagiellonian University Medical College, Faculty of Pharmacy 30-688 Kraków, Poland.

Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Read More

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http://dx.doi.org/10.1515/acph-2017-0031DOI Listing
December 2017
2 Reads

Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology.

Acta Pharm 2017 Dec;67(4):441-461

6Research and Development Mass Pharma(Pvt) Ltd, Lahore, Pakistan.

For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation microencapsulation process from carnauba wax and glyceryl monostearate, central composite design was used to study the impact of independent variables on yield (Y1), entrapment efficiency (Y2) and drug release (Y3). SLMs having a 10-40 μm size range, with good rheological behavior and spherical smooth surfaces, were produced. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry pointed to compatibility between formulation components and the zeta-potential study confirmed better stability due to the presence of negative charge (-20 to -40 mV). Read More

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http://dx.doi.org/10.1515/acph-2017-0034DOI Listing
December 2017
19 Reads

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury.

Acta Pharm 2017 Dec;67(4):479-494

1Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro Dongdaemun-gu, Seoul, 02447, Korea Republic of.

In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. Pre-treatment with IPAP ameliorated the gastric mucosal hemorrhagic lesions in ethanol/HCl- or indomethacin- treated rats. IPAP decreased mucosal hemorrhage of gastric ulcers induced by ethanol or indomethacin plus pyloric ligation in rats. Read More

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http://dx.doi.org/10.1515/acph-2017-0037DOI Listing
December 2017
19 Reads

Solving manufacturing problems for L-carnitine-L-tartrate to improve the likelihood of successful product scale-up.

Acta Pharm 2017 Dec;67(4):511-525

2Research & Development Department, Mepaco-Medifood Company, El Sharkia, Egypt.

L-carnitine-L-tartrate, a non-essential amino acid, is hygroscopic. This causes a problem in tablet production due to pronounced adhesion of tablets to punches. A 33 full factorial design was adopted to suggest a tablet formulation. Read More

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http://dx.doi.org/10.1515/acph-2017-0033DOI Listing
December 2017

Development of a new HPLC method for wogonin in rat plasma: Compatibility of standard and test samples.

Acta Pharm 2017 Sep;67(3):373-384

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In the current paper, an HPLC/UV method was developed and validated for determination of wogonin in plasma. Considerable attention was paid to the preparation of standard samples and factors affecting drug distribution. A preparation procedure was devised to simulate the conditions the drug is expected to experience in vivo while pointing to the shortcomings of previously published methods. Read More

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http://dx.doi.org/10.1515/acph-2017-0029DOI Listing
September 2017
61 Reads

Pharmacological activities of some triazinopyrazolothieno pyrimidine derivatives.

Acta Pharm 2017 Sep;67(3):407-414

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Triazinopyrazolothieno pyrimidine derivatives 1-5 were evaluated for their anti-inflammatory, analgesic and anticancer activities and acute toxicity. Anti-inflammatory activity of the compounds was studied using the carrageenan test. All tested compounds showed analgesic activity, 3-methoxycarbonyl-4,6-dimethyl-8-[(N-methylindolyl)methyl] pyrimido [5',4':4,5]thieno [3',2'-3,4]pyrazolo [5,1-c]triazine (4) showed activity comparable to that of diclofenac. Read More

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http://dx.doi.org/10.1515/acph-2017-0022DOI Listing
September 2017
3 Reads

Axonal excitability and conduction alterations caused by levobupivacaine in rat.

Acta Pharm 2017 Sep;67(3):293-307

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In this study, effects of the long-acting amide-type local anesthetic levobupivacaine on axonal conduction and excitability parameters of the rat sciatic nerve were thoroughly examined both in vitro and in vivo. In order to deduce its effects on isolated nerve conduction, compound nerve action potential (CNAP) recordings were performed using the suction method over sciatic nerves of Wistar rats before and after administration of 0.05 % (1. Read More

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http://dx.doi.org/10.1515/acph-2017-0025DOI Listing
September 2017
12 Reads

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents.

