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    8048 results match your criteria Acta Ophthalmologica[Journal]

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    Efficacy and safety of different regimens for primary open-angle glaucoma or ocular hypertension: a systematic review and network meta-analysis.
    Acta Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
    Purpose: To assess the efficacy and safety of different regimens, including monotherapy and double therapy, for primary open-angle glaucoma (POAG) or ocular hypertension.

    Methods: We searched PubMed, EMBASE and for studies that fit our inclusion criteria in this network meta-analysis. Read More

    Comparison of self-made cryopreservative fibrin glue and commercial fibrin glue kit in pterygium surgery: 1-year follow-up.
    Acta Ophthalmol 2017 Nov 13. Epub 2017 Nov 13.
    Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
    Purpose: To assess long-term efficacy and safety of self-made cryopreservative fibrin glue (SMC) applied in pterygium surgery.

    Methods: Prospective, comparative, interventional case series. Forty eyes of 40 patients with nasal primary pterygium, 24 male and 16 female, were enrolled. Read More

    Randomized controlled trial of electro-stimulation therapies to modulate retinal blood flow and visual function in retinitis pigmentosa.
    Acta Ophthalmol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Biomedical Engineering, Florida International University, Miami, FL, USA.
    Purpose: We examined changes in visual function and ocular and retinal blood flow (RBF) among retinitis pigmentosa (RP) participants in a randomized controlled trial of electro-stimulation therapies.

    Methods: Twenty-one RP participants were randomized (1:1:1) to transcorneal electrical stimulation (TES) at 6 weekly half-hour sessions, electro-acupuncture or inactive laser acupuncture (sham control) at 10 half-hour sessions over 2 weeks. Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity (VA), quick contrast sensitivity function, Goldmann visual fields, AdaptDx scotopic sensitivity, spectral flow and colour Doppler imaging of the central retinal artery (CRA), and RBF in macular capillaries were measured twice pre-treatment, after 2 TES sessions, within a week and a month after intervention completion. Read More

    Age-related macular degeneration: using morphological predictors to modify current treatment protocols.
    Acta Ophthalmol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Ophthalmology and Visual Studies, Yale Medical School, European Vitreo-retinal Society (EVRS), New Haven, Connecticut, USA.
    To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'. We only included studies that had an adequate period of follow-up (>1 year), a single predefined treatment regimen with a predetermined re-injection criteria, an adequate number of patients, specific morphological [optical coherence tomography (OCT)] criteria that predicted final visual outcomes and injection frequency and did not include switching from one drug to the other. Read More

    Efficacy of predetermined therapeutic measures against bleb-related infection in the Collaborative Bleb-related Infection Incidence and Treatment Study.
    Acta Ophthalmol 2017 Nov 8. Epub 2017 Nov 8.
    Department of Ophthalmology, Osaka Koseinenkin Hospital, Osaka, Japan.
    Purpose: To report the efficacy of the predetermined treatment protocol of the Collaborative Bleb-related Infection Incidence and Treatment Study (CBIITS) for bleb-related infection (BRI) patients.

    Methods: A prospective, observational cohort study was conducted at 34 clinical centres in Japan. Nineteen eyes from 19 patients that developed BRI were treated using the CBIITS protocol at 34 clinical centres. Read More

    Iontophoretic collagen cross-linking versus epithelium-off collagen cross-linking for early stage of progressive keratoconus - 3 years follow-up study.
    Acta Ophthalmol 2017 Nov;95(7):e649-e655
    University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania.
    Purpose: To compare 3-year iontophoretic corneal collagen cross-linking (I-CXL) outcomes with epithelium-off corneal collagen cross-linking (epi-off CXL) for early stage of progressive keratoconus.

    Methods: Eighty eyes of 80 patients with early progressive keratoconus treated by I-CXL (n = 40) or epi-off CXL (n = 40) were included in this study. Uncorrected (UDVA) and corrected (CDVA) distance visual acuities, refraction, corneal topography and pachymetry were assessed at baseline and at 1, 3, 6, 12, 24 and 36 months of follow-up. Read More

    Comparison of noncycloplegic and cycloplegic autorefraction in categorizing refractive error data in children.
    Acta Ophthalmol 2017 Nov;95(7):e633-e640
    Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
    Purpose: To systematically analyse the differences between cycloplegic and noncycloplegic refractive errors (RE) in children and to determine if the predictive value of noncycloplegic RE in categorizing RE can be improved.

