Search Our Scientific Publications & Authors

Acta Neurol Scand 2022 May 25. Epub 2022 May 25.

Department of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Previous studies with a limited sample size suggested more severe dopaminergic transporter (DAT) lesions in the striatum of progressive supranuclear palsy (PSP) than those in Parkinson's disease (PD) and multiple system atrophy-parkinsonism (MSA-P). However, few studies had taken various subtypes of PSP into consideration, making the reanalysis of DAT imaging in larger PSP cohort with various subtypes in need.

Objectives: To compare the dopaminergic lesion patterns of PSP with MSA-P and PD, and to explore the specific striatal subregional patterns of different PSP subtypes. Read More

Acta Neurol Scand 2022 May 25. Epub 2022 May 25.

Department of Neuromuscular Disease, Queen Square UCL Institute of Neurology and the National Hospital of Neurology and Neurosurgery, London, UK.

Traditionally, neurophysiology is the primary diagnostic and prognostic biomarker in peripheral neuropathy clinical practice; however, it may lack responsiveness in the context of slowly progressive neuropathies and where there is significant axonal damage. The development of ultrasensitive platforms for measuring serum proteins at the lower limit of detection of traditional ELISA techniques has transformed the field of blood biomarkers of peripheral neuropathy. A variety of blood biomarkers have been identified from inflammatory cytokines and apokines in diabetic neuropathy through to neuron-specific proteins such as neurofilament light chain, Schwann cell-specific proteins such as TMPRSS5 and microRNAs in other acquired and hereditary neuropathies. Read More

Acta Neurol Scand 2022 May 25. Epub 2022 May 25.

Shiraz University of Medical Sciences, Shiraz, Iran.

Deep brain stimulation (DBS) is a well-defined treatment for motor symptoms in advanced PD. Although several studies have investigated the DBS effect on non-motor symptoms (NMS), controversial results exist regarding this matter. The aim of this meta-analysis and systematic review was to assess the bilateral subthalamic nucleus (STN) DBS effect on NMS of PD. Read More

Acta Neurol Scand 2022 May 24. Epub 2022 May 24.

Department of Neurology, Hacettepe University Hospitals, Ankara, Turkey.

Objectives: In the absence of widely accepted criteria, determining when a patient with Parkinson's disease (PD) may benefit from more advanced treatments such as device-aided therapy (DAT) so far remains a matter of physician judgment. This analysis investigates how classification of PD varies across countries relative to measures of disease severity.

Materials And Methods: The OBSERVational, cross-sEctional PD (OBSERVE-PD) study included consecutive patients with PD at centers that offer DATs in 18 countries. Read More

Acta Neurol Scand 2022 May 20. Epub 2022 May 20.

Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.

Objectives: The Austrian Prehospital Stroke Scale (APSS) score was developed to predict large vessel occlusion (LVO) and improve prehospital transportation triage. Its accuracy has been previously analyzed retrospectively. We now aimed to investigate the accuracy, as well as the impact of the implementation of a triage strategy using this score on treatment times and outcome in a prospective study. Read More

Acta Neurol Scand 2022 May 13. Epub 2022 May 13.

Neurology & Neurophysiology Center, Vienna, Austria.

Acta Neurol Scand 2022 May 12. Epub 2022 May 12.

Department of Neurology, Centro Hospitalar Universitário de São João, E.P.E., Porto, Portugal.

Background: Congenital myopathies (CM) were traditionally classified according to the muscle histopathological features, but in recent years, molecular diagnosis has become increasingly important. CM may present a wide phenotype variability, and while adult-onset CM have been increasingly recognized, substantial diagnostic delays are still reported.

Objectives: To describe a cohort of adult CM patients, including clinical, genetic, and histopathological features, and further characterize the subgroup of adult-diagnosed patients. Read More

Acta Neurol Scand 2022 May 11. Epub 2022 May 11.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Aims: To study incident narcolepsy in first- and second-generation immigrant groups using Swedish-born individuals and native Swedes as referents.

Methods: The study population included all individuals registered and alive in Sweden at baseline. Narcolepsy was defined as having at least one registered diagnosis of narcolepsy in the Swedish National Patient Register. Read More

Acta Neurol Scand 2022 May 4. Epub 2022 May 4.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: To explore dynamic alterations of cortical thickness before and after successful anterior temporal lobectomy (ATL) in patients with unilateral mesial temporal lobe epilepsy (mTLE).

Materials And Methods: High-resolution T1-weighted MRI was obtained in 28 mTLE patients who achieved seizure freedom for at least 24 months after ATL and 29 healthy controls. Patients were scanned at five timepoints, including before surgery, 3, 6, 12 and 24 months after surgery. Read More

Acta Neurol Scand 2022 May 2. Epub 2022 May 2.

Danish Headache Center, Rigshospitalet-Glostrup, University of Copenhagen, Copenhagen, Denmark.

