715 results match your criteria Acta Pharmaceutica[Journal]


Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents.

Acta Pharm 2020 Dec;70(4):499-513

Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University, 26470Eskişehir Turkey.

The synthesis of new N-(5-substituted-1,3,4-thiadiazol-2-yl)-2-[(5-(substituted amino)-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives and investigation of their anticancer activities were the aims of this work. All the new compounds' structures were elucidated by elemental analyses, IR, 1H NMR, 13C NMR and MS spectral data. Anticancer activity studies of the compounds were evaluated against MCF-7 and A549 tumor cell lines. Read More

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http://dx.doi.org/10.2478/acph-2020-0034DOI Listing
December 2020

Exploring the potential effect and mechanisms of protocatechuic acid on human hair follicle melanocytes.

Acta Pharm 2020 Dec;70(4):539-549

Department of plastic and aesthetic laser surgery, The people's Hospital of Hunan province, 1st Affiliated Hospital of Hunan Normal University Changsha410005, Hunan,China.

This study aims to evaluate the effect of protocatechuic acid (PCA) on human hair follicle melanocytes (HFM). Normal primary HFM were isolated and cultured till logarithmic period of second passage, then treated with different concentrations of PCA (0.1-200 μmol L-1) to study the cell proliferation, melanin contents, tyrosinase activity and protein and mRNA expression of melanogenic genes (tyrosinase-related protein 1 (TRP-1), tyrosinase-related protein 2 (TRP-2), and microphthalmia-associated transcription factor (MITF)) in the cultured HFM. Read More

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http://dx.doi.org/10.2478/acph-2020-0023DOI Listing
December 2020

Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability.

Acta Pharm 2020 Dec;70(4):483-498

Key Laboratory of Biorheological Science and Technology, Ministry of Education Bioengineering College, Chongqing University, Chongqing, 400044 People's Republic ofChina.

The aim of this work is to improve the solubility and bioavailability of chlortetracycline and the function of the immune response. Chlortetracycline bisulfate and chlortetracycline mesylate were successfully synthesized and characterized with several techniques, including spectroscopy, chromatography and mass spectrometry, which demonstrated that the C4-dimethylamino group of chlortetracycline can accept a proton from sulfuric acid and methanesulfonic acid to form the corresponding salts. In addition, chlortetracycline bisulfate and chlortetracycline mesylate were more soluble in water than chlortetracycline hydrochloride, but the antibacterial activity was not enhanced. Read More

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http://dx.doi.org/10.2478/acph-2020-0041DOI Listing
December 2020

Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads.

Acta Pharm 2020 Dec;70(4):527-538

Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 11635Athens, Greece.

A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6. Read More

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http://dx.doi.org/10.2478/acph-2020-0037DOI Listing
December 2020

Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis.

Acta Pharm 2020 Dec;70(4):515-525

Department of Pharmacology and Toxicology, College of Pharmacy Taibah University, Al-Madinah Al-Munawwarah,Saudi Arabia.

Cisplatin-induced nephrotoxicity limits its anticancer effectiveness, thus this study's aim was to assess the potential modulatory effect of perindopril on cisplatin-induced nephrotoxicity and to elucidate the possible underlying mechanisms. Renal dysfunction was induced in mice by a single injection of cisplatin (10 mg kg-1, i.p. Read More

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http://dx.doi.org/10.2478/acph-2020-0033DOI Listing
December 2020

Antitumor effect of a pyrazolone-based-complex [Cu(PMPP-SAL)(EtOH)] against murine melanoma B16 cell in vitro and in vivo.

Acta Pharm 2020 Dec;70(4):561-575

Xinjiang Key Laboratory of Biological Resources and Genetic Engineering College of Life Science and Technology Xinjiang University, Urumqi830046 PRChina.

Pyrazolone-based derivative metal complexes were reported to have cytotoxicity in some tumor cells. In this study, the antitumor effect of [Cu(PMPP-SAL)(EtOH)] (PMPP-SAL = N-(1-phenyl-3-methyl-4-propenylidene-5-pyrazolone)- salicylidene hydrazide anion) in murine melanoma B16 cells in vitro and in vivo was investigated. The results showed that [Cu(PMPP-SAL)(EtOH)] inhibited the survival of B16 cells in vitro, and the IC50 value was superior to cisplatin (DDP) (p < 0. Read More

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http://dx.doi.org/10.2478/acph-2020-0040DOI Listing
December 2020

HPLC method development for fampridine using Analytical Quality by Design approach.

