690,131 results match your criteria Acta Paediatrica[Journal]


A far-red-emitting fluorescence probe for selective and sensitive detection of no in live cells and in C. elegans.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 28;261:120030. Epub 2021 May 28.

Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. Electronic address:

Nitric oxide (NO), a ubiquitous intracellular and intercellular messenger molecule, plays vital roles in many physiological processes and is closely related to many diseases. Although a lot of fluorescent probes have been developed for real-time detection of NO successfully, the probes still suffer from poor tissue permeability and limited selectivity. In this study, a novel far-red fluorescent probe ZJL-3 based on rhodamine fluorescent dye was designed, synthesized, and used for NO determination. Read More

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AIE-based fluorescent boronate probe and its application in peroxynitrite imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 4;261:120044. Epub 2021 Jun 4.

Institute of Environmental Science, Shanxi University, Taiyuan 030006, PR China. Electronic address:

Fluorescent probes have contributed greatly to our understanding of the biological role of peroxynitrite (ONOO). The ONOO fluorescence probe characterized by the arlyboronate received a moderate opening fluorescence response, and the borate-masked probe significantly increased the sensitivity of ONOO. Thus, two simple fluorescent probes (ADB and ANB) with the recognition receptor of phenyl boronate moiety were constructed for the detection of ONOO. Read More

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CuS nanoparticles-enhanced luminol-O chemiluminescence reaction used for determination of paracetamol and vancomycin.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 1;261:120038. Epub 2021 Jun 1.

Department of Chemistry, College of Science, Sultan Qaboos University, Box 36, Al-Khod, 123, Oman.

A new chemiluminescence (CL) method was proposed to measure two widely used drugs, including paracetamol (PCM) and vancomycin (VAN). The CL reaction used was the CuS nanoparticles (CuS NPs)-luminol-O system. In this system, CuS NPs played the role of catalyst and increased the CL intensity. Read More

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Harnessing Biomaterials for Lymphatic System Modulation.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

Bioengineering Graduate Program, University of Notre Dame, Notre Dame, IN 46556; Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556; Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556. Electronic address:

The lymphatic system plays an integral part in regulating immune cell trafficking and the transport of macromolecules. However, its influence on disease progression and drug uptake is understood less than that of the vascular system. To bridge this knowledge gap, biomaterials can be used to investigate the lymphatic system and to provide novel understanding into complex disease processes, including cancer metastasis and inflammation. Read More

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Combining tunable proteolytic sequences and a VEGF-mimetic peptide for the spatiotemporal control of angiogenesis within Elastin-Like Recombinamer scaffolds.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

G.I.R. BIOFORGE (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, Edificio LUCIA, Universidad de Valladolid, Paseo Belén 19, 47011 Valladolid, Spain. Electronic address:

One of the main challenges in regenerative medicine is the spatiotemporal control of angiogenesis, which is key for the successful repair of many tissues, and determines the proper integration of the implant through the generation of a functional vascular network. To this end, we have designed a three-dimensional (3D) model consisting of a coaxial binary elastin-like recombinamer (ELR) tubular construct. It displays fast and slow proteolytic hydrogels on its inner and outer part, respectively, both sensitive to the urokinase plasminogen activator protease. Read More

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A biomimetic triple-layered biocomposite with effective multifunction for dura repair.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China. Electronic address:

Dura mater defect and subsequent cerebrospinal fluid (CSF) leakage usually appear in trauma or neurosurgical procedures and are followed by a series of serious complications and even death. The use of a qualified dura mater substitute with multifunction of leakage blockade, adhesion prevention, and dura reconstruction is one of the promising treatment methods. However, even though some products have been used in the clinic, none of the substitutes achieved the required multifunction. Read More

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A review of the physiological impact of rare earth elements and their uses in biomedical Mg alloys.

Acta Biomater 2021 Jun 9. Epub 2021 Jun 9.

School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia.

Magnesium (Mg) is well-tolerated by the body, displaying exceedingly low toxicity, rapid excretion, and numerous bioactive effects, including improved bone formation and protection against oxidative stresses; further, Mg alloys can be degraded in vivo to allow complete removal of an implant without surgical intervention, avoiding revision surgery and thrombosis concerns seen with permanent implants. Rare earth elements (REEs) have been of particular interest in alloying Mg alloys for nearly a century due to their unique chemical and physical properties but have attracted increasing attention in recent decades. The REEs contribute greatly to the mechanical and biological properties of metal alloys, and so are common in Mg alloys in a wide variety of applications; in particular, they represent the dominant alloying additions in current, clinically applied Mg alloys. Read More

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Sec14 family of lipid transfer proteins in yeasts.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Jun 9:158990. Epub 2021 Jun 9.

