655,673 results match your criteria Acta Metallurgica Sinica-english Letters[Journal]


Rationally introduce AIE into chemosensor: A novel and efficient way to achieving ultrasensitive multi-guest sensing.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 10;218:263-270. Epub 2019 Apr 10.

Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education of China; Research Center of Gansu Military and Civilian Integration Advanced Structural Materials; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu, 730070, China.

Recently, ultrasensitive detection and multi-guest sensing have received extensive attention due to their high sensitivity and efficiency. Herein, we report a novel approach to achieve ultrasensitive detection of multi-analyte. This approach is concluded as "rationally introduce Aggregation-Induced Emission (AIE) into chemosensor". Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.014DOI Listing

Synthesis, molecular properties and comparative docking and QSAR of new 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid derivatives as possible anticancer agents.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 7;218:248-262. Epub 2019 Apr 7.

Chemistry Department, Faculty of Science, Al-Azhar University (Boys Branch), Nasr City, Cairo, Egypt.

Novel coumarin amino acid derivatives were synthesized. The structure of synthesized compounds has established on basis of different spectral data. The optimization geometry, frontier molecular orbitals (FMOs), thermodynamic parameters and chemical reactivity, were discussed using DFT\B3LYP by 6-311G* basis set, to identify a clear view for inter and intramolecular interaction of tested compounds. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193019
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http://dx.doi.org/10.1016/j.saa.2019.02.074DOI Listing
April 2019
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Fourier transform infrared spectroscopy research on subchondral bone in osteoarthritis.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 11;218:243-247. Epub 2019 Apr 11.

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China. Electronic address:

Osteoarthritis (OA) is not only related to the degradation of articular cartilage, but also possibly to the changes of subchondral bone. The purpose of this study was to assess whether specific differences could be resolved from bone composition, as also contributed to OA. These differences were assessed by using Fourier transform infrared spectroscopy (FTIRS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193039
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http://dx.doi.org/10.1016/j.saa.2019.04.020DOI Listing
April 2019
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Reevaluating the effects of reorganization energy on electron transfer rate for quantum dot-molecular acceptor complexes in different solvents.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 11;218:237-242. Epub 2019 Apr 11.

Institute of Atomic and Molecular Physics, Jilin University, Changchun 130012, China. Electronic address:

The electron transfer (ET) rate in quantum dot (QD)-molecular acceptor systems is dependent upon system reorganization energy (RE, λ), which comprises contributions from solvent (λ) and reactants (λ). However, to date, the effect of λ on ET rate has been largely ignored. Herein, the ET from CdSe/ZnS QDs to 1-chloroanthraquinone (1-CAQ) in different solvents was investigated using ultrafast transient absorption spectroscopy as a means to evaluate the effect of λ on ET rate. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.016DOI Listing

Inhibition of copper-induced aggregation of human γD-crystallin by rutin and studies on its role in molecular level for enhancing the chaperone activity of human αA-crystallin by using multi-spectroscopic techniques.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 10;218:229-236. Epub 2019 Apr 10.

Department of Chemistry, National Institute of Technology Hamirpur, Himachal Pradesh 177005, India. Electronic address:

Oxidative aggregation of γ-crystallins induced by copper in aged lens increases the lens opacity and causes cataract formation. Therefore, chelation of free Cu by small molecules can inhibit metal-mediated aggregation of γ-crystallin. In this work, the inhibition potency of several naturally occurring flavonoid compounds was studied against aggregation of human γD-crystallin (HGD) mediated by copper ions. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.013DOI Listing

3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address:

Chitosan (Ch) is used in different biomedical applications to promote tissue repair. However, tissue injury caused by biomaterial implantation lead to the release of danger signals that engage different inflammatory pathways on the host. Different implanted materials activate the inflammasome leading to the modulation of the immune response. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193027
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http://dx.doi.org/10.1016/j.actbio.2019.04.035DOI Listing
April 2019
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Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8 T cells.

Acta Biomater 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands. Electronic address:

Outer membrane vesicles (OMVs) are vesicular nano-particles produced by Gram-negative bacteria that are recently being explored as vaccine vector. The fact that OMVs can be efficiently produced by a hypervesiculating Salmonella typhimurium strain, are packed with naturally-occurring adjuvants like lipopolysaccharides (LPS), and can be engineered to express any antigen of choice, makes them ideal candidates for vaccinology. However, it is unclear whether OMVs induce dendritic cell (DC)-mediated antigen-specific T cell responses and how immune activation is coordinated. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.033DOI Listing

The frequency of referent objects influences expectations about label length.

