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Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 8;258:119790. Epub 2021 Apr 8.

The Institute of Chemical Physics, Key Laboratory of Cluster Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China.

Tropospheric aerosols are usually complex mixtures of inorganic and organic components, which show non-ideal behavior in hygroscopicity, mass transfer, and partitioning between gas and aerosols. In this study, we applied a novel approach based on a combination of a pulse RH controlling system and a rapid scan vacuum FTIR spectrometer to investigate the mass transfer limit of magnesium sulfate/glutaric acid (GA) mixture aerosol particles. The liquid water band area of the aerosols is used to reveal the mass transfer limit during the rapid pulse RH downward and upward processes. Read More

Biochim Biophys Acta Proteins Proteom 2021 May 1:140670. Epub 2021 May 1.

Institute for Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI, GBsC-CSIC-BIFI, Universidad de Zaragoza, 50018 Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), 50009 Zaragoza, Spain; Fundación ARAID, Government of Aragón, 50018 Zaragoza, Spain; Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50009 Zaragoza, Spain; Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain.

RYBP (Ring1 and YY1 binding protein, UniProt ID: Q8N488) is an epigenetic factor with a key role during embryonic development; it does also show an apoptotic function and an ubiquitin binding activity. RYBP is an intrinsically disordered protein (IDP), with a Zn-finger domain at its N-terminal region, which folds upon binding to DNA. It is predicted that RYBP has a nuclear localization sequence (NLS), comprising residues Asn58 to Lys83, to allow for nuclear translocation. Read More

Acta Biomater 2021 May 1. Epub 2021 May 1.

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada; School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada. Electronic address:

Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging. Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology. By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled. Read More

Acta Biomater 2021 May 1. Epub 2021 May 1.

Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland. Electronic address:

In cases of aortic stenosis, bioprosthetic heart valves (BHVs), with glutaraldehyde-fixed bovine pericardium leaflets (GLBP), are often implanted to replace the native diseased valve. Widespread use of BHVs, however, is restricted due to inadequate long-term durability, owing specifically to premature leaflet failure. Mechanical fatigue damage and calcification remain the primary leaflet failure modes, where glutaraldehyde treatment is known to accelerate calcification. Read More

Biochim Biophys Acta Mol Cell Biol Lipids 2021 May 1:158963. Epub 2021 May 1.

Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. Electronic address:

The biogenesis of peroxisomes in relation to the trafficking of proteins to peroxisomes has been extensively examined. However, the supply of phospholipids, which is needed to generate peroxisomal membranes in mammals, remains unclear. Therefore, we herein investigated metabolic alterations induced by clofibric acid, a peroxisome proliferator, in the synthesis of phospholipids, particularly phosphatidylethanolamine (PE) molecular species, and their relationship with the biogenesis of peroxisomal membranes. Read More

Biochim Biophys Acta Rev Cancer 2021 May 1:188554. Epub 2021 May 1.

Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is characterized by early metastasis, low resectability, high recurrence, and therapy resistance. The experimental mouse models have played a central role in understanding the pathobiology of PDAC and in the preclinical evaluation of various therapeutic modalities. Different mouse models with targetable pathological hallmarks have been developed and employed to address the unique challenges associated with PDAC progression, metastasis, and stromal heterogeneity. Read More

Biochim Biophys Acta Rev Cancer 2021 May 1:188557. Epub 2021 May 1.

The Patrick G Johnston Centre for Cancer Research, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK. Electronic address:

Pancreatic cancer remains an extremely deadly disease, with little improvement seen in treatment or outcomes over the last 40 years. Targeted monoclonal antibody therapy is one area that has been explored in attempts to tackle this disease. This review examines antibodies that have undergone clinical evaluation in pancreatic cancer. Read More

Acta Trop 2021 May 1:105945. Epub 2021 May 1.

Department of Biological Sciences, University of Medical Sciences, Ondo, Ondo State, Nigeria. Electronic address:

Schistosomiasis continues to pose significant public health problems in many developing countries. Mass drug administration (MDA) is the most adopted control option but there is increasing evidence for the development of praziquantel-resistant Schistosoma strains. This shortcoming has necessitated the search for other effective methods for the control of schistosomiasis. Read More

Biochim Biophys Acta Mol Cell Res 2021 May 1:119047. Epub 2021 May 1.

