Search Our Scientific Publications & Authors

Acta Obstet Gynecol Scand 2020 Jul 8. Epub 2020 Jul 8.

Department of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway.

Introduction: Medical quality registries have gained popularity as tools for monitoring the quality of medical treatments and serve as data source for research. The Norwegian Female Incontinence Registry (NFIR) was established in 1998 to monitor and improve the quality of surgery for women with stress and mixed urinary incontinence in Norway and to collect data for research. The present study aimed to assess the completeness and accuracy of the Norwegian Female Incontinence Registry, and potential differences in data accuracy over time and according to surgical volume of the reporting hospitals. Read More

Acta Cytol 2020 Jul 8:1-3. Epub 2020 Jul 8.

Department of Pathology and Laboratory Medicine, UCLA, David Geffen School of Medicine, Los Angeles, California, USA,

Biochim Biophys Acta Proteins Proteom 2020 Jul 5:140482. Epub 2020 Jul 5.

Department of Chemistry and the Beckman Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, United States. Electronic address:

d-Alanine (d-Ala) is an unusual endogenous amino acid present in invertebrates and vertebrates. Compared to its l-isomer, the characterization of d-Ala is challenging because of the need for chiral resolution and the low amounts of the d-enantiomer present. With recent improvements in measurement capabilities, research on d-Ala, along with other d-amino acids, has been growing, especially as the functional significance of d-Ala in the mammalian nervous and endocrine systems is becoming known. Read More

Acta Physiol (Oxf) 2020 Jul 8:e13535. Epub 2020 Jul 8.

Discipline of Physiology and the Bosch Institute, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW, 2006, Australia.

This review examines kinetic properties and distribution of the eleven isoforms of myosin heavy chain (MyHC) expressed in extraocular muscle (EOM) fibre types and the regulation and function of these MyHCs. Although recruitment and discharge characteristics of ocular motoneurons during fixation and eye movements are well documented, work directly linking these properties with motor unit contractile speed and MyHC composition is lacking. Recruitment of motor units according to Henneman's size principle has some support in EOMs but needs consolidation. Read More

Acta Paediatr 2020 Jul 8. Epub 2020 Jul 8.

Research Unit in Congenital and Perinatal Infections, Academic Department of Pediatrics (DPUO), Division of Immunology and Infectious Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Coronavirus disease (COVID-19) caused by the novel SARS-CoV-2 has spread worldwide since its onset in Wuhan in December 2019. In Italy COVID-19 rapidly increased in February 2020 and by 12 May 2020, 2.0 % of the confirmed cases were under 18 years and 3. Read More

Acta Paediatr 2020 Jul 8. Epub 2020 Jul 8.

Arabkir" Medical Center, Department of Pediatric Surgery, Yerevan State Medical University, Armenia.

Aim: Necrotizing enterocolitis (NEC) is still a disease with high morbidity and mortality. The aim of the study was to analyse retrospectively whether the introduction of a multi-modal three-component enteral medication regimen resulted in a change in morbidity and mortality in neonates NEC.

Methods: When diagnosis of NEC was established, the following multi-modal three-component enteral medication regimen was administered enterally (via nasogastric tube): an antibiotic, an antifungal agent, and a probiotic. Read More

Acta Paediatr 2020 Jul 8. Epub 2020 Jul 8.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Aim: We investigated the impact of varying definitions on the prevalence of neurodevelopmental impairment (NDI) in children born very preterm at 6.5 years of age.

Methods: Cognitive development and neurosensory impairments were assessed in 91 children (40/51 girls/boys) born <32 gestational weeks, in 2004-2007 in Uppsala county, Sweden. Read More

Acta Obstet Gynecol Scand 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatric Cardiology, Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Introduction: Newborns with transposition of the great arteries (d-TGA) need immediate care for an optimal outcome. This study comprised a nationwide 11-year population-based cohort of d-TGA infants, and assessed whether the implementation of a nationwide systematic fetal screening program, or other perinatal - or perioperative factors, are associated with mortality or an increased need for hospital care.

Material And Methods: The national cohort consisted of all live-born infants with simple d-TGA (TGA +/- small ventricular septal defect, n = 127) born in Finland during 2004-2014. Read More

Acta Cir Bras 2020 Jul 6;35(5):e202000508. Epub 2020 Jul 6.