Authors:
Tibor Tauzin

Acta Psychol (Amst) 2019 Apr 16;196:70-74. Epub 2019 Apr 16.

Cognitive Science Department, Central European University, Október 6. u. 7, H-1051 Budapest, Hungary. Electronic address:

Earlier studies suggest that word length is influenced by the linguistic context to be precise and concise at the same time. The present study investigates whether the referential-situational context can also have an effect on the expected length of words. To test this assumption a salient property of the situational context, that is, the frequency of the unfamiliar referents was varied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00016918183049
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http://dx.doi.org/10.1016/j.actpsy.2019.04.010DOI Listing
April 2019
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Temporal integration and attentional selection of color and contrast target pairs in rapid serial visual presentation.

Acta Psychol (Amst) 2019 Apr 16;196:56-69. Epub 2019 Apr 16.

University of Groningen, the Netherlands.

Performance in a dual target rapid serial visual presentation task was investigated, dependent on whether the color or the contrast of the targets was the same or different. Both identification accuracy on the second target, as a measure of temporal attention, and the frequency of temporal integration were measured. When targets had a different color (red or blue), overall identification accuracy of the second target and identification accuracy of the second target at Lag 1 were both higher than when targets had the same color. Read More

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http://dx.doi.org/10.1016/j.actpsy.2019.04.002DOI Listing

SMP domain proteins in membrane lipid dynamics.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore; Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan. Electronic address:

Synaptotagmin-like mitochondrial-lipid-binding (SMP) domain proteins are evolutionarily conserved family of proteins in eukaryotes that localize between the endoplasmic reticulum (ER) and either plasma membrane (PM) or other organelles. They are involved in tethering of these membrane contact sites through interaction with other proteins and membrane lipids. Recent structural and biochemical studies have demonstrated that SMP domain proteins transport a wide variety of lipid species by the ability of the SMP domain to harbor lipids through its unique hydrophobic cavity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13881981193005
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http://dx.doi.org/10.1016/j.bbalip.2019.04.007DOI Listing
April 2019
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The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Biology, Barnard College-Columbia University, New York, NY 10027, United States of America. Electronic address:

Niemann-Pick type C (NP-C) disease is a rare and fatal neurodegenerative disease typified by aberrations in intracellular lipid transport. Cholesterol and other lipids accumulate in the late endosome/lysosome of all diseased cells thereby causing neuronal and visceral atrophy. A cure for NP-C remains elusive despite the extensive molecular advances emanating from the identification of the primary genetic defect in 1997. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.002DOI Listing
April 2019
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Lung cancer-derived extracellular vesicles induced myotube atrophy and adipocyte lipolysis via the extracellular IL-6-mediated STAT3 pathway.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathogenic Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. Electronic address:

Cancer-associated cachexia (CAC) constitutes a metabolic dysfunction characterized by systemic inflammation and body weight loss. Muscle atrophy and adipose tissue lipolysis might explain weight loss in CAC. Specific functions of numerous hormones and cytokines derived from tumours can provoke cachexia. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.006DOI Listing

Compromising human skin in vivo and ex vivo to study skin barrier repair.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address:

Ex vivo regenerated stratum corneum (SC) after tape-stripping can be used as a model to study the barrier function of compromised skin. Yet, details about how close the regenerated SC model mimics the lipid properties (e.g. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.005DOI Listing

Biosynthesis of long-chain polyunsaturated fatty acids in the razor clam Sinonovacula constricta: Characterization of four fatty acyl elongases and a novel desaturase capacity.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education of China, Ningbo, Zhejiang 315211, China. Electronic address:

As an unusual economically important aquaculture species, Sinonovacula constricta possesses high levels of long-chain polyunsaturated fatty acids (LC-PUFA). Previously, our group identified fatty acyl desaturases (Fad) with Δ5 and Δ6 activities in S. constricta, which was the first report of Δ6 Fad in a marine mollusc. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.004DOI Listing

Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China. Electronic address:

Exaggerated endothelial pro-inflammatory response is a hallmark in the early stage of sepsis and contributes to the subsequent tissue injury and organ failure. The anti-inflammatory effects of AMP-activated protein kinase (AMPK) activator metformin in sepsis has been revealed. However, the underlying mechanisms remain not fully understood. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.04.009DOI Listing

Antileishmanial activity of H1-antihistamine drugs and cellular alterations in Leishmania (L.) infantum.

