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Acta Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Acta Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology and Vision Science, The Eye & ENT Hospital of Fudan University, Shanghai, China.

Purpose: To propose and to evaluate a quantitative measuring method of meibomian gland (MG) vagueness.

Methods: A total of 47 patients (32 female and 15 male, 39.21 ± 11. Read More

Acta Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

Purpose: To employ ultrahigh-resolution (UHR) optical coherence tomography (OCT) for investigation of the early wound healing process in corneal epithelium.

Methods: A custom-built UHR-OCT system assessed epithelial healing in human keratoconic cornea after epi-off crosslinking (CXL) procedure and a wound healing model in rabbits with iatrogenic corneal injury. 3D OCT data sets enhanced obtaining epithelial thickness maps and evaluation of reepithelization stage. Read More

Acta Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Tays Eye Centre, Tampere University Hospital, Tampere, Finland.

Acta Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.

Acta Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Rega Institute for Medical Research, Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.

Purpose: Evidence exists that the interleukin (IL)-10 family of cytokines is involved in autoimmune diseases. The aim of this study was to analyse the levels of the IL-10 family cytokines IL-10, IL-19, IL-20, IL-22, IL-26, IL-28A and IL-29 in aqueous humour (AH) samples from patients with specific uveitic entities. In addition, we correlated their levels with the levels of the proinflammatory cytokines tumour necrosis factor-α (TNF-α) and IL-1β. Read More

Acta Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Clinical Research Department, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Background: Acute optic neuritis (AON) is a common optic nerve disease leading to retrograde degeneration of optic nerve axons, reflected by thinning of the inner retinal layers on optical coherence tomography. On the contrary, acute macular neuroretinopathy (AMN) type 2 is a rare outer retinal disorder that leads to thinning of the outer nuclear layers and is diagnosed by multimodal imaging. The aim of this study was to report a new association between these two diseases. Read More

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Ophthalmology department, Aix-Marseille University, Hôpital Nord, Marseille, France.

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan.

Purpose: To evaluate real-world evidence for young Japanese patients with rhegmatogenous retinal detachment (RRD) by retrospectively examining surgical procedures and clinical outcomes in the Japan Clinical Retina Study group.

Methods: This was a multicentre retrospective study of the medical records of 562 young patients (384 males and 178 females; mean age: 33.0 ± 11. Read More

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.

Purpose: To compare the clinical outcomes of bilateral medial rectus plication and resection for the treatment of convergence insufficiency (CI)-type intermittent exotropia (IXT).

Methods: Fifty-five patients with CI-type IXT were included in this prospective study and were followed for 6 months. The patients were randomized into two groups: the bilateral medial rectus plication (BMRP) group (n = 27) and the bilateral medial rectus resection (BMRR) group (n = 28). Read More

Acta Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Sydney Retina Clinic & Day Surgery, Sydney, NSW, Australia.

Purpose: To report 4-year outcomes following the switch to aflibercept in treatment-resistant neovascular age-related macular degeneration (nAMD).

Methods: In this prospective, open-label, non-controlled, clinical trial, 49 patients with treatment-resistant nAMD received 2 mg intravitreal aflibercept as three loading doses every 4 weeks, followed by injections every 8 weeks for the first 48 weeks, then an individualized regimen for a further 36 months, following previous treatment with ranibizumab and/or bevacizumab. Outcome measures included best-corrected visual acuity (BCVA), central retinal thickness (CRT), pigment epithelial detachment (PED) height and geographic atrophy (GA) surface area. Read More

Acta Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

Department of Clinical Sciences/Ophthalmology, Umeå University Hospital, Umeå, Sweden.

Purpose: To evaluate the efficacy and safety of iris suture fixation of out-of-the-bag dislocated three-piece intraocular lenses (IOL).

Methods: In a retrospective interventional consecutive case series, a chart review was performed in two groups of patients: fourteen patients with a dislocated out-of-the-bag three-piece IOL that underwent IOL fixation to the iris using the Siepser sliding knot technique (Iris group) and 18 patients with in-the-bag dislocation that underwent IOL exchange with a new scleral-sutured IOL (Exchange group). The Iris and Exchange groups were compared regarding surgical safety and efficacy. Read More

Acta Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

Department of Cognitive Neuroscience, Biophysics Section, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands.

Purpose: We determined the latencies of orienting responses during a preferential looking task in children with normal vision and in children with visual impairments between 6 and 12 years old, and assessed the feasibility of scoring grating detection in these populations with video-based eye tracking.

Methods: Children performed a computerized preferential looking test, while a remote eye tracker measured the children's eye movements. The stimuli consisted of a 2 × 2 grid, with three uniform grey fields and one target field consisting of a black-and-white square wave grating. Read More

Acta Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

IgG4-related disease (IgG4-RD) is an immune-mediated systemic fibro inflammatory disease. Treatment of IgG4-related orbital disease (IgG4-ROD) is often indicated to relieve the symptoms and to prevent complications. For IgG4-ROD, no international formal treatment guidelines are available and the optimal treatment strategy is uncertain. Read More

Acta Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.

