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    8131 results match your criteria Acta Ophthalmologica[Journal]

    1 OF 163

    ATP-binding cassette subfamily A, member 4 intronic variants c.4773+3A>G and c.5461-10T>C cause Stargardt disease due to defective splicing.
    Acta Ophthalmol 2018 Feb 20. Epub 2018 Feb 20.
    Medical Biosciences/Medical and Clinical Genetics, University of Umeå, Umeå, Sweden.
    Purpose: Inherited retinal dystrophies (IRDs) represent a group of progressive conditions affecting the retina. There is a great genetic heterogeneity causing IRDs, and to date, more than 260 genes are associated with IRDs. Stargardt disease, type 1 (STGD1) or macular degeneration with flecks, STGD1 represents a disease with early onset, central visual impairment, frequent appearance of yellowish flecks and mutations in the ATP-binding cassette subfamily A, member 4 (ABCA4) gene. Read More

    Spectacle use after routine cataract surgery and vision-related activity limitation.
    Acta Ophthalmol 2018 Feb 20. Epub 2018 Feb 20.
    St. Erik Eye Hospital, Department of Clinical Neuroscience, Division of Ophthalmology and Vision, Karolinska Institutet, Stockholm, Sweden.
    Purpose: To explore the relationship between acquisition of new spectacles after routine cataract surgery and vision-related activity limitation (VRAL) postoperatively.

    Methods: This cohort study with intervention (survey) included 1329 patients in Sweden who had undergone a second-eye cataract surgery during March 2013. Data from the Swedish National Cataract Register were used, including evaluations of VRAL through the Catquest-9SF questionnaire before and 3 months after cataract surgery. Read More

    The relation between dietary intake and glaucoma: a systematic review.
    Acta Ophthalmol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Ophthalmology, Maastricht University Medical Center, Maastricht, The Netherlands.
    Purpose: A common question of patients to their physician is what they can do themselves against glaucoma, except taking their daily medication. However, for ophthalmologists, it is often hard to give their patients an advice on their dietary intake. To help ophthalmologists in answering this question, an overview of the current scientific literature on the association of nutrients with glaucoma is presented. Read More

    Improving eye care services with a lean approach.
    Acta Ophthalmol 2018 Feb 20. Epub 2018 Feb 20.
    Unit of Ophthalmology, Kymenlaakso Central Hospital, Kotka, Finland.
    Purpose: Effective provision of eye care services in government-financed hospitals is essential to balance the discrepancy between growing demand and limited resources. We aimed to improve efficiency of the treatment protocol for Nd:YAG laser posterior capsulotomy. Predetermined quality targets were a patient-oriented and patient-safe approach and the development of a clinical care process with purposeful use of competences. Read More

    Risk factors for postoperative intraretinal cystoid changes after peeling of idiopathic epiretinal membranes among patients randomized for balanced salt solution and air-tamponade.
    Acta Ophthalmol 2018 Feb 20. Epub 2018 Feb 20.
    VIROS - Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.
    Purpose: Epiretinal membranes (ERM) are macular disorders leading to loss of vision and metamorphopsia. Vitrectomy with membrane peeling displays the gold standard of care. Aim of this study was to assess risk factors for postoperative intraretinal cystoid changes in a study population randomized for balanced salt solution and air-tamponade at the end of surgery. Read More

    Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma.
    Acta Ophthalmol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Ophthalmology, Rigshospitalet-Glostrup, Glostrup, Denmark.
    Purpose: Lacrimal gland tumours constitute a wide spectrum of neoplastic lesions that are histologically similar to tumours of the salivary gland. In the salivary gland, pleomorphic adenoma (PA) is frequently characterized by recurrent chromosomal rearrangements of the PLAG1 and HMGA2 genes, a genetic feature retained in carcinoma ex pleomorphic adenoma (ca-ex-PA) that makes it possible to distinguish ca-ex-PA from de novo carcinomas. However, whether PLAG1 and HMGA2 gene rearrangements are found in lacrimal gland PA and ca-ex-PA is not known. Read More

    Long-term visual outcome in a Danish population of patients with idiopathic intracranial hypertension.
    Acta Ophthalmol 2018 Feb 6. Epub 2018 Feb 6.
    Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Purpose: Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure (ICP), normal cerebrospinal composition and exclusion of alternative causes to increased ICP. The aim of this study was to evaluate long-term visual outcome in a Danish population of IIH patients.