MD, Department of General Surgery, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China. Acquisition, analysis and interpretation of data; technical procedures; critical revision; manuscript preparation, final approval.

Purpose: To analyze the plasma lipid spectrum between healthy control and patients with pancreatic cancer and to select differentially expressed tumor markers for early diagnosis.

Methods: In total, 20 patents were divided into case group and healthy control group according to surgical pathology. Of almost 1206 plasma lipid molecules harvested from 20 patients were measured by HILIC using the normal phase LC/MS. Read More

Acta Cir Bras 2020 Jul 3;35(5):e202000507. Epub 2020 Jul 3.

PhD, Associate Professor, Department of Pharmaceutical Science, UEPG, Ponta Grossa-PR, Brazil. Design of the study, technical procedures, interpretation of data, manuscript writing, critical revision, final approval.

Purpose: To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions.

Methods: The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Read More

Acta Cir Bras 2020 Jul 3;35(5):e202000506. Epub 2020 Jul 3.

PhD, Full Professor, Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China. Design and supervised all phases of the study, critical revision, final approval.

Purpose: To examine effects of resveratrol on renal ischemia/ reperfusion injury (I/R) in a streptozotocin (STZ)-induced diabetic rat model.

Methods: Twenty-four male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: Sham group, I/R group and Resveratrol group (n=8). Resveratrol (RSV) was administered at a dose of 10 mg. Read More

Acta Cir Bras 2020 Jul 6;35(5):e202000504. Epub 2020 Jul 6.

MD, Department of General Surgery, University of Health Sciences Adana City Training and Research Hospital, Adana, Turkey. Acquisition of data.

Purpose: 5-flourourasil (5-FU) is commonly used for early intraperitoneal chemotherapy in colorectal or appendiceal cancer patients with peritoneal carcinomatosis. Due to its effect, anastomosis healing can be impaired and leads to anastomotic leakage. In this study, we aimed to investigate the potential healing effect of platelet-rich plasma (PRP) on colonic anastomosis impaired by intraperitoneal 5-flourouracil application. Read More

Acta Cir Bras 2020 Jul 6;35(5):e202000502. Epub 2020 Jul 6.

Full Professor, Department of Oncology, Shanxi Province Research Institute of Traditional Chinese Medicine, Taiyuan, China. Conception and design of the study, provision of reagents, materials and analysis tools.

Purpose: Changrui enema, a traditional Chinese medicine prescription, is used as a supplementary treatment for acute radiation proctitis (ARP). Herein we explored the inhibition effects of Changrui enema on NF-κB and VEGF in ARP mice.

Methods: A total of 120 C57BL/6 mice were divided randomly into normal mice group, ARP mice group, western medicine enema group (dexamethasone combined with gentamicin), and Changrui enema group. Read More

Acta Cir Bras 2020 Jul 3;35(5):e202000501. Epub 2020 Jul 3.

PhD, Full Professor, Department of Veterinary Surgery, FCAV, UNESP, Jaboticabal-SP, Brazil. Conception, intellectual and scientific content of the study; critical revision.

Purpose: To assess the feasibility of thoracoscopic transdiaphragmatic approach for biopsy of all lung lobes and to determine the optimal intercostal space (ICS) for biopsy of each lung lobe.

Methods: Ten rabbits were positioned in dorsal recumbency. Total thoracoscopy lung biopsy was made combined transdiaphragmatic approach and right ICS approaches. Read More

Acta Cir Bras 2020 6;35(6):e202000606. Epub 2020 Jul 6.

Department of Pulmonology, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Paris, France.

Purpose To analyze, in aged obese patients, the weight loss, comorbidity control, and safety postoperative complications of bariatric surgery by Roux-en-Y gastric bypass technique. Methods Twenty-seven patients who underwent laparoscopic weight-reducing gastroplasty with Roux-en-Y gastric bypass to treat obesity were included. All patients were ≥ 60 years old at the time of surgery. Read More

Acta Med Hist Adriat 2020 Jun;18(1):184-187

Department of Social Sciences and Medical Humanities, University of Rijeka, Faculty of Medicine, E-mail:

The former villa of Archduke Joseph, today's State Archives in Rijeka, as a building of the protected cultural property of the City of Rijeka, once again hosted an international scientific conference "Rijeka and its Citizens in Medical History". It was the nineteenth scientific conference organized by the Croatian Scientific Society for the History of Health Culture, the State Archive in Rijeka and University of Rijeka, Faculty of Medicine. The first session closely connected the Rijeka part of medical historiography, with an emphasis on professions and health care systems of Rijeka, connecting it with its immediate surroundings, people and institutions on whose foundations modern Rijeka medicine rests, while the second session contained topics of wider historical medical range. Read More

Acta Med Hist Adriat 2020 Jun;18(1):165-176

Department of General and Oncological Surgery, Clinical Hospital Center Rijeka, University of Rijeka, Faculty of Medicine, Krešimirova 42, 51000 Rijeka, Croatia. E-mail:

The authors have provided an in-depth review of the history of saline and silicone gel-filled breast implants. In the history of medicine, no devices have been more scrutinized and thoroughly studied than breast implants. Although we as plastic surgeons recognize and appreciate the benefits that our patients derive from these devices, society as a whole continues to remain skeptical. Read More

Acta Med Hist Adriat 2020 Jun;18(1):3149-164

Hrvatsko društvo za povijest medicine Hrvatskog liječničkog Zbora, Šubićeva 9, 10000 Zagreb. E-mail:

Medicine and physicians in Dubrovnik during the last two centuries, i.e. in the period after the dissolution of the Republic of Dubrovnik by Napoleon's Army, have attracted less interest among medical historians. Read More

Acta Med Hist Adriat 2020 Jun;18(1):129-148

Institut za turizam, Vrhovec 5, 10000 Zagreb, Hrvatska. E‑mail:

The health of officers (as well as the entire army) is exposed to additional risks due to the performance of various life-threatening tasks for the needs of the state. Therefore, it is not unusual for the state to take care of the health of its officers (as well as the army) through a system of Vojvodina medical care or specialised society through the construction of military or officer health resorts [Militärkurhaus / Offizierskurhaus] with the provision of medical/ health services. The subject of this paper is the relationship between architecture and the provision of military-medical services of officer/military health resorts built by the Society of the White Cross [Gesellschaft vom Weißen Kreuze] in Kvarner at the end of the 19th and the beginning of the 20th century. Read More

Acta Med Hist Adriat 2020 Jun;18(1):115-128

Department of Pediatric Surgery, General Hospital of Larissa, Larissa, Greece, 16, Tsopotou St, Volos 38222, Greece.

During the Byzantine Times, medicine and surgery developed as Greek physicians continued to practice in Constantinople. Healing methods were common for both adults and children, and pediatrics as a medical specialty did not exist. Already Byzantine hospitals became institutions to dispense medical services, rather than shelters for the homeless, which included doctors and nurses for those who suffered from the disease. Read More

Acta Med Hist Adriat 2020 Jun;18(1):105-114

Hrvatsko katoličko sveučilište u Zagrebu, Ilica 242, 10000 Zagreb / Klinika za ginekologiju i porodništvo Kliničke bolnice Sveti Duh u Zagrebu, Sveti Duh 64, 10000 Zagreb. E-mail:

Previously were published well-known data on Rijeka physician, Dr Ljubica Bosner, about her work in the Ogulin, Bjelovar, Petrinja and Rijeka hospitals during her excellent surgical and gynaecological and obstetric practice. The new and now accessible archives of personal and professional items complete incomplete and unknown biographical information. After her internship, Dr Bosner worked at a public county hospital in Velika Gorica as a secondary doctor at a well-known orthopaedic ward of that hospital. Read More

Acta Med Hist Adriat 2020 Jun;18(1):89-104

Ante Topića Mimare 23, 10090 Zagreb, Hrvatska. E-mail:

The paper presents a folk recipe collection manuscript written by an unknown author in Poljica area, in the 18th century. It is owned by the philologist, historian of literature and bibliophile, Josip Bratulic. Therefore, the author suggests that this recipe collection should bear the name Great folk medicine book from Poljica (Bratulic's folk medicine book). Read More

Acta Med Hist Adriat 2020 Jun;18(1):63-88

Arhiv za likovne umjetnosti, Hrvatska akademija znanosti i umjetnosti, Gundulićeva ulica 24, 10000 Zagreb, Hrvatska. E‑mail:

The paper presents the development and business of the chemical-pharmaceutical factory Rave PLC, founded in Zagreb in 1922. Based on archival and building documentation, professional and daily newspapers, and promotional material, the formation of the factory complex in the Zagreb industrial zone was reconstructed, its marketing strategy and its impact on the development of domestic drug production and hygiene and sanitary necessities were presented. As an important motive for its operations, the factory emphasized industrial independence, the national features of its business and the promotion of cooperation with young domestic industry. Read More

Acta Med Hist Adriat 2020 Jun;18(1):47-62

Division of Paleopathology, Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Via Roma 57, 56126 Pisa, Italy. E-mail:

The Spanish flu pandemic spread in 1918-19 and infected about 500 million people, killing 50 to 100 million of them. People were suffering from severe poverty and malnutrition, especially in Europe, due to the First World War, and this contributed to the diffusion of the disease. In Italy, Spanish flu appeared in April 1918 with several cases of pulmonary congestion and bronchopneumonia; at the end of the epidemic, about 450. Read More

Acta Med Hist Adriat 2020 Jun;18(1):27-46

Unit of History of Medicine and Bioethics, Sapienza University of Rome, Viale dell'Università 34/a, 00185 Rome, Italy. E-mail:

The article is the first step of a research project aimed at investigating new perspectives and aspects of Morgagni's role and work. His activities as a medical examiner and forensic doctor are yet to be truly discovered. Manuscripts, written by Morgagni when he was a forensic expert for the Health Magistrate of Venice, currently preserved at the City Library in Forli (Italy), shed light on a new aspect of his cultural background. Read More

Acta Med Hist Adriat 2020 Jun;18(1):15-26

University of Ljubljana, Faculty of Arts, Department of Ethnology and Cultural Anthropology, Zavetiška 5, SI - 1000 Ljubljana, Slovenia and University of Ljubljana, Faculty of Medicine, Institute for History of Medicine, Zaloška 7a, SI - 1000 Ljubljana, Slovenia.

The heritage of Slovenian house names and surnames reflects, among others, the former medicine and pharmaceutical occupations, midwifery, and folk medicine practices, and besides that, also health status and illnesses of people. Surnames, which are especially strongly intertwined with family, local and social history, are closely related to folk medicine and magic. Unlike house names (vulgo), which are the usual nicknames for physical and mental characteristics and abilities, surnames denote medical occupations and medicinal folk practice as such. Read More

Acta Med Hist Adriat 2020 Jun;18(1):9-14

Odjel za psihijatriju, Opća bolnica Karlovac, Ul. Andrije Štampara 3, 47000, Karlovac, Hrvatska / Katedra za društvene i humanističke znanosti u medicini, Sveučilište u Rijeci, Medicinski fakultet, Braće Branchetta 20, 51000 Rijeka, Hrvatska.

Searching for an answer whether medicine is a science or an art, especially in today's time when the emphasis is on the biotechnological aspects of treatment, the intention of this paper is to reflect on the outcomes of the encounter of medicine and art. Those that are recognised at least in the complementarity of the methodology, creating additional life values. By presenting authentic actions, this is a call for additional health improvement interventions, without allowing the biopsychosocial approach to human integrity to be forgotten. Read More

Acta Paediatr 2020 Jul 8. Epub 2020 Jul 8.

Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Acta Paediatr 2020 Jul 7. Epub 2020 Jul 7.

Department of Woman's and Child's Health, University of Padua, Padua, Italy.

Aim: To evaluate the relationship between clinical assessment of infant colour and oxygen saturation at birth in a low-resource setting.

Methods: Classification of infant colour (cyanotic, pink or unclear) by midwives was compared to pulse-oximeter data at 60-90-120-300 seconds after birth in 60 neonates.

Results: Overall, oxygen saturation increased over time (p<0. Read More

Acta Neurol Belg 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatrics, Institute of Post Graduate Medical Education and Research, Kolkata, India.

Acta Neurol Belg 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurosurgery, Tianjin Huanhu Hospital, 6 Jizhao Road, Tianjin, 300010, China.

Purpose: total removal of spinal hemangioblastomas with satisfactory clinical outcomes remains a challenge. We aimed to evaluate the surgical outcomes of our spinal hemangioblastomas patients, summarize our experiences with this condition and review-related literature.

