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Acta Microbiol Immunol Hung 2019 Mar 5:1-10. Epub 2019 Mar 5.

3 Department of Parasitology, Faculty of Medicine, Ilam University of Medical Sciences , Ilam, Iran.

In recent years, increasing dust phenomenon in the west of Iran has led to social, economic, and health concerns. This study aimed to represent the existence and genotyping of Acanthamoeba spp. in dust phenomenon in Ilam Province, Iran. Read More

Acta Microbiol Immunol Hung 2019 Mar 5:1-12. Epub 2019 Mar 5.

2 Department of Ophthalmology, Semmelweis University , Budapest, Hungary.

Genus Acanthamoeba is an opportunistic protozoan that is widely distributed in the environment. Within this genus, numerous species are recognized as human pathogens, potentially causing Acanthamoeba keratitis (AK). AK is a corneal disease, associated predominantly with contact lens (CL) wear; its epidemiology is related to the specific Acanthamoeba genotypes. Read More

Acta Microbiol Immunol Hung 2019 Mar 28;66(1):113-130. Epub 2019 Feb 28.

1 Department of Environmental Safety and Ecotoxicology, Szent István University , Gödöllő, Hungary.

The emergence of opportunistic Acinetobacter spp. in healthcare settings poses a significant threat to public health. The major reasons for nosocomial spread of these species are their abilities to develop and transfer drug resistance against various classes of antibiotics. Read More

Acta Microbiol Immunol Hung 2019 Mar 28;66(1):31-55. Epub 2019 Feb 28.

1 Faculty of Tropical Medicine, Department of Microbiology and Immunology Mahidol University , Bangkok, Thailand.

Murine models are suggested as the gold standard for scientific research, but they have many limitations of ethical and logistical concern. Then, the alternative host models have been developed to use in many aspects especially in invertebrate animals. These models are selected for many areas of research including genetics, physiology, biochemistry, evolution, disease, neurobiology, and behavior. Read More

Acta Microbiol Immunol Hung 2019 Feb 26:1-9. Epub 2019 Feb 26.

4 Clinical Unit of Microbiology, Department of Microbiology, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba , Córdoba, Spain.

Escherichia coli and Klebsiella pneumoniae are frequently found resistance to aminoglycosides in Turkey. The aim of this study was to investigate aminoglycoside resistance in clinical isolates of E. coli and K. Read More

Acta Microbiol Immunol Hung 2019 Feb 26:1-15. Epub 2019 Feb 26.

1 Department of Genetics, Cell- and Immunobiology, Semmelweis University , Budapest, Hungary.

Ah-receptors (AhRs) recognize and bind foreign environmental molecules as well as some target hormones of other nuclear receptors. As ligands activate transcription factors, they transmit the information on the presence of these molecules by binding to the DNA, which in turn activate xenobiotic metabolism genes. Cross talk with other nuclear receptors or some non-nuclear receptors also activates or inhibits endocrine processes. Read More

Acta Microbiol Immunol Hung 2019 Feb 26:1-12. Epub 2019 Feb 26.

3 Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University , Artvin, Turkey.

A carbapenem-resistant Klebsiella pneumoniae strain was isolated in Turkey in 2012 and bla and bla genes were observed in this strain. The aim of this study was to investigate transferability of plasmid bearing bla in K. pneumoniae and to use whole-genome sequencing in order to understand the genetic context of plasmid. Read More

Acta Microbiol Immunol Hung 2019 Feb 26:1-18. Epub 2019 Feb 26.

1 Department of Molecular Biology, Pasteur Institute of Iran , Tehran, Iran.

Klebsiella pneumoniae is among the most important causes of urinary tract infection (UTI). The aim of this study was to investigate the prevalence and correlation of antibiotic resistance with virulence characteristics and genetic diversity in K. pneumoniae isolated from UTIs in Iran. Read More

Acta Microbiol Immunol Hung 2019 Feb 21:1-12. Epub 2019 Feb 21.

