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Acta Biomater 2019 Apr 19. Epub 2019 Apr 19.

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

We recently developed a surface treatment, "precursor of apatite" (PrA), for polyetheretherketone (PrA-PEEK) via a simple, low-temperature process aiming to achieve stronger and faster adhesion to bone. The treatment involves three steps: HSO immersion, exposure to O plasma discharge, and alkaline simulated body fluid (alkaline SBF) treatment. This method produces homogeneous fine particles of amorphous calcium phosphate on the PEEK, and we confirmed that PrA-PEEK had excellent apatite formation ability in an SBF immersion test. Read More

Clin Chim Acta 2019 Apr 19. Epub 2019 Apr 19.

Nephrology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Nephrology Department, Serdang Hospital, Selangor, Malaysia.

Introduction: Chronic kidney disease (CKD) is a silent disease. Most CKD patients are unaware of their condition during the early stages of the disease which poses a challenge for healthcare professionals to institute treatment or start prevention. The trouble with the diagnosis of CKD is that in most parts of the world, it is still diagnosed based on measurements of serum creatinine and corresponding calculations of eGFR. Read More

Clin Chim Acta 2019 Apr 19. Epub 2019 Apr 19.

Department of Critical Care Medicine, The First People's Hospital of Jiande City, 599 Yanzhou Main Road, Jiande 311600, China.

Background: Severe traumatic brain injury (sTBI) is characterized by a high mortality. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in inflammation. We determined serum soluble TWEAK (sTWEAK) levels with respect to its prognostic ability. Read More

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

Acta Cardiol 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Royal Brompton and Harefield NHS Foundation Trust , London , UK.

Acta Physiol (Oxf) 2019 Apr 22:e13284. Epub 2019 Apr 22.

Klinik für Innere Medizin III, AG Experimentelle, Nephrologie, Universitätsklinikum Jena, Jena, Germany.

Inflammation is a natural protective response to microbial infections and tissue injury. It functions to eliminate harmful stimuli and to repair damaged tissue. The inflammatory response is initiated by different inducers of exogenous and endogenous origin. Read More

Acta Physiol (Oxf) 2019 Apr 22:e13287. Epub 2019 Apr 22.

Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

In this issue of Acta Physiologica, Karlsen et al. report original data suggesting lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with 12 weeks of resistance training in very old (83-94-years) men and women. These findings further our understanding of muscle remodelling responses to exercise at the most advanced stages of ageing, and spur additional research on the optimization of training protocols to combat muscle loss. Read More

Acta Neurol Scand 2019 Apr 22. Epub 2019 Apr 22.

Centre for Prehospital Research, Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden.

Background: Symptoms related to stroke diverge and may mimic many other conditions.

Aims: To evaluate clinical findings among patients with a clinical suspicion of stroke in a prehospital setting and find independent predictors of a final diagnosis of stroke or transient ischemic attack (TIA) METHODS: An observational multi-centre study including nine emergency hospitals in western Sweden. All patients transported to hospital by ambulance and in whom a suspicion of stroke was raised by the EMS clinician before hospital admission during a four-month period were included. Read More

Acta Chir Belg 2019 Apr 22:1-13. Epub 2019 Apr 22.

a Department of General Surgery , Affiliated Hospital of Yanbian University , Yanji , Jilin 133000 , China.

Background: Various technical interventions have been suggested to decrease the frequency of postoperative pancreatic fistulas but the effect is not particularly satisfactory. We have analyzed our application of bilateral U-sutures in pancreatico- jejunostomy.

Methods: The pancreatic stump is freed over approximately 2 cm, an appropriate diameter silicone catheter with 2-4 lateral holes was inserted into the remnant pancreatic duct (>2 mm in diameter is required) over 2-3cm as a stent in 69 patients. Read More

Acta Chir Belg 2019 Apr 22:1-22. Epub 2019 Apr 22.

a Department of Hepatobiliary, Endocrine and Transplantation Surgery , Antwerp University Hospital , Belgium.

Objectives: The aim of this study is to evaluate the use of pancreatic volumetric assessment to predict exocrine and endocrine insufficiency after pancreaticoduodenectomy.

