2,563 results match your criteria Acta Diabetologica[Journal]


Impact of applying a diabetes risk score in primary care on change in physical activity: a pragmatic cluster randomised trial.

Acta Diabetol 2022 May 13. Epub 2022 May 13.

Institute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.

Aim: There is little evidence of the impact of diabetes risk scores on individual diabetes risk factors, motivation for behaviour changes and mental health. The aim of this study was to investigate the effect of applying a noninvasive diabetes risk score in primary care as component of routine health checks on physical activity and secondary outcomes.

Methods: Cluster randomised trial, in which primary care physicians (PCPs), randomised (1:1) by minimisation, enrolled participants with statutory health insurance without known diabetes, ≥ 35 years of age with a body mass index ≥ 27. Read More

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Is HbA1c a valid surrogate for mortality in type 2 diabetes? Evidence from a meta-analysis of randomized trials.

Acta Diabetol 2022 May 9. Epub 2022 May 9.

Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.

Aims: Hemoglobin A1c (HbA1c) has been repeatedly questioned as a valid surrogate marker, especially for patient-relevant outcomes. The aim of this study was to validate the HbA1c value as a surrogate for all-cause mortality in people with type 2 diabetes.

Methods: The effect estimates for HbA1c lowering after treatment as well as reductions in all-cause mortality of randomized trials were extracted from a systematic review and updated. Read More

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Prognostic value of stress hyperglycemia ratio on short- and long-term mortality after acute myocardial infarction.

Acta Diabetol 2022 May 9. Epub 2022 May 9.

Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, Stenglinstraße 2, 86156, Augsburg, Germany.

Aims: Prior studies demonstrated an association between hospital admission blood glucose and mortality in acute myocardial infarction (AMI). Because stress hyperglycemia ratio (SHR) has been suggested as a more reliable marker of stress hyperglycemia this study investigated to what extent SHR in comparison with admission blood glucose is associated with short- and long-term mortality in diabetic and non-diabetic AMI patients.

Methods: The analysis was based on 2,311 AMI patients aged 25-84 years from the population-based Myocardial Infarction Registry Augsburg (median follow-up time 6. Read More

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A decisive bridge between innate immunity and the pathognomonic morphological characteristics of type 1 diabetes demonstrated by instillation of heat-inactivated bacteria in the pancreatic duct of rats.

Acta Diabetol 2022 Apr 24. Epub 2022 Apr 24.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala, Sweden.

Aims: Periductal inflammation and accumulation of granulocytes and monocytes in the periislet area and in the exocrine pancreas is observed within hours after instillation of heat-inactivated bacteria in the ductal compartment of the pancreas in healthy rats. The present investigation was undertaken to study how the acute inflammation developed over time.

Methods: Immunohistochemical evaluation of the immune response triggered by instillation of heat-inactivated bacteria in the ductal compartment in rats. Read More

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Circulating protein disulfide isomerase family member 4 is associated with type 2 diabetes mellitus, insulin sensitivity, and obesity.

Acta Diabetol 2022 Apr 23. Epub 2022 Apr 23.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.

Aims: Endoplasmic reticulum (ER) stress is associated with obesity and type 2 diabetes mellitus (T2DM) and increasing evidence demonstrates that some ER stress markers can represent the severity of metabolic dysfunction in either cellular or animal models. However, no appropriate molecule has been identified to demonstrate these relationships in clinical practice.

Methods: To determine whether the serum level of the ER chaperone, protein disulfide isomerase family A, member 4 (PDIA4), is associated with type 2 diabetes mellitus, obesity, and insulin sensitivity, we conducted a cross-sectional study for which a total of 553 adults, including 159 with normal glucose tolerance (NGT), 169 with prediabetes (Pre-DM), and 225 with newly diagnosed T2DM, were recruited. Read More

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Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life observational study.

Acta Diabetol 2022 Apr 22. Epub 2022 Apr 22.

Diabetes Unit, Bambino Gesù Children's Hospital, Piazza S Onofrio, 4, 00165, Rome, Italy.