    Methods: Retrospective chart review of 41 women diagnosed with IIH between June 2007 and March 2013. Read More

    Pulmonary safety of ophthalmic beta-blockers: a nationwide registry-based cohort study.
    Acta Ophthalmol 2018 Feb 1. Epub 2018 Feb 1.
    Department of Ophthalmology, Aalborg University Hospital, Aalborg, Denmark.
    Purpose: Ophthalmic beta-blockers, used in the treatment of increased intraocular pressure, are known to cause pulmonary adverse effects. Few, if any, studies have quantified the extent of the problem in a real-life population. In this nationwide study, we assess the pulmonary safety of patients initiating treatment with ophthalmic beta-blockers. Read More

    Nitinol basket-assisted pars plana vitrectomy for retained lens material removal.
    Acta Ophthalmol 2018 Feb 1. Epub 2018 Feb 1.
    Department of Ophthalmology, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.
    Purpose: To evaluate the usefulness of different types of nitinol baskets to capture, lift and hold the lens material, dropped during a complicated phacoemulsification, as an adjunctive surgical tool in vitreoretinal surgery and to evaluate the outcomes and complication of this new surgical technique in a small series of patients.

    Methods: Patients who underwent pars plana vitrectomy (PPV) for retained lens fragments operated during December 2014 and March 2015 at the Academic Medical Center (AMC), Amsterdam, were included in this study. The PPV was performed using different settings and types of nitinol stone extractors (NSE). Read More

    Intravitreal diclofenac for treatment of refractory uveitis-associated cystoid macular oedema: A before and after clinical study.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Faculty of medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Cystoid macular oedema (CME) is one of the important complications of uveitis leading to irreversible blindness. Currently, there is no gold standard treatment for this condition. The aim of this study was to investigate the effects of single intravitreal diclofenac (IVD) injection on short-term outcome of refractory uveitis-associated CME. Read More

    Long-term uveal melanoma survivors: measuring their quality of life.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Purpose: Patients with uveal melanoma (UM) undergo lifelong follow-up as metastases can occur more than 20 years after diagnosis. Little is known about the quality of life (QoL) of UM survivors over such an extended period. To investigate their QoL, we used various estimating factors. Read More

    Long-term uveal and capsular biocompatibility of a novel modular intraocular lens system.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
    Background: We evaluated the long-term biocompatibility and safety of a new modular posterior chamber intraocular lens (IOL) system in rabbit eyes.

    Methods: Seven New Zealand rabbits underwent bilateral phacoemulsification with placement of the modular IOL in OD and a control IOL (SA60AT) in OS. Slit-lamp examinations were performed at postoperative weeks 1, 2, 3, 4, 6 and 8 and months 3 and 6. Read More

    Autoimmunity in uveitis.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Department of Ophthalmology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
    Purpose: Recent insights into the pathogenesis of immune-mediated diseases proposed a new classification, which includes autoimmune and auto-inflammatory diseases. The prevalence of specific autoimmune and auto-inflammatory diseases in uveitis and/or scleritis is not yet known. In this study, we examine the presence of systemic immune-mediated diseases in patients with uveitis and/or scleritis and put a special emphasis on autoimmune disorders by reporting on their clinical manifestations and visual prognosis. Read More

    Increased endothelin-1-mediated vasoconstriction after organ culture in rat and pig ocular arteries can be suppressed with MEK/ERK1/2 inhibitors.
    Acta Ophthalmol 2018 01 25. Epub 2018 Jan 25.
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden.
    Purpose: Even though retinal vascular changes following ischaemia have been poorly understood, the upregulation of vasoconstrictive endothelin-1 (ET-1) receptors (ET/ET) following global cerebral ischaemia has been described. The aim of this study was to investigate whether or not the MEK/ERK1/2 pathway is involved in the observed upregulation and whether specific MEK/ERK1/2 inhibitors U0126 and trametinib can prevent it.

    Methods: The aim was also to localize ETand ETreceptors using immunohistochemistry in both fresh rat ophthalmic arteries and after 24-hr organ culture and study the receptors functionally using myography. Read More

    Ophthalmological data on 4.5- to 7-year-old Danish children.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Eye Department, Zealand University Hospital, Roskilde, Denmark.
    Purpose: To report normative data on visual acuity (VA) for near and distance, refraction, ocular alignment, ocular motility and stereo acuity in a cohort of children aged 4.5-7 years.