Institute of Animal Biochemistry and Genetics, Centre of Biosciences, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address:

The hydrophobicity of lipids prevents their free movement across the cytoplasm. To achieve highly heterogeneous and precisely regulated lipid distribution in different cellular membranes, lipids are transported by lipid transfer proteins (LTPs) in addition to their transport by vesicles. Sec14 family is one of the most extensively studied groups of LTPs. Read More

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Cellular cholesterol and how to find it.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Jun 9:158989. Epub 2021 Jun 9.

Heidelberg University Biochemistry Center (BZH), 69120 Heidelberg, Germany. Electronic address:

Cholesterol is an essential component of eukaryotic cellular membranes. Information about its subcellular localization and transport pathways inside cells are key for the understanding and treatment of cholesterol-related diseases. In this review we give an overview over the most commonly used methods that contributed to our current understanding of subcellular cholesterol localization and transport routes. Read More

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Pregnancy and Viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.

Biochim Biophys Acta Mol Basis Dis 2021 Jun 9:166198. Epub 2021 Jun 9.

Fetal and Perinatal Medicine and Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant - "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.

Some maternal infections, contracted before or during pregnancy, can be transmitted to the fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) and through breastfeeding (postnatal infection). The agents responsible for these infections can be viruses, bacteria, protozoa, fungi. Among the viruses most frequently responsible for congenital infections are Cytomegalovirus (CMV), Herpes simplex 1-2, Herpes virus 6, Varicella zoster. Read More

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Light chain subunit of a poorly soluble human IgG2λ crystallizes in physiological pH environment both in cellulo and in vitro.

Biochim Biophys Acta Mol Cell Res 2021 Jun 9:119078. Epub 2021 Jun 9.

Department of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA 91320, USA.

Prominent inclusion bodies can develop in the endoplasmic reticulum (ER) when overexpressed antibodies possess intrinsically high condensation propensities. These observations suggest that antibodies deemed to show notable solubility problems may reveal such characteristics preemptively in the form of ER-associated inclusion bodies during antibody overexpression. To define the relationships between solubility problems and inclusion body phenotypes, we investigated the biosynthesis of a model human IgG2λ that shows severe opalescence in an acidic formulation buffer yet retains high solubility at physiological pH. Read More

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Syringe irrigation in minimally-shaped root canals using three endodontic needles: a Computational Fluid Dynamics study.

J Endod 2021 Jun 9. Epub 2021 Jun 9.

Department of Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction: The aim of this study was to compare the irrigant flow in curved root canals prepared to various apical sizes by constant-taper or variable-taper instruments during syringe irrigation with three endodontic needles at two different flow rates.

Methods: Two matched curved mesial root canals of human mandibular molars were imaged by micro-computed tomography after preparation to apical size 20, 25, and 30/.06 taper either by constant-taper or variable-taper instruments. Read More

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Small dense low-density lipoprotein: analytical review.

Clin Chim Acta 2021 Jun 9. Epub 2021 Jun 9.

Department of Clinical Biochemistry, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, Scotland, United Kingdom. Electronic address:

Background: The causal relationship between low-density lipoprotein (LDL) and atherosclerotic cardiovascular disease (CVD) has been firmly substantiated. LDL consists of a heterogeneous group of particles with different physicochemical and metabolic properties. Among them, small dense LDL (sdLDL) particles are considered an emerging CVD risk factor and a promising CVD risk biomarker. Read More

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Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors.

Clin Chim Acta 2021 Jun 9. Epub 2021 Jun 9.

Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, DK-4000 Roskilde, Denmark.

Background And Aims: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim of this study was to explore the long-term association between AR, AC, asthma, and specific immunoglobulin E (IgE) and blood platelet and leukocyte differential counts.

Material And Methods: In the Danish Blood Donor Study, 14,440 participants from Central Denmark Region had platelet and leukocyte differential counts available and completed a questionnaire regarding AR, AC, and asthma. Read More

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Nonlinear material and ionic transport through membrane nanotubes.

Biochim Biophys Acta Biomembr 2021 Jun 9:183677. Epub 2021 Jun 9.

Biofisika Institute (CSIC, UPV/EHU), University of the Basque Country, barrio Sarriena s/n, 48940 Leioa, Spain; Department of Biochemistry and Molecular Biology, University of the Basque Country, barrio Sarriena s/n, 48940 Leioa, Spain; Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3, 6 solairua, 48013 Bilbao, Spain. Electronic address:

Membrane nanotubes (NTs) and their networks play an important role in intracellular membrane transport and intercellular communications. The transport characteristics of the NT lumen resemble those of conventional solid-state nanopores. However, unlike the rigid pores, the soft membrane wall of the NT can be deformed by forces driving the transport through the NT lumen. Read More

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Association between ocular toxoplasmosis and APEX1 and MYD88 polymorphism.

