652,862 results match your criteria Acta Dermatovenerologica Alpina Panonica et Adriatica [Journal]


Association between different types of plant-based diets and leptin levels in healthy volunteers.

Acta Biochim Pol 2019 Feb 15. Epub 2019 Feb 15.

of Clinical Nutrition and Dietetics, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland.

Leptin is an important factor regulating appetite and energety metabolism; disturbances in its signaling are related to adiposity and contribute to the excessive body fat. About a third of the human population is overweight or suffers from obesity, as well as from associated medical conditions. It is well established that vegetarian, especially vegan, diet is very effective in lowering BMI and body fat, thus, plant-based diets are associated with a lower risk of obesity. Read More

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http://dx.doi.org/10.18388/abp.2018_2725DOI Listing
February 2019

Spectral fingerprinting of decellularized heart valve scaffolds.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 5;214:95-102. Epub 2019 Feb 5.

Institute of Multiphase Processes, Leibniz Universität Hannover, Germany. Electronic address:

Decellularized heart valves hold promise for their use as bioscaffolds in cardiovascular surgery. Quality assessment of heart valves after decellularization processing and/or storage is time consuming and destructive. Fourier transform infrared spectroscopy (FTIR) allows rapid non-invasive assessment of biomolecular structures in tissues. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.006DOI Listing
February 2019

Volume-conserving photoisomerization of a nonplanar GFP chromophore derivative: Nonadiabatic dynamics simulation.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 5;214:86-94. Epub 2019 Feb 5.

School of Physics and Optoelectronic Engineering, Ludong University, Yantai 264025, China. Electronic address:

Nonadiabatic dynamics of a nonplanar green fluorescent protein (GFP) chromophore derivative was examined theoretically by trajectory surface hopping approach at the CASSCF level based on Zhu-Nakamura theory. The geometry optimizations show that there are four ground-state minima and four conical intersections between the ground (S) and first excited (S) states. Four S-state minima were found at a perpendicularly twisted conformation around the imidazolinone-bridged bond. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.001DOI Listing
February 2019

IR, Raman and SERS analysis of amikacin combined with DFT-based calculations.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 6;214:79-85. Epub 2019 Feb 6.

Faculty of Physics, Babeş-Bolyai University, Mihail Kogalniceanu 1, 400084 Cluj-Napoca, Romania; Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babeş-Bolyai University, Treboniu Laurian 42, 400271 Cluj-Napoca, Romania. Electronic address:

Amikacin, a molecule formed by two glucosamine rings linked by α-linkages through a central deoxystreptamine, is an antibiotic often used in clinical treatments, with a special attention in the pediatric cases, due to the physiological activity of their renal system. In spite of its extensive use, no detailed information about the vibrational features of the molecule is available in the literature. Thus, in this study we performed a comprehensive vibrational investigation of amikacin from both an experimental and theoretical point of view. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.012DOI Listing
February 2019

Spectroscopic and quantum chemical study of difluoroboron β-diketonate luminophores: Isomeric acetylnaphtholate chelates.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 6;214:67-78. Epub 2019 Feb 6.

Far Eastern Federal University, School of Natural Sciences, Vladivostok 690950, Russian Federation.

The electronic structure and optical properties of the isomeric difluoroboron β-diketonates, 2,2-difluoro-4-methylnaphtho-[2,1-e]-1,3,2-dioxaborin (I) and 2,2-difluoro-4-methylnaphtho-[1,2-e]-1,3,2-dioxaborin (II), were studied by means of X-ray photoelectron, absorption and luminescence spectroscopies. The experimental results were interpreted using high-level ab initio quantum chemical computations, including the algebraic-diagrammatic construction method for the polarization propagator of the second and third orders (ADC(2) and ADC(3)), the outer-valence Green's function (OVGF) method, and the time-dependent density functional (TDDFT) approach. The X-ray photoelectron measurements were assigned in the entire energy range using the results of the Kohn-Sham orbital calculations which employed the B3LYP functional. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.002DOI Listing
February 2019

Nonlinear optical characterization of porous carbon materials by CARS, SHG and TPEF.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 6;214:58-66. Epub 2019 Feb 6.