Background: The scope of the study was the functional assessment of possible effects of intravitreally injected ocriplasmin using electroretinographical (ERG) examinations.

Methods: Seven subjects suffered from pathologies within the label of ocriplasmin (Jetrea ) were examined in the study. An extended international society for clinical electrophysiology of vision ERG protocol was used for baseline recordings (before treatment) and was repeated for comparison 3 months after treatment with intravitreally injected ocriplasmin. Read More

Acta Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Purpose: To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept-source optical coherence tomography angiography (OCTA).

Methods: In this study consecutive patients with intermediate uveitis ± vasculitis and healthy age-matched controls were evaluated using central 3 × 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 × 3 scans and wide field OCTA were evaluated. Read More

Acta Ophthalmol 2019 Feb 3. Epub 2019 Feb 3.

Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.

Purpose: The aim of the present study was to investigate age-specific normative retinal oxygen saturation values and explore the associated factors in healthy Chinese school-aged children with different refractive statuses.

Design: Population-based observational cross-sectional study.

Methods: Children aged 7-19 years were enrolled. Read More

Acta Ophthalmol 2019 Feb 3. Epub 2019 Feb 3.

Department of Ophthalmology, University of Navarra Clinic, Pamplona, Spain.

Purpose: To report 1-year treatment outcomes of P50 EX-PRESS implant versus nonpenetrating deep sclerectomy (NPDS) with Esnoper V2000 combined with phacoemulsification.

Design: Randomized, prospective and multicentre clinical trial.

Methods: Settings: Six clinical centres. Read More

Acta Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Retina Consultants of Houston, Houston, Texas, USA.

Delivery of pharmaceuticals to the posterior segment presents challenges that arise from the anatomy and clearance pharmacokinetics of the eye. Systemic and several local administration options [topical, periocular, intravitreal (IVT) and subretinal] are in clinical use, each with a unique benefit to risk profile shaped by factors including the administered agent, frequency of dosing, achievable pharmaceutical concentrations within posterior segment structures versus elsewhere in the eye or the body, invasiveness of the procedure and the inherent challenges with some administration methods. The use of the suprachoroidal space (SCS), which is the region between the sclera and the choroid, is being explored as a potential approach to target pharmacotherapies to the posterior segment via a minimally invasive injection procedure. Read More

Acta Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyväskylä, Finland.

Purpose: To examine genetic influences on interocular similarities in ocular refraction and components of refraction among elderly female twins.

Methods: Refraction was assessed in 94 monozygotic (MZ) and 74 dizygotic (DZ) female twins aged 66-78 years. Absolute values of interocular differences (Aniso variables) in spherical refraction (SR), refractive astigmatism (AST), spherical equivalent (SE), corneal refractive power (CR), corneal astigmatism (CAST), anterior chamber depth (ACD) and axial length (AL) were calculated. Read More

Acta Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

St. Erik Eye Hospital, Stockholm, Sweden.

Purpose: Albinism degrades visual function due to developmental disorders of the eye and visual pathways, larger refractive errors, absent binocularity and poor fixation control. Reading spectacles is commonly prescribed in our clinic and well tolerated. The purpose was to evaluate whether the accommodative response is typical or affected in comparison to a reference group. Read More

Acta Ophthalmol 2019 Jan 30. Epub 2019 Jan 30.

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: Based on the hypothesis that silicone oil (SO) with a higher refractive index than water induces unexpected vignetting effects during surgeries, we aimed to investigate the relationship between the volume of SO and light intensity using a surgical microscope.

Methods: Using a light-sensitive paper and model eye filled with varying volumes (0%, 50%, 62.5%, 75%, 87. Read More

Acta Ophthalmol 2019 Jan 29. Epub 2019 Jan 29.

Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Purpose: To investigate the effect of astrocyte elevated gene-1 (AEG-1) overexpression on the biological behaviour of human retinoblastoma (RB) cells and its possible mechanism.

Methods: Three human RB cell lines (SO-RB50, Y79 and WERI-RB1) were infected with AEG-1-GFP recombinant lentiviral vectors to induce AEG-1 overexpression, while the cells infected with negative lentiviral vectors and cells without any intervention formed control groups.

Results: All three RB cell lines showed an overexpression of AEG-1 after lentivirus infection (p < 0. Read More

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Retina Research Group, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada.

Purpose: The aim of this study was to assess the relationship between retinal blood oxygen saturation (SO ) and specific aqueous humour (AH) concentrations of proangiogenic biomarkers in diabetic patients with nonproliferative diabetic retinopathy (NPDR) and to compare them with those of matched control subjects.

