963 results match your criteria Acta Dermatovenerologica Croatica[Journal]

Should Paraben Mix Be Removed from The European Baseline Series.

Acta Dermatovenerol Croat 2021 Dec;29(3):171-172

Inês Nunes, MD, Hospital and University Centre of Coimbra, Portugal, Coimbra, Portugal;

Dear Editor: The European Baseline Series (EBS) of contact allergens is used throughout Europe as a screening test to diagnose contact allergy as a proxy for allergy contact dermatitis and other hypersensitivity skin diseases (1). Parabens are alkyl esters of p-hydroxybenzoic acid with antimicrobial effects used as preservatives in cosmetics, foods, and drugs that have been included in the so called "baseline series" (2) for more than 40 years. Parabens, which are considered allergologically safe biocides and are classified as safe by the US Food and Drug Administration (FDA) and the Scientific Committee on Consumer Safety (SCCS) in Europe (2-4), are frequently present in cosmetics (5). Read More

View Article and Full-Text PDF
December 2021

Angiokeratoma Circumscriptum Naeviforme Presenting as a Dark Warty Plaque on the Leg.

Acta Dermatovenerol Croat 2021 Dec;29(3):169-170

Diego Abbenante, MD, Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Bologna, Via Massarenti 1, 40100, Bologna, Italy;

Dear Editor, A 45-year-old man presented with a large, dark, keratotic, warty, and friable plaque on the distal posterior aspect of the left leg (Figure 1, a). The patient reported that the lesion was not present at birth but had appeared approximately at the age of three as an erythematous patch that progressively grew over the time. During adolescence, the surface of the lesion became rough and warty and was easily traumatized due to its location, resulting in recurrent bleeding episodes over a period of years. Read More

View Article and Full-Text PDF
December 2021

A Case of Nevoid Acanthosis Nigricans Successfully Treated with Topical Ketoconazole Plus Urea.

Acta Dermatovenerol Croat 2021 Dec;29(3):167-168

Kozo Nakai, MD, PhD, Department of Dermatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan;

Dear Editor, Nevoid acanthosis nigricans (AN) is a rare form of benign AN that can be mostly found as a solitary lesion distributed along Blaschko's lines (1). It is not associated with any known syndrome, endocrinopathy, drugs, or internal malignancy. Treatments include retinoid, calcipotriol, and laser treatments (2). Read More

View Article and Full-Text PDF
December 2021

A Case Report of an Infant with Autosomal Recessive Dystrophic Epidermolysis Bullosa: COL7A1 Gene Mutations at C2005T and G7922A.

Jing Liu Lin Wang

Acta Dermatovenerol Croat 2021 Dec;29(3):164-166

Jing Liu, MD, Huaibei People's Hospital (The Huaibei Clinical College of Xuzhou Medical University), Huaibei City, China;

A male infant was born by spontaneous delivery on February 7, 2020, with a gestational age of 40 weeks and a birth weight of 4.1 kg. After birth, the infant presented with appearance of skin loss on the bilateral lower limbs, feet, left wrist, face, and lips. Read More

View Article and Full-Text PDF
December 2021

Coxsackie B3 Virus-induced Acute Hemorrhagic Edema of Infancy.

Acta Dermatovenerol Croat 2021 Dec;29(3):159-163

Professor Sonja Radakovic, MD, Department of Dermatology, Medical University of Vienna , Währinger Gürtel 18-20, 1090 Vienna, Austria;

Acute hemorrhagic edema of infancy (AHEI) is a cutaneous leukocytoclastic small vessel vasculitis of unknown incidence. It affects mostly infants aged 4 to 24 months. The distinctive features of AHEI include a generally healthy-appearing child with low-grade or absent fever and rarely painful targetoid purpuric edematous lesions. Read More

View Article and Full-Text PDF
December 2021

A Misdiagnosed Desmoplastic Neurotropic Melanoma of the Scalp: A Challenging Case for the Pathologist and Surgeon.