    Methods: Random cluster sampling was used to select 6825 children aged 4-15 years. Autorefraction was performed under both noncycloplegic and cycloplegic (induced with 1% cyclopentolate drops) conditions. Read More

    Monitoring foveal sparing in geographic atrophy with fluorescence lifetime imaging ophthalmoscopy - a novel approach.
    Acta Ophthalmol 2017 Nov 4. Epub 2017 Nov 4.
    University Hospital Jena, Jena, Germany.
    Purpose: To investigate fundus autofluorescence (FAF) lifetimes in geographic atrophy (GA) with a focus on macular pigment (MP) and foveal sparing.

    Methods: The study included 35 eyes from 28 patients (mean age 79.2 ± 8. Read More

    Genetic prognostication in uveal melanoma.
    Acta Ophthalmol 2017 Nov 4. Epub 2017 Nov 4.
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
    Uveal melanoma (UM) is a rare tumour with a high propensity to metastasize. Although no effective treatment for metastases yet exists, prognostication in UM is relevant for patient counselling, planning of follow-up and stratification in clinical trials. Besides conventional clinicopathologic characteristics, genetic tumour features with prognostic significance have been identified. Read More

    Regulation of oxygen saturation in retinal blood vessels in response to dynamic exercise.
    Acta Ophthalmol 2017 Nov 2. Epub 2017 Nov 2.
    School of Life and Health Sciences, Aston University, Birmingham, UK.
    Purpose: To evaluate the impact of dynamic exercise on retinal vessel oxygen saturation in healthy individuals.

    Methods: Twenty-six healthy participants underwent moderate dynamic exercise (modified Master's two-step exercise). In all subjects, intraocular pressures (IOP), systolic and diastolic blood pressures (SBP and DBP), retinal vessel calibres and retinal arterial and venous oxygen saturation were measured at baseline, immediately following exercise and 15 min postexercise. Read More

    Fundus autofluorescence imaging in hereditary retinal diseases.
    Acta Ophthalmol 2017 Nov 2. Epub 2017 Nov 2.
    Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
    Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to non-invasively map changes at the level of the retinal pigment epithelium (RPE)/photoreceptor complex and alterations of macular pigment distribution. This imaging method is based on the visualization of intrinsic fluorophores and may be easily and rapidly used in routine patient care. Excessive accumulation of lipofuscin granules in the lysosomal compartment of RPE cells represents a common downstream pathogenic pathway in various hereditary and complex retinal diseases. Read More

    Ganglion cell-inner plexiform layer and retinal nerve fibre layer changes within the macula in retinitis pigmentosa: a spectral domain optical coherence tomography study.
    Acta Ophthalmol 2017 Nov 2. Epub 2017 Nov 2.
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
    Purpose: To investigate how macular ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fibre layer (RNFL) thicknesses within the macula change with retinitis pigmentosa (RP) severity.

    Methods: Spectral domain optical coherence tomography (SD-OCT) was used to examine 177 patients with RP and 177 normal controls. An optical coherence tomography (OCT) line scan was used to grade RP severity. Read More

    Association of 150-kDa oxygen-regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy.
    Acta Ophthalmol 2017 Nov 2. Epub 2017 Nov 2.
    Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, KU Leuven, Leuven, Belgium.
    Purpose: 150-kDa oxygen-regulated protein (ORP150), a member of heat-shock protein family located in endoplasmic reticulum (ER), has a critical role in secretion of vascular endothelial growth factor (VEGF). We investigated expression levels of ORP150 and correlated these levels with VEGF and total vitreous antioxidant capacity (TAC) in proliferative diabetic retinopathy (PDR). We also examined expression of ORP150 in retinas of diabetic rats and in human retinal microvascular endothelial cells (HRMEC). Read More

    Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Ophthalmology, Glostrup Hospital, Copenhagen, Denmark.
    Purpose: To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT.

    Methods: This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6-83. Read More

    Macular thinning in prediabetes or type 2 diabetes without diabetic retinopathy: the Maastricht Study.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    University Eye Clinic Maastricht, Maastricht University Medical Center+, Maastricht, The Netherlands.
    Purpose: To assess macular thinning in individuals with prediabetes or type 2 diabetes without diabetic retinopathy (DM2 w/o DR) compared with individuals with normal glucose metabolism (NGM).