Objective: The Advanced Hybrid Closed Loop (AHCL) systems have provided the potential to ameliorate glucose control in children with Type 1 Diabetes. The aim of the present work was to compare metabolic control obtained with 2 AHCL systems (Medtronic 780G system and Tandem Control IQ system) in a pediatric real-life clinical context.

Research Design And Methods: It is an observational, real-life, monocentric study; thirty one children and adolescents (M:F = 15:16, age range 7. Read More

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The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial.

Acta Diabetol 2022 Apr 22. Epub 2022 Apr 22.

Endocrinology and Diabetes Service and Diabetes Alliance Hunter New England Local Health District, New Lambton Heights, Australia.

Aims: The burden and health costs of Type 2 Diabetes Mellitus continue to increase globally and prevention strategies in at-risk people need to be explored. Previous work, in both animal models and humans, supports the role of zinc in improving glucose homeostasis. We, therefore, aimed to test the effectiveness of zinc supplementation on glycaemic control in pre-diabetic adults. Read More

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The transferability and validity of a population-level simulation model for the economic evaluation of interventions in diabetes: the MICADO model.

Acta Diabetol 2022 Apr 21. Epub 2022 Apr 21.

Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.

Aims: Valid health economic models are essential to inform the adoption and reimbursement of therapies for diabetes mellitus. Often existing health economic models are applied in other countries and settings than those where they were developed. This practice requires assessing the transferability of a model developed from one setting to another. Read More

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Urinary interleukin-9 in youth with type 1 diabetes mellitus.

Acta Diabetol 2022 Apr 20. Epub 2022 Apr 20.

Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.

Aims: Interleukin-9 (IL-9) attenuates podocyte injury in experimental kidney disease, but its role in diabetic nephropathy is unknown. We sought to relate urinary IL-9 levels to the release of podocyte-derived extracellular vesicles (EVs) in youth with type 1 diabetes. We related urinary IL-9 levels to clinical variables and studied interactions between urinary IL-9, vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) on urinary albumin/creatinine ratio (ACR) a functional measure of podocyte injury. Read More

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Diabetic sarcopenia: metabolic and molecular appraisal.

Acta Diabetol 2022 Apr 16. Epub 2022 Apr 16.

Department of Biochemistry, College of Medicine and Medical Sciences (CMMS), Arabian Gulf University (AGU), Manama, Kingdom of Bahrain.

Myopathy is the missing slot from the routine clinical checkup for diabetic complications. Similarly, its pathophysiological, metabolic, and molecular bases are insufficiently explored. In this review, the above issues are highlighted with a focus on skeletal muscle atrophy (also described as diabetic sarcopenia), in contrast to the normal histological, physiological, and molecular features of the muscles. Read More

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The effect of additional acarbose on metformin-associated artificially high F-Fluorodeoxyglucose uptake in positron emission tomography/computed tomography.

Acta Diabetol 2022 Apr 16. Epub 2022 Apr 16.

Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.

Aim: Metformin causes diffuse and intense fluorodeoxyglucose (FDG) uptake more frequently in the colon and less frequently in the small intestine. In this study, we aimed to investigate the effect of simultaneous use of acarbose and metformin on FDG uptake in positron emission tomography/computed tomography (PET/CT), which has not been investigated previously.

Methods: Totally 145 patients with a median age of 65 years (range: 18-80 years), who underwent FDG PET/CT in the Department of Nuclear Medicine of Erciyes University Medical School between 2018 and 2021, were involved in the study. Read More

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Effectiveness of adding alarms to flash glucose monitoring in adults with type 1 diabetes under routine care.

Acta Diabetol 2022 Apr 13. Epub 2022 Apr 13.

Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padova, Italy.

Aim: Whether glucose sensor alarms improve metabolic control and are accepted by individuals with diabetes is unclear. Here, we investigated whether switching from a standard flash glucose monitoring system (FGM1) to a system equipped with hypo- and hyperglycemia alarms (FGM2) improves glycemic control and psychological outcomes in adults with type 1 diabetes (T1D).

