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Acta Trop 2022 May 15:106500. Epub 2022 May 15.

Post-graduate program in Parasitary Biology in the Amazon, Center of Biological and Health Sciences, State of Pará University, Belém, 66095-662, Brazil; Evandro Chagas Institute - IEC/SVS/MS, Department of Arbovirology and Hemorrhagic Fevers, Ananindeua, 67030-000, Brazil. Electronic address:

The genus Aedes (Diptera: Culicidae) includes species of great epidemiological relevance, particularly involved in transmission cycles of leading arboviruses in the Brazilian Amazon region, such as the Zika virus (ZIKV), Dengue virus (DENV), Yellow fever virus (YFV), and Chikungunya virus (CHIKV). We report here the first putatively complete sequencing of the mitochondrial genomes of Brazilian populations of the species Aedes albopictus, Aedes scapularis and Aedes serratus. The sequences obtained showed an average length of 14,947 bp, comprising 37 functional subunits, typical in animal mitochondria (13 PCGs, 22 tRNA, and 2 rRNA). Read More

Acta Trop 2022 May 15:106519. Epub 2022 May 15.

National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention (Chinese Center for Tropical Diseases Research); National Health Commission of the People's Republic of China (NHC) Key Laboratory of Parasite and Vector Biology; World Health Organization (WHO) Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China.. Electronic address:

The tegument of schistosomes is the interface between the worm and the host environment. Some molecules distributed on the tegument participate in host-parasite interactions. Aspartyl aminopeptidase (AAP), identified on the tegument of Schistosoma japonicum (S. Read More

Acta Biomater 2022 May 15. Epub 2022 May 15.

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands. Electronic address:

Cells and their surrounding extracellular matrix (ECM) are engaged in dynamic reciprocity to maintain tissue homeostasis: cells deposit ECM, which in turn presents the signals that define cell identity. This loop of phenotype is obvious for biochemical signals, such as collagens, which are produced by and presented to cells, but the role of biomechanical signals is also increasingly recognised. In addition, cell shape goes hand in hand with cell function and tissue homeostasis. Read More

Acta Biomater 2022 May 15. Epub 2022 May 15.

Beijing Innovation Center for Engineering Science and Advanced Technology, Peking University, Beijing 100871, China. Electronic address:

The ability to selectively capture biomacromolecules and other components from solution has many important applications in biotechnology. However, capturing targets from solution while minimizing interference with the sample solution is still challenging. Here, we describe the design and assembly of a group of DNA hydrogels consisting of long single-stranded DNA produced by rolling amplification reaction (RCA) and crosslinked by DNA duplexes. Read More

Acta Med Port 2022 May 18. Epub 2022 May 18.

Breast Clinic. General Surgery Service. Portuguese Oncology Institute Francisco Gentil. Lisbon. Portugal.

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare CD30 positive T cell lymphoma whose incidence has recently increased. Until 2020, 733 cases of BIA-ALCL and 36 deaths have been reported around the world, with only one confirmed case in Portugal. The authors describe two clinical cases of BIA-ALCL after breast cancer reconstruction using macrotextured implants. Read More

Acta Cir Bras 2022 13;37(3):e370302. Epub 2022 May 13.

PhD. Universidade Federal do Ceará - Postgraduate Program in Biotechnology - Sobral (CE), Brazil.

Purpose: Poultry by-products can contribute as an innovative natural source for the development of composites based on polymers and minerals aiming at bone regeneration. The objective of this study was the physicochemical and biological characterization of collagen-based hydrogels crosslinked with ultraviolet (UV)-riboflavin.

Methods: Pure hydrogels of 100% collagen (G1) or hybrid hydrogels, 90% collagen:10% apatite (G2), 90% collagen:10% nanokeratin (G3), and 90% collagen:5% apatite:5% nanokeratin (G4) were characterized by scanning electron microscope, Fourier-transform infrared spectroscopy, differential scanning calorimetry, swelling degree and quali-quantitative histological analysis. Read More

Acta Cir Bras 2022 13;37(3):e370301. Epub 2022 May 13.

MD. Anhui Medical University - Wuxi Clinical College - 904th Hospital of Joint Logistic Support Force of PLA - Department of Neurology - Wuxi, China.

Purpose: Spontaneous intracerebral hemorrhage (ICH) is a major public health problem with a huge economic burden worldwide. Ulinastatin (UTI), a serine protease inhibitor, has been reported to be anti-inflammatory, immune regulation, and organ protection by reducing reactive oxygen species production, and inflammation. Necroptosis is a programmed cell death mechanism that plays a vital role in neuronal cell death after ICH. Read More

Acta Anaesthesiol Scand 2022 May 18. Epub 2022 May 18.

Specialised Health Care services, Quality and Clinical Pathways, Norwegian Directorate of Health, P. O. Box 220, Skøyen, Oslo, Norway.

