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Acta Cytol 2019 Apr 17:1-8. Epub 2019 Apr 17.

Center for Personalized Diagnostics, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

As the value of molecular testing of cancer specimens increases, the number of tests imposed on tumor specimens also increases, often in tension with the amount of tumor material available. To develop and validate molecular assays for limited specimens, there are specific concerns that must be addressed, including DNA quality, quantity, and abundance; the number of targets/ability to multiplex; and the analytical sensitivity and specificity of the assay itself. Ultimately, weighing these considerations during assay validation in the overall context of clinical utility and laboratory workflow is critical for delivering the highest level of personalized care to patients. Read More

Acta Haematol 2019 Apr 17:1-7. Epub 2019 Apr 17.

Institute of Medical Biochemistry and Laboratory Diagnostics, Thrombotic Center, General University Hospital, and First Faculty of Medicine, Charles University, Prague, Czech Republic.

Background/aims: Endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) have been described as markers of endothelial damage and dysfunction in several diseases, including deep venous thrombosis. Their role in patients with known thrombophilia has not yet been evaluated. Both EPCs and CECs represent extremely rare cell populations. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 9;218:213-220. Epub 2019 Apr 9.

Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, China. Electronic address:

Fluorescent chemosensors based on a new macrocyclic compound, multifarene[2,2], with modification by triazole-linked pyrene or anthracene were synthesized. These macrocyclic sensors exhibited high affinity and selectivity toward Ag over other metal ions, with ratiometric or enhanced response of their fluorescence emissions depending upon the substituent species for coordination to Ag, and an unexpected response to a concentration threshold of the metal cations was discovered. The experimental evidences of fluorescence spectra, H NMR titration, IR spectra, and high-resolution mass spectra suggested the coordination behaviors of the sensors with Ag, that is, the 1:1 complexes were formed with moderate association constants of about 10 L·mol, and the sulfur atoms on macrocyclic ligand should affinite to the metal cations. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Mar 29;218:206-212. Epub 2019 Mar 29.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China. Electronic address:

Hydrogen sulfide (HS) is a kind of gaseous signal molecule in many physiological processes. In order to detect HS, a novel "turn on" fluorescent probe 6,12-dihydroxyperylene-1,7-dione (DPD) was designed and synthesized. The probe DPD is fluorescence silence, while the addition of HS induces an obvious green fluorescence with an obvious color change from dark blue to yellow-green. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 4;218:196-205. Epub 2019 Apr 4.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:

Four novel highly selective 8-hydroxyquinoline-based fluorescent chemodosimeters (1-4) were synthesized for the rapid analysis of Hg in aqueous solution and on paper strips, which probably attributed to the excited state intramolecular proton transfer (ESIPT) process. Chemodosimeter 1 was evaluated as a Hg-ratiometric fluorescent sensor while others (2, 3 and 4) displayed fluorescence turn-on response for Hg among the various survey metal ions. We demonstrated that chemodosimeters (1-4) could recognized Hg ions based on a 1:1 stoichiometric binding event with fast detection time. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 6;218:191-195. Epub 2019 Apr 6.

Instituto Universitario Mixto de Tecnología Química, Universitat Politècnica de València (UPV-CSIC), Av. Los Naranjos s/n, 46022, Valencia, Spain. Electronic address:

2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting photosensitiser for cyclobutane pyrimidine dimers (CPDs) formation. In the present paper, a complete UV-Vis transient absorption spectroscopic characterisation of this compound is provided, including triplet-triplet spectra, triplet lifetimes and rate constants for quenching of 2M by a dimeric thymine derivative. Read More

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Oporto, Portugal; EpiUnit, Epidemiology Research Unit, Institute of Public Health of the University of Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Oporto, Portugal. Electronic address:

A total of 100 domestic cats from Luanda (Angola) were tested for the presence of antibodies against Bartonella henselae and spotted fever group of Rickettsia (SFGR) using indirect immunofluorescence assay (IFA). Molecular screening targeting the riboflavin synthase (ribC) gene for Bartonella and outer membrane protein B (ompB) gene for Rickettsia, using conventional PCR and sequencing was also performed in cat´s blood samples. Sixty-six percent of the cats from Luanda had IgG antibodies against Bartonella species but none of them had antibodies against SFGR. Read More

Acta Trop 2019 Apr 14. Epub 2019 Apr 14.

Departamento de Parasitología, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain.

