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Acta Cytol 2020 Jun 4:1-5. Epub 2020 Jun 4.

Clinical Cytopathology Service, Histopathology Service, Istituto Cantonale di Patologia, Locarno, Switzerland,

In this article, we report on a case of combined, acinar and ductal prostatic adenocarcinoma affecting the prostatic urethra, which, due to a low degree of cytologic atypia and an exclusive papillary architecture with visible fibrovascular core, was erroneously diagnosed as a low-grade urothelial carcinoma based on its peculiar cytologic presentation in a bladder washing sample. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 29;239:118530. Epub 2020 May 29.

Saint Louis University, Chemistry Department, 3501 Laclede Ave., 63103 Saint Louis, MO, United States. Electronic address:

Hemoglobin (Hb) is a key component of respiratory system and as such plays important role in human physiology. The studies of Hb's structure and functions are usually performed on cell-free protein; however, it has been shown that there are functionally relevant differences between isolated Hb and Hb present inside red blood cells (RBCs). It is clear that new experimental approaches are needed to understand the origin of these differences and to gain insight into the structure-function relationship of Hb within intact living cells. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2020 May 26;239:118531. Epub 2020 May 26.

College of Chemistry, Nanchang University, Nanchang 330031, China.

Adenine-stabilized carbon dots (A-CDs) are shown to be a viable fluorescent probe for highly sensitive detection and imaging of Cu. The probe has a linear fluorometric response in the 1-700 nM concentration range and a 0.3 nM detection limit. Read More

Acta Biomater 2020 Jun 1. Epub 2020 Jun 1.

Joint Department of Biomedical Engineering. University of North Carolina - Chapel Hill and North Carolina State University - Raleigh. 1840 Entrepreneur Drive. Raleigh, NC 27695, USA. Electronic address:

Injectable alginate hydrogels have demonstrated utility in tissue engineering and drug delivery applications due in part to their mild gelation conditions, low host responses and chemical versatility. Recently, the potential of these gels has expanded with the introduction of refillable hydrogel depots - alginate gels chemically decorated with click chemistry groups to efficiently capture prodrug refills from the blood. Unfortunately, high degrees of click group substitution on alginate lead to poor viscoelastic properties and loss of ionic cross-linking. Read More

Acta Biomater 2020 Jun 1. Epub 2020 Jun 1.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15219; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15260; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15260. Electronic address:

Bone loss due to trauma and tumors remains a serious clinical concern. Due to limited availability and disease transmission risk with autografts and allografts, calcium phosphate bone fillers and growth factor-based substitute bone grafts are currently used in the clinic. However, substitute grafts lack bone regeneration potential when used without growth factors. Read More

Acta Psychol (Amst) 2020 Jun 1;208:103088. Epub 2020 Jun 1.

Department of Psychology, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom. Electronic address:

People find positive attribute frames (e.g., 75% lean) more persuasive than negative ones (e. Read More

Acta Psychol (Amst) 2020 Jun 1;208:103081. Epub 2020 Jun 1.

Department of Psychology, Princeton University, Princeton, NJ 08540, USA; Department of Psychology, New York University, 6 Washington Place, New York, NY 10003, USA.

Reasoning about epistemic possibilities - those based on knowledge - is fundamental in daily life. It is formalized in modal logics, of which there are infinitely many, based on the semantics of 'possible worlds'. An alternative psychological theory postulates that possibilities (and probabilities) in daily life are based on the human ability to construct mental models of finite alternatives, which can each be realized in an indefinite number of different ways. Read More

Biochim Biophys Acta Proteins Proteom 2020 Jun 1:140464. Epub 2020 Jun 1.

Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Nakano, Tokyo 164-8530, Japan; Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:

The residual solution structures of two alpha-synuclein mutants, A30P and A53T, observed in family members of patients with Parkinson's disease were compared with that of wild-type by NMR. The A53T substitution had been shown to accelerate fibril formation of alpha-synuclein, whereas the A30P mutation has the negative and positive effects on the formation of the fibril and spherical oligomer, respectively. The remaining structure was analyzed via amide-proton exchange and signal intensity measurements using NMR. Read More

Biochim Biophys Acta Mol Basis Dis 2020 Jun 1:165850. Epub 2020 Jun 1.