    Methods: Using spectral domain optical coherence tomography (SD-OCT), we measured macular thickness in six subfields as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) in 1838 participants from The Maastricht Study, a population-based cohort study (mean age 59 ± 8 years, 49% men, 1087 NGM, 279 prediabetes, 472 DM2 w/o DR). Multivariable linear regression was used to assess the association between macular thickness and glucose metabolism status. Read More

    The RELATION study: efficacy and safety of ranibizumab combined with laser photocoagulation treatment versus laser monotherapy in NPDR and PDR patients with diabetic macular oedema.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Ophthalmology, University of Leipzig, Leipzig, Germany.
    Purpose: To assess efficacy and safety of intravitreal ranibizumab 0.5 mg plus laser (COMBI) versus laser monotherapy (LASER) in patients with visual impairment due to diabetic macular oedema (DME) in either nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) and to analyse the relevance of inner versus outer retinal thickness.

    Methods: In this double-masked, multicentre phase IIIb study, patients (N = 128) were randomized (2:1) to receive COMBI (n = 85) versus LASER (n = 43). Read More

    Computer-aided diagnosis based on enhancement of degraded fundus photographs.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
    Purpose: Retinal imaging is an important and effective tool for detecting retinal diseases. However, degraded images caused by the aberrations of the eye can disguise lesions, so that a diseased eye can be mistakenly diagnosed as normal. In this work, we propose a new image enhancement method to improve the quality of degraded images. Read More

    Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis - a pilot study.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Ophthalmology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
    Purpose: Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS).

    Methods: Thirty-two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing-remitting from of MS (RRMS)]. Read More

    Oxygen venular saturation correlates with a functional loss in primary open-angle glaucoma and normal-tension glaucoma patients.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
    Purpose: To investigate whether there are differences in retinal oxygen saturation in upper and lower visual field hemispheres in primary open-angle glaucoma (POAG) and in normal-tension glaucoma (NTG).

    Methods: This study enrolled POAG and NTG patients exhibiting differences between the upper and lower total deviation (TD) that were either more than 10 or <5 dB. Retinal oxygen saturation measurements in these patients with glaucoma were performed by a non-invasive spectrophotometric retinal oximeter. Read More

    Corneal backward scattering and higher-order aberrations in children with vernal keratoconjunctivitis and normal topography.
    Acta Ophthalmol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
    Purpose: To investigate the corneal backward scattering and higher-order aberrations (HOAs) in children with vernal keratoconjunctivitis (VKC) and normal topography.

    Methods: Thirty-six eyes of 22 patients with VKC and 54 eyes of 34 normal subjects were included. All participants had clear cornea, absence of dry eyes and a normal corneal tomography. Read More

    Postoperative aqueous humour flare as a surrogate marker for proliferative vitreoretinopathy development.
    Acta Ophthalmol 2017 Oct 25. Epub 2017 Oct 25.
    The Rotterdam Eye Hospital/Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands.
    Purpose: As some surgical procedures have been shown to increase postoperative flare values and thus contribute to blood-ocular barrier breakdown, retinal reattachment surgery might influence the risk of developing proliferative vitreoretinopathy (PVR). Therefore, we investigated whether postoperative aqueous flare values are a surrogate marker for the development of postoperative PVR.

    Methods: We prospectively included 195 patients with primary rhegmatogenous retinal detachment (RRD) and measured aqueous laser flare preoperatively, and at 2 and 6 weeks postoperatively. Read More

    Influence of exercise on the structure of the anterior chamber of the eye.
    Acta Ophthalmol 2017 Oct 25. Epub 2017 Oct 25.
    Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Purpose: To measure changes in anterior chamber structure before and after exercise in healthy individuals using anterior segment optical coherence tomography (ASOCT).

    Methods: Thirty-two healthy young individuals performed jogging for 20 min. Eye blinking rate was recorded during rest and exercise. Read More

    Micro-instillation of fluorescein with an inoculation loop for ocular surface staining in dry eye syndrome.
    Acta Ophthalmol 2017 Oct 25. Epub 2017 Oct 25.
    Corneal Graft Biology, Engineering and Imaging Laboratory, EA2521, SFR143, Federative Institute of Research in Sciences and Health Engineering, Faculty of Medicine, Jean Monnet University, Saint-Etienne, France.
    Purpose: To describe and validate the micro-instillation of fluorescein on the ocular surface by a disposable calibrated inoculation loop to improve corneal and conjunctival staining quality.