2 Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran.

The emergence of 16S rRNA methylase genes encoded on plasmids confers high-level aminoglycoside resistance (HLAR). This study aimed to investigate the prevalence of 16S rRNA methylases among Enterobacter cloacae strains isolated from an Ahvaz teaching hospital, Iran. A total of 68 E. Read More

Acta Microbiol Immunol Hung 2019 Feb 21:1-19. Epub 2019 Feb 21.

1 Faculty of Medicine, University of Belgrade , Belgrade, Serbia.

We investigated the incidence of bloodstream infections (BSIs) in trauma emergency department (ED) and intensive care unit (ICU), to assess ED- and ICU-related predictors of BSI and to describe the most common bacteria causing BSI and their antimicrobial resistance markers. A prospective study was conducted in two trauma ICUs of the ED of Clinical Center of Serbia. Overall, 62 BSIs were diagnosed in 406 patients, of which 13 were catheter-related BSI (3. Read More

Acta Microbiol Immunol Hung 2019 Jan 25:1-12. Epub 2019 Jan 25.

2 Centre for Medical Microbiology, National Laboratory for Health, Environment and Food , Maribor, Slovenia.

The methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes of a variety of infections in hospitals and the community. One of the most prominent changes in the MRSA epidemiology is the emergence of livestock-associated MRSA (LA-MRSA) strains in the human population. The aim of this study was to follow the MRSA epidemiology in a large teaching hospital during an 8-year time period (2006-2013). Read More

Acta Microbiol Immunol Hung 2018 Dec 26:1-10. Epub 2018 Dec 26.

1 Department of Infectology, 1st Department of Internal Medicine, University of Pécs , Pécs, Hungary.

Dramatic changes in the epidemiology of Clostridium difficile infections have been reported from the western world in the past decade. The proportion of severe cases is significantly elevating and clinicians now have to contend with the problem of additional and more frequent episodes of recurrences including an upward trend in the mortality rate. This situation led us to investigate the possibility of the fecal microbiota transplantation (FMT). Read More

Acta Microbiol Immunol Hung 2018 Dec 26:1-6. Epub 2018 Dec 26.

1 Department of Medical Microbiology, Medical University of Sofia , Sofia, Bulgaria.

Helicobacter pylori positivity was assessed among 656 symptomatic children in 2010-2017. Overall infection prevalence was 24.5% and a significantly higher rate was detected in girls (28. Read More

Acta Microbiol Immunol Hung 2018 Dec;65(4):419-420

1 Professor, Editor-in-Chief of AMIH Doctor of the Hungarian Academy of Sciences Director of the Institute of Medical Microbiology Semmelweis University , Budapest.

Acta Microbiol Immunol Hung 2018 Nov 28:1-16. Epub 2018 Nov 28.

3 Faculty of Agriculture, Department of Agricultural Biotechnology, Ondokuz Mayis University , Samsun, Turkey.

Immunogenic potency of the recombinant Erp, HspR, LppX, MmaA4, and OmpA proteins from Mycobacterium tuberculosis (MTB), formulated with Montanide ISA 720 VG adjuvant, was evaluated in BALB/c mice for the first time in this study. The five vaccine formulations, adjuvant, and BCG vaccine were subcutaneously injected into mice, and the sera were collected at days 0, 15, 30, 41, and 66. The humoral and cellular immune responses against vaccine formulations were determined by measuring serum IgG and serum interferon-gamma (IFN-γ) and interleukin-12 (IL-12) levels, respectively. Read More

Acta Microbiol Immunol Hung 2018 Nov 22:1-8. Epub 2018 Nov 22.

1 Laboratory of Molecular Biology and Biotechnology, Blokhina Scientific Research Institute of Epidemiology and Microbiology of Nizhny Novgorod , Nizhny Novgorod, Russian Federation.

