Search Our Scientific Publications & Authors

Acta Paediatr 2019 Feb 14. Epub 2019 Feb 14.

Karolinska Institutet.

Aim: This paper integrates clinical expertise to earlier research about the behaviors of the healthy, alert, full-term infant placed skin-to-skin with the mother during the first hour after birth following a non-instrumental vaginal birth.

Method: This state-of-the-art article forms a link within the knowledge-to-action cycle, integrating clinical observations and practice with evidence-based findings to guide clinicians in their work to implement safe uninterrupted skin-to-skin contact the first hours after birth.

Results: Strong scientific research exists about the importance of skin-to-skin in the first hour after birth. Read More

Acta Paediatr 2019 Feb 12. Epub 2019 Feb 12.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Aim: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child.

Methods: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC ) mother-child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birth weights <2500g, resulting in 650 children analyzed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age. Read More

Acta Paediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Women's and Children's Health, Uppsala University.

Aim: We assessed whether early haemodynamically significant patent ductus arteriosus (hsPDA) predicted persistent PDA in extremely preterm infants.

Methods: This prospective observational study of 60 infants born at 22-27 weeks of gestational age without any major congenital anomalies or heart defects was conducted at Uppsala University Children's Hospital from November 2012 to May 2015. Respiratory and systemic circulatory parameters were continuously recorded and echocardiographic examinations performed daily during the first three days of life. Read More

Acta Paediatr 2019 Feb 11. Epub 2019 Feb 11.

Department of Women's and Children's Health, Neuropediatric Unit, Karolinska Institutet, Stockholm, Sweden.

Aim: This study examined the prevalence of neurological impairment and pituitary hormone deficiency (PHD) in patients with unilateral and bilateral optic nerve hypoplasia (ONH).

Methods: A population-based cross-sectional cohort study of 65 patients (51% female) with ONH was conducted in Stockholm. Of these were 35 bilateral and 30 unilateral. Read More

Acta Paediatr 2019 Feb 11. Epub 2019 Feb 11.

Institute of Sports Sciences and Physiotherapy, University of Tartu, 4 Ujula St, Tartu, 51 005, Estonia.

Aim: We explored the cognitive abilities, health behaviour and cardiorespiratory fitness of preschool Estonian children aged 6-7 and any association with parental education, attending sports clubs and gender.

Methods: Data were obtained from 256 children recruited from 13 randomly chosen kindergartens in Tartu, Estonia. Cognitive abilities were assessed using the modified Boehm Test of Basic Concepts - Third Edition. Read More

Acta Paediatr 2019 Feb 10. Epub 2019 Feb 10.

Section Head and Service Chief of Neonatology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.

Acta Paediatr 2019 Feb 8. Epub 2019 Feb 8.

University Children's Hospital of Saarland, Building 9, 66421, Homburg, Germany.

An ever-increasing body of data has demonstrated a close link between poverty and an increased risk for developing chronic non-communicable diseases and psychopathology. A study by Anand et al, published in Acta Paediatrica, studied the effects of socioeconomic adversity on the health on 1,503 pregnant girls and women aged 16-40 years without pregnancy complications or pre-existing conditions, including social, familial and economic factors. This article is protected by copyright. Read More

Acta Paediatr 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatric and Adolescent Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Norway.

Aim: The aim was to compare growth in very premature infants cared for in a single-family room and an open-bay unit. We recorded duration of parental presence and skin-to-skin contact as proxies for parental involvement in care of their infants.

Methods: We consecutively included infants with gestational ages 28+0 through 32+0 weeks at two hospitals in Norway, one single-family room unit (n=35) and one open-bay unit (n=42). Read More

Acta Paediatr 2019 Feb 5. Epub 2019 Feb 5.

Lund University, Department of Clinical Science, Lund, Pediatrics and Skåne University Hospital, Neonatology, Lund, Sweden.

Aim: Fentanyl pharmacokinetics and pharmacodynamics are lacking in preterm infants. Our aim was to study these and their relation with a new formulation of fentanyl 5μg/mL for procedural pain.