Acta Pharm 2020 Dec;70(4):465-482

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology of Tîrgu Mureș540139,Tîrgu Mureș, Romania.

Offering a systematic and multivariate analysis of the analytical procedure, development and validation of HPLC methods using Quality by Design approach are in the limelight of current research trends. A new, experimental design-aided HPLC method for fampridine was developed and preliminarily validated according to current in-force international guidelines for linearity, accuracy, robustness and precision. The method offers a high throughput sample analysis, with an elution time of 2. Read More

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http://dx.doi.org/10.2478/acph-2020-0036DOI Listing
December 2020

Anthelmintic activity of praziquantel and Spilanthes acmella extract on an intestinal cestode parasite.

Acta Pharm 2020 Dec;70(4):551-560

Department of Life Sciences, Pachhunga University College Aizawl796001, Mizoram,India.

Spilanthes acmella Murr., popularised as toothache plant, is a well-known culinary and medicinal plant for different purposes, but its use as an anthelmintic is apparently exclusive to the Mizo people of India and Myanmar. A chloroform extract of Spilanthes acmella Murr. Read More

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http://dx.doi.org/10.2478/acph-2020-0039DOI Listing
December 2020

Piperazine derivatives as dangerous abused compounds.

Acta Pharm 2020 Dec;70(4):423-441

Department of Toxicology Faculty of Pharmacy, Collegium Medicum Nicolaus Copernicus University Bydgoszcz, Poland.

Piperazine derivatives are a group of compounds with a psychostimulant effect. They are an alternative to illegal drugs. They are being searched for recreational use due to their psychoactive and hallucinogenic effects. Read More

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http://dx.doi.org/10.2478/acph-2020-0035DOI Listing
December 2020

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing.

Acta Pharm 2020 Dec;70(4):443-463

Krka, d.d. Novo mesto, 8501 Novo mesto,Slovenia.

This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. Read More

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http://dx.doi.org/10.2478/acph-2020-0038DOI Listing
December 2020

Advanced flow cell design for in vitro release testing of mucoadhesive buccal films.

Acta Pharm 2020 Sep;70(3):359-371

University of Ljubljana, Faculty of Pharmacy, Chair of Pharmaceutical Technology, 1000 Ljubljana, Slovenia.

Films for buccal application are a slowly emerging new platform for drug delivery. There remains a lack of analytical techniques for the determination of in vitro active pharmaceutical ingredient release. The aim here was to develop an alternative method to the commonly used United States Pharmacopoeia (USP) 2 method, based on the flow-through cell. Read More

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http://dx.doi.org/10.2478/acph-2020-0030DOI Listing
September 2020

Synthesis, in vitro safety and antioxidant activity of new pyrrole hydrazones.

Acta Pharm 2020 Sep;70(3):303-324

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University Sofia 1000 Sofia, Bulgaria.

Six new N-pyrrolylhydrazide hydrazones were synthesized under micro synthesis conditions, assuring about 59-93 % yield, low harmful emissions and reagent economy. The structures of the new compounds were elucidated by melting points, TLC characteristics, IR, 1H and 13C NMR spectral data followed by MS data. The purity of the obtained compounds was proven by the corresponding elemental analyses. Read More

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http://dx.doi.org/10.2478/acph-2020-0026DOI Listing
September 2020

Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway.

Acta Pharm 2020 Sep;70(3):399-409

Department of Intensive Care Unit Shengli Oilfield Central Hospital Dongying, People's Republic of China.

Curcumin has been proved to inhibit cell proliferation and induce cell apoptosis in non-small cell lung cancer (NSCLC). However, little is known about antimetastatic effects and molecular mechanisms of curcumin in NSCLC. In this study, we investigated the involvement of miR-206 in curcumin's anti-invasion and anti-migration in NSCLC. Read More

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http://dx.doi.org/10.2478/acph-2020-0029DOI Listing
September 2020

Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats.

Acta Pharm 2020 Sep;70(3):387-397

Laboratorio de Neurofarmacología Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, Veracruz, México.

The aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 μmol kg-1 on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structure that is involved in the regulation of anxiety, in male Wistar rats. These effects were compared with the clinically effective anxiolytic diazepam 7 μmol kg-1. The results showed that acute, but not chronic treatment, with 4 μmol kg-1 chrysin exerted anxiolytic- and anti- depressant-like effects with these effects being similar to that of diazepam. Read More

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http://dx.doi.org/10.2478/acph-2020-0022DOI Listing
September 2020

Simultaneous determination of warfarin and 7-hydroxywarfarin in rat plasma by HPLC-FLD.

Acta Pharm 2020 Sep;70(3):343-357

Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.

In this study, high-performance liquid chromatography with fluorescence detection (HPLC-FLD) has been used for the first time, for direct determination of warfarin and its major metabolite, 7-hydroxywarfarin, in rat plasma. The simple and sensitive method was developed using Fortis® reversed-phase diphenyl column (150 × 4.6 mm, 3 μm) and a mobile phase composed of phosphate buffer (25 mmol L-1)/methanol/acetonitrile (70:20:10, V/V/V), adjusted to pH 7. Read More

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http://dx.doi.org/10.2478/acph-2020-0025DOI Listing
September 2020

Preparation, characterization, and in vivo pharmacokinetics of thermosensitive in situ nasal gel of donepezil hydrochloride.

Acta Pharm 2020 Sep;70(3):411-422

Affiliated Hospital,Inner Mongolia Medical University, Hohhot 010050 China.

Donepezil hydrochloride thermosensitive in situ gel for nasal delivery was prepared by using Poloxamer 407 and Poloxamer 188 as thermoreversible polymers, hydroxypropyl-β-cyclodextrin and ethylparaben as permeation enhancer and preservative, respectively. The gelation temperature and time, pH value of the gel formulation were found to meet the requirements for nasal administration. The in vitro erosion and in vitro release tests exhibited obvious drug sustained release behavior. Read More

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http://dx.doi.org/10.2478/acph-2020-0032DOI Listing
September 2020

Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS.

Acta Pharm 2020 Sep;70(3):325-342

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

The aim of this study was to investigate the stability of three major antioxidants of Nigella sativa: thymoquinone (TQ), carvacrol (CR) and thymol (THY), under different stress conditions using HPLC and LC-MS/MS. Forced degradation for each compound was performed under different conditions, including oxidation, hydrolysis, photolysis and thermal decomposition. The results showed that both CR and THY were stable under the studied conditions, whereas TQ was not affected by acidic, basic and oxidative forced conditions but the effect of light and heat was significant. Read More

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http://dx.doi.org/10.2478/acph-2020-0028DOI Listing
September 2020

Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges.

Acta Pharm 2020 Sep;70(3):291-301

Department of Cancer Genetics with Cytogenetics Laboratory, Medical University of Lublin, 20-080 Lublin Poland.

Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. First of all, they act as histone deacetylase (HDAC) inhibitors (HDIs), being involved in the epigenetic regulation of gene expression. Afterward, VPA is shown to induce apoptosis and cell differentiation, as well as regulate Notch signaling. Read More

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http://dx.doi.org/10.2478/acph-2020-0021DOI Listing
September 2020

2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses.

Authors:
Georgeta Serban

Acta Pharm 2020 Sep;70(3):259-290

Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea410028Oradea, Romania.

Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. Read More

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http://dx.doi.org/10.2478/acph-2020-0031DOI Listing
September 2020

Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride.

Acta Pharm 2020 Sep;70(3):373-385

Department of Chemistry Faculty of Science, Yarmouk UniversityP.O. Box 560,Irbid22163,Jordan.

Green and sensitive spectrofluorometric methods have been developed and validated for the determination of timolol maleate (TML)/hydrochlorothiazide (HCT) and amiloride hydrochloride (AMH)/hydrochlorothiazide in tablets. The proposed spectrofluorometric procedures were found to be linear in the range of 4-12, 5-35 and 0.025-0. Read More

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http://dx.doi.org/10.2478/acph-2020-0027DOI Listing
September 2020

Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells.

Acta Pharm 2020 Jun;70(2):179-190

Department of Pharmaceutical Sciences, School of Pharmacy University of Jordan, Amman 11942 Jordan.