Methods: Thirty-seven patients who underwent pancreaticoduodenectomy were included in the study. Endocrine function was assessed in all patients without a history of diabetes using an oral glucose tolerance test. Read More

Acta Otolaryngol 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Department of Otorhinolaryngology Head and Neck Surgery , Beijing Anzhen Hospital, Capital Medical University , Beijing , China.

Background: Intratympanic corticosteroid (IC), intravenous batroxobin (IB) as the treatment for sudden sensorineural hearing loss (SSNHL) has been reported. However, the data on combination therapy (CT) was scarce.

Objective: The aim of this retrospective study was to compare the efficacy of IC, IB, and CT in the treatment of SSNHL with diabetes. Read More

Acta Radiol Open 2019 Apr 8;8(4):2058460119836256. Epub 2019 Apr 8.

Klinik für Radiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Intramural duodenal hematoma is a rare condition. Different imaging modalities are at hand for diagnosis.

Purpose: To identify patients with intramural duodenal hematoma and report imaging findings and clinical courses. Read More

Proc Math Phys Eng Sci 2019 Mar 13;475(2223):20180614. Epub 2019 Mar 13.

Dipartimento di Matematica e Informatica, Città Universitaria, Viale A. Doria 6, 95125 Catania, Italy.

In this article, we deal with thermal convection in an inclined porous layer modelled by the . Inertial effects are taken into account, and the physically significant rigid boundary conditions are imposed. This model is an extension of the work by Rees & Bassom (Rees & Bassom 2000 , 103-118 (doi:10. Read More

Biochim Biophys Acta Mol Basis Dis 2019 May 10;1865(5):993-1002. Epub 2018 Aug 10.

Centenary Institute, The University of Sydney, Newtown, New South Wales, 2042, Australia; The University of Sydney Faculty of Medicine and Health, New South Wales, 2006, Australia. Electronic address:

Hepatocellular carcinoma (HCC) represents ~90% of all cases of primary liver cancer and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Establishing appropriate animal models for HCC is required for basic and translational studies, especially the models that can recapitulate one of the human disease settings. Current animal models can be categorized as chemically-induced, genetically-engineered, xenograft, or a combination of these with each other or with a metabolic insult. Read More

Biochim Biophys Acta Mol Basis Dis 2019 May 6;1865(5):912-919. Epub 2018 Jul 6.

Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, S-413 45 Gothenburg, Sweden. Electronic address:

The gut microbiota affects host physiology and has evolved as an important contributor to health and disease. Gut and liver are closely connected and communicate via the portal vein and the biliary system so the liver is constantly exposed to gut-derived bacterial products and metabolites. The intestinal barrier is important for maintaining physical and functional separation between microbes in the gut and the interior of the host and disruption of the barrier function can lead to bacterial translocation and increased leakage of bacterial metabolites. Read More

Biochim Biophys Acta Mol Basis Dis 2019 May 3;1865(5):1031-1039. Epub 2018 Sep 3.

Dept. of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address:

Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and regulators. It is the most common cause of acute liver failure in the US. It is also one of the most common reasons for termination of new drugs during pre-clinical testing and withdrawal of new drugs post-marketing. Read More

Acta Clin Belg 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Interuniversity Center for Health Economics Research , Vrije Universiteit Brussel , Brussels , Belgium.

Objectives: The most cost-effective newborn screening strategy for cystic fibrosis (CF) for Flanders, Belgium, is unknown. The aim of this study was to assess the cost-effectiveness of four existing newborn screening strategies for CF: IRT-DNA (immunoreactive trypsinogen, cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation analysis), IRT-PAP (pancreatitis-associated protein), IRT-PAP-DNA, and IRT-PAP-DNA-EGA (extended CFTR gene analysis).

Methods: Using data from published literature, the cost-effectiveness of the screening strategies was calculated for a hypothetical cohort of 65,606 newborns in Flanders, Belgium. Read More

Acta Clin Belg 2019 Apr 22:1-5. Epub 2019 Apr 22.

b Intensive Care Unit, Department of Internal Medicine , University Hospital Centre Zagreb , Zagreb , Croatia.