Transforming growth factor β 1 (TGFB1) likely contributes to the pathogenesis of Epstein-Barr virus (EBV)-mediated cancer. A microarray containing 59 probes for detecting mRNA of members of TGFB1-associated pathways was developed. mRNA expression of TGFB1 receptors and members of connected pathways were examined in peripheral blood leukocytes of patients during acute EBV infection and after recovery. Read More

Acta Microbiol Immunol Hung 2018 Nov 22:1-15. Epub 2018 Nov 22.

1 Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences , Shiraz, Iran.

Multiple drug-resistant enterococci are major cause of healthcare-associated infections due to their antibiotic resistance traits. Among them, Enterococcus faecalis is an important opportunistic pathogen causing various hospital-acquired infections. A total of 53 E. Read More

Acta Microbiol Immunol Hung 2018 Nov 22:1-10. Epub 2018 Nov 22.

1 Institute of Medical Microbiology, Semmelweis University , Budapest, Hungary.

Fluoroquinolone resistance in Enterobacteriales is developed by chromosomal and plasmid-mediated mechanisms. Plasmids play an important role in dissemination of resistant genes and they carry genes that protect bacteria in different stress-induced situations. In this study, we studied Escherichia coli strains, each carried one plasmid-mediated quinolone resistance determinant namely, qnrA1, qnrB1, qnrC1, and qnrD1. Read More

Acta Microbiol Immunol Hung 2018 Dec 12;65(4):551-564. Epub 2018 Nov 12.

1 Clinic of Children's Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius, Lithuania.

Nutritional iron deficiency (ID) causes not only anemia but also malfunction of the entire human organism. Recently, a role of the gut microbiota has been hypothesized, but limited data are available especially in infants. Here, we performed a pilot study to explore the gut microbiota in 10 patients with iron deficiency anemia (IDA) and 10 healthy controls aged 6-34 months. Read More

Acta Microbiol Immunol Hung 2019 Mar 7;66(1):143-154. Epub 2018 Nov 7.

1 Department of Public Health and Psychiatry, Malaga University , Malaga, Spain.

The success of Acinetobacter baumannii as an emerging organism is probably linked to its high resistance to adverse environmental conditions. This study was conducted to analyze the association between some factors that may favor the dissemination of A. baumannii clinical isolates. Read More

Acta Microbiol Immunol Hung 2019 Mar 7;66(1):103-112. Epub 2018 Nov 7.

3 Department of Clinical Microbiology, Ankara Training and Research Hospital , Ankara, Turkey.

When the problem with carbapenem-resistant Enterobacteriaceae (CRE) increases, the older antimicrobial agents such as colistin and fosfomycin are used for the treatment of these infections. In this study, the broth microdilution method for colistin and the agar dilution method for fosfomycin were used for a total of 147 multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains of CRE. The study included Klebsiella pneumoniae (91. Read More

Acta Microbiol Immunol Hung 2019 Mar 7;66(1):131-142. Epub 2018 Nov 7.

1 Department of Microbiology, Medical Research Institute, Alexandria University , Alexandria, Egypt.

Thirty-three Pseudomonas aeruginosa isolates, resistant to one or more β-lactams, were included in this study. Identification of tested strains was confirmed using MALDI-TOF/MS. Phenotypic and genotypic β-lactamase patterns were investigated. Read More

Acta Microbiol Immunol Hung 2019 Mar 24;66(1):57-68. Epub 2018 Sep 24.

4 School of Medicine, Shahroud University of Medical Sciences , Shahroud, Iran.

Enterococcus faecalis is one of the most significant pathogen in both nosocomial and community-acquired infections. Reduced susceptibility to antibiotics is in part due to efflux pumps. This study was conducted on 80 isolates of E. Read More

Acta Microbiol Immunol Hung 2019 Mar 11;66(1):79-89. Epub 2018 Sep 11.

