5,837 results match your criteria Acta Oncologica[Journal]


A systematic review of observational studies of trifluridine/tipiracil (TAS-102) for metastatic colorectal cancer.

Acta Oncol 2019 Apr 19:1-9. Epub 2019 Apr 19.

e Department of Oncology , Zealand University Hospital , Roskilde , Denmark.

Background: The treatment options for patients with therapy refractory metastatic colorectal cancer (mCRC) are sparse. TAS-102 (FTD/TPI) is a new oral anti-tumour agent composed of a nucleoside analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil, indicated for patients with mCRC who are refractory to standard therapies. This study summarizes published and unpublished experience with FTD/TPI in clinical practice settings. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1605192DOI Listing

Tumor necrosis correlates with PD-L1 and PD-1 expression in lung adenocarcinoma.

Acta Oncol 2019 Apr 19:1-8. Epub 2019 Apr 19.

b 2nd Department of Pathology, MTA-SE NAP Brain Metastasis Research Group Hungarian Academy of Sciences , Semmelweis University , Budapest , Hungary.

Background: Predictive biomarkers for immunotherapy in lung cancer are intensively investigated; however, correlations between PD-L1/PD-1 expressions and clinical features or histopathological tumor characteristics determined on hematoxylin and eosin stained sections have not extensively been studied.

Material And Methods: We determined PD-L1 expression of tumor cells (TC) and immune cells (IC), and PD-1 expression of IC by immunohistochemistry in 268 lung adenocarcinoma (LADC) patients, and correlated the data with smoking, COPD, tumor grade, necrosis, lepidic growth pattern, vascular invasion, density of stromal IC, and EGFR/KRAS status of the tumors.

Results: There was a positive correlation between PD-L1 expression of TC and IC, as well as PD-L1 and PD-1 expression of IC. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1598575DOI Listing

Automatic stratification of prostate tumour aggressiveness using multiparametric MRI: a horizontal comparison of texture features.

Acta Oncol 2019 Apr 17:1-9. Epub 2019 Apr 17.

a The Sir Peter MacCallum Department of Oncology , The University of Melbourne , Melbourne , Australia.

Background: Previous studies have identified apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) can stratify prostate cancer into high- and low-grade disease (HG and LG, respectively). In this study, we consider the improvement of incorporating texture features (TFs) from T2-weighted (T2w) multiparametric magnetic resonance imaging (mpMRI) relative to mpMRI alone to predict HG and LG disease.

Material And Methods: In vivo mpMRI was acquired from 30 patients prior to radical prostatectomy. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1598576DOI Listing

Increasing use of immunotherapy and prolonged survival among younger patients with primary CNS lymphoma: a population-based study.

Acta Oncol 2019 Apr 17:1-10. Epub 2019 Apr 17.

a Institute of Neurology , Medical University of Vienna , Vienna , Austria.

Background: Primary CNS lymphoma is a highly aggressive and rare type of extranodal non-Hodgkin lymphoma. Although, new therapeutic approaches have led to improved survival, the management of the disease poses a challenge, practice patterns vary across institutions and countries, and remain ill-defined for vulnerable patient subgroups.

Material And Methods: Using information from the Austrian Brain Tumor Registry we followed a population-based cohort of 189 patients newly diagnosed from 2005 to 2010 through various lines of treatment until death or last follow-up (12-31-2016). Read More

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http://dx.doi.org/10.1080/0284186X.2019.1599137DOI Listing

Incidence trends of adult malignant brain tumors in Finland, 1990-2016.

Acta Oncol 2019 Apr 15:1-7. Epub 2019 Apr 15.

b Faculty of Social Sciences , University of Tampere , Tampere , Finland.

Background: Several studies have reported increased incidence trends of malignant gliomas in the late 1900s with a plateau in the 2000s, but also some recent increases have been reported. The purpose of our study was to analyze incidence trends of malignant gliomas in Finland by morphology and tumor location.