Department of Physiology, College of Medicine (QU Health), Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:

Abnormal wound healing with excessive scarring is a major health problem with socioeconomic and psychological impacts. In human, chronic wounds and scarring are associated with upregulation of the inducible nitric oxide synthase (iNOS). Recently, we have shown physiological regulation of iNOS in wound healing. Read More

Biochim Biophys Acta Biomembr 2020 Jun 1:183380. Epub 2020 Jun 1.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences RAS, str. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation. Electronic address:

Latent membrane protein 1 (LMP1) is a gene product of the Epstein-Barr virus (EBV), a widely spread virus present in 90-95% of the world's population. EBV can lead to several malignancies, in which LMP1 was shown to play a key role. LMP1 is active only in the oligomeric form and its fifth transmembrane domain (TMD-5) is critical for the oligomerization, with D150 identified as a key residue for LMP1 activation. Read More

Acta Trop 2020 Jun 1:105532. Epub 2020 Jun 1.

Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok, 10900, Thailand.

Chrysops spp. or deer flies (Diptera: Tabanidae) are hematophagous flies of medical and veterinary importance and some species are important vectors of Trypanosoma evansi, the causative agent of surra in Thailand. However, data regarding deer fly species and their molecular identification are limited. Read More

Acta Physiol (Oxf) 2020 Jun 4:e13520. Epub 2020 Jun 4.

Universitätsklinikum Jena, KIM III, Experimentelle Nephrologie, Jena, Germany.

The new coronavirus SARS-COV-2 is currently impacting life around the globe . The rapid spread of this viral disease might be highly challenging for health care systems. This was seen in Northern Italy and in New York City for example . Read More

Acta Paediatr 2020 Jun 4. Epub 2020 Jun 4.

Department of Paediatrics, Tergooi Hospital, Blaricum, The Netherlands.

Suspected early-onset sepsis (EOS) remains a significant challenge for clinicians and often requires a balance between efficient sepsis care and antimicrobial stewardship. Low EOS incidence rates and widespread antibiotic use cause widespread overtreatment. Strategies for identifying high-risk neonates include categorical risk factor assessments, multivariate risk assessments and risk assessments primarily based on the infants' clinical condition. Read More

Acta Neurol Scand 2020 Jun 4. Epub 2020 Jun 4.

Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, P.R. China.

Introduction: Guillain-Barré syndrome (GBS) is one of the most common causes of acute flaccid paralysis, with up to 20-30% of patients requiring mechanical ventilation. The aim of our study was to develop and validate a mechanical ventilation risk nomogram in a Chinese population of patients with GBS.

Methods: A total of 312 GBS patients were recruited from January 1, 2015 to June 31, 2018, of whom 17% received mechanical ventilation. Read More

Acta Chir Belg 2020 Jun 4:1-18. Epub 2020 Jun 4.

Liver Transplant Institute, Inonu University, 44280, Malatya, Turkey.

To share our experience with hollow viscus migration of artificial vascular grafts (AVG) used for venous reconstruction of the right anterior sector in living donor liver transplantations (LDLT). Clinical, radiological, and endoscopic data of 13 right lobe LDLT patients (range: 26-67 years) with a diagnosis of postoperative AVG migration into adjacent hollow viscus were analyzed.: Biliary complications were detected in 12 patients. Read More

Acta Chir Belg 2020 Jun 4:1-18. Epub 2020 Jun 4.

Surgical-Oncosurgical Dept., Uzsoki Teaching Hospital, Budapest, Hungary.

Conventional abdominoperineal resection (APR) has a high rate of local recurrence. Extralevator abdominoperineal excision (ELAPE) can potentially diminish the rate of intraoperative tumour perforation (IOTP) and can provide wider circumferential resection margins (CRM) but at the price of higher perineal complication rate. The aim of our study was to compare the short term results of conventional APR to ELAPE. Read More

Acta Oncol 2020 Jun 4:1-5. Epub 2020 Jun 4.