Acta Dermatovenerol Croat 2021 Dec;29(3):154-158

Paolo Toninello, MD, Plastic and Reconstructive Surgery Unit, Department of Neurosciences, University of Padua, Padua, Italy;

Desmoplastic neurotropic melanoma (DNM) is a rare melanoma subtype that shows tropism for the nerves, perineural invasion correlates to higher rate of local recurrence, poorer prognosis and worse morbidity. Given the paucity of typical melanoma features, both clinical and pathological, this confusing skin cancer may act as a pretender, thus leading clinician to misdiagnosis and subsequent inappropriate conservative treatment. Sarcomatoid-like cells rearrangement and absence of pigmentation can lead towards sarcoma diagnosis, so specific skills are required to pathologist to properly recognize this melanoma subtype. Read More

View Article and Full-Text PDF
December 2021

Maskne: A New Entity in the COVID-19 Pandemic.

Acta Dermatovenerol Croat 2021 Dec;29(3):148-153

Prof. Zrinka Bukvić Mokos, MD, PhD, School of Medicine, University of Zagreb Department of Dermatology and Venereology, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia;

The term "maskne" has been coined during the ongoing COVID-19 pandemic, designating acne associated with prolonged protective mask-wearing. Maskne is a variant of acne mechanica caused by mask-induced mechanical injury (pressure, friction, and rubbing) and occlusion. The additional factors influencing the onset of maskne include genetics, environmental factors, duration of mask-wearing, the type of mask, and previous facial skin disease. Read More

View Article and Full-Text PDF
December 2021

Potential Dermatological Conditions Resulting from a Prolonged Stay at Home during the COVID-19 Pandemic: A Review.

Acta Dermatovenerol Croat 2021 Dec;29(3):135-147

Diana Isabel Conde Hurtado, MD, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia;

A new coronavirus emerged in 2019 in Wuhan, China named Severe Acute Respiratory Syndrome type 2 coronavirus (SARS-CoV-2). Later, this virus spread worldwide, causing a disease called coronavirus disease (COVID-19). To control the outbreak, many countries announced mandatory quarantine; thus, people changed their lifestyles and started engaging in most activities from home. Read More

View Article and Full-Text PDF
December 2021

Modified Mohs Micrographic Surgery in Lentigo Maligna Treatment: A Series of Six Cases.

Acta Dermatovenerol Croat 2021 Dec;29(3):127-134

Alexandra Zota, MD, Dr. Leventer Centre, Bucharest, Romania;

The surgical approach to lentigo maligna is a challenge to dermatologists, given its clinical and histopathological particularities. Staged excision with paraffin-embedded, permanent sections for histopathological evaluation of surgical margins is an effective treatment of lentigo maligna because it enables complete excision of the tumor, at the same time preserving maximum amount of healthy tissue. We report a case series of 6 patients diagnosed with lentigo maligna who underwent this procedure in our Institution and we describe the procedure we used. Read More

View Article and Full-Text PDF
December 2021

Psoriasis and 5HT-R2C Gene Polymorphism: Association between Clinical, Demographic and Therapeutic Parameters in the Turkish Population.

Acta Dermatovenerol Croat 2021 Dec;29(3):121-126

Sehime G. Temel, MD, PhD, Department of Medical Genetics, Bursa Uludag University Faculty of Medicinersa, 16059, Bursa; Turkey;

We aimed to investigate the relationship between single nucleotide polymorphism (SNP) in the promoter region of the 5-HT-R2C gene and stress-related disease psoriasis in the Turkish population. The putative association between the 5-HTR2C variant (rs6318 Cys23Ser allele) and patients with psoriasis was investigated. 100 patients with psoriasis and 100 age-sex matched, unrelated healthy subjects representing the control group were included in the study. Read More

View Article and Full-Text PDF
December 2021

A Case of Possible Concurrence of Dermatitis Herpetiformis and Linear Immunoglobulin A / Immunoglobulin G Bullous Dermatosis.