Center for Green Innovation, School of Mathematics and Physics, Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface Science, University of Science and Technology Beijing, Beijing 100083, China. Electronic address:

The Coherent anti-Stokes Raman scattering (CARS) microscopy is employed to characterize porous carbon materials. The slices of two dimensional (2D) CARS images are obtained, using Z-scan technology. Furthermore, the three dimensional (3D) image of CARS is reconstructed with the Z-scanned 2D CARS images. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.010DOI Listing
February 2019

Microgels: Modular, Tunable Constructs for Tissue Regeneration.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

Chemical & Biological Engineering, Colorado School of Mines, Golden, CO, United States. Electronic address:

Biopolymer microgels are emerging as a versatile tool for aiding in the regeneration of damaged tissues due to their biocompatible nature, tunable microporous structure, ability to encapsulate bioactive factors, and tailorable properties such as stiffness and composition. These properties of microgels, along with their injectability, have allowed for their utilization in a multitude of different tissue engineering applications. Controlled release of growth factors, antibodies, and other bioactive factors from microgels have demonstrated their capabilities as transporters for essential bioactive molecules necessary for guiding tissue reconstruction. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.011DOI Listing
February 2019

Augmenting the synergies of chemotherapy and immunotherapy through drug delivery.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, Georgia, 30332, United States; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, Georgia, 30332, United States; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Dr NW, Atlanta, Georgia, 30332, United States; Emory University, 201 Dowman Drive, Atlanta, Georgia, 30322, United States; Emory University School of Medicine, 1365-C Clifton Road NE, Winship Cancer Institute, Atlanta, Georgia, 30322, United States. Electronic address:

Despite the recent approvals of multiple cancer immunotherapies, low tumor immunogenicity and immunosuppressive tumor microenvironments prevent a large portion of patients from responding to these treatment modalities. Given the immunomodulatory and adjuvant effects of conventional chemotherapy as well as its widespread clinical use, the use of chemotherapy in combination with immunotherapy (so-called chemoimmunotherapy) is an attractive approach to potentiate the effects of immunotherapy in more patient populations. However, due to the limited extent of tumor accumulation, poorly controlled interactions with the immune system, and effects on systemic healthy tissues by chemotherapeutic drugs, the incorporation of anti-cancer agents into biomaterial-based structures, such as nanocarriers, is highly attractive to improve the safety and efficacy of chemoimmunotherapy. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.012DOI Listing
February 2019

In Vitro Testing of a First-In-Class Tri-alkylnorspermidine-biaryl Antibiotic in an Anti-biofilm Silicone Coating.

Acta Biomater 2019 Feb 12. Epub 2019 Feb 12.

George E. Wahlen Department of Veterans Affairs, Salt Lake City, Utah, United States; Department of Orthopaedics, University of Utah, Salt Lake City, Utah, United States; Curza Global, LLC, Salt Lake City, Utah, United States; Department of Pathology, University of Utah, Salt Lake City, Utah, United States; Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States; Department of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address:

Biofilm-related infection is among the worst complication to prosthetic joint replacement procedures; once established on the implant surface, biofilms show strong recalcitrance to clinical antibiotic therapy, frequently requiring costly revision procedures and prolonged systemic antibiotics for their removal. A well-designed active release coating might assist host immunity in clearing bacterial contaminants within the narrow perioperative window and ultimately prevent microbial colonization of the joint prosthesis. A first-in-class compound (CZ-01127) was tested as the active release agent in a silicone (Si) coating using an in vitro dynamic flow model of surgical site contamination and compared with analogous coatings containing clinical gold-standard antibiotics vancomycin and gentamicin; the CZ-01127 coating outperformed both vancomycin and gentamicin coatings and was the only to decrease the methicillin-resistant Staphylococcus aureus (MRSA) inocula below detectable limits for the first 3 days. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.010DOI Listing
February 2019

CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: Novel microglial models for X-linked Adrenoleukodystrophy.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Feb 12. Epub 2019 Feb 12.

