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Acta Neurochir (Wien) 2022 May 21. Epub 2022 May 21.

Department of Neurosurgery, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074, Aachen, Germany.

Purpose: Decompressive hemicraniectomy (DHC) is a potentially lifesaving procedure in refractory intracranial hypertension, which can prevent death from brainstem herniation but may cause survival in a disabled state. The spectrum of indications is expanding, and we present long-term results in a series of patients suffering from aneurysmal subarachnoid hemorrhage (SAH).

Methods: We performed a retrospective analysis of previously registered data including all patients treated for SAH between 2010 and 2018 in a single institution. Read More

Acta Neurochir (Wien) 2022 May 21. Epub 2022 May 21.

Department of Nursing, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong, 226001, China.

Background: Stigma, besides aggravating the damage caused by the disease, may also lead to unhealthy characteristics in patients and unhealthy situations in society. Individuals with acromegaly disease may suffer from stigma concerns, and the associated factors remain largely unknown. Therefore, the present cross-sectional study aimed to investigate the levels of perceived stigma in patients with acromegaly and explore the associated factors. Read More

Acta Biomater 2022 May 19. Epub 2022 May 19.

Bioengineering and Nanomedicine Group, Faculty of Medicine and Health Technology, Tampere University, 33720, Tampere, Finland. Electronic address:

Biochim Biophys Acta Gen Subj 2022 May 18:130172. Epub 2022 May 18.

Department of Physiological Sciences, Federal University of Espirito Santo, Vitória, ES, Brazil.

Although iron is a metal involved in many in vital processes due to its redox capacity, body iron overloads lead to tissue damage, including the cardiovascular system. While cardiomyopathy was the focus since the 1960s, the impact on the vasculature was comparatively neglected for about 40 years, when clinical studies correlating iron overload, oxidative stress, endothelial dysfunction, arterial stiffness and atherosclerosis reinforced an "iron hypothesis". Due to controversial results from some epidemiological studies investigating atherosclerotic events and iron levels, well-controlled trials and animal studies provided essential data about the influence of iron, per se, on the vasculature. Read More

Biochim Biophys Acta Gen Subj 2022 May 18:130173. Epub 2022 May 18.

Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy. Electronic address:

Background: Nucleophosmin 1 (NPM1) protein is a multifunctional nucleolar chaperone and its gene is the most frequently mutated in Acute Myeloid Leukemia (AML). AML mutations cause the unfolding of the C-terminal domain (CTD) and the protein delocalizing in the cytosol (NPM1c+). Marked aggregation endowed with an amyloid character was assessed as consequences of mutations. Read More

Biochim Biophys Acta Gen Subj 2022 May 18:130174. Epub 2022 May 18.

Department of Nutrition and Food Science, Kobe Women's University Graduate School of Life Sciences, 2-1 Higashisuma-aoyama, Suma-ku, Kobe 654-8585, Japan. Electronic address:

Background: Sestrin2 is a conserved protein in several species, and its expression is upregulated in cells under various environmental stresses. Sestrin2 content is involved in the function of mechanistic target of rapamycin complex 1 (mTORC1) in mouse embryonic fibroblasts and C2C12 cells.

Methods: C2C12 cells were treated with amino acid-free DMEM (AF-DMEM) for 5 h. Read More

Biochim Biophys Acta Mol Cell Res 2022 May 18:119294. Epub 2022 May 18.

Department of Animal Science, School of Agriculture, Tokai University, Kumamoto 8628652, Japan. Electronic address:

Tinagl1 (tubulointerstitial nephritis antigen-like 1) is a matricellular protein involved in female infertility and breast cancer tumorigenesis. In this study, we analyzed the function of Tinagl1 in skeletal muscle using knockout mice and cell experiments. Although primary myoblasts isolated from Tinagl1-decifient (Tinagl1) mice differentiated into normal myotubes, and treatment with recombinant Tinagl1 did not affect the proliferation or differentiation of C2C12 myoblasts, Tinagl1 mice exhibited reduced body mass and calf muscle weights compared to the control group (Tinagl1). Read More

Acta Biomater 2022 May 18. Epub 2022 May 18.

Department of Biomedical Engineering, Technion-Israel Institute of Technology. Electronic address:

Vascularization of 3D engineered tissues poses a great challenge in the field of tissue engineering. One promising approach for vascularizing engineered tissue is cocultivation with endothelial cells (ECs), which spontaneously self-assemble into a natural capillary network in the presence of supportive cells. However, the ECs do not self-assemble according to physiological hierarchy which is required to support blood supply. Read More

Clin Chim Acta 2022 May 18. Epub 2022 May 18.

Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium; Department of Cardiovascular Sciences, KU Leuven, Leuven Belgium.

Background: Recommendations on the optimal preservation of 24 h urine for the metabolic work-up in urolithiasis patients are very heterogeneous. In case two such tests with different storage condition recommendations are being analysed, multiple collections would be needed, challenging especially elderly and very young patients. We therefore aimed to evaluate the stability of urine constituents under different storage conditions. Read More

Acta Trop 2022 May 18:106522. Epub 2022 May 18.

Laboratory of BioInformatics, BioMathematics and BioStatistics. LR16IPT09; Institut Pasteur de Tunis. University Tunis-El Manar. 13, Place Pasteur. B.P. 74. Tunis-Belvedere, 1002, Tunisia. Electronic address:

Most microorganisms including Leishmania parasites compete with the innate immune defenses of the infected hosts to acquire iron, an essential nutrient necessary for their growth and replication. In mammals, iron is predominantly bound to protein carriers such as transferrin and ferritin and the strategies adopted by the infected host to restrict its uptake by pathogens are still not elucidated. We compared herein the development of anti-transferrin and anti-ferritin antibodies in hosts that differs by their susceptibility to Leishmania infection. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 14;278:121387. Epub 2022 May 14.

Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; Solar Energy Institute, Ege University, Izmir TR-35100, Turkey.

A photoactive nanohybrid material consisting of pyrocatechol violet, carminic acid and dithizone dyes functionalized silver and neodymium-doped TiO/ZnO nanostructured materials is reported here, as photoactive blend, for solid-state dye sensitized solar cell. First of all we synthesized metals (silver, neodymium) doped (TiO) Titanium oxide nanoparticles and their nanocomposites (TiO/ZnO, M-TiO/ZnO) using the sol-gel and reflux technique, respectively. The synthesized samples were then characterized by UV-Visible spectroscopy, X-Ray diffraction Analysis (XRD), Scanning electron microscopy (SEM), Energy dispersive X-Ray Analysis (EDX), and Fourier Transform infrared spectroscopy (FTIR). Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 14;278:121374. Epub 2022 May 14.

Department of Chemistry, Faculty of Sciences, UNESP - São Paulo State University, 17033-360 Bauru, São Paulo, Brazil. Electronic address:

The induction of chirality in a ligand can be a powerful analytical tool for studying protein-ligand interactions. Here, we advanced by applying the technique to monitor the inversion of the induced circular dichroism (ICD) spectrum when ligands move between human and bovine serum albumin proteins (HSA and BSA). ICD experiments were performed using dimers of methyl vanillate (DVT) and vanillin (DVN). Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 14;278:121386. Epub 2022 May 14.

Hunan Provincial Key Laboratory of Water Treatment Functional Materials, College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Changde 415000, PR China. Electronic address:

Sulfur dioxide (SO) derivatives are intertwined with many physiological and pathological processes in living systems, and excess intake of them are associated with various diseases. Herein, we have rationally constructed a novel colorimetric and far-red fluorescent probe for HSO based on a rhodamine analogue skeleton bearing a 3-quinolinium carboxaldehyde moiety. The novel probe exhibited a significant far-red fluorescence "Turn-on" response to HSO, along with obvious color change from reddish to purple via the specific 1,4-nucleophilic addition reaction of HSO with the quinolinium moiety in 3-(4-(2-carboxyphenyl)-7-(diethylamino)chromenylium-2-yl)-1-methylquinolin-1-ium hypochlorite trifluoromethanesulfonate (AQCB). Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 5;278:121331. Epub 2022 May 5.

Department of Chemistry, Central University of Haryana, Mahendergarh 123031, India. Electronic address:

Bridged dinuclear metal complexes have fascinated scientists worldwide, and remarkable success has been achieved to unravel the electronic structures, structure-function relationship, coordination environments, and fine mechanistic details of the enzymes owing to the repercussion of biomimetic studies carried out on dinuclear model systems. Molecular level study of these systems integrated with spectroscopic study helps in gaining deep insights about structural and electronic aspects of natural enzymatic systems. Considering the same, here first time we report DFT study on bridged non-heme metal complexes based on N-Et-HPTB ligand system containing homovalent (MM); {[(Mn)(OCCH)(N-Et-HPTB)]; Species I), [(Fe)(OCCH)(N-Et-HPTB)]; Species II), [(Co)(OCCH)(N-Et-HPTB)]; Species III)} and heterovalent (MM): {[(Mn)(Mn)(O)(N-Et-HPTB)]; Species Ia) [(Fe)(Fe)(O)(N-Et-HPTB)]; Species IIa) and [(Co)(Co)(O)(N-Et-HPTB)]; Species IIIa)} dinuclear metal centres. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 14;278:121385. Epub 2022 May 14.

