1,036 results match your criteria Acta Microbiologica Et Immunologica Hungarica[Journal]


Linezolid decreases Staphylococcus aureus biofilm formation by affecting the IcaA and IcaB proteins.

Acta Microbiol Immunol Hung 2022 May 17. Epub 2022 May 17.

Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.

Background: The ica gene of Staphylococcus aureus (S. aureus) plays a vital role in its growth and biofilm formation. Among them, IcaA and IcaB are critical proteins for synthesizing extracellular polysaccharides and biofilms in S. Read More

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Characterization of imipenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates in a Moroccan hospital.

Acta Microbiol Immunol Hung 2022 May 11. Epub 2022 May 11.

1 Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, Rabat, Morocco.

Acinetobacter baumannii and Pseudomonas aeruginosa are two pathogens with an important power of adaptation to antibiotics thus, both pose a real public health problem. Our study investigated epidemiological characteristics, antibiotic sensitivity profile and resistance genes of imipenem resistant A. baumannii and P. Read More

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Identification of mutations in rpoB, pncA, embB, and ubiA genes among drug-resistant Mycobacterium tuberculosis clinical isolates from Iran.

Acta Microbiol Immunol Hung 2022 Apr 22. Epub 2022 Apr 22.

1 Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mycobacterium tuberculosis resistant to effective first-line drugs (FLDs) has challenged national and global tuberculosis control programs. This study aimed to identify mutations in 4 genes related to rifampin, pyrazinamide, and ethambutol resistance among clinical isolates of M. tuberculosis from southwestern Iran. Read More

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Serum fetuin-A level is independent of Helicobacter pylori postinfection status in systemic lupus erythematosus.

Acta Microbiol Immunol Hung 2022 Apr 21. Epub 2022 Apr 21.

1 Department of Family Medicine, Semmelweis University, Budapest, Hungary.

Helicobacter pylori is a common pathogen causing gastric inflammation and malignancy. Fetuin-A is a multifunctional protein that is involved in the regulation of calcification, insulin resistance and inflammation. Reports on serum levels of fetuin-A in acute H. Read More

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Interaction between Clostridium species and microbiota to progress immune regulation.

Acta Microbiol Immunol Hung 2022 Apr 7. Epub 2022 Apr 7.

1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Gut microbiota can interact with the immune system through direct or indirect pathways. In the indirect pathway, gut microbiota produces metabolites such as short chain fatty acids (SCFAs), which may modulate the immune response. SCFAs reduce inflammation, repair intestinal barrier, and induce propagation of specific immune cells, e. Read More

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A pan-resistant Myroides odoratimimus catheter-related bacteremia in a COVID-19 patient and review of the literature.

Acta Microbiol Immunol Hung 2022 Mar 21. Epub 2022 Mar 21.

2 Department of Medical Microbiology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Myroides spp. are opportunistic environmental Gram-negative bacteria. These affect mostly immunocompromised hosts and generally lead to soft tissue, and urinary tract infections. Read More

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Changes in molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in the intensive care units of a Greek hospital, 2018-2021.

Acta Microbiol Immunol Hung 2022 Mar 17. Epub 2022 Mar 17.

1 Department of Microbiology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.

The spread of multi-drug resistant (MDR) Gram-negative bacteria, including Klebsiella pneumoniae, constitutes a global threat. The most frequent mechanism of acquired carbapenem resistance is the production of carbapenemases, especially KPC, NDM, VIM, IMP and OXA-48. We analyzed the epidemiological trend of carbapenem resistance genes of carbapenem-resistant K. Read More

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Ralstonia pickettii bacteremia in a cardiac surgery patient in Belgrade, Serbia.

Acta Microbiol Immunol Hung 2022 Mar 17. Epub 2022 Mar 17.

1 University of Belgrade - Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade, Serbia.

Ralstonia pickettii is an opportunistic bacterium found in the water environment with an increasing incidence as a nosocomial pathogen. The objectives of this study were to describe R. pickettii bacteremia in a cardiac surgery patient and to evaluate its ability to grow in a saline solution and to form biofilm. Read More

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Association of fluoroquinolone resistance and ESBL production in hypervirulent Klebsiella pneumoniae ST11 and ST893 in Iran.

Acta Microbiol Immunol Hung 2022 Feb 22. Epub 2022 Feb 22.