Laboratoire Bio-PeroxIL EA7270, University of Bourgogne Franche-Comté, Dijon, France. Electronic address:

X-linked adrenoleukodystrophy (X-ALD), the most frequent peroxisomal disorder, is associated with mutation in the ABCD1 gene which encodes a peroxisomal ATP-binding cassette transporter for very long-chain fatty acids (VLCFA). The biochemical hallmark of the disease is the accumulation of VLCFA. Peroxisomal defect in microglia being now considered a priming event in the pathology, we have therefore generated murine microglial cells mutated in the Abcd1 gene and its closest homolog, the Abcd2 gene. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.02.006DOI Listing
February 2019

Novel functions of phospholipase As: Overview.

Authors:
Makoto Murakami

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; AMED-CREST, Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.02.005DOI Listing
February 2019

PKA negatively modulates the migration enhancing effect of Connexin 43.

Biochim Biophys Acta Mol Cell Res 2019 Feb 12. Epub 2019 Feb 12.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München and Munich University Hospital, Großhaderner Str. 9, 82152 Planegg, Martinsried, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Biedersteiner Str. 29, 80802 München, Germany. Electronic address:

Connexin 43 (Cx43) expression is associated with an increased cell migration and related changes of the actin cytoskeleton (enhanced filopodia formation). These effects are mediated by the C-terminal cytoplasmic part of Cx43 in a channel-independent manner. Since this part has been shown to interact with a variety of proteins and has multiple phosphorylation sites we analyzed here a potential role of the protein kinase A (PKA) for the Cx43 mediated increase in cell migration. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.02.001DOI Listing
February 2019

Morphological Study of the urotergite I process in Ten Species of the Genus Triatoma (Hemiptera, Reduviidae, Triatominae).

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Entomology in Public Health, Department of Epidemiology, School of Public Health, University of São Paulo, Av. Dr. Arnaldo, 715, Pinheiros, São Paulo, São Paulo, CEP 01246-904, Brazil.

The insects of subfamily Triatominae exhibit many morphological features used for taxonomic identification. In some species, however, these features are very similar. The authors have proposed by first time the description of the structure referred as urotergite I process. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.012DOI Listing
February 2019

Diagnostic performance of CellaVision DM96 for Plasmodium vivax and Plasmodium falciparum screening in peripheral blood smears.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Department of Laboratory Medicine, Korea University College of Medicine, Seoul, South Korea. Electronic address:

Microscopic examination of blood smears is the standard method for malaria diagnosis but is labor-intensive and requires expert staff. CellaVision DM96 (CellaVision, Lund, Sweden) is a digital hematology analyzer available for advanced morphological analysis of blood films including intracellular parasites. Here, we evaluated the CellaVision DM96 Advanced RBC Application for malaria detection in stained peripheral blood (PB) smears. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183084
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http://dx.doi.org/10.1016/j.actatropica.2019.02.009DOI Listing
February 2019
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FLEAS ASSOCIATED WITH SIGMODONTINE RODENTS AND MARSUPIALS FROM THE PARANAENSE FOREST IN NORTHEASTERN ARGENTINA.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Centro de Estudios Parasitológicos y de Vectores (CEPAVE) (CONICET CCT La Plata-UNLP), Boulevard 120 s/n e/60 y 64, 1900, La Plata, Argentina. Electronic address:

Fleas from the Paranaense Forest in northeastern Argentina are studied. Herein we provided a list of specimens identified, which includes host species and geographical distribution for each taxa, as well as some comments on the morphology, distribution and epidemiological importance when available. The following eight species and subspecies of fleas belonging to four families were identified: Ctenocephalides felis felis (Pulicidae), Craneopsylla minerva minerva (Stephanocircidae), Polygenis (Polygenis) platensis, Polygenis (Polygenis) roberti beebei, Polygenis (Neopolygenis) pradoi, Polygenis (Neopolygenis) pygaerus (Rhopalopsyllidae), Adoratopsylla (Adoratopsylla) antiquorum antiquorum, and Adoratopsylla (Tritopsylla) intermedia intermedia (Ctenophthalmidae). Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.011DOI Listing
February 2019

Parasites of Gymnodactylus darwinii Gray, 1845 (Squamata, Phyllodactylidae) from an Atlantic Rainforest fragment.

Acta Trop 2019 Feb 12. Epub 2019 Feb 12.

Programa de Pós-Graduação em Ecologia, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Programa de Pós-Graduação em Ciência Animal Tropical, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil; Laboratório de Parasitologia (LAPAR), Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, CEP 52171-900, Recife, Pernambuco, Brazil. Electronic address:

Gymnodactylus darwinii is an endemic lizard from Atlantic Rainforest. Ecological aspects of your parasitic fauna are still unknown. Therefore, the goal of the present study was to know the composition of parasitic fauna of G. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.010DOI Listing
February 2019

Involvement of Caveolin-1 and CD36 in native LDL endocytosis by endothelial cells.

Biochim Biophys Acta Gen Subj 2019 Feb 12. Epub 2019 Feb 12.

Institute of Chemistry and Biology of Membranes and Nano-objects (CBMN), UMR 5248, CNRS, University of Bordeaux, INP, F-33600 Pessac, France.

Atherosclerosis is a lipid disease characterized by accumulation of low density lipoprotein (LDL) in the artery wall. The transport of LDL across the endothelium of coronary artery is an initiating event of atherosclerosis, whose mechanism remains poorly understood. In the last decade, it has been shown that in caveolin-1 (Cav-1) deficient mice, LDL infiltration in aorta wall is decreased and CD36 expression in aortas is down-regulated, leading to regression of atherosclerotic lesions. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.01.005DOI Listing
February 2019

A multidimensional concept for mercury neuronal and sensory toxicity in fish - from toxicokinetics and biochemistry to morphometry and behavior.

Biochim Biophys Acta Gen Subj 2019 Feb 12. Epub 2019 Feb 12.

Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address:

Background: Neuronal and sensory toxicity of mercury (Hg) compounds has been largely investigated in humans/mammals with a focus on public health, while research in fish is less prolific and dispersed by different species. Well-established premises for mammals have been governing fish research, but some contradictory findings suggest that knowledge translation between these animal groups needs prudence [e.g. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.01.020DOI Listing
February 2019

Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease.

Clin Chim Acta 2019 Feb 12. Epub 2019 Feb 12.

Clinic of Cardiology and Emergency Internal Medicine, Military Medical Academy, Belgrade, Serbia; Institute for Medical Statistics and Informatics, School of Medicine, University of Belgrade, Serbia; School of Medicine, University of Defense, Belgrade, Serbia. Electronic address:

Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.008DOI Listing
February 2019

Periplasmic expression of a restriction endonuclease in Escherichia coli and its effect on the antiviral activity of the host.

Acta Biochim Pol 2019 Feb 15. Epub 2019 Feb 15.

University of Gdansk, Department of Microbiology, Wita Stwosza 59, 80-308 Gdańsk, Poland.

One possible mechanism preventing phage infection of the bacterial cells is related to the presence of an effective restriction-modification system (R-M) which allows restriction of the invading DNA. However, there are some limitations to the absolute restriction of foreign DNA. Since there is a serious conflict between increase in the restriction-modification genes expression level and cell viability, we examined the antiviral effect of EcoRI restriction endonuclease after its translocation to the periplasmic space of the cell. Read More

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http://dx.doi.org/10.18388/abp.2018_2740DOI Listing
February 2019

A walk through tau therapeutic strategies.