Acta Dermatovenerol Croat 2021 Jul;29(2):116-117

Satoko Minakawa, MD, PhD, Department of Dermatology Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan;

Dear Editor, Linear immunoglobulin (Ig) A bullous dermatosis (LABD), one subtype of subepidermal autoimmune bullous skin diseases (AIBDs), is characterized by linear deposit of only IgA along the basement membrane zone (BMZ) on direct immunofluorescence (DIF) (1,2). Patients showing linear deposits of both IgA and IgG are diagnosed with linear IgA/IgG bullous dermatosis (LAGBD) (3,4). Dermatitis herpetiformis (DH) is another type of subepidermal AIBD characterized by clinically pruritic erythematous skin lesions with vesicles on the elbows, knees, and buttocks with granular IgA deposits of IgA by DIF (5). Read More

View Article and Full-Text PDF

Indurated Plaques on the Legs: Think Lymphoma.

Acta Dermatovenerol Croat 2021 Jul;29(2):114-115

Professor Maira E. Herz-Ruelas, MD, PhD, Universidad Autónoma de Nuevo León, Dermatology Department, Hospital Universitario "Dr. José Eleuterio González." , Av. Madero and Gonzalitos S/N 64460 Mitras Centro, Monterrey, Nuevo León, México;

Dear Editor, Primary cutaneous diffuse large B-cell lymphoma, leg-type (PCDLBCL-LT) is a rare and aggressive neoplasm. A timely diagnosis may prevent fatal outcomes; physicians should take this entity into consideration when assessing non-specific lesions on the lower limbs. We present a 69-year-old woman with a 1-month history of a firm plaque on her left leg. Read More

View Article and Full-Text PDF

Diagnostic Delays for Non-melanoma Skin Cancers in Renal Transplant Recipients during the COVID-19 Pandemic: What is Hiding Behind the Mask?

Acta Dermatovenerol Croat 2021 Jul;29(2):111-113

Professor Nikolina Bašić-Jukić, MD, PhD, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia;

Dear Editor, The ongoing pandemic of coronavirus disease 2019 (COVID-19) was declared by the World Health Organization on March 11, 2020, and remains a global challenge. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transmitted primarily through respiratory droplets and aerosols. Even though the COVID-19 vaccine has become available since December 2020, the main preventive measures still include social distancing, hand washing, and the use of protective face masks. Read More

View Article and Full-Text PDF

Two Cases of Hidradenitis Suppurativa Treated with Adalimumab at the Department of Dermatology and Venereology, Clinical Hospital Mostar.

Acta Dermatovenerol Croat 2021 Jul;29(2):108-110

Prof. Jasna Zeljko Penavić, MD, PhD, Department of Dermatology and Venereology, Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina;

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presenting with painful nodules, abscesses, sinus tracts, and scarring (1). HS is a defect of the follicular epithelium; some have therefore called for the naming the disease acne inversa instead of hidradenitis suppurativa. The term acne inversa links the pathogenesis to acne and reflects the fact that it is an expression of follicular occlusion in localizations inverse to acne vulgaris (2). Read More

View Article and Full-Text PDF

Symmetrical Skin Lesions on the Gluteal Region in a Patient with Anti-Laminin-332 Mucous Membrane Pemphigoid.

Acta Dermatovenerol Croat 2021 Jul;29(2):105-107

Nobuki Maki; MD, Department of Dermatology Akita National Hospital, 84-40 Idonosawa, Iwakiuchimichikawa, Yurihonjo, Akita 018-1393 Japan;

Mucous membrane pemphigoid (MMP), previously called cicatricial pemphigoid, is a rare subepidermal immunobullous disorder that primarily affects the mucous membranes (1,2). MMP is divided into two major subtypes, anti-BP180-type MMP and anti-laminin-332 (previously called laminin 5 or epiligrin) MMP. Anti-laminin-332 MMP is known to be associated with malignant tumors (3), which may cause overexpression of autoantibodies and induce autoimmunity to laminin-332 (4). Read More

View Article and Full-Text PDF

Flagellate Dermatitis due to Bleomycin Intake.