    Methods: Accuracy and precision of the volume of 0.5% sodium fluorescein collected by a single use 1 μl-calibrated inoculation loop were measured using a precision balance. Read More

    Increased frequency of retinopathy of prematurity over the last decade and significant regional differences.
    Acta Ophthalmol 2017 Oct 25. Epub 2017 Oct 25.
    Section for Ophthalmology, Department of Clinical Neuroscience and rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Purpose: Retinopathy of prematurity (ROP) causes childhood blindness globally in prematurely born infants. Although increased levels of oxygen supply lead to increased survival and reduced frequency of cerebral palsy, increased incidence of ROP is reported.

    Methods: With the help of a Swedish register for ROP, SWEDROP, national and regional incidences of ROP and frequencies of treatment were evaluated from 2008 to 2015 (n = 5734), as well as before and after targets of provided oxygen changed from 85-89% to 91-95% in 2014. Read More

    Cytomegalovirus retinitis in HIV-negative patients - associated conditions, clinical presentation, diagnostic methods and treatment strategy.
    Acta Ophthalmol 2017 Oct 25. Epub 2017 Oct 25.
    Ocular Oncology and Autoimmune Center, The Goldschleger Eye Institute, Sheba Medical Center, Tel Aviv University, Tel Aviv-Yafo, Israel.
    In recent years, numerous reports have tied cytomegalovirus retinitis (CMVR) with multiple systemic conditions in the absence of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). These range from reports in apparently healthy individuals, through conditions rendering limited immune dysfunction such as advanced age and diabetes mellitus, and finally severe immune dysfunction such as in haematological and rheumatological conditions. Reports are also emerging, suggesting that induced local ocular immunosuppression is a risk factor for CMVR. Read More

    A founder mutation in CERKL is a major cause of retinal dystrophy in Finland.
    Acta Ophthalmol 2017 Oct 25. Epub 2017 Oct 25.
    Department of Clinical Genetics, Helsinki University Hospital, Helsinki, Finland.
    Purpose: To study the genetic aetiology of retinal dystrophies (RD) in Finnish patients.

    Methods: A targeted next-generation sequencing (NGS) panel of 105 retinal dystrophy genes was used in a cohort of 55 RD patients.

    Results: The overall diagnostic yield was 60% demonstrating the power of this approach. Read More

    Posterior corneal surface differences between non-laser in situ keratomileusis (LASIK) and 10-year post-LASIK myopic eyes.
    Acta Ophthalmol 2017 Oct 24. Epub 2017 Oct 24.
    School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Purpose: To evaluate the posterior corneal surface differences between non-laser in situ keratomileusis (LASIK) and 10-year post-LASIK myopic eyes.

    Methods: The study included 130 eyes from 65 patients, who were treated with myopic LASIK 10 years ago. In addition, 130 eyes from 65 unoperated myopic patients of matching present age and preoperative refraction were divided into control group. Read More

    Analysis of retinal layer thickness in diabetic macular oedema treated with ranibizumab or triamcinolone.
    Acta Ophthalmol 2017 Oct 24. Epub 2017 Oct 24.
    Department of Ophthalmology and Optometry, Medical University Vienna, Vienna, Austria.
    Purpose: To evaluate detailed changes in retinal layer thickness in spectral-domain optical coherence tomography (SD-OCT) images during a 1-year follow-up of patients treated for diabetic macula oedema (DME).

    Methods: Post hoc analysis of retinal layer thickness changes applying the automated layer segmentation of SD-OCT images in eyes with DME that were randomly assigned to receive pro re nata (PRN) treatment with either 0.5 mg ranibizumab or 8 mg triamcinolone. Read More

    Changes in thickness of central macula and retinal nerve fibre layer in severe hypertensive retinopathy: a 1-year longitudinal study.
    Acta Ophthalmol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.
    Objective: To analyse the longitudinal changes in the thickness of the central macula and retinal nerve fibre layer (RNFL) in patients with hypertensive retinopathy (HTNR) using spectral-domain optical coherence tomography (SD-OCT).

    Methods: This was a prospective cohort study. We studied 18 eyes of patients with HTNR of grade IV who had been followed up for more than 1 year, and 36 normal eyes (without any relevant medical history; the control group). Read More

    Clinical relevance of retinal structure in children with laser-treated retinopathy of prematurity versus controls - using optical coherence tomography.
    Acta Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Genetics Department, Center of Genomic Medicine, University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania.
    Purpose: We aimed to assess the macular anatomy using spectral domain optical coherence tomography (SD-OCT), in children born preterm who had laser-treated retinopathy of prematurity (ROP), and to investigate the relationship between structural changes in macula and visual function.