Methods: Subjects with T1D and > 4% of time in hypoglycemia or > 40% of time in hyperglycemia were studied while wearing FGM1 (4 weeks) and after switching to FGM2 for 8 weeks. Read More

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Impact of intermittently scanned continuous glucose monitoring with alarms on sleep and metabolic outcomes in children and adolescents with type 1 diabetes.

Acta Diabetol 2022 Apr 9. Epub 2022 Apr 9.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Aims: Data about sleep quality and quantity are not available in patients with type 1 diabetes (T1D) using intermittently scanned continuous glucose monitoring (isCGM). We questioned whether the isCGM with alarms could fragment sleep in patients and parents, compared to isCGM without alarms.

Methods: A prospective, observational study including 47 child-adolescents with T1D who had experience with isCGM without alarms (Freestyle Libre 1-FSL1). Read More

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Short chain fatty acids for the risk of diabetic nephropathy in type 2 diabetes patients.

Acta Diabetol 2022 Apr 3. Epub 2022 Apr 3.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, People's Republic of China.

Aims: This study aimed to explore relationships short chain fatty acids with diabetic nephropathy (DN) in type 2 diabetes (T2D) patients.

Methods: We extracted the clinical and omics data of 100 T2D patients and 100 DN patients from April 2018 to April 2019 from a tertiary hospital. Restricted cubic splines were used to examine full-range associations of short chain fatty acids with DN in T2D. Read More

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Comment on: diabetic retinopathy and cognitive dysfunction-a systematic review and meta‑analysis.

Acta Diabetol 2022 Apr 1. Epub 2022 Apr 1.

Department of Ophthalmology, Lanzhou University Second Hospital, Lanzhou, 730000, Gansu, China.

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One year of Hybrid Closed Loop on peritoneal dialysis: a case report.

Acta Diabetol 2022 Mar 30. Epub 2022 Mar 30.

Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.

Background: Automated insulin delivery is a game changer for type 1 diabetes treatment.

Objective: To describe the benefits of automated insulin delivery in a specific complex setting.

Methods: We are herein presenting a case of a patient with type 1 diabetes, in which Hybrid Closed Loop (Medtronic Minimed 670G on Auto Mode) was used over a year during automated peritoneal dialysis. Read More

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Shared exposure liability of type 2 diabetes and other chronic conditions in the UK Biobank.

Acta Diabetol 2022 Jun 29;59(6):851-860. Epub 2022 Mar 29.

Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St, Boston, MA, USA.

Aims: To investigate whether the cumulative exposure risks of incident T2D are shared with other common chronic diseases.

Research Design And Methods: We first establish and report the cross-sectional prevalence, cross-sectional co-prevalence, and incidence of seven T2D-associated chronic diseases [hypertension, atrial fibrillation, coronary artery disease, obesity, chronic obstructive pulmonary disease (COPD), and chronic kidney and liver diseases] in the UK Biobank. We use published weights of genetic variants and exposure variables to derive the T2D polygenic (PGS) and polyexposure (PXS) risk scores and test their associations to incident diseases. Read More

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Downregulation of Kcnq1ot1 attenuates β-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis.

Acta Diabetol 2022 Mar 26. Epub 2022 Mar 26.

Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.

Aim: To examine the effect of lncRNA Kcnq1ot1 on pancreatic β cells in the development of diabetes.

Methods: The expression levels of Kcnq1ot1 were detected in the islets of diabetes mouse models and the serum of patients with type 2 diabetes by qRT-PCR. CCK8, Ki67 staining, immunohistochemical analyses, glucose-stimulated insulin secretion and intraperitoneal glucose tolerance test were performed to detect the effect of Kcnq1ot1 on β-cell proliferation and insulin secretion in vitro and in vivo. Read More

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Prognostic significance of reverse dipping status on lower limb event in type 2 diabetic patients without peripheral arterial disease.

Acta Diabetol 2022 Jun 25;59(6):843-850. Epub 2022 Mar 25.

CHU Lille, University of Lille, 59000, Lille, France.

Aims: We assessed reverse dipping influence on the risk of lower limb events in type 2 diabetic patients without peripheral arterial disease.