Breast cancer is the most common cancer and is the leading cause of cancer deaths among women worldwide. Despite the availability of numerous therapeutics for breast cancer management, cytotoxicity and emergence of drug resistance are major challenges that limit their benefits. The acidic microenvironment surrounding tumor cells is a common feature inducing cancer cell invasiveness and chemoresistance. Read More

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http://dx.doi.org/10.2478/acph-2020-0020DOI Listing

Effects of new generation triptans - frovatriptan and almotriptan - on hemodynamic parameters in intact male and female rats.

Acta Pharm 2020 Jun;70(2):239-247

Laboratory of Neuropharmacology, Technological Center of Emergency Medicine (TCEMED), Plovdiv, Bulgaria.

The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses not only the typical 5-HT1B/1D receptor agonist activity, but shows an affinity to the 5-HT1F receptor. The aim of our study was to assess the impact of frovatriptan and almotriptan on hemodynamics in male and female rats. Read More

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http://dx.doi.org/10.2478/acph-2020-0005DOI Listing

Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves.

Acta Pharm 2020 Jun;70(2):215-226

Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka410001 Enugu State,Nigeria.

Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves. Read More

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http://dx.doi.org/10.2478/acph-2020-0019DOI Listing

Synthesis of bioactive quinazolin-4(3H)-one derivatives via microwave activation tailored by phase-transfer catalysis.

Acta Pharm 2020 Jun;70(2):161-178

Medical Laboratory Technology, Department, College of Applied Medical Sciences, Taibah University, Madinah 30001Kingdom of Saudi Arabia.

A series of nine new 2,3-disubstituted 4(3H)-quinazolin-4-one derivatives was furnished starting from the 2-propyl-4(3H)-quinazo-line-4-one (2). The reinvestigation of the key starting quinazolinone 2 was performed under microwave irradiation (MW) and solvent-free conditions. Combination of MW and phase-transfer catalysis using tetrabutylammonium benzoate (TBAB) as a novel neutral ionic catalyst was used for carrying out N-alkylation and condensation reactions of compound 2 as a simple, efficient and eco-friendly technique. Read More

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http://dx.doi.org/10.2478/acph-2020-0001DOI Listing

Application of targeted 2D planar chromatography in the control of ginkgolic acids in some herbal drugs and dietary supplements.

Acta Pharm 2020 Jun;70(2):201-213

Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk 80-416 Gdańsk, Poland.

Two-step targeted 2D planar chromatographic method (2DTLC) was used in the determination of ginkgolic acids in pharmaceuticals and dietary supplements. The choice of the extraction method and the separation technique was guided by the formulation type (capsule, tablet, tincture) with expected low amounts of ginkgolic acids in the analyzed herbal samples. Separation of ginkgolic acids C15:1 and C17:1 on HPTLC RP18 WF254s was preceded by its separation from the sample matrix on TLC Si60 F254s. Read More

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http://dx.doi.org/10.2478/acph-2020-0004DOI Listing

Maternal education, health profession and cigarette smoking are decisive factors for self-medication in children by parents.

Acta Pharm 2020 Jun;70(2):249-257

Medical Faculty of the University of Montenegro, Department of Medical Ethics Podgorica, Montenegro.

Self-medication of children by their parents (SMCP) is an important public health issue as the effects and potential risks may be unpredictable. The objective of this first national Montenegrin study was to assess the prevalence of and factors influencing SMCP among schoolchildren. Data were obtained from a national representative sample of 4496 schoolchildren aged 7-13 years (50. Read More

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http://dx.doi.org/10.2478/acph-2020-0018DOI Listing

Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway.

Acta Pharm 2020 Jun;70(2):227-237

Institute of Drug Metabolism, School of Pharmaceutical Sciences, Anhui University of Chinese Medicine, Hefei 230012, Anhui,China.

Curcumin is a lipophilic anti-cancer compound extracted from turmeric. Our previous study demonstrated that the curcumin-loaded nanostructured lipid carrier (Cur-NLC) exhibits superior anti-cancer activity in inhibiting proliferation as well as inducing apoptosis of human HepG2 cells compared to native curcumin. This study aims to unveil the mechanisms underlying the pro-apoptotic effect of Cur-NLC on HepG2 cells. Read More

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http://dx.doi.org/10.2478/acph-2020-0003DOI Listing

SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1.

Acta Pharm 2020 Jun;70(2):191-200

Department of Urologic Surgery, Ningbo Yinzhou Second Hospital, Ningbo 315100, China.