Proteolytic activity was studied in two sibling species of Anisakis (Nematoda: Anisakidae), A. simplex s.s. Read More

Acta Chir Belg 2019 Apr 17:1-28. Epub 2019 Apr 17.

a Department of Thoracic and Vascular Surgery , Ghent University Hospital , Ghent , Belgium.

Background: In 2009 and 2011 respectively ESVS and AHA/ASA guidelines recommended to operate patients with a symptomatic carotid artery stenosis within 14 days. This study aimed primarily to determine if an academic hospital has implemented these international guidelines about indication and timing of surgical treatment of carotid stenosis. Secondary, the influence of referral from another hospital on time from symptoms to surgery and the influence of time between neurological event and surgery on 30-day complication rate was studied. Read More

Acta Oncol 2019 Apr 17:1-9. Epub 2019 Apr 17.

a The Sir Peter MacCallum Department of Oncology , The University of Melbourne , Melbourne , Australia.

Background: Previous studies have identified apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can stratify prostate cancer into high- and low-grade disease (HG and LG, respectively). In this study, we consider the improvement of incorporating texture features (TFs) from T2-weighted (T2w) multiparametric magnetic resonance imaging (mpMRI) relative to mpMRI alone to predict HG and LG disease.

Material And Methods: In vivo mpMRI was acquired from 30 patients prior to radical prostatectomy. Read More

Acta Oncol 2019 Apr 17:1-10. Epub 2019 Apr 17.

a Institute of Neurology , Medical University of Vienna , Vienna , Austria.

Background: Primary CNS lymphoma is a highly aggressive and rare type of extranodal non-Hodgkin lymphoma. Although, new therapeutic approaches have led to improved survival, the management of the disease poses a challenge, practice patterns vary across institutions and countries, and remain ill-defined for vulnerable patient subgroups.

Material And Methods: Using information from the Austrian Brain Tumor Registry we followed a population-based cohort of 189 patients newly diagnosed from 2005 to 2010 through various lines of treatment until death or last follow-up (12-31-2016). Read More

Acta Orthop 2019 Apr 17:1-10. Epub 2019 Apr 17.

a Department of Orthopaedic Surgery , University of Turku and Turku University Hospital , Turku.

Background and purpose - The use of trabecular metal (TM) cups for primary total hip arthroplasty (THA) is increasing. Some recent data suggest that the use of TM in primary THA might be associated with an increased risk of revision. We compared implant survival of Continuum acetabular cups with other commonly used uncemented cups. Read More

Acta Orthop 2019 Apr 17:1-9. Epub 2019 Apr 17.

b The Swedish Knee Arthroplasty Register , Lund , Sweden.

Background and purpose - Patient-reported outcome (PRO) in total knee arthroplasty (TKA) patients with high body mass index (BMI) is controversial. We compared pain, function, quality of life, general health, and satisfaction among different BMI categories preoperatively and 1 year after primary TKA. Patients and methods - 4,318 patients were operated with a TKA for knee osteoarthritis in the Region of Skane in 2013-2015. Read More

Acta Orthop 2019 Apr 17:1-9. Epub 2019 Apr 17.

a Department of Orthopaedics, Institute of Clinical Sciences , Sahlgrenska Academy, University of Gothenburg , Gothenburg ;

Background and purpose - It is unclear whether physiotherapy interventions or patient education before total hip replacement (THR) is beneficial for patients postoperatively. Utilizing the Swedish Hip Arthroplasty Register (SHAR), we retrospectively studied the influence of preoperative self-reported exposure to physiotherapy and/or patient education on patient-reported outcomes 1 year after THR. Patients and methods - Data covering all THRs performed in Sweden for osteoarthritis, between the years 2012 and 2015, was obtained from SHAR. Read More

J Oral Rehabil 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurosciences, Reproductive Sciences and Oral Sciences, Division of Orthodontics, University of Naples "Federico II", Naples, Italy.

Objectives: to evaluate the prevalence of temporomandibular disorder pain (TMD-pain), temporomandibular joint (TMJ) noises, and oral behaviors in an Italian adult population sample, and their possible association with gender, oral behaviors, self-reported facial trauma and orthodontic treatment.

Methods: Subjects older than 18 years were recruited from general population in public spaces during their daily life. A specific questionnaire was developed to collect data on TMD-pain, TMJ noises, oral behaviors, orthodontic treatment and facial trauma. Read More

Acta Obstet Gynecol Scand 2019 Apr 16. Epub 2019 Apr 16.

Women's Health and Perinatology Research Group, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway.