Objective: Spontaneous intracranial hypotension (SIH) manifests as orthostatic headache, which can be confirmed by radiological signs of low intracranial pressure on magnetic resonance imaging of the brain. The most common mechanisms of SIH are ruptured meningeal diverticula, ventral dural tears and CSF-venous fistulas. SIH is associated with connective tissue disorders, and cases of SIH onset after trivial trauma have been reported. Read More

Acta Neurol Scand 2022 Apr 26. Epub 2022 Apr 26.

Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: Glioblastoma is the most aggressive primary brain tumour in adults. The rapid decline of physical and cognitive functions is likely to affect patients and relatives during the entire course of disease. The aim of this study was to describe and compare (a) health-related quality of life (HRQoL) and psychological symptoms between patients with glioblastoma and their relatives, and (b) HRQoL between patients and a general population over time. Read More

Acta Neurol Scand 2022 Apr 26. Epub 2022 Apr 26.

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Although clinical examinations, neuroimaging, and cerebrospinal fluid analyses are the most important ways to evaluate the impact of HIV infection on the brain and in diagnosis of opportunistic infections, several blood biomarkers including HIV RNA concentrations, CD4 +T-cell count, and neurofilament light chain protein (NfL) concentration, along with tests for opportunistic infections can provide important information for clinical decisions. Read More

Acta Neurol Scand 2022 Apr 25. Epub 2022 Apr 25.

UK Dementia Research Institute at UCL, London, UK.

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the single commonest cause of dementia. Many other diseases can, however, cause dementia, and differential diagnosis can be challenging, especially in early disease stages. For most neurodegenerative dementias, accumulation of brain pathologies starts many years before clinical onset; the ability to detect these pathologies paves the way for targeted disease-modifying prevention trials. Read More

Acta Neurol Scand 2022 Apr 25. Epub 2022 Apr 25.

Department of Radiology, Clínico San Carlos, Health Research Institute "San Carlos" (IdISSC), Universidad Complutense de Madrid, Madrid, Spain.

Background: Olfactory dysfunction is common during SARS-CoV-2 infection. The pathophysiology of the persistence of this symptom and the potential relationship with central nervous system involvement is unknown.

Aim Of The Study: To evaluate the neural correlates of persistent olfactory dysfunction in a series of patients with post-COVID syndrome. Read More

Acta Neurol Scand 2022 Apr 24. Epub 2022 Apr 24.

Department of Neurology, Clinical Research Center of Neurological Diseases, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Objective: To determine the function of each type of peripheral nerve fiber and investigate the possible role of levodopa (LD) in peripheral neuropathy (PN) in Parkinson's disease (PD) patients.

Methods: We enrolled 60 patients with idiopathic PD. All PD patients were divided into three groups: levodopa exposure >3 years (LELD), levodopa exposure ≤3 years (SELD) and de novo patients with PD (NOLD). Read More

Acta Neurol Scand 2022 Apr 21. Epub 2022 Apr 21.

Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

Objectives: Thrombolytic treatment in acute ischemic stroke (AIS) reduces stroke-related disability. Nearly 40% of all patients with AIS (<4.5 h) receive thrombolysis, but there is a large variation in the use between hospitals. Read More

Acta Neurol Scand 2022 Apr 16. Epub 2022 Apr 16.

Department of Neurosurgery, Ina Central Hospital, Ina, Japan.

Objectives: Intracranial branch atheromatous disease often results in progressive motor deficits in the lenticulostriate arteries (LSA). In some patients with LSA infarction, magnetic resonance imaging (MRI) revealed single lesions at the LSA origin from the middle cerebral artery spreading in a scattered manner toward the distal area. This study aimed to elucidate the clinical characteristics of such cases. Read More

Acta Neurol Scand 2022 Apr 11. Epub 2022 Apr 11.

Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Robust and accessible biomarkers are greatly needed in epilepsy. Diagnostic and prognostic precision in the clinic needs to improve, and there is a need for objective quantification of seizure burden. In recent years, there have been advances in the development of accessible and cost-effective blood-based biomarkers in neurology, and these are increasingly studied in epilepsy. Read More

Acta Neurol Scand 2022 Apr 7. Epub 2022 Apr 7.

Division of Neuropsychiatry, Centro de Ciências Médicas-Universidade Federal de Pernambuco, Recife, Brazil.

While neurologic complications are frequently reported among patients with COVID-19 in the general population, they are unknown in pregnant women. This paper summarizes the case reports of pregnant women with confirmed SARS-CoV-2 infection plus a specified neurologic diagnosis. Until November 2021, 18 case reports were found. Read More

Acta Neurol Scand 2022 Apr 6. Epub 2022 Apr 6.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Objective: Among patients assessed by the emergency medical service (EMS) and hospitalized with a final diagnosis of stroke, to describe delays, patient characteristics, actions taken and outcome in relation to the early recognition of stroke by the EMS clinician.