Material And Methods: Data on 4730 malignant glioma patients were obtained from case notifications to the nationwide, population-based Finnish Cancer Registry (FCR), and less detailed data on 3590 patients up to 2016. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2019.1
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http://dx.doi.org/10.1080/0284186X.2019.1603396DOI Listing
April 2019
1 Read

Impact of physical exercise on the kynurenine pathway in patients with cancer: current limitations and future perspectives.

Acta Oncol 2019 Apr 11:1-2. Epub 2019 Apr 11.

a Department of Molecular and Cellular Sport Medicine , Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne , Cologne , Germany.

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http://dx.doi.org/10.1080/0284186X.2019.1599139DOI Listing

Patient explicit consideration of tradeoffs in decision making about rectal cancer treatment: benefits for decision process and quality of life.

Acta Oncol 2019 Apr 11:1-8. Epub 2019 Apr 11.

a Department of Biomedical Data Sciences , Leiden University Medical Center , Leiden , The Netherlands.

Introduction: Patient preferences are often not discussed in treatment decisions in oncology. We introduced an online values clarification method (VCM) to help newly diagnosed rectal cancer patients participate in shared decision making about short-course preoperative radiotherapy.

Material And Methods: We offered a link to the VCM to a subset of consecutive patients before the pretreatment consultation with the radiation oncologist. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1594363DOI Listing
April 2019
2 Reads

Language barriers and the use of professional interpreters: a national multisite cross-sectional survey in pediatric oncology care.

Acta Oncol 2019 Apr 8:1-6. Epub 2019 Apr 8.

a Department of Women's and Children's Health, Childhood Cancer Research Unit , Karolinska Institutet , Stockholm , Sweden.

Background: Healthcare personnel are responsible for providing patient-centered care regardless of their patients' language skills, but language barriers is identified as the main hindrances providing effective, equitable and safe care to patients with limited proficiency in a country's majority language. This study is a national multisite cross-sectional survey aiming to investigate communication over language barriers in pediatric oncology care.

Material And Methods: A survey using the Communication over Language Barriers questionnaire (CoLB-q) distributed to medical doctors, registered nurses and nursing assistants at six pediatric oncology centers in Sweden (response rate 90%) using descriptive statistical analyses. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1594362DOI Listing
April 2019
1 Read

Early mortality of stage IV non-small cell lung cancer in the United States.

Acta Oncol 2019 Apr 8:1-7. Epub 2019 Apr 8.

f Department of Radiation Oncology , UC Health - Harmony Campus , Fort Collins , CO , USA.

Background: Early mortality is a major deterrent to oncologic management, often preventing delivery of therapy or leading to administration of treatment that offers limited benefit from aggressive interventions. Due to more recent progress in therapeutic options for stage IV non-small cell lung cancer (NSCLC) patients, identifying those at high risk of early mortality (within 30 days) could have implications for treatment selection. Because early mortality following diagnosis of metastatic non-small cell lung cancer (NSCLC) is not well-characterized, this investigation evaluated national trends and predictors thereof. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1599138DOI Listing

Sex steroid hormone receptor expression in the vaginal wall in cervical cancer survivors after radiotherapy.

Acta Oncol 2019 Apr 8:1-9. Epub 2019 Apr 8.

d Department of Women's and Children's Health , Karolinska Institutet and University Hospital , Stockholm , Sweden.

Background: Sex steroid hormones and their receptors are important in female sexual function. The aim of this study was to investigate the expression and distribution of estrogen receptor (ER)α, ERβ, G-protein-coupled ER-1 (GPER), androgen receptor (AR), progesterone receptor (PR)A, PRB and connective tissue growth factor (CTGF) in the vaginal wall among women who had been treated for cervical cancer with radiotherapy.

Material And Methods: We included cervical cancer survivors treated with radiotherapy and premenopausal control women of the same age scheduled for benign gynecological surgery. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1598574DOI Listing

The association of financial difficulties and out-of-pocket payments with health-related quality of life among breast, prostate and colorectal cancer patients.