Introductio: High levels of anti-Mullerian hormone and a high antral follicle count in women with polycystic ovary syndrome, reflecting increased ovarian antral follicles, predisposes them to have a high number of retrieved oocytes at in-vitro fertilisation (IVF)/ intra-cytoplasmic sperm injection (ICSI) and an increased risk of ovarian hyperstimulation syndrome. Inositols, which act as insulin sensitizers have the potential to alter folliculogenesis and the functional ovarian reserve with subsequent benefits to reproductive outcomes following IVF/ICSI treatment. Published literature is however unable to provide definitive evidence of its efficacy. Read More

Acta Neurol Scand 2019 Apr 16. Epub 2019 Apr 16.

Department of Emergency Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Los Angeles, US.

Objective: To compare the efficacy of buccally absorbed prochlorperazine (BAP) to intravenous prochlorperazine (IVP) for the abortive treatment of migraine headaches.

Methods: Randomized double-blind trial. Eighty subjects aged 18-65 presenting with migraines to the ED of a safety-net, urban hospital. Read More

Acta Anaesthesiol Scand 2019 Apr 17. Epub 2019 Apr 17.

Department of Anesthesiology and Intensive Care, East Section, Aarhus University Hospital, Aarhus, Denmark.

Background: Delirium is a serious medical problem and recognized as a common syndrome in critically ill children. Without routine screening, delirium diagnosis is often missed by the medical providers. Internationally, there are tools to assess pediatric delirium (PD), but none currently available in Danish. Read More

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132, Genoa, Italy.

Aims: Metabolic surgery is considered as a therapeutic option for obese patients with type 2 diabetes (T2D). In order to identify novel laboratory variables that could improve the selection of patients who might greatly benefit from a surgical approach, we focused on the neutrophil-to-lymphocyte ratio (NLR) as a predictor of long-term T2D remission following metabolic surgery.

Methods: Thirty-one obese patients with T2D included in this pilot study underwent Roux-en-Y gastric bypass or biliopancreatic diversion (BPD) at the Surgical Department of Genoa University, IRCCS Ospedale Policlinico San Martino in Genoa (Italy). Read More

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia.

Aims: Little is known regarding initiation of insulin therapy in type 2 diabetes (T2D) in Central and South-Eastern European countries. Therefore, we conducted a survey to characterise the prescribing practices of specialist diabetes healthcare professionals in this region and assessed factors that influence clinical decision-making regarding insulin initiation in T2D.

Methods: A cross-sectional survey sampled 211 specialist diabetes healthcare prescribers from five Central and South-Eastern European countries (Bulgaria, Croatia, Greece, Hungary, and Slovenia). Read More

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy.

Aims: Patients with type 2 diabetes (T2D) have an increased risk of cardiovascular disease. Recent cardiovascular outcome trials (CVOTs) with liraglutide, semaglutide, and albiglutide have shown significant reduction in major adverse cardiovascular events. Conversely, the CVOT with exenatide long-acting release (ELAR) confirmed cardiovascular safety of the drug, but did not reached superiority versus placebo. Read More

Biochim Biophys Acta Mol Cell Res 2018 Nov 18;1865(11 Pt B):1838-1845. Epub 2018 Aug 18.

Université Paris Sud, UMRS1174, Orsay F-91405, France; Institut National de la Santé et de la Recherche Médicale (Inserm), UMRS1174, Orsay F-91405, France. Electronic address:

Recent reports have highlighted the pivotal role of Ca during host cell infection by bacterial pathogens. Here, we review how bacterial pore-forming toxins (PFTs) trigger global Ca signals to regulate cell adhesion-, inflammatory- or death processes. We comment recent reports describing the role of bacterial effectors injected by a type III secretion system (T3SS) as well as host cell players in the formation of Ca microdomains during Shigella invasion and Chlamydia extrusion of host cells. Read More

Biochim Biophys Acta Mol Cell Res 2018 Nov 9;1865(11 Pt B):1718-1732. Epub 2018 Aug 9.

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA; UCI Center for Autism Research and Translation, School of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Pediatrics, Section of Human Genetics and Genomics, University of California, Irvine, Irvine, CA, USA. Electronic address:

Autism spectrum disorder (ASD) is a group of complex, neurological disorders that affect early cognitive, social, and verbal development. Our understanding of ASD has vastly improved with advances in genomic sequencing technology and genetic models that have identified >800 loci with variants that increase susceptibility to ASD. Although these findings have confirmed its high heritability, the underlying mechanisms by which these genes produce the ASD phenotypes have not been defined. Read More

Biochim Biophys Acta Mol Cell Res 2018 Nov 10;1865(11 Pt B):1846-1856. Epub 2018 Aug 10.