Objectives: Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare autoimmune disorder characterized by auto-antibodies to Willebrand factor (vWF) cleaving enzyme (ADAMTS13), resulting in unusually large vWF multimers that lead to platelet aggregation, microthrombi formation and microangiopathic hemolytic anemia. Hemolysis in aTTP is mechanical; thus, direct antiglobulin test (Coombs test) is usually negative. Multiple autoimmune conditions and various auto-antibodies have been described in the context of chronic myelomonocytic leukemia (CMML). Read More

Acta Cardiol 2019 Apr 21:1-2. Epub 2019 Apr 21.

d Cardiology Department , Bona Dea International Hospital , Baku , Azerbaijan.

Acta Paediatr 2019 Apr 21. Epub 2019 Apr 21.

Departments of Paediatrics and Clinical Genetics, Juliane Marie Centre, Copenhagen University Hospital, Copenhagen, Denmark.

Acta Anaesthesiol Scand 2019 Apr 21. Epub 2019 Apr 21.

Anesthesiology and Surgical Critical Care Medicine Department, Tours University Hospital, Tours, France.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7), also known as axotrophin, was originally identified in mouse embryonic stem cells. MARCH7 is involved in T-cell proliferation, neuronal development, and the immune system. However, its role in endometrial cancer (EC) remains unclear. Read More

Acta Histochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Anesthesiology, The Second Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China. Electronic address:

Sevoflurane is a widely used inhaled anesthetic, which triggers neuroapoptosis and oxidative damage in the developing central nervous system and cognitive dysfunction later in life. However, no effective therapeutic strategy for sevoflurane-induced deleterious effects is well developed. The purpose of the present study was to explore whether luteoline could attenuate neonatal sevoflurane exposure-triggered neurotoxicity. Read More

Acta Physiol (Oxf) 2019 Apr 21:e13286. Epub 2019 Apr 21.

Department of Internal Medicine, Division of Endocrinology Division of Endocrinology Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany.

Aim: In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC). This concept predicts that uPA is an important factor for sodium retention and that inhibition of uPA might be protective in nephrotic syndrome.

Methods: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC. Read More

Acta Paediatr 2019 Apr 21. Epub 2019 Apr 21.

Swedish Neonatal Quality Register (SNQ).

Aim: To describe the Swedish Neonatal Quality Register (SNQ) and to determine its completeness and agreement with other registers.

Methods: SNQ collects data for infants admitted to neonatal units during the first four postnatal weeks. Completeness and registers' agreement were determined crosslinking SNQ data with Swedish population registers (the Inpatient, Medical Birth and Cause of Death Registers) for a study period of five years. Read More

Acta Neurol Belg 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal Biology, School of Biology, College of Science, University of Tehran, 4155-6455, Tehran, Iran.

It is well known that glial cells are involved in pain processing. The purpose of the present study was to investigate the possible involvement of the ventral hippocampal (VH) glial cells in morphine-induced analgesia. A tail-flick apparatus was used to measure pain sensitivity in male Wistar rats that were bilaterally cannulated in the VH by stereotaxic surgery. Read More

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Movement and Clinical Neurosciences, UCL Queen Square Institute of Neurology, University College London, Rowland Hill Street, London, NW3 2PF, UK.

Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy are neurodegenerative disorders resulting in progressive motor/cognitive deficits among other symptoms. They are characterised by stereotypical brain cell loss accompanied by the formation of proteinaceous aggregations of the protein α-synuclein (α-syn), being, therefore, termed α-synucleinopathies. Although the presence of α-syn inclusions is a common hallmark of these disorders, the exact nature of the deposited protein is specific to each disease. Read More

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, 221 84, Lund, Sweden.

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer's disease) mice and found specifically expressed in microglia associated with Aβ plaques. Read More

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Acta Psychol (Amst) 2019 Apr 18;196:96-108. Epub 2019 Apr 18.

Abteilung für Allgemeine Sprachwissenschaft, Institut für Sprache und Information, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands; Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands. Electronic address:

In our interactions with people and objects in the world around us, as well as in communicating our thoughts, we rely on the use of conceptual knowledge stored in long-term memory. From a frame-theoretic point of view, a concept is represented by a central node and recursive attribute-value structures further specifying the concept. The present study explores whether and how the activation of an attribute within a frame might influence access to the concept's name in language production, focussing on the colour attribute. Read More

Acta Psychol (Amst) 2019 Apr 18;196:87-95. Epub 2019 Apr 18.

Developmental and Educational Psychology, Leiden University, the Netherlands.