Acta Oncol 2019 Apr 4:1-7. Epub 2019 Apr 4.

e Department of Social and Health Management , University of Eastern Finland , Kuopio , Finland.

Objectives: Financial difficulties experienced by cancer patients may affect their health-related quality of life (HRQoL). This study assessed the direct economic burden that out-of-pocket (OOP) payments cause and explored how they and financial difficulties are associated with HRQoL.

Methods: This is a cross-sectional registry and survey study of 1978 cancer patients having either prostate (630), breast (840) or colorectal cancer (508) treated in Finland. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1592218DOI Listing
April 2019
1 Read

Continuous development of colorectal cancer screening programs.

Acta Oncol 2019 Apr 3:1-2. Epub 2019 Apr 3.

a Cancer Registry of Norway , Oslo , Norway.

Colorectal cancer (CRC) screening programs are far from perfect. Many crucial questions remain, yet expensive CRC screening services are implemented throughout the world without a plan on how to evaluate and improve the service. The time is ripe for improving the design of CRC screening programs. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1588475DOI Listing

Association of diagnostic delays to survival in lung cancer: single center experience.

Acta Oncol 2019 Apr 2:1-6. Epub 2019 Apr 2.

a Department of Oncology and Radiotherapy , Oulu University Hospital and MRC Oulu , Oulu , Finland.

Background: Rapid diagnostics and treatment approaches have been applied in many countries to enhance patient satisfaction, but it is unknown whether this leads to improvements in survival.

Material And Methods: Symptoms initiation, referral, and investigations and their timing, and survival were retrospectively collected from all the patients diagnosed for lung cancer at Oulu University Hospital 2015-2016 (n = 221). Correlation of treatment delays to survival was evaluated in different categories and by tumor stages. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1590635DOI Listing
April 2019
1 Read

Potential skin morbidity reduction with intensity-modulated proton therapy for breast cancer with nodal involvement.

Acta Oncol 2019 Apr 2:1-9. Epub 2019 Apr 2.

c Institute of Biostructures and Bioimaging , National Research Council (CNR) , Naples , Italy.

Background: Different modern radiation therapy treatment solutions for breast cancer (BC) and regional nodal irradiation (RNI) have been proposed. In this study, we evaluate the potential reduction in radiation-induced skin morbidity obtained by intensity modulated proton therapy (IMPT) compared with intensity modulated photon therapy (IMXT) for left-side BC and RNI.

Material And Methods: Using CT scans from 10 left-side BC patients, treatment plans were generated using IMXT and IMPT techniques. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1591638DOI Listing
April 2019
4 Reads

Sirolimus monotherapy for Erdheim-Chester disease.

Acta Oncol 2019 Mar 28:1-5. Epub 2019 Mar 28.

d Department of Pathology , Albert Schweitzer Hospital , Dordrecht , The Netherlands.

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http://dx.doi.org/10.1080/0284186X.2019.1589648DOI Listing

Smartphone apps to help children and adolescents with cancer and their families: a scoping review.

Acta Oncol 2019 Mar 27:1-12. Epub 2019 Mar 27.

a Department of Health Information Technology and Management, School of Allied Medical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Introduction: Considering the importance of empowering patients and their families by providing appropriate information and education, it seems smartphone apps provide a good opportunity for this group. The purpose of this review was to identify studies which used smartphone apps to help children and adolescents with cancer and their families.

Method: Arksey and O'Malley's framework was employed in this review. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1588474DOI Listing

Correction.

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Acta Oncol 2019 Mar 27. Epub 2019 Mar 27.

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http://dx.doi.org/10.1080/0284186X.2019.1598134DOI Listing

Treatment and survival of resected and unresected distal cholangiocarcinoma: a nationwide study.

Acta Oncol 2019 Mar 25:1-8. Epub 2019 Mar 25.

a Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , University of Amsterdam , Amsterdam , the Netherlands.