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. Electronic address:

Toxoplasma gondii has a complex life cycle involving different hosts and is dependent on fast responses, as the parasite reacts to changing environmental conditions. T. gondii causes disease by lysing the host cells that it infects and it does this by reiterating its lytic cycle, which consists of host cell invasion, replication inside the host cell, and egress causing host cell lysis. Read More

Acta Otorrinolaringol Esp 2019 Apr 13. Epub 2019 Apr 13.

Servicio de Otorrinolaringología, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Barcelona, España.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 8;218:184-190. Epub 2019 Apr 8.

College of Physics and Material Science, Henan Normal University, Xinxiang 453007, China. Electronic address:

The potential energy curves are calculated for the aΠ, bΣ, cΣ, dΠ, and eΣ states of the AlO cation using the valence internally contracted multireference configuration interaction approach. The transition dipole moments are computed between these states. To improve the reliability and accuracy of the potential energy curves, several corrections are included, namely, Davidson correction, core-valence correlation and scalar relativistic corrections, as well as extrapolation of the potential energies to the complete basis set limit. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 10;218:178-183. Epub 2019 Apr 10.

School of Chemistry & Environmental Research Institute, University College Cork, Cork, Ireland; Atmospheric Chemistry Department (ACD), Leibniz Institute for Tropospheric Research (TROPOS), 04318 Leipzig, Germany. Electronic address:

Most extinction measurements require a stable light source to attain high precision and accuracy. Here, we present a convenient approach to normalize light source intensity in broadband optical cavity measurements. In the absence of sample extinction, we show that the in-band signal - the high finesse spectral region of the optical cavity in which sample extinction is measured with high sensitivity - is strongly correlated with the out-of-band signal. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 4;218:171-177. Epub 2019 Apr 4.

Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi 330013, PR China. Electronic address:

In this work, a novel probe D-HBT-NBD (1O) based on diarylethene to detect biothiols (including Cys, Hcy and GSH) was synthesized and the relative colorimetric and fluorescent properties were tested. The probe exhibited excellent photochromic properties and showed apparent colorimetric and fluorescent signals for Cys, Hcy and GSH. The probe can selectively detect Cys, Hcy and GSH by naked eyes for its open-ring isomer 1O and can discriminate Cys from Hcy/GSH by apparent color change from light orange to dark pink at the closed-ring state under the irradiation of UV light. Read More

Acta Trop 2019 Apr 13. Epub 2019 Apr 13.

Department of Cardiac, Thoracic and Vascular Sciences & Public Health, Unit of Hygiene and Public Health, University of Padua. Via L. Loredan, 18 - 35131 Padua, Italy. Electronic address:

Soil transmitted helminthiasis (STHs) are endemic in Nepal but since the country territory is extremely heterogeneous, a multidisciplinary assessment is required to evaluate the risk of infection in different areas. Prevalence data were retrieved with systematic literature search and geographical coordinates were assigned to each survey site. Spatial stratification was then implemented considering land use and ecological parameters. Read More

Biochim Biophys Acta Biomembr 2019 Apr 13. Epub 2019 Apr 13.

Division BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Netherlands. Electronic address:

The intercellular lipid matrix of the stratum corneum (SC), which consist mainly of ceramides (CERs), free fatty acids and cholesterol, is fundamental to the skin barrier function. These lipids assemble into two lamellar phases, known as the long and short periodicity phases (LPP and SPP respectively). The LPP is unique in the SC and is considered important for the skin barrier function. Read More

Acta Otolaryngol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Department of Otolaryngology , Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.

Background: Unilateral labyrinthectomy (UL) causes the disappearance of ipsilateral medial vestibular nuclear (ipsi-MVe) activity and induces spontaneous nystagmus (SN), which disappears during the initial process of vestibular compensation (VC). Ipsi-MVe-activity restores in the late process of VC.

Objective: We evaluated the late process of VC after UL in rats and examined the effects of thioperamide (H3 antagonist) on VC. Read More

Acta Obstet Gynecol Scand 2019 Apr 15. Epub 2019 Apr 15.

Department of Gynecology and Obstetrics, Research institute "Reproduction and Development", Amsterdam UMC, location VU medical center, Amsterdam, The Netherlands.