Acta Dermatovenerol Croat 2021 Jul;29(2):102-104

Prof. Jacek C Szepietowski, MD, PhD, Department of Dermatology, Venereology and Allergology Wroclaw Medical University, Chalubinskiego 1, 50-368 Wroclaw,

Flagellate dermatitis is a rare cutaneous manifestation in which long, striated erythematous lesion appear on the patient's skin. It is most frequently associated with bleomycin treatment or Shiitake mushroom intake, but it may also be attributed to many other possible causes. Herein we present a case of striated, hyperpigmented lesions which occurred after bleomycin intake. Read More

View Article and Full-Text PDF

Prevalence and Dermoscopic Patterns of Acral Melanocytic Nevi in Turkey.

Acta Dermatovenerol Croat 2021 Jul;29(2):94-101

Zeynep Karaca, MD, Kars Harakani State Hospital, Department of Dermatology, Kars-TURKEY;

Although nevi are frequently encountered in the acral region, very limited studies have reported their prevalence in specific populations. We aimed to determine the prevalence of acral nevi, their dermoscopic patterns, and evaluate patient awareness in a Turkish population. We prospectively examined 2644 patients admitted to the outpatient dermatology clinics between October 2016 and October 2017. Read More

View Article and Full-Text PDF

Effectiveness of Systemic Therapies in Patients with Obesity and Psoriasis: A Single-center Retrospective Study.

Acta Dermatovenerol Croat 2021 Jul;29(2):88-93

Claudio Bonifati, MD, Via Elio Chianesi 53, 00153 Rome, Italy;

This retrospective study included 63 patients with obesity (Body Mass Index; BMI ≥ 30) and psoriasis. Our aim was to verify the effectiveness of different systemic therapies administered to the above cohort of subjects over a period of 1 year. Improvements of 75%, 90%. Read More

View Article and Full-Text PDF

Ultrasound Assessment of Regional Lymph Nodes in Melanoma Staging.

Acta Dermatovenerol Croat 2021 Jul;29(2):80-87

Marija Delaš Aždajić, MD, Department of Dermatology and Venereology , Sestre milosrdnice University Hospital Center , Vinogradska cesta 29 , 10 000 Zagreb , Croatia ;

Background: Melanoma can early metastasize to regional lymph nodes. The sentinel lymph node (SLN) is the first lymph node draining directly from the site of primary melanoma, and the pathohistological status of the SLN is the most significant prognostic factor for overall survival prevalence and prognosis in patients with melanoma. Ultrasound is a very useful for the imaging of regional lymph node metastases, combined with Doppler and cytopuncture. Read More

View Article and Full-Text PDF

Mammary Hidradenitis Suppurativa Lesions - A Suggestion for Phenotyping.

Acta Dermatovenerol Croat 2021 Jul;29(2):72-79

Rune Kjærsgaard Andersen, MD, Department of Dermatology University Hospital Zealand, Roskilde, Sygehusvej 10, 4000 Roskilde, Denmark;

Background: Hidradenitis suppurativa (HS) is an under-diagnosed chronic inflammatory skin disease of the pilosebaceous unit of apocrine gland-rich parts of the body. The mammary area is the fourth most HS-affected area and, as typical lesions include non-fluctuating nodules, abscesses, and tunnels/sinus tracts, mammary HS is often mistaken for other mammary "boils", such as sub-areolar and granulomatous non-lactating breast abscesses. Our objective was to present a spectrum of mammary HS lesions, explore a possible classification, and expose mammary HS as a possible differential diagnosis to non-lactational breast abscesses. Read More

View Article and Full-Text PDF

FOXP3 Predicts Response to Treatment in Mycosis Fungoides.