Background: Population-based data on distal cholangiocarcinoma (DCC) from the Western world are not available, albeit essential to identify areas for improvement. This study investigated the incidence, treatment and outcomes, including time trends and predictors for survival, in a nationwide cohort of DCC.

Methods: This is a retrospective cohort study of patients diagnosed with DCC (2009-2016) derived from the Netherlands Cancer Registry. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1590634DOI Listing
March 2019
8 Reads

Obesity and chemotherapy administration: between empiric and mathematic method review.

Acta Oncol 2019 Mar 23:1-8. Epub 2019 Mar 23.

a Département d'oncologie médicale , Institut de cancérologie Lucien Newirth , Saint Priest en Jarez , France.

Introduction: Obesity is a major risk factor for chronic disease and cancer development. Therapeutic management of obese patients with cancer is a real challenge for physician because of the alteration of antineoplastic pharmacokinetics parameters in this population. In routine clinical practices, chemotherapy doses in obese patients are arbitrarily capped or adjusted to an ideal weight to minimize excessive toxicities. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1585942DOI Listing
March 2019
2 Reads

The CDK 4/6 inhibitor ribociclib has activity in the treatment of inoperable desmoid tumor. A case report.

Acta Oncol 2019 Mar 25:1-4. Epub 2019 Mar 25.

a Department of Oncology, Comprehensive Cancer Center , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

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http://dx.doi.org/10.1080/0284186X.2019.1588992DOI Listing

The effect of postoperative gemcitabine on overall survival in patients with resected pancreatic cancer: A nationwide population-based Danish register study.

Acta Oncol 2019 Mar 25:1-8. Epub 2019 Mar 25.

m Danish Pancreatic Cancer Database , Denmark.

Background: Adjuvant chemotherapy following curative resection is the standard treatment for pancreatic adenocarcinoma (PC). Randomized clinical trials using gemcitabine have shown a median overall survival (mOS) of 2 years and a 5-year survival rate of 15-20%. However, the effect of gemcitabine outside these trials is less clear. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581374DOI Listing

Socioeconomic position, referral and attendance to rehabilitation after a cancer diagnosis: A population-based study in Copenhagen, Denmark 2010-2015.

Acta Oncol 2019 Mar 25:1-7. Epub 2019 Mar 25.

a Survivorship, Danish Cancer Society Research Center , Copenhagen , Denmark.

Background: Implementation of new cancer services may lead to socioeconomic differences in uptake and despite reports of more unmet needs among patients with low socioeconomic position studies have found that these patients receive less rehabilitation. We aimed to investigate associations between indicators for socioeconomic position and referral as well as attendance to rehabilitation for cancer.

Methods: Through the Danish Cancer Registry, we identified all persons diagnosed with cancer in Copenhagen municipality 2010-2015 and obtained information on referral to and visits at the municipal rehabilitation center from municipal records. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1582800DOI Listing
March 2019
1 Read

Reduced inter-observer and intra-observer delineation variation in esophageal cancer radiotherapy by use of fiducial markers.

Acta Oncol 2019 Mar 25:1-8. Epub 2019 Mar 25.

a Department of Radiation Oncology , Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam , Amsterdam , The Netherlands.

Objective: Delineation variation of esophageal tumors remains a large source of geometric uncertainty. In the present study, we investigated the inter- and intra-observer variation in esophageal gross tumor volume (GTV) delineation and the impact of endoscopically implanted fiducial markers on these variations.

Material/methods: Ten esophageal cancer patients with at least two markers endoscopically implanted at the cranial and caudal tumor borders and visible on the planning computed tomography (pCT) were included in this study. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1588991DOI Listing

Satisfaction with information on nilotinib treatment in chronic myeloid leukemia patients.

Acta Oncol 2019 Mar 25:1-6. Epub 2019 Mar 25.

a Department of Clinical Pharmacology and Pharmacy , Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam , Amsterdam , Netherlands.

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http://dx.doi.org/10.1080/0284186X.2019.1585944DOI Listing

Second cancers in radically treated Norwegian prostate cancer patients.