Methods: Preterm infants were given 0. Read More

Acta Paediatr 2019 Feb 5. Epub 2019 Feb 5.

Tergooi Hospital, Department of Paediatrics, Blaricum, Netherlands.

Aim: Our primary aim was to calculate the head computed tomography (CT) scan rate in children with a minor head injury (MHI) when the Dutch National guidelines were followed in clinical practice. The secondary aim was to determine the incidence of CT abnormalities and the guideline predictors associated with traumatic abnormalities.

Methods: We performed a multi-centre, prospective observational cross-sectional study in the emergency departments of six hospitals in The Netherlands between 1 April 2015 and 31 December 2016. Read More

Acta Paediatr 2019 Feb 5. Epub 2019 Feb 5.

Maine Medical Center, Portland, Maine.

Aim: Concerns for infant destabilization often prohibit parental holding of infants during therapeutic hypothermia (TH). We assessed the feasibility of maternal holding during TH, as the inability to hold can impede bonding.

Methods: Vital signs were assessed in stable infants before, at two-minute intervals during and 30 minutes after a single 30-minute holding session. Read More

Acta Paediatr 2019 Feb 5. Epub 2019 Feb 5.

Department of Neonatology, University Hospital of Nancy, Nancy, France.

In the past decade, multiple algorithmic models to predict various diseases of pathological severity have been the focus of the medical and scientific community. In the present context, WINROP is an incomplete model to identify preterm infants at high-risk to develop threshold retinopathy of prematurity (ROP) and needs to be improved from its current predictive parameters (1). ROP is a multifactorial disorder involving numerous pathophysiological processes including high inflammatory state, oxidative stress, disordered metabolic state and impaired angiogenesis. Read More

Acta Paediatr 2019 Feb 5. Epub 2019 Feb 5.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Aim: In parallel with falling smoking rates, use of the oral moist tobacco product snus increases among women in reproductive age. We report an update on prevalence and effects of maternal use of snus and nicotine replacement therapy (NRT) during pregnancy and breastfeeding.

Methods: A literature search of human studies in Medline, PubMed and EMBASE was conducted from September 2016 to May 2018, with stepwise screening of abstracts and subsequent relevant full text papers for inclusion in Scandinavian and English languages. Read More

Acta Paediatr 2019 Feb 4. Epub 2019 Feb 4.

Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Aim: Fever phobia describes exaggerated concerns about the consequences of childhood fever and broader awareness is needed in everyday clinical practice. We investigated the factors associated with fever phobia in caregivers and healthcare providers and the geographical distribution of the issue.

Methods: The National Library of Medicine and Excerpta Medica databases were searched for papers on fever phobia, excluding those that tackled fever phobia. Read More

Acta Paediatr 2019 Feb 4. Epub 2019 Feb 4.

Department of Neuroscience, Child and Adolescent Psychiatry Unit, Uppsala University, Uppsala, Sweden.

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by impairments in attention, hyperactivity and impulsivity. A higher proportion of boys than girls are diagnosed with ADHD, although girls seek care for ADHD at an older age, and almost to the same extent as men by adulthood (1). The sex difference in prevalence rates during childhood may hypothetically reflect a bias in referral patterns, where adults perceive and value girls' symptoms differently to boys' symptoms. Read More

Acta Paediatr 2019 Feb 4. Epub 2019 Feb 4.

Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA.

Shared decision-making (SDM) is the accepted standard for medical decision-making. It is a model that explicitly values input from both the clinical team and the patient or family. Patients and their surrogates vary in their preferences for participation in medical decision-making (1). Read More

Acta Paediatr 2019 Feb 3. Epub 2019 Feb 3.

Department of Pediatrics, The Queen Silvia Children's Hospital, University of Gothenburg, Gothenburg, Sweden.

Aim: We developed a new case presentation technique, SITUPS, and studied its impact on the patient presentations by medical students at a pediatric emergency department. The students' opinions about the usefulness of the technique were also assessed.