Acta Trop 2019 Apr 16. Epub 2019 Apr 16.

Center for Parasitology and Mycology, Instituto Adolfo Lutz, Sao Paulo, Brazil. Electronic address:

Leishmaniases are infectious diseases caused by protozoan parasites Leishmania and transmitted by sand flies. Drug repurposing is a therapeutic approach that has shown satisfactory results in their treatment. Analyses of antihistaminic drugs have revealed their in vitro and in vivo activity against trypanosomatids. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.017DOI Listing

Prevalence and Molecular Epidemiology of Johne's Disease in Egyptian Cattle.

Acta Trop 2019 Apr 16. Epub 2019 Apr 16.

Department of Reproductive Diseases, Animal Reproduction Research Institute, ARC, Giza, Egypt.

Johne's disease is chronic enteric incurable disease in ruminant, is caused by Mycobacterium avium subsp. paratuberculosis (MAP). The data about incidence and economic importance of the disease in Egypt are scare. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.019DOI Listing
April 2019
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Clinical performance of non-criteria antibodies to phospholipids in Chinese patients with antiphospholipid syndrome.

Clin Chim Acta 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China. Electronic address:

Background: Increasing evidence suggests the role of non-criteria aPLs as important supplements to the current criteria aPLs in APS. In this study, we evaluated the clinical performance of a panel of non-criteria antibodies to phospholipid antigens, including, phosphatidylserine (aPS), phosphatidylinositol (aPI), sphingomyelin (aSM), phosphatidylcholine (aPC) and phosphatidylethanolamine (aPE) in a well-defined Chinese APS cohort.

Methods: A total of 229 subjects were tested, including 86 patients with APS, 104 disease controls (DCs) and 39 healthy controls (HCs). Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.065DOI Listing

Circulating PCSK9 concentrations are increased in postmenopausal women with the metabolic syndrome.

Clin Chim Acta 2019 Apr 16. Epub 2019 Apr 16.

School of Allied Health Sciences, Walailak University, 222 Thaiburi, Thasala, Nakhon Si Thammarat, Thailand. Electronic address:

Background: High PCSK9 concentrations are associated with an increased risk of cardiovascular disease (CVD). We investigated PCSK9 concentrations and their association with metabolic parameters in Thai subjects and to compare PCSK9 concentrations in pre- and postmenopausal women with and without metabolic syndrome (MetS).

Methods: Anthropometric data, serum lipids, fasting blood glucose (FBG), and PCSK9 concentrations were measured in 436 Thai subjects (152 men, 143 premenopausal, and 141 postmenopausal women). Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.067DOI Listing

Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis.

Biochim Biophys Acta Biomembr 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemistry, Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra 400076, India. Electronic address:

Lipid structure critically dictates the molecular interactions of drugs with membranes influencing passive diffusion, drug partitioning and accumulation, thereby underpinning a lipid-composition specific interplay. Spurring selective passive drug diffusion and uptake through membranes is an obvious solution to combat growing antibiotic resistance with minimized toxicities. However, the spectrum of complex mycobacterial lipids and lack thereof of suitable membrane platforms limits the understanding of mechanisms underlying drug-membrane interactions in tuberculosis. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.04.004DOI Listing

Parental height modifies the association between linear growth and neurodevelopment in infancy.

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Research, Innlandet Hospital Trust, Lillehammer, Norway.

Aim: To estimate the extent to which maternal and paternal height modify the association between length-for-age Z-score (LAZ) and neurodevelopmental outcomes assessed by the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III).

Methods: Baseline data from a clinical trial in 600 Nepalese infants aged 6-11 months with LAZ less than -1 were utilized. The primary exposure was the LAZ score, interaction variables were maternal and paternal height and the outcomes were Bayley-III cognitive, language and motor scaled scores. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14820
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http://dx.doi.org/10.1111/apa.14820DOI Listing
April 2019
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Systematic Review: Long-term cognitive and behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy in children without cerebral palsy.