Methods: The sample comprised 14 participants with mild-to-moderate NPDR (69.1 ± 6. Read More

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

Purpose: To assess novel differences in serum levels of glucose, lactate and amino acids in patients with normal-tension glaucoma (NTG) compared to age-matched controls, at baseline and in response to universal hypoxia.

Methods: Twelve patients diagnosed with NTG and eleven control subjects underwent normobaric hypoxia for 2 hr. Peripheral venous blood samples were taken at baseline, during hypoxia and in the recovery phase. Read More

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Purpose: To examine visual acuity, refraction and ocular status before, during and after hyperbaric oxygen therapy (HBOT).

Methods: Twenty-nine patients underwent 40 standard protocol HBOT treatments. In all subjects, refraction and best corrected visual acuity were measured at baseline and after ten, 20, 30 and 40 treatments, and at a 12-week follow-up. Read More

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.

Purpose: To study the association between chronic hepatitis B virus (HBV) and age-related macular degeneration (AMD).

Methods: Data used in this retrospective, frequency-matched cohort study were acquired from the Longitudinal Health Insurance Database 2000, which includes medical claims and registration files for 1 000 000 enrolees in the Taiwan National Health Insurance programme. The HBV cohort contained 17 796 patients who received a diagnosis of chronic HBV infection between January 1, 2000 and December 31, 2012. Read More

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Randers Regions Hospital, Randers, Denmark.

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Bayer AG, Basel, Switzerland.

Purpose: To determine the influence of baseline myopic macular degeneration (MMD) severity on outcomes with intravitreal aflibercept (IVT-AFL) in patients with myopic choroidal neovascularization (CNV).

Methods: MYRROR was a randomized, double-masked study in patients with myopic CNV treated with IVT-AFL/sham over 48 weeks. At baseline/week 48, images were retrospectively graded for MMD. Read More

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Acta Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Oxford Eye Hospital, John Radcliffe, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Choroideremia is an X-linked recessive retinal degeneration predominantly affecting hemizygous males. It is caused by mutations in the CHM gene that encodes the Rab escort protein-1. Characteristic features include early nyctalopia followed by progressive constriction of peripheral visual fields and sparing of the central vision until late in life with a distinct fundoscopic appearance. Read More

Acta Ophthalmol 2019 Jan 27. Epub 2019 Jan 27.

Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, the Netherlands.

Purpose: Primary vitreoretinal lymphoma [(P)VRL]) is a rare malignancy of the eye localized in the retina, vitreous or choroid. Here, we aim to determine the value of the combination of innovative diagnostic methods for accurate differentiation between (P)VRL and non-(P)VRL in patients with suspect uveitis or vitritis.

Methods: Multicolour flow cytometric immunophenotyping of cells in the vitreous samples was performed using the EuroFlow small sample tube. Read More

Acta Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Tays Eye Centre, Tampere University Hospital, Tampere, Finland.

Acta Ophthalmol 2019 Jan 17. Epub 2019 Jan 17.

Department of Ophthalmology, Chungnam National University Hospital, Deajeon, Korea.

Purpose: To assess influence of the location of visual field (VF) loss on vision-related quality of life (VRQOL) in patients with glaucoma.

Methods: We included 826 patients with primary open-angle glaucoma (POAG) enrolled in the prospectively designed Life Quality of Glaucoma Patients Who Underwent Treatment (LIGHT) study organized by the Korean Glaucoma Society. We divided the integrated binocular visual field (IVF) into four regions and evaluated the associations between Rasch-analysed 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) and location of the IVF using univariate and hierarchical multivariable linear regression. Read More

Acta Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

SPKSO Ophthalmic University Hospital, Medical University of Warsaw, Warsaw, Poland.

Purpose: Kayser-Fleischer ring pathognomonic for Wilson disease (WD) is formed of corneal copper deposits present predominantly within the anterior chamber angle at the Schwalbe's line. The slit-lamp assessment commonly used as a standard of care cannot detect them early enough, as the angle view is obscured by the corneal limbus. The aim of the research was to evaluate the anterior segment optical coherence tomography (AS-OCT), as objective diagnostic assessment of copper deposits forming KF ring in patients with WD. Read More

Acta Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

The Eye Hospital, Rotterdam, The Netherlands.

Flashes and floaters are the hallmark symptoms of a posterior vitreous detachment (PVD) which itself is linked to an increased risk of the development of retinal tears, retinal detachment and vitreous haemorrhage. The aim of this study is to assess the associations of different symptoms-related PVD and the risk of developing retinal tears. A systematic review of articles written in English, using MEDLINE, Embase (via Embase. Read More

Acta Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology, The Chinese People's Liberation Army General Hospital, Beijing, China.