Methods: The students saw patients both before and after introduction to SITUPS. Read More

Acta Paediatr 2019 Feb 1. Epub 2019 Feb 1.

Newborn Research, Royal Women's Hospital, Melbourne, Victoria, Australia.

Aim: To develop a neonatal intervention score to describe the clinical trajectory of a neonate throughout their neonatal intensive care unit (NICU) admission.

Methods: The Neonatal Intervention Score (NIS) was developed by modifying the Neonatal Therapeutic Intervention Scoring System (NTISS) to reflect illness severity, dependency on life-sustaining interventions and overall life trajectory on a longitudinal basis, rather than illness burden. Validity for longitudinal use within the NICU was tested by calculating the score for 99 preterm babies born less than 28 weeks at predetermined time points throughout their admission to tertiary level care at two institutions. Read More

Acta Paediatr 2019 Feb 1. Epub 2019 Feb 1.

Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

Acta Paediatr 2019 Feb 1. Epub 2019 Feb 1.

Government Medical College Hospital, Chandigarh, India.

Acta Paediatr 2019 Jan 31. Epub 2019 Jan 31.

Grigore Alexandrescu Emergency Hospital for Children, Bucharest, Romania.

Aim: To evaluate how correct is made the diagnosis of autoimmune hepatitis (AIH) in children, comparing the adults scoring systems - the 1999 revised scoring system by International Autoimmune Hepatitis Group and the 2007 Simplified Scoring System. The inaccuracies in diagnosis have been analysed.

Methods: The two scoring systems have been applied for 28 children with AIH pre-treatment and 28 with Hepatitis B infection (HBV) - matched by sex and age, all diagnosed between 2010-2017 in an emergency children's hospital in Bucharest, Romania. Read More

Acta Paediatr 2019 Jan 31. Epub 2019 Jan 31.

Department of Psychiatry, Columbia University Medical Center, New York, New York.

Aim: The emotional connection between mothers and infants born preterm has been associated with positive behaviour. The aim of this study was to examine the longitudinal association between emotional connection at six months of age and behavioural problems at three years.

Methods: This study was carried out by the University of North Texas, USA and comprised 49 mothers and infants from a longitudinal investigation of family interaction and infant development conducted in 1994-1997. Read More

Acta Paediatr 2019 Jan 27. Epub 2019 Jan 27.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Aim: Acute Epstein-Barr virus (EBV) infection is a trigger of prolonged fatigue. This study investigated baseline predictors of physical activity six months after an acute EBV infection.

Methods: A total of 200 adolescents (12-20 years old) with acute EBV infection were assessed for 149 possible baseline predictors and followed prospectively. Read More

Acta Paediatr 2019 Jan 25. Epub 2019 Jan 25.

Department of Pediatrics, Sainte-Justine University Hospital Centre, University of Montreal, Montreal, QC, Canada.

Aim: To determine the relationship between neonatal phototherapy and future risk of clinically significant hemangioma.

Methods: We analysed a cohort of 678 879 infants born after 34 weeks gestation comprising 3 975 242 person-years of follow-up over 11 years (2006-2016). The exposure was phototherapy the first 28 days of life. Read More

Acta Paediatr 2019 Jan 22. Epub 2019 Jan 22.

University of Iceland, Faculty of Medicine.

Aim: The aim was to estimate the impact of the 10-valent pneumococcal vaccine (PHiD-CV) on tympanostomy tube placements (TTP) in children under five years of age in Iceland.

Methods: This population based observational cohort study followed 11 consecutive birth-cohorts 2005-2015 from birth until their fifth birthday. Population registries were merged using national identification numbers. Read More

Acta Paediatr 2019 Jan 21. Epub 2019 Jan 21.

RTI International - Biostatistics and Epidemiology, Rockville, MD, USA.

Acta Paediatr 2019 Jan 21. Epub 2019 Jan 21.