Methods: records of 18 spinal hemangioblastoma patients who underwent microsurgical resection were analyzed retrospectively. Read More

Acta Neurol Belg 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou City, 215004, Jiangsu, China.

Prior studies had reported monocyte to high-density lipoprotein cholesterol ratio (MHR) as a new inflammation marker and stroke-associated pneumonia (SAP) is common after stroke. We investigated the predictive value of MHR for SAP in patients with acute ischemic stroke (AIS). A total of 803 AIS patients within 72 h after stroke were enrolled from April 2012 to January 2016 in Zhangjiagang TCM Hospital affiliated to the Nanjing University of Chinese Medicine. Read More

Acta Neurol Belg 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium.

Mikrochim Acta 2020 Jul 8;187(8):434. Epub 2020 Jul 8.

School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China.

A novel fluorescent and electron-deficient hybrid, N-methylated [Eu (pddb)phen(ox)] (Eu-MOF-Me) has been prepared via post-synthetic modification. Considering its special luminescent properties and cationic framework, Eu-MOF-Me is developed as a visualized fluorescent probe. Notably, water-stable Eu-MOF-Me exhibits advantages like good structural and fluorescent stability in a wide range of pH value (3. Read More

Acta Neurochir (Wien) 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurosurgery, University Hospital Ostrava, 17. Listopadu 1790/5, 70852, Ostrava, Czech Republic.

The authors present the unusual case of a 15-year-old boy with a primary empty sella caused by non-communicating hydrocephalus due to fourth ventricle outflow obstruction whose secondary symptoms of growth hormone deficiency and delayed puberty were successfully treated by endoscopic third ventriculocisternostomy (ETV). Hypopituitarism occurs only rarely in cases of hydrocephalus; rarer still are cases where hypopituitarism is the sole symptom of hydrocephalus. A primary empty sella may indicate elevated intracranial pressure; if the cause is non-communicating hydrocephalus, ETV is indicated as the preferred treatment modality. Read More

Mikrochim Acta 2020 Jul 7;187(8):433. Epub 2020 Jul 7.

College of Chemistry, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.

A photoelectrochemical platform for thrombin determination was developed based on Au-rGO-CuS as multiple signal amplification elements. CuInS QDs was used to sensitize burr-shape TiO (b-TiO) to obtain a strong photocurrent. Under the specific recognition between aptamer and thrombin, a sandwichlike structure was formed and the Au-rGO-CuS-labeled aptamer (S2@Au-rGO-CuS) was immobilized on the electrode surface. Read More

Mikrochim Acta 2020 Jul 7;187(8):432. Epub 2020 Jul 7.

Department of Gastrointestinal Surgery, The Second Clinical Medicine College (Shenzhen People's Hospital) of Jinan University, Shenzhen, 518020, Guangdong, China.

A label-free fluorescence method based on self-assembled DNA nanopompom has been developed for miRNA-21 detection. In the presence of miRNA-21, three DNA hairpin probes with split G-quadruplex assemble the DNA nanopompom. Based on the isothermal toehold-mediated DNA strand displacement reaction, the target miRNA can be catalytically recycled and trigger three DNA hairpin probes to self-assemble the DNA nanopompom and release the G-quadruplex. Read More

Acta Diabetol 2020 Jul 8. Epub 2020 Jul 8.

Diabetology Unit, Florence University, Florence, Italy.

Aim: To assess whether LC diets are associated with long-term improvement in glycemic control and weight loss in people with T2DM, and their cardiovascular and renal safety.

Methods: Meta-analysis of randomized controlled trials lasting more than 3 months, retrieved through extensive search on PubMed, Embase, ClinicalTrial.gov, Cochrane databases up to March 1st, comparing LC diets and balanced carbohydrate diets in people with T2DM. Read More

Acta Neuropathol 2020 Jul 8. Epub 2020 Jul 8.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, UK.

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 8. Epub 2020 Jul 8.

Department of Respiratory and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.