Radiation Oncology Department, Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

Radiation therapy (RT) has been widely used for palliation in multiple myeloma. However, no data exist on symptom assessment and patient-reported outcomes regarding the efficacy of RT in this disease process. This study aims to demonstrate the impact of palliative RT on patient-reported symptoms in patients with multiple myeloma. Read More

Acta Orthop 2020 Jun 4:1-5. Epub 2020 Jun 4.

Luxembourg Institute of Health, Human Motion, Orthopedics, Sports Medicine, Digital Methods (HOSD), Luxembourg, Luxembourg.

Background and purpose - Hip resurfacing arthroplasty (HRA) was designed for the highly active patient because of the various theoretical advantages compared with stemmed total hip arthroplasty (THA), but has shown high failure rates. Physical activity (PA) after arthroplasty is frequently determined with the use of questionnaires, which are known for their subjective nature, recall bias, and ceiling effect. These disadvantages are not applicable to physical activity monitoring (AM) using sensors. Read More

Acta Paediatr 2020 Jun 4. Epub 2020 Jun 4.

Department of General Pediatrics & Neonatology, Justus Liebig University and Universities of Giessen and Marburg Lung Center (UGMLC), Germany.

We thank for the opportunity to respond to the letter of Dr. Al-Abdi (1) concerning our manuscript "Preeclampsia was a risk factor for pulmonary interstitial emphysema (PIE) in preterm infants born ≤ 32 weeks of gestational age" (2). We like to comment on the chronology and scientific facts. Read More

Acta Paediatr 2020 Jun 4. Epub 2020 Jun 4.

Department of Child Psychiatry, University of Turku, Finland.

Aim: To assess whether relative age was associated with bullying involvement and whether the associations were independent of child psychiatric symptoms.

Methods: Bullying was assessed among 8576 children in the second grade, aged 8 years, by using four cross-sectional population-based studies with identical methodology completed by children, parents and teachers in 1989 (response rate 97%), 1999 (93%), 2005 (90%), and 2013 (86%). The main outcomes were bullying victimization and perpetration. Read More

Acta Paediatr 2020 Jun 4. Epub 2020 Jun 4.

Department of Pediatrics, King Abdulaziz Hospital, Ministry of the National Guard-Health Affairs, Al-Ahsa, Saudi Arabia, King Abdullah International Medical Research Center, Al-Ahsa, Saudi Arabia.

Sir, I read with deep sorrow the article "Preeclampsia was a risk factor for pulmonary interstitial emphysema in preterm infants born ≤ 32 weeks of gestational age" by Behnke et al. (1). In October 2005, we have published a case report "Pulmonary interstitial emphysema and continuous positive airway pressure in a premature infant" (2). Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):608-611. Epub 2020 May 29.

Global Phasing Ltd, Sheraton House, Castle Park, Cambridge CB3 0AX, United Kingdom.

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):594-607. Epub 2020 May 29.

Molecular Biophysics Group, Institute of Systems, Molecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom.

Methionine adenosyltransferase (MAT) deficiency, characterized by isolated persistent hypermethioninemia (IPH), is caused by mutations in the MAT1A gene encoding MATαl, one of the major hepatic enzymes. Most of the associated hypermethioninemic conditions are inherited as autosomal recessive traits; however, dominant inheritance of hypermethioninemia is caused by an Arg264His (R264H) mutation. This mutation has been confirmed in a screening programme of newborns as the most common mutation in babies with IPH. Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):581-593. Epub 2020 May 29.

Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956 Istanbul, Turkey.

PATZ1 is a ubiquitously expressed transcriptional repressor belonging to the ZBTB family that is functionally expressed in T lymphocytes. PATZ1 targets the CD8 gene in lymphocyte development and interacts with the p53 protein to control genes that are important in proliferation and in the DNA-damage response. PATZ1 exerts its activity through an N-terminal BTB domain that mediates dimerization and co-repressor interactions and a C-terminal zinc-finger motif-containing domain that mediates DNA binding. Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):565-580. Epub 2020 May 29.

Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, United Kingdom.

The lysosomal glycoside hydrolase β-glucocerebrosidase (GBA; sometimes called GBA1 or GC) catalyses the hydrolysis of glycosphingolipids. Inherited deficiencies in GBA cause the lysosomal storage disorder Gaucher disease (GD). Consequently, GBA is of considerable medical interest, with continuous advances in the development of inhibitors, chaperones and activity-based probes. Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):558-564. Epub 2020 May 29.

Department of Biotechnology, Chemistry and Pharmacy - Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

The protozoan parasite Trypanosoma brucei is the etiological agent of human African trypanosomiasis (HAT). HAT, together with other neglected tropical diseases, causes serious health and economic issues, especially in tropical and subtropical areas. The classical antifolates targeting dihydrofolate reductase (DHFR) are ineffective towards trypanosomatid parasites owing to a metabolic bypass by the expression of pteridine reductase 1 (PTR1). Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):542-557. Epub 2020 May 29.

Department of Chemistry and Physics, DeSales University, 2755 Station Avenue, Center Valley, PA 18034, USA.

Archaea are uniquely adapted to thrive in harsh environments, and one of these adaptations involves the archaeal membrane lipids, which are characterized by their isoprenoid alkyl chains connected via ether linkages to glycerol 1-phosphate. The membrane lipids of the thermophilic and acidophilic euryarchaeota Thermoplasma volcanium are exclusively glycerol dibiphytanyl glycerol tetraethers. The first committed step in the biosynthetic pathway of these archaeal lipids is the formation of the ether linkage between glycerol 1-phosphate and geranylgeranyl diphosphate, and is catalyzed by the enzyme geranylgeranylglyceryl phosphate synthase (GGGPS). Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):531-541. Epub 2020 May 29.

York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.

This work focuses on the use of the existing protein-model-building software Buccaneer to provide structural interpretation of electron cryo-microscopy (cryo-EM) maps. Originally developed for application to X-ray crystallography, the necessary steps to optimise the usage of Buccaneer with cryo-EM maps are shown. This approach has been applied to the data sets of 208 cryo-EM maps with resolutions of better than 4 Å. Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):521-530. Epub 2020 May 29.

Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka 565-0871, Japan.

Uridine diphosphate glycosyltransferases (UGTs) are ubiquitous enzymes that are involved in the glycosylation of small molecules. As glycosylation improves the water solubility and stability of hydrophobic compounds, interest in the use of UGTs for the synthesis of glycosides of poorly soluble compounds is increasing. While sugar-donor recognition in UGTs is conserved with the presence of a plant secondary product glycosyltransferase (PSPG) motif, the basis of the recognition of the sugar acceptor and the regioselectivity of the products is poorly understood owing to low sequence identity around the acceptor-binding region. Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):515-520. Epub 2020 May 29.

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

The N-terminal region of the stomatin operon partner protein (STOPP) PH1510 (1510-N) from the hyperthermophilic archaeon Pyrococcus horikoshii is a serine protease with a catalytic Ser-Lys dyad (Ser97 and Lys138) and specifically cleaves the C-terminal hydrophobic region of the p-stomatin PH1511. In a form of human hemolytic anemia known as hereditary stomatocytosis, stomatin is deficient in the erythrocyte membrane owing to mis-trafficking. Stomatin is thought to act as an oligomeric scaffolding protein to support cell membranes. Read More

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):506-514. Epub 2020 May 29.

Department of Microbiology, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

DcsB, one of the enzymes encoded in the D-cycloserine (D-CS) biosynthetic gene cluster, displays a high sequence homology to arginase, which contains two manganese ions in the active site. However, DcsB hydrolyzes N-hydroxy-L-arginine, but not L-arginine, to supply hydroxyurea for the biosynthesis of D-CS. Here, the crystal structure of DcsB was determined at a resolution of 1. Read More

Acta Paediatr 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland.

Aim: Interleukin-17F (IL-17F) is involved with asthma. The aim of this study was to evaluate the association of IL17F polymorphisms with childhood asthma after bronchiolitis in infancy.