Background: According to current guidelines initial burn resuscitation should be performed with fluids alone. The aims of the study were to review the frequency of use of vasoactive and/or inotropic drugs in initial burn resuscitation, and assess benefits and harms of adding such drugs to fluids.

Methods: A systematic literature search was conducted in PubMed, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, UpToDate, and SveMed+ through 3 December 2021. Read More

Acta Anaesthesiol Scand 2022 May 18. Epub 2022 May 18.

Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Background: Melatonin is widely employed as a hypnotic in various patient groups. In intensive care patients, melatonin seems to be increasingly used due to potential clinical effects and a favorable safety profile.

Objectives: We aimed to investigate the extend of usage and clinical practice of melatonin therapy in intensive care departments in Denmark. Read More

Mikrochim Acta 2022 May 18;189(6):223. Epub 2022 May 18.

Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, 310018, China.

Nine kinds of carbon dots (CDs) were synthesized by using fruits with different varieties as carbon sources; meanwhile, the fluorescence characteristics, quantum yield, and response ability to different metal ions and free radicals were systematically studied. These CDs showed similar excitation and emission spectral ranges (λ ≈ 345 nm, λ ≈ 435 nm), but very different fluorescence quantum yield (QY), in which orange and cantaloupe CDs have the highest QY around 0.25 and green plum CDs showed the lowest quantum yield around 0. Read More

Acta Chir Belg 2022 May 18:1-5. Epub 2022 May 18.

Department of Abdominal Surgery, Grand Hôpital de Charleroi, Gilly, Belgium.

Background: Pheochromocytoma is a rare catecholamine-secreting tumor of neuroendocrine origin. It has a prevalence of <1% in adults with hypertension. In some cases, hypertension is associated with the classical triad of headache, sweating, and tachycardia. Read More

Acta Psychiatr Scand 2022 May 18. Epub 2022 May 18.

Department of Psychosis, Institute of Mental Health, Singapore.

Acta Psychiatr Scand 2022 May 18. Epub 2022 May 18.

Instituto de Investigación Sanitaria (IDIS) de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), Servizo Galego de Saúde (SERGAS), Santiago de Compostela, Galicia, Spain.

Objective: To test whether a schizophrenia polygenic risk score (PRS) based on the subset of polymorphisms that affect brain expression of genes with altered expression by antipsychotics (exprAP PRS) is associated with psychiatric readmission of patients with schizophrenia.

Methods: The study involved 427 patients with schizophrenia. Genes with altered expression by antipsychotics were extracted from the Comparative Toxigenomics Database. Read More

Acta Obstet Gynecol Scand 2022 May 18. Epub 2022 May 18.

Obstetrics and Gynecology, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction: Placental abruption can result in serious perinatal morbidity and mortality. However, it is not clear whether placental abruption could lead to neonatal anemia, as a direct relationship has not been described yet. The objective of this study is to investigate whether there is a relationship between occurrence of placental abruption and neonatal anemia. Read More

Acta Cardiol 2022 May 18:1-8. Epub 2022 May 18.

Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, Canada.

Background: Identifying prolonged QT interval in RBBB has been problematic.

Methods: Four approaches were compared to adjust for the QT prolongation in intermittent RBBB. The implications were assessed in a separate group of 200 persons with established RBBB. Read More

Acta Cardiol 2022 May 18:1-2. Epub 2022 May 18.

Université Catholique de Louvain, CHU UCL Namur, Service de Cardiologie, Yvoir, Belgium.

Acta Paediatr 2022 May 17. Epub 2022 May 17.

Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Canada.

Aim: To develop and perform an initial validation of a score to measure severity of illness in hospitalized children with severe acute malnutrition (SAM).

Methods: A prospective study enrolled SAM children aged 6-59 months hospitalized in Borno State, Nigeria. Candidate items associated with inpatient mortality were combined and evaluated as candidate scores. Read More

Acta Paediatr 2022 May 17. Epub 2022 May 17.

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Aim: To assess associations between air pollution exposure and infant lung function.

Methods: Healthy infants from Stockholm were recruited to two cohorts (n=99 and n=78). Infant spirometry included plethysmography and raised volume forced expiratory flows. Read More

Acta Paediatr 2022 May 17. Epub 2022 May 17.

Pediatric Allergy Unit, Pediatrics Section, Department of Life Sciences and Public Health, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacre Hearth, Rome, Italy.

Acta Astronaut 2022 May 13. Epub 2022 May 13.

Department of Aerospace and Mechanical Engineering, Sapienza University of Rome, Via Eudossiana, 18 - 00184, Rome, Italy.