With interest we read the correspondence of Bamberg et al. and Scioscia et al. about the randomized controlled trial of the first authors concerning the uterine niche after caesarean section (CS). Read More

Acta Neurol Belg 2019 Apr 15. Epub 2019 Apr 15.

Amity Institute of Neuropsychology and Neurosciences (AINN), Amity University UP, Room No. 222A, J1 Block, Sector 125, Noida, 201303, India.

Mental imagery is a quasi-perceptual experience in the absence of external stimuli. This concept has intrigued psychologists, sportspersons, neurologists and other scientists for over a decade now. Imagery has been used in rehabilitation and the results have been promising. Read More

Acta Neurol Belg 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmaceutics, the First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiankang Road, Weihui, 453100, Henan, People's Republic of China.

Neuropathic pain is a major public health problem because it has a considerable impact on life quality of patients. Neuropathic pain caused by a lesion or disease of the somatosensory nervous system, which causes unpleasant and abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), and pain in response to a stimulus that does not normally provoke pain (allodynia). P2X receptors from dorsal root ganglion (DRG) play a crucial role in facilitating pain transmission at peripheral and spinal sites. Read More

Mikrochim Acta 2019 Apr 15;186(5):286. Epub 2019 Apr 15.

Laboratory of Biometrology, Shanghai Institute of Measurement and Testing Technology, Shanghai, 201203, People's Republic of China.

A convenient and ultrasensitive fluorometric method is described for the determination of HIV DNA. It exploits the strong difference in the affinities of MoS nanosheets for long ssDNA versus short oligonucleotide fragments. In addition, efficient signal amplification is accomplished by exonuclease III-assisted target recycling. Read More

Mikrochim Acta 2019 Apr 13;186(5):282. Epub 2019 Apr 13.

College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, Shandong, China.

A fluorometric turn-on assay is described for ascorbic acid (AA). It is based on the controlled release of polyallylamine-stabilized gold nanoclusters (polyallylamine-AuNCs) from MnO nanosheets. In an aqueous solution of near-neutral pH value, the positively charged capped AuNCs are adsorbed on the surface of the negatively charged MnO nanosheets. Read More

Mikrochim Acta 2019 Apr 15;186(5):287. Epub 2019 Apr 15.

College of Biological, Chemical Sciences and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing, 314001, Zhejiang, China.

The authors describe a fluorometric assay for cardiac myoglobin (Mb), a marker for myocardial infarction. An Mb-binding aptamer was labeled with pyrene and adsorbed on the surface of graphene oxide (GO) via noncovalent and reversible binding forces. This causes the fluorescence of pyrene (best measured at excitation/emission wavelengths of 275/376 nm) to be quenched. Read More

Mikrochim Acta 2019 Apr 15;186(5):288. Epub 2019 Apr 15.

State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 361005, China.

Carbon dots doped with nitrogen and copper have been synthesized via a hydrothermal method. They possess favorable peroxidase-like catalytic activity over a wide range of pH values and temperatures. Specifically, they were used to catalyze the oxidation of ortho- and para-phenylenediamine (OPD and PPD) by HO. Read More

Mikrochim Acta 2019 Apr 13;186(5):280. Epub 2019 Apr 13.

School of Chemistry and Chemical Engineering, and Institute of Surface Analysis and Chemical Biology, University of Jinan, Jinan, 250022, China.

A nanozyme-linked immunosorbent assay is described for cardiac troponin I which is a biomarker for myocardial infarction. The method is based on the use of Pd-Ir nanocubes with excellent peroxidase-like activity. The nanocubes catalyze the oxidization of nonfluorescent o-phenylenediamine (OPD) by HO to form a yellow fluorescent product (oxOPD) with excitation/emission maxima at 400/570 nm. Read More

Mikrochim Acta 2019 Apr 15;186(5):285. Epub 2019 Apr 15.

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, 106, Taiwan, Republic of China.

A carbon nanofiber functionalized with ruthenium(II)-tetrasulfonato phenyl porphine (CNF/Ru-TSPP) is shown to be viable sensor for amperometric determination of the antipsychotic drug chlorpromazine (CPZ). The hollow platelet structured Ru-TSPP combines with the hollow cylindrical tube-like structure of the CNF via π stacking interaction. The morphological and electro conductive properties of the electrode were characterized by spectrophotometric techniques. Read More

Mikrochim Acta 2019 Apr 13;186(5):281. Epub 2019 Apr 13.