2 Infection Disease Clinic, Tokat State Hospital , Tokat, Turkey.

The Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne virus, whose viral RNA consists of S, L, and M segments. The virus is migrating through the ticks with animals and migratory birds and the geographical distribution can be investigated based on genetic analysis. To better understand the connection between the seropositivity and the mortality rate, the key factor could be the temporal and spatial analysis of the different strains. Read More

Acta Microbiol Immunol Hung 2018 Dec 11;65(4):467-476. Epub 2018 Sep 11.

1 Faculty of Tropical AgriSciences, Department of Crop Sciences and Agroforestry, Czech University of Life Sciences Prague , Prague, Czech Republic.

Staphylococcus aureus is a major human pathogen that is responsible for both hospital- and community-acquired infections. Stilbenes are polyphenol compounds of plant origin known to possess a variety of pharmacological properties, such as antibacterial, antiviral, and antifungal effects. This study reports the in vitro growth-inhibitory potential of eight naturally occurring stilbenes against six standard strains and two clinical isolates of S. Read More

Acta Microbiol Immunol Hung 2019 Mar 11;66(1):91-101. Epub 2018 Sep 11.

4 Department of Laboratory Sciences, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran.

Shigella spp. are a major cause of bacillary dysentery, particularly among children in developing countries such as Iran. This study aimed to investigate the presence of two important Shigella enterotoxins (ShET-1 and ShET-2), encoded by the set and sen genes, respectively, by polymerase chain reaction (PCR) assay among Shigella species isolated from children affected by shigellosis in Ahvaz, southwest of Iran. Read More

Acta Microbiol Immunol Hung 2018 Dec 16;65(4):529-538. Epub 2018 Aug 16.

1 Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences , Isfahan, Iran.

The objective of this study was to assess the prevalence, antibiogram, and related genes of carbapenem-resistant Klebsiella pneumoniae (CRKP) among hospital environment samples. A total of 250 samples were taken from different surfaces and medical devices of three hospitals in Isfahan, Iran. All samples were cultured and K. Read More

Acta Microbiol Immunol Hung 2018 Dec 16;65(4):539-550. Epub 2018 Aug 16.

3 Department of Human Genetics, Centre for Cellular and Molecular Biology , Hyderabad, India.

Carbapenems are administered as the final drug of choice for treating complicated nosocomial infections caused by multidrug-resistant Acinetobacter baumannii strains. It is currently a worldwide issue that metallo-β-lactamases (MBLs) as carbapenem-hydrolyzing enzymes are one of the major drug resistance mechanisms. This investigation is thus aimed to assess the prevalence and characterize the MBL-producing strains of A. Read More

Acta Microbiol Immunol Hung 2018 Aug 25;65(3):387-403. Epub 2018 Jul 25.

3 Division of Bacteriology, Mycology, Parasitology and Typing, National Public Health Institute , Budapest, Hungary.

Silver is used extensively in both hospitals and outpatient clinics as a disinfectant coating agent on various devices. Resistance to silver was recently reported as an emerging problem in Enterobacteriaceae. Multidrug-resistant high-risk clones of Klebsiella pneumoniae are common causes of serious healthcare-associated infections worldwide posing a serious threat to patients. Read More

Acta Microbiol Immunol Hung 2018 Dec 19;65(4):489-499. Epub 2018 Jul 19.

3 Faculty of Medicine, Department of Anatomy, Lorestan University of Medical Sciences , Khorramabad, Iran.

The proinflammatory cytokines of TNF-α and IL-1β have been reported to be increased in gastric mucosal surfaces in people with Helicobacter pylori infection. Accordingly, this study was conducted to investigate the relationship between the presence of H. pylori genes and the serum oscillations of these cytokines. Read More

Acta Microbiol Immunol Hung 2018 Aug 19;65(3):335-344. Epub 2018 Jul 19.

1 Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences , Isfahan, Iran.

