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Biochim Biophys Acta Gene Regul Mech 2022 May 23:194827. Epub 2022 May 23.

Guangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong Province 510006, PR China; Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development, Guangzhou 510640, PR China. Electronic address:

Human p53 is a transcription factor regulating the transcription of a variety of target genes. Under various stresses, its tumor suppressor function was activated by the phosphorylation of p53. In this study, we found that full-length wild-type p53 could form phase-separated condensates with the aggregation tendency in vitro and in vivo. Read More

Biochim Biophys Acta Proteins Proteom 2022 May 23:140793. Epub 2022 May 23.

Biophysics Institute, National Research Council, Palermo 90143, Italy. Electronic address:

The cblC disease is an inborn disorder of the vitamin B12 (cobalamin, Cbl) metabolism characterized by methylmalonic aciduria and homocystinuria. The clinical consequences of this disease are devastating and, even when early treated with current therapies, the affected children manifest symptoms involving vision, growth, and learning. The illness is caused by mutations in the gene codifying for MMACHC, a 282aa protein that transports and transforms the different Cbl forms. Read More

Biochim Biophys Acta Mol Basis Dis 2022 May 23:166449. Epub 2022 May 23.

Division of Endocrinology, Gerontology, and Metabolism, Stanford University, Stanford, CA, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA; Stanford Diabetes Research Center, Stanford, CA, USA. Electronic address:

There is an inverse relationship between the differentiation of mesenchymal stem cells (MSCs) along either an adipocyte or osteoblast lineage, with lineage differentiation known to be mediated by transcription factors PPARγ and Runx2, respectively. Endogenous ligands for PPARγ are generated during the hydrolysis of triacylglycerols to fatty acids through the actions of lipases such as hormone sensitive lipase (HSL). To examine whether reduced production of endogenous PPARγ ligands would influence bone regeneration, we examined the effects of HSL knockout on fracture repair in mice using a tibial mono-cortical defect as a model. Read More

Biochim Biophys Acta Mol Basis Dis 2022 May 23:166452. Epub 2022 May 23.

Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanxi 710072, China; Department of Immunology, Fourth Military Medical University, 169 West Changle Road, Xi'an, Shaanxi 710032, China. Electronic address:

CD226 is a costimulatory molecule that regulates immune cell functions in T cells, natural killer cells, and macrophages. Because macrophage-derived foam cell formation is a crucial factor contributing to the development of atherosclerosis, we aimed to evaluate the potential roles of CD226 in the pathogenesis of atherosclerosis. The effects of CD226 on atherosclerosis were investigated in CD226 and apolipoprotein E double-knockout (CD226 ApoE) mice fed with a high-cholesterol atherogenic diet. Read More

Acta Trop 2022 May 23:106538. Epub 2022 May 23.

Department of Parasitology, University of Granada, Severo Ochoa s/n, E-18071, Granada, Spain. Electronic address:

Amoebas of the genus Acanthamoeba are distributed worldwide, including species with a high pathogenic capacity for humans. In a similar way to what occurs with other parasitic protozoa, the available treatments show variable effectiveness in addition to high toxicity, which demands the development of new treatments. Positive results of 5-nitroindazole derivatives against several protozoa parasites suggest that these compounds may be a promising tool for the development of efficient antiparasitic drugs. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 1;279:121311. Epub 2022 May 1.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Science, Beijing 100012, PR China.

Soil salinization has been occurring all over the world, which severely affected crop production and threatened the life of mankind. It is necessary to take serious steps to improve soil fertility for the sustainability and productive capacity of agriculture. Soil samples of different depths were collected from native vegetation communities (Comm. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 20;279:121408. Epub 2022 May 20.

Department of Chemistry, Taiyuan Normal University, Jinzhong 030619, China.