2 Division of Clinical Microbiology, Department of Laboratory Medicine, Amin Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

The spread of multidrug resistance in Klebsiella pneumoniae is a serious threat to the public health. In this study, the prevalence of fluoroquinolone resistance and virulence determinants among ESBL-producing K. pneumoniae isolates was investigated. Read More

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February 2022

Characteristics in the whole-genome sequence of Klebsiella pneumoniae ST147 from Turkey.

Acta Microbiol Immunol Hung 2022 Feb 22. Epub 2022 Feb 22.

4 Recep Tayyip Erdoğan University, Department of Biology, 53020, Rize, Turkey.

The study aimed to analyze antibiotic resistance determinants in a carbapenem-resistant Klebsiella pneumoniae by whole-genome sequencing (WGS). K. pneumoniae was isolated from a urine sample and it was characterized by 16S rDNA sequencing in Turkey. Read More

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February 2022

Corrigendum: The role of microbiota and immune system crosstalk in cancer development and therapy.

Acta Microbiol Immunol Hung 2022 Feb 16. Epub 2022 Feb 16.

3 Department of Immunology, Pasteur Institute of Iran, Tehran, Iran.

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February 2022

Seroprevalence of SARS-CoV-2 antibodies among primary healthcare workers in the Republic of Srpska, Bosnia & Herzegovina: A cross-sectional study.

Acta Microbiol Immunol Hung 2022 Feb 14. Epub 2022 Feb 14.

1 University of Banja Luka, Faculty of Medicine, Centre for Biomedical Research, Banja Luka, The Republic of Srpska, Bosnia and Herzegovina.

Healthcare workers (HCW) in primary healthcare centres in the Republic of Srpska, Bosnia and Herzegovina, are on the first combat line with COVID-19. This study aimed to assess the seroprevalence of SARS-CoV-2 among HCW at the primary healthcare centres and to analyse the risk exposure to COVID-19, clinical signs and vaccination status. A cross-sectional study was conducted among HCW at the selected primary healthcare centres between 19 March and 30 April 2021. Read More

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February 2022

Mutation in mgrB is the major colistin resistance mechanism in Klebsiella pneumoniae clinical isolates in Tehran, Iran.

Acta Microbiol Immunol Hung 2022 Feb 3. Epub 2022 Feb 3.

1 Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Colistin is considered as one of a last resort antimicrobial agent against multidrug-resistant Gram-negative bacteria including Escherichia coli and Klebsiella pneumoniae. However, the recent emergence of colistin resistance (ColR) worldwide that severely restricts therapeutic options is a serious threat to global public health. In this study we have investigated the molecular determinants in ColR K. Read More

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February 2022

Investigation of multidrug-resistant Helicobacter pylori in pediatric patients: A Bulgarian study and literature data.

Acta Microbiol Immunol Hung 2022 Feb 2. Epub 2022 Feb 2.

1 Department of Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria.

Antibiotic resistance of Helicobacter pylori strains from 106 symptomatic children was evaluated according to EUCAST breakpoints and rate of multidrug resistance (MDR) was analyzed. Overall resistance rates were amoxicillin 7.5%, metronidazole 25. Read More

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February 2022

Changes in resistance pattern of ESKAPE pathogens between 2010 and 2020 in the clinical center of University of Szeged, Hungary.

Acta Microbiol Immunol Hung 2022 Jan 27. Epub 2022 Jan 27.

1 Department of Medical Microbiology, University of Szeged, Szeged, Hungary.

The acronym ESKAPE stands for six antibiotic-resistant bacterial pathogens namely, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. Monitoring their resistance is an important task for clinical microbiology laboratories. Our aim was to analyze the resistance patterns of these bacteria over ten years in clinical samples of our department. Read More

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January 2022

The role of microbiota and immune system crosstalk in cancer development and therapy.

Acta Microbiol Immunol Hung 2022 Jan 25. Epub 2022 Jan 25.

3 Department of Immunology, Pasteur Institute of Iran, Tehran, Iran.

Cancer is a multifactorial disease that is the second leading cause of death after cardiovascular disease in the world. In recent years, microbiota's role in the regulation and homeostasis of the immune system has been considered. Moreover, the immune system can affect the microbiota content. Read More

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January 2022

Detection of AmpC and ESBL-producing Enterobacterales isolated from urinary tract infections in Tunisia.

Acta Microbiol Immunol Hung 2022 Jan 17. Epub 2022 Jan 17.

1 Department of Life Sciences, Research Laboratory of Environmental Toxicology-Microbiology and Health (LR17ES06), Faculty of Sciences of Sfax, University of Sfax, Tunisia.