Acta Oncol 2019 Mar 25:1-7. Epub 2019 Mar 25.

a Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences , NTNU, Norwegian University of Science and Technology , Trondheim , Norway.

Introduction: The aim of this registry-based cohort study was to estimate second cancer (SC) risk following radical prostate cancer (PC) treatment and evaluate if the risk was influenced by radiotherapy.

Materials And Methods: We collected data from the Cancer Registry of Norway on all patients with PC as first cancer diagnosis, from 1997 to 2014. Standardized incidence ratios (SIRs) for SC were calculated by comparing our cohort to the standard male population. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581377DOI Listing
March 2019
1 Read

Reproducibility and accuracy of visual estimation of polyp size in large colorectal polyps.

Acta Oncol 2019 21;58(sup1):S37-S41. Epub 2019 Mar 21.

a Department of Surgery , Odense University Hospital , Svendborg , Denmark.

Background: Previous studies indicate that visual size estimation (in situ) of polyp size tends to differ from postfixation measurements, which effects allocation to surveillance intervals. Little is known about interobserver variation of in-situ measurements of large polyps. The primary objective was to assess interobserver variation of in situ measurements of large colorectal polyps. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1588990DOI Listing
March 2019
1 Read

Incidence and inheritance of hyperphosphorylated paratarg-7 in patients with Waldenstrom's macroglobulinaemia in Sweden.

Acta Oncol 2019 Mar 19:1-4. Epub 2019 Mar 19.

c Department of Hematology , Karolinska Institute , Stockholm , Sweden.

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http://dx.doi.org/10.1080/0284186X.2019.1582798DOI Listing
March 2019
2.997 Impact Factor

Correction.

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Acta Oncol 2019 03 18;58(3):393. Epub 2019 Mar 18.

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http://dx.doi.org/10.1080/0284186X.2019.1587254DOI Listing

Early and late side effects, dosimetric parameters and quality of life after proton beam therapy and IMRT for prostate cancer: a matched-pair analysis.

Acta Oncol 2019 Mar 18:1-10. Epub 2019 Mar 18.

a OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.

Purpose: To compare early and late toxicities, dosimetric parameters and quality of life (QoL) between conventionally fractionated proton beam therapy (PBT) and intensity-modulated radiation therapy (IMRT) in prostate cancer (PCA) patients.

Methods: Eighty-eight patients with localized PCA treated between 2013 and 2017 with either definitive PBT (31) or IMRT (57) were matched using propensity score matching on PCA risk group, transurethral resection of the prostate, prostate volume, diabetes mellitus and administration of anticoagulants resulting in 29 matched pairs. Early and late genitourinary (GU) and gastrointestinal (GI) toxicities according to Common Terminology Criteria for Adverse Events (CTCAE) and QoL based on EORTC-QLQ-C30/PR25 questionnaires were collected prospectively until 12 months after radiotherapy (RT). Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581373DOI Listing
March 2019
1 Read

Use of phthalate-containing prescription drugs and the risk of gastric cancer: a Danish nationwide case-control study.

Acta Oncol 2019 Mar 18:1-7. Epub 2019 Mar 18.

a Department of Clinical Biochemistry and Pharmacology , Odense University Hospital , Odense , Denmark.

Background: Phthalates are used as excipients in some drug products, and up to a 50-fold increased urinary excretion of phthalate metabolites compared to non-users has been demonstrated in users of such products. In vitro studies have demonstrated that phthalates stimulate mechanisms involved in gastric cancer development. We therefore examined the association between cumulative phthalate exposure from drug products and the risk of gastric adenocarcinomas. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1585941DOI Listing

Lessons learned from the maturation of a cancer drug: oxaliplatin in colorectal cancer.

Acta Oncol 2019 Apr 18;58(4):395-397. Epub 2019 Mar 18.

a Department of Immunology, Genetics and Pathology , Uppsala University , Uppsala , Sweden.

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http://dx.doi.org/10.1080/0284186X.2019.1584405DOI Listing

Changes in fatigue, health-related quality of life and physical activity after a one-week educational program for cancer survivors.

