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Acta Paediatr 2019 Apr 20. Epub 2019 Apr 20.

King's College London School of Medical Education, Guy's Campus, Great Maze Pond, London.

We read with great interest the article by Sofou and Bry (1) on the use of a new tool for oral case presentation in the paediatric emergency department. As medical students in London, we have had varying degrees of experience in assessing patients and presenting cases to our colleagues in clinical settings, especially in the emergency department and, more specifically, the paediatric emergency department This article is protected by copyright. All rights reserved. Read More

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Research, Innlandet Hospital Trust, Lillehammer, Norway.

Aim: To estimate the extent to which maternal and paternal height modify the association between length-for-age Z-score (LAZ) and neurodevelopmental outcomes assessed by the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III).

Methods: Baseline data from a clinical trial in 600 Nepalese infants aged 6-11 months with LAZ less than -1 were utilized. The primary exposure was the LAZ score, interaction variables were maternal and paternal height and the outcomes were Bayley-III cognitive, language and motor scaled scores. Read More

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Neonatal Medicine, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Aim: To evaluate long-term cognitive and behavioural outcomes of children with neonatal hypoxic-ischaemic encephalopathy in the absence of cerebral palsy.

Methods: A systematic search was performed on five databases (EMBASE, Medline, PubMed, Web of Science, PsycInfo). Randomised-controlled trials, non-randomised controlled trials, or observational studies, published between 1990-2017, that reported long-term (age ≥ 4 years) cognitive and/or behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy without cerebral palsy were included. Read More

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Neonatology Department, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Madrid, Spain.

Aim: We describe the postnatal weight gain, linear and head growth trends of surviving preterm infants from 2005 to 2017.

Methods: Multicentre cohort study, including surviving preterm infants < 32 weeks (n=21,084), from the Spanish Neonatal Network database, without major congenital malformations who were less than 50 weeks postmenstrual age at discharge. Outcomes were weight gain (g/kg/day), linear and head growth (cm/week) and changes in weight, length and head circumference z-scores from birth to discharge. Read More

Acta Paediatr 2019 Apr 13. Epub 2019 Apr 13.

English Editor, Acta Paediatrica.

Political instability is a global issue and the financial pressures on healthcare and social care have never been greater. In March 2019, the Finnish Government resigned after it failed to deliver much-needed healthcare and welfare reforms. This article is protected by copyright. Read More

Acta Paediatr 2019 Apr 12. Epub 2019 Apr 12.

Department of Clinical Science, Paediatrics, Umeå University, S-901 85, Umeå, Sweden.

Aim: We explored if fluid restriction in very low birth weight infants with a haemodynamically significant patent ductus arteriosus affected energy and protein intakes and growth.

Methods: Retrospectively, we identified 90 very low birth weight infants that were admitted to Umea University Hospital, Sweden, between 2009 and 2012: 42 with and 48 without haemodynamically significant patent ductus arteriosus. Anthropometric, fluid, energy and protein intake data during the first 28 days of life were expressed as z-scores. Read More

Acta Paediatr 2019 Apr 12. Epub 2019 Apr 12.

Department of Pediatrics C, Schneider Children's Medical Center, Petah Tikva, Israel.

Congenital cytomegalovirus (cCMV) is the leading cause of congenital infections, affecting approximately 0.7% of live births worldwide. Although, 85%-90% of infected children are asymptomatic at birth, 10%-15% will develop late onset hearing impairment (1). Read More

Acta Paediatr 2019 Apr 12. Epub 2019 Apr 12.

Department of Pediatrics, Neonatal Research Network of Japan, Kyorin University, Tokyo, Japan.

Acta Paediatr 2019 Apr 10. Epub 2019 Apr 10.

Clinic for Pediatrics I, Medical University of Innsbruck, Austria.

Aim: To evaluate clinical manifestations of tongue-tie as well as short-term and long-term outcomes following frenotomy.

Methods: In this retrospective study, for 329 patients (295 infants and 34 children) who underwent frenotomy between 2011 and 2017, symptoms, short-term and long-term outcomes were evaluated.