University of Florida Health Cancer Center, and University of Florida, Department of Medicine, Division of Hematology and Oncology, Gainesville, FL 32610. Electronic address:

The BH-3 mimetic venetoclax overcomes apoptosis and therapy resistance caused by high expression of BCL2 or loss of BH3-only protein function. Although a promising therapy for hematologic malignancies, increased expression of anti-apoptotic MCL-1 or BCL-XL, as well as other resistance mechanisms prevent a durable response to venetoclax. Recent studies demonstrate that agents targeting epigenetic mechanisms such as DNA methyltransferase inhibitors, histone deacetylase (HDAC) inhibitors, histone methyltransferase EZH2 inhibitors, or bromodomain reader protein inhibitors may disable oncogenic gene expression signatures responsible for venetoclax resistance. Read More

Acta Ophthalmol 2021 May 4. Epub 2021 May 4.

Department of Ophthalmology, St. Michael's Hospital/Unity Health Toronto, Toronto, Canada.

Diabetic macular oedema (DME) is considered a chronic inflammatory disease associated with aberrations in many intraocular cytokines. Studies assessing the role of these cytokines as biomarkers in the diagnosis and management of DME have demonstrated inconsistent findings. We quantitatively summarized data related to 116 candidate aqueous and vitreous inflammatory cytokines as biomarkers in DME. Read More

Acta Ophthalmol 2021 May;99(3):239

Department of Ophthalmology, University of Iceland, National University Hospital, Reykjavik, Iceland.

Acta Ophthalmol 2021 May 9;99(3):260-268. Epub 2020 Aug 9.

Ophthalmology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.

Purpose: To compare the effects of ageing and glaucoma progression on the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and to evaluate the performance of a set of optical coherence tomography (OCT) progression analyses.

Methods: The cpRNFL was measured twice by OCT at each of two visits made 10 years apart in 69 healthy individuals and 49 glaucoma patients. Both visits also included Humphrey 24-2 SITA standard testing. Read More

Acta Vet Hung 2021 Apr 29. Epub 2021 Apr 29.

Acta Odontol Scand 2021 May 1;79(4):296-301. Epub 2020 Dec 1.

Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden.

Background: Dentists are often exposed to occupational health hazards such as stress, high workload, and ergonomic and mental strain. However, there are limited studies focussing on occupational health and factors associated with working conditions. The aim of this study was to identify possible gender differences and factors associated with a high workload. Read More

Acta Oncol 2021 May 4:1-9. Epub 2021 May 4.

Department of Oncology and Pathology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

Inherited pathogenic variants (PVs) in the gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancreatic cancer. In this study, the testing, carried out in Sweden in the years 2015-2020, was evaluated. Read More

Acta Biochim Pol 2021 May 4. Epub 2021 May 4.

Department of Inmunobioquímica, Instituto Nacional de Perinatología "Isidro Espinoza de los Reyes" (INPerIER), Ciudad de México, México.

Pseudomonas aeruginosa, is an opportunistic bacterium with a high prevalence in diverse pulmonary infections. Although several genes are involved in the system of resistance and evasion of the immunological response of the host, little is known about the inflammatory, degradative, and cell-binding response induced by P. aeruginosa in human lung alveolar epithelial cells. Read More

Acta Neuropathol 2021 May 4. Epub 2021 May 4.

Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.

Acta Biomed 2021 Apr 30;92(S1):e2021035. Epub 2021 Apr 30.

Internal Department of Shohaday-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Marijuana is a widely used illicit substance among young adults and its abuse has been reported worldwide. Marijuana is a rare trigger of acute myocardial infarction and acute pancreatitis. We present a 25-year-old man with acute pancreatitis subsequently complicated by acute ST-elevation myocardial infarction (STEMI), which was associated with marijuana abuse. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021052. Epub 2021 Apr 30.

Department of Interventional and Diagnostic Radiology Azienda Ospedaliero-Universitaria Pisana.

Migration of calcification within the bone leading to greater tuberosity osteolysis is a peculiar complication of the calcifying tendinitis of the rotator cuff. The case of a 38-year-old woman complaining of right shoulder pain, which had been going on for one year, is hereby described. The evolution of the infraspinatus tendon calcifying tendinitis leading to osteolysis of the greater tuberosity of the humerus is depicted by imaging and, particularly, by the MR and CT features changing over time. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021080. Epub 2021 Apr 30.

Emergency Department, University Hospital of Parma, Italy.

