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Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 5;261:120055. Epub 2021 Jun 5.

Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, PR China. Electronic address:

Biothiols including cysteine (Cys) and glutathione (GSH) are biological signaling molecules responsible for cell detoxification, cell metabolism and neutralization of reactive oxygen species. Here, we synthesized a long-wavelength fluorescent probe, DCIMA, for lysosome-targeted imaging of Cys and GSH in living cells. DCIMA is consisted of a dicyanoisophorone core modified with an acrylate group for biothiol detection through the Michael addition reaction and a morpholine group as the lysosome-targeting agent. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 13;261:120082. Epub 2021 Jun 13.

Nuclear Engineering Department, College of Engineering, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Cosmic rays, nuclear accidents, and neutron therapy could be sources for exposure to low-dose fast neutrons. However, the study of low dose effects needs sentient techniques to detect slight alteration happen by this low dose. Herein, the effects of low-dose fast neutrons on the structure of hemoglobin (Hb) using spectroscopic techniques, namely, Fourier transform infrared (FTIR), Raman, and ultraviolet-visible (UV-Vis) spectroscopic. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 11;261:120071. Epub 2021 Jun 11.

Leibniz Institute of Photonic Technology (IPHT), Albert-Einstein-Str. 9, D-07745 Jena, Germany; Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena D-07743, Helmholtzweg 4, Germany.

We reply to a comment made in [E. Rousseau, N. Izard, J. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 11;261:120070. Epub 2021 Jun 11.

Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, Kunming 650200, PR China. Electronic address:

Dendrobium Sw., as a traditional herb and function food with over 1500 years of history, shows a significant effect in improving immunity and fatigue resistance. However, due of course the large number of species and the quality fluctuating in different species, a fast and effective discrimination method is in need. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 11;261:120075. Epub 2021 Jun 11.

College of Information Science and Engineering, Ningbo University, Zhejiang 315211, China. Electronic address:

Tellurite glasses with combination of Er/Tm/Nd ions and silver nanoparticles (Ag NPs) were prepared by using single-step melt-quenching technology, and the enhanced effect of Ag NPs on the ultra-broadband near-infrared (NIR) fluorescence was studied. Under the 808 nm LD excitation, two ultra-broadband NIR fluorescence of 1300-1600 nm and 1600-2100 nm underwent an obvious enhancement of about 52% compared to the tri-doping tellurite glass free of Ag NPs. The intensified local electric field induced by Ag NPs together with the energy transfer from Ag species to doped ions is responsible for this enhancement. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 10;261:120063. Epub 2021 Jun 10.

Instituto de Química, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil; Instituto de Física, Universidade Federal de Goiás, 74001-970 Goiânia, GO, Brazil. Electronic address:

The present work reports the effects of meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS) aggregation on its excited states absorption spectra, triplet states quenching by molecular oxygen and singlet oxygen production. Experimental techniques such as optical absorption, Z-scan with a white light continuum source and the Laser Flash Photolysis were used to fulfil the study. J-aggregates possess reverse saturable absorption in the 505-660 nm spectral range with a peak centered close to 540 nm. Read More

Acta Biomater 2021 Jun 18. Epub 2021 Jun 18.

Department of Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia. Electronic address:

Vaccination represents the best line of defense against infectious diseases and is crucial in curtailing pandemic spread of emerging pathogens to which a population has limited immunity. In recent years, mRNA vaccines have been proposed as the new frontier in vaccination, owing to their facile and rapid development while providing a safer alternative to traditional vaccine technologies such as live or attenuated viruses. Recent breakthroughs in mRNA vaccination has been through formulation with lipid nanoparticles (LNPs), which provide both protection and enhanced delivery of mRNA vaccines in vivo. Read More

Acta Biomater 2021 Jun 18. Epub 2021 Jun 18.

Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address:

Cancer is driven by both genetic aberrations in the tumor cells and fundamental changes in the tumor microenvironment (TME). These changes offer potential targets for novel therapeutics, yet lack of in vitro 3D models recapitulating this complex microenvironment impedes such progress. Here, we generated several tumor-stroma scaffolds reflecting the dynamic in vivo breast TME, using a high throughput microfluidic system. Read More

Biochim Biophys Acta Mol Cell Res 2021 Jun 18:119082. Epub 2021 Jun 18.

Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland; Jagiellonian University Medical College, Faculty of Medicine, Chair of Pharmacology, Krakow, Poland.

Nicotinamide N-methyltransferase (NNMT, EC 2.1.1. Read More

Biochim Biophys Acta Biomembr 2021 Jun 18:183680. Epub 2021 Jun 18.

Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan; Department of Science, Graduate School of Integrated Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan; Nanomaterials Research Division, Research Institute of Electronics, Shizuoka University, Shizuoka 422-8529, Japan; Department of Physics, Faculty of Science, Shizuoka University, Shizuoka 422-8529, Japan. Electronic address:

Fluorescent-probe-labeled peptides are used to study the interactions of peptides with cells and lipid vesicles but labeling peptides with fluorescent probes can significantly change these interactions. We recently developed a new method to detect the entry of nonlabeled peptides into the lumen of single giant unilamellar vesicles (GUVs). Here we applied this method to examine the interaction of the antimicrobial peptide PGLa with single GUVs to elucidate whether PGLa can enter the GUV lumen without pore formation. Read More

Clin Chim Acta 2021 Jun 18. Epub 2021 Jun 18.