Institute of Biomedical Materials Industry Technology, Hubei Engineering University, Xiaogan 432000, China; School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, China. Electronic address:

Diagnosis of diabetic cataract (DC) in the early stage is of great significance for drug intervention and surgery circumvention for DC patients. However, the lack of reliable imaging tools greatly limits the diagnosis of early DC. In this context, a fluorescent probe BBPy for hypochlorous acid (HOCl) is presented based on the oxidation of phenothiazine. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2022 May 14;278:121383. Epub 2022 May 14.

School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China. Electronic address:

In this article, the interaction between six fluoroquinolones (FQs) and bovine serum albumin (BSA) was initially studied at 298 K, 303 K and 310 K respectively under simulated physiological conditions by fluorescence spectroscopy. At the same time, the sub-structural domains on BSA that may bind to FQs were investigated by molecular docking simulation technique. A combination of quantitative and qualitative approaches was used in the analysis of the binding constants, binding sites and corresponding thermodynamic parameters in the interaction system, it was found that FQs forms a complex with BSA and undergoes static quenching, which is the main cause of fluorescence quenching. Read More

Acta Psychol (Amst) 2022 May 13;227:103617. Epub 2022 May 13.

School of Humanities and Management, Wannan Medical College, Wuhu, China. Electronic address:

To investigate the relationship between stress response and depression in vocational medical school students at the initial stage of COVID-19 epidemic, and to explore the mediating role of meaning in life and the moderating role of prosocial behavior. The COVID-19 Stress Response Questionnaire, the Meaning in Life Questionnaire, the Prosocial Behavior Scale and the Depression Scale, were used to investigate 3526 vocational medical school students. The results showed that: (1) The relationship between stress response and depression in vocational medical school students was partially mediated by presence of meaning and search for meaning. Read More

Acta Neurol Belg 2022 May 21. Epub 2022 May 21.

Clinic of Neurology, Prof. Dr. Cemil Taşçıoğlu City Hospital, University of Health Sciences Turkey, Istanbul, Turkey.

Acta Neurochir (Wien) 2022 May 21. Epub 2022 May 21.

Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210009, Jiangsu, China.

Objective: The most common cause for trigeminal neuralgia (TN) is vascular compression at the nerve root, and microvascular decompression (MVD) has been proven to be an effective surgical approach for this disease. For some patients, TN is secondary to the intracranial space-occupying lesion, and tumor resection is usually recommended. However, it is not easy to determine proper treatments when craniotomy is infeasible. Read More

Oral Maxillofac Surg 2022 May 21. Epub 2022 May 21.

Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center and Amstelland Hospital, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.

Purpose: This prospective cohort study aimed to assess early root migration after a coronectomy of the mandibular third molar at 2 and 6 months after surgery.

Methods: We included all patients treated with a coronectomy of an impacted mandibular third molar. The primary outcome measure was the extent of postoperative root migration after 2 and 6 months. Read More

Acta Neuropathol 2022 May 21. Epub 2022 May 21.

Department of Biology, University of Padova, Padua, Italy.

The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80% of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function is finely regulated by endocytic events, recycling to the plasma membrane and degradation. Noteworthy, deficits in EAAT2 have been associated with neuronal excitotoxicity and neurodegeneration. Read More

Acta Psychiatr Scand 2022 May 20. Epub 2022 May 20.

Global Brain Health Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland.

Objective: Little is known about the economic value of clinical interventions for delirium. This review aims to synthesise and appraise available economic evidence, including resource use, costs, and cost-effectiveness of interventions for reducing, preventing, and treating delirium.

Methods: Systematic review of published and grey literature on full and partial economic evaluations. Read More

Acta Neurol Scand 2022 May 20. Epub 2022 May 20.

Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.

Objectives: The Austrian Prehospital Stroke Scale (APSS) score was developed to predict large vessel occlusion (LVO) and improve prehospital transportation triage. Its accuracy has been previously analyzed retrospectively. We now aimed to investigate the accuracy, as well as the impact of the implementation of a triage strategy using this score on treatment times and outcome in a prospective study. Read More

Acta Neurochir (Wien) 2022 May 21. Epub 2022 May 21.