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Neonatal Medicine, Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Aim: To evaluate long-term cognitive and behavioural outcomes of children with neonatal hypoxic-ischaemic encephalopathy in the absence of cerebral palsy.

Methods: A systematic search was performed on five databases (EMBASE, Medline, PubMed, Web of Science, PsycInfo). Randomised-controlled trials, non-randomised controlled trials, or observational studies, published between 1990-2017, that reported long-term (age ≥ 4 years) cognitive and/or behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy without cerebral palsy were included. Read More

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http://dx.doi.org/10.1111/apa.14821DOI Listing

Cohort study showed that growth rate increment has not been enough to prevent growth retardation of preterm infants and raised concerns about unbalanced growth.

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Neonatology Department, Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Madrid, Spain.

Aim: We describe the postnatal weight gain, linear and head growth trends of surviving preterm infants from 2005 to 2017.

Methods: Multicentre cohort study, including surviving preterm infants < 32 weeks (n=21,084), from the Spanish Neonatal Network database, without major congenital malformations who were less than 50 weeks postmenstrual age at discharge. Outcomes were weight gain (g/kg/day), linear and head growth (cm/week) and changes in weight, length and head circumference z-scores from birth to discharge. Read More

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http://dx.doi.org/10.1111/apa.14819DOI Listing

Parental stress in a sample of children with epilepsy.

Acta Neurol Scand 2019 Apr 19. Epub 2019 Apr 19.

Child and Adolescent Neuropsychiatry, Medical School, University of Salerno, Via Giovanni Paolo II, 132, Fisciano (SA), Italy.

To assess maternal and paternal stress in 2 groups of children with different types of epilepsy, at the time of diagnosis and after one year of follow-up. We investigated parental stress in a sample of 85 children aged between 2-14 years, divided into two groups based on the diagnosis: Group 1 (50 patients) with Childhood Absence Epilepsy or Idiopathic Focal Epilepsy with Rolandic discharges; Group 2 (35 patients) with different forms of drug-resistant Epilepsy. Parents independently completed the Parental Stress Index-Short Form at Time 0, when they received the diagnosis and patients started therapy, and at Time 1, after 1 year of follow-up. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13106
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http://dx.doi.org/10.1111/ane.13106DOI Listing
April 2019
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Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms.

Acta Physiol (Oxf) 2019 Apr 19:e13282. Epub 2019 Apr 19.

Institute of Physiology of the Czech Academy of Sciences, Prague.

Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13282
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http://dx.doi.org/10.1111/apha.13282DOI Listing
April 2019
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GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.

Acta Physiol (Oxf) 2019 Apr 19:e13283. Epub 2019 Apr 19.

University of Navarra, Department of Nutrition, Food Science and Physiology, Pamplona, Spain.

Aim: The facilitative glucose transporter GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. GLUT12 is expressed in insulin sensitive tissues such as adipose tissue. The aim of this work was to investigate GLUT12 expression and hormonal regulation in 3T3-L1 adipocytes and in adipose tissue of lean and diet-induced obese mice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13283
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http://dx.doi.org/10.1111/apha.13283DOI Listing
April 2019
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Twenty years of development in fertility preservation of women and girls and the challenges that remain.

Acta Obstet Gynecol Scand 2019 May;98(5):543-544

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aogs.13615
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http://dx.doi.org/10.1111/aogs.13615DOI Listing
May 2019
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Aspirin reduced recurrent stroke risk in patients with lacunar stroke.

Acta Neurol Scand 2019 Apr 19. Epub 2019 Apr 19.

Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100037, China.

Objectives: Lacunar stroke had an unfavorable prognosis in the long term with a high risk of recurrent stroke, aspirin has been widely used to prevent ischemic stroke, but data on the effect of antiplatelet therapy on lacunar infarction are limited. We investigated the long-term effect of aspirin treatment on stroke recurrence risk in patients with lacunar stroke in a multicenter prospective cohort.

Methods: Between November 2000 and November 2001, 2000 consecutive stroke patients (age 35-74 years) were recruited from seven clinical centers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13105
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http://dx.doi.org/10.1111/ane.13105DOI Listing
April 2019
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Criticism upon the systematic review (SR) 'Centric relation-intercuspal position discrepancy and its relationship with temporomandibular disorders'.