    Methods: Thirty-seven 3-8 years old children were included in the study in two groups: 20 children born preterm [(<34 weeks of gestation, birthweight (BW) <2000 g)] who had laser-treated ROP in the Neonatology Department, Municipal Clinical Emergency Hospital of Timisoara, Romania; and 17 controls (children born at term, without eye disease, matched for age and gender). Spectral domain optical coherence tomography (SD-OCT) imaging (Spectralis OCT) was performed at central fovea and 1 mm nasally. Read More

    Retinal dysfunction characterizes subtypes of dominant optic atrophy.
    Acta Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Scientific Institute San Raffaele Via Olgettina, Milan, Italy.
    Purpose: To assess preganglionic retinal function using multifocal electroretinogram (mfERG) in patients affected by dominant optic atrophy (DOA) stratified by OPA1 gene mutation.

    Methods: Multifocal electroretinogram (mfERG) was recorded in 18 DOA patients (DOA group, 35 eyes) and 25 age-matched healthy subjects (control group, 25 eyes). Patients were stratified in two groups based on gene mutation: missense mutation (DOA-M group, 11 eyes) and mutation causing haploinsufficiency (DOA-H group, 24 eyes). Read More

    Automated detection of diabetic retinopathy lesions on ultrawidefield pseudocolour images.
    Acta Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.
    Purpose: We examined the sensitivity and specificity of an automated algorithm for detecting referral-warranted diabetic retinopathy (DR) on Optos ultrawidefield (UWF) pseudocolour images.

    Methods: Patients with diabetes were recruited for UWF imaging. A total of 383 subjects (754 eyes) were enrolled. Read More

    Epiretinal membrane surgery: an analysis of 2-step sequential- or combined phacovitrectomy surgery on refraction and macular anatomy in a prospective trial.
    Acta Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Department of Ophthalmology, Rigshospitalet-Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
    Purpose: To assess the impact of combined phacoemulsification-vitrectomy and sequential surgery for idiopathic epiretinal membrane (ERM) on refractive error (RE) and macular morphology.

    Methods: In this prospective clinical trial, we allocated phakic eyes with ERM to (1) cataract surgery and subsequent pars plana vitrectomy (PPV) (CAT group), (2) PPV and subsequent cataract surgery (VIT group) or (3) phaco-vitrectomy (COMBI group). Examinations were at baseline, one month after each surgery, and at 3 months and 12 months of follow-up. Read More

    Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age-related macular degeneration.
    Acta Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Ophthalmology Experimental Laboratory, Universidad de Navarra, Pamplona, Spain.
    Purpose: We sought to determine if specific genetic single nucleotide polymorphisms (SNPs) influence vascular endothelial growth factor inhibition response to ranibizumab in neovascular age-related macular degeneration (AMD).

    Methods: A total of 403 Caucasian patients diagnosed with exudative AMD were included. After a three-injection loading phase, a pro re nata regimen was followed. Read More

    An 8-year follow-up of anti-vascular endothelial growth factor treatment with a treat-and-extend modality for neovascular age-related macular degeneration.
    Acta Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.
    Purpose: To investigate long-term visual results of treatment with anti-vascular endothelial growth factor (VEGF) agents for neovascular age-related macular degeneration (nAMD) following a treat-and-extend regimen.

    Methods: Retrospective review of 155 patients who initiated treatment with bevacizumab for nAMD in one eye. At the final 8-year visit, 40 patients (26%) remained for follow-up. Read More

    Levels of beta-trace protein in optic disc pit with macular detachment.
    Acta Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Faculty of Medicine and Health, Department of Ophthalmology, Örebro University, Örebro, Sweden.
    Background: To report beta-trace protein (βTP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP).

    Methods: Four patients with a serous retinal detachment involving the macula was operated by pars plana vitrectomy (PPV) with C2 F6 gas tamponade and peeling of internal limiting membrane (ILM). Patients with a follow-up period exceeding one year postoperatively were included in the study. Read More

    Outcomes of severe uveitic glaucoma treated with Baerveldt implant: can blindness be prevented?
    Acta Ophthalmol 2017 Sep 18. Epub 2017 Sep 18.
    Maastricht University Medical Centre, University Eye Clinic, Maastricht, The Netherlands.
    Purpose: To evaluate long-term outcomes on efficacy and safety of severe uveitic glaucoma treated with a Baerveldt glaucoma implant (BGI).

    Methods: A retrospective study of 47 eyes of 47 patients with uveitic glaucoma treated by a BGI between September 2002 and September 2015. Main outcome measures were intraocular pressure (IOP), number of glaucoma medications, course of the uveitis, visual acuity (VA) and complications. Read More

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