Acta Odontol Scand 2022 Jun 12:1-10. Epub 2022 Jun 12.
Department of Periodontology, State University of Western Paraná - UNIOESTE, Cascavel, Brazil.
Objective: This study aimed to evaluate whether ligature-induced periodontitis and rheumatoid arthritis (RA) potentiate the deleterious effects on functional capacity, periodontal and synovial tissues, leukocyte migration, and interleukin 17 (IL-17) levels, and to investigate the repercussions of single Freund's Complete Adjuvant (FCA) injection associated with periodontitis.
Materials And Methods: Fifty-one male rats were randomised into six groups: control (CG, = 8), RA (RAG, = 9), periodontitis (PG, = 9), periodontitis and RA (PRAG, = 9), periodontitis and intradermal injection (PIDG, = 9), and periodontitis and intra-articular injection (PIAG, = 7). The animals underwent ligature placement and one or two injections with FCA to induce RA. Read More