Acta Neuropathol Commun 2019 Feb 15;7(1):22. Epub 2019 Feb 15.

AXON Neuroscience R&D Services SE, Dvorakovo nabrezie 10, 811 02, Bratislava, Slovakia.

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel from cell to cell and spread the pathology through the brain. Throughout the last decade, physiological and pathological tau have become attractive targets for AD therapies. Read More

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http://dx.doi.org/10.1186/s40478-019-0664-zDOI Listing
February 2019

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments.

Acta Neuropathol Commun 2019 Feb 15;7(1):21. Epub 2019 Feb 15.

Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

PP2A is a major regulator of tau phosphorylation, which is principally regulated by an endogenous nuclear protein inhibitor 2 of PP2A (I), also named SET. However, how SET is post-translationally regulated and translocates from the nucleus to the cytoplasm remain incompletely understood. Here we show SET is SUMOylated at K68 residue that induces its cytoplasmic retention, resulting in Alzheimer disease (AD) like tau pathology and cognitive defects. Read More

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http://dx.doi.org/10.1186/s40478-019-0663-0DOI Listing
February 2019

Rituximab prescription patterns and efficacy in the induction treatment of ANCA-Associated Vasculitis in a Belgian multicenter cohort.

Acta Clin Belg 2019 Feb 15:1-7. Epub 2019 Feb 15.

a Internal Medicine, Erasme Hospital , Université Libre de Bruxelles , Anderlecht , Belgium.

Introduction: The RAVE trial has revolutionized induction treatment of anti-neutrophil cytoplasmic antibodies (ANCA)-Associated Vasculitis (AAV)by demonstrating the non-inferiority of rituximab (RTX) compared with cyclophosphamide.

Objectives: We studied AAV patients' characteristics, RTX prescription practices and efficacy in AAV induction treatment in four Belgian university hospitals. The patient population, selected according to the Belgian reimbursement criteria, was relatively homogeneous and comparable to the one of RAVE trial. Read More

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http://dx.doi.org/10.1080/17843286.2019.1578041DOI Listing
February 2019

A plethora of manifestations following a Mycoplasma pneumoniae infection: a case report.

Acta Clin Belg 2019 Feb 15:1-6. Epub 2019 Feb 15.

e Department of Gastroenteroly , AZ Maria Middelares , Ghent , Belgium.

Mycoplasma pneumoniae infection can present with a plethora of symptoms and result in a systemic vasculitis by activating a cascade of autoimmune reactions. In this case report, a young man without relevant past medical history was admitted to the hospital with diarrhea, abdominal pain and spiking fever. A CT-scan showed terminal ileitis. Read More

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http://dx.doi.org/10.1080/17843286.2019.1578029DOI Listing
February 2019

Diagnostic value of eye movement and vestibular function tests in patients with posterior circulation infarction.

Acta Otolaryngol 2019 Feb 15:1-11. Epub 2019 Feb 15.

a Peking University Aerospace School of Clinical Medicine , Beijing , P.R. China.

Objective: To evaluate the diagnostic value of eye movements and vestibular function tests in PCI patients.

Methods: Thirty-eight PCI patients and 31 patients with unilateral vestibular neuritis (UVN) were enrolled and underwent eye movement tests and vestibular function tests (spontaneous nystagmus [SN], head-shaking nystagmus [HSN]).

Results: The rates of eye movement abnormality were 78. Read More

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http://dx.doi.org/10.1080/00016489.2018.1552367DOI Listing
February 2019

Cost-effectiveness of pulp capping and root canal treatment of young permanent teeth.

Acta Odontol Scand 2019 Feb 15:1-7. Epub 2019 Feb 15.

a Department of Endodontics, Faculty of Odontology , Malmö University , Malmö , Sweden.