Acta Oncol 2019 Mar 12:1-8. Epub 2019 Mar 12.

a National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology , Division of Cancer Medicine, Oslo University Hospital , Oslo , Norway.

Background: Rehabilitation aims to improve function, but the effects of different programs are not clear. The aims of the present study were to: (1) compare the level of fatigue and health-related quality of life (HRQOL) of cancer survivors admitted to a one-week inpatient educational program (IEP) to the general population (NORMS), (2) examine changes in fatigue, HRQOL and physical activity after the IEP and (3) examine the proportions of survivors for female and male separately with clinically relevant improvement (>10% of maximum scale).

Methods: Cancer survivors ≥18 years, diagnosed with breast-, prostate- or gastrointestinal cancer within the last 10 years, about to attend a one-week IEP were invited to an observational study with a pre-post design. Read More

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http://dx.doi.org/10.1080/0284186X.2018.1562210DOI Listing
March 2019
1 Read

Sociodemographic disparities in stage-specific incidences of endometrial cancer: a registry-based study in West Sweden, 1995-2016.

Acta Oncol 2019 Mar 8:1-7. Epub 2019 Mar 8.

e Research and Development, Region Halland , Halmstad , Sweden.

Background: For a few types of cancer, lower socioeconomic status (SES) is associated with higher incidence, and for even more cancer types it is associated with having a less favorable tumor stage at diagnosis. For endometrial cancer (EC), however, there is no clear evidence of such associations with SES. There is a need for analysis of sociodemographic disparities in EC incidences according to stage at diagnosis, which may provide support for trying to improve early detection of EC. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581947DOI Listing
March 2019
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Differences in baseline characteristics and 1-year psychological factors between participants and non-participants in the randomized, controlled trial regarding patient-led follow-up after rectal cancer (FURCA).

Acta Oncol 2019 Mar 5:1-7. Epub 2019 Mar 5.

a Department of Surgery , Aarhus University Hospital , Aarhus , Denmark.

Background: The ongoing multi-center randomized FURCA-trial investigates the effect of patient-led follow-up after rectal cancer, aiming at improving management of late effects and survivorship care. The purpose of this present sub-study was to identify potential systematic differences between participants and non-participants in the FURCA-trial, in regard to demographic and clinical factors at baseline, and in quality of life (QoL) and fear of cancer recurrence (FCR) after one year.

Material And Methods: The population comprised patients invited to the FURCA-trial during the first 13 months' recruitment. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581948DOI Listing

Addressing priority challenges in the detection and assessment of colorectal polyps from capsule endoscopy and colonoscopy in colorectal cancer screening using machine learning.

Acta Oncol 2019 5;58(sup1):S29-S36. Epub 2019 Mar 5.

a The Maersk Mc-Kinney Møller Institute, University of Southern Denmark , Odense , Denmark.

Background: Colorectal capsule endoscopy (CCE) is a potentially valuable patient-friendly technique for colorectal cancer screening in large populations. Before it can be widely applied, significant research priorities need to be addressed. We present two innovative data science algorithms which can considerably improve acquisition and analysis of relevant data on colorectal polyps obtained from capsule endoscopy. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1584404DOI Listing

Association of pazopanib-induced toxicities with outcome of patients with advanced soft tissue sarcoma; a retrospective analysis based on the European Organisation for Research and Treatment of Cancer (EORTC) 62043 and 62072 clinical trials.

Acta Oncol 2019 Mar 4:1-8. Epub 2019 Mar 4.

g Department of Medical Oncology , Leiden University Medical Center , Leiden , the Netherlands.

Background: There is an unmet need for markers predicting the outcome of patients with advanced soft tissue sarcoma (STS) treated with pazopanib. Since toxicity might be related to the anti-tumor activity of the drug, the aim of this study was to determine whether pazopanib-induced proteinuria, hypothyroidism and cardiotoxicity grade 3-4 were associated with outcome.