Polyvinyl pyrrolidone (PVP), playing roles as a templating agent, can be applied to prepare blue-emitting copper nanoclusters (Cu [email protected]) on the basis of a rapid chemical reduction synthesis method. The Cu [email protected] displayed a blue emission wavelength at 430 nm and the corresponding quantum yield (QY) could reach 10.4%. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 18;279:121406. Epub 2022 May 18.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

A novel near-infrared fluorescent probe CyOE based on hemicyanine dye containing acetyl as a recognition site is reported. The probe CyOE shows high selectivity and sensitivity (LOD = 82 nM, 2.58 ppb), as well as good water solubility and quantitative detectability of hydrazine in the concentration range of 0-75 μM (R = 0. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 18;279:121405. Epub 2022 May 18.

Department of Chemistry, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chuncheon 24341, South Korea; Kangwon Radiation Convergence Research Support Center, Kangwon National University, Chuncheon 24341, South Korea. Electronic address:

Ag-ZnX (X = O, S, Se) composites coated on polystyrene (PS) arrays ([email protected], [email protected], [email protected]) were successfully fabricated by using cosputtering technology. We found that ZnX doping decreased the carrier densities of these composites compared to that of pure [email protected], which was due to redistribution of electrons between Ag and ZnX. Thus, the carrier density of Ag was decreased, and the surface plasmon resonance (SPR) of Ag was redshifted in the Ag-ZnX composites. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 17;279:121403. Epub 2022 May 17.

Ivanovo State University of Chemistry and Technology, 153000 Ivanovo, Russia; G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, 153045 Ivanovo, Russia.

The coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 coronavirus has spread rapidly around the world in a matter of weeks. Most of the current recommendations developed for the use of antivirals in COVID-19 were developed during the initial waves of the pandemic, when resources were limited and administrative or pragmatic criteria took precedence. The choice of drugs for the treatment of COVID-19 was carried out from drugs approved for medical use. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 11;279:121378. Epub 2022 May 11.

Aquaphotomics Research Department, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai, Nada, Kobe 657-8501, Japan. Electronic address:

Water spectrum of any aqueous system contains information about OH covalent and hydrogen bonds that are highly influenced by the environment and the rest of the molecules in the system. When aquaphotomics is used to analyze the water near infrared (NIR) spectra, the information about the water molecular structure can be obtained as a function of internal and external factors. The objective of this research is to apply aquaphotomics analysis to evaluate different groundwaters by using their NIR unique spectral pattern, robust to external influences of temperature and humidity, that can potentially be used for water type identification and screening practice. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 12;279:121377. Epub 2022 May 12.

Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China. Electronic address:

The excited-state proton transfer (ESIPT) behavior of organic fluorophores has been of great interest due to their unique photophysical properties. In this work, we have focused on the excited state kinetic behavior of four Schiff base organic molecules (i.e. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 11;279:121360. Epub 2022 May 11.

Nantong Key Lab of Intelligent and New Energy Materials, School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China. Electronic address:

Phosphate (Pi) plays an essential role in aquatic ecosystems as well as in physiological processes. Here, a dual-emission probe for the sensitive, specific and visual analysis of Pi is fabricated by coordinating Eu with luminol and 2,6-pyridinedicarboxylic acid (DPA). Pi can significantly enhance the characteristic fluorescence of Eu at 615 nm by promoting energy transfer from DPA to Eu and reducing the quenching effect of water molecule, luminol with inherent emission at 423 nm further enhances the Eu fluorescence. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 20;279:121409. Epub 2022 May 20.

Department of Chemistry, Amirkabir University of Technology, Tehran, Iran.

Herein, water-soluble emissive carbon quantum dots (His-CQDs) were synthesized from pyrolysis of sodium citrate in the presence of histidine under hydrothermal conditions. The as-synthesized His-CQDs were characterized using Fourier transform infrared (FT-IR), fluorescence spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM) techniques. The obtained His-CQDs display a strong emission peak at 534 nm when excited at 476 nm with a high quantum yield (61. Read More

Acta Biochim Pol 2022 May 26. Epub 2022 May 26.

Department of Anesthesiology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an City, Jiangsu Province, 223300, China.

MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity. However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown. Our study found that after oxygen-glucose deprivation/reperfusion (OGD/R) exposure, the level of miR-101 in SH-SY5Y cells was significantly decreased, which was accompanied by a decrease in cell viability, and an increase in LDH release and apoptosis. Read More

Acta Odontol Scand 2022 May 26:1-17. Epub 2022 May 26.

Department of Periodontics and Implant Dentistry, Faculty of Dentistry, Thammasat University, Phatum Thani, Thailand.

Objective: The aims of this systematic review were to evaluate the clinical masticatory performance of implant-supported restorations, observe the occlusal force changes in the distribution of the implant restoration and reveal the positive and negative contributing factors of implant design and components based on the outcomes of digital occlusal measurement.

Material And Methods: An extensive search was conducted through PubMed and CENTRAL to identify clinical trials on implant-retained restorations using digital occlusal analysis methods. Two researchers assessed the identified studies and data extraction independently, and the data synthesis strategies without meta-analysis that summarizes the effect estimates were adopted. Read More

Acta Odontol Scand 2022 May 26:1-6. Epub 2022 May 26.

Department of Oral Medicine and Pathology, Institute of Odontology, University of Gothenburg, Gothenburg, Sweden.

Objectives: To determine the prevalence and severity of dry mouth by age, gender, presence of disease, and medication intake for patients aged 18 years and over, seeking primary health care on the west coast of Sweden (Region of Västra Götaland, VGR).

Materials And Methods: Cross-sectional study conducted among patients ( = 374, age ≥ 18) visiting primary health care providers ( = 4) in VGR for any medical reasons. Patients were invited to participate by answering a single-item question, 'Have you experienced dry mouth in the last six months?' Patients giving positive answers ( = 163) were asked to fill in the 11-item Xerostomia Inventory (XI) questionnaire to determine the variability and severity of xerostomia. Read More

Acta Biochim Pol 2022 May 26. Epub 2022 May 26.

Department of Orthopaedics, Funing People's Hospital, Yancheng City, Jiangsu Province, China.

Objectives: Human bone marrow mesenchymal stem cells (BMSCs) have multi-lineage differentiation potential and have been widely researched in regenerative medicine. The purpose of this research was to explore whether Krüppel-like factor 4 (KLF4) can regulate the osteogenic differentiation of BMSCs.

Methods: We transfected human BMSCs with KLF4 overexpression plasmid and si-KLF4 to study the effects of KLF4. Read More

Acta Biochim Pol 2022 May 26. Epub 2022 May 26.

Department of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, China.

Myocardial infarction is a major cause of mortality and disability worldwide. Ischemia/reperfusion injury is the key factor that results in the increase in infarct size in pathogenesis. To find a novel therapy for myocardial infarction, we have evaluated saprirearine, a natural diterpenoid, using H9c2 cardiomyocytes injured by hypoxia/reoxygenation and explored the possible mechanisms. Read More

Acta Biochim Pol 2022 May 26. Epub 2022 May 26.

Fundamentals of Integrated Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Glaucoma is a common eye disease and a major cause of blindness. We designed brinzolamide (Brla)- and latanoprost (Ltp)-loaded nano-lipoidal carriers (NLCs) for glaucoma treatment. Brla and Ltp-loaded NLCs were designed and characterized by assessing the zeta potential, polydispersity index, X-ray diffraction and scanning electron microscopy images, and particle size. Read More

Acta Radiol 2022 May 26:2841851221101889. Epub 2022 May 26.

Laboratory of Medical Information Processing (LATIM), INSERM-UMR 1101, Brest, France.

Background: Real-time sequences allow functional evaluation of various joint structures during a continuous motion and help understand the pathomechanics of underlying musculoskeletal diseases.

Purpose: To assess and compare the image quality of the two most frequently used real-time sequences for joint dynamic magnetic resonance imaging (MRI), acquired during finger and ankle joint motion.