The incidence of mortality of prostate cancer (PCa) has been an uptrend in recent years. Our previous study showed that the sex-determining region Y-box 7 (SOX7) was low-expressed and served as a tumor suppressor in PCa cells. Here, we describe the effects of polyphyllin D (PD) on proliferation and cell cycle modifications of PCa cells, and whether SOX7 participates in this process. Read More

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http://dx.doi.org/10.2478/acph-2020-0017DOI Listing

Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way.

Acta Pharm 2020 Jun;70(2):131-144

Lek d.d., 1526Ljubljana, Slovenia.

The biopharmaceutical classification of drugs was designed as a basis for bio-waivers - a mechanism with the double ethical benefit of delivering new drug formulations to the market with less human testing and lower cost. However, many drugs defy simple classification because in vitro permeability and stability assessment can be challenging as shown in this study for desloratadine. Literature shows that desloratadine is highly soluble, while data on luminal stability and permeability are circumstantial. Read More

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http://dx.doi.org/10.2478/acph-2020-0006DOI Listing

Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors.

Acta Pharm 2020 Jun;70(2):145-159

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University Alhasa, Kingdom of Saudi Arabia.

Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. Read More

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http://dx.doi.org/10.2478/acph-2020-0024DOI Listing

Qualitative and quantitative HPLC-ELSD-ESI-MS analysis of steroidal saponins in fenugreek seed.

Acta Pharm 2020 Mar;70(1):89-99

Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Gdańsk, 80-416 Gdańsk, Poland.

Fenugreek seeds are known as a source of various compounds, the most common of which are steroidal saponins. However, despite the growing interest in this plant material as a healing agent, spice and dietary supplement ingredient, the composition of Polish fenugreek seeds remains unknown. Therefore, the steroidal saponin complex in the seeds of T. Read More

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http://dx.doi.org/10.2478/acph-2020-0013DOI Listing

Beneficial effects of baicalein on a model of allergic rhinitis.

Acta Pharm 2020 Mar;70(1):35-47

School of Clinical Medicine, Jining Medical University, Jining, Shandong,China.

Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. Read More

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http://dx.doi.org/10.2478/acph-2020-0009DOI Listing
March 2020
1.025 Impact Factor

Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats.

Acta Pharm 2020 Mar;70(1):121-127

Laboratory of Pharmacology, INP Mexico.

The aim of the present study was to determine the effect of sildenafil on dopamine, 5-hydroxyindol acetic acid (5-HIAA) and selected biomarkers of oxidative stress in the brain of hypoglycemic rats. The animals were treated intraperitoneally as follows: group 1 (control), saline solution; group 2, insulin (10 U per rat or 50 U kg-1); group 3, insulin + single dose of sildenafil (50 U kg-1 + 50 mg kg-1); group 4, insulin + three doses of sildenafil every 24 hours (50 U kg-1 + 50 mg kg-1). In groups 2, 3 and 4, insulin was administered every 24 hours for 10 days. Read More

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http://dx.doi.org/10.2478/acph-2020-0016DOI Listing
March 2020
1 Read

Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin.

Acta Pharm 2020 Mar;70(1):77-88

School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80161,Thailand.

The aim of the present study was to develop self-microemulsifying drug delivery systems (SMEDDS) of the extract of Moringa oleifera, a herbal medicinal plant. Kaempferol and quercetin, the flavonoids present in the leaf extract of M. oleifera, were chosen as markers for quantification. Read More

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http://dx.doi.org/10.2478/acph-2020-0012DOI Listing

Development and validation of a UPLC-MS method for determination of atazanavir sulfate by the "analytical quality by design" approach.

Acta Pharm 2020 Mar;70(1):17-33

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka570015 India.

A UPLC-MS method for the estimation of atazanavir sulfate was developed using the "analytical quality by design" approach. The critical chromatographic quality attributes identified were retention time, theoretical plates and peak tailing. The critical method parameters established were percent of organic modifier, flow rate and injection volume. Read More

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http://dx.doi.org/10.2478/acph-2020-0008DOI Listing

Branched PLGA derivatives with tailored drug delivery properties.

Acta Pharm 2020 Mar;70(1):63-75

Charles University, Faculty of Pharmacy, 500 05 Hradec KraloveCzech Republic.