College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo/Biosensing, The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-based Materials, Anhui Normal University, Wuhu, 241000, People's Republic of China.

A turn-on fluorescent sulfide probe was prepared from carbon dots (CDs; synthesized using an environmentally friendly method) and MnO nanosheets. In this composite probe, the fluorescence of the CDs (with excitation/emission peaks at 330/430 nm) is quenched by the MnO nanosheets through an inner filter effect. Introducing sulfide causes the MnO nanosheets to be disintegrated through a redox reaction between sulfide and MnO. Read More

Acta Neurochir (Wien) 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurosurgery, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga-shi, Saga, 849-8501, Japan.

Background: The most frequent neurological complication during coil embolization of a ruptured cerebral aneurysm is a thromboembolic event. The association between the tortuosity of the internal carotid artery (ICA) and thromboembolic events (TEEs) during coil embolization of ruptured cerebral aneurysms remains unclear. The present study aimed to investigate the association between extracranial ICA tortuosity and thromboembolic complications during coil embolization of anterior circulation ruptured aneurysms. Read More

Acta Neurochir (Wien) 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurosurgery, University Hospital Münster, Germany Albert-Schweitzer-Campus 1, Building A1, 48149, Munster, Germany.

Background: 5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better differentiation between tumor and normal brain tissue, allowing a higher degree of resection, and improves patient outcomes. In recent years, several reports have emerged regarding the use of 5-ALA in other brain tumor entities, including pediatric brains tumors. Since gross total resection (GTR) of many brain tumors in children is crucial and the role of 5-ALA-guided resection of these tumors is not clear, we sought to perform a comprehensive literature review on this topic. Read More

Acta Neurochir (Wien) 2019 Apr 15. Epub 2019 Apr 15.

Brain Physics Laboratory, Division of Neurosurgery, Dept of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

Incorrect family name of Nino Stocchetti. Read More

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, 430030, Hubei, China.

Aims: Observational studies indicated that resting heart rate (RHR) was associated with diabetes mellitus (DM) risk; however, it remains unclear whether the association between RHR and DM is causal. We aimed to examine whether there was causal association of RHR with DM risk.

Methods: A prospective study including 16,201 middle-aged and older Chinese (7031 males and 9170 females) derived from the Dongfeng-Tongji cohort was performed. Read More

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.

Aim: More than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have glucose intolerance or diabetes. The association has led to two hypotheses: PDAC causes diabetes or diabetes shares risk factors for the development of PDAC. In order to elucidate the relationship between diabetes and PDAC, we investigated the glucose metabolism during tumorigenesis in the LSL-Kras; LSL-Trp53; and Pdx-1-Cre (KPC) mouse, a genetically engineered model of PDAC. Read More

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Golisano Children's Hospital, University of Rochester, 601 Elwood Ave, Box 690, Rochester, NY, 14642, USA.

Aims: The skeletal complications of type 1 diabetes (T1D) include low bone density, poor bone quality and fractures. Greater calcium intake, vitamin D intake, and physical activity are commonly recommended to improve bone health in patients with T1D. However, it is not clear whether these factors are affected by T1D or improve clinical outcomes. Read More

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

Aims: Patients with type 2 diabetes have been considered a susceptible group for pulmonary dysfunction. Our aim was to assess pulmonary function on the prediabetes stage.

Methods: Pulmonary function was assessed in 4,459 non-diabetic subjects, aged between 45 and 70 years, without cardiovascular disease or chronic pulmonary obstructive disease from the ongoing study ILERVAS. Read More

Mikrochim Acta 2019 Apr 13;186(5):283. Epub 2019 Apr 13.

School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.

Biofuel cells (BFCs) based on anodic oxidation and cathodic oxygen reduction represent an attractive alternative to self-powered devices. A glucose/oxygen BFC is described for monitoring glucose. It is making use of a piece of paper carrying a glucose oxidase (GOx) based bioanode, and a bilirubin oxidase (BilOx) based biocathode. Read More

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 16. Epub 2019 Apr 16.

Protein Science Laboratory of the Ministry of Education, School of Life Science, Tsinghua University, Beijing, China.

Molluscan shell is a biomineral that consists of a highly organized calcium carbonate composite. Organisms mainly use matrix proteins to elaborately control the biomineralization process, but knowledge of their regulatory mechanisms is limited. The transcription factor Pf-Rel, which belongs to the Rel/nuclear factor-κB family, was shown to regulate transcription at the Nacrein promoter in the pearl oyster Pinctada fucata. Read More