Results: Of the 295 infants (median age 6 weeks), 199 (= 60%) showed inadequate breastfeeding. Read More

Acta Paediatr 2019 Apr 9. Epub 2019 Apr 9.

Institute of Developmental Sciences, University of Southampton and NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD, UK.

Cardiovascular disease (CVD) is foremost among the non-communicable diseases (NCDs) which account for 71% of deaths globally each year. CVD is also prominent among the pre-existing conditions still accounting for nearly 25% of maternal deaths, and is linked to gestational diabetes and preeclampsia. Markers of CVD risk have been reported even in young children, related to prenatal factors such as mother's diet or body composition. Read More

Acta Paediatr 2019 Apr 7. Epub 2019 Apr 7.

Department of Pediatrics, Women and Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI, USA.

Acta Paediatr 2019 Apr 7. Epub 2019 Apr 7.

Children's Hospital, Paediatric Research Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Aim: We sought to evaluate the associations between umbilical artery pH and base excess and neurodevelopmental outcome at four years of age.

Methods: This study comprised 84,588 singleton children born alive at term in 2005-2011 in the hospital district of Helsinki and Uusimaa in Finland. Data from the maternity hospital information system were linked to the data from the Medical Birth Register and the Hospital Discharge Register. Read More

Acta Paediatr 2019 Apr 5. Epub 2019 Apr 5.

Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Aim: European consensus guidelines published in May 2013 recommended a target peripheral capillary oxygen saturation (SpO ) range of 90-95% for preterm infants. These were incorporated into guidelines at the Karolinska University Hospital, Sweden, in November 2013. This study compared clinical practice before and after those local guidelines. Read More

Acta Paediatr 2019 Apr 5. Epub 2019 Apr 5.

Division of Emergency Medicine, Department of Women's and Children's Health, University of Padova, Padova, Italy.

Aim: This study aimed to determine the frequency of traumatic brain injury (TBI) on neuroimaging and the need for emergency neurosurgery in children with normal mental status following a post-traumatic seizure (PTS).

Methods: We searched six electronic databases from inception to 15 October 2018 to identify studies including children under 18 years with head injury and a Glasgow Coma Score of 15 after an immediate PTS. Relevant non-English articles were translated to determine eligibility. Read More

Acta Paediatr 2019 Apr 1. Epub 2019 Apr 1.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Aim: To determine the urinary tetranor-prostaglandin E metabolite in healthy infants and in hospitalized infants with upper and lower respiratory tract as well as gastrointestinal infections.

Methods: A prospective cross-sectional study to determine baseline concentrations of urinary tetranor-prostaglandin E metabolite was conducted in 81 healthy infants aged 1 week to 1 year and in 142 hospitalized infants with infections. Prostaglandin metabolite levels were measured by liquid chromatography tandem mass spectrometry. Read More

Acta Paediatr 2019 Apr 1. Epub 2019 Apr 1.

Department of Paediatrics, Copenhagen University Hospital, Rigshospitalet, Denmark.

Aim: We aimed at describing clinical findings in children with dyskinetic as compared to bilateral spastic cerebral palsy (CP).

Methods: Data was extracted from the Danish nationwide CP register. Participants were born in 1999-2007 and were 5-6 years at ascertainment. Read More

Acta Paediatr 2019 Apr 1. Epub 2019 Apr 1.

UCL Great Ormond Street Institute of Child Health, London, UK.

Acta Paediatr 2019 Mar 31. Epub 2019 Mar 31.

Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Naples, Italy.

Aim: Paediatric evidence about the clinical implications of enlarged abdominal lymph nodes (EALN) is not univocal. The main purpose of our study was to evaluate the clinical significance and the morphological evolution of enlarged abdominal nodes in children with recurrent abdominal pain.

Methods: All children with recurrent abdominal pain diagnosed with EALN were enrolled at the involved centres between September 2017 and June 2018. Read More

Acta Paediatr 2019 Mar 29. Epub 2019 Mar 29.