Methods: Patients with type 2 diabetes addressed for cardiovascular risk stratification in our university hospital from 2008 to 2012 underwent 24 h blood pressure monitoring. Patients with a prior history of limb revascularization or with a stenosis > 50% of the legs were excluded. Read More

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Reply to comment on: Diabetic retinopathy and cognitive dysfunction: a systematic review and meta-analysis.

Authors:
Mei Wu Fan Mei Bin Ma

Acta Diabetol 2022 Mar 21. Epub 2022 Mar 21.

Evidence-Based Medicine Centre, School of Basic Medical Sciences, School of Nursing, Lanzhou University, Lanzhou, 730030, China.

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Novel clusters of newly-diagnosed type 2 diabetes and their association with diabetic retinopathy: a 3-year follow-up study.

Acta Diabetol 2022 Jun 21;59(6):827-835. Epub 2022 Mar 21.

Department of General Practice, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, No.87 Dingjiaqiao Street, Nanjing, 210009, People's Republic of China.

Background: Cluster analysis may assist in stratifying heterogeneous clinical presentations of type 2 diabetes (T2D). However, the association of cluster-based subgroups with diabetes-related outcomes such as diabetic retinopathy remains unclear. This study was aimed to address this issue with novel clusters of T2D derived from four simple parameters. Read More

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Significant and persistent improvements in time in range and positive emotions in children and adolescents with type 1 diabetes using a closed-loop control system after attending a virtual educational camp.

Acta Diabetol 2022 Jun 21;59(6):837-842. Epub 2022 Mar 21.

Pediatric Diabetes, Endocrinology and Nutrition, Division of Pediatrics, ASST Cremona, Cremona, Italy.

Objective: To evaluate the six-month impact of the advanced automated functions of a closed-loop control (CLC) system (Control-IQ) and a virtual educational camp (vEC) on emotions and time in range (TIR) of children and adolescents with type 1 diabetes.

Methods: Children and their parents participated in a three-day vEC. Clinical, glucose, and emotion data were evaluated before, just after, and six months after the vEC. Read More

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LitKDM2 study: the impact of health Literacy and knowledge about the disease on the metabolic control of type 2 diabetes mellitus.

Acta Diabetol 2022 Jun 19;59(6):819-825. Epub 2022 Mar 19.

Family Health Unit St. André de Canidelo, R. das Fábricas, 282, 4400-712, Vila Nova de Gaia, Portugal.

Aims: Diabetes mellitus (DM) is a common chronic disease with serious individual and socioeconomic consequences. Low health literacy (HL) has been associated with higher morbimortality. Health knowledge about DM (HK-DM) may also influence individual health. Read More

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Gestational diabetes in twin pregnancy: A predictor of adverse fetomaternal outcomes?

Acta Diabetol 2022 Jun 17;59(6):811-818. Epub 2022 Mar 17.

Division of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário Do Porto, Largo Professor Abel Salazar, 4099-001, Porto, Portugal.

Aim: To compare fetomaternal outcomes between GDM pregnant women with twin versus singleton pregnancies and then between women with GDM versus non-GDM twin pregnancies.

Methods: We performed a retrospective study including GDM pregnant women with both twin and singleton pregnancies followed in our tertiary center between 2011 and 2018. The fetomaternal characteristics of each group were compared. Read More

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Diabetes mellitus tendino-myopathy: epidemiology, clinical features, diagnosis and management of an overlooked diabetic complication.

Acta Diabetol 2022 Mar 15. Epub 2022 Mar 15.

Department of Internal Medicine, Faculty of Medicine and Health Sciences, Alneelain University, Khartoum, Sudan.

Tendino-myopathy, an unexplored niche, is a non-vascular unstated T2DM complication, which is largely disregarded in clinical practice, thus, we aim to explore it in this review. Literature search using published data from different online resources. Epidemiologically, reported prevalence varies around 10-90%, which is marked variable and unreliable. Read More

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Italian guidelines for the treatment of type 2 diabetes.

Acta Diabetol 2022 05 15;59(5):579-622. Epub 2022 Mar 15.

Diabetology, Azienda Ospedaliero-Universitaria Careggi, Careggi Hospital, University of Florence, Largo Brambilla, 50134, Florence, Italy.

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