Methods: We invited 166 children who were hospitalized for bronchiolitis at younger than 6 months of age to follow-up visits at 5-7 years and 11-13 years of ages. Read More

Acta Psychiatr Scand 2020 Jun 3. Epub 2020 Jun 3.

Leiden University Medical Center, Leiden, Netherlands.

Objective: To explore the potential efficacy of multi-modular motion-assisted memory desensitisation and reprocessing (3MDR) in British military veterans with treatment-resistant, service-related PTSD.

Methods: Exploratory single-blind, randomised, parallel arm, cross-over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome.

Results: 42 participants (all male) were randomised with 83% retention at 12 weeks and 86% at 26 weeks. Read More

Acta Neurochir (Wien) 2020 Jun 3. Epub 2020 Jun 3.

Pediatric Neurosurgery, Campus Virchow Klinikum, Charité, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: Hydrocephalus may present with heterogeneous signs and symptoms. The indication for its treatment and the optimal drainage in complex cases may be challenging. Telemetric intracranial pressure measurements (TICPM) may open new perspectives for those circumstances. Read More

Acta Neurochir (Wien) 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

Background: A shift in how we evaluate healthcare outcomes has driven the introduction of quality indicators as potential parameters to evaluate value-based healthcare delivery. So far, only few studies have been performed evaluating quality indicators in the context of neurosurgery, especially in the European region. The purpose of this study was to evaluate the 30-day readmission rate, identify reasons for readmission regarding the various neurosurgical diagnoses, and discuss the usefulness of this rate as a potential quality indicator. Read More

Mikrochim Acta 2020 Jun 3;187(6):368. Epub 2020 Jun 3.

State Key Laboratory of Animal Nutrition, and Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, 100193, China.

A high-affinity monoclonal antibody (mAb) has been prepared and separately a gold nanoparticle (AuNP)-based and a near-infrared (NIR) fluorescence-based lateral flow immunoassay (LFA) developed for determination of 5-hydroxyflunixin residue in raw milk. The AuNP and IRDye® 800CW were used to label anti-5-hydroxyflunixin mAb to form the AuNP-mAb and NIR dye-mAb conjugates, respectively. Quantitative determination of 5-hydroxyflunixin was achieved by imaging the optical or fluorescence intensity of the AuNP-mAb and NIR dye-mAb captured on the test line. Read More

Acta Parasitol 2020 Jun 3. Epub 2020 Jun 3.

Departamento de Biologia Animal, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, BR 465, Km 7, Seropédica, Rio de Janeiro, CEP 23890-000, Brazil.

Background: Coccidia are obligatory intracellular parasites with at least one intestinal phase in their life cycles, being Isospora Schneider, 1881 the main coccidian genus related to the order Passeriformes. However, there is no record of isosporans from the passerine family Tityridae, which is the family of the greenish schiffornis Schiffornis virescens (Lafresnaye, 1838).

Purpose: This study aimed to examine the faeces from a greenish schiffornis S. Read More

Acta Parasitol 2020 Jun 3. Epub 2020 Jun 3.

Musée National d'Histoire Naturelle, 2160, Luxembourg, Luxembourg.

Background: Cryptosporidium spp. are protozoan parasites that cause enteric infection in a wide range of mammals, including humans. The raccoon (Procyon lotor) is an invasive species in many parts of the world and studies have shown that they can be infected with Cryptosporidium spp. Read More

Mikrochim Acta 2020 Jun 3;187(6):367. Epub 2020 Jun 3.

Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, Henan, China.

The monodispersed mesoporous SiO@metal-organic framework (MSN@MIL-101(Fe)) composites were prepared by grafting MSN-NH onto MIL-101(Fe) particles with a solvothermal method. The adsorption ability of the composites was greatly improved compared to that of pristine MSNs or MIL-101(Fe) for phytohormones (Phys). The MSN@MIL-101(Fe) composites were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive spectrometer, and mapping analysis. Read More

Mikrochim Acta 2020 Jun 3;187(6):366. Epub 2020 Jun 3.

Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.