    Methods: A total of 950 children with normal development from the municipality of Roskilde, Denmark, were invited to participate in an ophthalmic cross-sectional population-based survey, of which 445 children in the age of 54-87 months participated with a complete ocular examination including cycloplegia. Read More

    Anti-inflammatory medication following cataract surgery: a randomized trial between preservative-free dexamethasone, diclofenac and their combination.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.
    Purpose: To examine the anti-inflammatory efficacy and tolerance between preservative-free dexamethasone (DEX) and diclofenac (DICL) eye drops, and their combination following cataract surgery.

    Methods: A randomized, double-blind, prospective single-centre study with 189 eyes of 180 patients undergoing routine cataract surgery. Laser flare meter measurement and spectral-domain optical coherence tomography imaging were conducted before surgery and at the 28-day postoperative visit. Read More

    Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Department of Ophthalmology, Maastricht University Medical Center+, Maastricht, The Netherlands.
    Purpose: To calculate the prevalence of all vitreomacular interface (VMI) disorders and stratify according to age, sex and (pre)diabetes status.

    Methods: The presence of VMI disorders was assessed in 2660 participants aged between 40 and 75 years from The Maastricht Study who had a gradable macular spectral-domain optical coherence tomography (SD-OCT) volume scan in at least one eye [mean 59.7 ± 8. Read More

    Age-related changes in with-the-rule and oblique corneal astigmatism.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Randers Regions Hospital, Randers, Denmark.
    Purpose: To describe the age-related changes in with-the-rule (WTR) and oblique keratometric astigmatism (KA), posterior corneal astigmatism (PCA) and total corneal astigmatism (TCA).

    Methods: We used a Pentacam HR (high-resolution) rotating Scheimpflug camera to determine the KA, PCA and TCA in the right eyes of 710 patients, aged from 20 to 88 years. The age-related changes along the vertical, horizontal and oblique meridians were analyzed with Naeser's polar value method in a cross-sectional study. Read More

    Diabetic retinopathy in type 1 diabetes patients in Western Norway.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Department of Clinical Medicine, Section of Ophthalmology, University of Bergen, Bergen, Norway.
    Purpose: To describe the prevalence of diabetic retinopathy (DR), associated risk factors and health-related quality of life (HRQoL) in a population-based cohort of patients with type 1 diabetes mellitus (DM1).

    Methods: All patients underwent a general and ophthalmic examination including seven-field stereo fundus photography for grading of DR and diabetic macular oedema (DMO). Kaplan-Meier survival analyses were performed to evaluate disease progression in relation to diabetes duration, age and year of diabetes onset. Read More

    Age-related change and sex difference over 60s in disc-fovea angle in Japanese population: the Nagahama Study.
    Acta Ophthalmol 2018 Jan 25. Epub 2018 Jan 25.
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Purpose: To analyse the disc-fovea angle (DFA) by age group and to compare sex differences in each age group in a large cohort population.

    Methods: This community-based cross-sectional cohort study included 9682 eyes of 9682 volunteers (aged 30-75 years). We measured the DFA, which is the angle between a horizontal line and a line connecting the fovea with the centroid of an optic disc on fundus photographs of the right eye. Read More

    Choroidal thickness at age 66 years in the Danish high myopia study cohort 1948 compared with follow-up data on visual acuity over 40 years: a clinical update adding spectral domain optical coherence tomography.
    Acta Ophthalmol 2018 Feb;96(1):46-50
    Danish Myopia Institute, Espergaerde, Denmark.
    Background And Purpose: A population-based Copenhagen birth year 1948 cohort with high myopia recorded since age 14 years (spherical equivalent less than or equivalent to -6 D) has been followed over 50 years. Despite complications, current follow-ups have outlined a better visual prognosis than usually drawn from selected clinical series in the literature. For the present status at age 66 years, focus was on visual ability and choroidal thickness. Read More

    Phacoemulsification and primary implantation with bag-in-the-lens intraocular lens in children with unilateral and bilateral cataract.
    Acta Ophthalmol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Clinical Neuroscience/Ophthalmology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
    Purpose: To report outcome in a paediatric cohort with cataract extraction and implantation of bag-in-the-lens intraocular lens (BIL-IOL).