Department of Psychology and Division of Mental Health & Wellbeing, University of Warwick, University Road, Coventry, CV4 7AL, United Kingdom.

Aim: To evaluate the association of physical activity (PA) and forced expiratory volume in 1 second (FEV1), peak oxygen consumption (pVO2), body mass index (BMI) and body composition in preterm born individuals.

Methods: Cochrane Library, EMBASE, MEDLINE, AMED, ERIC, Web of Science and PsycInfo were searched with no restriction on language and date of publication from inception to January 2018. Data were extracted comparing preterm born individuals with different frequencies of PA and the outcome of interest. Read More

Acta Paediatr 2019 Jan 17. Epub 2019 Jan 17.

Chair and Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.

Aim: This Polish study estimated the prevalence of the Helicobacter pylori infection in symptomatic children aged 3-18 and investigated its association with gastrointestinal complaints.

Methods: We prospectively enrolled 1984 children (54% female) with a mean age of 9.5 ± 4. Read More

Acta Paediatr 2019 Jan 17. Epub 2019 Jan 17.

Neonatal Unit, Department of Paediatrics, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Acta Paediatr 2019 Jan 11. Epub 2019 Jan 11.

Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Netherlands.

Aim: Due to a lack of age-appropriate formulations, administration of drugs to children remains a challenge. This study aimed to identify the problems experienced in both the outpatient setting, as well as the clinical setting.

Methods: Between June 2017 and January 2018, we performed a cross-sectional, prospective study at the Sophia Children's Hospital, The Netherlands. Read More

Acta Paediatr 2019 Mar 9;108(3):570-571. Epub 2019 Jan 9.

Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Acta Paediatr 2019 Jan 7. Epub 2019 Jan 7.

Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg and Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

Aim: Clinical developmental phenotyping of four- to five-year-old children with febrile seizures (FSs).

Methods: Children with FS (n = 157, corresponding to 3.7% of the targeted general population of four-five-year-olds) had been identified at child healthcare centres in Gothenburg. Read More

Acta Paediatr 2019 Jan 7. Epub 2019 Jan 7.

Department of Newborn Care, The Royal Hospital for Women, Randwick, NSW, Australia.

Aim: To determine the relationship between clinical practice and publication of an Australian consensus statement for management of extremely preterm infants in 2006.

Methods: A population-based study using linked data from New South Wales, Australia for births between 22 + 0 and 26 + 6 weeks of gestation between 2000 and 2011.

Results: There were 4746 births of whom 2870 were liveborn and 1876 were stillborn. Read More

Acta Paediatr 2019 Jan 7. Epub 2019 Jan 7.

Department of Psychology, Stanford University School of Humanities& Sciences, San Francisco, CA, USA.

Aim: Early life adversity leads to enduring effects on physical and mental health, school performance and other outcomes. We sought to identify potentially modifiable factors associated with socioeconomic adversity in early life.

Methods: We enrolled 1503 pregnant women aged 16-40 years, without pregnancy complications or pre-existing conditions from Shelby County, Tennessee. Read More

Acta Paediatr 2019 Jan 7. Epub 2019 Jan 7.

Center for Child health Research, Tampere University Hospital, University of Tampere, Tampere, Finland.

Aim: Meta-analyses of randomised controlled trials on infant bronchiolitis do not support medication. We summarised the current data and evaluated the real-life use of medication for infants treated for bronchiolitis in hospitals, including paediatric wards, emergency departments and paediatric intensive care units (PICU).

Methods: We searched PubMed for studies published from 2009 to 2018 that provided data on the real-life use of adrenaline, salbutamol, corticosteroids or antibiotics for infants hospitalised for bronchiolitis. Read More

Acta Paediatr 2018 Dec 27. Epub 2018 Dec 27.

Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.

Acta Paediatr 2018 Dec 27. Epub 2018 Dec 27.

Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet and Child and Adolescent Psychiatry, Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

Aim: To study health-related quality of life (HRQoL) in children with idiopathic clubfoot (IC) and the influence of sex, clubfoot laterality and neurodevelopmental difficulties (NDD) on HRQoL.

