6,343 results match your criteria Acta Oncologica[Journal]


Moderators and mediators of emotion regulation therapy for psychologically distressed caregivers of cancer patients: secondary analyses from a randomized controlled trial.

Acta Oncol 2021 Jun 10:1-8. Epub 2021 Jun 10.

Department of Psychology and Behavioral Sciences, Aarhus University, Aarhus, Denmark.

Background: Being an informal caregiver (IC) of a cancer patient is often associated with psychological distress. We have recently, in a randomized controlled trial (RCT), demonstrated efficacy of Emotion Regulation Therapy for ICs (ERT-C), evidenced as lower levels of psychological distress. Such efficacy demonstration is important, but a crucial step in improving treatments for the IC population is the identification of moderators (i. Read More

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Toward PET/MRI as one-stop shop for radiotherapy planning in cervical cancer patients.

Acta Oncol 2021 Jun 9:1-9. Epub 2021 Jun 9.

Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Radiotherapy (RT) planning for cervical cancer patients entails the acquisition of both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Further, molecular imaging by Positron Emission Tomography (PET) could contribute to target volume delineation as well as treatment response monitoring. The objective of this study was to investigate the feasibility of a PET/MRI-only RT planning workflow of patients with cervical cancer. Read More

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Functional capacity of prediabetic patients: effect of multimodal prehabilitation in patients undergoing colorectal cancer resection.

Acta Oncol 2021 Jun 8:1-7. Epub 2021 Jun 8.

Department of Anesthesia, McGill University, Montreal, Canada.

Background: Prehabilitation is the process of increasing functional capacity (FC) before surgery. Poor glycemic control is associated with worse outcomes in patients undergoing surgery. Therefore, prediabetic patients could particularly benefit from prehabilitation. Read More

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Dying from cancer with COVID-19: age, sex, socio-economic status, and comorbidities.

Acta Oncol 2021 Jun 8:1-6. Epub 2021 Jun 8.

Department of R & D, Stockholms Sjukhem Foundation, Stockholm, Sweden.

Background: The COVID-19 pandemic has caused excess deaths (all causes) and has disproportionately affected the elderly with certain characteristics.

Objectives: To study how COVID-19 affected cancer deaths regarding age, sex, socio-economic status, comorbidities, and access to palliative care. An additional objective was to study changes in place of care and death. Read More

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Climbing the ladder of success in testicular cancer.

Authors:
Olof Stahl

Acta Oncol 2021 Jun 7:1-2. Epub 2021 Jun 7.

Department of Oncology, Skåne University Hospital, Lund, Sweden.

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High density of cytotoxic T-lymphocytes is linked to tumoral PD-L1 expression regardless of the mismatch repair status in colorectal cancer.

Acta Oncol 2021 Jun 5:1-8. Epub 2021 Jun 5.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Immune checkpoint-inhibitors targeting the PD-1/PD-L1 system are FDA approved in microsatellite instable (MSI) or mismatch repair deficient (dMMR) colorectal cancer (CRC). PD-L1 expression is tightly linked to features connected to immune checkpoint inhibitor response, but studies on large subsets of cancers analyzing the correlation between different status of MSI/dMMR, tumor infiltrating lymphocytes and PD-L1 expression are still lacking.

Methods: More than 1800 CRC were analyzed for PD-L1 by immunohistochemistry in a tissue microarray format. Read More

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Plasma circulating cell free messenger RNA as a potential biomarker of melanoma.

Acta Oncol 2021 Jun 4:1-9. Epub 2021 Jun 4.

Department of Academic Surgery, University College Cork, Cork, Ireland.

Background: Blood borne cell free nucleic acids are increasingly emerging as significant non-invasive adjuncts to current methods of disease status evaluation in cancer patients. In this study, we sought to examine whether significant differences exist in the plasma transcriptomic profile of advanced melanoma patients with a high disease burden compared to patients with a low disease burden or therapeutic response.

Methods: Pathway focussed gene expression analysis was performed using cDNA derived from the plasma circulating cell free messenger ribonucleic acid (ccfmRNA) samples of twenty-two patients with advanced melanoma. Read More

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A randomized phase 2 trial of first-line docetaxel, carboplatin, capecitabine (CTX) and epirubicin, oxaliplatin, capecitabine (EOX) in advanced esophagogastric adenocarcinoma.

Acta Oncol 2021 Jun 4:1-6. Epub 2021 Jun 4.

Department of Oncology, Rigshospitalet, Copenhagen, Denmark.

Background: No preferred first-line chemotherapy regimen exists for advanced esophagogastric adenocarcinoma. Addition of docetaxel to cisplatin and 5-fluorouracil (DCF) has been shown to improve survival but is associated with increased toxicity. In this randomized, non-comparative phase 2 trial, we tested carboplatin, docetaxel, and capecitabine (CTX), a potentially useful modification of DCF (NCT02177552). Read More

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Stage I lung cancer patients with or without symptoms - are the patients different and should we treat them differently?

Acta Oncol 2021 Jun 1:1-6. Epub 2021 Jun 1.