    Methods: Children younger than 16 years of age subjected to phacoemulsification with primary implantation of BIL-IOL during 2009 through 2013 were analysed retrospectively. Exclusion criteria were uveitis or ≤6 months of follow-up. Read More

    Retinal oximetry is affected in multiple sclerosis.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    University of Iceland, Reykjavik, Iceland.
    Purpose: Structural and physiological abnormalities have been reported in the retina in patients with multiple sclerosis (MS). Retinal oximetry has recently detected changes in retinal oxygen metabolism in Alzheimer's disease and mild cognitive impairment. Our goal was to determine whether oxygen saturation in retinal blood vessels of patients with patients is different from that of a healthy population. Read More

    Pimasertib-associated ophthalmological adverse events.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Ophthalmology, Leiden University Medical Centre, Leiden, the Netherlands.
    Purpose: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM).

    Methods: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT). Read More

    Tumour thickness, diameter, area or volume? The prognostic significance of conventional versus digital image analysis-based size estimation methods in uveal melanoma.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Ophthalmic Pathology and Oncology Service, St. Erik Eye Hospital, Stockholm, Sweden.
    Purpose: The aim of this study was to compare conventional and novel size estimation methods' ability to predict survival in uveal melanoma (UM).

    Methods: The study was designed as a retrospective consecutive chart review of patients with UM, enucleated between the years 1984 and 1993. Area and volume were estimated based on the largest histopathological cross-section, the second centroid theorem of Pappus and digital image analysis, correlated to overall and relative survival. Read More

    Correlation between morphological characteristics in spectral-domain-optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Ophthalmology, Vienna Reading Center, Vienna Clinical Trial Center, Medical University Vienna, Vienna, Austria.
    Purpose: The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical practice.

    Methods: Retinal thickness (RT), the height, area and volume of subretinal fluid (SRF)/pigment epithelium detachments were evaluated using the standardized procedures of the Vienna Reading Center. These morphologic characteristics were compared with functional variables [best-corrected visual acuity (BCVA), contrast sensitivity (CS), retinal sensitivity/microperimetry, fixation stability], and patients' subjective handicap from CSC using the National Eye Institute 25-item Visual Function Questionnaire (NEI VFQ-25). Read More

    Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma-related mental health.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
    The benefits of physical exercise on health and well-being have been studied in a wide range of systemic and ocular diseases, including glaucoma, a progressive optic neuropathy characterized by accelerated apoptosis of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) and insufficient ocular perfusion have been postulated to be the two main theories in glaucoma development and progression. The effects of exercise in these two aspects have been demonstrated by numerous researches. Read More

    Conservative therapy for chalazia: is it really effective?
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
    Purpose: To assess the within-treatment efficacy of hot compresses (HC), HC plus tobramycin (Tobrex) and HC plus tobramycin/dexamethasone (Tobradex) for chalazia treatment.

    Methods: Design: Multicentre, randomized clinical trial (ClinicalTrials.gov identifier, NCT01230593). Read More

    Choroidal thickness and myopia in relation to physical activity - the CHAMPS Eye Study.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Ophthalmology, Odense University Hospital, Odense, Denmark.
    Purpose: To describe the relationship between choroidal thickness (CT) and myopia in relation to physical activity (PA) in a population-based child cohort.

    Methods: In a prospective study of 307 children from the CHAMPS Study Denmark, we used objective data from GT3X accelerometer worn at four periods between 2009 and 2015 to determine the amount and intensity of PA. Intensity was estimated as counts/minutes, and cut-off points were defined at four intensity levels. Read More

    Nestin expression in primary and metastatic uveal melanoma - possible biomarker for high-risk uveal melanoma.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
    Purpose: Nestin, a member of the intermediate filament protein family, has been described as a putative cancer stem cell marker (CSC) in uveal melanoma and poor prognostic factor in a variety of tumours, including cutaneous melanoma. In this study, we examined the expression of nestin in primary (PUM) and metastatic uveal melanoma (MUM) samples, and correlated the findings with histological, clinical and survival data.

    Methods: Nestin expression was assessed by immunohistochemistry in 141 PUM and 26 MUM samples; 11 PUM cases were matched with their corresponding metastases. Read More

    Statin use and vitreoretinal surgery: Findings from a Finnish population-based cohort study.
    Acta Ophthalmol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Public Health, University of Helsinki, Helsinki, Finland.
    Purpose: Vitreoretinal (VR) surgery is the third most common intraocular surgery after refractive and cataract surgery. The impact of statin therapy on VR surgery outcomes remains unclear, despite a potentially beneficial effect. We explored the association of preoperative statin therapy and the need for revitrectomy after primary vitrectomy. Read More

    Axial length growth and the risk of developing myopia in European children.
    Acta Ophthalmol 2017 Dec 19. Epub 2017 Dec 19.
    Department Ophthalmology, Erasmus Medical Centre, Rotterdam, The Netherlands.
    Purpose: To generate percentile curves of axial length (AL) for European children, which can be used to estimate the risk of myopia in adulthood.