Methods: A cross-sectional questionnaire-based study in Stockholm and Skåne Counties, Sweden, of 106 children with IC born 2004-2007 (mean 9.4 ± 0. Read More

Acta Paediatr 2018 Dec 27. Epub 2018 Dec 27.

Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK.

Acta Paediatr 2018 Dec 27. Epub 2018 Dec 27.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Aim: To systematically appraise and summarise published evidence on the association between childhood physical activity (PA) and subsequent age at menarche (AAM).

Methods: We searched PubMed (1990-2018) for studies that reported the relationship between childhood PA and AAM. We performed tabular synthesis of population-based studies and a random-effects meta-analysis of results of athlete/nonathlete studies. Read More

Acta Paediatr 2019 Mar 25;108(3):392-393. Epub 2018 Dec 25.

University of Geneva, Geneva, Switzerland.

Acta Paediatr 2019 Mar 25;108(3):575. Epub 2018 Dec 25.

Department of Pediatrics/Neonatology, Mansoura University Children's Hospital, Mansoura, Egypt.

Acta Paediatr 2018 Dec 24. Epub 2018 Dec 24.

International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Aim: This paper examines the change in neonatal resuscitation practices after the implementation of the Helping Babies Breathe (HBB) programme.

Methods: A systematic review was carried out on studies reporting the impact of HBB programmes among the literature found in Medline, POPLINE, LILACS, African Index Medicus, Cochrane, Web of Science and Index Medicus for the Eastern Mediterranean Region database. We selected clinical trials with randomised control, quasi-experimental and cross-sectional designs. Read More

Acta Paediatr 2018 Dec 24. Epub 2018 Dec 24.

Department of Anaesthesiology and Intensive Care, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Aim: This study described the basic characteristics of children aged 0-16 years who were treated in intensive care units (ICUs) and paediatric ICUs (PICUs), compared their outcomes and examined any causes of death.

Methods: This was a retrospective cohort study of admissions to 74 ICUs and three PICUs in Sweden that were recorded in the Swedish Intensive Care Registry from January 1, 2008 to December 31, 2012.

Results: We retrieved data on 12 756 children who were admitted 17 003 times. Read More

Acta Paediatr 2018 Dec 23. Epub 2018 Dec 23.

Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.

Aim: In 2017, the European Respiratory Society task force stated that protracted bacterial bronchitis (PBB) was a distinct clinical entity and outlined the diagnostic criteria and principles for treatment. However, this guidance was based on data from Australia and the USA. This mini review evaluated the data and addressed the lack of research-based data from Europe. Read More

Acta Paediatr 2019 Mar 21;108(3):394-395. Epub 2018 Dec 21.

Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Acta Paediatr 2019 Feb 21;108(2):383-384. Epub 2018 Dec 21.

Surya Hospitals, Mumbai, India.

Acta Paediatr 2018 Dec;107 Suppl 471:3-6

Department of Management of NCDs, Disability, Violence and Injury Prevention, World Health Organization, Geneva, Switzerland.

Acta Paediatr 2018 Dec;107 Suppl 471:63-71

Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland.

Aim: To assess the effect of enhanced supportive supervision of lady health workers (LHWs) by lady health supervisors on integrated community case management of childhood pneumonia and diarrhoea.

Methods: A total of thirty-four supervisors were randomly assigned to intervention and comparison arms. The intervention included enhanced training of supervisors on supervisory skills and written feedback to LHWs by supervisors. Read More

Acta Paediatr 2018 Dec;107 Suppl 471:7-16

Zhaojue Maternal and Child Care Service Centre, Zhaojue, China.

Aim: This study aimed to test a model which involved clans and health providers to increase antenatal care attendance in rural minority areas of China with high HIV prevalence.

Methods: Formative research was conducted to determine barriers and facilitators to antenatal care use. A strategy involving clans in addressing the barriers identified was developed. Read More