Institute for Clinical and Experimental Medicine, Department of Laboratory Methods, Vídeňská 1958/9, 140 21 Praha 4, Czech Republic; Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Praha 10, Czech Republic. Electronic address:

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in the regulation of LDL receptors. Inhibition of PCSK9 increase uptake of LDL-particles and pathogen-associated molecular patterns (PAMPs). The aim of our study was to evaluate biological variation of serum PCSK9. Read More

Clin Chim Acta 2021 Jun 18. Epub 2021 Jun 18.

Hengyang Medical College.

Sphingosine 1-phosphate (S1P), a metabolite of sphingolipids, is mainly derived from red blood cells (RBCs), platelets and endothelial cells (ECs). It plays important roles in regulating cell survival, vascular integrity and inflammatory responses through its receptors. S1P receptors (S1PRs), including 5 subtypes (S1PR1-5), are G protein-coupled receptors and have been proved to mediate various and complex roles of S1P in atherosclerosis, myocardial infarction (MI) and ischemic stroke by regulating endothelial function and inflammatory response as well as immune cell behavior. Read More

Clin Chim Acta 2021 Jun 18. Epub 2021 Jun 18.

Research Laboratory of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China. Electronic address:

Atherosclerosis, as a chronic inflammatory disease within the arterial wall, is a leading cause of morbidity and mortality worldwide due to its role in myocardial infarction, stroke and peripheral artery disease. Additional evidence is emerging that the angiopoietin-like (ANGPTL) family of proteins participate in the pathology of this disease process via endothelial dysfunction, inflammation, dyslipidemia, calcification, foam cell formation and platelet activation. This review summarizes current knowledge on the ANGPTL family of proteins in atherosclerosis related pathological processes. Read More

Clin Chim Acta 2021 Jun 18. Epub 2021 Jun 18.

Department of Medical Informatics & Decision Sciences, Yamaguchi University, Graduate School of Medicine, Ube, Yamaguchi, Japan. Electronic address:

Background: We developed a laboratory test-based regression model for early detection of hepatocellular carcinoma (HCC) associated with HCV in its surveillance.

Methods: This matched case-control study was conducted by enrolling 452 patients with chronic hepatitis and/or cirrhosis, including 129 patients complicated with HCC. One-to-one propensity score matching was performed by referring to sex, age, and fibrosis-4 index, which resulted in 102 patients each in HCC and non-HCC groups. Read More

Clin Chim Acta 2021 Jun 18. Epub 2021 Jun 18.

Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, Telangana, India, 502285.

Sepsis, which includes infection followed by inflammation, is one of the leading causes of death among neonates worldwide. The major attribute of this disease process is dysregulated host response to infection leading to organ dysfunction and potentially death. A comprehensive understanding of the host response as well as the pathogen itself are important factors contributing to outcome. Read More

Acta Odontol Scand 2021 Jun 21:1-6. Epub 2021 Jun 21.

Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.

Objective: The aim was to investigate how leading dentists and their superiors view oral health care quality, as they are in key positions to pursue high-quality care.

Materials And Methods: We interviewed five leading dentists and three of their superiors from Southern Finland via semi-structured telephone interviews including themes based on the Institute of Medicine's six quality dimensions. The material was analysed using theory-driven content analysis. Read More

Acta Biochim Biophys Sin (Shanghai) 2021 Jun 21. Epub 2021 Jun 21.

Department of Anesthesiology, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200031, China.

Sepsis is a systemic inflammatory response syndrome with high mortality. It has been reported that brefeldin A-inhibited guanine nucleotide-exchange factor 1 (BIG1) is involved in the pathogenesis of sepsis. However, the mechanism is not fully elucidated. Read More

Acta Clin Belg 2021 Jun 21:1-5. Epub 2021 Jun 21.

Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.

Introduction: The high variability of SARS-CoV-2 serological response after COVID-19 infection hampers its use as indicator of the timing of infection. A potential alternative method is the determination of affinity maturation of SARS-CoV-2 IgG, expressed as the SARS-CoV-2 IgG avidity.

Methods: SARS-CoV-2 IgG concentration and avidity were measured in sera of hospitalized COVID-19 patients sampled at two weeks and ≥12 weeks post symptom onset using an in-house developed protocol based on EUROIMMUN (anti-spike) and EDI™ (anti-nucleocapsid) SARS-CoV-2 IgG ELISA protocols. Read More

Acta Clin Belg 2021 Jun 21:1-6. Epub 2021 Jun 21.

Department of Clinical Biology, University Hospital Antwerp, Edegem, Belgium.