Urinary tract infections (UTIs) are the most frequent human infections in community and hospitals. This study aimed to determine the distribution of bacterial uropathogens among urinary tract infections diagnosed within the regional hospital Houcine Bouzaiene (Gafsa, South West Tunisia) during a survey of 54 days from the 8th of November to the 31st of December 2017. Enterobacterales strains were tested for antimicrobial resistance by disk diffusion method and extended-spectrum β-lactamase (ESBL) production was tested by double-disc synergy test. Read More

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January 2022

Multidrug resistant coagulase-negative Staphylococcus spp. isolated from cases of chronic rhinosinusitis in humans. Study from Poland.

Acta Microbiol Immunol Hung 2021 Dec 10. Epub 2021 Dec 10.

1 MML Medical Center, Bagno 2, 00-112, Warsaw, Poland.

For many years, coagulase-negative staphylococci (CoNS) have been considered non-pathogenic bacteria. However, recently, CoNS are becoming more common bacteriological factors isolated from cases of chronic rhinosinusitis in humans. Moreover, most of them represent the multidrug-resistant or/and methicillin-resistant profile, which significantly increases the therapeutic difficulties. Read More

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December 2021

Characterization of biofilm producing methicillin resistant coagulase negative Staphylococci from India.

Acta Microbiol Immunol Hung 2021 Dec 10. Epub 2021 Dec 10.

1 Department of Microbiology, Rajiv Gandhi Institute of Medical Sciences (RIMS), Government Medical College & Hospital, Kadapa, Andhra Pradesh, India.

Methicillin-resistant coagulase-negative staphylococci (MR-CoNS) cause infectious diseases due to their potential to form biofilm and further colonization in hospital materials. This study evaluated the antibiotic susceptible phenotypes, biofilm-producing ability, and biofilm-associated genes (mecA, icaAD, bap, cna, and fnbA). Biofilm formation was detected through Congo red agar (CRA) method and MTP method. Read More

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December 2021

Emergence of CC8/ST239- SCCmec III/t421 tigecycline resistant and CC/ST22-SCCmec IV/t790 vancomycin resistant Staphylococcus aureus strains isolated from wound: A two-year multi-center study in Tehran, Iran.

Acta Microbiol Immunol Hung 2021 Nov 22. Epub 2021 Nov 22.

4 Department of Critical Care and Anesthesiology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Staphylococcus aureus as an opportunistic bacterial pathogen with intrinsic and acquired resistance to many antibiotics is a worldwide problem. The current study was undertaken to evaluate the resistance pattern, and determine the genetic types of multidrug-resistant S. aureus isolated from wound. Read More

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November 2021

Common points of therapeutic intervention in COVID-19 and in allogeneic hematopoietic stem cell transplantation associated severe cytokine release syndrome.

Acta Microbiol Immunol Hung 2021 Nov 19. Epub 2021 Nov 19.

1Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Department of Hematology and Stem Cell Transplantation, Albert Florian ut 5-7, H-1097, Budapest, Hungary.

Allogeneic hematopoietic stem cell transplantation (HSCT) and coronavirus disease 2019 (COVID-19) infection can both lead to severe cytokine release syndrome (sCRS) resulting in critical illness and death. In this single institution, preliminary comparative case-series study we compared clinical and laboratory co-variates as well as response to tocilizumab (TCZ)-based therapy of 15 allogeneic-HSCT- and 17 COVID-19-associated sCRS patients. Reaction to a TCZ plus posttransplant cyclophosphamide (PTCY) consolidation therapy in the allogeneic-HSCT-associated sCRS group yielded significantly inferior long-term outcome as compared to TCZ-based therapy in the COVID-19-associated group (P = 0. Read More

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November 2021

Ceftazidime/avibactam resistance is associated with different mechanisms in KPC-producing Klebsiella pneumoniae strains.

Acta Microbiol Immunol Hung 2021 Nov 5. Epub 2021 Nov 5.

Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

This study focused on Klebsiella pneumoniae isolates that were resistant or had low susceptibility to a combination of ceftazidime/avibactam. We aimed to investigate the mechanisms underlying this resistance. A total of 24 multi-drug resistant isolates of K. Read More

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November 2021

Distribution of vaccine-related high-risk human papillomaviruses and their impact on the development of cervical dysplasia in women in Montenegro.

Acta Microbiol Immunol Hung 2021 Nov 1. Epub 2021 Nov 1.

1Institute of Public Health of Montenegro, Podgorica, Montenegro.