The pandemic emergency caused by the spread of COVID-19 has stressed the importance of promptly identifying new epidemic clusters and patterns, to ensure the implementation of local risk containment measures and provide the needed healthcare to the population. In this framework, artificial intelligence, GIS, geospatial analysis and space assets can play a crucial role. Social media analytics can be used to trigger Earth Observation (EO) satellite acquisitions over potential new areas of human aggregation. Read More

Acta Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Purpose: To investigate the association between proteinuria and the incidence of retinal vein occlusion (RVO) in individuals with preserved renal function.

Methods: We conducted a retrospective cohort study from 2005 to 2020 using the JMDC Claims Database, a large database of health check-ups and administrative claims in Japan. Individuals who underwent annual health check-ups were included. Read More

Acta Radiol 2022 May 17:2841851221101881. Epub 2022 May 17.

Division of Musculoskeletal Imaging and Intervention, Department of Radiology, 2348Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.

Background: Previous studies suggest an overall decrease of Paget's disease of bone (PDB) prevalence. However, a large number of asymptomatic patients make previously reported prevalence likely underrepresented.

Purpose: To evaluate the prevalence of PDB in our patient population. Read More

Acta Neuropathol Commun 2022 May 17;10(1):77. Epub 2022 May 17.

Department of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Acta Neuropathol 2022 May 17. Epub 2022 May 17.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Amyloid beta (Aβ) plaque is a defining pathologic feature of Alzheimer disease (AD). Aducanumab, a monoclonal IgG1 that selectively binds aggregated species of Aβ, has been shown by amyloid positron emission tomography (Amyloid PET) to reduce Aβ plaques in patients with prodromal and mild AD. This is the first autopsy report of the AD neuropathology in a patient previously treated with aducanumab. Read More

Acta Pharmacol Sin 2022 May 17. Epub 2022 May 17.

Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, Department of Anatomy, NHC and CAMS Key Laboratory of Medical Neurobiology, College of Pharmaceutical Sciences, Zhejiang University School of Medicine, Hangzhou, 310000, China.

Our previous study showed that H receptor antagonists reduced neuronal apoptosis and cerebral infarction in the acute stage after cerebral ischemia, but through an action independent of activation of histaminergic neurons. Because enhanced angiogenesis facilitates neurogenesis and neurological recovery after ischemic stroke, we herein investigated whether antagonism of HR promoted angiogenesis after brain ischemia. Photothrombotic stroke was induced in mice. Read More

Acta Pharmacol Sin 2022 May 17. Epub 2022 May 17.

The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.

Glioblastoma (GBM), a malignant brain tumor, is a world-wide health problem because of its poor prognosis and high rates of recurrence and mortality. Apolipoprotein C1 (APOC1) is the smallest of apolipoproteins, implicated in many diseases. Recent studies have shown that APOC1 promotes tumorigenesis and development of several types of cancer. Read More

Acta Biomater 2022 May 14. Epub 2022 May 14.

Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:

Zinc (Zn)-based composites have received extensive attention as promising biodegradable materials due to their unique combination of moderate biodegradability, biocompatibility, and functionality. Nevertheless, the low mechanical strength of as-cast Zn-based composites impedes their practical clinical application. Here we reported the mechanical properties, corrosion behavior, wear properties, and cytotoxicity of in situ synthesized biodegradable Zn-xMgGe (x = 1, 3, and 5 wt. Read More

Acta Biomater 2022 May 14. Epub 2022 May 14.

Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, P. R. China.. Electronic address:

Using bacteria for tumor-targeted therapy has attracted much attention in recent years. However, how to improve the targeted delivery and cancer therapy efficacy is an important but challenging scientific issue. Herein, a drug delivery system using a probiotic as a carrier was developed for tumor-targeted photodynamic and sonodynamic synergistic therapy. Read More

Acta Biomater 2022 May 14. Epub 2022 May 14.

3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.

The combination of natural resources with biologically active biocompatible ionic liquids (Bio-IL) is presented as a combinatorial approach for developing tools to manage inflammatory diseases. Innovative biomedical solutions were constructed combining silk fibroin (SF) and Ch[Gallate], a Bio-IL with antioxidant and anti-inflammatory features, as freeze-dried 3D-based sponges. An evaluation of the effect of the Ch[Gallate] concentration (≤3% w/v) on the SF/Ch[Gallate] sponges was studied. Read More

Acta Biomater 2022 May 14. Epub 2022 May 14.

Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Division and the 4th Medical Center of Chinese PLA General Hospital, Beijing, 100048, China; Chinese PLA Medical School, Beijing, 100853, China; Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing, 100048, China; PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, Beijing, 100048, China. Electronic address:

Endothelial malfunction is responsible for impaired angiogenesis in diabetic patients, thereby causing the delayed healing progress of diabetic wounds. Exosomes or extracellular vesicles (EVs) have emerged as potential therapeutic vectors carrying drug cargoes to diseased cells. In the present study, EVs were reported as a new treatment for diabetic wounds by delivering VH298 into endothelial cells. Read More