    Methods: A total of 12 386 participants from the population-based studies Generation R (Dutch children measured at both 6 and 9 years of age; N = 6934), the Avon Longitudinal Study of Parents and Children (ALSPAC) (British children 15 years of age; N = 2495) and the Rotterdam Study III (RS-III) (Dutch adults 57 years of age; N = 2957) contributed to this study. Axial length (AL) and corneal curvature data were available for all participants; objective cycloplegic refractive error was available only for the Dutch participants. Read More

    Early visual outcomes and optical quality after femtosecond laser small-incision lenticule extraction for myopia and myopic astigmatism correction of over -10 dioptres.
    Acta Ophthalmol 2017 Dec 18. Epub 2017 Dec 18.
    Department of Ophthalmology, Myopia Key Laboratory of the Health Ministry, Eye and ENT Hospital of Fudan University, Shanghai, China.
    Purpose: To investigate early visual and refractive outcomes, corneal stability and optical quality after femtosecond laser small-incision lenticule extraction (SMILE) for treating myopia and myopic astigmatism over -10 D.

    Methods: Thirty eyes (30 patients) with myopia and myopic astigmatism of over -10 D were treated with VisuMaxfemtosecond laser (version 3.0; Carl Zeiss Meditec AG, Jena, Germany). Read More

    Diabetic macular oedema treated with intravitreal anti-vascular endothelial growth factor - 2-4 years follow-up of visual acuity and retinal thickness in 566 patients following Danish national guidelines.
    Acta Ophthalmol 2017 Dec 14. Epub 2017 Dec 14.
    Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
    Purpose: To investigate long-term functional and anatomical outcomes, discontinuation patterns, drug switching and rates of nonimprovement in patients treated with ranibizumab pro re nata (PRN) regimen for diabetic macular oedema (DME) according to the Danish national guidelines.

    Methods: Retrospective cohort study of 566 eyes in 566 patients with centre-involved DME who started intravitreal treatment with ranibizumab between January 2011 and December 2013 in the Greater Copenhagen region. Data were retrieved from a database and patient records between January 2011 and March 2016 and analysed using mixed-model statistics. Read More

    The effect of haemopoietic stem cell transplantation on the ocular phenotype in mucopolysaccharidosis type I (Hurler).
    Acta Ophthalmol 2017 Dec 14. Epub 2017 Dec 14.
    Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.
    Purpose: To determine whether the ocular phenotype in patients with mucopolysaccharidosis type I (MPSI) Hurler is affected by the efficacy of previous haemopoietic stem cell transplantation (HSCT).

    Design: A retrospective cohort study of patients with MPSI who had undergone treatment with HSCT.

    Methods: Ocular phenotype was documented for each patient and compared to levels of biomarkers representing efficacy of previous transplantation. Read More

    Diabetic macular edema, innovative technologies and economic impact: New opportunities for the Lombardy Region healthcare system?
    Acta Ophthalmol 2017 Dec 14. Epub 2017 Dec 14.
    Centre for Health Economics, Social and Health Care Management, Università Carlo Cattaneo - LIUC, Castellanza, Italy.
    Purpose: Diabetic macular edema (DME) is a leading cause of vision loss and blindness. The aim of this study was to evaluate the economic benefits of introducing additional alternative technologies (Dexamethasone intravitreal implant - DEX - and Aflibercept injections), compared with the historical scenario of Ranibizumab intravitreal injections.

    Methods: A 3-year budget impact model was developed, taking into consideration the perspective of the Lombardy Region Healthcare Service (LRHS). Read More

    Corrugated Bruch's membrane in high myopia.
    Acta Ophthalmol 2018 Mar 13;96(2):e147-e151. Epub 2017 Dec 13.
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.
    Purpose: To assess the appearance of Bruch's membrane (BM) in axially elongated eyes.

    Methods: The light-microscopical investigation included histological anterior-posterior sections of human eyes. Using a light microscope, we assessed whether BM in the posterior segment was straight or locally corrugated. Read More

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