Cervical cancer (CC) is the third leading cause of death in women in Montenegro. Human papillomavirus (HPV) is the causative agent of CC however, HPV genotype distribution varies across regions. This study examined the distribution and impact of vaccine-related high-risk (HR)-HPVs on the development of cervical dysplasia in Montenegrin women. Read More

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November 2021

Prevalence of antimicrobial resistance in Campylobacter spp.: A review of the literature.

Acta Microbiol Immunol Hung 2021 Nov 1. Epub 2021 Nov 1.

3Faculty of Stomatology, Pančevo, University Busines Academy in Novi Sad, Serbia.

Campylobacter spp. are commensal organisms in the intestinal tract of food producing and companion animals. There is an increasing trend of human campylobacteriosis worldwide, including complicated cases that request treatment by antibiotics. Read More

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November 2021

Detection of extensively drug-resistant and hypervirulent Klebsiella pneumoniae ST15, ST147, ST377 and ST442 in Iran.

Acta Microbiol Immunol Hung 2021 Sep 20. Epub 2021 Sep 20.

1 Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In this study, we focused on the emergence of extensively drug-resistant (XDR), pandrug-resistant (PDR), and hypervirulent Klebsiella pneumoniae (hvKP) in Iran. During 2018 to 2020 a total of 52 K. pneumoniae isolates were collected from different clinical specimens. Read More

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September 2021

Prevalence of trimethoprim/sulfamethoxazole resistance genes among Stenotrophomonas maltophilia clinical isolates in Egypt.

Acta Microbiol Immunol Hung 2021 Sep 20. Epub 2021 Sep 20.

Department of Microbiology, Medical Research Institute, Alexandria University, Alexandria, 21561, Egypt.

Stenotrophomonas maltophilia is an important multidrug resistant nosocomial pathogen. Trimethoprim/sulfamethoxazole (TMP/SMX) is considered the drug of choice for treatment of S. maltophilia infections, thus emerging resistance to TMP/SMX poses a serious threat. Read More

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September 2021

Association between biofilm-production and antibiotic resistance in Escherichia coli isolates: A laboratory-based case study and a literature review.

Acta Microbiol Immunol Hung 2021 Sep 14. Epub 2021 Sep 14.

6Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Semmelweis utca 6., 6725 Szeged, Hungary.

Bacteria can enhance their survival by attaching to inanimate surfaces or tissues, and presenting as multicellular communities encased in a protective extracellular matrix called biofilm. There has been pronounced interest in assessing the relationship between the antibiotic resistant phenotype and biofilm-production in clinically-relevant pathogens. The aim of the present paper was to provide additional experimental results on the topic, testing the biofilm-forming capacity of Escherichia coli isolates using in vitro methods in the context of their antibiotic resistance in the form of a laboratory case study, in addition to provide a comprehensive review of the subject. Read More

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September 2021

Fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with concurrent ulcerative colitis.

Acta Microbiol Immunol Hung 2021 Aug 6. Epub 2021 Aug 6.

3Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Treatment of recurrent Clostridioides difficile infection (rCDI) has emerged as an important management dilemma particularly in patients with underlying inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been used as a safe and highly effective treatment option for rCDI refractory to standard antibiotic therapies. The aim of this study was to report the efficacy of FMT in Iranian rCDI patients with concurrent IBD. Read More

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Prevalence and antifungal drug resistance of dermatophytes in the clinical samples from Pakistan.

Acta Microbiol Immunol Hung 2021 Aug 11. Epub 2021 Aug 11.

1Department of Microbiology, Kohat University of Science & Technology (KUST), Kohat, Khyber Pakhtunkhwa, Pakistan.

Dermatophytosis is a major health problem all over the world including Pakistan. This is the first report of detection of dermatophytes and their antifungal drug resistance in the Northern and Western parts of Pakistan. A total of 154 samples were collected from different hospitals of Khyber Pakhtunkhwa, and out of them 136 samples were found positive. Read More

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Alpha variant (B.1.1.7) of SARS-CoV-2 increases fatality-rate for patients under age of 70 years and hospitalization risk overall.

Acta Microbiol Immunol Hung 2021 Aug 11. Epub 2021 Aug 11.

7The Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

The emergence of new SARS-CoV-2 variants is a challenge to the control of this pandemic. It is therefore important to collect and to analyze data related to the infection caused by different variants. We have obtained more than 3,700 COVID-19 patients between April 2020 and March 2021 from Tokat, Turkey (roughly 3,100 outpatients and close to 600 inpatients) where about 30% were infected with Alpha variant (B. Read More

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