The aim of this study was to investigate the prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) and the most common types of carbapenemases, metallo-beta-lactamases (MBLs), and extended-spectrum beta-lactamases (ESBLs) among CRKP isolates in a tertiary hospital in Isfahan, Iran. Eighty non-repetitive clinical isolates of K. pneumoniae were obtained from different clinical specimens. Read More

Acta Microbiol Immunol Hung 2018 Aug 19;65(3):405-418. Epub 2018 Jul 19.

1 Department of Immunology, State Research Institute, Centre for Innovative Medicine , Vilnius, Lithuania.

The aim of this study was to determine the effect of mycobacterial proteins on mycobacterial biofilm formation and growth processes. We separated growth-affecting proteins (GEPs) from wild type of Mycobacterium bovis and ATCC strain of Mycobacterium avium subsp. avium. Read More

Acta Microbiol Immunol Hung 2018 Jul 17:1-14. Epub 2018 Jul 17.

1 Department of Genetics, Cell- and Immunobiology, Semmelweis University , Budapest, Hungary.

The hormesis concept demonstrates that in contrast to the toxic effect of high doses of materials, irradiation, etc., low doses of them are beneficial and, in addition, help to eliminate (prevent) the deleterious effect of high doses given after it. By this effect, it is an important factor of (human) evolution protecting man from harmful impacts, similarly to the role of immunity. Read More

Acta Microbiol Immunol Hung 2019 Mar 16;66(1):19-30. Epub 2018 Jul 16.

2 Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences , Tehran, Iran.

The pan-genomic microarray technique is used for environmental and/or clinical studies. Although microarray is an accurate and sharp diagnostic tool, the expertized bioinformaticians were able to minimize the outcome biases and maximize the flexibility and accuracy of the technique. The knowledge of bioinformatics plays a key role in association with probe designing and the utilization of correct probe sets and platforms. Read More

Acta Microbiol Immunol Hung 2018 Dec 16;65(4):477-488. Epub 2018 Jul 16.

1 Institute of Microbiology and Immunology, Medical Faculty University of Belgrade , Belgrade, Republic of Serbia.

Numerous reports have confirmed that increased macrolide use in the treatment of respiratory tract infection has contributed to the emergence of antibiotic resistance worldwide. Studies have also shown that pneumococcal vaccine can reduce pneumococcal resistance. The aim of this study was to determine the prevalence of co-resistance to penicillin and other antibiotics in macrolide-resistant (MR) non-invasive pneumococcal isolates and to evaluate serotype distribution in resistant strains in the pre-vaccine era in Serbia. Read More

Acta Microbiol Immunol Hung 2018 Dec 16;65(4):515-527. Epub 2018 Jul 16.

1 Department of Medical Microbiology, Dokuz Eylul University , İzmir, Turkey.

The typing of non-tuberculous mycobacteria (NTM) is important from a clinical and epidemiological perspective. The polymerase chain reaction-restriction enzyme analysis (PRA) method and DNA sequence analysis method were utilized to target a gene region that codes the 65-kDa heat-shock protein for typing 150 suspected NTM samples isolated from the respiratory tract. Mycobacterium abscessus, Mycobacterium xenopi, Mycobacterium fortuitum, and Mycobacterium peregrinum were most frequently found by both methods. Read More

Acta Microbiol Immunol Hung 2018 Dec 16;65(4):501-513. Epub 2018 Jul 16.

1 CIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon , Lisbon, Portugal.

Dissemination of pathogenic multiresistant bacteria is of public health concern. Reliable data can be difficult to obtain, especially in developing countries. This work aimed to characterize the skin and oropharyngeal microbiota, as well as their antimicrobial resistance profiles, of East-Timor populations to identify potentially pathogenic Gram-positive cocci. Read More

Acta Microbiol Immunol Hung 2019 Mar 3;66(1):1-17. Epub 2018 Jul 3.