Spinal cord infarction is a rare but severe disorder, consistently less frequent than ischemic brain injury. It constitutes only 1-2% of all neurological vascular emergencies. Here we describe a case of spinal cord infarction in a 68-year-old Caucasian man without any neurological problem in his clinical history. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021081. Epub 2021 Apr 30.

king abdulaziz university hospital.

subcutaneous fat necrosis is a benign and often self-limiting inflammatory disorder experienced by newborns who were exposed to perinatal stress in the form of asphyxia, hypothermia, cord prolapse, and/or sepsis. lesions are usually benign and self-limiting, with complete resolution anticipated within a few weeks up to 6 months. they can be accompanied by multiple complications. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021084. Epub 2021 Apr 30.

University of Padova.

An intraosseous lipoma is considered one of the rarest primary bone tumors. The etiology of this lesion remains unclear; many lesions are asymptomatic and appear only as incidental findings during routine radiographic evaluations. Magnetic resonance imaging of intraosseous lipomas can help to establish a diagnosis and to stage the neoplasm. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021085. Epub 2021 Apr 30.

ABIA STATE UNIVERSITY TEACHING HOSPITAL ABA.

We report a case of childhood vesiculobulous disorder of the severity of Toxic Epidermal Necrolysis(TEN) in a 4 year ten month old female child resulting from caregiver prescribed medication. She is one of 4 children of a non consanguineous marriage with no family history of similar adverse drug reactions. She was initially managed in a private hospital before referral to our centre where we observed constraints of funds and crisis of confidence on the part of the parents. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021086. Epub 2021 Apr 30.

Neuro-urology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Patients with neurogenic lower urinary tract dysfunction (NLUTD), specially with indwelling bladder catheter (iBC), have an increased risk of developing bladder stones, incomplete bladder emptying, recurrent urinary tract infections, sepsis, urethral trauma and bladder cancer. We present the case of a patient with a large bladder stone in iatrogenic NLUTD treated with iBC for about 30 years, who underwent a cystectomy followed by several life-threatening complications. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021089. Epub 2021 Apr 30.

Academy of Emergency Medicine and Care (AcEMC), Pavia, Italy.

The term rhabdomyolysis describes a damage involving striated muscle cells or fibers, often complicated by acute kidney injury. This syndrome can have different causes, but it is generally divided into two main categories: traumatic and non-traumatic rhabdomyolysis. Among medical causes, drugs and abuse substances play a pivotal role, being opioids, alcohol, cocaine and other substances of abuse. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021060. Epub 2021 Apr 30.

University of L'Aquila .

Hemophagocytic lymphohistiocytosis (HLH) is a rare hematologic syndrome presenting either as an inherited life-threatening inflammatory disorder in children or as a secondary disease in adults. Inherited HLH involves inborn defects in lymphocytes and includes autosomal recessive and X-linked disorders characterized by uncontrolled activation of T cells and macrophages and overproduction of inflammatory cytokines. Secondary or acquired HLH occurs in the settings of infections, systemic connective tissue disease and lymphoid malignancies, possibly due to underlying genetic predisposition to develop HLH. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021090. Epub 2021 Apr 30.

UOC Neurologia, Department of Systems Medicine, University of Tor Vergata.

Efficacy, safety and tolerability of lacosamide in the treatment of status epilepticus are well described. However, other evidence of its pharmacologic profile in elderly patients with other comorbidities seems warranted. We describe the case of an 80 year-old woman with an history of arterial hypertension, ischemic cardiomyopathy, COPD, CKD, previous laryngeal cancer, a stoma positioning for diverticular disease and previous surgery for a left frontal meningioma. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021041. Epub 2021 Apr 30.

University of Health Sciences Tepecik Training and Research Hospital Izmir.

Background: Vulvar hematoma is often puerperal. A case of non-puerperal vulvovaginal hematoma is rare in the literature. There is no consensus on the management of vulvovaginal hematoma. Read More

Acta Biomed 2021 Apr 30;92(S1):e2021043. Epub 2021 Apr 30.

Rizzoli-Sicilia Department, IRCCS Istituto Ortopedico Rizzoli.

Background: The giant haemorrhagic bursitis of the hip joint is a rare clinical condition that requires evidence-based guidelines for adequate diagnosis and management. Usually, this pathology requires conservative treatment; however, when abnormal size or clinical symptoms of compression of the surrounding noble structures are reported, an accurate differential diagnosis is required, in order to exclude other malignant conditions that can be included into differential diagnosis, and a surgical approach should be considered. The purpose of this work is to provide an appropriate description of the diagnostic and therapeutic path, providing an accurate analysis of the possible differential diagnoses. Read More