: In the context of the current COVID-19 pandemic, multiple serological assays for the detection of severe acute respiratory syndrome 2 (SARS-CoV-2) immune response are currently being developed. This study compares the FREND COVID-19 IgG/IgM Duo (NanoEntec) a point of care (POCT) assay with the automated Elecsys anti-SARS-CoV-2 electrochemiluminescent assay (Roche Diagnostics). Serum samples ( = 81) from PCR-confirmed SARS-CoV-2 positive patients at different time points after the onset of symptoms were analyzed with both assays. Read More

Acta Paediatr 2021 Jun 21. Epub 2021 Jun 21.

Leicester Neonatal Service, University Hospital of Leicester NHS Trust, Leicester, UK.

Acta Paediatr 2021 Jun 21. Epub 2021 Jun 21.

Birmingham Women's Hospital, Birmingham, UK.

Acta Anaesthesiol Scand 2021 Jun 21. Epub 2021 Jun 21.

Department of Paediatrics, Medical University of Innsbruck, Innsbruck, Austria.

Background: Bleeding is a common problem in children with congenital heart disease undergoing major cardiac surgery requiring cardiopulmonary bypass (CPB). Little is known about optimal management with blood products.

Objective: To investigate clinical outcome and hemostatic effects of fibrinogen concentrate (FC) in combination with prothrombin complex concentrate (PCC) versus standard treatment with fresh frozen plasma (FFP) in children undergoing cardiac surgery. Read More

Acta Anaesthesiol Scand 2021 Jun 21. Epub 2021 Jun 21.

Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Stockholm, Sweden.

Background: Prehospital tracheal intubation in trauma patients has recently been questioned. However, not only the trauma and patient characteristics but also airway provider competence differ between systems making simplified statements difficult.

Method: The study is a subgroup analysis of trauma patients included in the PHAST study. Read More

Acta Neurol Belg 2021 Jun 21. Epub 2021 Jun 21.

Cognition and Memory Studies, Yaadmaan Institute for Brain, Tehran, Iran.

The Functional Assessment Staging procedure is a clinical instrument which has been designed for staging Alzheimer's disease (AD) from the stage of no deficits to the pre-clinical stage of subjective deficits, to Mild Cognitive Impairment (MCI), to the stages of AD. This study examined the psychometric properties and the validity of the Persian version of the FAST (I-FAST) in an elderly outpatient population in Iran. We conducted a validation study of the FAST scale at the two referral centers for dementia and cognitive disorders in Tehran, Iran. Read More

Acta Biotheor 2021 Jun 21. Epub 2021 Jun 21.

Department of Botany, Hamdard University, Tughlaqabad, New Delhi, 110 062, India.

Radial growth has long been a subject of interest in tree biology research. Recent studies have brought a significant change in the understanding of some basic processes characteristic to the vascular cambium, a meristem that produces secondary vascular tissues (phloem and xylem) in woody plants. A new hypothesis regarding the mechanism of intrusive growth of the cambial initials, which has been ratified by studies of the arrangement of cambial cells, negates the influence of this apical cell growth on the expansion of the cambial circumference. Read More

Acta Neuropathol 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43) inclusions (FTLD-TDP) share the neuropathological hallmark of aggregates of TDP-43. However, factors governing the severity and regional distribution of TDP-43 pathology, which may account for the divergent clinical presentations of ALS and FTLD-TDP, are not well understood. Here, we investigated the influence of genotypes at TMEM106B, a locus associated with risk for FTLD-TDP, and hexanucleotide repeat expansions in C9orf72, a known genetic cause for both ALS and FTLD-TDP, on global TDP-43 pathology and regional distribution of TDP-43 pathology in 899 postmortem cases from a spectrum of neurodegenerative diseases. Read More

Acta Oncol 2021 Jun 21:1-2. Epub 2021 Jun 21.

Acta Clin Belg 2021 Jun 19:1-5. Epub 2021 Jun 19.

Department of Gastro-enterology, Jan Palfijn Merksem, Merksem, Belgium.

: Splenic abscesses are a rare medical entity with high mortality, with being an exceptional pathogen. We present the first case describing an abscess of the spleen in a patient undergoing treatment with adalimumab, an anti-tumour necrosis factor commonly used in inflammatory bowel diseases.: We describe the case of a 73-year-old woman, treated with adalimumab therapy, who was found to have a splenic abscess, caused by . Read More

Acta Clin Belg 2021 Jun 19:1-5. Epub 2021 Jun 19.

Center for Infectious Diseases, Queen Astrid Military Hospital, Brussels, Belgium.

: is a strictly anaerobic rod shaped bacterium belonging to the family of . It is a commensal of the human intestinal microbiota which was seldom isolated from clinical samples, therefore clinical data are scarce. To date, only four cases of infections were described, all occurring in immunosuppressed patients. Read More

Acta Cardiol 2021 Jun 21:1-9. Epub 2021 Jun 21.

Cardiology Department, Abderrahmane Mami's Hospital, Ariana, Tunisia.

Aortic stenosis (AS) is one of the most common valvular diseases in clinical practice. The prevalence of calcified AS with moderate or severe stenosis exceeds 2% after 75 years. The optimal timing of intervention for asymptomatic severe AS is uncertain and controversial. Read More