Objective: To contribute with information on cost-effectiveness of pulp capping and root canal treatment of posterior permanent vital teeth in children and adolescents with pulp exposures due to caries.

Material And Methods: Cost-effectiveness by means of a Markov simulation model was studied in a Scandinavian setting. In a simulated 12-year-old patient, treatment of pulpal exposure of a permanent tooth, either by the initial treatment pulp capping or root canal treatment, was followed for 9 years until the patient was 21. Read More

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http://dx.doi.org/10.1080/00016357.2018.1538536DOI Listing
February 2019

The utility of a new fundus camera using a portable slit lamp combined with a smartphone.

Acta Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/aos.14049DOI Listing
February 2019

Placental location and pregnancy outcomes in nulliparous women: A population-based cohort study.

Acta Obstet Gynecol Scand 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.

Introduction: The impact of placenta previa on pregnancy, delivery and infant outcomes has been extensively studied. Less is however known about the possible association of placental location other than previa with pregnancy outcomes. The aim of this study was to investigate if placental location other than previa is associated with adverse pregnancy, delivery and infant outcomes. Read More

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http://dx.doi.org/10.1111/aogs.13578DOI Listing
February 2019

Progress in rapid optical assays for heavy metal ions based on the use of nanoparticles and receptor molecules.

Mikrochim Acta 2019 Feb 14;186(3):172. Epub 2019 Feb 14.

A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky prospect 33, Moscow, 119071, Russia.

This review (with 230 refs.) covers recent progress in rapid optical assays for heavy metals (primarily lead and mercury as the most relevant) based on the use of nanoparticles and receptor molecules. An introduction surveys the importance, regulatory demands (such as maximum permissible concentrations) and potential and limitations of various existing methods. Read More

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http://dx.doi.org/10.1007/s00604-018-3168-9DOI Listing
February 2019

Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension.

Acta Pharm Sin B 2019 Jan 7;9(1):194-201. Epub 2018 Jul 7.

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.

This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol (CAR), cinnarizine (CIN) or R3040 on drug solubilization in a two-compartment lipolysis model. Correlation of drug log or solubility in SNEDDS with drug solubilization during lipolysis in the presence of drug-free SNEDDS was assessed. SNEDDS with varying ratios of soybean oil:Maisine 35-1 (1:1, /) and Kolliphor RH40, with ethanol at 10% (/) were used. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361727PMC
January 2019

Interaction between human serum albumin and cholesterol-grafted polyglutamate as the potential carriers of protein drugs.

Acta Pharm Sin B 2019 Jan 7;9(1):186-193. Epub 2018 Aug 7.

Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.

Currently there is no successful platform technology for the sustained release of protein drugs. It seems inevitable to specifically develop new materials for such purpose, and hence the understanding of protein-material interactions is highly desirable. In this study, we synthesized cholesterol-grafted polyglutamate (PGA--Chol) as a hydrophobically-modified polypeptide, and thoroughly characterized its interaction with a model protein (human serum albumin) in the aqueous solution by using circular dichroism, fluorescence methods, and light scattering. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361731PMC
January 2019

Deep learning for prediction of pharmaceutical formulations.

Acta Pharm Sin B 2019 Jan 28;9(1):177-185. Epub 2018 Sep 28.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, China.

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error methods of pharmaceutical scientists. This approach is laborious, time-consuming and costly. Recently, deep learning has been widely applied in many challenging domains because of its important capability of automatic feature extraction. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362259PMC
January 2019

Efficient lung cancer-targeted drug delivery a nanoparticle/MSC system.

Acta Pharm Sin B 2019 Jan 3;9(1):167-176. Epub 2018 Sep 3.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.

Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped in the lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as lung cancer-targeted drug delivery vehicles by loading nanoparticles (NP) with anti-cancer drug. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362298PMC
January 2019

Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.

Acta Pharm Sin B 2019 Jan 12;9(1):157-166. Epub 2018 Sep 12.

Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China.

Pharmacometabolomics has been already successfully used in toxicity prediction for one specific adverse effect. However in clinical practice, two or more different toxicities are always accompanied with each other, which puts forward new challenges for pharmacometabolomics. Gastrointestinal toxicity and myelosuppression are two major adverse effects induced by Irinotecan (CPT-11), and often show large individual differences. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362258PMC
January 2019

Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms.

Acta Pharm Sin B 2019 Jan 20;9(1):144-156. Epub 2018 Aug 20.

School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361730PMC
January 2019

Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway.

Acta Pharm Sin B 2019 Jan 17;9(1):135-143. Epub 2018 Oct 17.

Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.

Obesity is a worldwide epidemic. Promoting browning of white adipose tissue (WAT) contributes to increased energy expenditure and hence counteracts obesity. Here we show that cordycepin (Cpn), a natural derivative of adenosine, increases energy expenditure, inhibits weight gain, improves metabolic profile and glucose tolerance, decreases WAT mass and adipocyte size, and enhances cold tolerance in normal and high-fat diet-fed mice. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361849PMC
January 2019

Preparation and characterization of multimodal hybrid organic and inorganic nanocrystals of camptothecin and gold.

Acta Pharm Sin B 2019 Jan 22;9(1):128-134. Epub 2018 Mar 22.

Department Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.

We demonstrate a novel inorganic-organic crystalline nanoconstruct, where gold atoms were imbedded in the crystal lattices as defects of camptothecin nanocrystals, suggesting its potential use as simultaneous agents for cancer therapy and bioimaging. The incorporation of gold, a potential computed tomography (CT) contrast agent, in the nanocrystals of camptothecin was detected by transmission electron microscope (TEM) and further quantified by energy dispersive X-ray spectrometry (EDS) and inductively coupled plasma-optical emission spectrometers (ICP-OES). Due to gold's high attenuation coefficient, only a relatively small amount needs to be present in order to create a good noise-to-contrast ratio in CT imaging. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361724PMC
January 2019

Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation.

Acta Pharm Sin B 2019 Jan 19;9(1):118-127. Epub 2018 Jun 19.

Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China.

There has been increasing interest in research and development of nanocrystals for the delivery of poorly water-soluble drugs that can be directly produced from solution. Compared with traditional carrier-based or encapsulation designs, drug nanocrystals circumvent possible side-effects due to carrier polymers and poor stability issues associated with encapsulation. The production of carrier-free nanocrystals requires careful control of nucleation and thus a thorough understanding of the relevant solution's metastable zone. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361733PMC
January 2019

Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus-PVPVA complex.

Acta Pharm Sin B 2019 Jan 10;9(1):107-117. Epub 2018 Sep 10.

Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.

Increasing the degree of supersaturation of drugs and maintaining their proper stability are very important in improving the oral bioavailability of poorly soluble drugs by a supersaturated drug delivery system (SDDS). In this study, we reported a complex system of Soluplus-Copovidone (Soluplus-PVPVA) loaded with the model drug silybin (SLB) that could not only maintain the stability of a supersaturated solution but also effectively promote oral absorption. The antiprecipitation effect of the polymers on SLB was observed using the solvent-shift method. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361729PMC
January 2019

Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan.

Acta Pharm Sin B 2019 Jan 7;9(1):97-106. Epub 2018 Sep 7.

Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.

Tremendous efforts have been devoted to the enhancement of drug solubility using nanotechnologies, but few of them are capable to produce drug particles with sizes less than a few nanometers. This challenge has been addressed here by using biocompatible versatile -cyclodextrin (-CD) metal-organic framework (CD-MOF) large molecular cages in which azilsartan (AZL) was successfully confined producing clusters in the nanometer range. This strategy allowed to improve the bioavailability of AZL in Sprague-Dawley rats by 9. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361728PMC
January 2019

Intestinal uptake of barley protein-based nanoparticles for -carotene delivery.