Acta Trop 2021 Jun 9:106006. Epub 2021 Jun 9.

Laboratory of Biology of Malaria and Toxoplasmosis, Department of Parasitology, Center for Biosciences, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address:

Ocular toxoplasmosis (OT) is the most common form of posterior uveitis, and in some countries, it is the most frequent cause of visual impairment. Studies demonstrate that the polymorphism in genes involved with the immune response can be related both to the occurrence and to the recurrence of OT. Thus, the present study aimed to analyze the association between OT and the polymorphism of the APEX1 (rs1130409) and MyD88 (rs7744) genes. Read More

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Clinico-microbiological description and evaluation of rapid lateral flow immunoassay and PCR for detection of Burkholderia pseudomallei from patients hospitalized with sepsis and pneumonia: A twenty-one months study from Odisha, India.

Acta Trop 2021 Jun 9:105994. Epub 2021 Jun 9.

Department of Community and Family Medicine, AIIMS, Bhubaneswar. Electronic address:

Establishing a diagnosis of melioidosis based on clinical grounds is difficult in hospitalized patients with sepsis or community acquired pneumonia (CAP). We aimed to ascertain the prevalence, clinico-epidemiological and laboratory profile of melioidosis in hospitalized patients with sepsis or CAP, and to evaluate the diagnostic utility of rapid lateral flow immunoassay (LFI) and PCR in comparison with culture. In all patients with sepsis or CAP, blood, sputum/throat swab, and urine sample were subjected to culture along with other samples based on clinical presentation. Read More

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Discovery and Validation of a Novel Target of Molluscicides against Oncomelania hupensis, the Intermediate Host of Schistosoma japonicum.

Acta Trop 2021 Jun 9:106003. Epub 2021 Jun 9.

School of Pharmaceutical Science, Jiangnan University,Wuxi, Jiangsu,214122, China. Electronic address:

In this study, 196 strains of actinomycetes isolated from marshland soil samples were tested for molluscicidal activity against Oncomelania hupensis. Five strains demonstrated molluscicidal activity, of which the molluscicidal efficiency of Actinomycetes strain A183 was the maximum. After the fermentation supernatant of actinomycetes A183 was extracted with ethyl acetate (EWEA), the LC50 of the EWEA after leaching for 48 h and 72 h were 0. Read More

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Intra and peridomiciliary comparison of density, sex ratio and gonotrophic stage of Phlebotomus sergenti in an active anthroponotic cutaneous leishmaniasis focus in Morocco.

Acta Trop 2021 Jun 9:106005. Epub 2021 Jun 9.

Department of Parasitology, Faculty of Pharmacy, University of Granada, Spain.

Cutaneous leishmaniasis due to Leishmania tropica represents a major public health problem due to its ability to spread into non-endemic areas by means of its vectors, and the associated dramatic psychosocial impact. The objective of this work was to compare the intra and extradomiciliary density, sex ratio and gonotrophic stage of sand flies from a recent active focus in Morocco. This field study is based on the need to optimize the effectiveness of control programs. Read More

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Unmet need for evidence of volume-outcome relation and maternal outcomes of placenta accreta spectrum.

Acta Obstet Gynecol Scand 2021 Jun 12. Epub 2021 Jun 12.

Department of Gynecology, Osaka International Cancer Institute, Osaka, Japan.

We read the study by Nieto-Calvache et al. with great interest, that examined the causes of death related to placenta accreta spectrum (PAS) and analyzed the associated diagnostic and treatment problems in low and middle income countries. The authors concluded that lack of experience and inadequate surgical technique are the most frequent problems associated with maternal deaths in PAS. Read More

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Description of the Metacercaria of Cardiocephaloides sp. (Digenea, Diplostomoidea), Newly Recorded from the Brain of Gangetic Leaffish (Nandus nandus) and Its Genetic Characterization in India.

Acta Parasitol 2021 Jun 12. Epub 2021 Jun 12.

Molecular Taxonomy Laboratory, Department of Zoology, Chaudhary Charan Singh University, Meerut, 250004, UP, India.