Despite several shortcomings such as extreme hydrophobicity, low drug capacity, characteristic triphasic drug release pattern with a high burst effect, poly(lactic-co-glycolic acid derivatives are widely used in drug delivery. Most frequent attempts to improve their properties are blending with other polymers or synthesis of block copolymers. We introduce a new class of branched poly(lactic-co-glycolic acid) derivatives as promising biodegradable carriers for prolonged or targeted drug release systems, employed as thin adhesive films, solid dispersions, in situ forming implants or nanoparticles. Read More

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http://dx.doi.org/10.2478/acph-2020-0011DOI Listing

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering.

Acta Pharm 2020 Mar;70(1):1-15

University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory for Separation Processes, Maribor, Slovenia.

Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physico-chemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Read More

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http://dx.doi.org/10.2478/acph-2020-0007DOI Listing

TLC-densitometric analysis of allantoin in Symphytum officinale L. roots.

Acta Pharm 2020 Mar;70(1):101-110

Medical University of Gdańsk, Department of Pharmacognosy with the Medicinal Plants Garden, Gdańsk, Poland.

A TLC-densitometric method for determination of allantoin in Symphytum officinale root was developed. Densitometric quantification of allantoin was carried out on TLC Si60 plates with butanol-50 % methanol/formic acid, 66.5:33. Read More

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http://dx.doi.org/10.2478/acph-2020-0014DOI Listing

Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets.

Acta Pharm 2020 Mar;70(1):49-61

Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens.

Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide's longer gastric retention and waste minimization by preparing matrix and compression coated tablets incorporating different grades of Eudragit® and poly(ethylene oxide) (PEO), polyvinylpyrrolidone (PVP) and lactose monohydrate. Dissolution profiles of the new formulations were compared with that of the main stream drug Lasix®, 40 mg tablets. Read More

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http://dx.doi.org/10.2478/acph-2020-0010DOI Listing
March 2020
1.025 Impact Factor

Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres.

Acta Pharm 2019 Dec;69(4):635-648

University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Zagreb Croatia.

The aim of this study was to evaluate long-term stability and assess the wound healing potential of the innovative melatonin-loaded lipid-enriched hybrid system compared to conventional melatonin-loaded chitosan microspheres. The hybrid system contained nanostructured lipid carrier incorporated in the chitosan matrix, in order to modify melatonin release and alter physicochemical characteristics of the delivery system. Stability testing was performed during a six-month period under two conditions: refrigerated (5 ± 3 °C) and at room temperature (25 ± 2 °C/60 ± 5 % RH). Read More

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http://dx.doi.org/10.2478/acph-2019-0049DOI Listing
December 2019
4 Reads
1.025 Impact Factor

Evaluation of phenylethylamine type entactogens and their metabolites relevant to ecotoxicology - a QSAR study.

Acta Pharm 2019 Dec;69(4):563-584

University of Zagreb, Faculty of Chemical Engineering and Technology 10000 Zagreb, Croatia.

The impact of the selected entactogens and their o-quinone metabolites on the environment was explored in QSAR studies by the use of predicted molecular descriptors, ADMET properties and environmental toxicity parameters, i.e., acute toxicity in Tetrahymena pyriformis (TOX_ATTP) expressed as Th_pyr_pIGC50/mmol L-1, acute toxicity in Pimephales promelas, the fathead minnow (TOX_FHM) expressed as Minnow LC50/mg L-1, the acute toxicity in Daphnia magna (TOX_DM) expressed as Daphnia LC50/mg L-1 and bioconcentration factor (BCF). Read More

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http://dx.doi.org/10.2478/acph-2019-0038DOI Listing
December 2019
1 Read

Application of medicinal plants in several dermatovenerological entities.

Acta Pharm 2019 Dec;69(4):525-531

Private Dermatology and Venereology Clinic "Dr. Nada Videnić" 47000 Karlovac, Croatia.

Treatment of skin conditions with medicinal plants has been an ongoing human activity lasting over thousands of years. The use of specific plant species developed regionally, based on local flora. Commonly used medicinal plants for dermatological complaints are: Phlebodium aureum (L. Read More

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http://dx.doi.org/10.2478/acph-2019-0045DOI Listing
December 2019
1 Read

Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs.

Acta Pharm 2019 Dec;69(4):461-482

University of Zagreb, Faculty of Pharmacy and Biochemistry 10000 Zagreb, Croatia.