An ultrasonic-assisted dispersive solid-phase microextraction was developed by a multi-stimuli responsive molecularly imprinted polymer based on chain transfer agent-modified chitosan nanoparticles for enrichment and separation of trace capecitabine in a real sample. The synthesized particles were carefully characterized and it was found that a uniform pH-sensitive imprinted polymeric shell is obtained on the surface of FeO@chitosan core with enough saturation magnetization (29 emu g). Desirable adsorption capacity (91 mg g) and high imprinting factor (IF = 3. Read More

Acta Derm Venereol 2020 Jun 3. Epub 2020 Jun 3.

Centre for Population Health Sciences (CePHaS), Lee Kong Chian School of Medicine, Nanyang Technological University, 308232 Singapore, Singapore.

This study examined concordance between caregiver-reported and physician-rated estimates of severity of atopic dermatitis (AD) in paediatric patients and explored potential explanatory factors. Physician-reported severity of AD was retrieved from medical records, while caregiver-reported disease severity and sociodemographic data were obtained through a survey that also collected information on out-of-pocket expenses due to AD. There was 38. Read More

Acta Derm Venereol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, University Medical Center Groningen (UMCG), 9713 GZ Groningen, The Netherlands. E-mail:

There are straightforward guidelines for treatment of keratinocyte carcinoma (formerly known as non-melanoma skin cancer); however, there are no clear recommendations specifically for elderly patients. The aim of this review was to provide an overview of the current literature about the effect of patient characteristics, specifically life expectancy, frailty and comorbidity, on treatment decisions in elderly patients with keratinocyte carcinoma, by searching PubMed database. It was found that the literature is limited and based mostly on small retrospective studies. Read More

Acta Derm Venereol 2020 Jun 3. Epub 2020 Jun 3.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504, Japan. E-mail:

Acta Derm Venereol 2020 Jun 3. Epub 2020 Jun 3.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 36-1 Nishicho, Yonago, Tottori 683-8504, Japan. E-mail:

is missing (Short communication). Read More

Acta Derm Venereol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology, Kawasaki Medical School, 701-0192 Kurashiki, Japan.

Yonago Acta Med 2020 May 16;63(2):132-134. Epub 2020 Apr 16.

Department of Pathobiological Science and Technology, Graduate School of Medical Sciences, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.

Home oxygen therapy (HOT) is an important treatment for patients with chronic respiratory diseases. Recently, telemonitoring of HOT has been become available. In the present study, we examined whether telemonitoring of HOT could improve health-related quality of life (HRQOL). Read More

Yonago Acta Med 2020 May 22;63(2):127-131. Epub 2020 Apr 22.

Division of Orthopedic Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503 Japan.

Reconstruction of bone and soft-tissue defects in the forearm is a surgery that often proves unsuccessful. Free fibular osteocutaneous flaps are a useful material for reconstruction that enable simultaneous reconstruction of bone, skin, and soft tissues. However, in free fibular osteocutaneous flaps, the fibula, skin, and vascular pedicle are tightly bound together by the posterior intermuscular septum and the perforators that pass through the septum, giving the disadvantage of a low degree of freedom when setting these structures in place. Read More

Yonago Acta Med 2020 May 18;63(2):122-126. Epub 2020 Mar 18.

Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.

We present a very rare case of a laparoscopically-assisted repair of a small bowel perforation secondary to multiple metastases of undifferentiated pleomorphic sarcoma from the posterior mediastinum. A 46-year-old man presented with middle to upper abdominal pain during chemotherapy for lung metastases from undifferentiated pleomorphic sarcoma. Computed tomography revealed intra-abdominal free air, and emergency laparoscopy was performed. Read More

Yonago Acta Med 2020 May 18;63(2):115-121. Epub 2020 May 18.

Department of Nursing, Faculty of Health Sciences, Ankara Yildirim Beyazit University, Ankara, Turkey.

Background: The current literature shows that one of the alternative therapies used to control constipation is reflexology. This study was conducted to assess the effect of reflexology on the constipation status of elderly people.

Methods: This study was randomized clinical trial conducted from at the private nursing home in the Ankara Province. Read More