Purpose: Cardiocephaloides comprises strigeid trematodes that represent a small genus. In this study, metacercaria identified as Cardiocephaloides sp. was collected from the Gangetic leaffish Nandus nandus from the Ganga River at Bairaj, Bijnor (29º01'N, 77º45'E) in the state of Uttar Pradesh (U. Read More

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Perylene diimide/MXene-modified graphitic pencil electrode-based electrochemical sensor for dopamine detection.

Mikrochim Acta 2021 Jun 12;188(7):230. Epub 2021 Jun 12.

Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore, 54000, Pakistan.

The synthesis of novel architecture comprising perylene diimide (PDI)-MXene (TiCT)-integrated graphitic pencil electrode for electrochemical detection of dopamine (DA) is reported. The good electron passage between PDI-MXene resulted in an unprecedented nano-adduct bearing enhanced electrocatalytic activity with low-energy electronic transitions. The anionic groups of PDI corroborated enhanced active surface area for selective binding and robust oxidation of DA, thereby decreasing the applied potential. Read More

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The effects of 2-aminoethoxydiphenyl borate and dantrolene on rat bones treated with NaAsO2.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar 1. Epub 2021 Mar 1.

Department of Ultrasonography, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832008, China.

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FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.

Acta Biochim Biophys Sin (Shanghai) 2021 Jun 12. Epub 2021 Jun 12.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200031, China.

Fibroblast growth factor-binding protein 1 (FGFBP1) promotes fibroblast growth factor (FGF) activity by releasing FGFs from extracellular matrix storage. We previously reported that the tumor suppressor F-box and WD repeat domain-containing 7 suppresses FGFBP1 by reducing expression of c-Myc, which inhibits the proliferation and migration of pancreatic cancer cells. However, the potential mechanism by which FGFBP1 facilitates pancreatic ductal adenocarcinoma (PDAC) remains unexplored. Read More

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Complications in stereoelectroencephalography: are we too severe?

Acta Neurochir (Wien) 2021 Jun 11. Epub 2021 Jun 11.

Centre of Epilepsy Surgery "C. Munari", Department of Neuroscience, Niguarda Hospital, Piazza dell'Ospedale Maggiore 3, 20162, Milan, Italy.

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ZIF-based boronic acid functionalized metal-organic frameworks for the enrichment of cis-diol-containing luteolin from food samples prior to  HPLC.

Mikrochim Acta 2021 Jun 11;188(7):229. Epub 2021 Jun 11.

Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, People's Republic of China.

Zeolite imidazole framework-based boronic acid-functionalized metal-organic frameworks ([email protected]@BA-Zr-MOFs) were developed as an adsorbent for solid phase extraction (SPE) of luteolin (LTL) from peanut shell samples. Herein, ZIF-67 as a support matrix, polydopamine (PDA) as a coating to introduce amino and hydroxyl groups on the matrix surface to fix metal-organic frameworks (MOFs), zirconium tetrachloride (ZrCl) as a precursor, terephthalic acid (TPA), and 3-carboxyphenylboronic acid (3-CPBA) as the mutual organic building blocks, and 3-CPBA was also a boronate affinity functional monomer. The effects of synthesis conditions, SPE conditions, selectivity, competitivity, reproducibility, and reusability were evaluated in detail. Read More

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Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG-1 expression.

Acta Pharmacol Sin 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Hepatocellular carcinoma (HCC), the most prevalent liver cancer, is considered one of the most lethal malignancies with a dismal outcome mainly due to frequent intrahepatic and distant metastasis. In the present study, we demonstrated that oroxylin A, a natural product extracted from Scutellaria radix, significantly inhibits transforming growth factor-beta1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) and metastasis in HCC. Oroxylin A blocked the TGF-β1/Smad signaling via upregulating the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) expression. Read More

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Judging me and you: Task design modulates self-prioritization.

Acta Psychol (Amst) 2021 Jun 8;218:103350. Epub 2021 Jun 8.

School of Psychology, University of Aberdeen, Aberdeen, Scotland, UK.

An extensive literature has revealed the benefits of self-relevance during stimulus processing. Compared to material associated with other persons (e.g. Read More

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A highly selective and sensitive Zn fluorescent sensor based on zinc finger-like peptide and its application in cell imaging.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 2;261:120042. Epub 2021 Jun 2.

School of Chemistry and Chemical Engineering, University of South China, Hengyang, China. Electronic address:

Developing new chemosensors for detection of Zn has attracted great attentions because of the important roles of Zn in biological systems, and it will produce toxic effects with an excessive intake of zinc ion. Metalloproteins are often used as an effective template for the design and development of peptide-based fluorescent sensors. In this study, we designed a new and simple ratiometric fluorescent sensor for Zn, which was based on a zinc finger-like peptide and labeled with a dansyl group, i. Read More

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