This study investigated the potential of dynamic testing of geometric analogical reasoning in differentiating between the potential for learning of gifted and average-ability children (aged 9-10 years old). In doing so, it was analysed whether planning, a higher-order executive function, was related to outcomes of the dynamic test, and to instructional needs during training. Employing a pretest-training-post-test control group design, participants were split into four subgroups: gifted dynamic testing (n = 24), gifted control (n = 26), average-ability dynamic testing (n = 48) and average-ability control (n = 50). Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 13;218:299-307. Epub 2019 Apr 13.

NanoScience Center, Department of Physics, P.O. Box 35 (YN), FI-40014, University of Jyväskylä, Finland.

The molecular fingerprints of yeasts Saccharomyces cerevisiae, Dekkera bruxellensis, and Wickerhamomyces anomalus (former name Pichia anomala) have been examined using surface-enhanced Raman spectroscopy (SERS) and helium ion microscopy (HIM). The SERS spectra obtained from cell cultures (lysate and non-treated cells) distinguish between these very closely related fungal species. Highly SERS active silver nano-particles suitable for detecting complex biomolecules were fabricated using a simple synthesis route. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 2;218:293-298. Epub 2019 Apr 2.

School of Chemistry, College of Science, University of Tehran, Tehran, Iran.

A highly selective fluorescence nanosensor was built based on the functionalized SBA-15 mesoporous silica with Dinitrophenylhydrazine (DNPH). The interaction of fabricated nanosensor was studied with metals ions in aqueous media. Under optimum conditions (time 5 min, pH 7, sensor dose 0. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 15;218:281-292. Epub 2019 Apr 15.

National System of Laboratories in Nanotechnologies (SisNANO), Department of Physics, Federal University of Viçosa, Viçosa 36570-000, MG, Brazil.

The complex crystals of the family of the Tutton's salt have been investigated through the numerous experimental and theoretical studies to understand their physical properties and their potential technological applications. In spite of the more than 60 years of research, there are very few studies about the electronic properties of Tutton's salt. In our present work, we have calculated the stability, electronic properties and the first theoretical study of band structure of the three different crystals of the Tutton's salt, ammonium nickel sulfate hexahydrate ((NH)Ni(SO)·6HO), ammonium nickel-copper sulfate hexahydrate ((NH)NiCu(SO)·6HO) and ammonium copper sulfate hexahydrate ((NH)Ni(SO)·6HO) with the help of periodic ab-initio calculations based on density functional theory (DFT). Read More

Biochim Biophys Acta Gene Regul Mech 2019 Apr 18. Epub 2019 Apr 18.

Department of Life Sciences and Biotechnology, University of Ferrara, Italy.

Engineered transcription factors (TF) have expanded our ability to modulate gene expression and hold great promise as bio-therapeutics. The first-generation TF, based on Zinc Fingers or Transcription-Activator-like Effectors (TALE), required complex and time-consuming assembly protocols, and were indeed replaced in recent years by the CRISPR activation (CRISPRa) technology. Here, with coagulation F7/F8 gene promoters as models, we exploited a CRISPRa system based on deactivated (d)Cas9, fused with a transcriptional activator (VPR), which is driven to its target by a single guide (sg)RNA. Read More

Acta Biomater 2019 Apr 18. Epub 2019 Apr 18.

International Centre of Electron Microscopy for Materials Science, Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Poland; AGH University of Science and Technology, Al. A. Mickiewicza 30, 30-059 Kraków, Poland. Electronic address:

Nature is an amazing source of inspiration for the design of thermal insulation strategies, which are key for saving energy. In nature, thermal insulation structures, such as penguin feather and polar bear hair, are well developed; enabling the animals' survival in frigid waters. The detailed microscopy investigations conducted in this study, allowed us to perform microstructural analysis of these thermally insulating materials, including statistical measurements of keratin fiber and pore dimensions directly from high resolution Scanning Electron Microscope (SEM) images. Read More

Acta Histochem 2019 Apr 17. Epub 2019 Apr 17.

Research Institute for Animal Production in Nitra, NAFC, Hlohovecká 2, 951 41 Lužianky, Slovak Republic; Faculty of Biotechnology and Food Science, Slovak University of Agriculture, Tr. A. Hlinku 2, 949 76 Nitra, Slovak Republic; Faculty of Animal Breeding and Biology, University of Technology and Life Sciences, Al. prof. S. Kaliskiego 7, 85 796 Bydgoszcz, Poland.