Neuroscience Institute of the Lithuanian University of Health Sciences, Kaunas, Lithuania.

Objectives: We aimed to quantitatively assess Evans index (EI) using ultrasonographic optic nerve sheath diameter (ONSD) measurements in supine and upright position in normal pressure hydrocephalus (NPH) patients.

Methods: Ultrasonographically ONSD was measured in a supine and upright position before and 4-5 days after the ventriculoperitoneal shunt surgery. The changes of the ONSD between supine and upright positions were calculated as ∆ONSD = sONSD-uONSD and as the variation ONSD_V = 100% × [(sONSD - uONSD)/sONSD]. Read More

Anal Chim Acta 2022 Jun 30;1210:339884. Epub 2022 Apr 30.

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei Province, PR China. Electronic address:

Zearalenone (ZEN) is a nonsteroidal estrogenic mycotoxin, and its accurate detection in complex biological samples is still a challenge. Herein, an antifouling ratiometric electrochemical sensor has been developed for its detection. In this system, black phosphorus-graphene oxide is used as substrate to amplify the signal; ionic liquid doped molecularly imprinted polymer (MIP) endows the sensing surface not only high recognition ability but also high capability to resist nonspecific adsorption. Read More

Anal Chim Acta 2022 Jun 29;1210:339883. Epub 2022 Apr 29.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. Electronic address:

A quenching-typed electrochemiluminescence (ECL) immunosensing method was proposed for protein detection by the redox reaction of tungsten-based polyoxometalate nanoclusters (W-POM NCs) with free radical (O) as the intermediate of co-reactant HO. The immunosensor was constructed by co-immobilizing luminol loaded CeVO/Au nanohybrids and capture antibody on an indium tin oxide electrode, which showed strong ECL emission in the presence of HO due to the catalysis of CeVO/Au toward its electro-oxidation to produce O via the reversible conversion between Ce and Ce. The W-POM NCs were encapsulated in the uniformly sized amino-silica nanosphere (SiO) to act as a label ([email protected]) of the secondary antibody. Read More

Anal Chim Acta 2022 Jun 29;1210:339882. Epub 2022 Apr 29.

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131, Naples, Italy; BAT Center - Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology, University of Naples Federico II, 80055, Naples, Italy. Electronic address:

Urea provides pathophysiological information on renal and hepatic disorders. Among the secretion pathways via several bio-fluids, sweat urea represent an important and non-invasive strategy to evaluate kidney and liver pathologies. In this work, a rapid and reliable colorimetric urea bioassay assisted by chemometrics design of experiments has been obtained. Read More

Anal Chim Acta 2022 Jun 27;1210:339879. Epub 2022 Apr 27.

Department of Chemistry, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Republic of Korea. Electronic address:

The fluctuation of the halide ion concentration in human serum is of a high clinical implication. The measurement of Cl in human serum samples is important because Cl is a major constituent of human serum and certain Cl levels are indicators of many acute diseases. Real-time monitoring of Br levels in human serum samples from patients ingesting Br salt-based antiepileptic drugs is important to regulate potential adverse drug effects. Read More

Anal Chim Acta 2022 Jun 1;1210:339889. Epub 2022 May 1.

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Electronic address:

Dried blood spots (DBS) have been regarded as a promising alternative for therapeutic drug monitoring (TDM) of immunosuppressants (ISDs) for over fifteen years. Nonetheless, there are still three main issues impeding its preference: (i) the requirement of relatively large disc; (ii) the controversial and intricate desorption approaches; (iii) the lack of feasible extraction strategies. For improvement, this work described a new LC-MS/MS method realizing quantification of four ISDs from one piece of 3. Read More

Anal Chim Acta 2022 Jun 1;1210:339887. Epub 2022 May 1.

Food Chemistry and Food Development, Department of Life Technologies, FI-20500, University of Turku, Turku, Finland. Electronic address:

Regioisomeric analysis of triacylglycerols (TAGs) in natural oils and fats is a highly challenging task in analytical chemistry. Here we present a software (TAG Analyzer) for automatic calculation of regioisomeric composition of TAGs based on the mass spectral data from recently reported ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) method for analyzing TAG regioisomers. The software enables fast and accurate processing of complex product ion spectra containing structurally informative diacylglycerol [M+NH-RCOH-NH] and fatty acid ketene [RCO] fragment ions. Read More