Acta Pharm 2017 Sep;67(3):275-292

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A novel series of carbamothioylamino-benzene-sulfonamide-thiophene-carboxylates 4a-c and thieno[3,2-d]pyrimidin-2-yl-amino-benzene-sulfonamides 5a-c were synthesized in a series of synthetic steps and were used as key intermediates for the synthesis of thienotriazolopyrimidine-benzene-sulfonamide derivatives 6a-c and 7a-c. Thieno[3,2-d]pyrimidinones (8 and 9) were also prepared. Compound 9 was used as an intermediate for the synthesis of imidazole/1,2,4-triazole and tetrazine functionalized thieno[3,2-d]pyrimidine derivatives (10-12). Read More

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http://dx.doi.org/10.1515/acph-2017-0028DOI Listing
September 2017
10 Reads

Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers.

Acta Pharm 2017 Sep;67(3):357-371

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In order to investigate the potential of nanostructured lipid carriers for efficient and targeted delivery of curcumin, the pharmacokinetic parameters of curcumin-loaded nanostructured lipid carriers (Cur-NLC) were evaluated in rats after a single intraperitoneal dose of Cur-NLC. In addition, the anticancer activity of Cur-NLC against human lung adenocarcinoma A549 cells was verified by a cellular uptake study, and a cytotoxicity and apoptosis assay. Bioavailability of Cur-NLC was better than that of native curcumin (p > 0. Read More

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http://dx.doi.org/10.1515/acph-2017-0021DOI Listing
September 2017
73 Reads

Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation.

Acta Pharm 2017 Sep;67(3):309-324

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The present study describes an efficient and ecofriendly, ultrasound, one-pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3-triazoles tethered with fluorinated 1,2,4-triazole-benzothiazole molecular conjugates. It involved three-component condensation of the appropriate bromoacetamide benzothiazole, sodium azide and 4-alkyl/aryl-5-(2-fluorophenyl)-3-(prop-2-ynylthio)-1,2,4-triazoles 4a-e through a Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction. This approach involves in situ generation of azidoacetamide benzothiazole, followed by condensation with terminal alkynes in the presence of CuSO4/Na-ascorbate in aqueous DMSO under both conventional and ultrasound conditions. Read More

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http://dx.doi.org/10.1515/acph-2017-0024DOI Listing
September 2017
2 Reads

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation.

Acta Pharm 2017 Sep;67(3):325-339

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The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Read More

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http://dx.doi.org/10.1515/acph-2017-0027DOI Listing
September 2017
13 Reads
1.025 Impact Factor

Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase.

Acta Pharm 2017 Sep;67(3):385-395

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Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its rapid acquisition. During synthesis, solvent choice was found to be an important parameter for better curcumin yield and high purity. Read More

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http://dx.doi.org/10.1515/acph-2017-0023DOI Listing
September 2017
25 Reads

Influence of novel oral anticoagulants on anticoagulation care management.

Acta Pharm 2017 Sep;67(3):397-406

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Anticoagulation treatment was recently improved by the introduction of novel oral anticoagulants (NOACs). Using a combination of qualitative and quantitative methods, this study explores the effects of the introduction of NOACs on anticoagulation care in Slovenia. Face-to-face interviews with key stakeholders revealed evolvement and challenges of anticoagulation care from different perspectives. Read More

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http://dx.doi.org/10.1515/acph-2017-0030DOI Listing
September 2017
18 Reads

Synthesis and photodegradation studies of analogues of muscle relaxant 1,4-dihydropyridine compounds.

Acta Pharm 2017 Sep;67(3):341-355

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This paper describes the synthesis of 1,4-dihydropyridine compounds (DHPs) endowed with good muscle relaxant activity and stability to light. Six new condensed DHPs were synthesized by the microwave irradiation method. A long-chain ester moiety [2-(methacryloyloxy)ethyl] and various substituents on the phenyl ring were demonstrated to affect the muscle relaxant activity occurring in isolated rabbit gastric fundus smooth muscle strips. Read More

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http://dx.doi.org/10.1515/acph-2017-0026DOI Listing
September 2017
1 Read

Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells.