Acta Dermatovenerol Croat 2021 Jul;29(2):67-71

Ilan Goldberg, MD, Department of Dermatology, Sourasky Medical Center, 6 Weizmann St., Tel-Aviv, Israel;

Background: The role of the T-regulatory cells (Tregs) marker forkhead box Protein 3 (FOXP3) in mycoses fungoides (MF) pathogenesis is unclear and the results of previous studies are inconclusive.

Objective: We aimed at ascertaining the possibility that FOXP3 expression may serve to predict MF stage and response to therapy.

Patients And Methods: Immunohistochemistry staining for FOXP3 was performed on 30 skin biopsies from patients with MF, and FOXP3 expression level was quantitatively graded. Read More

View Article and Full-Text PDF

Pyogenic Granuloma of the Proximal Part of a Nail Unit in a Child.

Acta Dermatovenerol Croat 2021 Apr;291(1):62-63

Ružica Jurakić Tončić, MD, PhD, University of Zagreb School of Medicine, Department of Dermatology and Venereology, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia;

Dear Editor, We present a case of proximal pyogenic granuloma in 4-year-old child. The patient presented to our Department due to a fast-growing lesion on the proximal part of the nail unit. The lesion had appeared over several weeks, and it was extremely painful for the child. Read More

View Article and Full-Text PDF

Maculopapular Cutaneous Mastocytosis Successfully Treated with Omalizumab.

Acta Dermatovenerol Croat 2021 Apr;291(1):60-61

Theodora Kanni, MD, PhD, Department of Dermatology and Venereology Andreas Sygros Hospital , 5 Ionos Dragoumi Str, 161 21 Athens, Greece;

Dear Editor, Maculopapular cutaneous mastocytosis (MPCM), formerly telangiectasia macularis eruptiva perstans (TMEP), is an uncommon form of cutaneous mastocytosis first described on 1930 (1). It is more frequent in adults, and early diagnosis is crucial since it has been reported to be associated with serious underlying systemic disorders, such as myeloproliferative diseases and severe manifestations like anaphylaxis (2,3). Treatment of MPCM depends on the presence of systemic involvement and/or the clinical symptoms of the disease itself. Read More

View Article and Full-Text PDF

A Reminder of Skin Cancer During the COVID-19 Pandemic.

Acta Dermatovenerol Croat 2021 Apr;291(1):58

Nika Filipović, MD. University Hospital Centre Sestre Milosrdnice. Vinogradska cesta 29, Zagreb, Croatia;

The year 2020 has been marked by the coronavirus disease 2019 (COVID-19) pandemic, caused by an RNA virus called SARS-COV2 (severe acute respiratory syndrome coronavirus). The fight against this epidemic has become the center of our daily clinical practice as well as of our private lives, in which avoiding infection has become one of our most important goals. Even though COVID-19 is a potentially lethal disease, especially for the elderly and people with chronic diseases, it did not cause all the other life-threatening diseases to vanish. Read More

View Article and Full-Text PDF

Digital Clubbing in Hereditary Hemorrhagic Telangiectasia/Juvenile Polyposis Syndrome.

Acta Dermatovenerol Croat 2021 Apr;291(1):56-57

Anna Mrzljak MD, PhD, Department of Gastroenterology and Hepatology, University Hospital Center Zagreb, Kišpatićeva 12, Zagreb; School of Medicine, University of Zagreb, , Salata 3b, 10000 Zagreb, Croatia;

Hereditary hemorrhagic telangiectasia (HHT) (Osler-Weber-Rendu Syndrome) is a rare autosomal dominant vascular disorder characterized by the presence of multiple arteriovenous malformations (AVMs) and recurrent bleeding episodes. The diagnosis is based on the Curacao criteria: (i) spontaneous recurrent epistaxis, (ii) mucocutaneous telangiectasia, (iii) AVMs of visceral organs, and (iv) first degree relatives with a similar condition (1). Due to a common genetic pathway and SMAD4 gene mutation, juvenile polyposis syndrome (JPS) may coexist with HHT (2). Read More

View Article and Full-Text PDF

Vitiligo-like Depigmentation in a Patient Undergoing Treatment with Nivolumab for Advanced Renal-cell Carcinoma.