Methods: The combined results of the EORTC 62043 and 62072 trials were retrospectively assessed and used in a landmark analysis to evaluate the effect of the toxicities on progression-free survival (PFS) and overall survival (OS), using the Kaplan-Meier method and Cox regression models. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581376DOI Listing
March 2019
2 Reads

Genetic risk factors for cancer-related cognitive impairment: a systematic review.

Acta Oncol 2019 Mar 1:1-11. Epub 2019 Mar 1.

a Unit for Psychooncology and Health Psychology, Department of Oncology, Aarhus University Hospital, and Department of Psychology and Behavioural Sciences , Aarhus University , Aarhus , Denmark.

Background: Cancer-related cognitive impairment (CRCI) is a commonly reported complaint among non-CNS cancer patients. Even subtle CRCI may have detrimental effects on quality of life and identifying patients at increased risk for CRCI to improve survivorship care is important. In the present paper, we systematically reviewed available studies of possible genetic risk factors for developing CRCI. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1578410DOI Listing

Screening individuals' experiences of colonoscopy and colon capsule endoscopy; a mixed methods study.

Acta Oncol 2019 1;58(sup1):S71-S76. Epub 2019 Mar 1.

b Faculty of Health Sciences, Clinical Institute , University of Southern Denmark , Odense , Denmark.

Background: The standard investigation in colorectal cancer screening (optical colonoscopy [OC]) has a less invasive alternative with the colon capsule endoscopy (CCE). The experiences of screening individuals are needed to support a decision aid (DA) and to provide a patient view in future health technology assessments (HTA). We aimed to explore the experiences of CCE at home and OC in an outpatient clinic by screening participants who experienced both investigations on the same bowel preparation. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581372DOI Listing
March 2019
3 Reads

Women with cervical cancer precursor lesions: a high-risk group for human papillomavirus (HPV)-related oropharyngeal cancer?

Acta Oncol 2019 Mar 1;58(3):265-266. Epub 2019 Mar 1.

a Unit of Virus, Lifestyle and Genes , Danish Cancer Society Research Center , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/0284186X.2019.1581378DOI Listing

Cancer incidence and mortality after heart transplantation - A population-based national cohort study.

Acta Oncol 2019 Mar 1:1-5. Epub 2019 Mar 1.

a Heart and Lung Center , Helsinki University Hospital , Helsinki , Finland.

Background: Cancer is currently one of the most important factors affecting the long-term health and survival of heart transplant patients.

Material And Methods: We calculated the standardized incidence ratios (SIR) for different cancer sites and the cancer-specific standardized mortality ratio (SMR) by linking a cohort of 479 adult heart transplant recipients transplanted in 1985-2014 (4491.6 person-years of follow-up) with data from the national Finnish Cancer Registry until the end of 2015, and with the data from the Statistics Finland's national registry of causes of death. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1580385DOI Listing
March 2019
2 Reads

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014.

Acta Oncol 2019 Mar 1:1-6. Epub 2019 Mar 1.

a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

Background: The purpose of this registry study was to evaluate trends in incidence and survival of laryngeal cancer in the Danish population from 1980 to 2014.

Methods: This study includes all patients with laryngeal cancer registered in the Danish Cancer Registry (DCR) in the period 1980-2014. The age-adjusted incidence rate (AAIR) per 100,000 and average annual percent change (AAPC) were calculated. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2019.1
Publisher Site
http://dx.doi.org/10.1080/0284186X.2019.1572923DOI Listing
March 2019
4 Reads

Long-term outcomes following stereotactic body radiotherapy boost for oropharyngeal squamous cell carcinoma.

Acta Oncol 2019 Feb 27:1-8. Epub 2019 Feb 27.

a Department of Radiation Oncology , Erasmus MC Cancer Institute , Rotterdam , The Netherlands.

Background/purpose: To determine the efficacy and toxicity profile of a stereotactic body radiotherapy (SBRT) boost as a first line treatment in patients with oropharyngeal squamous cell carcinoma (OPSCC).