Authors:
A J J Zonnenberg

Acta Odontol Scand 2019 May;77(4):248-249

a ZahnMedizinische Kliniken , University of Bern , Switzerland.

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http://dx.doi.org/10.1080/00016357.2019.1594360DOI Listing

A systematic review of observational studies of trifluridine/tipiracil (TAS-102) for metastatic colorectal cancer.

Acta Oncol 2019 Apr 19:1-9. Epub 2019 Apr 19.

e Department of Oncology , Zealand University Hospital , Roskilde , Denmark.

Background: The treatment options for patients with therapy refractory metastatic colorectal cancer (mCRC) are sparse. TAS-102 (FTD/TPI) is a new oral anti-tumour agent composed of a nucleoside analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil, indicated for patients with mCRC who are refractory to standard therapies. This study summarizes published and unpublished experience with FTD/TPI in clinical practice settings. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1605192DOI Listing

Tumor necrosis correlates with PD-L1 and PD-1 expression in lung adenocarcinoma.

Acta Oncol 2019 Apr 19:1-8. Epub 2019 Apr 19.

b 2nd Department of Pathology, MTA-SE NAP Brain Metastasis Research Group Hungarian Academy of Sciences , Semmelweis University , Budapest , Hungary.

Background: Predictive biomarkers for immunotherapy in lung cancer are intensively investigated; however, correlations between PD-L1/PD-1 expressions and clinical features or histopathological tumor characteristics determined on hematoxylin and eosin stained sections have not extensively been studied.

Material And Methods: We determined PD-L1 expression of tumor cells (TC) and immune cells (IC), and PD-1 expression of IC by immunohistochemistry in 268 lung adenocarcinoma (LADC) patients, and correlated the data with smoking, COPD, tumor grade, necrosis, lepidic growth pattern, vascular invasion, density of stromal IC, and EGFR/KRAS status of the tumors.

Results: There was a positive correlation between PD-L1 expression of TC and IC, as well as PD-L1 and PD-1 expression of IC. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2019.1
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http://dx.doi.org/10.1080/0284186X.2019.1598575DOI Listing
April 2019
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Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis: a prospective cohort study.

Acta Obstet Gynecol Scand 2019 Apr 18. Epub 2019 Apr 18.

Department of Women and Children's Health, King's College London, London, UK.

Introduction: Shock Index (SI) is a predictor of hemodynamic compromise in obstetric patients. The Shock Index threshold for action is not well understood. We aimed to evaluate Shock Index thresholds as predictors of outcomes in obstetric patients. Read More

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http://dx.doi.org/10.1111/aogs.13626DOI Listing

Contraception after pregnancy.

Acta Obstet Gynecol Scand 2019 Apr 18. Epub 2019 Apr 18.

University of Milan, Milano, Lombardia, Italy.

Whatever the outcome, pregnancy provides the opportunity to offer effective contraception to couples motivated to avoid another pregnancy. This narrative review summarises the evidence for health providers, drawing attention to current guidelines, on which contraceptive methods can be used, and when they should be started after pregnancy, whatever its outcome. Fertility returns within one month of the end of pregnancy unless breastfeeding occurs. Read More

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http://dx.doi.org/10.1111/aogs.13627DOI Listing

Minimally invasive anterior cervical discectomy and fusion: a valid alternative to open techniques.

Authors:
Marcel Ivanov

Acta Neurochir (Wien) 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Glossop Rd, Sheffield, South Yorkshire, S10 2JF, UK.

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http://dx.doi.org/10.1007/s00701-019-03905-5DOI Listing

Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death.

Acta Pharmacol Sin 2019 Apr 18. Epub 2019 Apr 18.

College of Bioengineering, Henan University of Technology, Zhengzhou, 450001, China.

Excessive and abnormal vessel growth plays a critical role in the pathogenesis of many diseases, such as cancer. Angiogenesis is one of the hallmarks of cancer growth, invasion, and metastasis. Discovery of novel antiangiogenic agents would provide new insights into the mechanisms of angiogenesis, as well as potential drugs for cancer treatment. Read More

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http://www.nature.com/articles/s41401-019-0224-x
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http://dx.doi.org/10.1038/s41401-019-0224-xDOI Listing
April 2019
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Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice.

Acta Pharmacol Sin 2019 Apr 18. Epub 2019 Apr 18.

Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

The pathogenesis of Alzheimer's disease (AD) is characterized by both accumulation of β-amyloid (Aβ) plaque and formation of neurofibrillary tangles in the brain. Recent evidence shows that autophagy activation may potently promote intracellular Aβ clearance. Thus targeting autophagy becomes a promising strategy for discovery of drug leads against AD. Read More

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http://dx.doi.org/10.1038/s41401-019-0220-1DOI Listing

"Mixed" Myeloproliferative Neoplasm Due to Co-Occurrence of Different Driver Mutations.

Authors:
Isabelle Plo

Acta Haematol 2019 Apr 18;141(4):268-270. Epub 2019 Apr 18.

INSERM, UMR1170, Laboratory of Excellence GR-Ex, Villejuif, France,

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http://dx.doi.org/10.1159/000498979DOI Listing

Experimental and theoretical insights on the effect of solvent polarity on the photophysical properties of a benzanthrone dye.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 3;218:221-228. Epub 2019 Apr 3.

Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Benzanthrone derivatives show interesting solvent dependent photophysical properties. Understanding of their photophysical properties is essential for developing the fluorescence probes based on benzanthrone derivatives. The photophysical properties of 3-(N'-chlorophenyl)piperazino-7H-benzo[de]anthracen-7-one [ClPh-PBA] molecule are reported in different solvents and solvent mixtures. Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.001DOI Listing

Altered dynamics may drift pathological fibrillization in membraneless organelles.

Biochim Biophys Acta Proteins Proteom 2019 Apr 15. Epub 2019 Apr 15.

MTA-DE Laboratory of Protein Dynamics, University of Debrecen, Hungary. Electronic address:

Protein phase transition can generate non-membrane bound cellular compartments, which can convert from liquid-like to solid-like states. While the molecular driving forces of phase separation have been largely understood, much less is known about the mechanisms of material-state conversion. We apply a recently developed algorithm to describe the weak interaction network of multivalent motifs, and simulate the effect of pathological mutations. Read More

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http://dx.doi.org/10.1016/j.bbapap.2019.04.005DOI Listing

The nanoscopic molecular pathway through human skin.

Biochim Biophys Acta Gen Subj 2019 Apr 15. Epub 2019 Apr 15.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. Electronic address:

Background: Knowledge regarding the barrier properties of human skin is important for understanding skin pathology, developing of transdermal drug delivery systems and computational skin absorption models; however, the molecular pathways through human skin remains to be fully investigated on a nanoscopic level. In particular the nanoscopic pathway of molecules passing the intercellular lipid bilayers separating the corneocytes in the stratum corneum (SC) is not fully elucidated.

Methods: Using stimulated emission depletion microscopy (STED) and Förster resonance energy transfer (FRET) the molecular pathways through the SC, the main barrier of the skin, are determined for lipophilic and water-soluble molecules at a nanoscopic resolution. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044165193008
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http://dx.doi.org/10.1016/j.bbagen.2019.04.012DOI Listing

A gradual change of chromosome mosaicism from placenta to fetus leading to T18 false negative result by NIPS.

Clin Chim Acta 2019 Apr 15. Epub 2019 Apr 15.

Department of Prenatal Diagnosis, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, China. Electronic address:

Background: Noninvasive prenatal screening (NIPS) has higher sensitivity and specificity compared to traditional prenatal screening. Nevertheless, the discordant results between the NIPS and prenatal diagnosis were occasionally reported. In current study, we investigated the genetic basis of a T18 fetus with a discordant trisomy 5 (T5) positive and trisomy 18 (T18) negative NIPS result. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.064DOI Listing

Leishmaniasis in Istanbul; A new epidemiological data about refugee leishmaniasis.

Acta Trop 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Leishmania is an intracellular parasite, which is transmitted by the bite of infected female Phlebotominae sand flies. Turkey is a crossroad between Europe and Asia that makes it important in terms of epidemiology. In the present study, we aimed to evaluate Leishmania infection among non-autochthonous patients admitted to Health Sciences University, Dr. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X193037
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http://dx.doi.org/10.1016/j.actatropica.2019.04.008DOI Listing
April 2019
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Centenarian hip fracture patients: a nationwide population-based cohort study of 507 patients.

