Search Our Scientific Publications & Authors

Acta Obstet Gynecol Scand 2022 May 24. Epub 2022 May 24.

Department of Pediatrics and Community Health Sciences, Cummings School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Introduction: Hypertensive disorders of pregnancy occur in approximately 7%-10% of pregnancies and are associated with adverse maternal cardiovascular health outcomes across the lifespan. In contrast, breastfeeding has been associated with a reduction in cardiovascular risk factors in a dose-dependent manner. Despite the potential protective effects of lactation on cardiovascular risk, how hypertensive disorders of pregnancy relate to breastfeeding practices and experiences is not well understood. Read More

Acta Obstet Gynecol Scand 2022 May 23. Epub 2022 May 23.

Department for the History, Philosophy, and Ethics of Medicine, Centre for Health and Society, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.

Acta Obstet Gynecol Scand 2022 May 22. Epub 2022 May 22.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

Introduction: The association between intrahepatic cholestasis of pregnancy (ICP) and maternal lipid metabolism remains unknown. This systematic review and meta-analysis aimed to evaluate the association between ICP and maternal lipid metabolism.

Material And Methods: We systematically searched Medline, Embase and the Cochrane Library (up to December 11, 2021) to identify relevant studies that investigated ICP and maternal plasma lipid concentrations. Read More

Acta Obstet Gynecol Scand 2022 May 18. Epub 2022 May 18.

Obstetrics and Gynecology, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction: Placental abruption can result in serious perinatal morbidity and mortality. However, it is not clear whether placental abruption could lead to neonatal anemia, as a direct relationship has not been described yet. The objective of this study is to investigate whether there is a relationship between occurrence of placental abruption and neonatal anemia. Read More

Acta Obstet Gynecol Scand 2022 May 15. Epub 2022 May 15.

Department of Obstetrics and Gynecology, Danderyd Hospital, Stockholm, Sweden.

Acta Obstet Gynecol Scand 2022 May 11. Epub 2022 May 11.

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

Introduction: The incidence of ectopic pregnancy is up to four times higher after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) than in spontaneous pregnancies, and the risk of ectopic pregnancy is increased by tubal factor infertility and the transfer of multiple embryos. However, the effect of embryo quality on the probability of ectopic pregnancy has not been investigated until now and it is not clear whether ovarian stimulation parameters affect the incidence of ectopic pregnancy.

Material And Methods: An historical cohort study of 15 006 clinical pregnancies (diagnosed by ultrasound at 6-8 gestational weeks) after non-donor IVF/ICSI with fresh embryo transfer (n = 8952) or frozen-thawed embryo transfer (n = 6054). Read More

Acta Obstet Gynecol Scand 2022 May 11. Epub 2022 May 11.

Department of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway.

Introduction: Second-degree perineal tears can vary widely as to the extent of trauma, which may be relevant for women's pelvic floor health postpartum. However, the short- and long-term consequences of second-degree perineal tears are poorly understood, likely due to the lack of a detailed classification system. Such a classification system for second-degree tears has been suggested but the inter-rater agreement has not yet been assessed. Read More

Acta Obstet Gynecol Scand 2022 Jun 11;101(6):693-698. Epub 2022 May 11.

Department of Gynecology and Obstetrics, Aalborg University Hospital, Aalborg, Denmark.

Introduction: Up to 39% of women in Denmark do not participate regularly in the cervical cancer screening program and initiatives to increase participation are called upon. The primary aim of this study was to describe previous screening history and characteristics of women attending screening in a walk-in clinic. Furthermore, we wanted to investigate barriers to cervical cancer screening. Read More

Acta Obstet Gynecol Scand 2022 May 6. Epub 2022 May 6.

San Antonio, TX, USA.

Acta Obstet Gynecol Scand 2022 May 5. Epub 2022 May 5.

Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

Introduction: Cryopreservation of ovarian tissue with subsequent transplantation is an efficient option for restoring fertility in women at risk of premature ovarian failure. The association between infertility and endometriosis is well recognized. Although endometriosis usually ends with the onset of natural or iatrogen menopause due to declining estrogen levels, endometriosis can in rare cases occur after menopause. Read More

Acta Obstet Gynecol Scand 2022 May 5. Epub 2022 May 5.

Department of Obstetrics and Gynecology and Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Acta Obstet Gynecol Scand 2022 May 3. Epub 2022 May 3.

Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain.

Introduction: The association between preeclampsia and coronavirus disease 2019 (COVID-19) is under study. Previous publications have hypothesized the existence of shared risk factors for both conditions or a deficient trophoblastic invasion as possible explanations for this association. The primary aim of this study was to examine baseline risk factors measured in the first-trimester combined screening for preeclampsia in pregnant women with COVID-19 compared with the general population. Read More

Acta Obstet Gynecol Scand 2022 May 3. Epub 2022 May 3.

Evaluation of Health Technologies and Medical Practices (METRICS) - ULR 2694, University of Lille, Centre Hospitalier Universitaire de Lille, Lille, France.

Introduction: This study evaluated the association between fetal heart rate variability (HRV) and the occurrence of hypoxic-ischemic encephalopathy in a fetal sheep model.

Material And Methods: The experimental protocol created a hypoxic condition with repeated cord occlusions in three phases (A, B, C) to achieve acidosis to pH <7.00. Read More

Acta Obstet Gynecol Scand 2022 May 2. Epub 2022 May 2.

Department of Obstetrics and Gynecology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.

Introduction: Magnesium sulfate is used world-wide to treat pregnant women at imminent risk of preterm delivery in order to protect the brain of the premature infant. Previous research has shown that magnesium sulfate decreases the risk of cerebral palsy by ~30% in infants born preterm. Despite this, the dosage required for optimal neuroprotection remains unknown. Read More

Acta Obstet Gynecol Scand 2022 Jun 28;101(6):657-692. Epub 2022 Apr 28.

Department of Obstetrics and Gynecology, Nordsjaellands Hospital, Institute of Clinical Medicine, University of Copenhagen, Hillerød, Denmark.

In recent years, LASER has been introduced as a minimally invasive treatment for a broad range of vaginal and vulvar symptoms and diseases. However, the efficacy and safety of vaginal and vulvar LASER has continuously been questioned. The aim of this study is to create an overview of the current literature and discuss the controversies within the use of LASER for genitourinary syndrome of menopause, vulvovaginal atrophy, urinary incontinence and lichen sclerosus. Read More

Acta Obstet Gynecol Scand 2022 Jun 28;101(6):608-615. Epub 2022 Apr 28.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Introduction: Understanding whether human papillomavirus (HPV) may establish latency in the uterine cervix is important. A better understanding of HPV natural history is useful for clinical counseling of women attending screening and to accurately inform health prevention strategies such as screening and HPV vaccination. We evaluated the extent of latent HPV infections in older women with a history of abnormal cytology. Read More

Acta Obstet Gynecol Scand 2022 Jun 26;101(6):597-607. Epub 2022 Apr 26.

Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: In this review and meta-analysis we aimed to investigate whether human papilloma virus (HPV) vaccination administered after excisional treatment of cervical intraepithelial neoplasia (CIN) is associated with a reduced risk of recurrence of CIN grade 2 or worse (CIN2+).

Material And Methods: We performed a systematic literature search in three online databases through June 2021. Observational studies and randomized controlled trials (RCTs) were eligible for inclusion if the prophylactic HPV vaccine was administered after excisional treatment for histologically verified CIN. Read More

Acta Obstet Gynecol Scand 2022 Apr 25. Epub 2022 Apr 25.

Department of Obstetrics and Gynecology, University of Campinas, Campinas, Brazil.

Acta Obstet Gynecol Scand 2022 Apr 25. Epub 2022 Apr 25.

Department of Cardiology, Oslo University Hospital, Oslo, Norway.

Introduction: Beta-blockers are prescribed for many pregnant women with heart disease, but whether there is a dose-dependent effect on fetal growth remains to be examined. We aimed to investigate if antenatal beta-blocker use and dose were associated with delivering a small-for-gestational-age infant among women with heart disease.

Material And Methods: Our cohort included women with heart disease who delivered at Oslo University Hospital between 2006 and 2015. Read More

Acta Obstet Gynecol Scand 2022 Jun 22;101(6):649-656. Epub 2022 Apr 22.

Department of Development and Regeneration, Faculty of Medicine, Group Biomedical Sciences, KU Leuven, Leuven, Belgium.