Isoliquiritigenin (ISL), a natural flavonoid derived from the root of liquorice, has been reported to possess anti-inflammatory and antioxidant activities. Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue; however, its effect on pulmonary fibrogenesis has not been demonstrated. In this study, we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 8. Epub 2020 Jul 8.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

The toxicity of synthetic pyrethroids has garnered attention, and studies have revealed that pyrethroids promote fat accumulation and lead to obesity in mice. Nevertheless, the effect of β-cypermethrin (β-CYP) on adipogenesis and its underlying mechanism remains largely unknown. In this study, mouse embryo fibroblasts 3T3-L1 cells were exposed to β-CYP, and the cell viability, intracellular reactive oxygen species (ROS) level, autophagy, and adipogenesis were assessed to investigate the roles of oxidative stress and autophagy in the toxic effects of β-CYP on adipogenesis. Read More

J Clin Med 2020 Jul 3;9(7). Epub 2020 Jul 3.

Department of Life, Health and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi 1, 67100 L'Aquila, Coppito, Italy.

In periodontitis patients, furcation defects are crucial sites to regenerate due to their complex anatomy. Various modern surgical techniques and use of biomaterials have been suggested in the literature. Among all, platelet-rich fibrin (PRF) has potential in tissue regeneration thanks to its role in the release of growth factors. Read More

Cancers (Basel) 2020 Jul 3;12(7). Epub 2020 Jul 3.

Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

Background: Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature.

Methods: A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB. Read More

Biochim Biophys Acta Gen Subj 2020 Jul 4:129677. Epub 2020 Jul 4.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.

Background: The process of malignant transformations of many tumour cases is still unclear and more specific experimental approaches are necessary. The detailed identification of the pathological changes may help in the therapy progression through the development of drugs with more selective action.

Methods: In this study, the AFM-IR nanospectroscopy was applied for the first time to the pleomorphic adenoma (TM) and the marginal tissue characterizations. Read More

Biochim Biophys Acta Gen Subj 2020 Jul 4:129680. Epub 2020 Jul 4.

Chemical Biology Unit, Institute of Nano Science and Technology, Habitat Centre, Sector- 64, Mohali, Punjab 160062, India. Electronic address:

Background: Bacterial microcompartment represents the only reported category of prokaryotic organelles that are capable of functioning as independent bioreactors. In this organelle, a biochemical pathway with all the enzyme machinery is encapsulated within an all protein shell. The shell proteins and the enzymes have distinct structural features. Read More

Acta Biomater 2020 Jul 4. Epub 2020 Jul 4.

Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts, 02215. Electronic address:

Tensional homeostasis is widely recognized to exist at the length scales of organs and tissues, but the cellular length scale mechanism for tension regulation is not known. In this study, we explored whether tensional homeostasis emerges from the behavior of the individual focal adhesion (FA), which is the subcellular structure that transmits cell stress to the surrounding extracellular matrix. Past studies have suggested that cell contractility builds up until a certain displacement is achieved, and we thus hypothesized that tensional homeostasis may require a threshold level of substrate displacement. Read More

Acta Biomater 2020 Jul 4. Epub 2020 Jul 4.

School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China; Sino-Singapore International Joint Research Institute, Guangzhou, 510555, China. Electronic address:

Self-healing hydrogels can heal themselves on the damaged sites, which opens up a fascinating way for enhancing lifetimes of materials. Polypeptide/poly(amino acid) is a class of polymers in which natural amino acid monomers or derivatives are linked by amide bonds with a stable and similar secondary structure as natural proteins (α-helix or β-fold). They have the advantages of nontoxicity, biodegradability, and low immunogenicity as well as easy modification. Read More

Acta Trop 2020 Jul 4:105619. Epub 2020 Jul 4.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

Chikungunya virus (CHIKV) is a zoonotic arthropod-borne virus that has caused several outbreaks in tropical and subtropical areas worldwide during the last 50 years. The virus is known to target different human cell types throughout the course of infection including epithelial and endothelial cells, fibroblasts, primary monocytes and monocyte-derived macrophages (MDMs). The two latter are phagocytic cell populations of the innate immune system which are involved in some aspects of CHIKV pathogenesis. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Department of Gastrointestinal Surgery, Yijishan Hospital of Wannan Medical College, Wuhu 241000, China.

HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Biomineralization, especially shell formation, is a sophisticated process regulated by various matrix proteins. Pinctada fucata chitinase-like protein 1 (Pf-Clp1), which belongs to the GH18 family, was discovered by our group using in-depth proteomic analysis. However, its function is still unclear. Read More