Acta Orthop 2019 Apr 18:1-10. Epub 2019 Apr 18.

d Department of Clinical Biochemistry , Hvidovre Hospital, University of Copenhagen , Hvidovre , Denmark.

Background and purpose - Several studies suggest a global increase of centenarians during the 21st century. We describe temporal trends of hip fracture incidence and mortality in this group and compare these patients with a group of younger hip fracture patients with regards to comorbidities and mortality. Patients and methods - The full study population included all hip fractures that occurred in Denmark (n = 154,047) between 1996 and 2012. Read More

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https://www.tandfonline.com/doi/full/10.1080/17453674.2019.1
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http://dx.doi.org/10.1080/17453674.2019.1602386DOI Listing
April 2019
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Patient-reported outcomes in hip resurfacing versus conventional total hip arthroplasty: a register-based matched cohort study of 726 patients.

Acta Orthop 2019 Apr 18:1-10. Epub 2019 Apr 18.

c Swedish Hip Arthroplasty Register , Gothenburg ;

Background and purpose - The theoretical mechanical advantages of metal-on-metal hip resurfacing (MoM-HR) compared with conventional total hip arthroplasty (THA) have been questioned. Studies including measures of patient-reported function, physical activity, or health-related quality of life have been sparse. We compared patient-reported outcomes in MoM-HR patients with a matched group of patients with conventional THA at 7 years post-surgery. Read More

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http://dx.doi.org/10.1080/17453674.2019.1604343DOI Listing

The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms.

Cephalalgia 2019 Apr 18:333102419840777. Epub 2019 Apr 18.

6 University Medical Center Utrecht, Utrecht University, Department of Oral-Maxillofacial Surgery and Special Dental Care, Utrecht, the Netherlands.

Aim: To systematically review the available literature on the diagnostic accuracy of questionnaires and measurement instruments for headaches associated with musculoskeletal symptoms.

Design: Articles were eligible for inclusion when the diagnostic accuracy (sensitivity/specificity) was established for measurement instruments for headaches associated with musculoskeletal symptoms in an adult population. The databases searched were PubMed (1966-2018), Cochrane (1898-2018) and Cinahl (1988-2018). Read More

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http://dx.doi.org/10.1177/0333102419840777DOI Listing

Assessing the nephrotoxicity of intravenous iodinated contrast agents in patients with chronic renal failure in the absence of interfering acute disease.

Acta Radiol 2019 Apr 18:284185119840764. Epub 2019 Apr 18.

1 Department of Radiology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain.

Background: The existence of contrast-induced nephropathy is widely accepted. Recent studies suggest its incidence has been overestimated.

Purpose: To determine the effect of intravenous iodinated contrast agents on renal function in patients with chronic renal failure without acute disease that can interfere with the assessment of renal function. Read More

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http://dx.doi.org/10.1177/0284185119840764DOI Listing

Wash-in/wash-out phase xenon-enhanced area-detector CT (ADCT): utility for regional ventilation, pulmonary functional loss and clinical stage evaluations of smokers.

Acta Radiol 2019 Apr 18:284185119840647. Epub 2019 Apr 18.

1 Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Xenon (Xe)-enhanced area-detector computed tomography (ADCT) can visualize regional distribution of Xe within the lungs and demonstrate regional ventilation differences in smokers and patients with pulmonary diseases.

Purpose: The purpose of this study was to evaluate the capability of wash-in and wash-out (WI/WO) phase Xe-enhanced ADCT for detecting regional ventilation differences based on underlying lung conditions, pulmonary functional loss evaluation, and clinical stage prediction for smokers with and without chronic obstructive pulmonary disease (COPD).

Material And Methods: The pulmonary function test as well as inspiratory/expiratory unenhanced and WI/WO phase Xe-enhanced ADCT were prospectively administered to a group of 40 smokers consisting of 25 men (mean age ± standard deviation [SD] = 65. Read More

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http://journals.sagepub.com/doi/10.1177/0284185119840647
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http://dx.doi.org/10.1177/0284185119840647DOI Listing
April 2019
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An uncommon intraspinal mass.

Acta Neurol Belg 2019 Apr 17. Epub 2019 Apr 17.

Katholieke Universiteit Leuven Universitaire Ziekenhuizen, Leuven, Belgium.

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http://dx.doi.org/10.1007/s13760-019-01140-4DOI Listing
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