Purpose: To analyse the clinical characteristics of simultaneous bilateral ON patients in China.

Methods: This retrospective study was done on 51 primary bilateral ON patients between April 2008 and July 2016 at the Chinese People's Liberation Army General Hospital. Fifty eight primary unilateral ON patients formed the control group. Read More

Acta Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology, Västmanland County Hospital, Västerås, Sweden.

Acta Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

Key Lab of Myopia, Ministry of Health, Department of Ophthalmology, EYE & ENT Hospital of Fudan University, Shanghai, China.

Purpose: To compare visual outcomes and aberration outcomes in small incision lenticule extraction (SMILE) versus femtosecond laser LASIK (FS-LASIK).

Methods: This prospective, comparative, nonrandomized clinical study included 68 eyes of 37 patients receiving SMILE and 55 eyes of 30 patients receiving FS-LASIK between December 2011 and January 2013 at the Fudan University Eye and ENT Hospital (Shanghai, People's Republic of China). Patients were followed up at 3, 6 months and 5 years after surgery. Read More

Acta Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

University Eye Clinic, Maastricht University Medical Center+, Maastricht, the Netherlands.

Acta Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.

Purpose: To examine preoperative anti-inflammatory treatment on recovery from cataract surgery in eyes of diabetic patients.

Methods: A Prospective randomized clinical trial. One hundred and three eyes of 103 patients with diabetes undergoing routine cataract surgery were randomized (1:1) not to receive any preoperative anti-inflammatory medication or to receive preoperative topical anti-inflammatory medication with a combination of prednisolone acetate (10 mg/ml) and nepafenac (1 mg/ml). Read More

Acta Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.

Acta Ophthalmol 2019 Jan 4. Epub 2019 Jan 4.

Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo, Japan.

Acta Ophthalmol 2018 Dec 31. Epub 2018 Dec 31.

Moorfields Eye Hospital, London, UK.

Purpose: To review the clinical characteristics and address the aetiology in a group of patients presenting with unilateral retinal pigmentary changes, best described as unilateral pigmentary retinopathy (UPR).

Methods: The cohort of 42 patients was identified retrospectively from the Moorfields Eye Hospital electrophysiology database. All had undergone full-field [electroretinography (ERG)] and pattern electroretinography (PERG), with 13 additionally having multifocal ERG (mfERG). Read More

Acta Ophthalmol 2018 Dec 28. Epub 2018 Dec 28.

Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Purpose: To report our experience with photoactivated chromophore corneal cross-linking (PACK-CXL) for treating keratitis patients.

Methods: This retrospective study consists of 27 eyes of 26 patients with infectious keratitis treated with PACK-CXL at the Helsinki University Hospital between 2009 and 2017. Patients were treated with antibiotics/antifungal medications and underwent PACK-CXL procedure due to lack of clinical response or severe corneal melts. Read More

Acta Ophthalmol 2018 Dec 28. Epub 2018 Dec 28.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

Purpose: To study immunogenic properties of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) and to evaluate subretinal xenotransplantation of hESC-RPE on porous polyethylene terephthalate (PET) in rabbits.

Methods: Human ESC-RPE cells were characterized by morphology, transepithelial electrical resistance (TER), protein expression and photoreceptor outer segment phagocytosis in vitro. Expression of major histocompatibility complex (MHC) proteins was assessed in conventionally or xeno-free produced hESC-RPE ± interferon-gamma (IFN-γ) stimulation (n = 1). Read More

Acta Ophthalmol 2018 Dec 28. Epub 2018 Dec 28.

Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet - Glostrup, Glostrup, Denmark.

Purpose: To study Damato Multifixation Campimetry Online (DMCO), an inexpensive online visual field test, used for screening at optician shops in Denmark.

Methods: This was an evaluation of a diagnostic test and customers were included if minimum 50 years old, with a visual acuity of minimum 0.5 and with less myopia than 6 D. Read More

Acta Ophthalmol 2018 Dec 28. Epub 2018 Dec 28.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: The aim of this study was to describe the genetic and clinical characteristics of Chinese patients with autosomal recessive bestrophinopathy (ARB).

Methods: This study presents a retrospective observational case series. Twenty-one ARB patients and 25 clinically healthy family members were recruited. Read More

Acta Ophthalmol 2018 Dec 28. Epub 2018 Dec 28.

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Purpose: To compare the structure and function of the Meibomian gland and eyelid blinking patterns between thyroid eye disease (TED) patients with dry eye and nonthyroidal dry eye (DE) patients.

Methods: This was a prospective, cross-sectional and observational study. Clinical measurements were performed as follows: (1) external examination, (2) Lipiview Interferometer (lipid layer thickness, incomplete blinking rate and meibography) and (3) slit-lamp biomicroscopy (corneal staining, tear break-up time (TBUT), meibum expression). Read More