1 Department of Genetics, Cell- and Immunobiology, Semmelweis University , Budapest, Hungary.

The role of immune system is to protect the organism from the not built-in program-like alterations inside and against the agents penetrating from outside (bacteria, viruses, and protozoa). These functions were developed and formed during the evolution. Considering these functions, the immune system promotes the lengthening of lifespan and helps longevity. Read More

Acta Microbiol Immunol Hung 2018 Jun 24;65(2):163-171. Epub 2018 Apr 24.

4 Department of Nuclear Sciences and Applications, Animal Production and Health Section, International Atomic Energy Agency (IAEA), VIC , Vienna, Austria.

Avian influenza (AI) A subtype H9N2 virus belongs to Orthomyxoviridae family and causes low-pathogenic disease AI. The use of gamma-irradiated viral antigens has been developed in the production of effective vaccines. In this research, LPAIV H9N2 strain, A/Chicken/IRN/Ghazvin/2001, was multiplied on SPF eggs and irradiated by a Nordian gamma cell instrument. Read More

Acta Microbiol Immunol Hung 2018 Jun 24;65(2):229-240. Epub 2018 Apr 24.

2 Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade , Belgrade, Serbia.

In this study, the focus was on the effects of sub-MICs of the antibiotics on adherence, hydrophobicity, and biofilm formation by two groups of Streptococcus pyogenes strains, which were responsible for different clinical cases. The aim of this study was to explore the effects of sub-MICs of penicillin, ceftriaxone, erythromycin, and clindamycin on adherence, surface hydrophobicity, and biofilm biomass in two selected collections of group A streptococcus (GAS): strains isolated from carriers (CA) and strains isolated from patients with tonsillopharyngitis (TPh). Isolates were tested for hydrophobicity to xylene, adherence, and biofilm production in uncoated microtiter plates before and after treatment with 1/2 and 1/4 MICs of antibiotics. Read More

Acta Microbiol Immunol Hung 2018 Aug 13;65(3):317-323. Epub 2018 Apr 13.

4 Faculty of Medicine, Institute of Clinical Microbiology, University of Szeged , Szeged, Hungary.

An imipenem-resistant Bacteroides fragilis strain was isolated from the blood of a 72-year-old male patient with a urinary bladder tumor in Osijek, Croatia. This strain was also resistant to ampicillin, piperacillin/tazobactam, cefoxitin, clindamycin, tetracycline, and harbored cfiA, ermF, and tetQ genes where the high-level expression of the cfiA carbapenem-resistant gene was driven by an IS1187 element. Interestingly, despite the carbapenem-resistant feature of the B. Read More

Acta Microbiol Immunol Hung 2018 Jun 13;65(2):183-192. Epub 2018 Apr 13.

1 First Department of Internal Medicine, Institute of Infectious Diseases, University of Pécs , Pécs, Hungary.

In the past decade, Clostridium difficile infections (CDIs) have become a major public health challenge. Their epidemiology has radically changed with a significant rise in the number of cases and an increase in severe episodes. Recurrence and failure of conventional treatments are very common. Read More

Acta Microbiol Immunol Hung 2018 Aug 13;65(3):325-333. Epub 2018 Apr 13.

1 Faculty of Engineering and Natural Sciences, Department of Genetics and Bioengineering, Gümüşhane University , Gümüşhane, Turkey.

The aim of this work was investigation of clinically important amino acid substitutions of NDM-1 variants. A bla gene was cloned into expression vector pET100/D-TOPO. The sequence of NDM-1 variants with substituted amino acids was determined by ClustalW program. Read More

Acta Microbiol Immunol Hung 2018 Jun 19;65(2):193-209. Epub 2018 Mar 19.

1 Department of Microbiology, School of Medicine, Tehran University of Medical Sciences , Tehran, Iran.

One third of the world population are latently infected with Mycobacterium tuberculosis and are at the risk of reactivation of tuberculosis (TB). The most effective strategy for control of TB worldwide is the development of a vaccine that inhibits progression of latent TB to active infection. In this study, two optimized constructs consisting of multi-epitopes DNA derived from three latency antigens Rv2029c, Rv2031c, and Rv2627c fused with or without light chain 3 (LC3) are synthetized. Read More

Acta Microbiol Immunol Hung 2018 Aug 19;65(3):267-307. Epub 2018 Mar 19.