Acta Pharm 2017 Jun;67(2):257-264

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The main aim of the current research was to study the effect of porphyra-334, one of mycosporine-like amino acids (MAAs), well known as UV-absorbing compounds, on UVinduced apoptosis in human immortalized keratinocyte (HaCaT) cells. Due to their UV-screening capacity and ability to prevent UV-induced DNA damage, MAAs have recently attracted considerable attention in both industry and research in pharmacology. Herein, human HaCaT cells were used to determine the biological activities of porphyra- 334 by various in vitro assays, including proliferation, apoptosis and Western blot assays. Read More

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http://content.sciendo.com/view/journals/acph/67/2/article-p
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http://dx.doi.org/10.1515/acph-2017-0015DOI Listing
June 2017
8 Reads

Testing of resveratrol microemulsion photostability and protective effect against UV induced oxidative stress.

Acta Pharm 2017 Jun;67(2):247-256

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Resveratrol is well known for its antioxidant activity and susceptibility to ultraviolet radiation. Development of formulations providing improved stability and relevant drug delivery of resveratrol is still a challenging task. The aim of this study was to determine protective characteristics of formulated microemulsions by evaluating photoisomerization of resveratrol and to investigate the effects of resveratrol on human keratinocyte cells under oxidative stress caused by ultraviolet radiation. Read More

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http://dx.doi.org/10.1515/acph-2017-0018DOI Listing
June 2017
15 Reads

Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties.

Acta Pharm 2017 Jun;67(2):169-186

90112.

In this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all formulations were in the range of 6-7. Read More

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http://dx.doi.org/10.1515/acph-2017-0011DOI Listing
June 2017
17 Reads

Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels.

Acta Pharm 2017 Jun;67(2):215-226

, D.F.

γ-Ethyl-γ-phenyl-butyrolactone (EFBL) is a structural combination of the anticonvulsant γ-hydroxy-γ-ethyl-γ-phenylbutyramide (HEPB) and the hypnotic γ-butyrolactone (GBL), which inherits both properties. To clarify its mechanism of action, the effects of EFBL, GBL and HEPB on dopamine (DA) and noradrenaline (NA) brain levels were investigated. Influences of chlorpromazine, phenelzine and aminooxyacetic acid were also studied. Read More

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http://dx.doi.org/10.1515/acph-2017-0014DOI Listing

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets.

Acta Pharm 2017 Jun;67(2):237-246

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Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. Read More

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http://dx.doi.org/10.1515/acph-2017-0017DOI Listing
June 2017
7 Reads

Comparing monolithic and fused core HPLC columns for fast chromatographic analysis of fat-soluble vitamins.

Acta Pharm 2017 Jun;67(2):203-213

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HPLC stationary phases of monolithic and fused core type can be used to achieve fast chromatographic separation as an alternative to UPLC. In this study, monolithic and fused core stationary phases are compared for fast separation of four fat-soluble vitamins. Three new methods on the first and second generation monolithic silica RP-18e columns and a fused core pentafluoro-phenyl propyl column were developed. Read More

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http://dx.doi.org/10.1515/acph-2017-0013DOI Listing
June 2017
6 Reads

Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system.

Acta Pharm 2017 Jun;67(2):149-168

, 90112.

In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7. Read More

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http://dx.doi.org/10.1515/acph-2017-0020DOI Listing
June 2017
5 Reads

Real-practice thromboprophylaxis in atrial fibrillation.

Acta Pharm 2017 Jun;67(2):227-236

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This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation (NVAF) in everyday clinical practice. Out of 6,138 NVAF patients, only 3,024 received vitamin K antagonist (VKA). Read More

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http://dx.doi.org/10.1515/acph-2017-0016DOI Listing
June 2017
60 Reads

Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits.

Acta Pharm 2017 Jun;67(2):187-202

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The aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12. Read More

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.9549
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http://content.sciendo.com/view/journals/acph/67/2/article-p
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http://dx.doi.org/10.1515/acph-2017-0019DOI Listing
June 2017
70 Reads

The bioguided fractionation and pharmacological activity of an endemic Salix canariensis species.

Acta Pharm 2017 Jun;67(2):265-273

, Tenerife, Canary Islands.

The present study was designed to confirm the wide traditional use of treating pain with Salix canariensis, an endemic species of the Macaronesian region. The active compounds were identified. Pharmacological activities were explored in experimental animals by acetic acid-induced writhing, formalin and Levy's tests, and bioactive compounds were identified after a bio-guided fractionation of the most active organic extract. Read More

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http://dx.doi.org/10.1515/acph-2017-0012DOI Listing
June 2017
31 Reads