Methods: Patients admitted to any of six stroke units in Region Västra Götaland, Sweden, with a final diagnosis of stroke from 1 January 2013 to 31 December 2015 were included. Data on follow-up were retrieved from the Swedish Stroke Register. Read More

Acta Neurol Scand 2022 Apr 5. Epub 2022 Apr 5.

Neurocenter, Turku Brain Injury Center, Turku University Hospital and University of Turku, Turku, Finland.

Blood-based biomarkers are promising tools to complement clinical variables and imaging findings in the diagnosis, monitoring and outcome prediction of traumatic brain injury (TBI). Several promising biomarker candidates have been found for various clinical questions, but the translation of TBI biomarkers into clinical applications has been negligible. Measured biomarker levels are influenced by patient-related variables such as age, blood-brain barrier integrity and renal and liver function. Read More

Acta Neurol Scand 2022 Apr 4. Epub 2022 Apr 4.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Objectives: To establish a model in order to predict the functional outcomes of patients with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis and identify significant predictive factors using a random forest algorithm.

Methods: Seventy-nine patients with confirmed LGI1 antibodies were retrospectively reviewed between January 2015 and July 2020. Clinical information was obtained from medical records and functional outcomes were followed up in interviews with patients or their relatives. Read More

Acta Neurol Scand 2022 Jun 31;145(6):649-657. Epub 2022 Mar 31.

Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Patients with chronic subdural hematoma (CSDH) can have transient neurological deficits deficit (TND) mimicking transient ischemic attacks. The prevalence of TNDs in CSDH varies between 1%-24%, depending on TND definition. Despite this high prevalence the pathophysiology of TND in CSDH is not clear in many cases. Read More

Acta Neurol Scand 2022 Jun 31;145(6):770-785. Epub 2022 Mar 31.

Research Centre for Hauora and Health, Massey University, Wellington, New Zealand.

Objectives: To assess whether sports, physical trauma and emotional trauma are associated with motor neurone disease (MND) in a New Zealand case-control study (2013-2016).

Methods: In total, 321 MND cases and 605 population controls were interviewed collecting information on lifetime histories of playing sports, physical trauma (head injury with concussion, spine injury) and emotional trauma (14 categories). ORs were estimated using logistic regression adjusting for age, sex, ethnicity, socioeconomic status, education, smoking status, alcohol consumption and mutually adjusting for all other exposures. Read More

Acta Neurol Scand 2022 Jun 21;145(6):743-752. Epub 2022 Mar 21.

Department of Neurology, Rehabilitation Medicine, Memory Disorders, and Geriatrics, Skåne University Hospital, Lund, Sweden.

Background: Few studies have investigated the health-related quality of life (HRQoL), resource use and costs in patients with late-stage Parkinson's disease (PD), and data from the Swedish setting are scarce.

Objectives: First, we analyse the HRQoL in late-stage PD in Sweden. Second, we analyse the resource use and costs per severity level. Read More

Acta Neurol Scand 2022 Mar 20. Epub 2022 Mar 20.

HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Finland.

Objectives: The genetic background of vascular cognitive impairment (VCI) is poorly understood compared to other dementia disorders. The aim of the study was to investigate the genetic background of VCI in a well-characterized Finnish cohort.

Materials & Methods: Whole-exome sequencing (WES) was applied in 45 Finnish VCI patients. Read More

Acta Neurol Scand 2022 06 20;145(6):789-790. Epub 2022 Mar 20.

Department of Biomedical, Metabolic Neural Sciences, University of Modena, Modena, Italy.

Acta Neurol Scand 2022 Jun 20;145(6):762-769. Epub 2022 Mar 20.

1st Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, Eginition Hospital, Athens, Greece.

Background: Multiple pathologies may underlie corticobasal syndrome (CBS), including Alzheimer's disease (AD). Dopamine transporter density imaging with Ioflupane I SPECT (DaTscan) may be normal in CBS. No studies to date have examined the relationship between DaTscan status and underlying pathology in CBS. Read More

Acta Neurol Scand 2022 Jun 17;145(6):753-761. Epub 2022 Mar 17.

Cornwall Partnership NHS Foundation Trust, Truro, UK.

Objectives: Intellectual disability (ID) and epilepsy are independent risk factors for osteoporosis. Diverse predisposing factors influence this, for example in ID, genetics and poor nutrition and in epilepsy, anti-seizure medication (ASM). Around 25% people with ID have epilepsy, majority treatment resistant. Read More

Acta Neurol Scand 2022 Jun 11;145(6):737-742. Epub 2022 Mar 11.

Department of Clinical Neurosciences, Neurology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Background: Status epilepticus (SE) persisting despite two anti-seizures medications (ASM) and anesthetics is labeled super refractory (SRSE), correlating with important morbidity and mortality. Its treatment relies on expert opinions. Due to its pharmacological properties, ketamine (KET) has received increasing attention, but data are essentially retrospective. Read More