1 Department of Biotechnology and Microbiology, University of Debrecen , Debrecen, Hungary.

Fungal toxins are secondary metabolites, in which many of them were mycotoxins, affecting eukaryotic cells with a broad range of structural and functional variety contributing to the multitude of their classification. This refers to the harmful genotoxic (mutagenic, teratogenic, and carcinogenic) effects of mycotoxins on the one hand, and their cytocidic and antineoplastic properties on the other hand. This "double edged sword" effect could be utilized against the spread of tumors in older patients when the survival is much more important than the mutagenic side effects. Read More

Acta Microbiol Immunol Hung 2018 Dec 19;65(4):459-465. Epub 2018 Mar 19.

2 Department of Gynecology and Obstetrics, Jahn Ferenc South Pest Hospital , Budapest, Hungary.

Enterobiasis is an easily recognizable and treatable disease with higher incidence among children. Based on these facts, its clinical importance is usually underestimated. This infection also occurs during adulthood and without treatment, it can cause severe complications in some rare cases. Read More

Acta Microbiol Immunol Hung 2018 Aug 7;65(3):309-315. Epub 2018 Mar 7.

1 Institute of Medical Microbiology, Jena University Hospital , Jena, Germany.

There is a need for easy-to-use molecular assays for diagnosis of invasive meningococcal disease. Here, we report the rapid identification of Neisseria meningitidis in a cerebrospinal fluid sample from a patient with purulent meningitis using a commercially available loop-mediated isothermal amplification assay, resulting in a prompt de-escalation of the initial empiric antibiotic therapy. Read More

Acta Microbiol Immunol Hung 2018 Jun 7;65(2):119-125. Epub 2018 Mar 7.

1 Department of Medical Sciences, Section of Microbiology, University of Ferrara , Ferrara, Italy.

Human herpesvirus 6 (HHV-6) comprises two viral species, HHV-6A and HHV-6B, closely related but differing for pathogenic and biological characteristics. Both viral species are predominantly lymphotropic, infecting T lymphocytes and other lymphoid cells, including natural killer (NK) cells. The interactions between HHV-6 and NK cells have been scarcely studied, but it has become clear that NK cells are not only crucial in immune protection during the early phases of infection, but also that HHV-6 infection can affect NK cell functions. Read More

Acta Microbiol Immunol Hung 2018 Mar 28;65(1):1-14. Epub 2018 Feb 28.

1 Department of Genetics, Cell- and Immunobiology, Semmelweis University , Budapest, Hungary.

Endocrine disruptors (EDs) are bound by steroid receptors, have steroid-like effects, and by this, negatively influence hormone-regulated processes. Phytoestrogens, which are consumed in enormously high amount by man, are also EDs; however, in contrast to industrial or communal EDs, in some cases have beneficial effects. As immune cells have steroid (first of all, estrogen) nuclear and plasma membrane receptors, which bind phytostrogens (genistein, daidzein, etc. Read More

Acta Microbiol Immunol Hung 2018 Dec 28;65(4):421-438. Epub 2018 Feb 28.

1 Department of Medical Microbiology and Immunology, Medical School, University of Pecs , Pecs, Hungary.

Incidence of type 1 diabetes (T1D) is on the rise and yet, despite decades of research, the exact ethology of the disease still remains a mystery. The autoimmune reaction, which ultimately leads to the destruction of pancreatic beta cells, causing insulin deficiency and T1D, is a result of genetic susceptibility and environmental factors. Precisely, what are these environmental factors? Current popular opinion implies these pathogens, such as viruses, especially human enteroviruses, are a triggering factor. Read More