Cancer presents one of the leading causes of death in the world. Current treatment includes the administration of one or more anticancer drugs, commonly known as chemotherapy. The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. Read More

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http://dx.doi.org/10.2478/acph-2019-0052DOI Listing
December 2019

Antiproliferative evaluation of various aminoquinoline derivatives.

Acta Pharm 2019 Dec;69(4):661-672

University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.

Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a-f, primaquine bis-ureas 2a-f, chloroquine fumardiamides 3a-f and mefloquine fumardiamides 4a-f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines. Read More

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http://dx.doi.org/10.2478/acph-2019-0048DOI Listing
December 2019
1 Read

Phenolic compounds of Iris adriatica and their antimycobacterial effects.

Acta Pharm 2019 Dec;69(4):673-681

University of Graz, Institute of Pharmaceutical Sciences, Department of Pharmacognosy, 8010 Graz Austria.

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc2 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L-1. Read More

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http://dx.doi.org/10.2478/acph-2019-0037DOI Listing
December 2019
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Implementation of medication management services at the primary healthcare level - a pilot study.

Acta Pharm 2019 Dec;69(4):585-606

Centre for Pharmaceutical Care Studies (Centro de Estudos Atencao Farmaceutica), Federal University of Minas Gerais Belo Horizonte, MG,Brazil.

This study employed a mixed-method approach to enable the implementation of comprehensive medication management (CMM) services in Croatia's primary care setting. Drug therapy problems (DTPs) and factors associated with their occurrence were determined in patients with chronic diseases from January 2018 to April 2019. The pre-implementation stage established the foundations for the early implementation stage, in which the practice was set up, the patients' recruitment initiated and various challenges identified. Read More

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http://dx.doi.org/10.2478/acph-2019-0055DOI Listing
December 2019

Antiproliferative and genotoxic potential of xanthen-3-one derivatives.

Acta Pharm 2019 Dec;69(4):683-694

University of Sarajevo, Faculty of Pharmacy, 71000 Sarajevo, Bosnia and Herzegovina.

Twelve previously synthesized, biologically active 2,6,7-trihydroxyxanthen-3-one derivatives were evaluated in vitro for antiproliferative activity. Compounds were screened against HeLa, SW620, HepG2 and A549 tumor cell lines. Compound with the trifluormethyl group on C-4' position of the phenyl ring showed the best inhibitory activity towards HeLa and A549 tumor cells with IC50 of 0. Read More

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http://dx.doi.org/10.2478/acph-2019-0044DOI Listing
December 2019
1.025 Impact Factor

Nutrition - facts and myths.

Acta Pharm 2019 Dec;69(4):497-510

University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medical Biochemistry and Hematology, HR-10000 Zagreb, Croatia.

Taking responsibility for your life, among other factors, means also considering what to eat and which nutrition pattern to follow. Everyone needs to think about what they put on the plate and which ingredients should be avoided. Food, as such, will never be a drug or medication, like a painkilling tablet relieving pain in a short amount of time, for example. Read More

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http://dx.doi.org/10.2478/acph-2019-0051DOI Listing
December 2019

A modern approach to the treatment of plaque psoriasis.

Acta Pharm 2019 Dec;69(4):511-523

Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, HR-10000 Zagreb, Croatia.

Psoriasis is a common chronic inflammatory skin disease which affects 0.5-1 % of children and 2-3 % of the adult population. In Croatia, 1. Read More

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http://dx.doi.org/10.2478/acph-2019-0047DOI Listing
December 2019

Influence of flavonoids' lipophilicity on platelet aggregation.

Acta Pharm 2019 Dec;69(4):607-619

Croatian Institute of Transfusion Medicine, HR-10000 Zagreb, Croatia.

Flavonoids are natural polyphenolic compounds present in a wide spectrum of plants that have a beneficial effect on human health. In the context of cardiovascular diseases related to plaque and thrombus formation, flavonoids exhibit an anti-aggregatory effect. Previously, it has been reported that all tested flavonoids exhibit an antiaggregatory effect on platelet aggregation when measured by impedance aggregometry on whole blood, in the test of aggregation induced by adenosine diphosphate (ADP). Read More

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http://dx.doi.org/10.2478/acph-2019-0040DOI Listing
December 2019