This work aimed to evaluate the effect of two distinct cryopreservation procedures - conventional slow-freezing and vitrification, on survivability and mesenchymal marker expression stability of rabbit amniotic fluid-derived mesenchymal stem cells (rAF-MSCs). Cells at passage 2 were slowly frozen, using 10% of dimethylsulfoxide, or vitrified, using 40% of ethylene glycol, 0.5 M sucrose and 18% Ficoll 70. Read More

Anal Chim Acta 2019 Aug 19;1065:98-106. Epub 2019 Mar 19.

State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University, Changsha, 410082, PR China.

The sensitive detection of tumor proto-oncogenes is indispensable because the early diagnosis and accurate treatment of genetic diseases is the key guarantee of patients' health. In this study, we proposed a novel palindromic molecular beacon (PMB) that it bases on the signal amplification strategy for ultrasensitive detection of Kras gene codon 12. PMB is designed to have two palindromic fragments at its two ends, one of which is locked via folding into a hairpin structure and the other promotes the formation of PMB duplex via intermolecular self-hybridization. Read More

Anal Chim Acta 2019 Aug 20;1065:90-97. Epub 2019 Mar 20.

School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, PR China. Electronic address:

Cystoscopy and histology are the gold standards for detection of bladder cancer. However, these methods are highly subjective, expensive, and invasive. We have developed a non-invasive method for the diagnosis of bladder cancer by detecting telomerase activity in human urine. Read More

Anal Chim Acta 2019 Aug 19;1065:79-89. Epub 2019 Feb 19.

Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom. Electronic address:

Micro ATR-FTIR spectroscopic imaging enables the visualization of two-dimensional chemical distribution at a higher spatial resolution than macro-transmission FTIR imaging approach. In this study, micro ATR-FTIR imaging was applied for analysis of a specific morphology in a spherulite of poly(3-hydroxybutyrate) (PHB). The PHB spherulites crystallized at an isothermal condition, showed the fine band structure due to the twisting lamellar crystals during the spherulite growth under the polarized optical microscope (POM). Read More

Anal Chim Acta 2019 Aug 5;1065:71-78. Epub 2019 Mar 5.

Department of Chemistry and Biochemistry, USA; Biomedical Engineering, USA; Border Biomedical Research Center, USA; Environmental Science and Engineering, University of Texas at El Paso, 500 West University Ave, El Paso, TX, 79968, USA. Electronic address:

Whooping cough also called Pertussis is a highly contagious respiratory infection that affects all age populations. Given recent pertussis outbreaks, there is an urgent need for a point-of-care (POC) device for rapid diagnosis of pertussis. Herein, we report a low-cost microfluidic POC device integrated with loop-mediated isothermal amplification (LAMP) technique for the rapid and accurate diagnosis of pertussis. Read More

Anal Chim Acta 2019 Aug 3;1065:64-70. Epub 2019 Mar 3.

Chengdu Institute of Biology, Chinese Academy of Sciences, No. 93 South Keyuan Road, Gaoxin Distinct, Chengdu, 610041, PR China. Electronic address:

In most cases, three-dimensional paper-based microfluidic analytical devices (3D-μPADs) were fabricated manually by stacking or folding methods. For the first time, digital light processing stereolithography (DLP-SLA) 3D printing technology was adopted to automatically make 3D-μPADs. In the fabrication process, a printing pause was set between two layers to allow paper to be placed in the resin tank. Read More

Anal Chim Acta 2019 Aug 2;1065:56-63. Epub 2019 Mar 2.

Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA. Electronic address:

Toxicity assay is crucial in identifying biological mechanisms, detecting disease and screening therapeutics. Single cell toxicity assay reveals heterogeneous responses of each cell without ensemble average, but still cannot indicate responses of the same individual cells to multiple treatments. This article reports an identical cell assay that can be used at high throughput to locate each cell and track its responses to multiple treatments (chemicals and radiation), thus greatly facilitates toxicity based drug screening and testing. Read More

Anal Chim Acta 2019 Aug 20;1065:49-55. Epub 2019 Mar 20.

Institute of Chemistry, Saint Petersburg State University, RU-198504, Saint Petersburg, Russia.