Material And Methods: A real-time dynamic acquisition protocol, including radiofrequency (RF)-spoiled and balanced steady-state free precession (bSSFP) sequences, optimized for temporal resolution with similar spatial resolution, was performed using a 3. Read More

Acta Parasitol 2022 May 26. Epub 2022 May 26.

Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran.

Purpose: Toxoplasmosis can induce various hormonal and behavioral alterations in humans and rodents. Previous studies revealed alterations of sex hormones; especially testosterone, in infected humans and rodents, but little is known about the effects of sex hormones on the propagation of T. gondii. Read More

Acta Parasitol 2022 May 26. Epub 2022 May 26.

Department of Veterinary Parasitology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, 125001, India.

Purpose: Porcine cysticercosis is a neglected zoonotic disease of significant veterinary and medical importance owing to its economic impact and public health significance. The present study aimed at genetic characterization of Taenia solium metacestodes in slaughtered pigs of Haryana (North India).

Methods: A total of 213 (160 and 53 from Chandigarh and Hisar, respectively) slaughtered pigs intended for human consumption were screened for the presence of T. Read More

Acta Parasitol 2022 May 26. Epub 2022 May 26.

Department of Biological Sciences, Arkansas State University (Emeritus), AZ, 72467, State University, USA.

Purpose: Nothing is known of the coccidian parasites of the Carolina wren, Thryothorus ludovicianus ludovicianus (Latham, 1790). Here, we report a new species of Isospora from T. l. Read More

Acta Parasitol 2022 May 26. Epub 2022 May 26.

Parasitology Section, South Australian Museum, North Terrace, Adelaide, SA, 5000, Australia.

Purpose: To confirm the identity of Longicollum edmondsi Golvan, 1969, Pomphorhynchidae Yamaguti, 1939, from Australia.

Methods: All the relevant specimens registered in Australian museums were examined. Those held as permanent slide preparations were examined directly and those stored in 70% ethanol were examined as temporary wet mounts, after clearing in lactophenol, using an Olympus BH-2 microscope with differential interference optics. Read More

Acta Neurol Belg 2022 May 26. Epub 2022 May 26.

Physical Medicine and Rehabilitation Department, Marmara University Medical Faculty, Marmara University Pendik Research and Training Hospital Istanbul, Istanbul, Turkey.

Introduction: Patients with Duchenne muscular dystrophy (DMD) have lost their access to on-site rehabilitation due to the COVID-19 pandemic. Telerehabilitation can be a viable approach for these patients to protect their muscle strength and functional status. The aim of this study is to compare telerehabilitation with home-based video exercises. Read More

Acta Neurol Belg 2022 May 26. Epub 2022 May 26.

Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, USA.

Acta Neurochir (Wien) 2022 May 26. Epub 2022 May 26.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.

Background: The petrous apex is one of the most challenging areas of the skull base to access.

Method: We present a case of residual petrous apex chordoma posterolateral to the paraclival segment of the internal carotid artery (ICA) resected with combined endoscopic endonasal and contralateral transmaxillary (CTM) approaches, without lateralization of the ICA.

Conclusion: This case demonstrates the value of the CTM corridor in resecting petrous apex lesions that are posterolateral to the paraclival segment of the ICA. Read More

Acta Biochim Pol 2022 May 25. Epub 2022 May 25.

School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China.

Lipid droplets (LDs) are intracellular droplets containing phospholipids and neutral lipids. It is well known that LDs are organelles with a rich proteome. In the nervous system, these droplets may play an important role in maintaining the normal physiological function of nerve cells. Read More

Acta Biochim Pol 2022 May 25. Epub 2022 May 25.

Department of Pediatric Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, Fujian, China.

Background: Glioblastoma is the most malignant primary brain tumor with dysregulated microRNAs affecting development and malignant transformation.

Methods: Gene Expression Omnibus (GEO) dataset (GSE165937) was retrieved, and the differential expressed microRNAs were screened and testified by quantitative real-time PCR (qRT-PCR) in glioblastoma cells. miR-342-3p mimic was transfected into U87MG and U251MG cells. Read More