Department of Respiratory Disease, Aarhus University Hospital, Aarhus, Denmark.

Introduction: A large proportion of stage I cancers are found incidentally, which appears to be a prognostic factor. We investigated stage I lung cancers according to whether, or not, there had been clinical suspicion of lung cancer prior to referral and to see, if we could detect any difference regarding patient characteristics, work-up and mortality for incidental vs non-incidental findings as well as for asymptomatic vs symptomatic patients.

Methods: Medical records and referral documents for 177 patients diagnosed with stage I lung cancer were reviewed and divided based on whether the initial CT scan leading to diagnosis had been made due to suspicion of lung cancer or not. Read More

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Impact of delay in diagnosis and treatment-initiation on disease stage and survival in oral cavity cancer: a systematic review.

Acta Oncol 2021 May 27:1-8. Epub 2021 May 27.

Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Aim/objectives: This study aimed to systematically review the literature on the impact of delay in diagnosis and treatment of oral cavity cancer.

Methods: PubMed and Embase were systematically searched for articles reporting impact of delay in diagnosis and treatment on cancer-stage and survival of oral cavity cancer. Studies comprising at least ten patients, and published since the year 2000, were included. Read More

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Prognostic role of pre-treatment magnetic resonance imaging (MRI)-based radiomic analysis in effectively cured head and neck squamous cell carcinoma (HNSCC) patients.

Acta Oncol 2021 May 26:1-9. Epub 2021 May 26.

Head and Neck Cancer Medical Oncology 3 Department, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.

Objectives: To identify and validate baseline magnetic resonance imaging (b-MRI) radiomic features (RFs) as predictors of disease outcomes in effectively cured head and neck squamous cell carcinoma (HNSCC) patients.

Materials And Methods: Training set (TS) and validation set (VS) were retrieved from preexisting datasets (HETeCo and BD2Decide trials, respectively). Only patients with both pre- and post-contrast enhancement T1 and T2-weighted b-MRI and at least 2 years of follow-up (FUP) were selected. Read More

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Surgery for brain metastases - real-world prognostic factors' association with survival.

Acta Oncol 2021 May 25:1-8. Epub 2021 May 25.

Deparment of Oncology, Regional Advisory Unit for Palliative Care, Oslo University Hospital (OUH), Oslo, Norway.

Background: Surgical resection of brain metastases (BM) improves overall survival (OS) in selected patients. Selecting those patients likely to benefit from surgery is challenging. The Graded Prognostic Assessment (GPA) and the diagnosis-specific Graded Prognostic Assessment (ds-GPA) were developed to predict survival in patients with BM, but not specifically to guide patient selection for surgery. Read More

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Overall survival after initial radiotherapy for brain metastases; a population based study of 2140 patients with non-small cell lung cancer.

Acta Oncol 2021 May 25:1-7. Epub 2021 May 25.

Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: Brain metastases (BM) occur in about 30% of all patients with non-small cell lung cancer (NSCLC). BM treatment guidelines recommend more frequent use of stereotactic radiotherapy (SRT). Overall, studies report no difference in overall survival (OS) comparing SRT to whole-brain radiotherapy (WBRT). Read More

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Reduced cancer risk from healthier lifestyle.

Authors:
Brian Køster

Acta Oncol 2021 May 22:1-2. Epub 2021 May 22.

Cancer Prevention & Information, Danish Cancer Society, Copenhagen, Denmark.

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The risk of recurrence in surgically treated head and neck squamous cell carcinomas: a conditional probability approach.

Acta Oncol 2021 May 20:1-6. Epub 2021 May 20.

Department of Medical Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.

Background: Over 50% of patients with head-and-neck squamous cell carcinoma (HNSCC) experience locoregional recurrence, which is associated with poor outcome. In the course of follow-up for patients surviving primary surgery for HNSCC, one might ask: What is the probability of recurrence in one year considering that the cancer has not yet recurred to date?

Materials And Methods: To answer this question, 979 patients surgically treated for HNSCC (i.e. Read More

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Core needle biopsy is an inferior tool for diagnosing cervical lymphoma compared to lymph node excision.

Acta Oncol 2021 May 18:1-7. Epub 2021 May 18.

Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Denmark.

Background: In Denmark, fine needle aspiration is the standardized tool for obtaining tissue samples from lymph nodes (LN) of the neck. However, because of a low specificity toward lymphomas, LNs suspicious for this disease are often surgically removed and examined. International studies have implied that a core needle biopsy (CNB) is sufficient for detecting lymphomas, thereby potentially avoiding surgery. Read More

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AGAPP: efficacy of first-line cisplatin, 5-fluorouracil with afatinib in inoperable gastric and gastroesophageal junction carcinomas. A Hellenic Cooperative Oncology Group study.

Acta Oncol 2021 May 18:1-9. Epub 2021 May 18.

Department of Medical Oncology, University of Ioannina, Ioannina, Greece.