Norwegian Centre for Violence and Traumatic Stress Studies, Oslo, Norway.

Aim: The aim of the study was to compare parental satisfaction items before and after the implementation of The Ages & Stages Questionnaires (ASQ) as part of the health check-up.

Methods: ASQ was implemented in regular health check-ups of infants up to two years of age in 9 Norwegian well-baby clinics. After the infant's two years health check-ups, a questionnaire-based survey among 652 families before and 562 families after intervention was conducted. Read More

Acta Paediatr 2019 Mar 29. Epub 2019 Mar 29.

School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea.

Aim: To prospectively evaluate the use of bubble continuous positive airway pressure (CPAP) in children with very severe pneumonia and other acute lower respiratory infections, during its trial introduction in a low resource hospital in Papua New Guinea.

Methods: Prospective observational study of children treated with CPAP who had severe pneumonia and severe respiratory distress with hypoxaemia (SpO <90%). CPAP was driven by oxygen concentrators in which the fraction of inspired oxygen could be adjusted, and using low-resistance tubing and nasal oxygen prongs. Read More

Acta Paediatr 2019 Mar 29. Epub 2019 Mar 29.

School of Women's and Children's Heath, University of New South Wales, Sydney, NSW, Australia.

Aim: To validate the diagnostic discharge coding of Neonatal Abstinence Syndrome (NAS) (International Classification of Diseases (ICD)-10-AM, P96.1).

Methods: Retrospective record review of infants diagnosed with NAS (P96. Read More

Acta Paediatr 2019 Mar 29. Epub 2019 Mar 29.

Division of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Acta Paediatr 2019 Mar 29. Epub 2019 Mar 29.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Aim: Hirschsprung disease is usually treated during infancy. The long-term impact on mental health has not been well studied. The aim of this study was to assess the risk for depressive disorders in individuals with Hirschsprung disease. Read More

Acta Paediatr 2019 Mar 28. Epub 2019 Mar 28.

Centre for Child Health, Tampere University and University Hospital, Tampere, Finland.

Aim: This paper summarises variations in the genes encoding toll-like receptors (TLRs) in relation to the aetiology and outcome of infant bronchiolitis. It compares the literature with research carried out by our group.

Methods: A mini review was conducted to provide context for a study carried out at the Department of Paediatrics, Tampere University Hospital, Finland. Read More

Acta Paediatr 2019 Mar 28. Epub 2019 Mar 28.

End-of-Life Care Research Group, Ghent University & Vrije Universiteit Brussel (VUB), Brussel, Belgium.

Aim: Perinatal death is often preceded by an end-of-life decision (ELD). Disparate hospital policies, complex legal frameworks and ethically difficult cases make attitudes important. This study investigated attitudes of neonatologists and nurses towards perinatal ELDs. Read More

Acta Paediatr 2019 Mar 28. Epub 2019 Mar 28.

Section for Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Leukocytosis, namely a markedly elevated white blood cell (WBC) count, occurs in 1.3-17.0% of infants admitted to neonatal intensive care units and can be induced by infection, inflammation, stress or medication. Read More

Acta Paediatr 2019 Mar 27. Epub 2019 Mar 27.

Allergology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.

Acta Paediatr 2019 Mar 24. Epub 2019 Mar 24.

Professor of Psychiatry and Suicidology, National Centre for Suicide Research and Prevention of Mental lll-Health (NASP), Karolinska Institutet, Stockholm, Sweden.

Acta Paediatr 2019 Mar 22. Epub 2019 Mar 22.

PEDEGO Research Unit, University of Oulu, Oulu, Finland.

Aim: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is the most common cause of a periodic fever in childhood. The exact pathogenesis and the aetiology of PFAPA are still unknown.

Methods: We conducted a non-systematic review of published articles about PFAPA syndrome and summarised the evidence for diagnostic criteria and treatment options for PFAPA. Read More

Acta Paediatr 2019 Mar 22. Epub 2019 Mar 22.

Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

Failure to test children for human immunodeficiency virus (HIV) when they have HIV-positive mothers is common in both high-income and lower-income settings. Children who are older at the time of their mother's HIV diagnosis face a higher risk of not being tested (1). In low-resource environments, about 25% of vertically HIV-1 infected and untreated children may be expected to reach the age of 13 (2). Read More

Acta Paediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

Aim: Our aim was to compare the presence of various common viruses (rhinovirus, enterovirus, adenovirus, Epstein-Barr virus, cytomegalovirus, norovirus, parechovirus) in stool and nasal swab samples as well as virus-specific antibodies in serum samples between children who developed coeliac disease and controls.

Methods: A case-control study was established based on the DIABIMMUNE Study cohorts. During the study, eight Estonian children and 21 Finnish children aged 1. Read More

Acta Paediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Social work and Psychology, Faculty of Health and Occupational Studies, University of Gävle, Gävle, Sweden.

Aim: We examined if routine Swedish language screening for developmental language disorder (DLD) carried out at three years of age could be performed as effectively six months earlier.

Methods: This study observed 105 monolingual Swedish-speaking children (53% boys) aged 29-31 months at three Swedish child health centres. We compared their ability to combine three words, as per the existing protocol, and two words. Read More

Acta Paediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Neonatology, Rigshospitalet, Copenhagen, Denmark.

Aim: To evaluate gastrointestinal sequelae and growth impairment at school age in children who suffered from necrotising enterocolitis (NEC).

Methods: This historic cohort study compared all surviving children born in Denmark between 1 January 2002 and 31 December 2011 with NEC in the newborn period, to surviving children without NEC, but same gestational age, birthweight and year of birth. Outcomes were investigated through a parental questionnaire, including gastrointestinal and growth-related outcomes. Read More

Acta Paediatr 2019 Mar 21. Epub 2019 Mar 21.

Department of Social Work, Stockholm University, Stockholm, Sweden.

Aim: Parenting programmes tailored to immigrant parents have been reported to improve the mental health of the children and parents, as well as parents' sense of competence in parenting. However, research on parents' experiences of programmes tailored to their needs is scarce. This qualitative study aimed to describe Somali parents' experiences of how a culturally sensitive programme affected their parenting. Read More

Acta Paediatr 2019 Mar 21. Epub 2019 Mar 21.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Aim: Acute bacterial gastroenteritis is a major cause of morbidity and mortality, especially in the developing countries. We examined the incidence, clinical features and outcomes in the first week of life.

Methods: This was a retrospective study of culture-proven bacterial gastroenteritis in newborn infants that were diagnosed between January 2011 and September 2018 in a tertiary centre in Israel. Read More

Acta Paediatr 2019 Mar 19. Epub 2019 Mar 19.

Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Vic., Australia.

Aim: Brain alterations in very preterm children at risk for developmental coordination disorder were investigated.

Methods: Infants born very preterm with gestation age <30 weeks or birthweight <1250 g were recruited from Royal Women's Hospital Melbourne from 2001 to 2003. Volumetric imaging was performed at term equivalent age; at seven years, volumetric imaging and diffusion tensor imaging were performed. Read More

Acta Paediatr 2019 Mar 18. Epub 2019 Mar 18.

Allergology and Pulmonology Unit, 3rd Paediatric Department, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Aim: Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE)-mediated food allergy, which is confined to the gastrointestinal tract and occurs most frequently in the first year of life. Our aim was to examine the clinical features, causative agents and outcomes of Greek children with FPIES.

Methods: This was a five-year (2013-2017) retrospective study, based on chart reviews of 78 children with FPIES from six Greek paediatric allergy centres. Read More

Acta Paediatr 2019 Mar 18. Epub 2019 Mar 18.

Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Aim: To investigate whether motor performance in school-age children without cerebral palsy (CP), cooled for neonatal encephalopathy, is associated with perinatal factors and 18-month developmental scores and to explore relationships between school-age motor and cognitive performance.