Materials And Methods: We performed a retrospective cohort study in 195 consecutive OPSCC patients with T1-small T3 disease, treated at Erasmus MC between 2009 and 2016 with a SBRT (3 × 5.5 Gy) boost after 46 Gy IMRT. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1581375DOI Listing
February 2019
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Pharmacokinetic analysis of DCE-MRI data of locally advanced cervical carcinoma with the Brix model.

Acta Oncol 2019 Feb 27:1-10. Epub 2019 Feb 27.

a Department of Radiation Biology , Institute for Cancer Research, Oslo University Hospital , Oslo , Norway.

Background: There is significant evidence that DCE-MRI may have the potential to provide clinically useful biomarkers of the outcome of locally advanced cervical carcinoma. However, there is no consensus on how to analyze DCE-MRI data to arrive at the most powerful biomarkers. The purpose of this study was to analyze DCE-MRI data of cervical cancer patients by using the Brix pharmacokinetic model and to compare the biomarkers derived from the Brix analysis with biomarkers determined by non-model-based analysis [i. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1580386DOI Listing
February 2019

Geometrical tracking accuracy and appropriate PTV margins for robotic radiosurgery of liver lesions by SBRT.

Acta Oncol 2019 Feb 23:1-10. Epub 2019 Feb 23.

a Department of Physics , Carleton University , Ottawa , Canada.

Purpose: To assess the geometrical accuracy and estimate adequate PTV margins for liver treatments using the Synchrony respiratory tracking system.

Material And Methods: Treatment log files are analyzed for 72 liver patients to assess tracking accuracy. The tracking error is calculated as the quadratic sum of the correlation, the predictor and the beam positioning errors. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1578896DOI Listing
February 2019

Observational study of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer.

Acta Oncol 2019 Mar 23;58(3):385-387. Epub 2019 Feb 23.

h Department of Oncology , Odense University Hospital, Institute of Clinical Research, University of Southern Denmark , Odense , Denmark.

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http://dx.doi.org/10.1080/0284186X.2019.1566771DOI Listing

Adjuvant radiotherapy after local excision of rectal cancer.

Acta Oncol 2019 21;58(sup1):S60-S64. Epub 2019 Feb 21.

a Department of Colorectal Surgery , Oxford University Hospitals , Oxford , UK.

Background: Local excision is now accepted as a standard treatment option for certain patients with early rectal cancer. However, there is a higher risk of local recurrence than after radical surgery with total mesorectal excision. Adjuvant radiotherapy after local excision may reduce this excess risk, and yet retain the benefits of local excision, with rectal preservation. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1578895DOI Listing
February 2019

Patient-reported minor adverse events after colonoscopy: a systematic review.

Acta Oncol 2019 20;58(sup1):S22-S28. Epub 2019 Feb 20.

a The Department of Surgery , Odense University Hospital , Denmark.

Objective: The purpose of this systematic review was to investigate the incidence and nature of minor adverse events (MAEs) after colonoscopy, and response rates to questionnaires concerning MAEs in patients undergoing colonoscopy.

Materials And Methods: A systematic literature search was conducted in the databases PubMed and Embase. Predictor variables were patient-reported MAEs after colonoscopy. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1574979DOI Listing
February 2019

Proton therapy for thymic malignancies: multi-institutional patterns-of-care and early clinical outcomes from the proton collaborative group and the university of Florida prospective registries.

Acta Oncol 2019 Feb 20:1-5. Epub 2019 Feb 20.

a University of Florida Health Proton Therapy Institute , Jacksonville , FL , USA.

Objective: Thymic malignancies (TM) are rare tumors with long-term survivorship, causing concerns for radiotherapy-related late side effects. Proton therapy (PT) reduces the radiation dose to organs at risk, potentially decreasing long-term toxicities while preserving disease control. We report patterns-of-care and early clinical outcomes after PT for thymoma and thymic carcinoma. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1575981DOI Listing
February 2019
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