Vaginal natural orifice transluminal endoscopic surgery (NOTES) is a novel technique for minimally invasive gynecological surgery. Adequate training and standardization are key elements to patient safety and quality of care. Based on consensus statements and expert opinion; we report a step-by-step guidance for hysterectomy via natural orifice transluminal endoscopy. Read More

Acta Obstet Gynecol Scand 2022 Jun 22;101(6):624-627. Epub 2022 Apr 22.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Traditional null hypothesis significance testing (NHST) incorporating the critical level of significance of 0.05 has become the cornerstone of decision-making in health care, and nowhere less so than in obstetric and gynecological research. However, such practice is controversial. Read More

Acta Obstet Gynecol Scand 2022 May;101(5):482-483

Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Acta Obstet Gynecol Scand 2022 Apr 20. Epub 2022 Apr 20.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Acta Obstet Gynecol Scand 2022 Apr 20. Epub 2022 Apr 20.

Fetal Medicine Unit, Women's Centre, John Radcliffe Hospital, Oxford, UK.

Introduction: Ultrasound assessment of fetuses subjected to hyperglycemia is recommended but, apart from increased size, little is known about its interpretation, and the identification of which large fetuses of diabetic pregnancy are at risk is unclear. Newer markers of adverse outcomes, abdominal circumference growth velocity and cerebro-placental ratio, help to predict risk in non-diabetic pregnancy. Our study aims to assess their role in pregnancies complicated by diabetes. Read More

Acta Obstet Gynecol Scand 2022 Apr 17. Epub 2022 Apr 17.

Department of Public Health, Aarhus University, Aarhus, Denmark.

Introduction: Due to diagnostic challenges, normalization of symptoms and an overall lack of awareness among both patients and physicians, endometriosis is an underdiagnosed disease. This can result in delayed treatment and potentially worsening of the disease. Despite initiatives, such as patients' support organizations and specialized endometriosis referral centers, differences in awareness, socioeconomic factors and lifestyle, combined with varying distances to specialized referral centers, could result in regional differences in the degree of underdiagnosing. Read More

Acta Obstet Gynecol Scand 2022 Apr 11. Epub 2022 Apr 11.

Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Introduction: Surgical complications after primary or interval debulking surgery in advanced ovarian cancer were investigated and associations with patient characteristics and surgical outcomes were explored.

Material And Methods: A population-based cohort study including all women with ovarian cancer, FIGO III-IV, treated with primary or interval debulking surgery, 2013-2017. Patient characteristics, surgical outcomes and complications according to the Clavien-Dindo (CD) classification system ≤30 days postoperatively, were registered. Read More

Acta Obstet Gynecol Scand 2022 Apr 7. Epub 2022 Apr 7.

Norwegian Research Center for Women's Health, Oslo University Hospital, Oslo, Norway.

Introduction: A peripartum hysterectomy is typically performed as a lifesaving procedure in obstetrics to manage severe postpartum hemorrhage. Severe hemorrhages that lead to peripartum hysterectomies are mainly caused by uterine atony and placenta accreta spectrum disorders. In this study, we aimed to estimate the incidence, risk factors, causes and management of severe postpartum hemorrhage resulting in peripartum hysterectomies, and to describe the complications of the hysterectomies. Read More

Acta Obstet Gynecol Scand 2022 Apr 7. Epub 2022 Apr 7.

Department of Gynecology and Obstetrics, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark.

Introduction: Preeclampsia is associated with adverse maternal and neonatal outcomes. It is unclear whether multivitamin use reduces the risk of preeclampsia. This systematic review and meta-analysis aimed to evaluate the association between multivitamin use and the risk of preeclampsia. Read More

Acta Obstet Gynecol Scand 2022 Apr 5. Epub 2022 Apr 5.

Department of Obstetrics and Gynecology, Aalborg University Hospital, Aalborg, Denmark.

Acta Obstet Gynecol Scand 2022 Jun 5;101(6):616-623. Epub 2022 Apr 5.

Gødstrup Hospital, NIDO Denmark, Gødstrup, Denmark.

Introduction: In Denmark, women with a future childbearing desire diagnosed with cervical intraepithelial neoplasia grade 2 (CIN2) are recommended active surveillance instead of excisional treatment. However, we have limited and contradictory knowledge about how active surveillance of CIN2 may affect women emotionally. The aim of this study was to explore thoughts and emotional responses in women undergoing active surveillance of CIN2 and to explore how active surveillance may affect women's future childbearing desire. Read More