Methods: Motor and cognitive performance was assessed in 29 previously cooled children at six to eight years using the Movement Assessment Battery for Children-2 (MABC-2) and the Wechsler Intelligence Scale for Children (WISC-IV). Associations between MABC-2 scores less than/equal (≤) 15th centile and perinatal factors, social/family background, 18-month Bayley-III scores and WISC-IV scores were explored. Read More

Acta Paediatr 2019 Mar 18. Epub 2019 Mar 18.

Department of Clinical Neurophysiology, Children's Hospital, University of Helsinki and Helsinki University Hospital (HUH), Helsinki, Finland.

Aim: General movement assessment requires substantial expertise for accurate visual interpretation. Our aim was to evaluate an automated pose estimation method, using conventional video records, to see if it could capture infant movements using objective biomarkers.

Methods: We selected archived videos from 21 infants aged eight to 17 weeks who had taken part in studies at the IRCCS Fondazione Stella Maris (Italy), from 2011 to 2017. Read More

Acta Paediatr 2019 Mar 18. Epub 2019 Mar 18.

The Children's Hospital Iceland, Landspítali - University Hospital, Reykjavik, Iceland.

Aim: Abdominal pain is a frequent reason for paediatric emergency department visits, but specific research is lacking. Our aim was to obtain information on the diagnosis of abdominal pain and what healthcare services children with this condition need.

Methods: This retrospective study focused on patients visiting the emergency department of the Children's Hospital Iceland in 2010 with abdominal pain and any subsequent visits up to 1 January 2015. Read More

Acta Paediatr 2019 Mar 13. Epub 2019 Mar 13.

Pediatrics Section, "Scuola Medica Salernitana", University of Salerno - Department of Medicine, Surgery and Dentistry, Baronissi (Salerno), Italy.

Acta Paediatr 2019 Apr;108(4):586-587

Department of Paediatrics, University of Gothenburg, Gothenburg, Sweden.

Acta Paediatr 2019 May 10;108(5):787-788. Epub 2019 Mar 10.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Acta Paediatr 2019 Mar 9. Epub 2019 Mar 9.

Clinical and Molecular Osteoporosis Research Unit, Departments of Orthopedics and Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

Acta Paediatr 2019 Mar 9. Epub 2019 Mar 9.

Neonatal Intensive Care Unit, CHRU de Tours, Tours, France.

Aim: The primary objective was to assess the effect of prematurity at term-equivalent age on skin conductance and behavioural responses to acute stress. The secondary objective was to explore the reliability of skin conductance in detecting neonatal discomfort in preterm and full-term populations.

Methods: Very preterm infants at term-equivalent age and healthy full-term neonates, 34 infants in each group, underwent the hip dysplasia screening test. Read More

Acta Paediatr 2019 Mar 8. Epub 2019 Mar 8.

Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden.

Haematohidrosis is a rare and dramatic condition in which bleeding occurs spontaneously from intact skin. We report the case of a nine-year-old boy with a typical clinical presentation. The case highlights how challenging it can be for medical professionals to recognise and evaluate rare conditions. Read More

Acta Paediatr 2019 Mar 7. Epub 2019 Mar 7.

Department of Children and Adolescents, Helsinki University Hospital, Helsinki, Finland.

Acta Paediatr 2019 Mar 6. Epub 2019 Mar 6.

Murdoch Children's Research Institute, Parkville, Vic., Australia.

Acta Paediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Aim: The study aims to investigate secular changes in adult height among Nordic reference populations during the last four decades and in parents of Swedish study participants, and to study during which growth phase(s) infancy, childhood or puberty changes in height and tempo occurred.

Methods: Length and height data were obtained from publications on populations used as current and previous national height references in Denmark, Finland, Norway and Sweden. Measurements from birth until adult height and original parental heights of participants in Swedish reference populations born 1956, 1974, and 1990 were used. Read More

Acta Paediatr 2019 Mar 5. Epub 2019 Mar 5.

Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR, USA.