Purpose: Gastric cancer is the fifth most common neoplasm worldwide with high rates of mortality. Afatinib, a low molecular, irreversible potent inhibitor of ErbB trans-membrane receptor family, has shown promising results according to preclinical and phase I clinical trial data when combined with chemotherapy. We aimed at evaluating the safety and efficacy of the combination of cisplatin, 5FU with afatinib in molecularly unselected patients with advanced gastric cancer. Read More

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Impact of parity on the incidence of ovarian cancer subtypes: a population-based case-control study.

Acta Oncol 2021 May 17:1-6. Epub 2021 May 17.

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Parity is known to have a protective effect as regards ovarian cancer, but its effect on the different histological subtypes of ovarian cancer is not well known. The impact of parity on the incidence of ovarian cancer subtypes was studied.

Material And Methods: All Finnish women diagnosed 1994-2013 with ovarian cancer for the first time were included. Read More

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Nordic guidelines 2021 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms.

Acta Oncol 2021 May 17:1-11. Epub 2021 May 17.

Department of Oncology, Haukeland University Hospital, Bergen, Norway.

Background: The diagnostic work-up and treatment of patients with gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) has undergone major advances and new methods are introduced. Furthermore, an update of the WHO classification has resulted in a new nomenclature for GEP-NEN that is implemented in the clinic.

Aim: These Nordic guidelines summarise the Nordic Neuroendocrine Tumour Group's current view on how to diagnose and treat GEP-NEN patients and aims to be useful in the daily practice for clinicians. Read More

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Outcome and safety analysis of endometrial cancer patients treated with postoperative 3D-conformal radiotherapy or intensity modulated radiotherapy.

Acta Oncol 2021 May 17:1-7. Epub 2021 May 17.

Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Background: We sought to analyze the toxicity rates and the treatment outcomes in endometrial cancer (EC) patients treated with postoperative three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT).

Material And Methods: The clinical data of 646 EC patients treated with postoperative adjuvant 3DCRT (265 patients, 41%) or with IMRT (381 patients, 59%) between April 2007 and August 2019 were retrospectively analyzed. The primary endpoints were treatment-related acute and late gastrointestinal (GI) and genitourinary (GU) toxicities. Read More

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Local control after stereotactic body radiotherapy of centrally located lung tumours.

Acta Oncol 2021 May 14:1-5. Epub 2021 May 14.

Department of Medical Physics, Aarhus University Hospital, Aarhus N, Denmark.

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Lifestyle changes and risk of cancer: experience from the Swedish women's lifestyle and health cohort study.

Acta Oncol 2021 May 14:1-8. Epub 2021 May 14.

International Agency for Research on Cancer, Lyon, France.

Background: The impact of lifestyle changes on cancer risk is yet to be elucidated. We investigated this issue in the Swedish Women's Lifestyle and Health Cohort Study.

Material And Methods: We measured changes by comparing two questionnaires, filled in 1991/92 and 2003. Read More

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Cancer diagnosed during the COVID-19 pandemic in the Faroe Islands.

Acta Oncol 2021 May 14:1-3. Epub 2021 May 14.

Centre of Health Science, Tórshavn, Faroe Islands.

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Men receive more end-of-life cancer hospital treatment than women: fact or fiction?

Acta Oncol 2021 May 12:1-8. Epub 2021 May 12.

Department of Health Management and Health Economics, University of Oslo, Norway.

Background: An important goal of health care systems is equitable access to health care. Previous research, however, indicates that men receive more cancer care and health care resources than women. The aim of this study was to investigate whether there is a gender difference in terms of end-of-life cancer treatment in hospitals in Norway. Read More

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Social distancing during the COVID-19 pandemic and health-related quality of life among esophageal cancer survivors.

Acta Oncol 2021 May 11:1-8. Epub 2021 May 11.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Purpose: The purpose was to investigate whether social distancing during the COVID-19 pandemic reduced health-related quality of life (HRQL) in esophageal cancer patients and if so, to identify factors related to the HRQL changes.

Methods: A prospective Swedish nationwide study of patients who undergone surgery for esophageal cancer between 2013 and 2019. Telephone interviews were conducted 5 weeks and 13 weeks after the introduction of social distancing recommendations. Read More

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Treatment outcomes and prognostic factors after chemoradiotherapy for anal cancer.

Acta Oncol 2021 May 8:1-10. Epub 2021 May 8.

Department of Oncology, Oslo University Hospital, Oslo, Norway.

Background: Squamous cell carcinoma of the anus (SCCA) is a rare malignancy with rising incidence, associated with human papilloma virus (HPV). Chemoradiotherapy (CRT) is the preferred treatment. The purpose was to investigate treatment failure, survival and prognostic factors after CRT. Read More

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genetic testing in melanoma-prone families in Sweden in the years 2015-2020: implications for novel national recommendations.

Acta Oncol 2021 May 4:1-9. Epub 2021 May 4.

Department of Oncology and Pathology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

Inherited pathogenic variants (PVs) in the gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancreatic cancer. In this study, the testing, carried out in Sweden in the years 2015-2020, was evaluated. Read More

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