Acta Pharm Sin B 2019 Jan 12;9(1):87-96. Epub 2018 Oct 12.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Alberta T6G 2P5, Canada.

Our previous study introduced a barley protein microparticle for encapsulation of hydrophobic drug/nutraceutical, which could release nanoparticles upon gastric digestion and deliver encapsulated compound to a simulated intestinal environment intact. This work focused on evaluating the potential of liberated nanoparticles to improve the absorption of encapsulated compounds (., -carotene) using Caco-2 cell and small intestine models. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362262PMC
January 2019

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect.

Acta Pharm Sin B 2019 Jan 20;9(1):74-86. Epub 2018 Sep 20.

Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China.

Diabetes mellitus (DM) remains a great challenge in treatment due to pathological complexity. It has been proven that phytomedicines and natural medicines have prominent antidiabetic effects. This work aimed to develop selenium-layered nanoparticles (SeNPs) for oral delivery of mulberry leaf and extracts (MPE), a group of phytomedicines with significant hypoglycemic activities, to achieve a synergic antidiabetic effect. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361850PMC
January 2019

The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals.

Acta Pharm Sin B 2019 Jan 19;9(1):59-73. Epub 2018 Sep 19.

Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kinetic solubility, thermodynamic solubility, and intrinsic dissolution rate (IDR). The effects of pH, surfactant, ion concentration, and coformers on the cocrystal solubility were evaluated. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361854PMC
January 2019

Emerging transporter-targeted nanoparticulate drug delivery systems.

Acta Pharm Sin B 2019 Jan 24;9(1):49-58. Epub 2018 Oct 24.

Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.

Transporter-targeted nanoparticulate drug delivery systems (nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments in nanotherapeutics. In this review, we outline the recent advances in transporter-targeted nano-DDS. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361857PMC
January 2019

Adapting liposomes for oral drug delivery.

Acta Pharm Sin B 2019 Jan 20;9(1):36-48. Epub 2018 Jun 20.

Key Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China.

Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113835173073
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http://dx.doi.org/10.1016/j.apsb.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362257PMC
January 2019
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Advances in coamorphous drug delivery systems.

Acta Pharm Sin B 2019 Jan 16;9(1):19-35. Epub 2018 Aug 16.

State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

In recent years, the coamorphous drug delivery system has been established as a promising formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a single-phase system containing an active pharmaceutical ingredient (API) and other low molecular weight molecules that might be pharmacologically relevant APIs or excipients. These formulations exhibit considerable advantages over neat crystalline or amorphous material, including improved physical stability, dissolution profiles, and potentially enhanced therapeutic efficacy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113835183062
Publisher Site
http://dx.doi.org/10.1016/j.apsb.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361732PMC
January 2019
1 Read

Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles.

Acta Pharm Sin B 2019 Jan 14;9(1):4-18. Epub 2018 Nov 14.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, Macau, China.

Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation (FNP) has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles, polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. Read More

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http://dx.doi.org/10.1016/j.apsb.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361851PMC
January 2019

Editorial: Persistent endeavors for the enhancement of dissolution and oral bioavailability.

Acta Pharm Sin B 2019 Jan 29;9(1):2-3. Epub 2019 Jan 29.

Key Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China.

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http://dx.doi.org/10.1016/j.apsb.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361848PMC
January 2019

PRECLINICAL STUDENTS' VIEWS ON MEDICAL ETHICS EDUCATION: A FOCUS GROUP STUDY IN TURKEY.

Acta Bioeth 2018 Jun;24(1):105-115

Dokuz Eylul University, Faculty of Medicine, Department of History of Medicine and Ethics, Izmir, Turkey.

Aim: We aimed to receive the opinions of the preclinical medical students on medical ethics education, and to present some suggestions for the education program.

Methods: Focus group discussions were held with third-grade medical students. The analyses were implemented using Creswell's six-step qualitative data analysis. Read More

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