In this study, a novel approach for effective liquid-liquid microextraction based on deep eutectic solvent (DES) decomposition was suggested for the first time. It was established that DESs synthesized from tetrabutylammonium bromide and long-chain alcohols decomposed in aqueous phase resulting in in situ dispersion of organic phase and extraction of hydrophobic analyte(s). It this process long-chain alcohol acted as an extraction solvent and tetrabutylammonium bromide acted as a dispersive agent and promoted mass transfer between aqueous and organic phases as a salting out agent. Read More

Anal Chim Acta 2019 Aug 21;1065:40-48. Epub 2019 Mar 21.

School of Pharmacy, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, 233000, China; Department of Chemistry, Bengbu Medical University, 2600 Donghai Avenue, Bengbu, 233030, China. Electronic address:

Development of novel matrix for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is a hot-spot in research frontiers. Herein, we established novel SALDI-MS approach for the analysis of cis-diol small molecules by using boronate affinity metal-organic frameworks (BA-MOFs) as the sorbent for extraction and later as matrix for SALDI. In the meantime, the prepared BA-MOFs exhibited several significant merits, such as excellent selectivity, tolerance to interference and fast binding equilibria. Read More

Anal Chim Acta 2019 Aug 18;1065:29-39. Epub 2019 Mar 18.

School of Chemistry, SunYat-senUniversity, Guangzhou, 510275, China. Electronic address:

It remains a significant challenge for fast and high-throughput detection of trace analytes in complex samples with surface-enhanced Raman scattering (SERS) strategy due to the severe interference from matrices. In this work, a miniaturized array gas membrane separation (AGMS) device coupled with SERS was designed and drew up to eliminate matrix influence and improve the reproducibility of SERS signal during real sample analysis. The design of miniaturized AGMS tube was optimized based on quantitative calculation of its air permeability by computational fluid dynamics simulation. Read More

Anal Chim Acta 2019 Aug 27;1065:21-28. Epub 2019 Mar 27.

Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, 350108, China; The Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, 350108, China. Electronic address:

This report outlines an ultrasensitive electrochemiluminescence (ECL) sensing platform based on water-soluble tungsten oxide quantum dots (WO QDs) for the detection of dopamine (DA) released from P12 cells. The WO QDs with good stability and water solubility were prepared by a facile and green hydrothermal method, and used to modify a glassy carbon electrode (WO QDs/GCE). The proposed ECL sensor exhibited a stable and strong cathodic ECL signal when potassium peroxodisulfate (KSO) as the coreactant in aqueous solution. Read More

Anal Chim Acta 2019 Aug 18;1065:134-141. Epub 2019 Mar 18.

College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, PR China.

A novel ratiometric and reversible chemosensor 4-((2-(Benzo[d]thiazol-2-yl)phenyl)ethynyl)-N,N-diethylaniline (BT-1) based on ortho-arylethynyl benzothiazole with large Stokes shift (Δλ≈190 nm) was designed and synthesized to recognize Cu. Copper ion induces a remarkable fluorescence enhancement and causes formation of a BT-1-Cu complex. The clamp-on coordination mode of BT-1 to Cu was demonstrated using Job's plot, mass spectrum (MS) and DFT calculations. Read More

Anal Chim Acta 2019 Aug 15;1065:124-133. Epub 2019 Mar 15.

Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore, 721 102, West Bengal, India. Electronic address:

The detection and discrimination of serum albumins (SAs) has been transforming as a research work of keen interest to the scientists in recent times. This is in the root of foundation of more and more fluorescent probes to selectively identify and distinguish the SAs in the modern era of research. Fluorescence based sensors are preferably on high demand because of high sensitivity of fluorescence spectroscopy. Read More

Anal Chim Acta 2019 Aug 22;1065:12-20. Epub 2019 Mar 22.

INFIQC, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre S/N, Ciudad Universitaria, 5000, Córdoba, Argentina. Electronic address:

We are reporting an innovative building-block for the development of biosensors based on the non-covalent functionalization of multi-walled carbon nanotubes (MWCNTs) with avidin (MWCNTs-avidin). In this work, at variance with previous reports, avidin has the double role of simultaneously being the exfoliating agent of MWCNTs and the platform for anchoring different biotinylated biomolecules. The optimum dispersion was obtained by sonicating for 5. Read More