Acta Dermatovenerol Croat 2021 Apr;291(1):54-55

Inigo Navarro-Fernandez, MD, Calle Mirador del Candado, , 1 29018 Malaga (Spain),

Dear Editor, Nivolumab is a fully human monoclonal antibody that targets the programmed cell death 1 (PD-1) immune checkpoint. It has been approved for its use in several types of advanced solid tumors, including melanoma, lung cancer, and renal cell carcinoma (RCC). The inhibition of PD-1 leads to an enhanced adaptive immune response against tumor cells through the activation of T-cells. Read More

View Article and Full-Text PDF

Scleromyxedema Without Monoclonal Gammopathy Treated with Intravenous Immunoglobulins.

Acta Dermatovenerol Croat 2021 Apr;291(1):51-53

Mathilde Letzelter, MD, 4 Rue Larrey, 49100 Angers,

Scleromyxedema is a generalized cutaneous mucinosis that may cause internal damage. This condition is frequently associated with monoclonal gammopathy. However, its physiopathological implications remains uncertain. Read More

View Article and Full-Text PDF

The Pancreatitis, Panniculitis, and Polyarthritis (PPP) Syndrome: Subcutaneous Nodular Fat Necrosis, a Cutaneous Marker of Pancreatic Neoplasia.

Acta Dermatovenerol Croat 2021 Apr;291(1):46-50

Małgorzata Bernacka, MD, Department of Dermatology and Venereology, Medical University of Lodz, , Plac J. Hallera 1/6, 90-647 Lodz, Poland;

The pancreatitis, panniculitis, polyarthritis (PPP) syndrome is a rare skin, joint, and pancreatic disorder, also known as subcutaneous nodular fat necrosis. It results from obstruction of pancreatic ducts with direct secretion of pancreatic enzymes into the bloodstream, causing extra pancreatic fat necrosis with subcutaneous tissue and joint inflammation. It is usually a cutaneous sign of pancreatic cancer or pancreatitis. Read More

View Article and Full-Text PDF

Extensive Cutaneous Ulceration of the Scalp - Unknown Disease Entity or Dermatitis Artefacta?

Acta Dermatovenerol Croat 2021 Apr;291(1):42-45

Kornelia Pietrauszka, MD, ul. Francuska 20/24, 40-027 Katowice, Poland;

Psychological disturbances and emotional stress events may elicit a wide spectrum of skin disturbances which are classified as dermatitis artefacta. This diagnosis should be taken into consideration when symptoms coexist in a bizarre pattern or indicate at least several distinct skin pathologies while laboratory tests remain inconclusive. We present a case of dermatitis artefacta which produced very extensive loss of the scalp. Read More

View Article and Full-Text PDF

An Uncommon Presentation of Darier-White Disease with Hystrix-like Palmoplantar Keratoderma.

Acta Dermatovenerol Croat 2021 Apr;291(1):39-41

Ilan Goldberg, MD, Department of Dermatology Tel-Aviv Sourasky Medical Center, 6 Weizmann Street, Tel-Aviv, Israel;

Darier-White disease is a relatively common autosomal dominant genodermatosis caused by mutation in the ATP2A2 gene. It is characterized by multiple warty papules coalescing into plaques in the seborrheic areas and by specific histological skin changes. Palm and sole involvement in Darier-White disease is usually mild, mainly featuring discrete and small keratotic papules. Read More

View Article and Full-Text PDF